@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0376: (2015-11-30 )
MSFPSAYSLELGTDLSAKEAYDFSRTPVGSPHHLTDAKKFQCGEKCPFKLTLANFNNPDFNKTPYFTPGARNQEHNPDYCQRMIEHYRQREQETTIENHICFSREKNQLIIDLDLVKGTLAIVTQPRQKDEDIPSSETSHTEVTHRHSRSSSTIDNTTFRSHIKQLTALIRYFLEYQSGEKYTFYSKNKQEIQLERYFVNLAASGQRGVNLEDVHIYYDTATVDYHLDEDNPDNSYFLIRFHHVCSIDNINNRPTIIINETKAQHRGVGYKIKILKRAAKDSEPLKVFFFGSFIKHPNRKFINPNVSPIDILDYLVFS
Atome Classification :
(18 SA)
---------------------------.........10--.........20.-----.....---..30.......--.40........50...-.....60........70......-----..80........90.......--.100...------....110.......120..----.....130.......140.....----..150.....-..160........-----170.......180.....----..190.......200.......210-----.......220.......230-----....--....240.......250.---......-----260.......270..------.....280....------...290-------------.......-------..300.-----......310......-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MSFP
S
A
Y
S
L
E---LGTDLS
A
K
E
AYD-----FSRTP---VGSPHHLTD
A
K
--KFQCGEKC
P
F
K
L
T
LAN-FNNPDFNKTPYFTPGARNQEH
N
P
-----
D
Y
C
Q
R
M
I
E
H
Y
R
Q
R
E
Q
ETTIEN--
H
I
C
FSRE------K
N
Q
L
I
I
D
L
DLVK
G
T
L
A
I
V
T----QPRQKDEDIPSSETSH
T
E
V
T
H
RH----SRSSSTID
N
T
-
T
F
R
-
S
H
I
K
Q
L
T
A
L
-----
I
R
Y
F
L
E
YQSGE
K
Y
T
F
YSK----N
K
Q
E
I
Q
L
E
R
Y
F
V
N
LAASGQRGVNL
E
-----
D
V
H
I
Y
Y
D
T
A
T
V
D
Y
HLDEDN------PDN
S
--
Y
F
L
I
R
F
H
H
V
C
S
IDNINNR---
P
T
I
I
I
N-----ETKAQHRGV
G
Y
K
I
K
I
------
L
K
R
AAKDSE
P
L
K
------
V
F
F
F
---------------
G
S
F
IKHP-------NRKFIN-----PNV
S
P
I
D
I
L
D
Y
L
VFS-------
15
Fugue
74.28
14%
-2
- C4 -
3J6V
-
RT05_BOVIN
E:
[89-430]
----------------------------------------
F
F
T
K
L
T
A
D
E
L
W
K
-----
G
A
L
A
E
---
T
G
A
G
A
R
K
G
R
G
K
--
R
----
T
K
R
K
R
R
K
D
L
N
R
-
G
Q
I
I
G
E
G
R
R
G
F
L
W
P
G
L
N
A
P
L
M
K
S
-----
G
A
I
Q
T
I
T
Q
--
R
S
K
E
E
Q
E
K
V
E
A
--
D
M
V
Q
Q
R
E
EWDRKR
K
M
K
V
K
R
E
R
G
W
S
G
N
S
W
G
G
I
S
LGPP
D
P
G
P
N
G
E
T
Y
D
D
F
D
T
R
I
L
E
V
R
N
V
F
----
N
M
T
A
----
K
E
-
G
R
K
-
R
S
V
R
V
L
V
A
V
GNGRG
A
A
G
F
A
I
G
K
A
T
E
R
A
D
A
F
R
K
----
A
K
N
R
A
V
H
Y
L
H
Y
I
E
R
---
Y
E
D
H
T
I
Y
H
-----
D
I
S
L
T
F
K
R
T
H
I
K
M
K
K
Q
P
R
G
------
Y
G
L
R
CH
R
A
I
T
T
I
C
R
L
I
G
I
K
D
M
Y
A
K
VSG
S
V
N
M
L
S
-----
L
T
R
G
L
F
Q
G
L
S
R
Q
E
--------
T
H
Q
Q
L
A
D
K
K
S
L
H
------
V
V
E
F
REECGPLPIVVASPQ
G
A
L
R
K
D
P
EPEDEVP
D
I
K
L
D
W
-----
D
D
V
K
A
V
Q
G
M
K
R
S
V
W
S
GLKRAAT
19
Fugue
71.58
17%
-13
- C4 -
4D7E
1
?
A:
[1-413]
ME
T
L
L
V
VGAG
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
G
L
S
A
P
R
V
I
A
V
E
AHA
V
G
G
N
W
L
A
S
G
G
W
T
DGRHR
L
G
T
S
P
EKD
I
G
F
P
Y
H
S
T
W
A
R
GH
N
R
E
I
N
E
A
M
-
M
A
F
S
W
T
S
-
F
L
V
E
H
G
T
Y
A
E
W
I
D
R
G
R
P
S
P
Q
H
H
V
W
A
K
Y
L
Q
W
V
A
R
K
I
D
L
E
L
V
L
G
K
V
R
T
I
R
Q
G
W
S
V
E
V
A
G
A
------
T
T
E
L
E
A
D
G
L
M
I
T
G
P
-
G
Q
S
T
----
K
A
L
A
A
H
P
R
V
L
S
I
A
E
F
W
D
L
A
G
K
R
K
LPIS
S
R
A
A
V
I
G
G
G
E
-
T
A
G
-
S
A
L
D
E
L
V
R
H
EML
T
-
I
S
V
I
S
P
M
A
S
Y
F
E
N
S
L
F
S
D
PTKW
N
A
L
S
I
Q
E
R
R
D
V
I
R
R
T
D
R
G
V
F
S
V
R
V
Q
E
S
L
LG
D
N
R
V
H
H
L
Q
G
R
V
T
R
I
V
G
Q
G
D
G
V
A
V
T
L
R
N
E
M
--
R
A
D
Q
V
H
N
F
D
L
V
V
D
A
T
G
G
Q
---
P
L
W
F
L
D
L
FD
S
E
S
A
D
L
L
E
L
A
V
G
G
P
L
T
Q
------
Q
R
I
E
S
S
I
G
Y
D
L
A
------
V
T
G
L
---------------
G
A
K
L
Y
L
P
-------
N
M
A
A
L
A
QGPGF
P
N
L
S
C
L
G
E
L
S
D
R
V
L
R
-------
21
Fugue
63.98
13%
-44
- C4 -
2A1F
-
PYRH_HAEIN
A:
[1-239]
---------------------------
L
S
Q
P
-------------------------------------------------------
I
Y
K
R
I
L
L
K
-
L
S
G
E
A
L
Q
-------
G
E
D
G
L
G
I
D
P
-----
A
I
L
D
R
M
A
V
E
I
K
E
L
V
E
M
G
V
-------------------------------
E
V
S
V
V
L
----
G
G
G
N
L
F
R
G
A
K
L
A
K
A
G
M
N
R
V
V
G
D
H
----
M
G
M
L
A
T
V
M
N
G
L
A
M
R
-
D
S
L
F
R
A
D
V
N
-----
A
K
L
M
S
A
F
Q
L
N
G
I
C
D
T
Y
N
W
----
S
E
A
I
K
M
L
R
E
K
R
V
V
I
F
S
A
G
T
G
N
P
F
F
T
-----------
T
D
S
T
A
C
L
R
G
I
E
I
E
------
A
D
-----
V
V
L
K
A
T
K
V
D
G
V
Y
D
C
A
K
L
Y--
K
N
L
S
Y
A
-----
E
V
I
D
K
E
L
K
V
-
M
D
L
S
A
------
F
T
L
A
R
D
H
G
M
P
I
R
------
V
F
N
M
---------------------
G
-------
K
P
G
A
L
R
-----
Q
V
V
T
G
T
E
E
G
T
T
I
C
E
G
-------
18
Fugue
58.21
13%
39
- C4 -
4MZV
1
EPCAM_HUMAN
A:
[4-243]
----------------------------
E
E
C
V
C
E
N
Y
K
---
L
A
V
N
C
F
V
N
N
N
R
Q
-----
C
Q
C
T
S
---
V
G
A
Q
N
T
V
I
C
S
K
-----
L
A
A
K
C
L
V
M
K
A
E
M
Q
-
G
S
K
L
G
R
R
A
K
P
E
G
A
L
Q
N
N
D
G
L
Y
D
P
-----
D
-
C
----------
D
E
S
G
L
F
K
A
--
K
Q
C
Q
G
T
S
------
T
C
W
C
V
N
T
A
G
V
R
R
------
T
----
D
K
D
T
E
I
T
C
S
E
R
V
R
T
Y
W
I
I
I
E
L
K
H
----
K
A
R
E
K
P
Y
D
S
K
-
S
L
R
-
T
A
L
Q
K
E
I
T
T
-----
R
-----------
Y
Q
L
D
P
K
----
F
I
T
S
I
L
Y
E
N
N
V
I
T
I
D
L
V
Q
Q
S
S
Q
K
T
Q
-----
N
---
D
V
D
I
A
D
V
A
Y
Y
F
E
K
D
V
------
K
G
E
S
--
L
F
H
------------
S
K
K
---
M
D
L
T
V
N
--------------
G
E
Q
L
D
L
------------
D
P
G
Q
T
L
------
I
Y
Y
V
---------------
D
E
----
K
-------
A
P
E
F
S
M
-----
Q
G
L
K
H
-----------------
22
Fugue
50.94
8%
7
- C2 -
3OA2
3
WBPB_PSEAE
A:
[3-314]
---------------M
K
N
F
A
L
I
GAAGY
I
A
P
R
H
M
R
A
I
K
---
D
-
T
G
N
C
L
V
S
A
Y
D
-----
I
N
D
S
V
---
G
I
I
D
S
I
S
P
Q
S
E
--
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
-----
A
G
L
R
L
--------
G
C
D
V
I
C
E
K
--
P
L
V
P
T
P
E
------
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
----
L
------------------
Q
L
R
H
----
H
Q
A
I
I
A
L
K
D
K
-
V
A
R
-
E
S
P
H
K
Y
E
V
D
-----
L
T
Y
I
T
S
R
G
N
W
Y
L
K
S
W
K
G
D
----
P
R
K
S
F
G
---------
V
A
T
N
I
G
V
H
F
Y
-----
D
M
L
H
F
I
F
G
K
L
Q
R
N
V
V
H
F
T
S
------
E
Y
K
T
--
A
G
Y
L
E
Y
E
Q
-
A
R
V
R
W
F
L
S
V
---
D
A
N
D
L
P
-----
E
S
V
K
G
K
K
P
T
Y
R
S
I
T
V
NGEEME
F
D
L
H
T
T
S
Y
E
E
I
L
A
GRGYG
I
D
D
A
---------------
R
H
C
V
E
T
V
-------
N
T
I
R
S
A
-----
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
-------
3
PsiBlast_PDB
39.77
48%
-25
- C5 -
2WWY
-
RECQ1_HUMAN
A:
[207-239]
------------------------------------------------------------
T
A
---
T
A
T
N
H
V
L
T
D
A
Q
--
K
I
L
C
I
E
K
C
-
F
T
F
T
-
A
S
-
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
T
E
D
F
I
E
D
-----
I
V
K
L
I
N
G
R
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
--
K
D
S
E
Q
V
T
------
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
----
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
----
F
G
M
G
I
D
K
P
D
V
-
R
F
V
-
I
H
H
S
M
S
K
S
M
-----
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
----
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
G
Q
Q
-----
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
------
M
A
Q
H
--
F
D
E
V
W
N
S
E
A
C
N
K
M
C
D
N
C
C
---
K
D
S
A
F
E
-----
R
K
N
I
T
E
Y
C
R
D
L
I
K
I
L
------
K
Q
A
E
E
L
N
E
K
L
T
P
------
L
K
L
I
---------------
D
S
W
M
G
K
G
-------
A
A
K
L
R
V
-----
A
G
V
V
A
P
T
L
P
R
E
D
L
E
K
-------
2
PsiBlast_PDB
38.82
48%
-20
- C5 -
2V1X
1
RECQ1_HUMAN
A:
[207-239]
------------------------------------------------------------
T
A
---
T
A
T
N
H
V
L
T
D
A
Q
--
K
I
L
C
I
E
K
C
-
F
T
F
T
-
A
S
-
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
T
E
D
F
I
E
D
-----
I
V
K
L
I
N
G
R
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
--
K
D
S
E
Q
V
T
------
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
----
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
----
F
G
M
G
I
D
K
P
D
V
-
R
F
V
-
I
H
H
S
M
S
K
S
M
-----
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
----
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
G
Q
Q
-----
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
------
M
A
Q
H
--
F
D
E
V
W
A
C
N
K
M
C
D
N
C
C
K
D
S
---
A
F
E
R
K
N
-----
I
T
E
Y
C
R
D
L
I
K
I
L
K
Q
A
------
E
E
L
N
E
K
L
T
P
L
K
L
------
I
D
S
W
---------------
M
G
K
G
A
A
K
-------
L
R
V
A
G
V
-----
V
A
P
T
L
P
R
E
D
L
E
K
I
I
A
-------
1
PsiBlast_PDB
38.56
48%
-22
* C5 *
4U7D
-
RECQ1_HUMAN
A:
[207-239]
------------------------------------------------------------
T
A
---
T
A
T
N
H
V
L
T
D
A
Q
--
K
I
L
C
I
E
K
C
-
F
T
F
T
-
A
S
-
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
T
E
D
F
I
E
D
-----
I
V
K
L
I
N
G
R
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
--
K
D
S
E
Q
V
T
------
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
----
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
----
F
G
M
G
I
D
K
P
D
V
-
R
F
V
-
I
H
H
S
M
S
K
S
M
-----
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
----
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
G
Q
Q
-----
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
------
M
A
Q
H
--
F
D
E
V
W
A
C
N
K
M
C
D
N
C
C
K
D
S
---
A
F
E
R
K
N
-----
I
T
E
Y
C
R
D
L
I
K
I
L
K
Q
A
------
E
E
L
N
E
K
L
T
P
L
K
L
------
I
D
S
W
---------------
M
G
K
G
A
A
K
-------
L
R
V
A
G
V
-----
V
A
P
T
L
P
R
E
D
L
E
K
I
I
A
-------
4
PsiBlast_PDB
37.82
37%
-5
- C6 -
2AA4
-
NANK_ECOLI
A:
[69-108]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
S
L
L
A
L
N
------
P
H
N
L
--
G
G
L
L
H
F
P
L
V
K
T
L
E
Q
L
T
N
L
---
P
T
I
A
I
N
-----
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
G
------
D
I
T
D
M
V
F
I
T
V
S
T
------
G
V
G
G
---------------
G
V
V
S
G
C
K
-------
L
L
T
G
P
G
-----
G
L
A
G
H
I
G
H
T
L
A
D
P
H
G
-------
23
Fugue
34.66
18%
86
* C4 *
3E7K
-
TRPM7_RAT
A:
[2-55]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
G
S
R
V
T
F
E
R
V
E
Q
M
S
I
Q
I
K
E
V
G
D
R
V
----
N
Y
I
K
R
S
L
Q
S
L
-
D
S
Q
I
G
H
L
Q
D
L
S
A
L
-----
T
V
D
T
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
32.89
21%
221
- C4 -
3BXK
-
D:
[1-19]
--------------------------------------------------------------------------------------------------------------------
K
I
-----
Y
A
A
M
M
I
M
E
Y
Y
R
Q
S
K
A
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
29.84
16%
72
- C4 -
2L37
-
RIP1_LUFAE
A:
[1-43]
--------------------------------------------
G
S
P
R
T
E
Y
E
-----
A
C
R
V
R
---
C
Q
V
A
E
H
G
V
-
E
R
--
Q
R
R
C
Q
Q
V
C
E
K
R
L
R
E
R
E
-
G
R
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
28.87
20%
19
- C6 -
2QFA
2
BIRC5_HUMAN
A:
[43-91]
---------------------------------------------------------
F
I
H
C
P
---
T
-----
E
N
E
P
D
--
L
A
Q
C
F
-
F
C
F
K
E
L
--
E
G
-
W
E
P
D
D
D
---
P
I
----
E
E
H
K
K
H
S
------
S
G
C
A
F
L
S
V
K
K
Q
F
E
E
L
T
L
G
E
F
L
--
K
L
D
R
E
R
A
------
K
N
K
I
A
K
E
T
N
N
K
K
K
E
F
E
E
T
A
----
K
K
V
R
R
A
I
E
Q
L
A
A
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
21.70
25%
84
- C5 -
1PVZ
-
KA142_MESMA
A:
[1-31]
-------------------------------------------------------------------
T
P
F
A
I
K
C
A
T
--
D
A
D
C
S
R
K
C
P
---------
G
N
P
P
C
R
N
G
F
C
A
C
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
21.44
29%
231
* C6 *
3WWL
1
LYSW_THET8
A:
[2-15]
------------------------------------------------------------------------------
V
G
T
C
P
-
E
C
G
A
E
L
R
L
E
N
-
P
E
L
G
E
L
V
V
C
E
D
C
G
A
E
L
E
V
V
G
L
D
P
-----
L
R
L
E
P
A
P
E
E
A
E
D
W
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
19.55
13%
248
- C1 -
1VQ8
-
RL37A_HALMA
Z:
[23-37]
------------------------------------------------------------------------
E
M
N
E
--
D
H
A
C
P
-
N
C
G
E
D
R
V
D
R
Q
-
G
T
G
I
W
Q
C
S
Y
C
D
Y
K
F
T
G
G
S
Y
K
P
E
T
-----
P
G
G
K
T
V
R
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
16.09
20%
229
- C6 -
2JNY
-
?
A:
[8-22]
--------------------------------------------------------------------------
L
E
--
V
L
A
C
P
-
K
D
K
G
P
L
R
Y
L
E
-
S
E
Q
L
L
V
N
E
R
L
N
L
A
Y
R
I
D
D
G
I
P
V
L
-----
L
I
D
E
A
T
E
W
T
P
N
N
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
11.21
33%
468
- C3 -
2ZVK
-
?
U:
[8-19]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
Q
-
T
L
E
S
F
F
K
P
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------