@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0387: (2015-11-30 )
MVTVILAEKETQAAAYAESLGPASKKGKVHIIKHTPYFSDEVHVIAAEGHLFEYGLPKDNWDLDKLPLVDVSFKQTLKQDKVSKEIFKQIYQEVTAADQVIIGTDSDREGERIAYSILSHIPEGKNKVTKRLWVNSLTTRALQKAFQNLREPIETYNYYLEAEARAQSDWLVGMNLSPLVTLELQKRGRLPKGKGNSLSVGRVQTPGVRLICENDLAIQNFRPETYWKLQLQDKETEISFSNKEKYSDSELILAQARQLKAISIVSSVEMEEKQRAAPHLFNLSDIQGLAAKQWGFEPTKTERLIESLYLKKYLSYPRTDTRFITEEEFDYLKNYLKSYQEVINCSFEAVNLEPRENYVNPEKVAKTSHYALIPTENIPNLVTLKPDERLIYEAVVRRTLLMFAADCRYSTTTVEVENQGLVFKTTGRQMFDPGWAAFSQQKLKGDIELPDYRVGDQIETKVIIVEGMTKPPKRITESQLISDILPKYGLGTQATRATMLQTIQDRGYITKDKKTGQLFPTNKAYLLIHYLYDNEFASPETTGGWELFLSQIGEGEINPREFVDAIKEKLAAQIAVVKERSD
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20...-.....30.......-.40..---------....-..50.--.-------......------60----.-.-.-----......----70........80.----------...--....90........100.......110.......120--...--.--..-..130.......140.......150........160.......170.......180.......190.-.....-.200.......210.......220......------------.230---.------..----...-.-.240----------------..--......250........260.--------.......270.----......280.......290.......300.......--------310-------........320.......330......-.340.-...-....350-.........360.....-------..370....-..--.---380.-----------........390.......400.......410.......420.........430.----.-.......440..----.-.----..--.450.......-460..-.....-.470.......480..--.----------------...--------------.490.......500.......--510.......520.......530-..--.---....-.540.......550.......560.......570.......580--------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
T
V
I
L
AEKE
T
Q
A
A
A
Y
A
E
SLGPAS-KKG
K
V
H
I
I
K
HTPYF-SD
E
V
H
---------
V
I
A
A-EG
H
L
F
--E-------YGLPKD------N-----W-D-L-----DKLPLV----
D
V
S
F
K
Q
T
L
K
Q
D
K
V
----------
S
K
E
--
I
F
K
Q
I
Y
Q
E
VTAAD
Q
V
I
I
GTDSDRE
G
E
R
I
A
Y
S
I
L
S
HI---PEG--
K
--
N
K
-
V
T
K
R
L
W
V
N
S
L
T
T
R
A
L
Q
K
A
F
Q
N
L
R
E
-
P
I
E
T
Y
N
Y
Y
L
E
A
EARAQS
D
W
L
V
GMNLS
P
L
V
T
L
E
L
Q
KRGRLPKG-KGNSL-SVGRVQTP
G
V
R
L
I
CENDL
A
I
QNFRPE
T
Y
W
K
------------
L
Q
L----Q------DK----ETE-I-SFS-----------------NK--EKYSD
S
E
-
L
I
L
A
Q
A
RQ
L
K
-
A
I
--------
S
I
V
S
S
V
E
M
E
E
K
----
Q
RAAPHLF
N
L
S
D
I
Q
G
L
A
A
K
QWGFEP
T
K
T
E
R
L
I
E
S
L
Y
--------
L
K
--------
K
Y
LSYPRTD
T
R
FI
T
E
E
E
F
D
Y
L
K
N
Y
L
K
S
-
Y
Q
E
-
V
-INC-
S
F
E
A
V---NLEPRENYV
N
P
E
K
VAKT-------S
H
Y
A
L
I
PTE-NI--P---
N
--
L
-----------
V
T
LKPD
E
R
L
I
Y
E
A
V
V
R
R
T
L
L
M
F
AADCRYS
T
T
T
V
E
V
ENQ
G
--
L
V
F
K
TTGRQM--F----D-P
G
W
A
A
F
S
Q
Q
K
LK----G-D----IE--LPDYRVGDQ
I
E
-
T
-
K
V
I
-
I
VEGM-TKPP
K
R
I
T
E
S
Q
L
I
S
D
I
--
L
----------------
P
KY--------------GLG
T
Q
A
T
R
A
T
M
L
Q
T
I
Q
DRGYI--TKDKKTGQLFPTN
K
A
Y
L
L
I
H
Y
L--YD--N---EFAS-PETTG
G
W
E
L
F
L
S
QIGEGEI
N
P
R
E
F
V
D
A
I
K
E
K
L
A
A
Q
I
A
V
V
KERSD--------------------------------------------------
22
HHSearch
95.66
27%
-61
- C2 -
1I7D
3
TOP3_ECOLI
A:
[1-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
E
C
G
-----
N
G
Q
V
----------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
Q
L
Q
P
R
P
S
V
T
------------
K
--
Q
L
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
---
Q
L
A
--
P
E
K
R
Q
-
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
------
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
------
I
V
----
T
P
A
D
E
-
R
F
T
A
I
W
Q
P
S
EACEPYQDEEG
R
L
--
L
H
R
P
L
A
E
-
H
V
V
N
R
I
S
G
Q
P
-----------
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
--------
E
T
H-------
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
-
I
S
V
-
H
-
A
-
P
-
D
L
L
P
Q
PVV
D
P
D
I
R
N
R
C
W
D
D
K
K
V
--
D
-------
A
H
H
A
I
I
P
T
A
-
R
S
--
S
---
A
--------------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
DEEN
D
-
G
----
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
--
T
G
IARFVQD
K
D
L
K
K
I
L
R
A
T
D
--------------
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
K
K
G
R
--
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
--
P
E
------
M
A
T
R
-
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
3
PsiBlast_PDB
93.32
27%
-62
- C2 -
2O54
3
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
ENDG
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
5
PsiBlast_PDB
93.24
27%
-58
- C2 -
2O5C
3
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
ENDG
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
LRATD
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
2
PsiBlast_PDB
93.08
27%
-59
- C2 -
2O19
3
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
ENDG
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
7
PsiBlast_PDB
93.07
27%
-62
- C2 -
1I7D
3
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
ENDG
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
4
PsiBlast_PDB
92.81
27%
-63
- C2 -
2O59
2
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
-C-
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
---------NDG-
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
1
PsiBlast_PDB
92.68
27%
-63
- C2 -
1D6M
-
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
--------
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
I
V
T
PAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
ENDG
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
LRATD
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
----------------------------------------------------
6
PsiBlast_PDB
92.37
27%
-59
- C2 -
2O5E
3
TOP3_ECOLI
A:
[3-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P
K
P
H
-
R
K
G
D
G
F
I
-----
E
C
-
G
N
G
Q
V
---------
V
T
W
C
-
I
G
H
L
L
--
E
-------
Q
A
Q
P
D
A
YDSRYA
R
-----
W
-
N
-
L
-----
A
D
L
P
I
V
----
P
E
K
W
-
Q
L
Q
P
R
P
S
V
----------
T
K
Q
L
N
V
I
K
R
F
L
H
E
---
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
QLA
P
E
K
--
R
--
Q
Q
-
V
-
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
-
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
----
L
G
R
-
N
A
G
-
Y
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
------------
V
K
A
----
H
IVTPAD
E
R
----
F
T
A
-
I
-
W
Q
P
-----------------
S
E
AC
E
P
Y
Q
D
E
E
-
G
R
L
L
H
R
P
L
A
E
-
H
V
V
N
R
I
SG
Q
P
A
I
V
T
S
Y
N
D
K
R
E
----
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E-------
T
H
--------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
-------
A
G
-
R
H
A
-
V
-
M
N
A
I
S
V
H
A
P
---
D
L
L
P
-
Q
P
V
V
D
P
D
I
R
N
R
C
WDDKKVD
A
H
H
A
I
I
P
T
A
-
R
---
S
---
S
--
A
-----------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
----
E
-
A
G
W
R
T
L
L
G
S
K
E
R
----
D
-
E
END
G
T
P
--
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
E
-
V
V
E
R
Q
-
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
----------------
A
R
F
VQD
K
D
L
K
K
I
LRATD
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
--
T
--
K
K
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
------
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
V
--------------------------------------------------
47
Fugue
86.49
23%
-57
- C2 -
4CGY
1
TOP3A_HUMAN
A:
[22-640]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FS
R
A
A
M
E
M
A
L
RGV
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
G
R
-
M
R
R
R
E
G
L
S
K
F
N
K
I
Y
-
E
F
D
Y
H
L
YG
Q
N
V
T
M
V
M
T
S
V
-
S
G
H
L
L
--
A
-------
H
D
F
Q
M
Q
------
F
RK---
W
-
Q
S
C
-----
N
P
L
V
L
F
----
E
A
E
I
E
K
Y
C
P
E
N
F
V
------------
D
--
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
---
K
A
V
--
K
--
P
N
L
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
-
P
--
D
Q
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
I
--
F
P
E
V
L
A
E
Q
L
I
-
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
------------
I
K
V
----
T
------
H
D
H
KD
G
I
V
E
-
F
-
N
W
K
-----------------
R
H
--
R
L
F
N
H
T
A
-
C
L
V
L
Y
Q
L
C
V
E
D
P
M
--------
A
T
V
V
E
V
R
S
K
P
K
----
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
--------
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
--
L
T
V
L
V
E
Q
-
Q
T
P
-
D
-
P
R
W
-
G
A
F
A
Q
---
S
I
L
E
R
G
G
P
-
T
P
R
N
G
N
K
S
DQ-----
A
H
P
P
I
H
P
T
K
-
Y
T
--
N
---
N
--
L
--------------
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
A
Q
--
E
R
F
V
A
H
G
L
M
I
--
L
----
A
-
R
N
Y
L
D
V
Y
P
Y
D
H
W
----
S
-
D
----
K
I
--
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
-
T
V
E
-
M
V
D
G
E
-
T
S
P
P
K
L
L
T
E
A
D
L
I
A
-
L
--
M
----------------
E
K
H
--------------
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
--
G
L
T
P
D
K
-
R
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
S
M
G
--
Y
---
E
M
S
K
-
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
K
L
D
E
A
L
A
Q
Y
FGNGT------------------------------------
46
Fugue
83.35
24%
-56
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
--------------------
N
E
Y
E
---------
V
F
A
S
-
M
G
H
I
I
--
D
---------
L
P
K
S
------
K
-----
F
-
G
-
V
-----
D
L
--------
E
K
D
F
E
P
E
F
A
V
I
K
G
----------
K
E
K
--
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
-----
N
--
T
--
L
G
-
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
-
I
--
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
-----------
N
L
-
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
------------
I
T
V
----
N
------
F
D
----
G
L
T
-
A
-
E
I
D
-----------------
V
K
--
E
K
K
F
F
D
A
-
E
T
L
K
E
I
Q
S
I
D
-
E
L
--------
V
-
V
E
E
K
K
V
S
V
K
----
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
I
--------
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
-
E
-
Y
V
G
-
A
H
E
A
I
---
R
--
P
T
N
V
F
M
T
P
E
E
A
G
K
Y
------------------------------------------
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
GK
Y
R
F
K
G
T
V
L
K
K
--
I
----
F
-
D
G
Y
E
K
V
W
K
T
E
R
N
----
T
-------
G
--
E
F
P
F
E
E
G
E
S
V
K
-
P
-
V
V
V
-
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
---
M
----------------
E
R
L
--------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
--
K
K
I
R
--
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
--
E
K
KY
S
---
D
V
V
S
-
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
NQKCSCG
K
E
M
R
L
S
F
G
KY
G
F
Y
L
K
C
E
C
G
K
T
R
S
V
K
NDE
I
A
V
I
D
DGKIFL
20
PsiBlast_PDB
82.58
24%
-44
- C2 -
4CGY
1
TOP3A_HUMAN
A:
[37-600]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
G
R
-
M
R
R
R
E
G
L
S
K
F
N
K
I
Y
-
E
F
D
Y
H
L
YG
Q
N
V
T
M
V
M
T
S
V
-
S
G
H
L
L
A
H
D
-------
F
Q
M
Q
F
R
------
K
-----
W
Q
S
-
C
-----
N
P
L
V
L
F
----
E
A
E
I
E
K
Y
C
P
E
N
F
V
------------
D
--
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
-
H
V
---
C
K
A
V
K
P
--
N
L
-
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
-
P
D
Q
R
V
S
D
A
V
D
V
--
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
I
--
F
P
E
V
-
L
A
E
Q
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
------------
I
K
V
T
H
D
H
K
------
D
G
----
I
V
E
-
F
-
N
W
K
-----------------
R
H
--
R
L
F
N
H
T
A
C
L
V
L
Y
Q
L
C
V
E
D
-
P
M
--------
A
T
V
V
E
V
R
S
K
P
K
----
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
--------
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
----
L
N
L
T
V
L
V
-
E
Q
Q
-
T
-
P
D
P
-
R
W
G
A
F
---
A
Q
S
I
L
E
R
G
G
P
T
P
R
N
G
N
K
-------
S
D
Q
A
H
P
P
I
H
-
P
T
--
K
---
Y
--
T
-----------
N
N
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
A
Q
--
E
R
F
V
A
H
G
L
M
I
--
L
----
A
-
R
N
Y
L
D
V
Y
P
Y
D
H
W
----
S
-
D
----
K
I
--
L
P
V
Y
E
Q
G
S
H
F
Q
-
P
-
S
T
V
E
M
V
D
G
E
-
T
S
P
P
K
L
L
T
E
A
D
L
I
A
-
L
--
M
----------------
E
K
H
--------------
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
---
F
L
P
G
H
L
G
M
G
L
V
E
G
---
Y
D
--
S
MGY
E
M
S
K
-
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
--------------------------------------------------
19
PsiBlast_PDB
82.48
24%
-43
- C2 -
4CHT
1
TOP3A_HUMAN
A:
[38-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
G
R
-
M
R
R
R
E
G
L
S
K
F
N
K
I
Y
-
E
F
D
Y
H
L
YG
Q
N
V
T
M
V
M
T
S
V
-
S
G
H
L
L
A
H
D
-------
F
Q
M
Q
F
R
------
K
-----
W
Q
S
-
C
-----
N
P
L
V
L
F
----
E
A
E
I
E
K
Y
C
P
E
N
F
V
------------
D
--
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
-
H
V
---
C
K
A
V
K
P
--
N
L
-
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
-
P
D
Q
R
V
S
D
A
V
D
V
--
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
I
--
F
P
E
V
-
L
A
E
Q
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
------------
I
K
V
T
H
D
H
K
------
D
G
----
I
V
E
-
F
-
N
W
K
-----------------
R
H
--
R
L
F
N
H
T
A
C
L
V
L
Y
Q
L
C
V
E
D
-
P
M
--------
A
T
V
V
E
V
R
S
K
P
K
----
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
--------
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
----
L
N
L
T
V
L
V
-
E
Q
Q
-
T
-
P
D
P
-
R
W
G
A
F
---
A
Q
S
I
L
E
R
G
G
P
T
P
R
N
G
N
K
-------
S
D
Q
A
H
P
P
I
H
-
P
T
--
K
---
Y
--
T
-----------
N
N
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
A
Q
--
E
R
F
V
A
H
G
L
M
I
--
L
----
A
-
R
N
Y
L
D
V
Y
P
Y
D
H
W
----
S
-
D
----
K
I
--
L
P
V
Y
E
Q
G
S
H
F
Q
-
P
-
S
T
V
E
M
V
D
G
E
-
T
S
P
P
K
L
L
T
E
A
D
L
I
A
-
L
--
M
----------------
E
K
H
--------------
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
---
F
L
P
G
H
L
G
M
G
L
V
E
G
---
Y
D
--
S
MGY
E
M
S
K
-
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
--------------------------------------------------
23
HHSearch
81.54
23%
-54
- C2 -
1MW9
9
TOP1_ECOLI
X:
[2-582]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
-------------------
Y
V
----------
V
K
S
S
-
V
G
H
I
R
--
D
-------
L
P
T
----------ERGAL
V
-
N
R
M
-----
G
V
D
P
W
H
----
N
W
E
A
H
Y
E
V
L
P
G
K
E
------------
K
--
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
---
G
G
D
-----
D
A
-
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
--
P
-
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-----------
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
------------
V
D
A
----
S
------
T
T
----
T
P
S
-
G
E
A
L
A
LQVTHQNDKPF------
R
P
--
V
N
K
E
Q
T
Q
-
A
A
V
S
L
L
E
K
A
R
-----------
Y
S
V
L
E
R
E
D
K
P
T
----
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
--------
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
-
N
F
G
K
K
-
Y
-----
L
P
-----
E
S
P
N
Q
Y
A
-----------------
R
E
A
I
R
P
S
D
-
V
N
--
V
MAE
S
--
L
-----------
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
----
F
-
D
G
W
T
K
V
M
P
A
L
-------E
D
----
R
I
--
L
P
A
V
N
K
G
D
A
L
T
-
L
V
E
L
T
-
P
A
Q
H
F
-
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
--
E
-----------------
K
R
--------------
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
--
R
V
E
N
R
--
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
--
E
E
--
N
FR-
E
L
M
N
-
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
--------------------------------------------------
24
HHSearch
77.94
22%
-56
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
N
E
-------------------
Y
E
----------
V
F
A
S
-
M
G
H
I
I
--
D
-------
L
P
K
S
K
-------------
F
-
G
-
V
-----
D
L
E
K
D
F
----
E
P
E
F
--
A
V
I
K
G
K
E
------------
K
--
V
V
E
K
L
K
D
L
A
K
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
---
N
T
------
L
G
-
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
---
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-----------
K
S
N
L
-
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
------------
I
T
V
----
N
------
F
D
----
G
L
T
-
A
-
E
I
D
VK
E
K
-------------
K
F
--
F
D
A
E
T
L
K
-
E
I
Q
S
---
I
D
E
-----------
L
V
V
E
E
K
K
V
S
V
K
----
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
--------
E
G
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
-
V
F
G
-
E
E
Y
-----
V
G
----------------------------
A
H
E
A
I
R
P
T
N
-
V
F
--
M
---
T
--
P
EEAG-------
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
K
K
I
----
F
-
D
G
Y
E
K
V
W
K
T
E
R
N
-----------
T
G
--
E
F
P
F
E
E
G
E
S
V
K
-
P
V
V
V
K
-
I
E
E
Q
E
-
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
--
E
-----------------
R
L
--------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
--
K
K
I
R
G
--
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
--
E
K
--
K
YS-
D
V
V
S
-
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
--------------------------------------------------
49
Fugue
76.41
20%
-41
- C2 -
4DDU
3
RGYR_THEMA
A:
[2-1103]
AVN
S
K
Y
H
HSCINCGGLNT
D
E
R
N
E
R
GLPCEVCLPEDSPSD
I
Y
R
A
L
L
E
R
KTLKE
Y
R
F
Y
H
E
F
W
N
E
Y
E
D
F
R
S
F
F
K
K
K
F
G
K
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
K
S
F
T
MVAPTGVG
K
T
T
F
G
M
M
T
A
L
W
L
A
R
K
G
K
K
S
A
L
V
F
PT
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
ADEK
V
K
I
F
G
F
Y
SSMK
K
E
E
K
E
K
F
E
K
S
F
E
EDDYH
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
K
L
S
Q
KRFD
F
V
F
V
DD
V
D
A
V
L
KA
S
R
N
I
D
T
L
L
M
M
VGIP
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
PKN
L
K
P
G
I
L
V
V
S
S
ATAKPRGIRP
L
L
F
R
D
L
LNFTVGRLVSVARN
I
T
H
V
R
I
SSRS
K
E
K
L
V
E
L
L
E
I
F
RDG
I
L
I
F
A
QT
E
E
E
G
K
E
L
Y
E
Y
L
K
R
F
KFNVGETWSEF
E
K
N
F
E
D
F
K
V
GKIN
I
L
I
G
V
Q
A
Y
Y
G
K
L
TRGVDLPERIK
Y
V
I
F
WG
T
P
S
M
R
F
S
LELDKAP
R
F
V
L
A
R
V
L
K
E
M
GLIK
A
Q
E
N
P
D
V
E
E
L
R
K
I
A
KEHLT
Q
K
E
F
V
E
K
V
K
E
M
FRGVVVKDEDL
E
L
I
I
P
D
V
Y
T
Y
I
Q
A
S
G
RSSRILNGVL
V
K
G
V
S
V
I
F
E
ED
E
E
I
F
E
S
L
K
T
R
L
L
L
IAE
E
E
I
I
E
EAEAN
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
E
L
T
D
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
G
R
A
S
-
S
R
K
E
R
N
I
I
V
H
E
A
V
T
-
G
E
G
V
I
---------
L
F
T
A
T
R
G
H
V
Y
--
D
LVTKGGI
H
G
V
E
E
E
------
N
-----
G
-
K
-
F
V
P
V
Y
N
S
L
K
R
C
R
----
D
C
G
Y
Q
F
T
E
D
R
D
E
C
PVCSSKNIDD
K
T
E
--
T
L
R
A
L
R
E
I
S
L
E
A
D
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
---
L
P
S
--
T
--
R
S
-
L
-
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
S
V
R
--
F
V
D
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
-
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
----------
S
N
L
-
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
Y
K
K
S
-
E
K
D
F
T
L
------------
L
V
L
----
E
------
N
G
--------
V
-
N
L
E
-----------------
V
E
--
G
K
I
A
D
D
-------------
V
V
--------
T
V
V
E
L
Q
E
A
E
E
E
----
K
N
P
L
P
-
P
Y
T
T
S
S
A
L
S
E
I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
--------
E
K
--------
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
E
G
Q
N
V
A
R
T
Y
L
R
K
-
I
G
K
-
E
-
D
I
F
-
M
G
R
S
W
---
S
T
E
G
A
H
E
A
I
R
P
V
K
P
I
D
A
-------
R
E
L
E
E
M
I
E
E
-
G
L
--
I
---
A
---------------
D
L
T
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
S
Q
S
A
A
V
K
V
K
K
Q
I
V
T
V
D
V
D
G
--
K
R
M
G
I
E
Q
I
V
E
--
I
----
L
R
D
G
W
N
L
F
V
P
L
T
V
S
----
P
-
R
----
F
E
--
H
R
T
Y
K
I
K
E
K
K
F
-
Y
-
K
---------
K
H
T
V
P
L
F
T
Q
A
S
I
V
E
E
M
--
K
----------------
K
R
---------------
G
I
G
R
P
S
T
Y
A
K
I
V
E
V
L
F
R
R
G
Y
V
--
Y
E
D
K
Y
-
K
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
--
K
E
RY
E
---
K
Y
V
T
-
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
G
E
E
D
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
--------------------------------------------------------
25
HHSearch
75.32
19%
-52
* C2 *
1GKU
-
RGYR_ARCFU
B:
[506-1054]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
F
I
V
E
S
P
T
K
A
R
Q
I
S
R
F
F
G
K
P
S
V
K
V
L
D
G
A
V
V
Y
E
I
P
M
Q
K
Y
V
L
M
----------
V
T
A
S
-
I
G
H
V
V
--
D
-------
L
I
T
N
R
G
FHGV--
L
-----
V
-
N
-
G
-----
R
F
V
P
V
Y
ASIK---------
D
N
S
R
------------
S
--
R
I
E
A
L
R
K
L
A
H
D
A
E
F
V
I
V
G
T
D
P
D
T
E
G
E
K
I
A
W
D
L
K
N
L
L
---
S
G
------
C
G
-
A
V
K
R
A
E
F
H
E
V
T
R
R
A
I
L
E
A
L
E
S
L
R
D
---
V
D
E
N
L
V
K
A
Q
V
V
R
R
I
E
D
R
W
I
G
F
V
L
S
Q
K
L
W
E
R
F
N
----------
N
R
N
L
-
S
A
G
R
A
Q
T
L
V
L
G
W
I
I
D
R
F
Q
E
S
R
E
R
R
K
I
A
I
V
R
--------------------------------------
D
F
D
-----------------
L
V
--
L
E
H
D
E
---
E
------
E
F
D
-----------
L
T
I
K
L
V
E
E
R
E
E
----
L
R
T
P
L
P
P
Y
T
T
E
T
M
L
S
D
A
N
R
I
L
K
F
S
V
K
Q
T
M
Q
I
A
Q
E
L
F
--------
E
N
--------
G
L
I
T
Y
H
R
T
D
S
T
R
V
S
D
V
G
Q
R
I
A
K
E
Y
L
G
D
-----
D
-
F
---------------
V
G
R
E
W
G
E
--
S
--
G
-------
A
H
E
C
I
R
P
T
R
-
P
L
--
T
---
R
DD
V
QRLIQEGVLVV
E
G
L
R
W
E
H
F
A
L
Y
D
L
I
F
R
R
F
M
A
S
Q
C
R
P
F
K
V
V
V
K
K
Y
S
I
E
F
D
G
--
K
T
A
E
E
E
R
I
V
R
--
A
EGRA
Y
-
E
L
Y
R
A
V
W
V
K
--------------
N
E
--
L
P
---
T
G
T
-
F
R
----
V
K
-
A
E
V
K
S
-
V
P
K
V
L
P
F
T
Q
S
E
I
I
Q
M
M
--
K
-----------------
E
R
--------------
G
I
G
R
P
S
T
Y
A
T
I
V
D
R
L
F
M
R
N
Y
V
--
V
E
K
Y
G
--
R
M
I
P
T
K
L
G
I
D
V
F
R
F
L
--
V
R
--
R
YA-
K
F
V
S
-
E
D
R
T
R
D
L
E
S
R
M
D
A
I
E
R
G
E
L
D
Y
L
K
A
L
E
D
M
Y
A
E
I
K
S
I
D
----------------------------------------------------------
13
PsiBlast_PDB
73.70
28%
-49
- C2 -
1CY4
3
TOP1_ECOLI
A:
[92-512]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
---
I
G
G
--
D
--
D
A
-
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
---
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
----------
L
W
K
K
-
I
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
PSG
E
A
L
A
L
----
Q
V
-----
T
H
----
Q
N
D
-
K
-
P
F
R
P
V---------------
N
K
--
E
Q
T
Q
A
A
V
-
S
L
L
E
K
A
R
----------------
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
--
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
--------
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
----------
I
S
D
-
N
F
G
K
K
---
Y
L
P
E
S
P
N
Q
Y
A
---------------
H
E
A
I
R
P
S
D
V
N
V
MA
E
---
S
--
L
-----------
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
----
F
-
D
G
W
T
K
V
M
P
A
L
---------------I-
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
T
-
P
A
Q
H
F
-
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
---
L
----------------
E
K
R
--------------
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
--
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
--
N
F
--
R
---
E
L
M
N
-
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
--------------------------------------------------
14
PsiBlast_PDB
73.60
28%
-47
- C2 -
1ECL
-
TOP1_ECOLI
A:
[90-510]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
---
I
G
G
--
D
--
D
A
-
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
---
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
----------
L
W
K
K
-
I
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
PSG
E
A
L
A
L
----
Q
V
-----
T
H
----
Q
N
D
-
K
-
P
F
R
P
V---------------
N
K
--
E
Q
T
Q
A
A
V
-
S
L
L
E
K
A
R
----------------
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
--
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
--------
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
----------
I
S
D
-
N
F
G
K
K
---
Y
L
P
E
S
P
N
Q
Y
A
---------------
H
E
A
I
R
P
S
D
V
N
V
MA
E
---
S
--
L
-----------
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
----
F
-
D
G
W
T
K
V
M
P
A
L
R
--------------I-
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
T
-
P
A
Q
H
F
-
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
---
L
----------------
E
K
R
--------------
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
--
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
--
N
F
--
R
---
E
L
M
N
-
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
--------------------------------------------------
12
PsiBlast_PDB
73.52
28%
-45
- C2 -
1CY0
-
TOP1_ECOLI
A:
[92-512]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
---
I
G
G
--
D
--
D
A
-
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
---
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
----------
L
W
K
K
-
I
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
PSG
E
A
L
A
L
----
Q
V
-----
T
H
----
Q
N
D
-
K
-
P
F
R
PV---------------
N
K
--
E
Q
T
Q
A
A
V
-
S
L
L
E
K
A
R
----------------
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
--
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
--------
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
----------
I
S
D
-
N
F
G
K
K
---
Y
L
P
E
S
P
N
Q
Y
A
S
K
E
N
S
Q
E
-------
A
H
E
A
I
R
P
S
D
V
N
V
MA
E
---
S
--
L
-----------
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
----
F
-
D
G
W
T
K
V
M
------------------I-
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
T
-
P
A
Q
H
F
-
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
---
L
----------------
E
K
R
--------------
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
--
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
--
N
F
--
R
---
E
L
M
N
-
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
-------------------------------------------------------------
11
PsiBlast_PDB
73.32
28%
-47
- C2 -
1CY8
3
TOP1_ECOLI
A:
[92-512]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
---
I
G
G
--
D
--
D
A
-
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
---
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
----------
L
W
K
K
-
I
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
PSG
E
A
L
A
L
----
Q
V
-----
T
H
----
Q
N
D
-
K
-
P
F
R
P
V---------------
N
K
--
E
Q
T
Q
A
A
V
-
S
L
L
E
K
A
R
----------------
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
--
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
--------
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
----------
I
S
D
-
N
F
G
K
K
---
Y
L
P
E
S
P
N
Q
Y
A
---------------
H
E
A
I
R
P
S
D
V
N
V
MA
E
---
S
--
L
-----------
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
----
F
-
D
G
W
T
K
V
M
P
A
L
R
K
----
G
-
D
----
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
T
-
P
A
Q
H
F
-
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
---
L
----------------
E
K
R
--------------
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
--
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
--
N
F
--
R
---
E
L
M
N
-
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
--------------------------------------------------