@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0390: (2015-11-30 )
MAFIPFKKSNKCVVTDELFLEVTWEDGKPPEDDSELLGIIEGLEQQYLDSFQHSIEESLPYMTFQQAELLFQSLKDAYGHFQLKKVAICHLEGKQAVSEGEVFASPFIIDSRYQNLLLPLIQSIMIGPDFQSYTYQEKREYFVNQIYPAYKVSLGIQESALPLFPEEGEQIPLDNTFVANRRVASIPTTSSEPRKPNSSFSLKKVYLLMGFLATLAAGAMVSSVSLHAELSKQQEQVNYLYQEWKDIQNLSDKEHQIDVFSRYFLPNYYSGKKENLSDFLSDGDAKYTVPKEGSLQSVILEKVTYDAKTKHYQLTYVLTIKAKEQLTSVRLEFEVKEQPSRKYGYVVTSEPKETPYLMKN
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------.........10--..-......20......-------..30-----------.........40........--50......---..-60........70---.........---------80..-----.----.-----...--------------------.90......----------..100--------.....------...110-----.......-120.......--130...-------....140..----------------------.....150.------------......160..-...-------------------..170---------.........180-.......190...-----------------....200..-----.....210-----...-...-----...220.......230..-.....240..--.-------....-------250-....----.....260--.---------------------......270-..------.----------.----------------.....280.-..-..------.-.290------------....------.....300.....-..310.......320----..-------..----------...-.330.......340.......350.......360---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------MAFIPFKKSN
K
--
C
V
-
V
T
D
E
L
F
L
E
V
T
WEDG-------KPP------------E
D
D
S
E
L
L
G
I
I
E
G
L
E
Q
Q
Y
L
D
--
S
F
Q
H
S
I
E
E
---SL-PY
M
T
F
Q
Q
A
E
L
L
----
F
Q
S
L
K
D
A
YG---------H
F
Q
L
-----
K
----
K
-----
V
A
I
--------------------
C
H
LEGKQAV----------SEGE---------
V
F
AS
P
------
F
I
I
D
S
R
-----
Y
Q
N
L
L
L
P
-
L
I
Q
S
I
MIGPD--FQS
Y
T
Y
-------
Q
E
K
R
E
Y
F
V
N
----------------------QIYP
A
Y
K
V
S
------------LGIQESALPLF-PEE-------------------GEQ-----------IPLDNTFVANRR-VASIPTTSSEPRK-----------------PNSSF
S
L
K
K
-----
V
Y
L
L
M
G
-------
F
L
A
-
T
L
A
-----
A
G
A
M
V
S
S
V
S
L
H
A
E
L
S
K
Q
Q
-
E
Q
V
N
Y
L
Y
Q
E
W
--
K
-------
D
I
Q
N-------L---SDK
E
----
H
Q
I
D
V
F
S
R
--Y---------------------FLPNYYS---GK------K----------E----------------
N
L
S
D
F
L
SDG-DA-
K
Y
------T-VP--------------KEG
S
------
L
Q
S
V
I
L
E
K
VTYDA-KT
K
H
Y
Q
L
T
Y
V
L
T
I
K-----AK-------EQ----------
L
T
S
-
V
R
L
E
F
E
VKEQPSRKY
G
Y
V
V
TSEPKETPYLMKN-----
31
Fugue
81.04
18%
-17
- C3 -
4B3X
3
IF2_THET8
A:
[1-363]
---------------------------------------------------------------------------------------------------
M
A
K
V
R
I
Y
Q
L
A
K
--
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-------
V
A
Y
------------
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
--
K
E
Q
R
G
L
Q
E
---
K
L
-
A
E
E
E
R
R
K
S
L
P
R
----
R
P
P
V
V
V
I
M
G
---------
H
V
D
H
-----
G
----
K
-----
T
T
L
--------------------
L
D
Y
L
R
K
S
R
I
----------
A
E
K
E
GGG
I
T
Q
H
VG
A
F
E
V
K
T
PQ
G
T
V
V
F
I
D
T
P
-----
G
H
E
A
F
T
T
-
I
R
Q
R
G
A
K
V
A
D
--
I
A
V
I
V
I
A
ADDGIM
P
Q
T
E
E
A
I
A
H
----------------------
A
K
A
A
G
A
K
L
I
------------
F
A
I
N
K
I
D
L
P
Q
A
D
P
E
K
-------------------
V
K
R
-----------
Q
L
M
E
R
G
F
V
P
E
E
Y
G
G
D
A
I
V
I
P
I
S
---------------------
A
K
T
G
Q
G
V
Q
D
-----
L
L
E
M
I
L
-------
L
L
A
-
E
L
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
-------------------------------------
G
T
F
R
V
G
D
Y
---------------------
V
V
A
G
E
A
Y
---
G
R
------
I
----------
R
----------------
A
M
M
D
--
A
D
G
-
N
Q
-
R
K
------
E
-
A
G
--------------
P
G
S
A
------
V
Q
V
L
G
F
Q
E
L
P
H
A
G
-
D
----
V
V
E
W
V
P
D
L
E
-----
A
A
-------
K
E
----------
I
A
E
-
E
R
K
E
E
R
K
A
R
E
E
E
E
K
-----
A
R
R
P
R
T
M
A
E
L
L
R
------
29
Fugue
78.98
18%
-23
- C4 -
1ZR6
7
?
A:
[3-481]
-----------------------------------------------------------------------------------------------------
E
A
E
F
N
S
I
N
A
--
C
L
-
A
A
A
D
V
--
E
F
H
E
E
D
S
-------
E
G
W
------------
D
M
D
G
T
A
F
N
L
R
V
D
Y
D
P
A
A
I
A
I
P
R
S
T
E
D
I
A
A
---
A
V
-
Q
C
G
L
D
A
G
V
Q
I
S
----
A
K
G
G
G
H
S
Y
G
SYGFGGEDG
H
L
M
L
ELDRM
Y
----
R
-----
V
S
V
D
DNN
V
A
T
I
Q
GGAR
L
G
Y
T
A
L
E
L
L
D
Q
G
N
R
A
L
----------
S
H
G
T
CPAVG
V
G
G
H
V
L
G
G
G
------
Y
G
F
A
T
H
-----
T
H
G
L
T
L
D
W
L
I
G
A
T
V
V
L
A
D
A
S
I
V
H
V
S
E
-------
T
E
N
A
D
L
F
W
A
L
R
G
GGGGFAIVS
E
F
E
F
N
T
F
EAP
E
I
I
T
T
Y
Q
V
T
T
TWN
R
K
Q
H
V
A
G
L
K
A
L
Q
D
W
A
Q
N
T
M
-
P
R
E
L
S
M
R
L
E
I
N
AN
A
L
N
W
E
G
N
F
F
G
N
A
-----------
K
D
L
K
K
I
L
Q
P
I
M
K
-
K
A
G
G
K
S
T
I
S
K
L
V
E
T
D
W
Y
G
Q
I
N
T
Y
LYGADLN
I
T
Y
N
Y
D
V
H
E
-----
Y
F
Y
A
N
S
-------
L
T
A
P
R
L
S
-----
D
E
A
I
Q
A
F
V
D
Y
K
F
D
N
S
S
V
R
-
P
G
-
R
G
W
W
I
Q
W
--
D
FHGGKNS
A
L
A
A
-------
V
---
S
N
D
E
TAYA
H
R
D
Q
L
W
L
W
--
Q
---------------------
F
Y
D
S
I
Y
D
---
Y
E
------
N
NTSPYPESG
F
E
----------------
F
M
Q
G
F
V
A
T
I
-
E
D
-
T
L
------
P
-
E
D
--------------
R
K
G
K
------
Y
F
N
Y
A
D
T
T
L
T
K
E
E
-
A
Q
K
L
Y
W
R
------
G
-----
N
L
-------
E
K
----------
L
Q
A
-
I
K
A
K
Y
D
----
P
E
D
V
F
G
N
V
V
S
V
E
P
I
A
Y
-----------
25
Fugue
70.15
15%
-1
* C6 *
2OCC
-
COX1_BOVIN
A:
[1-514]
MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
GQPGTLLGD
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
FFMVMPIMIGGFGNWL
V
P
L
M
I
GAPDMAF
P
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
--
L
L
-
L
A
S
S
M
V
E
-----
A
G
AGTGWTV
Y
P
P
LAGNLAHAGA
S
V
D
L
T
I
F
S
L
H
L
A
G
V
S
S
I
L
G
A
I
--
N
F
I
T
T
I
I
N
---
M
K
P
P
A
M
S
Q
Y
Q
T
P
L
F
----
V
W
S
V
M
I
T
A
V
---------
L
L
L
L
-----
S
L
P
V
L
A
-----
A
G
I
--------------------
T
M
L
L
T
D
R
N
L
NTTFFDPAGG
G
D
P
I
---------
L
Y
Q
H
L
------
F
W
F
F
G
H
-----
P
E
V
Y
I
L
I
-
L
P
G
F
G
M
I
S
H
I
--
V
T
Y
Y
S
G
-------
K
K
E
P
F
G
Y
M
G
----------------------
M
V
W
A
M
M
S
I
G
------------
F
L
G
F
I
V
W
A
H
H
M
-
F
T
V
-------------------
G
M
D
-----------
V
D
T
R
A
Y
F
T
S
A
T
M
-
I
I
A
I
P
T
G
V
K
V
F
S
W
-----------------
L
A
T
L
H
G
G
N
I
KWS
P
A
M
M
W
A
L
G
-------
F
I
F
-
L
F
T
-----
V
G
G
L
T
G
I
V
L
A
N
S
S
L
D
I
V
L
-
H
D
T
Y
Y
V
V
A
H
F
--
H
-------
Y
V
L
S
MG
A
V
F
A
I
M
---
G
G
F
V
----
H
W
F
P
L
F
S
G
--
Y
TLN
D
T
W
A
K
I
H
F
A
I
M
F
V
G
V
N
M
T
F
F
P
Q
H
F
L
---
G
L
------
S
----------
G
M
P
R
-------------
R
Y
S
D
Y
P
D
A
Y
-
T
M
-
W
N
------
T
-
I
S
--------------
S
M
G
S
------
F
I
S
L
T
A
V
M
L
M
V
F
I
-
I
W
E
A
F
A
S
K
R
E
V
L
--------
T
-------
V
D
----------
L
T
T
-
T
N
L
E
W
L
N
G
C
P
P
P
Y
H
T
F
-------
E
E
P
T
Y
V
N
L
K
-----
27
Fugue
66.28
13%
-23
* C4 *
4CVH
3
ISPD_HUMAN
A:
[1-411]
--------------------------------------------------------------------------------------------SMHPQA
V
A
A
V
L
P
A
G
P
T
P
K
QF
C
P
-
I
L
E
R
P
L
I
S
Y
T
L
Q
A
L
-------
E
R
V
------------
C
W
I
K
D
I
V
V
A
V
T
G
E
N
M
E
V
M
K
--
S
I
I
Q
K
Y
Q
H
KR
I
S
L
-
V
E
A
G
V
T
R
H
R
S
I
----
F
N
G
L
K
A
L
A
E
---------
D
Q
I
N
-----
S
----
K
LSKPE
V
V
I
--------------------
I
H
D
A
V
R
P
F
V
----------
E
E
G
V
---------
L
L
K
V
V
------
T
A
A
K
E
H
G
A
A
G
A
I
R
P
L
V
S
T
-
V
V
S
P
S
A
D
G
C
L
--
D
Y
S
L
E
R
-------
A
R
H
R
A
S
E
M
P
----------------------
Q
A
F
L
F
D
V
I
Y
------------
E
A
Y
Q
Q
C
S
D
Y
D
L
-
E
F
G
-------------------
T
E
C
-----------
L
Q
L
A
L
K
Y
C
C
T
K
---
A
K
L
V
E
G
S
P
D
L
W
K
-----------------
V
T
Y
K
R
D
L
Y
A
-----
A
E
S
I
I
K
-------
E
R
I
-
S
------------
Q
E
I
C
V
V
M
D
T
E
E
D
N
-
K
H
V
G
H
L
L
E
E
V
L
K
S
-------
E
L
N
H
-------
V
---
K
V
T
S
----
E
A
L
D
Q
C
Y
N
--
F
---------------------
V
C
V
N
V
T
T
---
S
D
------
F
----------
Q
----------------
E
T
Q
K
L
L
S
M
L
-
E
E
S
S
L
------
C
-
I
L
--------------
Y
P
V
V
------
V
V
S
V
H
F
L
D
F
K
L
V
P
-
P
S
Q
K
M
E
N
L
M
Q
I
R
E
F
-----
A
K
-------
E
V
K
ERN
I
L
L
Y
G
L
L
I
S
-
Y
P
Q
D
D
Q
K
L
Q
E
S
L
R
Q
G
A
I
I
I
A
S
L
I
K
E
R
N
S
G
L
I
G
Q
L
L
I
A
30
Fugue
65.90
14%
10
- C2 -
4XB6
2
?
C:
[1-353]
----------------------------------------------------------------------------------------------------
M
Y
V
A
V
K
G
G
E
K
--
A
I
-
D
A
A
H
A
L
Q
E
S
R
R
R
G
D
-------
T
D
L
------------
P
E
L
S
---------
V
A
Q
I
E
Q
--
Q
L
N
L
A
V
D
R
---
V
M
-
T
E
G
G
I
A
D
R
E
L
A
----
A
L
A
L
K
Q
A
S
G
D--------
N
V
E
A
-----
I
----
F
-----
L
L
R
--------------------
A
Y
R
T
T
L
A
K
L
----------
A
V
S
E
P--------
L
D
T
T
G
------
M
R
L
E
R
R
-----
I
S
A
V
Y
K
D
-
I
P
G
G
Q
L
L
G
P
T
--
Y
D
Y
T
H
R
-------
L
L
D
F
T
L
L
A
N
----------------------
G
E
A
P
T
L
T
T
A
------------
D
S
E
Q
Q
P
S
P
H
V
F
-
S
L
L
-------------------
A
R
Q
GLAKFEEDSG
A
Q
P
D
D
I
T
R
T
P
P
V
Y
-
P
C
S
R
S
S
R
L
Q
Q
L
M
R
-----------------
G
D
E
G
Y
L
L
A
L
-----
A
Y
S
T
Q
R
GYGRNHP
F
A
G
-
E
I
R
-----
S
G
-
Y
I
D
V
S
I
V
P
E
E
L
G
F
A
V
-
N
V
G
E
L
L
M
T
E
C
--
E
-------
M
V
N
G
-------
F
---
I
D
P
P
----
G
E
P
P
H
F
T
R
--
G
---------------------
Y
G
L
V
F
-----
G
M
------
S
----------
E
----------------
R
K
A
M
A
M
A
L
V
-
D
R
-
A
L
------
Q
-
A
P
--------------
E
Y
G
-------------
E
H
A
T
G
P
A
-
Q
D
E
E
F
V
L
A
H
A
D
N
V
E
-----
V
A
-------
G
F
----------
V
S
H
-
L
K
L
P
H
Y
V
D
F
Q
A
E
L
E
L
L
K
R
L
Q
Q
E
Q
N
H
------------
28
Fugue
59.74
14%
-5
- C1 -
2XQH
4
?
A:
[23-280]
-----------------------------------------------------------------------------------------------------------
S
D
A
-----
K
A
S
G
E
F
S
V
A
V
G
N
G
A
-------
R
A
T
------------
E
K
A
S
T
A
V
G
-----
S
W
A
A
A
D
--
G
K
Q
S
T
A
L
G
---
V
G
-
T
Y
A
Y
A
N
A
S
T
A
L
G
SV
A
F
V
D
N
T
A
T
Y
G
---------
T
A
A
G
-----
N
----
R
-----
A
K
V
-------------------------
D
K
D
A
----------
T
E
G
T
---------
A
L
G
A
K
------
A
T
V
T
N
K
-----
N
----------
S
V
A
L
G
A
N
----
S
V
T
T
-------
R
D
------
N
----------------------
E
V
Y
I
G
Y
K
T
G
------------
T
E
-------------------------------------------------
S
D
K
T
Y
G
T
R
V
-
L
G
G
L
S
D
G
T
R
N
S
D
A
-----------------
A
T
----------------
V
G
-------
Q
L
N
-
R
K
V
-----
G
G
V
Y
D
D
V
K
A
R
I
T
V
E
S
E
K
Q
-
K
K
--
Y
T
D
Q
K
T
--
S
-------
E
V
N
E
-------
K
---
V
E
A
R
----
T
T
V
G
V
--------------------------------------------------------------------------------
D
S
-
D
G
-
K
L
------
T
--
R
--------------
A
E
G
A
------
T
K
T
I
A
V
N
D
G
L
V
A
L
-
S
G
R
T
D
R
I
D
Y
A
V
G
A
I
-----
D
G
-------
R
V
----------
T
R
N
-
T
Q
S
I
E
K
N
S
K
A
I
A
A
N
T
R
T
--------------------
22
Fugue
58.73
28%
5
- C5 -
4EC6
-
?
A:
[214-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
----
S
K
I
D
T
F
G
R
--
Y
---------------------
F
L
T
Y
Y
F
S
---
Q
E
KN
Q
E
N
Y
Q
----------
S
----------------
S
L
R
T
Y
V
S
E
K
V
D
I
-
S
D
------
W
-
K
A
--------------
L
G
K
T
------
L
K
S
V
N
Y
Y
G
S
E
Q
T
K
-
K
G
--
Y
S
V
E
Y
L
L
N
V
S
-----
V
D
-------
N
R
-----------
S
K
M
Q
K
I
T
F
E
V
E
P
T
---
K
N
G
F
L
V
T
T
Q
P
K
L
T
D
F
S
F
N
------
12
HHSearch
58.34
15%
-22
- C5 -
3UB1
-
?
A:
[6-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
----
T
Q
A
F
S
F
A
E
--
E
---------------------
F
A
W
D
Y
F
S
---
R
Y
------
P
SD
T
Q
D
F
V
---
R
----------------
R
I
T
K
Y
T
T
E
Q
-
L
A
-
N
E
------
M
N
N
G
--------------
T
Y
S
D
------
V
I
Y
T
S
A
F
Y
F
E
K
Y
S
--
E
N
Q
V
N
V
S
V
K
A
R
V
R
V
Y
T
P
K
A
G
QEQDQ
L
Q
Y
D
----------
T
N
L
-
V
D
Y
Y
L
E
V
P
I
V
F
D
K
D
M
N
M
A
V
D
A
L
P
V
M
T
A
P
P
E
K
A
-----
17
HHSearch
57.57
13%
-41
- C5 -
3K7C
4
?
A:
[7-93]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
P
E
D
L
A
K
--
N
---------------------
F
T
K
D
L
Y
S
---
G
D
------
T
----------
K
----------------
S
V
M
S
Y
I
D
L
S
-
E
A
-
K
S
D
E
E
K
T
F
V
-
S
D
K
I
T
Q
V
V
A
E
N
A
A
K
A
K
R
M
G
G
------
V
K
D
I
Q
I
E
E
K
T
I
N
---
K
D
S
A
K
I
R
V
L
V
L
F
N
-----
N
D
-------
N
N
----------
Q
S
S
-
N
V
F
L
A
K
K
D
R
K
W
L
V
L
L
K
---------------------
13
HHSearch
53.00
14%
-13
- C5 -
3UB1
-
?
A:
[153-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
----
K
K
I
T
D
S
V
S
--
Q
---------------------
F
F
K
A
Y
Y
E
---
Q
N
------
Q
----------
T
----------------
Q
I
D
Y
F
L
V
D
G
-
A
D
-
I
K
---------
G
--------------
A
G
Q
K
------
F
S
F
N
K
I
D
R
I
N
I
Y
K
L
S
D
K
E
F
L
A
I
V
D
L
N
V
D
-----
S
F
-------------------
G
N
A
-
I
K
Q
G
F
N
L
T
V
V
Q
E
-
G
D
K
F
L
V
K
T
L
E
P
R
T
S
N
I
D
L
N
-----
1
PsiBlast_PDB
50.86
26%
38
- C5 -
4EC6
-
?
A:
[215-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
S
K
I
D
T
F
G
R
--
Y
---------------------
F
L
T
Y
Y
F
S
---
Q
E
------
K
----------
N
Q
E
N
Y
Q
S
S
L
RTYVSEKV
D
I
S
D
W
K
A
L
G
-
K
T
-
L
K
------
S
-
V
N
--------------
Y
Y
G
S
------
E
Q
T
------------
K
K
G
Y
S
V
E
Y
L
L
N
V
S
-----
V
D
-------
N
R
----------
S
K
M
-
Q
K
I
T
F
E
V
--
E
P
T
K
N
-
G
F
L
V
T
T
Q
P
K
L
T
D
F
---------
3
PsiBlast_PDB
49.40
25%
-6
- C5 -
2Q9Q
-
PSF2_HUMAN
A:
[20-131]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
S
L
D
K
-----
I
Y
L
I
G
G
-------
D
L
G
-
P
F
N
-----
P
G
L
P
V
E
V
P
L
W
L
A
I
N
L
K
Q
R
-
Q
K
C
R
L
L
P
P
E
W
--
M
-------
D
V
E
K
-------
L
E
K
M
R
D
H
E
----
R
K
E
E
T
F
T
P
--
M
---------------------
P
S
P
-
Y
Y
M
---
E
L
------
T
----------
K
----------------
L
L
L
N
H
A
S
D
N
--------------
I
P
--------------
K
A
D
E
------
I
R
T
L
V
--
K
D
M
W
D
T
-
R
I
A
K
L
R
V
S
A
D
S
F
V
R
-----
Q
Q
-------
E
A
----------
H
A
K
-
L
D
N
L
T
L
M
E
I
N
T
S
G
T
F
L
T
Q
A
L
N
H
M
Y
K
L
R
T
N
L
Q
------
4
PsiBlast_PDB
47.93
25%
-2
- C5 -
2E9X
-
PSF2_HUMAN
B:
[20-131]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
S
L
D
K
-----
I
Y
L
I
G
G
-------
D
L
G
-
P
F
N
-----
P
G
L
P
V
E
V
P
L
W
L
A
I
N
L
K
Q
R
-
Q
K
C
R
L
L
P
P
E
W
--
M
-------
D
V
E
K
-------
L
E
K
M
R
D
H
E
----
R
K
E
E
T
F
T
P
--
M
---------------------
P
S
P
-
Y
Y
M
---
E
L
------
T
----------
K
----------------
L
L
L
N
H
A
S
D
N
--------------
I
P
--------------
K
A
D
E
------
I
R
T
L
V
--
K
D
M
W
D
T
-
R
I
A
K
L
R
V
S
A
D
S
F
V
R
-----
Q
Q
-------
E
A
----------
H
A
K
-
L
D
N
L
T
L
M
E
I
N
T
S
G
T
F
L
T
Q
A
L
N
H
M
Y
K
L
R
T
N
L
Q
------
2
PsiBlast_PDB
45.96
27%
-1
- C5 -
2EHO
-
PSF2_HUMAN
C:
[21-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
S
L
D
K
-----
I
Y
L
I
G
G
-------
D
L
G
-
P
F
N
-----
P
G
L
P
V
E
V
P
L
W
L
A
I
N
L
K
Q
R
-
Q
K
C
R
L
L
P
P
E
W
--
M
-------
D
V
E
K
-------
L
E
K
M
R
D
H
E
----
R
K
E
E
T
F
T
P
--
M
---------------------
P
S
P
-
Y
Y
M
---
E
L
------
T
----------
K
----------------
L
L
L
N
H
A
S
D
N
--------------
I
P
--------------
K
A
D
E
------
I
R
T
L
V
--
K
D
M
W
D
T
-
R
I
A
K
L
R
V
S
A
D
S
F
V
R
-----
Q
Q
-------
D
N
----------
L
T
L
-
M
E
I
N
T
S
G
T
F
L
T
Q
A
L
N
H
M
Y
K
L
R
T
N
--------------
11
PsiBlast_PDB
41.80
32%
-11
- C5 -
1SJI
-
CASQ2_CANFA
A:
[143-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Q
I
K
L
I
G
F
F
K
S
E
E
S
E
Y
Y
K
--
A
F
E
E
A
A
E
H
---
F
Q
-
P
Y
I
K
F
F
A
T
F
D
K
----
G
V
A
K
K
L
S
L
K
---------
M
N
E
V
-----
D
----
F
-----
Y
E
P
--------------------
F
M
D
E
P
I
A
I
P
----------
D
K
P
Y
---------
T
E
E
E
L
------
V
E
F
V
K
E
-----
H
Q
R
P
T
L
R
-
R
L
R
P
E
D
M
F
E
T
--
W
E
D
D
L
N
-------
G
I
H
I
V
A
F
A
E
----------------------
R
S
D
P
D
G
Y
E
F
------------
L
E
I
L
K
Q
V
A
R
D
N
-
T
D
N
-------------------
P
D
L
-----------
S
I
V
W
I
D
P
D
D
F
P
L
-
L
V
A
Y
W
E
K
T
F
K
I
D
L
-----------------
F
K
P
Q
I
G
V
V
N
-----
V
T
D
A
D
S
-------
V
W
M
-
E
I
P
-----
D
D
D
D
L
P
T
A
E
E
L
E
D
W
I
E
D
V
-
L
S
G
K
I
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.97
28%
82
- C5 -
1COY
2
CHOD_BREST
A:
[161-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
W
F
E
S
T
E
W
--
Y
-------
K
F
A
R
-------
T
---
G
R
K
T
----
A
Q
R
S
G
F
T
T
--
A
---------------------
F
V
P
N
V
Y
D
F
E
Y
M
K
------
K
----------
E
---------------------------
A
-
A
G
------
Q
-
V
T
--------------
K
S
G
L
------
G
G
E
V
I
Y
G
N
---
N
A
-
G
K
K
S
L
D
K
T
Y
L
A
Q
A
A
-----
A
T
-------
G
K
----------
L
T
I
-
T
T
L
H
R
V
T
K
V
A
P
A
T
G
S
G
Y
S
V
T
M
E
Q
I
D
E
Q
G
N
V
V
A
-----
6
PsiBlast_PDB
39.25
28%
81
- C5 -
3COX
1
CHOD_BREST
A:
[161-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
W
F
E
S
T
E
W
--
Y
-------
K
F
A
R
-------
T
---
G
R
K
T
----
A
Q
R
S
G
F
T
T
--
A
---------------------
F
V
P
N
V
Y
D
F
E
Y
M
K
------
K
----------
E
---------------------------
A
-
A
G
------
Q
-
V
T
--------------
K
S
G
L
------
G
G
E
V
I
Y
G
N
---
N
A
-
G
K
K
S
L
D
K
T
Y
L
A
Q
A
A
-----
A
T
-------
G
K
----------
L
T
I
-
T
T
L
H
R
V
T
K
V
A
P
A
T
G
S
G
Y
S
V
T
M
E
Q
I
D
E
Q
G
N
V
V
A
-----
19
HHSearch
36.21
14%
-7
- C5 -
3JST
1
PHS_BRUME
A:
[4-53]
-----------------------------------------------------------------------------------------------------------------------------------------
N
R
------------
L
T
E
S
E
M
N
E
A
L
R
A
L
D
G
W
Q
K
V
--
D
G
R
E
A
I
T
R
---
S
F
-
K
F
K
D
F
S
T
A
F
G
F
----
M
A
Q
A
A
L
Y
A
E
---------
K
L
D
H
-----
H
----
P
-----
E
W
F
--------------------
N
A
Y
N
R
V
D
V
T
----------
L
A
T
H
---------
S
E
N
G
V
------
T
E
L
D
I
K
-----
M
A
R
K
M
N
A
-
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
35.72
13%
-12
* C5 *
2D16
1
?
A:
[25-54]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
F
T
V
D
D
L
----
A
R
A
L
L
T
A
V
P
---------
G
I
K
F
----------
G
-----
I
A
M
--------------------
N
E
A
K
P
Q
L
T
R
----------
Y
T
G
N
---------
D
P
E
L
E
------
A
L
A
A
K
N
-----
A
V
K
I
G
A
G
-
H
V
F
V
I
L
M
K
N
A
--
Y
P
I
N
V
L
-------
N
T
I
K
N
H
P
A
V
----------------------
A
M
I
Y
G
A
S
E
N
------------
P
F
Q
V
I
V
A
E
T
E
L
-
G
R
A
-------------------
V
I
G
-----------
V
V
D
G
K
A
A
N
K
I
E
T
-
D
E
Q
K
K
E
R
R
E
L
V
E
K
-----------------
I
G
Y
K
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
33.52
28%
76
- C7 -
2XQ0
1
LKHA4_YEAST
A:
[352-417]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
--
S
-------
D
L
Q
N
-------
S
---
I
D
S
M
----
K
D
--------------------------------
P
E
R
F
S
---
T
L
------
V
----------
Q
----------------
N
L
N
D
N
T
D
P
D
-
D
A
-
F
S
------
T
-
V
P
--------------
Y
E
K
G
F
N
L
L
F
H
L
E
T
I
L
G
G
K
A
E
F
D
P
-
F
I
R
H
Y
F
K
K
F
A
K
K
S
L
-----
D
T
-------
F
Q
----------
F
L
D
-
T
L
Y
E
F
Y
P
E
K
K
E
I
L
D
S
V
D
W
E
T
W
L
Y
K
P
G
M
P
P
R
P
H
-----