@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0424: (2015-11-30 )
MIKLIAIDMDGTLLNDEKKIPKENIQAIKEATQAGIKIVLCTGRPMSGILPYFNELGLTKEEYIIMNNGCSTYSTKDWQLIDSATLTHDELIFLEEVVKEFPNVCLTLTAENTFYAVGEEVPEIVAYDADLVFTKAKSTSLDALRNQEEIVFQAMYMGLDADVTAFQEAVEEALISKFSGVRSQDYIYEIMPQGVTKARGLKSLIAKLGLDINQVMAIGDAPNDIELLDLVPNSVAMGNASDEIKSRCKYITVDNNKAGVAKAIYDYALR
Atome Classification :
(20 SA)
.........10......-.-.20........30........40........50....--...-.60-.-......----..70........80...--.....90.-.......100....------------....110.....--..120-----.------..--.----.-....-----130-------------.--.-..-.....-140..-.....-150...---...-.160.....--...170--------------------.---.......180----.---.....--...190.......200.......210.......220.......230.......240.......-250.......260--........270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
L
I
A
IDMDGTLLNDE-K-KI
P
K
E
N
I
Q
A
I
K
E
A
T
QAG
I
K
I
V
L
CTGRPM
S
G
I
L
P
Y
F
N
E--LGL-T
K
--
E
-
E
Y
I
I
MN----NGCSTYSTK
D
W
Q
L
IDSA--TLT
H
D
E
L
I
-
F
L
E
E
V
V
K
EF-PN
V
C
------------
L
T
L
TAEN
T
F
Y
A
V
--
G
EE-------V------
P
E
--
I
----V-AYDA-----
D
---------------
L
--
V
-
F
T-KAKST-
S
L
D
A
L-R
N
Q
E
E
-
I
V
F
Q
A
M
---
Y
MG-LD-A
D
V
T
A
F
--
Q
E
A
V
-
E
--------------------
E
---
A
L
I
S
K
F
SG------V---RSQ
D
Y
--
I
Y
E
I
MPQGV
T
K
A
R
G
L
K
S
L
I
A
K
LGL
D
I
N
Q
V
M
AIGDAPND
I
E
L
L
DLVPNSVAMGNA
S
D
E
I
K
SRC
K
-
Y
I
T
VDNNKA
G
V
A
---
K
A
I
Y
D
YALR
1
PsiBlast_PDB
91.08
31%
-104
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[5-271]
-
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
D
-
H
-
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
-
E
Q
--
P
G
D
Y
C
I
T
Y
----
N
G
A
L
V
Q
K
A
A
D
G
S
T
V
A
Q
T
--
A
L
S
Y
D
D
Y
R
-
F
L
E
K
L
S
R
E
V
-
G
S
H
F
------------
H
A
L
D
-
R
T
T
L
Y
T
A
--
N
R
D
-------
I
------
S
Y
--
Y
----
T
-
V
H
E
S
F
V
AT
I
P
---------------
L
--
V
-
F
C
-
E
A
E
K
---
M
D
P
N
-
T
Q
F
L
K
-
V
M
M
I
D
E
---
P
A
I
-
L
D
-
Q
A
I
A
R
I
--
P
Q
E
V
-
K
--------------------
E
-------
K
Y
T
V
------
L
---
K
S
A
P
Y
--
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
-
F
V
T
K
S
N
L
E
D
G
V
A
---
F
A
I
E
K
Y
V
L
N
21
PsiBlast_CBE
90.59
31%
-104
- C1 -
1RKQ
2
YIDA_ECOLI
B:
[5-271]
-
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
D
-
H
-
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
-
E
Q
--
P
G
D
Y
C
I
T
Y
----
N
G
A
L
V
Q
K
A
A
D
G
S
T
V
A
Q
T
--
A
L
S
Y
D
D
Y
R
-
F
L
E
K
L
S
R
E
V
-
G
S
H
F
------------
H
A
L
D
-
R
T
T
L
Y
T
A
--
N
R
D
-------
I
------
S
Y
--
Y
----
T
-
V
H
E
S
FVATI
P
---------------
L
--
V
-
F
C
-
E
A
E
K
---
M
D
P
N
-
T
Q
F
L
K
-
V
M
M
I
D
E
---
P
A
I
-
L
D
-
Q
A
I
A
R
I
--
P
Q
E
V
-
K
--------------------
E
-------
K
Y
T
V
------
L
---
K
S
A
P
Y
--
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
-
F
V
T
K
S
N
L
E
D
G
V
A
---
F
A
I
E
K
Y
V
L
N
36
HHSearch
88.97
29%
-107
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[4-271]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
D
-
H
-
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
E
Q
P
--
G
-
D
Y
C
I
T
Y
----
N
G
A
L
V
Q
K
A
A
D
G
S
T
V
A
Q
T
--
A
L
S
Y
D
D
Y
R
-
F
L
E
K
L
S
R
E
V
--
G
S
H
------------
F
H
A
L
D
R
T
T
L
Y
T
A
--
N
R
D
-------
I
------
S
Y
Y
T
V
----
H
-
E
S
F
V
-----
A
---------------
T
--
I
-
P
L
-
V
--
F
C
-
E
A
E
K
M
-
D
P
N
T
Q
--
F
L
K
V
M
---
M
I
D
-
E
P
-
A
I
L
D
Q
A
--
I
A
R
I
-
P
--------------------
Q
---
E
V
K
E
K
Y
T
V
------
L
---
K
S
A
P
Y
--
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
-
F
V
T
K
S
N
L
E
D
G
V
A
---
F
A
I
E
K
Y
V
L
N
2
PsiBlast_PDB
85.65
30%
-97
- C1 -
4DW8
4
?
A:
[6-265]
--
K
L
I
V
L
D
L
D
G
T
L
T
N
S
K
-
K
-
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
--
L
R
M
-
N
E
F-
G
-
G
F
I
L
S
Y
----
N
G
G
E
I
I
N
W
E
S
K
E
M
M
Y
E
N
--
V
L
P
N
E
V
V
P
-
V
L
Y
E
C
A
R
---
T
N
H
L
------------
S
I
L
T
Y
D
G
A
E
I
V
T
--
E
N
S
-------
L
------
D
P
--
Y
----
V
-
Q
K
E
A
-----
F
---------------
L
--
N
-
K
M
-
A
I
R
E
T
-
N
-
D
F
L
-
T
D
I
T
L
-
P
V
A
K
C
L
---
I
V
G
-
D
A
-
G
K
L
I
P
V
--
E
S
E
L
-
C
--------------------
I
---
R
L
Q
G
K
I
N
V
------
F
---
R
S
E
P
Y
--
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
-
Y
I
T
L
T
N
D
E
D
G
V
A
---
E
A
I
E
R
I
F
--
3
PsiBlast_PDB
85.36
29%
-98
- C1 -
3NIW
2
?
A:
[6-265]
--
K
L
I
V
L
D
L
D
G
T
L
T
N
S
K
-
K
-
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
--
L
R
M
-
N
E
F-
G
-
G
F
I
L
S
Y
----
N
G
G
E
I
I
N
W
E
S
K
E
M
M
Y
E
N
--
V
L
P
N
E
V
V
P
-
V
L
Y
E
C
A
R
---
T
N
H
L
------------
S
I
L
T
Y
D
G
A
E
I
V
T
--
E
N
S
-------
L
------
D
P
--
Y
----
V
-
Q
K
E
A
-----
F
---------------
L
--
N
-
K
M
-
A
I
R
E
T
-
N
-
D
F
L
-
T
D
I
T
L
-
P
V
A
K
C
L
---
I
V
G
-
D
A
-
G
K
L
I
P
V
--
E
S
E
L
-
C
--------------------
I
---
R
L
Q
G
K
I
N
V
------
F
---
R
S
E
P
Y
--
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
-
Y
I
T
L
T
N
D
E
D
G
V
A
---
E
A
I
E
R
I
F
--
18
PsiBlast_PDB
83.68
25%
-97
- C1 -
3DNP
1
YHAX_BACSU
A:
[7-273]
--
Q
L
L
A
L
N
I
D
G
A
L
L
R
S
N
-
G
-
K
I
H
Q
A
T
K
D
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
A
Q
K
I
A
K
S
--
L
K
L
-
D
A
--
K
---
L
I
T
H
----
S
G
A
Y
I
A
E
K
I
D
A
P
F
F
E
K
---
R
I
S
D
D
H
T
F
-
N
I
V
Q
V
L
E
S
Y
--
Q
C
N
------------
I
R
L
L
H
E
K
--
Y
S
I
--
G
N
K
KKVNS
N
L
L
------
G
K
--
A
----
L
-
I
H
P
S
-----
D
---------------
P
--
I
-
F
Y
-
P
V
Q
F
V
E
S
L
S
D
L
-
L
M
D
E
P
-
V
S
A
P
V
I
---
E
V
Y
-
T
E
-
H
D
I
-----
Q
H
D
I
-
T
--------------------
E
---
T
I
T
K
A
F
P
A
------
V
D
V
I
R
V
N
D
E
--
K
L
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
-
W
V
T
R
S
N
D
E
Q
G
V
A
---
Y
M
M
K
E
Y
F
R
M
10
PsiBlast_PDB
80.47
26%
-102
- C1 -
3R4C
4
?
A:
[11-267]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
E
T
H
-
K
V
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
----
H
E
--
I
D
A
-
V
P
--
Y
-
D
G
V
I
A
L
----
N
G
A
E
C
V
-
L
R
D
G
S
V
I
R
K
V
--
A
I
P
A
Q
D
F
R
-
K
S
M
E
L
A
R
E
F
-
D
F
A
V
A
L
ELNE
G
V
F
V
NR
L
T
P
T
V
E
Q
I
A
G
I
V
--
E
H
P
-------
V
------
P
P
--
V
----
V
---
D
I
-----
E
---------------
E
--
M
-
F
E
-
R
K
E
C
C
-
Q
L
--------------
C
F
---
Y
-----------
F
--
D
E
E
A
-
E
--------------------
Q
K
V
M
P
L
L
S
G
L
S
A
------
T
---
R
W
H
P
L
--
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
-
F
V
T
D
T
V
D
N
S
G
L
Y
---
K
A
L
K
H
F
G
V
I
41
HHSearch
79.78
25%
-100
- C1 -
3DNP
1
YHAX_BACSU
A:
[6-275]
-
K
Q
L
L
A
L
N
I
D
G
A
L
L
R
S
N
-
G
-
K
I
H
Q
A
T
K
D
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
A
Q
K
I
A
K
S
--
L
K
L
-----
D
-
A
K
L
I
T
H
----
S
G
A
Y
I
A
E
K
I
-
D
A
P
F
F
E
K
--
R
I
S
D
D
H
T
F
-
N
I
V
Q
V
L
E
S
Y
--
Q
C
N
------------
I
R
L
L
--
H
E
K
Y
S
I
--
G
N
K
-------
K
KVNS--
N
L
--
L
----
G
K
A
L
I
H
P
S
D
--
P
---------------
I
F-
Y
-
P
--
V
Q
F
V
E
-
S
L
S
D
L
-
L
M
D
E
P
V
S
A
P
V
I
E
---
V
Y
T
-
E
H
-
D
I
Q
H
D
I
--
T
E
T
I
-
T
--------------------
K
---
A
F
P
-
A
V
D
V
------
I
---
R
V
N
D
E
--
K
L
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
-
W
V
T
R
S
N
D
E
Q
G
V
A
---
Y
M
M
K
E
Y
F
R
M
16
PsiBlast_PDB
78.58
25%
-77
- C1 -
2RAV
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
-
K
A
I
I
N
N
L
S
E
--
L
Q
D
-
R
N
LI
D
-
G
Y
I
T
M
N
----
G
A
---
Y
C
F
V
G
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
-
G
V
P
C
------------
I
F
V
E
E
H
N
I
S
V
C
Q
--
P
N
E
-------
M
------
V
K
--
K
----
I
-
F
Y
D
F
---------------------
L
--
H
-
V
N
-
V
I
P
T
V
-
S
F
E
E
A
-
S
N
K
E
V
-
I
----------------
Q
M
T
P
F
IT
E
E
E
E
-
K
--------------------
E
---
V
L
P
S
I
P
T
C
------
E
---
I
G
R
W
Y
PA
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
37
HHSearch
78.20
25%
-98
- C1 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
S
K
-
H
-
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
--
L
G
I
-----
K
-
T
W
V
I
S
A
----
N
G
A
V
I
H
D
P
-
E
G
R
L
Y
H
H
E
--
T
I
D
K
K
R
A
Y
-
D
I
L
S
W
L
E
S
E
--
N
Y
Y
------------
Y
E
V
F
T
G
S
A
I
Y
T
P
--
Q
N
G
-------
R
------
E
L
--
L
D
V
E
L
D
-
R
F
R
S
-----
A
NPEAD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
-
S
G
-
F
A
Y
I
N
-
S
F
Q
E
L
F
E
A
D
E
P
I
D
F
Y
N
I
L
---
G
F
S
F
F
K
-
E
K
L
E
A
G
--
W
K
R
Y
----------------------
E
---
H
A
E
-
D
L
T
L
------
V
---
S
S
A
E
H
--
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
-
A
V
T
L
T
N
D
E
H
G
V
A
---
H
M
M
K
H
L
L
--
15
PsiBlast_PDB
78.16
25%
-75
- C1 -
2RAR
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
-
K
A
I
I
N
N
L
S
E
--
L
Q
D
-
R
N
LI
D
-
G
Y
I
T
M
N
----
G
A
---
Y
C
F
V
G
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
-
G
V
P
C
------------
I
F
V
E
E
H
N
I
S
V
C
Q
--
P
N
E
-------
M
------
V
K
--
K
----
I
-
F
Y
D
F
---------------------
L
--
H
-
V
N
-
V
I
P
T
V
-
S
F
E
E
A
-
S
N
K
E
V
-
I
----------------
Q
M
T
P
F
IT
E
E
E
E
-
K
--------------------
E
---
V
L
P
S
I
P
T
C
------
E
---
I
G
R
W
Y
PA
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
12
PsiBlast_PDB
78.11
25%
-73
- C1 -
2RB5
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
-
K
A
I
I
N
N
L
S
E
--
L
Q
D
-
R
N
LI
D
-
G
Y
I
T
M
N
----
G
A
---
Y
C
F
V
G
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
-
G
V
P
C
------------
I
F
V
E
E
H
N
I
S
V
C
Q
--
P
N
E
-------
M
------
V
K
--
K
----
I
-
F
Y
D
F
---------------------
L
--
H
-
V
N
-
V
I
P
T
V
-
S
F
E
E
A
-
S
N
K
E
V
-
I
----------------
Q
M
T
P
F
IT
E
E
E
E
-
K
--------------------
E
---
V
L
P
S
I
P
T
C
------
E
---
I
G
R
W
Y
PA
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
46
HHSearch
77.87
24%
-98
- C1 -
3R4C
4
?
A:
[11-266]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
E
T
H
-
K
V
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
D
-
A
--
V
P
------
Y
-
D
G
V
I
A
L
----
N
G
A
E
C
V
L
R
-
D
G
S
V
I
R
K
V
--
A
I
P
A
Q
D
F
R
-
K
S
M
E
L
A
R
E
F
--
D
F
A
------------
V
A
L
E
L
N
E
G
V
F
V
N
--
R
L
T
-------
P
------
T
---
V
----
E
-
Q
I
A
G
I
----
V
---------------
E
--
H
-
P
--
V
P
P
V
V
-
D
I
E
E
M
-
F
E
R
K
E
--
C
C
Q
L
C
---
F
Y
F
-
D
E
-
E
A
E
Q
K
V
--
M
P
L
L
----------------------------
S
-
G
L
S
A
------
T
---
R
W
H
P
L
--
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
-
F
V
T
D
T
V
D
N
S
G
L
Y
---
K
A
L
K
H
F
G
V
I
13
PsiBlast_PDB
77.70
25%
-75
- C1 -
2RBK
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
-
K
A
I
I
N
N
L
S
E
--
L
Q
D
-
R
N
LI
D
-
G
Y
I
T
M
N
----
G
A
---
Y
C
F
V
G
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
-
G
V
P
C
------------
I
F
V
E
E
H
N
I
S
V
C
Q
--
P
N
E
-------
M
------
V
K
--
K
----
I
-
F
Y
D
F
---------------------
L
--
H
-
V
N
-
V
I
P
T
V
-
S
F
E
E
A
-
S
N
K
E
V
-
I
----------------
Q
M
T
P
F
IT
E
E
E
E
-
K
--------------------
E
---
V
L
P
S
I
P
T
C
------
E
---
I
G
R
W
Y
PA
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
9
PsiBlast_PDB
76.92
30%
-80
- C1 -
2B30
2
?
A:
[27-298]
-
I
K
L
L
L
I
D
F
D
G
T
L
F
V
D
K
-
D
I
K
V
P
S
E
N
I
D
A
I
K
E
A
I
E
K
G
Y
M
V
S
I
C
T
G
R
S
K
V
G
I
L
S
A
F
G
E
--
E
N
L
-
K
K
--
M
-
N
F
Y
G
M
P
G
V
Y
I
N
G
T
I
V
Y
D
Q
I
G
Y
T
L
L
D
E
T
I
E
T
D
V
Y
A
E
L
I
S
Y
L
V
E
--
K
N
L
-
V
N
Q
T
------------
I
F
H
R
G
E
S
N
Y
---------------
V
------
T
E
--
D
----
N
-
K
Y
-
A
-----
D
---------------
F
--
L
-
Q
K
-
M
Y
S
E
N
-
R
S
I
I
I
-
R
H
N
E
M
-
L
K
Y
R
T
M
N
K
L
M
I
V
-
L
D
P
S
E
S
K
T
V
--
I
G
N
L
-
K
--------------------
Q
---
K
F
K
N
K
L
T
I
------
F
---
T
T
Y
N
G
--
H
A
E
V
T
K
L
G
H
D
K
Y
T
G
I
N
Y
L
L
K
H
Y
N
I
S
N
D
Q
V
L
V
V
G
D
A
E
N
D
I
A
M
L
S
N
F
K
Y
S
F
A
V
A
N
A
T
D
S
A
K
S
H
A
K
C
V
L
P
V
S
H
R
E
G
A
V
A
Y
L
L
K
K
V
F
D
L
K
--
11
PsiBlast_PDB
76.79
25%
-75
- C1 -
1YMQ
3
?
A:
[2-260]
-
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
-
K
A
I
I
N
N
L
S
E
--
L
Q
D
-
R
N
LI
D
-
G
Y
I
T
M
N
----
G
A
---
Y
C
F
V
G
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
-
G
V
P
C
------------
I
F
V
E
E
H
N
I
S
V
C
Q
--
P
N
E
-------
M
------
V
K
--
K
----
I
-
F
Y
D
F
---------------------
L
--
H
-
V
N
-
V
I
P
T
V
-
S
F
E
E
A
-
S
N
K
E
V
-
I
----------------
Q
M
T
P
F
IT
E
E
E
E
-
K
--------------------
E
---
V
L
P
S
I
P
T
C
------
E
---
I
G
R
W
Y
PA
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
6
PsiBlast_PDB
76.54
26%
-80
- C1 -
1NRW
2
YWPJ_BACSU
A:
[5-282]
--
K
L
I
A
I
D
L
D
G
T
L
L
N
S
K
-
H
-
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
--
L
G
I
-----
K
-
T
W
V
I
S
A
----
N
G
A
V
I
H
D
P
E
-------
G
--
R
L
Y
H
H
E
T
I
-----
D
K
K
R
A
-
Y
D
I
L
------------
S
W
L
E
S
E
N
Y
Y
Y
E
V
F
T
G
S
A
-------
I
YTPQN
G
R
E
--
L
----
L
-
D
V
E
L
-----
D
---------------
R
--
F
-
R
S
-
A
N
P
E
A
-
D
L
S
V
L
-
K
Q
A
A
E
-
V
Q
Y
S
Q
S
---
G
F
-----
A
Y
I
N
S
F
--
Q
E
L
F
-
E
AD
E
P
I
D
F
Y
N
I
L
G
F
S
FF
K
E
K
L
E
---
A
G
W
K
R
Y
E
H
AED
L
T
L
V
---
S
S
A
E
H
--
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
-
A
V
T
L
T
N
D
E
H
G
V
A
---
H
M
M
K
H
L
L
--
39
HHSearch
75.46
21%
-103
- C1 -
1NF2
3
?
A:
[1-263]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
D
N
-
L
-
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
Y
-
F
K
R
-----
T
-
F
P
T
I
A
Y
----
N
G
A
I
V
Y
L
P
E
-
E
G
V
I
L
N
E
--
K
I
P
P
E
V
A
K
-
D
I
I
E
Y
I
K
P
L
--
N
V
H
------------
W
Q
A
Y
I
D
D
V
L
Y
S
E
--
K
D
N
-------
E
------
E
---
I
----
K
-
S
Y
A
R
-----
H
S
--------------
N
--
V
-
D
--
Y
R
V
E
P
-
N
L
S
E
L
-
V
S
K
M
G
--
T
T
K
L
L
---
L
I
D
-
T
P
-
E
R
L
D
E
L
--
K
E
I
L
-
S
--------------------
E
---
R
F
K
D
V
V
K
V
------
F
---
K
S
F
P
T
--
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
-
I
V
T
L
T
N
N
D
S
G
V
S
---
Y
V
L
E
R
I
S
T
D
45
HHSearch
75.27
23%
-88
- C1 -
2RBK
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
-
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
R
N
L
-----
I
-
D
G
Y
I
T
M
----
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
K
S
--
A
I
P
Q
E
E
V
K
-
A
M
A
A
F
C
E
K
K
--
G
V
P
------------
C
I
F
V
E
E
H
N
I
S
V
C
--
Q
P
N
-------
E
------
M
---
V
----
K
-
K
I
F
Y
-----
D
---------------
F
--
L
-
H
V
N
V
I
P
T
V
-
S
F
E
E
A
--
S
N
K
E
--
V
I
Q
M
T
---
P
F
I
-
T
E
-
E
E
E
K
E
V
-----
L
----------------------
P
---
S
I
P
-
T
C
E
I
------
G
---
R
W
Y
P
A
--
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
-
Y
V
T
A
P
I
D
E
D
G
I
S
---
K
A
M
K
H
F
G
I
I
43
HHSearch
75.03
23%
-108
- C1 -
3DAO
1
?
A:
[20-283]
M
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
G
-
S
L
L
I
D
P
E
Y
M
S
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
Q
F
S
S
E
F
K
L
F
A
P
--
I
K
H
-----
K
-
L
L
Y
I
T
D
----
G
G
T
V
V
R
T
P
--
K
E
I
L
K
T
Y
--
P
M
D
E
D
I
W
K
-
G
M
C
R
M
V
R
D
E
L
P
A
C
D
------------
Y
F
A
A
T
P
D
F
C
F
A
E
--
D
G
G
-------
S
------
P
---
I
----
F
-
H
L
L
R
-----
D
---------------
S
--
Y
G
F
E
-
M
R
E
V
D
-
D
I
T
R
L
--
D
R
N
D
--
I
I
K
F
T
---
V
F
H
-
P
D
-
K
-
C
E
E
L
--
C
T
P
V
F
I
--------------------
P
---
A
W
N
K
K
A
H
L
------
A
---
A
A
G
K
E
--
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
-
H
T
C
A
P
Y
W
E
N
G
V
L
---
S
V
L
K
S
F
L
--