@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0396: (2015-11-30 )
MFSWLEALYYTLIQLAKVNRLNALFLVSVVGYLCYQGIKLVRKTIRNFFQLMKGFIGDRENIKKCIKNKKEALVHSWKHRQDIDWKSTGKDKSKQLWNLMKRLATVAPSFLFLLLGNVLFRLIYQLPFVKQDRKRFDKEMKPLLYFKNYRSFVFMGIGFSFIAFILTNYFVTVLRAAIRFLYFSIMTLRDNSQVVSFNVDSLLIQNLFNARVFVIAPILAVPIFLIGLVVAWRSAWVNFEQYRDYNHNEEGDDRFATVKEIHQQYKKVPNKTETYPGEGGVPVLHETRKNLTGLTLKSQMLWQNRTFSRYLTNAERILGLLSTPSGDYYIDDSTTNLITMGITRSGKGEAHIAPIIDINSRAEIQPSLIIADPKGEHYQSSYKTMRRRGYDVNVLSFQNMDWSMSYNPLALAIAAAKKGYYEMTQTRVNAVAEAIYRKTKPGSGNGNAKYWEDTSISLFNAIAMALMDRANETVRNGETDAWDTVTVRNIAKFLTDLGSEEVFVNDFGEIVENPDKNQQVKKKSKITVYFDNLRKINQEQFSKFRDMADLNFRSSDFASEETKGNVFSSMMSGINLFLQDNIAKLTSKNSIDLESVGFPRRLSIKFRSSSNVAMRNEYTHKTAKVTITSQAVWGKTTKQVIHVDAATALIDGEGYLTYVIEPQLPDQFLVTIDFNHENNGGSAIRHKTFQFSAEKVYKKRGNVITLDDYTKKPVLDHIKVTVLNKQDDNLLQKEDIDLIYSDNPKVIYLVTPPNRTEYNSIVSLFLDQLFNANYELALSNGRKCVNRILHILDEFTNIPAIPHMDTKISIGLGQNILYYLWIQNLKQLVSEYGENTAETIRENCSLKVYIKSTAPATNEYFSKELGTRTITRRRRSSNILDEANPNVSIENPRQELLTPTQLSKLQEGEAVILRGVKGRDNAGRKITTDPIFLHEKTSLPYRYMFLQEEFDQSMALADIPVESGHRDLDLQDIAVGAQSTFNKIIDWRMALTDRMRTNGKIPQLASRKQTIKALSQSQFTSPADLTQAVIAEVFDEEDDDDLFFVDDVM
Atome Classification :
(20 SA)
--------------------------.........10.....--...20........30.....---..--.40..-----...--...50........-60........70..-----------......-----80........90...---.....100.--------......110..------.-....120.......130----------------------------.........140---...-.....150.......160--...--....170.......180.......---190.-------.....------------.200..---------.....210.......220------........230.......240......--.250-----------------------.......260...-.-...270.....---..280......------.290...-.--...300.....--..310.......320...-....330------------.........340....----...350.......360--.......370.-......380......----.390....------...400.......410.......420.......430..---.....440.---...---------...450......-----.460..---.....470.......480......--.490.--......500.......510.......520---.......530.....--..540------........550.......560.......570.....----..580...--....590........600........610.......620........--.630.-.....-------------------.--640---...-------....650.......660.......670.....------..680--........690.....-..700.......710.......-.720.......730.......740...--------...--.750--.....-....760...-..-----..770.......---780.......790.......800----.........810.......820-.........830..-------.....840..-.....---850..-.--......860.---.....----.870.......880.--......890.......900.--------......-910...-----....920.......930-------.......940.......950.......960.......970.-......980.......990.......1000......1010......1020.....---.1030......1040......----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------M
F
S
W
L
E
A
L
Y
Y
T
L
I
Q
L
A
--KVNR
L
N
A
L
F
L
V
S
V
V
G
Y
L
C
Y
Q
---
G
I
--
K
L
V
R
K
-----
T
I
R
--
N
F
F
Q
L
M
K
G
FIG
D
R
-
E
N
I
K
K
C
I
K
N
K
K
E
A
L
-----------
V
H
S
W
KH-----RQDIDWKSTGK
D
K
S
K
---
Q
L
W
N
L
M
K
R
L
--------
A
T
V
A
P
S
F
L
F
L
L
------
L
-
G
N
V
L
F
R
L
I
Y
QLPF
V
K
------------------------------
Q
D
R
K
R
F
D
K
E
M
K
----
P
L
L
-
Y
F
KNY
R
S
F
V
F
MG
I
G
F
S
F
I
--
A
F
I
--
L
T
N
Y
F
V
T
V
L
R
A
A
I
R
F
L
Y
F
S
I
M
T
LR---DN
S
Q
-------
V
V
S
F
N
------------
V
D
S
L
L
I
---------
Q
N
L
FNA
R
V
F
V
I
A
P
I
L
A
V
-------
P
I
F
L
I
G
L
V
V
A
W
R
S
AWV
N
F
E
Q
YRDYNHN--EEGD-----------------------
D
R
F
A
T
V
K
E
I
H
Q
Q
Y
-
K
-KVPNKTETYPG---EGGV
P
V
L
H
E
T
R------KNLTGL
T
-
L
--
K
S
Q
M
L
WQNR
T
F
--
S
R
Y
L
T
N
A
E
R
I
L
G
L
LSTPS-G
D
Y
Y
I--------------DDSTT
N
L
I
T
M
G
ITRSG----KGE
A
H
I
A
P
I
I
DINSRA--EIQ
P
S
L
I
I
ADP-KG
E
H
Y
Q
S
S
Y
K
T
M
R
RR----GYD
V
N
V
L
S
------FQNMDWSMSYN
P
L
A
L
A
I
A
A
AKKG
Y
Y
E
M
T
Q
T
R
V
N
A
V
A
E
A
---
I
Y
RKTKPGS---GNG---------N
A
K
Y
W
EDT
S
I
S
L
-----
F
N
A
I
A
M
---
A
L
M
D
RAN
E
T
VRNGETDAW
D
T
V
T
V
R
--
N
I
A
K
F
--
L
T
D
LGSEE
V
F
V
N
D
F
G
E
IVENPDK
N
Q
Q
V
KK---KS
K
I
T
V
Y
F
D
N
L
R
KI
N
--
Q
E
Q
F
-------
S
K
F
R
D
M
ADLNFRSSDFASEETK
G
N
V
F
S
S
M
M
S
G
I
N
L
F
----
L
Q
D
N
I
A
K
L--TSKNSI-D
L
E
SVGFP
R
-
R
L
S
I
K
F
RSSSN
V
A
MRNEYTH--
K
T
A
K
V
T
I
T
--SQAVW-GKT
T
K
-------------------
Q
--
V
I
H
---
V
D
A
-------
A
T
A
L
IDGE
G
Y
L
T
Y
V
IEPQLP
D
Q
F
L
V
T
I
D
F
NHE------NNGG---S
A
I
R
HK
T
F
QF
S
A
E
K
V
Y
-
K
KRG
N
V
I
T
LDDYTK-KP
V
L
D
H
I
-
K
V
T
V
LNKQDDNLLQKED
I
D
L
I
YSDN
P
K
--------
V
I
Y
--
L
V----TPPNR-
T
E
Y
N
S
I
V
S
L
F
-
L
D
-----
Q
L
FNAN
Y
E
L
A
LS---N
G
R
K
C
V
N
R
I
L
H
I
L
D
E
FTNIPA------IPHMD
T
K
I
S
I
GLGQ
N
I
L
Y
Y
L
---
W
I
Q
N
L
K
Q
L
V
S
E
YGE-------
N
T
A
E
T
I
R
ENC-
S
L
K
V
Y
---
I
--KS-T--APA
T
N
E
Y
F
S
K
---
E
LG
T
R
----
T
I
T
R
RRRSSNILDEA--NPNVSIE
N
P
R
Q
ELL
T
P
T
Q
L
S
--------
K
LQEG
E
-
A
V
I
L
RG-----VKGRDNAG
R
K
ITTD
P
I
F
-------
L
HEKTSL
P
Y
R
Y
M
F
L
Q
E
E
FDQSMALADIPVESGHRDL
D
L
Q
D
I
-AV
G
A
Q
S
T
F
N
K
I
I
D
W
R
M
A
L
T
D
RMRTNGKI
P
Q
L
A
S
R
K
Q
T
I
K
A
L
S
Q
SQFT
S
P
A
D
L
T
Q
A
---
V
I
A
E
V
FDEEDDD
D
L
F
F
VDDVM----------
44
Fugue
83.80
17%
-33
* C2 *
4F1N
1
?
A:
[12-1046]
-----------------------D
T
H
A
I
Y
K
V
E
N
R
H
D
Y
G
T
K
G
T
--
K
V
D
I
L
T
N
H
I
L
L
A
V
G
N
D
V
P
T
E
---
K
I
DK
E
L
V
P
K
LDGWW
K
T
A
--
F
I
F
T
Y
H
I
D
F
K
L
S
K
-
P
K
K
Y
E
L
I
E
A
L
L
D
E
D
-----------
E
I
L
Y
K
Y
-----
R
D
R
I
A
F
N
G
E
D
T
I
Y
S
H
VPL
E
E
F
T
L
F
D
G
C
--------
W
E
E
M
V
S
Q
I
T
L
K
------
F
S
G
K
V
G
L
K
D
I
Y
N
-
D
T
T
T
------------------------------
Q
D
T
E
V
Q
E
S
R
M
S
----
A
---------------
I
D
K
T
C
L
--
L
S
L
--
L
G
A
K
F
M
S
T
D
D
L
I
F
Q
V
Q
G
N
K
F
F
I
F
N
---
N
F
A
K
-------
A
I
P
F
Q
------------
I
G
G
Y
L
L
---------
Q
G
F
T
V
S
L
T
H
V
Y
G
-----------------
G
V
A
L
N
T
V
S
V
P
A
P
F
I
K
H
T
K
Y
L
P
-----
G
D
-----------------------
P
R
F
K
N
--------------
N
E
K
E
Q
F
T
L
---
M
D
W
I
I
E
C
Y
H
Q
S
------
K
A
I
R
D
I
R
-
Y
NP
K
T
A
P
P
P
S
V
K
D
L
--
N
Y
F
V
E
K
N
T
D
I
S
A
L
L
K
G
L
K
V
Y
R
P
Y
I
--------------
N
R
S
S
K
G
I
V
--
G
F
T
R
---------------------------
E
S
A
V
S
M
R
N
-
T
I
D
Y
F
K
R
K
Y
D
I
T
L
K
Y
----
P
-
D
M
K
L
V
N
------
L
G
G
K
N
D
V
V
P
--
P
E
C
L
T
I
V
P
G
Q
K
L
K
G
Q
I
F
D
T
K
T
Y
I
D
F
S
A
---
I
R
---------------------------
P
T
E
K
F
D
L
-----
I
S
R
L
S
M
---
P
A
I
K
R
G
---
L
T
D
S
E
N
S
A
Y
Q
F
M
R
V
P
--
S
R
I
L
D
--
A
P
--------------
V
V
Q
F
K
E
S
T
F
E
Y
K
D
---
K
S
Y
G
T
---------
K
--
H
E
E
S
-------
K
G
N
W
N
M
K
G
H
Q
F
I
S
T
P
A
K
Q
V
N
L
R
A
I
F
I
N
N
A
N
T
A
P
P
A
S
----
M
E
S
E
L
D
I
S
--
M
D
K
F
A
S
-
D
V
K
Q
L
G
-------
V
D
F
N
V
S
G
K
P
I
L
I
N
Q
F
G
P
--
P
I
K
P
T
F
E
T
--
S
P
G
------------------------------
E
I
S
---
L
L
N
-------
L
L
E
N
I
P
S
N
T
Y
I
L
Y
V
L
R
R
G
N
D
S
A
V
Y
D
R
L
K
Y
I
T
D
------
L
K
F
G
A
L
N
S
C
V
V
W
D
N
F
----------
K
K
N
S
I
Q
Y
N
S
N
V
V
M
-
K
M
N
L
K
L
L
G
S
N
H
S
L
S
I
E
N
N
K
L
L
I
D
K
E
-----
S
N
L
P
I
--------
L
V
L
G
S
D
V
----
T
H
Y
P
E
-
K
D
Q
N
S
I
A
S
L
V
-
G
S
Y
D
DKF
T
Q
F
P
G
D
Y
M
L
Q
D
G
---
P
G
E
E
I
I
T
N
V
G
S
L
M
L
N
R
L
K
I
Y
Q
------
K
H
N
N
G
K
-----
L
P
T
K
I
M
Y
F
R
D
GV
S
V
D
Q
F
S
Q
V
V
K
-----------------
I
E
V
K
-
S
I
K
E
S
---
V
--
R
K
-
F
--
G
P
Q
L
N
G
G
N
K
Y
---
D
P
P
V
T
----
C
I
A
T
V
K
R
N
Q
V
R
F
I
P
I
--
Q
E
N
A
K
--
N
E
K
G
E
E
V
A
V
Q
S
M
G
--------
N
V
M
P
G
--
T
V
V
D
R
G
-----
I
---------------------------
T
S
V
A
H
F
D
F
F
I
Q
S
--
H
Q
A
L
K
G
T
G
V
P
----
C
H
Y
W
C
L
Y
D
E
-
N
Q
S
T
S
D
Y
L
Q
E
I
C
N
N
L
C
Y
I
F
G
R
S
T
T
S
V
K
V
P
A
P
V
Y
Y
A
D
L
L
C
T
R
A
T
C
F
F
K
A
G
F
E
L
N
M
A
Q
AT
V
S
K
N
V
L
L
P
Q
V
N
D
N
I
---
K
S
V
M
YYI-------
48
Fugue
78.29
16%
-30
- C2 -
4ZHJ
-
?
A:
[20-1350]
HMFT
N
V
K
S
TIR
R
V
D
P
EALNG
R
Q
L
L
K
V
V
Y
V
V
L
E
S
Q
Y
Q
S
A
L
S
A
A
V
R
N
I
N
R
T
N
S
S
L
A
I
Q
L
T
G
Y
L
I
E
E
LP
E
N
Y
--
A
N
F
K
H
-----
D
V
S
E
A
N
L
F
I
A
S
L
I
F
I
E
D
L
A
D
K
V
V
E
A
V
T
P
Y
R
D
N
L
D
A
A
I
V
F
PSM
P
Q
V
M
R
L
N
K
MGSFS
M
A
Q
L
G
F
Q
D
A
M
L
K
L
L
R
---
T
L
P
T
V
L
K
Y
L
P
V
E
K
A
Q
D
A
R
N
F
M
L
S
F
Q
Y
W
L
G
GS
Q
E
N
L
-
E
N
F
L
L
M
L
T
D
K
Y
V
Y
P
D
LGLDVYPD
M
G
I
W
H
PLSMQMFEN
V
K
D
Y
L
E
W
Y
N
Q
R
P
D
I
S
E
D
L
K
DPL
A
P
C
I
-
G
L
I
M
Q
R
T
H
L
V
T
G
D
D
A
H
Y
V
--
G
M
V
Q
E
L
E
A
M
G
A
R
V
I
C
V
F
S
G
G
L
D
F
S
K
P
V
N
E
YFW
D
K
S
E
PLPIVD
A
V
V
S
L
T
GFALVGQD
H
P
R
A
I
E
S
L
K
K
L
N
R
P
Y
M
C
A
L
P
L
V
F
Q
H
P
I
Q
V
A
L
Q
I
A
I
P
E
L
D
GAIE
P
I
I
L
I
A
L
Q
D
R
L
E
A
I
A
Q
R
A
M
K
W
A
N
L
R
K
K
--
P
K
L
D
K
K
V
A
I
T
V
F
SFPPDKGNVGTAAYL
D
V
F
G
S
I
Y
E
V
M
K
G
L
-
Q
-
G
N
G
Y
D
V
Q
D
L
P
G
S
A
K
E
L
M
E
A
V
I
H
D
A
Q
------
A
Q
Y
N
S
P
E
-
L
--
N
I
A
H
R
M
S
V
E
Q
Y
--
E
R
L
T
P
Y
S
V
R
L
E
E
N
W
G
K
P
P
-
G
H
L
N
S
--------------
D
G
Q
--
N
L
L
I
Y
G
K
E
F
-------
G
N
V
F
I
G
V
Q
P
T
F
G
Y
E
G
--
D
P
M
R
L
L
F
S
R
S
A
-
S
P
H
H
G
F
A
A
Y
Y
T
Y
L
N
H
----
I
W
K
A
D
A
V
L
------
H
F
G
T
H
G
S
L
E
F
M
P
G
D
N
L
I
G
T
I
P
N
L
Y
Y
Y
A
----
A
N
N
P
S
E
A
---
T
I
A
K
R
R
G
Y
A
---
S
T
I
---------
S
Y
L
T
P
P
A
E
N
A
G
L
-----
Y
K
--
G
L
---
Q
E
L
N
E
L
I
G
S
Y
Q
T
L
K
D
S
G
R
G
I
Q
I
V
N
--
T
I
M
D
Q
--
A
R
I
C
N
L
D
Q
----
D
V
N
L
P
D
I
N
A
E
E
M
D
Q
G
Q
R
---
D
T
I
V
G
S
V
Y
R
K
L
M
E
I
E
--
S
R
L
L
P
C
G
L
H
V
I
G
Q
P
P
S
A
E
E
A
I
A
T
L
V
N
I
A
S
L
D
R
E
D
E
G
I
W
A
L
P
T
L
I
A
E
S
----
I
G
R
N
M
E
E
I
--
Y
R
N
S
D
K
G
I
L
A
D
V
E
L
L
Q
-
D
I
T
L
A
T
R
A
A
V
A
A
L
V
Q
E
Q
I
N
A
DG
R
V
S
F
V
S
K
L
--
N
F
F
K
I
-
G
K
K
A
P
-------------------
W
--
V
K
S
---
L
C
D
S
GYPNVN
E
E
K
L
K
P
L
F
E
Y
L
E
F
C
L
E
Q
V
C
A
D
N
E
F
G
G
L
L
Q
A
L
E
GEY
V
L
P
G
P
G
G
---
D
P
I
R
N
P
N
V
L
P
T
G
K
N
I
H
A
L
D
P
Q
S
I
P
T
L
A
A
V
Q
S
A
K
V
V
V
D
R
L
-
L
E
R
Q
R
A
E
N
G
G
N
Y
P
E
T
I
A
S
V
L
W
G
T
D
N
I
K
T
YG
E
S
L
A
Q
I
M
W
--
M
V
G
A
K
P
V
P
D
A
L
-
G
R
V
N
K
I
E
L
V
P
-
L
E
-----
E
L
G
R
P
R
I
D
V
V
V
N
C
S
G
V
F
R
D
L
F
I
N
Q
M
N
L
L
D
Q
A
V
K
L
A
A
------
E
A
D
E
P
------
L
E
M
N
F
V
R
K
H
---
A
L
E
Q
A
E
E
M
G
I
G
V
R
E
A
A
TR
I
F
S
N
A
S
G
S
Y
S
S
N
V
-
N
L
A
V
E
N
SS
W
--
E
D
-
E
--
S
E
L
Q
E
M
Y
L
K
R
K
S
F
A
F
N
S
D
----
N
P
G
M
M
D
Q
N
R
D
M
F
E
R
A
L
K
T
A
D
A
T
F
Q
N
L
D
S
S
E
I
S
L
T
D
V
S
--------
H
Y
F
D
S
D
P
T
K
L
I
S
T
-----
L
R
D
D
G
K
A
P
A
A
Y
I
A
D
T
T
T
ANAQVRT
L
S
E
T
V
R
L
D
A
R
T
K
L
L
N
P
K
W
Y
E
G
M
L
S
H
G
---
Y
E
G
V
R
E
L
S
K
R
L
V
N
T
M
G
W
S
A
T
A
G
A
V
D
N
W
V
Y
E
-----
D
A
N
S
T
F
I
K
D
E
E
M
C
K
R
L
M
D
L
N
P
N
S
F
R
R
M
V
S
T
L
L
E
---
V
N
G
R
G
Y
W
E
T
S
D
E
N
L
E
R
L
Q
E
L
Y
Q
E
V
E
D
R
I
EGV
21
HHSearch
70.64
17%
-58
- C4 -
1E9R
2
?
A:
[49-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
D
A
E
P
R
H
L
L
V
N
G
A
T
G
T
G
----
K
S
V
L
-
L
R
E
L
A
Y
T
G
L
L
----
R
G
D
R
M
V
I
V
D
P
-
N
G
D
M
L
S
K
F
G
----------
R
D
K
D
I
I
L
N
------
P
Y
D
Q
-
R
T
K
G
W
S
F
F
N
E
I
R
N
D
------
Y
D
W
----
Q
R
Y
A
L
S
---
V
V
P
R
G
K
T
-------
D
---------
E
A
E
E
W
A
S
Y
G
R
L
L
-----
L
R
E
T
A
K
---
K
L
A
L
I
G
-------------
T
P
S
M
R
--
E
L
F
H
W
--
T
T
I
A
T
F
D
---------------------------
D
L
R
G
F
L
E
G
T
L
----------------------
A
E
S
L
F
-----
A
G
S
N
E
A
S
K
A
L
T
S
A
R
F
V
L
--------
S
D
K
L
P
E
H
V
T
M
P
D
G
D
F
-
S
I
R
S
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
N
G
G
--------
N
L
F
--
I
T
----
W
R
E
D
M
G
P
A
L
R
P
L
I
S
A
W
-
V
D
-----
V
V
C
T
S
I
L
S
L
P
-------
E
E
P
K
R
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
-
R
S
L
V
V
---
L
--
G
G
-
S
RT
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
---------------
R
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
G
T
--------------------------------------------------------------------------------------------------------------------------
41
Fugue
61.69
13%
-8
* C4 *
1E9R
2
?
A:
[4-436]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Q
G
E
F
G
G
A
P
F
K
R
F
L
R
G
T
R
I
V
S
G
G
K
L
---
K
R
M
T
R
E
K
A
K
Q
V
-
T
V
A
--
G
V
P
M
-------
P
R
D
A
E
P
R
H
L
L
V
N
G
A
---
T
G
T
G
K
S
V
L
L
R
E
L
A
Y
T
G
L
L
R
----
G
D
R
M
V
I
V
D
--
P
N
G
D
M
L
-
S
K
F
G
R
D
K
D
I
-
I
L
N
P
Y
D
Q
R
T
K
G
W
S
F
F
N
E
I
R
N
--
D
Y
D
W
Q
R
Y
A
--
L
S
V
V
P
R
G
K
T
D
E
-------------------
A
--
E
E
W
---
A
S
Y
-------
G
R
L
L
L
R
E
T
A
K
K
L
A
L
I
G
T
P
S
M
R
E
L
F
H
W
T
T
I
A
T
F
------
D
D
L
R
---
G
F
L
E
G
T
L
A
E
S
L
F
A
G
S
N
-
E
A
S
K
A
L
T
S
A
R
F
V
L
S
-
D
K
L
P
E
H
V
-
T
M
P
D
G
D
F
S
I
R
S
W
L
E
D
P
N
-------
G
G
N
--------
L
F
I
--
T
W
----
R
E
D
M
G
-
P
A
L
R
P
L
I
S
A
W
-
V
D
-----
V
V
C
T
S
I
L
S
L
P
E
E
---
P
K
R
----
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
-
R
S
L
V
V
---
L
GG
S
R
-
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
R
---------------
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
GN
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
-------
V
E
G
T
-------------------------------------------------------------------------------------------------------------------------------
43
Fugue
59.50
17%
-21
- C4 -
4MGR
3
GABR_BACSU
A:
[2-469]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
I
T
L
DRSEQ
A
D
Y
I
Y
Q
---
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
----
S
K
R
E
L
--
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
---
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
--
H
P
P
F
-------
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
-------
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
--
A
S
R
S
Y
R
-
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
--
R
P
E
Q
M
I
I
G
AG
T
Q
V
L
M
-
Q
L
L
T
E
L
L
PKE
A
V
Y
A
M
E
EPGY
R
R
M
Y
Q
--
L
L
K
N
A
G
K
Q
V
-------
K
T
I
M
L
D
E
K
G
M
S
I
A
E
I
T
R
Q
Q
P
D
V
L
V
T
T
P
--
S
H
Q
------
F
P
S
G
---
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
-
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
-
E
F
T
Y
D
V
D
-
S
I
P
A
L
Q
S
L
D
R
F
--------------
Q
N
--------
V
I
Y
--
M
G
----
T
F
S
K
S
-
L
L
P
G
L
R
I
S
Y
M
V
L
P
-----
P
E
L
L
R
A
Y
K
Q
R
G
Y
---
D
L
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
-----------------------
S
G
E
Y
Q
K
---
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
-------
R
L
I
T
A
L
E
A
E
F
-
S
G
E
V
T
---
V
--
K
G
-----
A
N
A
G
L
H
F
V
T
---
E
F
D
T
R
RT
E
Q
D
I
L
S
H
A
A
G
L
Q
L
E
I
F
G
--
M
S
R
F
N
L
K
E
N
K
R
Q
T
G
R
P
A
L
I
I
G
F
ARLKEE
D
I
Q
E
G
V
-
Q
R
L
F
K
A
-----
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
55.31
20%
-22
- C4 -
4D2I
2
?
A:
[1-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
I
---------
G
Y
V
I
G
Q
A
T
T
Q
E
A
L
I
L
A
E
R
------
P
V
R
L
G
T
Y
V
V
L
E
Y
D
N
V
K
A
L
G
L
I
T
N
V
T
R
G
--
S
P
L
L
-----------------------
D
D
N
M
N
D
I
E
I
V
Q
R
L
-
K
-
Q
F
N
N
S
I
P
V
Y
T
----
K
A
K
V
K
L
L
C
D
M
N
------
N
H
F
-----
L
--
M
P
D
I
P
P
F
A
G
T
P
--
A
R
E
A
E
D
E
E
--
L
K
S
I
Y
S
Q
D
-
G
Q
I
R
I
GSLIGKN
V
E
V
K
L
N
I
N
S
F
A
R
H
L
A
I
L
A
A
T
G
S
G
----
K
S
N
T
V
A
V
L
S
Q
R
I
---
S
--
E
L
G
G
S
V
L
I
F
D
Y
-
H
G
E
Y
Y
D
S
D
I
K
N
L
N
R
I
----
E
P
K
L
N
P
L
Y
------
M
T
P
R
E
F
S
T
L
-----
L
E
I
R
E
N
A
I
I
Q
Y
R
I
L
R
R
A
F
I
K
V
T
N
G
---
I
R
A
A
L
A
A
G
Q
IPF
S
T
L
---------
N
S
Q
F
Y
E
L
M
A
D
A
L
-----
K
D
E
V
L
N
K
F
E
E
F
M
D
R
Y
S
N
V
I
D
L
T
S
S
D
I
I
E
K
V
K
R
G
KV
N
V
V
S
L
TQ
L
D
E
D
S
M
D
A
V
V
S
H
Y
L
R
R
I
L
D
S
R
K
D
F
K
R
S
K
N
SGL
K
F
P
I
I
A
V
I
E
E
A
H
V
F
------
L
-------
S
K
-
N
E
N
T
L
T
K
Y
W
A
S
R
I
A
R
E
G
R
K
F
G
V
G
L
T
I
V
S
Q
R
P
K
G
----
L
D
E
N
I
L
S
Q
--
M
T
-
N
K
I
-
I
L
K
I
I
E
P
T
D
-
K
K
Y
I
L
-
E
S
S
D
N
--
L
S
E
D
L
A
E
--
Q
L
S
S
L
D
V
G
--
E
A
I
I
I
-
G
K
I
V
K
-------------------
L
PA
V
V
K
---
I
D
M
-------
F
E
G
K
L
L
G
S
D
P
D
M
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
52.20
26%
23
- C3 -
1GL6
3
?
A:
[279-401]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
---
G
--
G
S
R
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
----------------
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
G
T
--------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.98
26%
27
- C3 -
1GL7
1
?
A:
[280-402]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
---
G
--
G
S
R
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
------------------
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.23
26%
22
- C3 -
1E9S
-
?
A:
[350-472]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
---
G
--
G
S
R
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
R
Y
S
K
-----------
R
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
G
T
I
-------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.99
26%
24
- C3 -
1GKI
1
?
A:
[280-402]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
---
G
--
G
S
R
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
----------------
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
G
T
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.79
26%
35
- C3 -
1E9R
-
?
A:
[280-402]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
W
L
F
I
D
E
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
---
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-------
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
---
G
--
G
S
R
T
--
D
P
K
T
N
E
D
M
S
L
---
S
L
G
E
H
----
E
V
E
R
D
---------------
R
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
--------
N
L
P
D
L
T
-
A
Y
V
G
F
A
-----
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
-------
R
Q
P
A
F
V
E
G
T
--------------------------------------------------------------------------------------------------------------------------
47
Fugue
45.35
9%
-28
- C4 -
3F4M
1
TP8L2_HUMAN
A:
[8-161]
-------------------------------------------------------------------
I
D
--
E
T
S
S
E
-----
V
L
D
--
E
L
Y
R
V
S
K
E
Y
T
H
S
R
-
P
Q
A
Q
R
V
I
K
D
L
I
K
V
A
-----------
I
K
V
A
V
L
-----
H
R
N
G
S
F
G
P
S
E
L
A
L
A
T
---
R
F
R
Q
K
L
R
Q
G
--------
A
M
T
A
L
S
F
G
E
V
--------------
D
F
T
F
E
A
A
V
L
A
------------------------------
G
L
L
T
E
C
R
D
V
L
L
----
E
L
V
E
H
H
L
T
P
K
S
H
G
R
I
R
H
V
F
D
H
F
S
D
P
G
L
--
L
T
A
L
Y
G
P
D
F
T
Q
H
L
G
K
I
C
D
G
L
R
K
L
L
---
D
E
G
K
-------
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
43.08
16%
67
- C4 -
1YOZ
-
Y941_ARCFU
A:
[9-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
H
M
L
Y
I
N
---
S
F
L
D
R
M
G
E
I
I
R
G
E
K
S
-------
V
E
--
E
A
D
K
L
--
L
D
Q
K
N
I
F
E
M
F
R
S
D
C
E
E
I
L
N
L
Y
K
S
G
K
A
E
K
E
---
E
V
Q
R
N
F
Y
L
L
K
T
Y
V
V
S
Q
L
S
I
H
F
-------
E
R
L
K
E
F
A
E
----------
S
K
G
E
K
K
L
D
P
E
V
I
N
E
I
A
L
Y
----
I
D
R
V
E
K
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
42.03
12%
4
- C4 -
4U0O
4
LIPA2_THEEB
B:
[8-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
W
L
R
I
S
T
---
V
Q
R
L
-------
V
R
Q
Y
G
------------
I
H
T
I
C
E
---------
E
G
R
C
P
N
R
G
E
C
Y
G
Q
-
K
T
A
-------
T
F
L
L
L
G
P
T
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
A
P
A
A
V
DP
E
E
P
T
-----------------------
K
I
A
A
A
V
A
T
L
G
L
R
Y
-
V
-
V
L
T
S
V
A
R
D
D
L
P
---
D
Q
G
A
G
Q
F
V
A
T
M
------
A
A
I
R
Q
R
C
-
P
--
G
T
E
I
E
V
L
S
P
D
F
RM
D
R
G
R
L
S
Q
R
D
C
I
A
Q
I
V
A
A
Q
-
P
A
C
Y
N
--------------
H
N
L
E
T
V
R
R
L
Q
G
P
V
R
R
G
ATYE
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
--
P
T
K
S
G
L
M
L
G
L
G
E
T
E
A
E
I
I
E
T
L
K
D
L
R
R
V
----
G
C
D
R
L
T
L
G
QYLPPS
L
S
H
L
P
V
V
K
Y
W
T
P
E
E
F
N
T
L
G
N
I
A
R
E
L
G
F
S
H
V
R
S
G
P
L
V
R
S
---
S
Y
H
A
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
37.75
28%
151
- C3 -
3WAN
1
ATG13_HUMAN (first)
A:
[20-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
F
K
Q
R
--
R
S
F
A
-----------------------
D
R
C
K
E
V
Q
Q
I
R
D
Q
H
P
S
-
K
I
P
V
I
I
E
R
Y
K
G
---
E
K
Q
L
P
V
L
D
K
T
K
F
L
V
P
DH
V
N
M
S
E
L
V
K
I
--
I
R
R
R
L
Q
L
N
P
T
Q
--
A
F
F
L
L
V
N
Q
H
S
M
V
S
V
S
T
P
I
-
A
D
I
Y
E
--------------
Q
E
K
D
E
D
G
F
L
Y
M
V
Y
A
S
Q
----
E
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
37.53
13%
74
- C3 -
2IUT
-
FTSK_PSEAE
A:
[342-417]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
---
A
T
Q
R
P
S
V
--
D
V
I
-----------
T
G
L
I
K
A
N
I
-
P
T
R
I
A
---
F
--
Q
V
-
S
--
S
K
I
D
S
R
T
I
L
D
---
Q
G
G
A
E
----
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
--
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
--------
E
A
W
K
L
R
-
G
A
P
D
Y
I
-----
E
D
I
L
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
37.34
23%
74
- C3 -
4OXR
1
?
A:
[45-171]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
K
P
K
D
V
Q
A
L
T
D
A
D
V
I
I
Y
N
G
F
N
L
E
S
---
G
N
G
W
F
E
K
A
L
K
Q
A
N
K
S
I
K
D
D
S
V
I
Q
A
-----
S
K
N
V
K
P
---
I
Y
L
K
Q
G
E
K
S
E
H
N
I
D
P
H
A
W
----------------
L
S
L
G
N
G
I
E
Y
V
K
T
I
K
S
A
L
E
N
A
D
K
T
H
A
K
D
Y
---
D
K
Q
G
T
E
Y
L
S
K
L
E
K
L
N
--
K
E
S
K
-------
D
K
F
N
D
I
P
K
E
K
R
V
M
I
T
S
E
G
A
F
K
Y
F
A
Q
Q
F
D
V
K
P
G
Y
I
W
E
----
I
N
T
E
N
Q
G
T
--
P
E
Q
M
K
Q
-
A
V
D
F
V
K
E
N
H
-
I
K
N
L
L
L
E
T
S
V
S
D
K
S
M
K
S
L
G
E
--
E
T
G
A
K
I
Y
G
--
T
V
Y
T
D
-
S
I
G
K
K
-------------------
G
--
S
D
G
---
D
S
Y
-------
Y
K
M
M
E
S
N
I
K
T
I
H
E
S
M
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
37.26
28%
141
- C3 -
3WAL
1
MLP3A_HUMAN
A:
[9-103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
F
K
Q
R
--
R
S
F
A
-----------------------
D
R
C
K
E
V
Q
Q
I
R
D
Q
H
-
P
S
K
I
P
V
I
I
E
R
Y
K
G
---
E
K
Q
L
P
V
L
D
K
T
K
FLVPDH
V
N
M
S
E
L
V
K
I
--
I
R
R
R
L
Q
L
N
P
T
Q
--
A
F
F
L
L
V
N
Q
H
S
M
V
S
V
S
T
P
I
-
A
D
I
Y
E
--------------
Q
E
K
D
E
D
G
F
L
Y
M
V
Y
A
S
Q
----
E
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
36.02
16%
68
- C3 -
2YKG
2
A:
[28-96]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
N
T
I
I
C
A
P
T
G
C
G
----
K
T
F
V
S
L
L
I
C
E
H
H
L
K
K
F
PQ
G
Q
K
G
K
V
V
F
F
A
N
-
Q
I
P
V
Y
E
Q
N
K
S
V
F
S
K
Y
F
ERH
G
Y
R
V
T
G
I
S
------
G
A
T
A
E
N
V
P
V
E
Q
I
V
E
N
N
D
I
I
I
L
T
P
Q
I
L
V
N
N
L
K
K
G
T
I
P
S
L
---
S
I
F
T
L
M
I
F
D
---
E
C
H
---------
N
T
S
K
Q
H
P
Y
N
M
I
M
-----
F
N
Y
L
D
Q
---
K
L
G
G
S
S
G
P
L
P
Q
V
I
G
L
T
A
S
V
G
V
G
D
A
--
K
T
T
D
E
--
A
L
D
Y
I
C
K
L
C
A
S
L
D
A
S
V
I
A
T
V
K
H
N
L
E
E
L
E
Q
---
V
V
Y
K
P
Q
K
F
F
R
K
V
E
S
R
--
I
S
D
K
-------
F
K
Y
I
I
A
Q
L
M
R
D
T
E
S
L
A
K
R
I
C
K
D
L
E
N
L
S
Q
I
Q
N
R
E
F
G
T
----
Q
K
Y
E
Q
W
I
V
--
T
V
Q
K
A
C
-
M
V
D
E
E
S
R
I
C
-
K
A
L
F
L
Y
T
S
H
L
R
K
Y
N
D
A
L
I
I
S
--
E
H
A
R
M
K
D
A
--
L
D
Y
L
K
-
D
F
F
S
N
-------------------
V
--
R
A
A
---
G
F
D
-------
E
I
E
Q
D
L
T
Q
R
F
E
E
K
L
Q
E
L
E
S
V
S
R
D
P
S
N
E
N
P
K
L
E
------
D
L
C
F
---
I
L
Q
E
E
Y
H
L
N
P
E
T
I
T
I
L
-
F
V
K
T
R
A
L
V
D
A
L
K
N
W
-
I
E
G
N
P
K
L
-
S
F
L
K
P
G
I
D
H
N
I
L
I
A
T
S
V
A
D
E
G
A
Q
C
N
L
V
--------
I
L
Y
--
E
Y
----
V
V
I
K
M
-
R
G
S
K
C
F
L
L
T
S
-
N
A
-----
G
V
I
E
K
E
Q
I
N
M
Y
K
---
E
K
M
M
N
D
S
I
L
R
L
Q
T
W
D
E
A
V
F
R
E
------
K
I
L
H
I
Q
T
H
E
K
F
I
R
D
S
Q
E
K
P
K
---
P
V
P
D
K
E
N
K
K
L
L
C
R
K
-------
C
K
A
L
A
C
Y
T
A
D
-
V
R
V
I
E
---
D
--
C
H
-
Y
--
T
V
L
G
D
A
F
K
E
C
---
F
V
S
R
P
----
H
P
K
P
K
Q
F
S
S
F
E
K
R
A
K
--
I
F
C
A
R
Q
N
C
S
H
D
W
G
I
H
V
K
Y
K
T
--------
F
E
I
P
V
I
-
K
I
E
S
F
V
-----
V
E
D
I
A
T
G
V
Q
T
L
Y
S
K
W
K
D
-------
F
H
F
E
K
I
P
F
D
P
A
E
-----------------------------------------------------------------------------------------------------------------------
26
HHSearch
35.35
13%
84
- C3 -
2IUS
-
FTSK_ECOLI
A:
[1113-1188]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
---
A
T
Q
R
P
S
V
D
--
V
I
T
-----------
G
L
I
K
A
N
I
-
P
T
R
I
A
---
F
--
T
V
-
S
--
S
K
I
D
S
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------