@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0410: (2015-11-30 )
MTIFDERELKERFTHENRVSFYEFVAKYDAQMVPVMKAKGYRCIHSMERTVVFTFGEFTIRRRRWQKGEHWVVPVDEKLGLKKNVRYSLEFMYQIASLATMMPYEKVIKVVQMMYCIVITKPTVVKAVKISRELLKEKEAYRFFDEDIPVDKEPVDMIYLEGDGVMVKAREEGLDNRNVDLSHFVVHTGSQKVGSNRFVLQNKKEFVSLDNRQTRQKILDYLYNHFYIAPNTLLITNSDGGHGYTPYVFKEIAKALKVKQHEHFWDRYHVNEKIKSFFKLYPVELMTGAFQSIKQHDKEKLRTVLDTTEALILMEEEMEGFNQFKRKLLNNFQYTKSAELRGFSRAGIGVMESQHRKITYRMKKRGMYWTIQGAETMSQLIVLSYEGQLRDLFFGSWREDYQKYQELENLSAGKIKHEQNKINKRYDLQTLGRLRYGRHRNL
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------.........10........20.....---...30....------..------..40.-......-------.50........60----...-------------------..----...70.....---...80......--..90........-100-.---------...--...------..110------..---.....120.....-...130--.--...-...140--....-...--150........160..---.....170.......180.......--190........200.......210...-------.---.....220--........230.........240......-.-------250.....----..260------......------.270..-.....280-...-.....290-----.....----...300--------------.......310..--------.---....320.......330-------.......-..-340.-...-----...350.--------......360-........370.-----....---..380....-...390.-----......400.-----......410.......420.....--------..430.......440-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------MTIF
D
E
R
E
L
K
E
RFTHEN
R
V
S
F
Y
E
F
V
A
---
K
YDAQM
V
P
V
------MK------AKG
Y
R
-
C
I
H
SME-------
R
T
V
V
F
T
FGE
F
T
I
R
----
R
R
R-------------------WQ----KGE
H
W
V
V
P
V
D
---
E
KLGLKKN
V
R
Y
--
S
L
E
F
M
Y
Q
I
A
S
L
A
-T---M---------M
P
Y
--
E
K
V
------
I
K
V
V
Q
------
M
M
---
Y
C
I
V
IT-KP
T
V
V
K
-
A
V
K
I
S
R
--
E
--
L
L
K
-
E
K
E
A
Y
R
--
F
FDE-DIP--V-DKEP
V
D
M
I
Y
LEGD
G
---
V
M
V
K
A
R
EEGLDNRNVD
L
S
H
F
V
V
HTG--SQ-KVGSN
R
F
V
LQN
K
K
E
F
V
SLD--
N
R
Q
-------
T
---
R
Q
K
I
L
D
Y
---
L
Y
N
H
F
Y
IAP--
N
T
L
L
I
TNSDGGHGYT
P
Y
V
-
F
-------
K
E
I
A
K
A
L
K
----
V
K
Q
H
E
------
H
F
W
D
R
Y------HV
N
E
K
I
-
K
S
F
F
K
LY--
P
V
E
-
L
M
T
G
A
F
Q
------
S
I
K
Q
H
----
D
K
E
K
L
R
--------------
T
V
L
DT
T
E
A
L
I
L
M
--------
E
---
E
E
M
E
G
F
N
Q
F
K
R
K
L
L
N
---------NFQYTKS-AE-LRGF-SRA-----GIGVMES--------QHR
K
I
T
Y
R
--MKKRG
M
Y
W
T
IQ
G
-----
A
E
T
M
---
S
Q
L
I
V
L
SYE-G
Q
L
R
D
L
F
-----
F
G
S
W
R
E
D
Y
Q
K
-----
Y
Q
E
L
E
NLSAGKI
K
H
E
Q
N
K
INKRY
D
--------
L
Q
T
L
G
R
L
RYGRHRNL-----------------
24
Fugue
80.97
14%
-22
- C3 -
1E6V
3
?
B:
[7-442]
--------------------------------------------------------------------------------------------------------------------------------------
D
T
V
D
L
Y
D
D
R
G
---
N
C
V
A
E
E
V
P
I
------
E
V
LSPMRN
E
A
I
Q
S
-
I
V
N
D
I
K
-------
R
T
V
A
V
D
L
E
G
I
E
N
A
----
L
Q
N
ATVGGKGMKIPGR
E
M
D
V
D
I
V
D
----
N
A
E
A
I
A
D
E
I
E
---
K
M
I
R
V
Y
Q
D
D
D
T
--
N
V
E
P
M
Y
D
G
K
R
L
L
-
V
---
Q
---------
L
P
S
--
E
R
V
------
K
V
M
A
D
------
P
Y
---
S
G
T
L
Q
A
-
G
M
A
V
V
H
-
A
I
I
D
V
C
EV
D
--
M
W
D
-
A
N
M
V
K
A
--
A
V
F
G
-
R
Y
P
--
Q
-
T
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D
Y
F
G
G
N
V
A
S
M
L
D
---
V
P
M
K
Q
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G
V
G
Y
A
L
R
N
I
M
V
N
H
I
V
A
A
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KN
T
M
-
Q
A
V
C
L
A
A
T
L
Q
Q
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A
M
F
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M
G
D
AL
G
P
F
-------
E
---
R
L
H
L
L
G
Y
---
A
Y
Q
G
L
N
A
D
N
--
M
V
Y
D
I
V
K
K
H
G
K
E
G
T
V
G
T
V
-
V
-------
R
E
V
V
E
R
A
L
E
D
GV
I
E
V
K
E
------
E
L
P
-
S
F
------
K
V
Y
K
A
N
-
D
--
M
D
L
W
--
N
A
Y
-
A
A
A
G
L
V
A
------
A
V
M
V
N
----
Q
G
A
A
-
R
--------------
A
A
Q
G
V
S
A
T
I
L
Y
Y
--------
N
---
D
L
L
E
Y
E
T
G
L
P
G
-
V
D
F
---------
G
R
A
E
G
T
A
-
V
G
-
F
S
F
F
-
S
H
S
IY
G
G
G
G
P
G
I
F
H
G
--------
N
H
I
-
V
T
R
H
--
S
K
--
G
F
A
I
P
P
V
A
-----
A
A
M
A
---
L
D
A
G
T
Q
M
F
S
-
P
E
V
T
S
K
L
-----
I
G
D
V
F
G
E
I
D
E
-----
F
R
E
P
M
K
Y
I
T
E
A
A
A
E
E
A
K
-----------------------------------------------
28
Fugue
77.21
14%
-25
* C3 *
1HBN
5
MCRB_METTM
B:
[1-442]
----------------------------------------------------------------------------------------------------------------------------------
A
K
F
E
D
K
V
D
L
Y
D
D
R
G
---
N
L
V
E
E
Q
V
P
L
------
E
A
LSPLRN
P
A
I
K
S
-
I
V
Q
G
I
K
-------
R
T
V
A
V
N
L
E
G
I
E
N
A
----
L
K
T
AKVGGPA
C
K
I
M
GR
E
L
D
L
DI
V
G
----
N
A
E
S
I
A
A
A
A
K
---
E
M
I
Q
V
T
E
D
D
D
T
--
N
V
E
L
L
G
G
G
K
R
A
L
-
V
---
Q
---------
V
P
S
--
A
R
F
------
D
V
A
A
E
------
Y
S
---
A
A
P
L
V
T
-
A
T
A
F
V
Q
-
A
I
I
N
E
F
--
D
VS
M
Y
D
-
A
N
M
V
K
A
--
A
V
L
G
-
R
Y
P
--
Q
-
S
V
E
Y
M
G
A
N
I
A
T
M
L
D
---
I
P
Q
K
L
E
G
P
G
Y
A
L
R
N
I
M
V
N
H
V
V
A
A
T
L
KN
T
L
-
Q
A
A
A
L
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T
I
L
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A
M
F
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M
G
D
AV
G
A
F
-------
E
---
R
M
H
L
L
G
L
---
A
Y
Q
G
M
N
A
D
N
--
L
V
F
D
L
V
K
A
N
G
K
E
G
T
V
G
S
V
-
I
-------
A
D
L
V
E
R
A
L
E
D
G-
V
I
K
V
E
------
K
E
L
T
D
Y
------
K
V
Y
G
T
---
D
D
L
A
M
W
--
N
A
Y
-
A
A
A
G
L
M
A
------
A
T
M
V
N
----
Q
G
A
A
-
R
--------------
A
A
Q
G
V
S
S
T
L
L
Y
Y
--------
N
---
D
L
I
E
F
E
T
G
L
P
-
S
V
D
F
---------
G
K
V
E
G
T
A
-
V
G
-
F
S
F
F
-
S
H
S
IYGGG
G
P
G
I
F
N
G
--------
N
H
--
I
V
T
R
--
H
S
K
G
F
A
I
P
C
V
A
A
-----
A
M
A
L
DAG
T
Q
M
F
S
P
E
A
T
-
S
G
L
I
K
E
V
-----
F
S
Q
----
V
D
E
-----
F
R
E
P
L
K
Y
V
V
E
A
A
A
E
I
K
N
E
I
---------------------------------------------
27
Fugue
59.91
17%
22
- C3 -
2CSB
-
?
A:
[3-519]
----------------------------------------------------------------------------------------------------------------------
L
V
Y
D
A
E
F
V
G
S
E
R
E
F
E
E
E
R
E
T
F
L
K
G
V
K
---
A
Y
D
G
V
L
A
T
R
Y
L
M
E
RS
S
S
------
A
K
N
D
E
-
E
L
L
E
L
H
-------
Q
N
F
I
L
L
T
G
S
Y
A
C
S
IDPT
E
D
R
-------------------
Y
Q
NVIV
R
G
V
N
F
D
E
R
V
Q
---
R
L
S
T
G
G
S
P
A
R
Y
--
A
I
V
Y
R
R
G
W
R
A
I
A
-
K
---
A
---------
L
D
I
--
D
E
E
DVPAIE
V
R
A
V
K
RNPLQ
P
A
L
---
Y
R
I
L
V
R
-
Y
G
R
V
D
L
M
P
V
T
V
D
E
--
V
--
P
P
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M
A
G
E
F
E
R
--
L
I
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R
Y
D
V
P
--
I
D
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K
E
E
R
I
L
E
I
L
R
E
N
P
WTP
H
D
E
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A
R
R
L
G
L
S
V
S
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V
E
G
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K
D
P
E
S
S
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--
I
Y
-
S
L
W
S
R
V
V
V
N
I
E
Y
D
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R
T
A
K
R
--
H
V
K
-------
R
---
R
D
R
L
L
E
E
---
L
Y
E
H
L
E
E
L
S
--
E
R
Y
L
R
H
P
L
T
R
R
W
I
V
E
H
K
R
D
I
M
------
R
R
Y
L
E
Q
R
I
----
V
E
C
A
L
------
K
L
Q
D
R
Y
------
G
I
R
E
D
V
A
L
C
L
A
R
A
F
DG
S
I
S
M
I
A
T
T
P
Y
R
------
T
L
K
D
V
C
PDL
T
L
E
E
A
K
--------------
S
V
N
R
T
L
A
T
L
I
D
E
HGLS
P
D
A
A
D
---
E
L
I
E
H
F
E
S
I
A
G
I
L
A
T
---------
D
L
E
E
I
E
R
M
Y
E
-
E
G
R
L
S
E
E
A
-----
Y
R
A
A
V
E
I
--------
Q
L
A
E
L
T
K
K
EG
V
G
R
K
T
A
E
R
L
L
R
A
-----
F
G
N
P
---
E
R
V
K
Q
L
A
R
E
-
F
E
I
E
K
L
A
SV---
E
G
V
G
E
R
V
L
R
S
L
VPG-
Y
A
S
L
I
S
I
R
-
G
I
D
R
E
R
A
E
R
L
L
K
K
Y
G
----------
G
Y
S
K
V
R
E
A
G
V
E
E
L
R
E
D
GLT
D
A
Q
I
R
E
L
K
GLK
30
Fugue
58.19
19%
-15
- C4 -
4RHJ
1
?
A:
[19-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
F
S
--
K
--
F
L
M
-
N
V
K
G
V
T
--
P
R
G
S
-
D
W
A
--
N
-
R
L
G
P
V
A
L
F
G
Y
G
A
G
M
---
P
R
R
A
P
L
L
D
F
F
L
Q
S
P
R
D
C
D
H
Y
A
E
L
T
I
--
H
D
-
K
-
G
P
I
E
C
P
P
E
T
V
M
F
M
P
V
L
N
--
C
G
Q
MLDEAAG
T
---
E
T
P
T
S
D
E
---
W
Y
L
G
S
L
E
A
S
--
T
E
L
L
------
E
K
G
Y
V
P
V
S
-
V
G
GDG
S
A
T
L
S
M
V
E
A
Y
K
----
R
L
F
P
S
D
D
I
V
I
V
H
F
S
A
R
P
------
S
V
S
D
P
R
-
S
P
L
R
V
L
L
--
D
K
G
-
L
L
K
G
V
V
S
V
GNRQV
S
S
E
D
R
----
K
V
R
K
L
H
K
M
F
Y
M
D
MRDIRND
Y
P
V
F
I
S
I
D
A
S
V
L
D
--------
P
---
A
F
A
P
A
V
D
S
P
V
A
G
G
L
S
---------
T
R
D
L
L
H
I
-
M
N
G
I
R
G
P
-
K
V
V
-----
G
I
D
V
Y
G
Y
--------
N
P
D
L
D
V
Y
R
--
K
D
N
V
G
-------------
L
T
A
---
I
A
L
S
K
I
I
K
E
-
G
I
L
K
---------------------------------------------------------------------------------------
31
Fugue
56.36
16%
-15
- C2 -
4XZZ
2
?
A:
[24-339]
----------------------------------------------------------------------------------------------------------------------------
L
N
A
S
D
R
L
L
E
I
M
R
L
Y
Q
K
Q
G
L
E
---
M
V
G
Q
K
L
D
S
Y
------
L
A
------
D
K
S
F
W
-
A
E
E
L
Q
N
-------
K
D
T
D
F
G
Y
Y
Q
-------------------------------------
N
K
Q
F
L
F
V
A
N
KSK
P
S
L
E
F
Y
E
I
E
N
N
--
M
L
K
K
I
N
S
S
K
A
L
V
-
G
---
S
---------
K
K
G
--
D
K
T
------
L
E
G
------------------
D
-
L
A
T
P
I
G
-
V
Y
R
I
T
Q
--
K
--
L
E
R
-
L
D
Q
Y
Y
G
V
L
A
F
V
T
-
N
Y
P
N
L
Y
-
D
T
L
K
K
R
----
T
G
H
G
---
I
W
V
H
G
M
P
L
N
-
G
D
R
N
E
L
N
T
K
G
C
I
A
I
E
--
N
P
-
L
L
S
S
Y
D
K
V
L
K
G
E
K
--------------------------------------------
A
F
L
I
T
Y
E
D
K
F
F
P
S
T
K
E
E
-
L
-------
S
M
I
L
S
S
L
F
------
Q
W
K
------
E
A
W
A
R
G
------
D
----
F
-
E
R
Y
M
R
F
Y
--
N
P
N
-
F
T
R
--------------
Y
----
D
G
M
K
------------------------------------------
F
N
A
F
K
E
Y
K
K
R
V
F
A
---------
K
-----------------------------
N
--------
E
K
K
N
I
A
F
S
---------------------------
S
I
N
V
I
P
Y
P
N
S
Q
N
K
R
L
F
-----
Y
V
V
F
D
Q
D
Y
K
A
-----
Y
Q
H
------
N
K
L
S
Y
S
S
N
S
Q
K
E
L
Y
I
--------
E
I
E
N
N
Q
V
S
I
I
M
E
K
-------------------
29
Fugue
52.41
15%
-13
* C4 *
4ZCF
2
?
C:
[6-810]
TLEKNL
P
H
Q
K
A
G
V
D
A
V
M
N
V
F
VS
A
T
P
H
L
T
DN
V
A
V
R
L
L
ANPELKLS
E
Q
Q
Y
Y
N
N
I
K
N
V
Q
A
F
N
GIAHSKDNHNAKSN
I
I
D
V
S
M
E
T
GTG
K
T
Y
T
Y
I
K
T
I
F
D
L
N
K
S
FGIN
K
F
I
I
I
V
PT
L
S
I
K
A
G
T
V
N
F
L
K
S
D
A
L
K
E
H
F
R
D
D
Y
K
R
E
L
R
T
Y
V
V
E
S
Q
K
M
P
Q
A
I
H
D
F
------
V
E
------
A
S
N
F
K
K
Y
I
H
V
L
V
I
------
N
S
G
M
I
N
S
K
S
L
T
D
T
----
Y
D
T
-------------------
G
L
----
L
D
N
Q
F
N
T
P
V
D
---
A
L
R
A
V
K
P
F
I
I
I
D
E
P
H
R
F
P
T
G
K
K
T
W
E
-
N
---
I
---------
E
K
F
NA
Q
Y
I
------
I
R
Y
G
A
------
T
F
SEG
Y
K
N
L
V
Y
-
R
L
T
A
V
D
-
A
F
N
--
D
--
D
--
L
V
K
-
G
I
D
A
Y
I
--
E
D
N
A
-
N
L
K
--
F
-
V
K
D
G
K
E
A
T
F
F
K
L
A
K
---
S
L
S
K
T
H
S
A
I
H
D
L
T
L
D
A
L
N
T
A
V
L
S
N
G
--
I
E
L
K
I
G
S
S
I
N
P
Y
S
Y
D
Q
T
L
A
D
N
M
--
M
R
K
-------
A
---
V
K
E
H
F
K
L
E
K
E
L
L
T
Q
P
R
I
K
P
--
L
T
L
F
F
I
D
-
D
L
K
T
K
F
E
E
Y
V
-
L
-------
A
E
A
N
E
L
L
Y
----
K
N
Y
L
E
------
K
T
V
T
N
I
S
SVHGG
Y
I
E
Q
E
I
-
N
E
I
L
H
D
K
--
E
L
L
-
L
S
L
D
N
P
R
------
R
-
F
I
F
----
S
K
W
T
L
R
--------------
E
G
W
D
N
P
N
V
F
Q
I
C
--------
K
LRS
S
K
L
Q
E
V
G
R
G
L
R
L
P
V
N
EYMCRVKN
F
T
L
K
Y
Y
V
D
-
F
T
-
E
K
D
F
-
V
D
S
-----
L
V
K
E
V
N
E
S
SPSKFTQ
E
L
K
E
Q
I
D
N
--
F
K
D
S
D
A
Y
S
R
L
K
S
ELK
E
L
W
D
L
I
---
N
Q
K
A
V
I
E
Y
K
-
I
N
S
E
S
E
F
-----
L
S
I
F
K
S
F
M
L
E
E
TERS
Y
R
E
F
L
D
N
L
S
Q
T
I
F
V
K
H
G
T
L
H
K
V
F
C
D
IKDTILN
I
Q
T
I
R
K
I
K
S
G
F
S
K
Y
L
L
N
N
SF
S
L
G
Y
NL------
15
HHSearch
48.00
20%
-72
- C5 -
2COB
-
A:
[12-57]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Y
--
N
S
E
I
L
E
E
A
I
S
V
V
-
M
S
G-
K
---------
M
S
V
--
S
K
A
------
Q
S
I
Y
---------------
G
I
P
-
H
S
T
L
E
Y
-
K
V
K
E
R
L
--
G
--
T
L
K
-
N
P
P
K
K
K
--
M
K
L
M
-
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
44.34
15%
-82
- C5 -
2ESN
-
?
A:
[7-52]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
--
D
L
N
L
L
L
V
F
D
A
L
Y
-
R
---
H
---------
R
N
V
--
G
T
A
------
A
S
E
L
---------------
A
I
S
-
A
S
A
F
S
H
-
A
L
G
R
L
R
--
Q
--
G
L
D
-
D
E
L
F
L
R
--
Q
G
N
R
-
M
Q
P
--
T
-
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
---
R
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
Q
R
T
F
V
F
A
--
A
T
-
D
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
--
P
G
V
-------
R
---
L
R
L
V
N
A
E
---
R
K
L
S
V
E
A
L
A
--
S
G
R
I
D
F
A
L
G
Y
D
E
E
H
E
R
L
P
-
E
-------
G
I
Q
A
H
D
W
F
----
A
D
R
Y
V
------
V
V
A
R
R
D
------
H
P
R
L
A
G
-
A
P
T
L
E
G
Y
--
L
A
E
-
R
H
A
V
V
T
P
------
W
N
E
D
S
----
G
V
I
D
R
L
--------------
L
A
R
S
G
L
R
R
E
V
A
V
--------
Q
---
L
P
T
V
L
A
A
L
F
L
A
G
S
T
D
---------
F
L
L
T
A
P
R
-
H
A
-
A
R
A
L
-
A
E
A
-----
A
G
L
A
L
Y
P
--------
A
P
F
D
I
P
P
Y
--
V
L
R
L
Y
S
H
V
Q
G
R
D
-----
A
H
A
W
---
M
I
G
Q
L
K
G
L
D
--------------------------------------------------------------------------------------------
12
HHSearch
44.27
7%
-73
- C5 -
1U78
-
TC3A_CAEEL
A:
[5-47]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
--
S
D
T
E
R
A
Q
L
D
V
M
K
-
L
---
L
N--------
V
S
L
--
H
E
M
------
S
R
K
I
---------------
S
R
S
-
R
H
C
I
R
V
-
Y
L
K
D
P
V
--
S
--
Y
G
T
-
S
K
R
A
P
R
--
R
K
A
L
-
S
V
R
--
D
-
E
R
N
V
I
R
A
A
S
N
S
C
K
T
---
A
R
D
I
R
N
E
L
Q
L
S
A
S
K
R
T
I
L
N
V
I
K
R
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
43.83
11%
-77
- C5 -
1PDN
2
PRD_DROME
C:
[12-59]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
N
G
R
P
L
--
P
N
N
I
R
L
K
I
V
E
M
A
-
A
---
D
G--------
I
R
P
--
C
V
I
------
S
R
Q
L
---------------
R
V
S
-
H
G
C
V
S
K
-
I
L
N
R
Y
Q
--
E
--
T
G
S
-
I
R
P
G
V
I
--
G
G
S
K
-
P
R
I
--
A
-
T
P
E
I
E
N
R
I
E
E
Y
K
R
S
---
S
P
G
M
F
S
W
E
I
R
E
K
L
I
R
E
G
V
C
D
R
S
T
A
P
--
S
V
-
S
A
I
S
R
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
43.39
11%
-74
- C5 -
1HLV
2
CENPB_HUMAN
A:
[5-52]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
Q
L
--
T
F
R
E
K
S
R
I
I
Q
E
V
-
E
E
N
P
D
---------
L
R
K
--
G
E
I
------
A
R
R
F
---------------
N
I
P
-
P
S
T
L
S
T
-
I
L
K
N
K
R
--
A
--
I
L
A
-
S
E
R
K
Y
G
--
V
A
S
T
-
C
R
K
--
T
-
N
K
L
S
P
Y
D
K
L
E
G
L
L
I
---
A
W
F
Q
Q
I
R
A
A
G
L
P
V
K
G
I
I
L
K
E
K
A
L
R
I
--
A
E
-
E
L
G
M
D
D
F
T
A
S
N
G
W
L
D
R
F
R
R
--
R
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
43.12
13%
-73
- C5 -
1K78
-
PAX5_HUMAN
A:
[27-74]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
G
R
P
L
--
P
D
V
V
R
Q
R
I
V
E
L
A
-
H
---
Q
G--------
V
R
P
--
C
D
I
------
S
R
Q
L
---------------
R
V
S
-
H
G
C
V
S
K
-
I
L
G
R
Y
Y
--
E
--
T
G
S
-
I
K
P
G
V
I
--
G
G
S
K
-
P
K
V
--
A
-
T
P
K
V
V
E
K
I
A
E
Y
K
R
Q
---
N
P
T
M
F
A
W
E
I
R
D
R
L
L
A
E
R
V
C
D
N
D
T
V
P
--
S
V
-
S
S
I
N
R
I
I
R
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
41.04
14%
-47
- C5 -
2RN7
-
?
A:
[5-56]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
--
S
P
E
V
R
Q
R
A
V
R
M
V
-
L
---
E
S
Q
G
E
Y
DS
Q
W
A
T
I
--
C
S
I
------
A
P
K
I
---------------
G
C
T
-
P
E
T
L
R
V
-
W
V
R
Q
H
E
--
R
--
D
T
G
-
G
D
D
G
G
L
--
T
T
A
E
-
R
Q
R
--
L
-
K
E
P
E
R
E
N
R
E
L
R
R
S
N
---
D
I
L
R
L
A
S
A
Y
F
A
K
A
E
F
D
R
L
W
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
40.12
17%
-41
- C5 -
2LVS
-
?
A:
[60-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
--
T
E
E
E
L
A
T
I
R
E
L
Y
-
L
K--
G
---------
A
T
V
--
Y
E
I
------
A
R
Q
L
---------------
G
R
P
-
E
S
T
I
Y
Y
-
A
L
K
K
L
G
--
L
--
K
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
40.00
16%
-28
- C5 -
2JN6
-
?
A:
[5-50]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
--
S
E
E
F
K
R
D
A
V
A
L
Y
-
E
N
SD
G
---------
A
S
L
--
Q
Q
I
------
A
N
D
L
---------------
G
I
N
-
R
V
T
L
K
N
-
W
I
I
K
Y
G
--
S
--
N
H
N
-
V
Q
G
T
T
P
--
S
A
A
V
-
S
E
A
--
E
-
Q
I
R
Q
L
K
K
E
N
A
L
Q
R
A
---
R
T
R
H
P
A
E
S
C
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.86
11%
6
* C5 *
2LFW
-
?
A:
[93-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
--
T
P
L
S
R
Q
A
L
L
L
T
A
M
E
---
G
---------
F
S
P
--
E
D
A
------
A
Y
L
I
---------------
E
V
D
-
T
S
E
V
E
T
-
L
V
T
E
A
L
--
A
--
E
I
E
-
K
Q
T
R
A
L
--
E
L
V
P
-
R
G
S
--
H
-
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
HHSearch
38.17
2%
-35
- C5 -
2JRT
-
?
A:
[29-76]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
R
W
--
V
A
S
R
K
A
A
V
V
K
A
V
-
I
---
H
GL-------
I
T
E
--
R
E
A
------
L
D
R
Y
---------------
S
L
S
-
E
E
E
F
A
L
-
W
R
S
A
V
A
--
A
--
H
G
E
-
K
A
L
K
V
T
--
M
I
Q
K
-
Y
R
Q
--
L
-
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
38.15
17%
6
- C3 -
1HIW
2
POL_HV1N5
A:
[8-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
S
G
G
E
L
D
K
W
E
K
I
R
--
L
R
P
-------
G
---
G
K
K
--
Q
Y
---
K
L
K
H
I
V
W
A
S
--
R
E
L
E
R
F
A
V
N
P
G
L
L
E
T
S
E
G
-
C
-------
R
Q
I
L
G
Q
L
Q
----
P
S
L
Q
T
------
G
S
E
E
L
R
------
S
L
Y
N
T
I
-
A
V
L
Y
C
V
H
-------------------------------
Q
R
I
--------------
D
V
K
D
T
K
E
A
L
D
K
I
--------
E
---
E
E
Q
N
K
S
K
K
K
A
Q
Q
A
A
A
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
38.01
14%
49
- C1 -
3GRH
-
YBHC_ECOLI
A:
[-4-392]
------------------------------------------------------------------------------------------------------------------------
M
Q
R
P
S
D
Q
T
A
P
G
T
S
S
R
P
I
L
S
A
K
E
A
Q
---
N
F
D
A
Q
H
Y
F
A
------
S
L
------
T
P
G
A
A
-
A
W
N
P
S
P
I
T
L
P
AQP
D
F
V
V
G
P
A
G
T
Q
G
V
T
----
H
T
---------------------------------
T
I
Q
---
A
A
V
D
A
A
I
I
K
R
T
--
N
K
R
Q
Y
I
A
V
M
P
-----------------
G
E
Y
--
Q
G
T
------
V
Y
V
P
A
------
A
P
---
G
G
I
T
L
Y
G
T
G
E
K
P
I
-
D
V
K
I
G
L
--
S
--
L
D
G
-
G
M
S
P
A
D
--
W
R
H
D
-
V
N
P
--
R
-
G
K
------
Y
M
P
G
K
P
A
W
Y
M
Y
D
S
C
Q
S
K
R
S
D
S
I
G
V
L
C
S
A
V
F
W
S
Q
N
--
N
G
-
L
Q
L
Q
N
L
T
I
E
N
T
L
G
D
S
V
D
A
G
--
N
H
P
-------
A
V
A
L
R
T
D
G
D
Q
V
---
Q
I
N
N
V
N
I
L
G
R
Q
N
T
F
F
V
T
N
S
G
V
Q
N
R
L
---------------------------
E
T
N
------
R
Q
P
R
T
L
------
V
T
N
S
Y
I
-
E
G
-------
D
V
D
-
I
V
S
G
R
G
A
------
V
V
F
D
N
----
T
E
F
R
V
V
--------------
N
S
R
T
Q
Q
E
A
Y
V
F
A
--------
P
---
A
T
L
S
--
N
I
Y
Y
G
F
L
A
V
---------
N
S
R
F
N
A
F
-
G
D
------
G
V
A
-----
Q
L
G
R
S
L
D
--------
V
D
A
N
-------------------------
T
N
---
G
Q
V
V
I
R
--
D
-
S
A
I
N
E
G
F
NTAKP
W
A
D
A
V
I
S
N
R
P
-----
F
A
-------
G
N
T
G
S
V
D
D
N
D
E
I
Q
R
N
--------
L
N
D
T
N
Y
N
R
M
W
E
Y
N
N
R
GVGSK------------
9
HHSearch
37.76
10%
-36
- C5 -
2GLO
2
?
A:
[5-51]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
--
T
P
H
F
K
L
Q
V
L
E
S
Y
-
R
---
N
DNDCK----
G
N
Q
--
R
A
T
------
A
R
K
Y
---------------
N
I
H
-
R
R
Q
I
Q
K
-
W
L
Q
C
E
S
--
N
--
L
R
S
-
S
V
A
N
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------