@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0327: (2015-11-30 )
MKVVKFGGSSLASSQQLYKVLNIIKSDYTRRFVVVSAPGKRYEEDLKMTDALIQYYQNYINGKDIVKDQTWIINRYQEIISDLSLGSTIAEEITRSIEQLASLPIENNQFLYDCFLAAGEDNNAKLVATFFNQNDIPARYVHPNEAGIIVTKEPCNARIIPGSYDKIENLCLYNEVLVIPGFFGVTEDNQICTFSRGGSDITGSLIAAGIKADLYENFTDVDGIFAAHPGVVKNPHAIPELTYKEMRELAYAGFSVLHDEALLPAYRDRIPLVIKNTNNPQQPGTKIVLKHTRSNIAVTGIASDSRFASINVSKYLMNREVGFGRKVLQILEDLNISFEHMPTGIDDLSIVLREKELTPIKEQEILNYLTRKLEVDYVDIQHNLSTIVIVGENMKSQIGVTATATQALSREKINITMISQGSSEVSIMFVINSKDEKRAIKALYETFFQK
Atome Classification :
(20 SA)
---.........10........20.....-..---.30---....-....40........50....---....60........---70........80......--------.-.90...----.----....100....----.------....110----.........120.......130.......140.......150-.....-..160.-.-----..----...170-----...------.-----...180....-.-.-..190........200.......210.......220.......230.......240.......250.......260.......270.......280.......-290..-------....------..-----.300.......310.......320--.......330-........-------340--..-------.--.-----.--...350------..-----------.....--360--.--....-...----370--....-.....380.--......390.......400.......410.......420.......430.......440.......450-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
K
V
V
KFGGSSL
A
S
S
Q
Q
L
Y
K
V
L
N
I
I
K
S-DY---T
R
R
---
F
V
V
V
-SAPG
K
R
Y
E
E
D
L
K
M
T
D
A
L
I
Q
Y
---
Y
Q
N
YINGKDIVKD
Q
---
T
W
I
I
N
R
Y
Q
E
I
I
S
DLSL
G
S
--------
T
-
I
A
E
E
I
T
----
R
----
S
I
E
Q
L
--
A
SLP----I------ENN
Q
F
------
L
Y
D
C
F
LAAGEDNN
A
K
L
V
A
T
FFNQNDIP
A
R
Y
VHPNE
A
G
I
I
V
TK-EPCN
A
-
R
IIPG
S
-
Y
-----
D
K
----
I
E
N
L
C
L
-----
Y
N
E
------
V
-----
L
V
IP-GFFGV-T-E-DN
Q
-
I
C
T
FSRGGSD
I
T
G
S
L
I
A
A
G
I
K
A
D
L
Y
ENFTDV
D
G
I
FAAHPGVVKNPHAIP
E
L
T
Y
K
E
M
R
E
L
A
Y
A
G
F
S
V
LHDEALL
P
A
Y
RDRI
P
L
V
I
KNTNNPQQPG
T
K
I
V
L
-
K
--HT-------RS
N
I
------
A
V
-----
T
G
IASDS
R
F
A
S
I
N
V
S
K
Y
L
M
NREVG--
F
G
R
K
V
L
Q
I
L
--
E
DLN
I
S
F
E-------HM---PT-------G--I-----
D
--
D
L
S
I
V
L------RE-----------KELTP--I
K
---
E
--
Q
E
I
L
-
N
Y
L
----
T
----
R
K
L
E
-
V
D
Y
V
D
IQHN--
L
S
T
I
V
I
VGEN
M
K
S
QIG
V
T
A
T
A
T
Q
ALSRE
K
I
N
I
T
M
ISQGSS
E
V
S
I
M
F
V
INSK
D
E
K
R
A
I
K
A
L
Y
E
T
FFQK---------
21
HHSearch
91.78
40%
-103
- C1 -
3TVI
3
?
A:
[4-438]
---
I
V
V
T
K
F
G
G
S
S
L
A
D
S
N
Q
F
K
K
V
K
G
I
I
D
S
-
D
A
---
N
R
K
---
Y
I
I
P
-
S
A
P
G
K
R
T
N
K
D
Y
K
I
T
D
L
L
Y
L
C
---
N
A
H
V
K
N
G
I
P
F
D
D
V
F
---
K
L
I
S
Q
R
Y
T
E
I
V
S
E
L
N
I
D
M
--------
D
-
I
A
Y
Y
L
E
----
K
----
V
K
K
N
I
------------------
E
N
G
A
------
S
S
D
Y
A
A
S
R
G
E
Y
L
N
G
V
I
L
A
K
Y
L
N
A
E
F
I
D
A
-----
A
E
V
I
F
F
D
K
---
C
----
F
D
E
K
K
S
-
Y
-----
E
K
----
I
K
E
K
V
L
-----
S
C
N
------
K
-----
A
V
I
P
-
G
F
Y
G
S
-
S
-
F
-
N
G
D
-
V
K
T
F
S
R
G
G
S
D
V
T
G
S
I
I
S
A
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V
N
A
D
L
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W
T
D
V
S
G
F
L
M
A
D
P
R
I
V
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P
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T
I
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K
I
S
Y
K
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L
R
E
L
S
Y
M
----
L
H
E
E
A
I
F
P
V
K
D
S
G
I
P
I
N
I
K
N
T
N
K
P
S
D
P
G
T
L
I
L
S
D
T
--
H
K
E
------
I
N
L
G
------
T
I
-----
T
G
I
A
G
K
K
N
F
T
V
I
A
I
E
K
A
L
L
N
S
E
V
G
--
F
C
R
K
I
L
S
I
L
--
E
M
Y
G
V
S
F
E
-------
H
M
---
P
S
-------
G
--
V
-----
D
--
S
V
S
L
V
I
------
E
D
-----------
C
K
L
D
G
--
K
C
---
D
---
K
I
I
-
E
E
I
----
K
----
K
Q
C
N
-
P
D
S
I
E
I
H
P
N
--
M
A
L
V
A
T
V
G
T
G
M
A
K
T
K
G
I
A
N
K
I
F
T
A
L
S
K
E
N
V
N
I
R
M
I
D
Q
G
S
S
E
I
N
V
I
V
G
V
E
T
V
D
F
E
K
A
V
K
S
I
Y
N
A
F
N
-----------
1
PsiBlast_PDB
82.51
28%
-94
- C1 -
2CDQ
5
AK1_ARATH
A:
[30-484]
-----
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
F
P
E
---
E
S
P
---
V
I
V
L
-
S
A
M
G
K
T
T
N
N
L
L
L
A
G
E
K
A
V
S
C
GVS
N
A
S
E
I
E
E
L
S
I
I
K
E
L
---
H
--
I
R
T
V
K
E
L
N
I
D
P
S
V
I
L
--------
T
-
Y
L
E
E
L
E
----
Q
----
L
L
K
G
I
--
A
M
M
K
-----------
E
L
T
L
R
------
T
R
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
-
D
F
T
N
G
-
D
I
L
E
A
T
-
Y
-----
P
A
----
V
A
K
R
-
L
-----
Y
D
D
W
M
H
DP
A
V
-----
P
I
V
T
-
G
F
L
G
K
G
W
-
K
-
T
G
A
-
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
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I
Q
V
W
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D
V
D
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V
L
T
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
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A
A
E
L
A
Y
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
N
S
Y
N
P
K
A
P
G
T
I
I
T
K
-
T
--
R
D
-------
M
T
K
S
------
I
L
-----
T
S
I
V
L
K
R
N
V
T
M
L
D
I
A
S
T
R
M
L
G
Q
V
G
--
F
L
A
K
V
F
S
I
F
--
E
E
L
G
I
S
V
D
-------
V
V
---
A
T
-------
S
--
E
-----
V
--
S
I
S
L
T
L
------
D
P
-----------
S
K
L
W
S
RE
L
I
---
Q
--
Q
E
-
L
-
D
H
V
----
V
----
E
E
L
E
K
I
A
V
V
N
L
L
K
G
--
R
A
I
I
S
L
I
G
N
V
Q
H
S
S
L
-
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
M
I
S
Q
G
A
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
---------
3
PsiBlast_PDB
79.58
28%
-90
- C1 -
3C1N
2
AK_METJA
C:
[4-469]
-----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
--------
T
K
R
---
K
K
E
D
-
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
---
S
Q
Q
A
L
D
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
--------
E
-
I
K
E
E
V
K
----
K
I
I
D
S
R
I
E
E
L
--
E
K
V
L
----
I
G
V
A
Y
L
G
E
L
T
P
K
------
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
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I
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T
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G
V
Y
T
T
D
P
R
L
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P
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A
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R
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P
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L
S
Y
I
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A
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A
Y
F
G
A
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V
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H
P
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T
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A
M
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K
G
I
P
I
L
V
K
N
T
F
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P
E
S
E
G
T
L
I
T
N
-
D
--
M
-----------
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
-------
S
Q
---
G
S
-------
S
--
E
-----
T
--
N
I
S
L
V
V
------
S
E
ED
V
D
K
A
L
K
A
L
K
R
E
F
---------------
L
N
N
N
L
----
I
----
R
D
V
S
-
V
D
-----
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
----------
24
HHSearch
78.63
27%
-93
* C1 *
3C1M
6
AK_METJA
A:
[2-470]
---
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
-
R
K
K
E
D
D
D
V
---
V
V
V
V
-
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
V
-------
R
D
I
A
K
V
G
D
F
I
---
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
-
I
D
S
R
I
E
----
E
----
L
E
K
V
L
I
G
V
A
Y
L
----
G
------
E
L
T
P
K
------
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
-
R
V
K
R
L
E
V
K
-----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
--
E
M
--------
S
D
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
--
G
E
E
E
V
N
V
I
-------
L
I
---
S
Q
-------
G
S
S
E
-----
T
--
N
I
S
L
V
V
------
S
E
-----------
E
D
V
D
K
--
A
L
---
K
---
A
L
K
-
R
E
F
----
G
DSFL
N
N
N
L
-
I
R
D
V
S
V
D
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
---------
5
PsiBlast_PDB
78.10
28%
-87
- C1 -
3C1M
6
AK_METJA
A:
[4-470]
-----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
--------
T
K
R
---
K
K
E
D
-
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
---
S
Q
Q
A
L
D
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
--------
E
-
I
K
E
E
V
K
----
K
I
I
D
S
R
I
E
E
L
--
E
K
V
L
----
I
G
V
A
Y
L
G
E
L
T
P
K
------
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
-
D
--
M
E
-------
M
S
D
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
-------
S
Q
---
G
S
-------
S
--
E
-----
T
--
N
I
S
L
V
V
------
S
E
ED
V
D
K
A
L
K
A
L
K
R
E
F
G
D
-----------
S
F
L
N
N
N
L
----
I
----
R
D
V
S
-
V
D
-----
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
---------
2
PsiBlast_PDB
77.79
28%
-87
- C1 -
2HMF
3
AK_METJA
A:
[3-469]
-----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
--------
T
K
R
---
K
K
E
D
-
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
---
S
Q
Q
A
L
D
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
--------
E
-
I
K
E
E
V
K
----
K
I
I
D
S
R
I
E
E
L
--
E
K
V
L
----
I
G
V
A
Y
L
G
E
L
T
P
K
------
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
-
D
--
M
E
-------
M
S
D
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
-------
S
Q
---
G
S
-------
S
--
E
-----
T
--
N
I
S
L
V
V
------
S
E
ED
V
D
K
A
L
K
A
L
K
R
E
F
G
D
--
F
----------
L
N
N
N
L
----
I
----
R
D
V
S
-
V
D
-----
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
---------
4
PsiBlast_PDB
77.69
28%
-87
- C1 -
3C20
3
AK_METJA
A:
[4-470]
-----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
--------
T
K
R
---
K
K
E
D
-
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
---
S
Q
Q
A
L
D
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
--------
E
-
I
K
E
E
V
K
----
K
I
I
D
S
R
I
E
E
L
--
E
K
V
L
----
I
G
V
A
Y
L
G
E
L
T
P
K
------
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
-
D
--
M
E
-------
M
S
D
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
-------
S
Q
---
G
S
-------
S
--
E
-----
T
--
N
I
S
L
V
V
------
S
E
ED
V
D
K
A
L
K
A
L
K
R
E
F
G
D
-----------
S
F
L
N
N
N
L
----
I
----
R
D
V
S
-
V
D
-----
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
---------
44
Fugue
76.82
26%
-92
- C1 -
2CDQ
5
AK1_ARATH
A:
[25-494]
KGI
T
C
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
-
F
P
---
E
E
S
---
P
V
I
V
L
S
A
M
G
K
T
T
N
N
L
L
L
A
G
E
K
A
V
S
C
---
G
V
S
N
A
S
E
I
E
E
L
S
I
------
I
K
E
L
H
I
R
T
V
K
E
L
N
I
D
P
--------
S
-
V
I
L
T
Y
L
----
E
----
E
L
E
Q
L
--
L
K
G
I
----
A
------
M
M
K
E
L
T
L
R
---
T
R
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
-
D
F
T
N
G
-
D
I
L
E
A
T
-
Y
-----
P
A
----
V
A
K
R
L
Y
-----
D
D
W
------
M
H
DP
A
V
P
I
V
T
-
G
F
L
G
K
-
G
W
K
-
T
G
A
-
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
N
S
Y
N
P
K
A
P
G
T
I
I
T
K
-
T
--
R
D
-------
M
T
K
S
------
I
L
-----
T
S
I
V
L
K
R
N
V
T
M
L
D
I
A
S
T
R
M
L
G
Q
V
G
--
F
L
A
K
V
F
S
I
F
--
E
E
L
G
I
S
V
D
-------
V
V
---
A
T
-------
S
--
E
-----
V
--
S
I
S
L
T
L
------
D
P
-----------
S
K
L
W
S
--
R
E
---
L
I
Q
Q
E
L
D
-
H
V
V
----
E
----
E
L
E
K
-
I
A
V
V
N
L
L
K
G
--
R
A
I
I
S
L
I
G
-
N
V
Q
H
S
S
L
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
M
I
S
Q
G
A
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
GDLSELLIQ
7
PsiBlast_PDB
76.25
26%
-89
- C1 -
2J0X
3
AK3_ECOLI
A:
[6-449]
-----
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
-
D
A
---
N
V
R
---
L
V
V
L
-
S
A
S
A
G
-------
I
T
N
L
L
V
A
L
---
A
E
G
L
E
P
G
E
R
F
E
K
L
D
---
A
-
I
R
N
I
Q
F
A
I
L
E
R
L
R
Y
P
N
--------
V
-
I
R
E
E
I
E
----
R
----
L
L
E
N
I
--
T
V
L
A
E
A
A
A
L
------
A
T
S
P
A
------
L
T
D
E
L
V
S
H
G
E
L
M
S
T
L
L
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
---
V
M
R
T
-
N
D
R
F
G
-
R
A
E
P
D
I
-
A
-----
A
L
----
A
E
L
A
A
L
Q
L
L
P
R
L
N
E
------
G
-----
L
V
I
T
Q
G
F
I
G
S
-
E
-
N
-
K
G
R
-
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
S
S
K
D
P
R
A
G
G
T
-
L
V
C
-
N
--
K
T
-------
E
N
P
P
------
L
F
-----
R
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
S
L
N
M
L
H
S
R
G
--
F
L
A
E
V
F
G
I
L
--
A
R
H
N
I
S
V
D
-------
L
I
---
T
T
-------
S
--
E
-----
V
--
S
V
A
L
T
L
------
D
T
-----------
T
G
S
T
S
--
T
G
---
D
--
T
L
L
T
-
Q
S
L
----
L
----
M
E
L
S
A
L
C
R
V
E
V
E
E
G
--
L
A
L
V
A
L
I
G
N
D
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
--
E
P
F
N
I
R
M
I
C
Y
G
A
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
E
----------
8
PsiBlast_PDB
75.13
26%
-84
- C1 -
2J0W
4
AK3_ECOLI
A:
[6-449]
-----
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
-
D
A
---
N
V
R
---
L
V
V
L
-
S
A
S
A
G
-------
I
T
N
L
L
V
A
L
---
A
E
G
L
E
P
G
E
R
F
E
K
L
D
---
A
-
I
R
N
I
Q
F
A
I
L
E
R
L
R
Y
P
N
--------
V
-
I
R
E
E
I
E
----
R
----
L
L
E
N
I
--
T
V
L
A
E
A
A
A
L
------
A
T
S
P
A
------
L
T
D
E
L
V
S
H
G
E
L
M
S
T
L
L
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
---
V
M
R
T
-
N
D
R
F
G
-
R
A
E
P
D
I
-
A
-----
A
L
----
A
E
L
A
A
L
Q
L
L
P
R
L
N
E
------
G
-----
L
V
I
T
Q
G
F
I
G
S
-
E
-
N
-
K
G
R
-
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
S
S
K
D
P
R
A
G
G
T
-
L
V
C
-
N
--
K
T
-------
E
N
P
P
------
L
F
-----
R
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
S
L
N
M
L
H
S
R
G
--
F
L
A
E
V
F
G
I
L
--
A
R
H
N
I
S
V
D
-------
L
I
---
T
T
-------
S
--
E
-----
V
--
S
V
A
L
T
L
------
D
T
-----------
T
G
S
T
S
--
T
G
---
D
--
T
L
L
T
-
Q
S
L
----
L
----
M
E
L
S
A
L
C
R
V
E
V
E
E
G
--
L
A
L
V
A
L
I
G
N
D
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
--
E
P
F
N
I
R
M
I
C
Y
G
A
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
E
----------
43
Fugue
75.07
27%
-87
- C1 -
3C1M
6
AK_METJA
A:
[2-470]
---
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
-
R
K
---
K
E
D
D
D
V
V
V
V
V
-
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
V
---
R
D
I
A
K
V
G
D
F
I
K
F
I
R
---
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
--------
E
-
V
K
K
I
I
D
----
S
----
R
I
E
E
L
--
E
K
V
L
----
I
------
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
-
N
F
G
S
A
R
V
K
R
L
E
V
-
K
-----
E
R
----
L
L
P
L
L
K
-----
E
G
I
------
I
-----
P
V
V
T
-
G
F
I
G
T
-
T
-
E
-
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
-
D
--
M
E
-------
M
S
D
S
------
I
V
-----
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
M
V
G
V
S
G
--
T
A
A
R
I
F
K
A
L
--
G
E
E
E
V
N
V
I
-------
L
I
---
S
Q
-------
G
--
S
-----
S
ET
N
I
S
L
V
V
------
S
E
-----------
E
D
V
D
K
--
A
L
K
A
L
K
--
R
E
F
G
-
D
S
F
----
L
----
N
N
N
L
-
I
R
D
V
S
V
D
K
D
--
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
---------
23
HHSearch
72.09
26%
-83
- C1 -
2CDQ
5
AK1_ARATH
A:
[28-485]
---
T
C
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
-
F
P
E--
E
S
P
---
V
I
V
L
-
S
A
M
G
K
T
T
N
N
L
L
L
A
G
E
K
A
V
S
C
---
G
---
V
S
N
A
S
E
I
E
E
L
---
S
I
I
K
E
L
H
I
R
T
V
K
E
L
N
I
D
P
--------
S
V
I
L
T
Y
L
E
----
E
----
L
E
Q
L
L
K
G
I
A
M
M
----
K
------
E
L
T
L
R
------
T
R
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
D
F
T
N
-
G
-
D
I
L
E
A
T
-
Y
P
A
V
A
K
R
L
----
Y
D
D
W
M
H
-----
D
P
A
------
V
-----
P
I
V
T
-
G
F
L
G
K
-
G
-
W
K
T
G
A
-
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
N
S
Y
N
P
K
A
P
G
T
I
I
T
K
T
R
--
D
M
--------
T
K
S
------
I
L
-----
T
S
I
V
L
K
R
N
V
T
M
L
D
I
A
S
T
R
M
L
G
Q
V
G
--
F
L
A
K
V
F
S
I
F
--
E
E
L
G
I
S
V
D
-------
V
V
---
A
T
-------
S
--
E
-----
V
--
S
I
S
L
T
L
------
D
P
-----------
S
K
L
W
S
--
R
E
-------
L
I
Q
-
Q
E
L
D
H
V
V
E
----
E
L
E
K
-
I
A
V
V
N
L
L
K
G
--
R
A
I
I
S
L
I
G
N
V
-
Q
H
S
S
L
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
M
I
S
Q
G
A
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
---------
26
HHSearch
71.44
30%
-94
- C1 -
3L76
5
?
A:
[3-417]
---
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
-
T
V
Q
G
G
N
S
L
---
V
V
V
V
-
S
A
M
G
K
S
T
D
V
L
V
D
L
A
Q
Q
I
-------------------------------------
S
-------------------------------------------
P
------
N
P
C
R
R
------
E
M
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
---------
I
L
E
I
R
-
P
-----
D
R
----
L
E
H
H
L
R
-----
E
G
K
------
V
-----
V
V
V
A
-
G
F
Q
G
I
-----
H
L
E
-
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
D
E
-
P
G
T
K
V
V
A
P
P
--
V
Q
NRSLVGL
E
I
A
K
------
A
V
-----
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
R
--
V
P
D
R
P
G
--
V
A
S
K
L
F
R
D
I
--
A
Q
Q
Q
V
D
I
D
-------
L
I
---
I
Q
-------
S
--
I
HDGN
S
N
--
D
I
A
F
T
V
------
V
K
-----------
D
L
L
N
T
--
A
E
---
A
V
T
S
A
I
A
-
P
A
L
RSY-
P
----
E
A
D
Q
-
E
A
E
I
I
V
E
K
G
--
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
---------
22
HHSearch
69.19
24%
-75
- C1 -
2J0W
4
AK3_ECOLI
A:
[4-449]
---
I
V
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
-
D
A
---
N
V
R
---
L
V
V
L
-
S
A
S
A
G
I
T
N
L
L
V
A
L
A
E
G
L
----------
E
P
G
E
R
-
F
E
K
L
---
D
A
I
R
N
I
Q
F
A
I
L
E
R
L
R
Y
P
N
--------
V
-
I
R
E
E
I
E
R
L
L
E
N
----
I
T
V
L
A
--
E
A
A
A
----
L
------
A
T
S
P
A
------
L
T
D
E
L
V
S
H
G
E
L
M
S
T
L
L
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
V
M
R
T
N
D
R
-
F
G
R
A
E
-
P
D
I
A
A
L
-
A
-----
E
L
A
A
L
Q
L
L
P
R
L
N
-----
E
G
-------
L
-----
V
I
T
Q
-
G
F
I
G
S
-
E
-
N
-
K
G
R
-
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
S
S
K
D
P
R
A
G
G
T
L
V
C
N
K
T
--
E
---------
N
P
P
------
L
F
-----
R
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
S
L
N
M
L
H
S
R
G
--
F
L
A
E
V
F
G
I
L
--
A
R
H
N
I
S
V
D
-------
L
I
---
T
T
-------
S
--
E
-----
V
--
S
V
A
L
T
L
------
D
T
-----------
T
G
S
T
S
--
T
G
---
D
--
T
L
L
T
-
Q
S
L
L
---
M
----
E
L
S
A
-
L
C
R
V
E
V
E
E
G
--
L
A
L
V
A
L
I
G
N
D
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
E
--
P
F
N
I
R
M
I
C
Y
G
A
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
E
----------
9
PsiBlast_PDB
63.96
28%
-95
- C1 -
3AAW
3
AK_CORGL
A:
[67-405]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
---------------------
V
T
-
P
-----
G
R
----
V
R
E
A
L
D
-----
E
G
K
------
I
-----
C
I
V
A
-
G
F
--
V
-
N
-
K
-
E
T
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
D
P
G
T
--
L
I
-
A
--
G
S
-------
M
E
D
I
------
P
V
EE
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
I
S
D
K
P
G
--
E
A
A
K
V
F
R
A
L
--
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
S
V
---
E
D
-------
G
--
T
-----
T
--
D
I
T
F
T
C
------
P
R
-----------
S
D
G
R
----
R
---
A
--
M
E
I
L
-
K
K
L
----------
Q
V
Q
-
G
N
W
T
N
V
L
Y
D
DQ
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
---------
6
PsiBlast_PDB
56.80
29%
-87
- C1 -
3L76
5
?
A:
[66-416]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
---------
I
L
E
I
R
-
P
-----
D
R
----
L
E
H
H
L
R
-----
E
G
K
------
V
-----
V
V
V
A
-
G
F
Q
G
I
-----
H
L
E
-
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
-
D
E
P
G
T
K
V
V
A
-
P
PV
Q
N
-------
R
S
L
V
GLEIAK
A
V
-----
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
R
V
P
D
R
P
G
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
--
V
D
I
D
L
I
I
Q
-------
S
I
---
H
D
-------
G
N-
S
-----
N
--
D
I
A
F
T
V
VKDL
L
N
T
A
-----------
E
A
V
T
S
--
A
I
---
A
--
P
A
L
R
-
S
Y
P
----
E
----
A
D
Q
E
-
A
E
I
I
-
V
E
K
G
--
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
---------
10
PsiBlast_PDB
52.13
27%
-110
- C1 -
2RE1
2
?
A:
[15-164]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-----
T
G
I
A
F
D
K
N
Q
A
R
I
N
V
R
G
--
V
P
D
K
P
G
--
V
A
Y
Q
I
L
G
A
V
--
A
D
A
N
I
E
V
D
-------
M
I
I
Q
N---------
G
--
T
-----
T
--
D
F
S
F
T
V
------
P
R
-----------
G
D
Y
K
----
Q
---
T
--
L
E
I
L
-
S
E
R
----
Q
----
D
S
I
G
-
A
A
S
I
D
G
D
D
T
--
V
C
K
V
S
A
V
G
L
G
M
R
S
H
V
G
V
A
A
K
I
F
R
T
L
A
E
E
G
I
N
I
Q
M
I
S
--
T
S
E
I
K
V
S
V
L
I
D
E
K
Y
M
E
L
A
T
R
V
L
H
K
A
F
N
L
----------
13
PsiBlast_PDB
46.97
23%
-100
- C1 -
4GO7
1
X:
[26-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
T
G
V
A
H
D
R
S
E
A
K
V
T
I
V
G
--
L
P
D
I
P
G
--
Y
A
A
K
V
F
R
A
V
--
A
D
A
D
V
N
I
D
MVLQNVS
K
-----
D
-------
G
--
K
-----
T
--
D
I
T
F
T
C
-------
S
-----------
R
D
V
G
P
---
A
---
A
--
V
E
K
L
-
D
S
L
----
R
----
N
E
I
G
-
F
S
Q
L
L
Y
D
D
H
--
I
G
K
V
S
L
I
G
A
G
M
R
S
H
P
G
V
T
A
T
F
C
E
A
L
A
A
V
G
V
N
I
E
L
I
S
--
T
S
E
I
R
I
S
V
L
C
R
D
T
E
L
D
K
A
V
V
A
L
H
E
A
F
G
L
E
---------
15
PsiBlast_PDB
46.76
23%
-97
- C1 -
3S1T
6
AK_MYCTU
A:
[7-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
T
G
V
A
H
D
R
S
E
A
K
V
T
I
V
G
--
L
P
D
I
P
G
--
Y
A
A
K
V
F
R
A
V
--
A
D
A
D
V
N
I
D
M
V
L
Q
N
V
S
K
V
---
E
D
-------
G
--
K
-----
T
--
D
I
T
F
T
C
-------
S
-----------
R
D
V
G
P
---
A
---
A
--
V
E
K
L
-
D
S
L
----
R
----
N
E
I
G
-
F
S
Q
L
L
Y
D
D
H
--
I
G
K
V
S
L
I
G
A
G
M
R
S
H
P
G
V
T
A
T
F
C
E
A
L
A
A
V
G
V
N
I
E
L
I
S
--
T
S
E
I
R
I
S
V
L
C
R
D
T
E
L
D
K
A
V
V
A
L
H
E
A
F
G
L
G
---------
45
Fugue
46.33
28%
-94
- C1 -
2DTJ
2
AK_CORGL
A:
[4-167]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------
V
L
-----
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
P
G
--
E
A
A
K
V
F
R
A
L
--
A
D
A
E
I
N
I
D
-------
M
V
---
L
Q
N
V
SSVED
G
--
T
-----
T
--
D
I
T
F
T
C
------
P
R
-----------
S
D
G
R
----
R
---
A
--
M
E
I
L
-
K
K
L
----
Q
----
V
Q
G
N
-
W
T
N
V
L
Y
D
D
Q
--
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
T
S
--
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
GEDEAVVY-