@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0388: (2015-11-30 )
MEDELKTPYLDQYTDNLTAKVTKKSDDYQVYGRNKEVQSVIISLLRRTKNNPILVGEAGVGKSAIVEGITLAILRGQVPEPLKGLTVRSLELSSLMSEDDEGFIAKFKKIIEEMVATRGHNLLFVDEFHTIIGAGSQNGQALDAGNVIKPVLARGDIQLIGATTLDEFHEYIETDRALERRMQPVMVEEPTISQAITIIEQAKVIYEKFHGIQISSDAVHQAIRLSVRYLTDRFLPDKAFDLIDEAATIASVEGKSKVTEKDIAQVLKDKTGIPVTTILKGDQERLEGFKERLMNRVKGQEDAIEAVVDAVTIAQAGLQNEKRPLASFLFLGPTGVGKTELAKAIAEALFDDEAAMIRFDMSEYKQKEDVTKLIGNRATRIKGQLTEGVKQKPYCVLLLDEIEKAHSEVMDLFLQVLDDGRLTDSSGRLISFKNTIVIMTTNIGAKKIINKWELKGNFKDLTDRDRKQFEKSMDSELQNEFRPEFLNRIENKLIFNLLERDVIEKIAEKNLSEIADRMKRQNLTLSYEPSLIQYLSDVGTDVKNGARPLERLMKRKVLAPISVKSLQLDKSKQGYNVHLWVEGRAPDGNHRQEQRQIHMEIEGERDNFFS
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------.....----------------....10........20........30........40........50........60........70........80........90........100-........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240....----------------------------...250..-------------------------------------------------------------------------------------------------------------------------..---------------------------------------------------------.----..260.......270--------------------------.........280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380---........390.......400.......410.......420.......430.......440.......450.......460.......470...--....480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------MEDEL----------------KTP
Y
L
D
Q
YTDNL
T
A
K
VTKKSDD
Y
Q
V
YGRN
K
E
V
Q
S
V
I
I
S
L
L
R
RTKNN
P
I
L
V
GEAGV
G
K
S
A
I
V
E
G
I
T
L
A
I
LRGQVPEPLKG
L
T
V
R
S
L
E
L
S
S
L
MSEDD
E
--
G
F
I
A
K
F
K
K
I
I
E
E
M
V
A
TRGH
N
L
L
F
V
DEF
H
T
I
IGAGSQNGQALDAG
N
V
I
K
P
V
LARG
D
I
Q
L
I
G
AT
T
L
D
E
F
H
E
Y
I
E
T
D
R
A
L
E
RRMQ
P
V
M
VEEP
T
I
S
Q
A
I
T
I
I
E
Q
A
K
V
I
Y
E
KFH
G
I
Q
I
S
S
D
A
V
H
Q
A
I
R
L
S
V
R
Y
L
T
DRFL
P
D
K
A
F
D
L
I
D
E
A
----------------------------
A
T
I
ASVEG-------------------------------------------------------------------------------------------------------------------------KS---------------------------------------------------------K----V
T
E
K
D
I
A
Q
V
L
KDK----------------------------TGI
P
V
T
TILKG
D
Q
E
R
L
E
G
F
K
E
R
L
M
N
R
VKG
Q
E
D
A
I
E
A
V
V
D
A
V
T
I
A
Q
AGLQNEKRP
L
A
S
F
L
F
LGPTGV
G
K
T
E
L
A
K
A
I
A
E
A
LFDDE
A
A
M
I
R
F
D
M
S
E
Y
K
Q
K
E
D
V
T
K
L
I
GNR
A
T
R
I
----
K
G
Q
L
TEGVKQK
P
Y
C
V
L
L
L
D
E
I
E
K
A
H
S
E
V
M
D
L
F
L
Q
V
LDDGRLTDSS
G
R
L
I
S
FK
N
T
I
V
I
M
TTNI
G
A
K
K
I
I
N
K
W
ELKGNFKDL
T
D
R
D
R
K
Q
F
E
K
S
M
D
S
--
E
L
Q
N
EF
R
P
E
F
L
N
R
I
E
N
K
L
I
F
N
L
L
E
R
D
V
I
E
K
I
A
E
K
N
L
S
E
I
A
D
R
M
K
RQN
L
T
L
SY
E
P
S
L
I
Q
Y
L
S
D
VGTDVKN
G
A
R
P
L
E
R
L
M
K
R
KVLAP
I
S
V
K
S
L
QLDKSKQG
Y
N
V
H
L
W
V
E
GRAPDGN
H
R
Q
E
Q
R
Q
I
H
M
E
I
EGERDNFFS--
123
Fugue
90.28
46%
-90
- C4 -
1QVR
7
CLPB_THET8
A:
[4-850]
ERWT
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
KHQAID
L
P
H
L
W
A
V
L
L
KDERS
L
A
W
R
L
L
E
K
A
GAD
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
K
V
EGAEVGQYLT
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
KDRYVA
V
D
T
L
V
L
A
L
A
E
A
T
PGLPG
L
E
A
L
K
G
A
L
K
ELRGGRTVQTEHAES
T
Y
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
-
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
---------
Q
M
--
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
S
Q
G
E
V
I
L
F
I
D
E
--------------------
L
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
----------------------------
A
A
R
L
R
M
A
L
E
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
EKD
P
D
S
Q
E
RL
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
YDLN
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
S
E
K
L
RGARFV
R
L
---------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
--------
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
--
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
---------------
G
E
V
K
E
G
D
------
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
PA
135
HHSearch
86.59
45%
-88
- C4 -
3PXI
-
CLPC_BACSU
A:
[159-802]
-------------------------------------------------------------------------------------------------------------------------------------------------
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
-
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
-
G
N
I
I
L
F
I
D
A
---------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
----------------------------
G
S
K
V
R
L
R
S
-------------------------------------------------------------------------------------------------------------------------
F
T
PNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQE-----
V
T
V
D
D
I
A
M
V
V
S
S
W
----------------------------
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
----------
S
-------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
----------------------
V
M
G
--
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
-
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
T
A
--------------------
5
PsiBlast_PDB
83.02
39%
-89
- C4 -
3PXI
-
CLPC_BACSU
A:
[160-773]
--------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
-
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
-
I
R
Q
A
G
N
I
I
L
F
I
D
-------------
A
--------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
GSKVRLRSFTPNLKELEQKLDEVRKEKD
A
A
V
Q
S
Q
E
F
-------------------------------------------------------------------------------------------------------------------------
E
K
---------------------------------------------------------
A
----
A
S
L
R
D
T
E
Q
R
L
R
E
Q
VEDTKKSWKEKQGQEVTVDDIAMVVSSW
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
----------------
S
E
K
D
K
------
V
M
G
--
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
T
A
---------------------
7
PsiBlast_PDB
81.63
38%
-87
- C4 -
1R6B
5
CLPA_ECOLI
X:
[169-717]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
F
T
T
N
L
N
-
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
RG
D
F
E
K
R
F
K
A
L
L
K
Q
L
-
E
Q
D
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
----------------------------
G
A
R
A
R
L
M
P
-------------------------------------------------------------------------------------------------------------------------
V
S
---------------------------------------------------------
K
RKKT
V
N
V
A
D
I
E
S
V
V
A
R
I
----------------------------
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
G
I
E
---
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
GFDQ
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
----------------------------
A
ME
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
V
A
L
D
K
E
K
N
E
L
T
Y
G
F
Q
S
A
Q
K
----------------
6
PsiBlast_PDB
80.99
38%
-89
- C4 -
1KSF
7
CLPA_ECOLI
X:
[169-717]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
F
T
T
N
L
N
-
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
RG
D
F
E
K
R
F
K
A
L
L
K
Q
L
-
E
Q
D
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
----------------------------
G
A
R
A
R
L
M
P
-------------------------------------------------------------------------------------------------------------------------
V
S
---------------------------------------------------------
K
RKKT
V
N
V
A
D
I
E
S
V
V
A
R
I
----------------------------
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
G
I
E
---
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
GFDQ
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
------------------------
N
S
T
D
A
ME
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
V
A
L
D
K
E
K
N
E
L
T
Y
G
F
Q
S
A
Q
K
H
K
A
E
------------
20
PsiBlast_PDB
67.41
39%
-90
- C6 -
4CIU
1
CLPB_ECOLI
A:
[372-688]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
----------------------------
A
T
--
Q
L
E
G
-------------------------------------------------------------------------------------------------------------------------
K
T
MRLLRN---------------------------------------------------
K
----
V
T
D
A
E
I
A
E
V
L
A
R
W
----------------------------
T
G
I
P
V
S
R
M
M
E
S
E
R
E
K
L
L
R
M
E
Q
E
L
H
H
R
V
I
G
Q
N
E
A
V
D
A
V
S
N
A
I
R
R
S
R
A
G
L
A
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
C
K
A
L
A
N
F
M
F
D
S
D
E
A
M
V
R
I
D
M
S
E
F
M
E
K
H
S
V
S
R
L
V
G
A
---------
G
G
Y
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
L
D
A
V
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
D
D
G
R
L
T
D
G
Q
G
R
T
V
D
F
R
N
T
V
V
I
M
T
S
N
L
G
S
D
L
I
Q
E
R
------
F
--
L
---
D
Y
A
H
M
K
E
L
V
L
G
--
V
V
S
H
N
F
R
P
E
F
I
N
R
I
D
E
V
V
V
F
H
P
L
G
E
Q
H
I
A
S
I
A
Q
I
Q
L
K
R
L
Y
K
R
L
E
E
R
G
Y
E
I
H
I
S
D
E
A
L
K
L
L
S
E
N
G
Y
D
P
V
Y
G
A
R
P
L
K
R
A
I
Q
Q
Q
I
E
N
P
L
A
Q
Q
I
L
S
G
E
L
V
P
G
K
V
I
R
L
E
V
N
E
D
R
I
V
A
V
Q
H
----------------------
21
PsiBlast_CBE
64.86
44%
-83
- C6 -
1QVR
9
CLPB_THET8
C:
[520-825]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
---------------------
9
PsiBlast_PDB
64.69
44%
-87
- C6 -
4LJ5
1
A:
[5-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
22
PsiBlast_CBE
64.59
44%
-82
- C6 -
1QVR
3
CLPB_THET8
B:
[520-825]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
---------------------
10
PsiBlast_PDB
64.38
44%
-83
- C6 -
1QVR
3
CLPB_THET8
A:
[520-825]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
---------------------
8
PsiBlast_PDB
64.36
44%
-86
- C6 -
4LJ4
1
A:
[5-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
-
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
11
PsiBlast_PDB
63.37
44%
-88
- C6 -
4LJ7
2
CLPB_THET8
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
23
PsiBlast_CBE
63.26
44%
-90
- C6 -
4LJ7
2
C:
[34-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
13
PsiBlast_PDB
62.94
44%
-80
- C6 -
4LJA
3
A:
[5-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
14
PsiBlast_PDB
62.88
44%
-88
- C6 -
4FCT
-
CLPB_THET8
A:
[558-825]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
----------------------------------------------
24
PsiBlast_CBE
62.82
44%
-91
- C6 -
4LJ7
2
CLPB_THET8
B:
[34-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
12
PsiBlast_PDB
61.28
44%
-76
- C6 -
4LJ9
3
A:
[5-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
V
T
E
E
D
I
A
E
I
V
S
R
W
----------------------------
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
----------------------
26
PsiBlast_CBE
59.85
44%
-81
- C6 -
4FD2
1
CLPB_THET8
B:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
R
V
-------------------
15
PsiBlast_PDB
59.67
44%
-79
- C6 -
4FD2
1
CLPB_THET8
A:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
R
V
-------------------
25
PsiBlast_CBE
59.43
44%
-81
- C6 -
4FD2
1
D:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
GYEE
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
P
Y
E
R
I
R
D
E
V
F
K
V
----------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
R
V
-------------------