@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0351: (2015-11-30 )
MKVKLFAIHLFFIVISFGIKYYHLQGPNLIWNMTLALIALDFAYLTSLFKKKILIGLFALAWFFFYPNTFYMLTDIIHMHFVGDVLYNKTNLILYILYVSSILFGFLSGIESFSVIMRKFRISNIFLRWGIIGIVSFVSSFGIHIGRYARLNSWDILTKPQVVINELLAVPSRDSFHFILGFTFLQVLCLIFMDYSAGKKLEK
Atome Classification :
(19 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10......-..20....-------....30.......-.40...------------.....50-----.....------------...60........70.----..--------.....----------80.....--.----------------------------..90........100---.....------...110......-.120.-----------------..---.--...------130---.-.....------------..140....------...150-----.......------160.......170----------.........180..-----.......190--.........-200.------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
V
K
L
F
A
I
H
L
F
F
I
V
I
SF-G
I
K
Y
Y
HLQ-------GP
N
L
I
W
N
M
T
L
A
L
I
-
A
L
D
F
A
Y
------------
L
T
S
L
F
K
K
-----
K
I
L
I
G
------------
L
F
A
L
A
W
F
F
FYP
N
T
F
Y
M
----
L
T
--------
D
I
I
H
M
----------
H
F
V
G
D
V
L--Y----------------------------NKT
N
L
I
L
Y
I
L
Y
V
S
S
----
I
L
F
G
F
------
L
S
G
I
E
S
F
S
V
I
M
R
-
K
F
R
I
S
-----------------
N
I
---
F
--
L
R
W
------
G
I
----
I
-
G
I
V
S
F
------------
V
S
S
FGIHIG------
R
Y
A
RLN-----SWDILTK------
P
Q
V
V
I
N
E
L
LAV------------PSRD
S
F
H
F
I
L
--
G
F
-----
T
F
L
Q
V
L
C
L
----
I
F
MDYSAGK-KLEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
82.04
18%
-198
- C5 -
3BGY
3
MCE_MIMIV
A:
[12-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
I
F
S
E
N
E
Y
N
E
I
V
E
M
-
L
R
D
Y
S
N
---------
G
D
N
L
E
F
E
V
S
F
K
N
I
N
Y
P
N
F
M
R
------------
I
T
E
H
Y
I
N
I
TPEN
K
I
E
S
N
------------
N
Y
L
D
I
S
L
I
F
P
D
K
N
V
Y
R
----
V
S
L
FN
Q
E
Q
I
G
E
F
I
T
K
F
S
KAS
S
N
D
I
S
R
Y
I
V
S
L
D
--
P
----------------------------
S
D
D
I
E
I
V
Y
K
N
R
G
S
G
----
K
L
I
G
I
D
NWA
I
T
I
K
S
T
E
E
I
P
L
V
A
G
-
K
S
K
I
S
-----------------
K
P
---
K
--
I
T
G
------
S
E
----
R
-
I
M
Y
R
Y
------------
K
T
R
Y
S
F
T
I
N
------
K
N
S
R
I
D
-----
I
T
D
V
K
S
S
------
P
--
I
I
W
K
L
M
T
V
------------
P
S
N
Y
E
L
E
L
E
L
--
I
N
K
I
D
I
N
T
L
E
S
E
L
L
N
----
V
F
M
I
I
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
80.13
16%
-152
- C7 -
3L56
-
?
B:
[541-745]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
E
S
V
L
V
N
T
Y
Q
W
I
I
R
N
W
E
T
V
K
I
Q
W
S
Q
-------
D
P
T
M
L
Y
N
K
-------
M
E
F
E
P
------------
F
Q
S
L
V
P
K
-----
A
A
R
G
Q
------------
Y
S
G
F
V
R
T
L
F
Q
Q
M
R
D
V
L
GTFD
T
V
--------
Q
I
I
K
L
----------
L
P
F
A
A
A
P
--
P
----------------------------
K
Q
S
R
M
Q
F
S
S
L
T
V
N
V
----
R
G
S
G
M
------
R
I
L
V
R
G
N
S
P
V
F
N
-
Y
N
K
A
T
-----------------
K
R
---
L
--
T
V
L
------
G
K
----
D
A
G
A
L
T
E
------------
D
P
D
E
G
T
A
G
V
------
E
S
A
V
L
R
-----
G
F
L
I
L
G
K
EDKRYG
P
A
L
S
I
N
E
L
S
N
L
------------
A
K
G
E
K
A
N
V
L
I
--
G
---------
Q
G
D
V
V
----
L
V
M
K
R
K
R
D
S
-
S
I
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
79.01
15%
-142
* C8 *
2L5A
-
CENPA_YEAST (first)
A:
[1-225]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
S
K
I
P
F
A
R
L
V
K
E
-
V
T
D
E
F
T
T
K
-------
D
Q
D
L
R
W
-
Q
S
M
A
I
M
-
A
L
Q
E
A
S
------------
E
A
Y
L
V
G
L
-----
L
E
H
T
N
------------
L
L
A
L
----
H
A
K
R
I
T
I
M
----
K
K
--------
D
M
Q
L
A
----------
R
R
I
R
G
Q
F
--
L
VPRG------------------------
S
M
E
R
H
K
L
A
D
E
N
M
R
K
----
V
W
S
N
I
------
I
S
K
Y
E
S
I
E
E
Q
G
D
-
L
V
D
L
K
TGEIVEDNGHIKTLTAN
N
S
---
T
--
K
D
K
------
R
T
----
K
-
Y
T
S
V
L
------------
R
D
I
I
D
I
S
D
E
------
E
D
G
D
K
G
GVKRI
S
G
L
I
Y
E
E
------
V
R
A
V
L
K
S
F
L
E
S
------------
V
I
R
D
S
V
T
Y
T
E
H
A
K
R
-----
K
T
V
T
S
L
D
V
----
V
Y
A
L
K
R
Q
G
R
-
T
L
Y
G
FGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
77.25
23%
-128
- C7 -
4YHC
2
SCAP_SCHPO
A:
[2-468]
GWSD
H
D
E
L
S
TDTT
L
H
E
E
K
F
R
I
E
P
VPVHHQLDIL
K
I
A
V
S
ENYK
T
F
A
S
V
G
LDR
S
L
V
V
W
DLRQWCTK
L
V
L
S
KEQMPRTLK
A
I
A
L
D
PQGN
Y
V
S
L
F
S
KD
T
L
F
I
L
N
VESPSLM
L
Q
H
S
Y
H
S
KPN
S
K
L
N
V
F
W
M
P
G
THKDDE
W
K
N
F
E
L
V
V
V
E
SSG
E
I
Q
V
F
S
L
T
I
E
IE
G
A
D
I
A
LV
E
K
F
Q
L
SSPII
K
S
I
S
I
V
S
P
T
A
N
R
I
A
S
L
T
E
S
G
-
E
V
T
V
Y
S
K
K
-------
G
P
--
V
W
S
P
K
I
--
L
-
S
Q
N
K
N
Y
------------
L
T
E
--
T
K
-----
K
D
I
Y
G
------------
I
A
M
A
D
I
L
F
L
A
R
D
S
G
-------
V
--------
D
M
I
D
L
-------------------------------------------------
K
N
D
E
L
L
H
S
F
T
L
P
P
----
I
K
V
N
T
------
F
S
V
G
V
S
N
S
R
F
V
N
G
Q
F
R
V
S
-----------------
S
I
---
S
--
F
C
F
T
H----
A
V
----
T
-
E
K
V
L
Y
------------
Y
Y
Y
G
N
E
S
N
E
------
S
Y
I
I
L
N
-----
K
W
D
--
Q
Q
------
P
-----
N
L
V
D
V
------------
H
D
P
D
N
S
L
A
S
L
--
T
F
-----
D
E
L
Q
E
N
I
H
----
E
V
E
D
A
S
E
S
V
-
M
S
S
D
GL
Y
I
F
G
M
R
R
K
S
S
S
G
ISG
E
T
Q
V
W
E
V
W
M
Y
SQSEK
K
H
R
S
K
S
L
K
M
Y
NSLIIADPGPSLAVSDR
C
V
A
I
V
LGN
Y
V
A
L
V
G
Y
GSEIFR----------------------------------------------------------------------------------------------------------------------------
11
Fugue
76.07
17%
-126
* C9 *
4GA6
3
AMPPA_THEKO
A:
[1-493]
------------------------------------------------------------------M
K
A
K
I
R
I
L
DMFSGRY
T
V
L
I
N
E
E
D
A
K
E
A
KLHPDD
L
V
K
I
E
A
G
K
K
A
V
Y
G
S
V
A
L
S
NLVGKG
E
V
G
I
S
RDVLDL
H
N
F
S
EGE
T
V
S
V
I
P
A
G
TP
E
S
V
R
Y
I
K
K
K
M
H
G
E
K
L
R
K
V
E
I
E
A
I
V
R
D
I
V
D
R
K
L
R
D
I
E
I
S
S
F
V
T
A
L
-
E
I
N
------------
G
L
D
M
D
E
I
A
A
L
T
I
A
-
M
A
E
T
G
D
------------
M
L
D
I
D
R
K
-----
P
I
-----------------------------------------------
M
D
V
----------
H
S
I
G
G
V
P
--
G
----------------------------
N
K
T
N
I
L
V
V
P
I
V
A
A
A
----
G
L
T
I
P
------
K
T
S
S
R
A
I
T
S
A
A
G
-
T
A
D
V
V
-----------------
E
V
---
F
AD
V
S
F
------
S
L
----
D
-
E
I
K
R
I
------------
V
E
K
V
G
A
C
L
V
------
W
G
G
A
L
N
---------
L
A
P
------
A
D
D
I
T
I
K
A
E
R
A
------------
L
S
I
D
P
T
G
L
M
L
--
A
S
-----
I
M
S
K
K
Y
A
M
GSQ
Y
V
L
I
D
I
P
T
G
K
-
G
V
K
V
ET
V
E
E
A
R
S
L
A
R
D
F
I
E
L
G
K
R
L
G
Q
Y
V
E
V
A
ITYGGQPIGHTVGP
A
L
E
A
R
E
A
L
S
A
L
M
T
GKGP
G
S
L
I
E
K
A
T
G
L
A
G
I
L
L
E
M
G
GVAPAGT
G
K
K
M
A
K
E
I
L
E
S
G
K
A
W
E
K
M
K
E
I
I
E
A
Q
GGDPNIKPEEIPIGD
K
T
Y
T
F
T
AA
T
S
G
Y
VTAID
N
R
A
I
T
A
I
A
R
A
A
GAPEDKG
A
G
I
E
L
YVKVG
E
K
V
K
EGDPL
F
T
I
H
A
EH
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
EPIRIE
13
Fugue
75.27
15%
-120
* C7 *
1QQH
-
VE2_HPV18
A:
[66-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
K
A
H
K
A
I
E
L
Q
M
A
L
Q
G
L
-
A
Q
S
A
Y
K
T
E
-------
D
----
W
T
L
Q
D
T
C
E
-
E
L
W
N
T
E
------------
P
T
H
C
F
K
K
-----
G
-------------------------------------
G
--------
Q
T
V
Q
V
----------
Y
F
D
G
N
K
D
--
N
----------------------------
C
M
T
Y
V
A
W
D
S
V
Y
Y
M
T
-------------------
D
A
G
T
W
D
K
T
-
A
T
C
V
S
-----------------
H
R
---
G
--
L
Y
Y
------
V
K
----
E
-
G
Y
N
T
F
------------
Y
I
E
F
K
S
E
C
E
------
K
Y
G
N
T
G
-----
T
W
E
V
H
F
G
------
N
N
V
I
D
C
N
D
S
M
C
------------
S
T
S
D
D
T
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
74.31
17%
-121
- C6 -
4TWK
9
KCNK2_HUMAN
A:
[14-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
I
N
V
M
K
W
K
T
V
S
T
I
F
L
V
V
V
L
Y
L
I
I
G
A
-
T
V
F
K
A
L
E
Q
-------
P
H
E
I
S
Q
R
T
T
I
V
I
Q
-
K
Q
T
F
I
S
Q
H
SCVN
S
T
E
L
D
E
L
I
Q
Q
I
V
A
-----
A
I
N
A
G
IIPLGNTSNQIS
H
W
D
L
G
S
S
F
F
F
A
G
T
V
I
------
T
--------
T
I
G
F
G
----------
N
I
S
P
R
T
E
--
G
----------------------------
G
K
I
F
C
I
I
Y
A
L
L
G
I
P
----
L
F
G
F
L
------
L
A
G
V
G
D
Q
L
G
T
I
F
-
G
K
G
I
A
-----------------
K
V
E
D
T
F
--
I
K
W
------
N
V
S
Q
T
K
I
-
R
I
I
S
T
------------
I
I
F
I
L
F
G
C
V
------
L
F
V
A
L
P
-----
G
W
S
A
L
D
A
------
I
Y
F
V
V
I
T
L
T
T
I
GFGDYVAGGSDI
K
P
V
V
W
F
W
I
L
V
--
G
L
-----
A
Y
F
A
A
V
L
S
----
M
I
G
D
W
L
R
V
I
-
S
A
E
N
L
YF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
67.40
16%
-192
- C7 -
2OST
1
?
A:
[1-148]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGST
K
L
K
G
D
I
A
Q
Q
A
A
I
M
R
A
L
K
M
-
G
W
G
V
L
K
P
L
-------
G
D
R
L
S
Y
D
L
V
F
D
V
-------------------------
E
G
-----
I
L
L
K
V
------------
Q
V
K
S
S
W
K
S
E
K
T
G
N
Y
V
V
----
D
N
--------
R
R
T
R
T
----------
N
R
R
N
I
V
R
S
P
Y
----------------------------
R
G
N
D
F
D
F
A
V
A
Y
V
E
------------------
E
L
E
L
F
Y
V
F
P
------
V
-----------------
D
V
---
F
--
I
S
Y
------
G
-------
S
E
I
H
L
------------
V
E
T
D
K
R
Q
------------------------
R
K
------
P
R
-------
S
F
------------
G
Y
R
E
A
W
H
L
I
L
--
Q
K
------------------------
G
A
-
A
Q
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
61.29
12%
-145
- C8 -
4AKS
-
?
A:
[514-851]
---------------------------------------------------------------------------------------------------------------------------------------------------------------KVALHPHDLDERIPG
L
A
D
L
H
N
Q
T
L
G
D
P
Q
I
T
I
V
I
I
D
G
-
D
P
D
Y
T
L
S
C
FEGAE
V
S
K
V
F
P
Y
W
H
E
P
A
E
P
I
T
P
E
D
Y
A
A
------------
F
Q
S
I
R
D
Q
-----
G
L
K
G
K
------------
E
K
E
E
A
L
E
A
V
I
P
D
T
K
D
R
----
I
V
--------
L
N
D
H
A
----------
C
H
V
T
S
T
I
--
V
GQEHSPVFGIAPN
C
R
V
I
N
MPQDAVIRVM
S
P
L
N
L
A
R
A
I
D
L
A
L
E
L
GAN
I
I
H
C
A
------
F
C
E
E
I
L
V
Q
A
I
K
K
-
C
Q
D
N
N
-----------------
V
L
---
I
--
V
S
P
TGNVLP
G
T
----
L
-
A
V
G
A
A
K
VDGTPCNTKE
G
I
L
A
P
G
E
E
I
L
G
A
Q
P
CT
E
E
P
V
R
L
-----
T
G
T
S
M
A
A
------
P
V
M
T
G
I
S
A
L
L
M
------------
S
L
Q
V
Q
Q
G
K
P
V
--
D
A
-----
E
A
V
R
T
A
L
L
----
K
T
A
I
P
L
R
G
F
V
N
I
P
G
A
M
K
V
L
FGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
44.47
29%
52
- C10 -
3HRL
-
?
A:
[69-99]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
G
F
---------
T
V
L
R
F
W
-----
N
H
E
I
L
Q
Q
------
T
N
D
V
L
A
E
I
L
R
V
------------
L
Q
E
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
40.48
20%
297
- C10 -
1AVO
-
?
B:
[222-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
----
A
V
L
Y
D
I
I
L
K
-
N
F
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
39.62
31%
-118
- C9 -
4PJ0
-
PSBT_THEEB
T:
[1-29]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
------------
I
T
Y
V
F
I
F
-----
A
C
I
I
A
------------
L
F
F
F
A
I
F
F
R
E
P
P
R
I
N
L
----
W
E
--------
R
F
C
N
W
----------
V
T
S
T
D
N
R
--
L
----------------------------
Y
V
G
W
F
G
V
I
M
I
P
T
L
L
----
A
A
T
I
C
------
F
V
I
A
F
I
A
A
P
P
V
D
-
I
D
G
I
R
-----------------
E
P
---
V
--
S
G
S
------
L
L
----
Y
-
G
N
N
I
I
------------
T
G
A
V
V
P
S
S
N
------
A
I
G
L
H
F
-----
Y
P
I
W
E
A
A
------
S
L
D
E
W
L
Y
N
G
G
P
------------
Y
Q
L
I
I
F
H
F
L
L
--
G
A
-----
S
C
Y
M
G
R
Q
W
----
E
L
S
Y
R
L
G
M
R
-
P
W
I
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
37.85
40%
282
- C10 -
3ECH
-
?
C:
[8-22]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
------
R
A
A
R
R
N
-----
A
W
D
L
Y
G
E
------
H
F
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
29.26
22%
24
- C4 -
3BMA
1
?
A:
[339-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
E
P
F
F
----
M
K
--------
D
T
I
H
L
----------
G
W
L
G
W
L
A
--
F
----------------------------
D
K
A
V
D
P
F
L
S
N
P
T
P
A
----
P
T
Y
H
L
------
N
E
R
F
F
S
K
D
W
A
T
Y
-
D
G
D
V
K
-----------------
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
HHSearch
26.52
42%
392
* C10 *
2J5D
-
BNIP3_HUMAN
A:
[176-187]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
L
G
I
Y
I
G
------
R
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
24.27
13%
275
- C10 -
2K3C
-
?
A:
[338-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
M
A
Y
L
----
S
A
--------
E
L
F
H
L
----------
S
G
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
20.80
43%
834
- C3 -
2KET
-
A:
[1-7]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
R
F
K
R
F
R
-----
K
K
F
K
K
L
F
------
K
K
L
S
P
V
I
P
L
L
H
------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
16.14
30%
575
- C1 -
2ZVV
1
Y:
[9-18]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
--------
D
F
Y
H
S
----------
K
R
R
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
4.64
43%
1629
- C2 -
1N0X
1
?
P:
[4-9]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
M
----
F
S
--------
D
L
E
N
R
----------
C
I
A
A
E
R
N
--
K
----------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------