@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0435: (2015-11-30 )
MKLTTLGCWGGYPYKDGGTTSFLLTGENNFHLLIDAGSRSINELEKEISPLDLDAVIISHYHPDHVADLGVLYHYRLLYPKDKWEPKVLPVYGHNEDDYEFSKLTLPNVAQGIAYHTNGVEQVGPFNITFIKTVHPVVCYAMRITERETGQVLVFTGDSGYFADLVPFTKGADLFLADVYLYEGNENHIAHLTSKEAGEIAYNAKVKKLVLTHVPQFPGEGINPENHLEELRLQSEKYAGGISVDLAQPHKSWDLGKL
Atome Classification :
(20 SA)
-----..-.-.....-----------------.10....----------------..------------------..20....----------------.-----.---..30---.......--------------------------------------------.40-..-----.----------------.--------.---.------.-.---.50..-.......60........-70........80..------......90..-......100-.....-----------.---------------.------------------..110-------.......-120------..-.----...----..130-..-.---------.----------..--------------.140.......-------------------------------------------------.------------------------------------------------150-.........160--------------...-.-..-----..----.--170..--....-...180--.....---...190--..-.......200.....----------..210.......220.......230....-...240--.........250......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
K
-
L
-
T
T
L
GC-----------------WGGYPYK----------------DG------------------G
T
T
S
F
L
L
T----------------G-----E---N
N
F
H
---
L
L
I
DAGS--------------------------------------------R
S
--
I
N
-----
E
----------------
L
--------
E
---
K
------E-I---SP-L
D
-
L
D
A
V
I
I
SHYHP
D
H
V
A
D
L
-
G
V
L
Y
H
Y
R
LLYPKDK------WEP
K
V
L
P
V
YG-HNEDDYE---FSKLT-----------L---------------
P
------------------
N
V
A
Q
G
-------
I
A
YHTNG-VE-------QV-G----PF
N
----
I
T
F
I
K-T
V
-
H
---------
P
----------
V
V
--------------
C
Y
A
-MRITERE-------------------------------------------------T------------------------------------------------
G
---
Q
V
L
V
F
TGDSG----------------
Y
F
A
-D-LV-----PF----T--K--GA--
D
L
F
L
-
A
D
V
Y
L
---YEGNE---N
H
I
A
----HL-TSKEAG
E
I
A
YNA
K
V
K
----------
K
L
V
L
T
HVPQFPGEGI
N
P
E
N
H
L
E
E
L
R
L
Q
S
E-KYAG----
G
I
S
V
DLAQPHKSWDLGKL
22
HHSearch
99.48
42%
-112
* C2 *
1ZKP
3
?
A:
[25-268]
-----
M
K
-
M
-
T
V
V
G
F
-----------------
W
G
G
F
P
E
A
----------------
G
E
------------------
A
T
S
G
Y
L
F
E
----------------
H
-----
D
----
G
F
R
---
L
L
V
D
C
G
S
--------------------------------------------
G
V
--
L
A
-----
Q
----------------
L
--------
Q
---
K
------
Y
-
I
---
T
P
-
S
D
-
I
D
A
V
V
L
S
H
Y
H
H
D
H
V
A
D
I
-
G
V
L
Q
Y
A
R
L
I
T
S
A
T
K
------
G
Q
L
P
E
L
P
I
Y
G
-
H
T
F
D
E
N
G
---
F
H
S
L
T
-----------
H
---------------
E
------------------
P
H
T
K
G
-------
I
P
Y
N
P
E
E
-
T
L
-------
Q
I
-
G
----
P
F
S
----
I
S
F
L
K
-
T
V
-
H
---------
P
----------
V
T
--------------
C
F
A
-
M
R
I
T
--
A
-------------------------------------------------
G
------------------------------------------------
N
---
D
I
V
V
Y
S
A
D
S
S
----------------
Y
I
P
-
E
-
F
I
-----
P
F
----
T
--
K
--
D
A
--
D
L
F
I
-
C
E
C
N
M
---
Y
A
H
Q
E
A--
A
K
A
G
----
H
M
-
N
S
T
E
V
A
S
I
A
K
D
A
N
V
K
----------
E
L
L
L
T
H
L
P
H
T
G
----
N
----
P
A
D
L
V
T
E
A
K
-
Q
I
F
S
-----
G
H
I
T
L
A
H
S
G
Y
V
W
N
S
---
44
Fugue
92.20
39%
-95
- C2 -
1ZKP
3
?
A:
[18-268]
LYFQS
N
A
M
K
M
T
V
V
G
F
-----------------
W
G
G
F
P
E
A
----------------
G
E
------------------
A
T
S
G
Y
L
F
E
----------------
H
---------
D
G
F
R
---
L
L
V
D
C
G
S
--------------------------------------------
G
V
--
L
A
-----
Q
----------------
L
--------
Q
---
K
------
Y
-
I
---
T
P
-
S
D
-
I
D
A
V
V
L
S
H
Y
H
H
D
H
V
A
D
I
-
G
V
L
Q
Y
A
R
L
I
T
S
A
T
K
------
G
Q
L
P
E
L
P
I
Y
G
-
H
T
F
D
E
N
G
---
F
H
S
L
T
-----------
H
---------------
E
------------------
P
H
T
K
G
-------
I
P
Y
N
P
E
E
-
T
L
-------
Q
I
-
G
----
P
F
S
----
I
S
F
L
K
-
T
V
-
H
---------
P
----------
V
T
--------------
C
F
A
M
R
I
T
A
G
----------------------------------------------------------------------------------------------------
N
---
D
I
V
V
Y
S
A
D
S
S
----------------
Y
I
P
-
E
-
F
I
-----
P
F
----
T
--
K
--
D
A
--
D
L
F
I
-
C
E
C
-
N
M--
Y
A
H
Q
E
---
A
A
K
A
----
G
H
M
N
S
T
E
V
A
S
I
A
K
D
A
N
V
K
----------
E
L
L
L
T
H
L
P
--------
H
T
G
N
P
A
D
L
V
T
E
A
K
-
Q
I
F
S
----
G
-
H
I
T
L
A
H
S
G
Y
V
W
N
S
---
1
PsiBlast_PDB
92.09
44%
-114
- C2 -
1ZKP
3
?
A:
[26-238]
------
K
-
M
-
T
V
V
G
F
-----------------
W
G
G
F
P
-
E
----------------
A
G
------------------
E
A
T
S
G
Y
L
F
----------------
E
-----
H
---
D
G
F
R
---
L
L
V
D
C
G
S
--------------------------------------------
G
V
--
L
A
-----
Q
----------------
L
--------
Q
---
K
------
Y
-
I
---
T
P
-
S
D
-
I
D
A
V
V
L
S
H
Y
H
H
D
H
V
A
D
I
-
G
V
L
Q
Y
A
R
L
I
T
S
A
T
K
------
G
Q
L
P
E
L
P
I
Y
G
-
H
T
F
D
E
N
G
---
F
H
S
L
T
-----------
H
---------------
E
------------------
P
H
T
K
G
-------
I
P
Y
N
P
E
E
-
T
L
-------
Q
I
-
G
----
P
F
S
----
I
S
F
L
K
-
T
V
-
H
---------
P
----------
V
T
--------------
C
F
A
-
M
R
I
T
A
G
N
------------------------------------------------------------------------------------------------------
D
I
V
V
Y
S
A
D
S
S
----------------
Y
I
P
-
E
-
F
I
-----
P
F
----
T
--
K
--
D
A
--
D
L
F
I
-
C
E
C
N
M
---
Y
A
H
Q
E
---
A
A
K
A
G---
H
M
-
N
S
T
E
V
A
S
I
A
K
D
A
N
V
K
----------
E
L
L
L
T
H
L
P
H
T
G
N
P
A
D
L
V
T
E
A
K
Q
I
F
S
G
H
I
T
-
L
A
H
S
----
G
Y
V
W
N
S
------------
23
HHSearch
80.51
25%
-90
- C2 -
2CBN
2
RBN_ECOLI
A:
[2-306]
-----
M
N
-
L
-
I
F
L
G
T
-----------------
S
A
G
V
P
T
R
----------------
T
R
------------------
N
V
T
A
I
L
L
N
----------------
L
-----
Q
HPT
Q
S
G
L
---
W
L
F
D
C
G
E
--------------------------------------------
G
T
--
Q
H
-----
Q
----------------
L
--------
L
---
H
------
T
A
F
---
N
P
-
G
K
-
L
D
K
I
F
I
S
H
L
H
G
D
H
L
F
G
L
-
P
G
L
L
C
S
R
S
M
S
G
I
----------
I
Q
P
L
T
I
Y
G
-
P
Q
G
I
R
E
F
---
V
E
T
A
L
R
I
S
GS------
W
T--------------
D
------------------
Y
P
L
E
I
-------
V
E
I
G
A
G
E
-
I
L
-------
D
D
-
G
----
L
R
K
----
V
T
A
Y
P
-
L
E
-
H
---------
P
----------
L
E
--------------
C
Y
G
-
Y
R
I
E
-
E
H
DAPGALN
A
Q
A
L
K
A
A
GVPPGPL
F
Q
E
L
K
A
GKTITLEDG
R
Q
I
N
GADYLAAP
V
P
------------------------------------------------
G
---
K
A
L
A
I
F
G
D
T
G
----------------
P
C
D
-
A
-
A
L
-----
D
L
----
A
--
K
--
G
V
--
D
V
M
V
-
H
E
A
T
L
---
D
I
T
M
E
A
K
A
N
S
R
G
----
H
S
-
S
T
R
Q
A
A
T
L
A
R
E
A
G
V
G
----------
K
L
I
I
T
H
V
S
S
R
Y
D
D
K
-----
G
C
Q
H
L
L
R
E
C
R
-
S
I
F
P
------
A
T
E
L
A
N
D
F
T
V
F
N
V
---
3
PsiBlast_PDB
77.45
20%
-103
- C2 -
4GCW
3
RNZ_BACSU
A:
[1-270]
-----
M
E
-
L
-
L
F
L
G
T
-----------------
G
A
G
I
P
A
K
----------------
A
R
------------------
N
V
T
S
V
A
L
K
LL--------------
E
-----
E
---
R
R
S
V
---
W
L
F
D
C
G
E
--------------------------------------------
A
T
--
Q
H
-----
Q
M
---------------
L
--------
H
---
T
------
T
-
I
---
K
P
-
R
K
-
I
E
K
I
F
I
T
H
M
H
G
D
H
V
Y
G
L
P
G
L
L
G
S
R
S
F
Q
G
G
E
D
E
L
T
V
---
Y
G
P
K
G
I
K
A
F
I
-
E
T
S
L
A
V
T
---
K
T
H
L
T
-----------
Y
---------------
P
L
A
I
Q
--------------
E
I
E
E
G
-------
I
V
F
E
D
D
-------------------
Q
F
I
----
V
T
A
V
S
-
V
I
-
H
---------
G
----------
V
E
--------------
A
F
G
-
Y
R
V
Q
E
K
D
-------------------------------------------------
V
PGSLK
A
D
V
L
K
E
M
NIPPG
P
V
Y
Q
K
I
K
K
GETVTLED
G
R
I
I
N
GNDFLE
P
P
K
K
G
---
R
S
V
V
F
S
G
D
T
R
----------------
V
S
D
-
K
-
L
K
-----
E
L
----
A
--
R
--
D
C
--
D
V
M
V
-
H
E
A
-
T
---
F
A
K
E
D
---
R
K
L
A
Y
D
Y
Y
H
S
-
T
T
E
Q
A
A
V
T
A
K
E
A
R
A
K
----------
Q
L
I
L
T
H
I
S
A
R
Y
Q
G
D
A
S
L
E
L
Q
K
E
A
V
D
V
F
P
N
-
S
V
A
A
----
Y
D
F
L
E
V
N
V
P
R
G
-------
4
PsiBlast_PDB
76.64
20%
-102
- C2 -
2FK6
3
RNZ_BACSU
A:
[1-270]
-----
M
E
-
L
-
L
F
L
G
T
-----------------
G
A
G
I
P
A
K
----------------
A
R
------------------
N
V
T
S
V
A
L
K
LL--------------
E
-----
E
---
R
R
S
V
---
W
L
F
D
C
G
E
--------------------------------------------
A
T
--
Q
H
-----
Q
M
---------------
L
--------
H
---
T
------
T
-
I
---
K
P
-
R
K
-
I
E
K
I
F
I
T
H
M
A
G
D
H
V
Y
G
L
P
G
L
L
G
S
R
S
F
Q
G
G
E
D
E
L
T
V
---
Y
G
P
K
G
I
K
A
F
I
-
E
T
S
L
A
V
T
---
K
T
H
L
T
-----------
Y
---------------
P
L
A
I
Q
--------------
E
I
E
E
G
-------
I
V
F
E
D
D
-------------------
Q
F
I
----
V
T
A
V
S
-
V
I
-
H
---------
G
----------
V
E
--------------
A
F
G
-
Y
R
V
Q
E
K
D
-------------------------------------------------
V
PGSLK
A
D
V
L
K
E
M
NIPPG
P
V
Y
Q
K
I
K
K
G
E
T
V
T
L
EDG
R
I
I
N
GNDFLEPPK
K
G
---
R
S
V
V
F
S
G
D
T
R
----------------
V
S
D
-
K
-
L
K
-----
E
L
----
A
--
R
--
D
C
--
D
V
M
V
-
H
E
A
-
T
---
F
A
K
E
D
---
R
K
L
A
Y
D
Y
Y
H
S
-
T
T
E
Q
A
A
V
T
A
K
E
A
R
A
K
----------
Q
L
I
L
T
H
I
S
A
R
Y
Q
G
D
A
S
L
E
L
Q
K
E
A
V
D
V
F
P
N
-
S
V
A
A
----
Y
D
F
L
E
V
N
V
P
R
G
-------
24
HHSearch
74.91
22%
-92
- C2 -
1Y44
5
RNZ_BACSU
A:
[1-306]
-----
M
E
-
L
-
L
F
L
G
T
-----------------
G
A
G
I
P
A
K
----------------
A
R
------------------
N
V
T
S
V
A
L
K
----------------
L
LEE--
R
----
R
S
V
---
W
L
F
D
C
G
E
--------------------------------------------
A
T
--
Q
H
-----
Q
----------------
M
--------
L
---
H
------
T
T
I
---
K
P
-
R
K
-
I
E
K
I
F
I
T
H
M
H
G
D
H
V
Y
G
L
-
P
G
L
L
G
S
R
S
F
Q
G
G
----------
E
D
E
L
T
V
Y
G
-
P
K
G
I
K
A
F
---
I
E
T
S
L
-----------
A
V
T
KTHL---------
T
------------------
Y
P
L
A
I
-------
Q
E
I
E
E
G
I
-
V
F
-------
E
D
-
D
----
Q
F
I
----
V
T
A
V
S
-
V
I
-
H
---------
G
----------
V
E
--------------
A
F
G
-
Y
R
V
Q
-
E
K
D
V
P
G
SLLE
P
P
K
--------------------------------------
K
------------------------------------------------
G
---
R
S
V
V
F
S
G
D
T
R
----------------
V
S
D
-
K
-
L
K
-----
E
L
----
A
--
R
--
D
C
--
D
V
M
V
-
H
E
A
T
F
---
A
K
E
D
R
K
L
A
Y
D
Y
Y
----
H
S
-
T
T
E
Q
A
A
V
T
A
K
E
A
R
A
K
----------
Q
L
I
L
T
H
I
S
A
R
Y
Q
G
D
-----
A
S
L
E
L
Q
K
E
A
V
-
D
V
F
P
------
N
S
V
A
A
Y
D
F
L
E
V
N
V
P
R
G
25
HHSearch
74.20
16%
-107
- C2 -
3G1P
5
PHNP_ECOLI
A:
[3-250]
-----
L
T
-
L
-
T
L
T
G
T
-----------------
G
G
A
Q
G
V
P
----------------
A
W
GCEC
A
A
C
A
R
A
R
R
S
PQYRR
Q
P
C
S
G
V
V
K
----------------
F
-----
N
----
D
A
I
---
T
L
I
D
A
G
L
--------------------------------------------
H
D
--
L
A
-----
D
------------------------------------
R
-
W
---
S
P
-
G
S
-
F
Q
Q
F
L
L
T
H
Y
H
M
D
H
V
Q
G
L
-
F
P
L
R
W
G
V
---------------
G
D
P
I
P
V
Y
G
-
P
P
D
E
Q
G
C
---
D
D
L
F
K
-----------
H
---------------
P
------------------
G
L
L
D
F
S------
H
T
V
E
P
F
V
-
V
F
-------
D
L
-
Q
----
G
L
Q
----
V
T
P
L
P
-
L
N
-
H
---------
S
----------
K
L
--------------
T
F
G
-
Y
L
L
E
--
T
-------------------------------------------------
A
------------------------------------------------
H
---
S
R
V
A
W
L
S
D
T
A
----------------
G
L
P
E
K
-
T
L
-----
K
F
----
L
--
R
N
N
Q
P
--
Q
V
M
V
-
M
D
C
S
H
---
P
P
R
A
D
---
A
P
R
N
----
H
C
-
D
L
N
T
V
L
A
L
N
Q
V
I
R
S
P
----------
R
V
I
L
T
H
I
S
H
Q
F
----
D
----
A
-
W
L
M
E
N
----
A
L
P
-----
S
G
F
E
V
G
F
D
G
M
E
I
G
----
2
PsiBlast_PDB
73.11
23%
-96
- C2 -
2CBN
2
RBN_ECOLI
A:
[2-272]
-----
M
N
-
L
-
I
F
L
G
T
-----------------
S
A
G
V
P
T
R
----------------
T
R
------------------
N
V
T
A
I
L
L
N
----------------
L
-----
Q
---
H
P
T
Q
S
G
L
W
L
F
D
C
G
E
--------------------------------------------
G
T
--
Q
H
-----
Q
----------------
L
L
-------
H
---
T
------
A
-
F
---
N
P
-
G
K
-
L
D
K
I
F
I
S
H
L
H
G
D
H
L
F
G
L
-
P
G
L
L
C
S
R
S
M
--
S
G
I
------
I
Q
P
--
L
T
I
Y
G
--
P
Q
G
I
R
E
---
F
V
E
T
A
-----------
L
---------------
R
------------------
I
S
G
S
W
-------
T
D
Y
P
L
E
I
-
V
E
IGAGEIL
D
D
-
G
----
L
R
K
----
V
T
A
Y
P
-
L
E
-
H
---------
P
----------
L
E
--------------
C
Y
G
-
Y
R
I
E
E
H
D
-------------------------------------------------
A
PGALN
A
Q
A
L
K
A
A
GVPPGPL
F
Q
E
L
K
A
GKTITLEDG
R
Q
I
N
GADYLAAP
V
P
G
---
K
A
L
A
I
F
G
D
T
G
----------------
P
C
D
-
A
-
A
L
-----
D
L
----
A
--
K
--
G
V
--
D
V
M
V
-
H
E
A
T
L
DIT
M
E
A
K
A
---
N
S
R
G
----
H
S
-
S
T
R
Q
A
A
T
L
A
R
E
A
G
V
G
----------
K
L
I
I
T
H
V
S
S
R
Y
D
D
K
G
C
Q
H
L
L
R
E
C
R
S
I
F
P
A
-
T
E
L
A
----
N
D
F
T
V
F
N
V
----------
26
HHSearch
70.37
19%
-105
- C2 -
3MD7
7
?
A:
[29-292]
-----
L
R
-
F
-
T
L
L
G
C
-----------------
G
S
S
P
G
V
P
RINGDWGKCDPKNPKN
R
R
------------------
R
R
A
S
L
L
V
E
----------------
R
Y
D
AEG
N
----
N
T
V
---
V
V
I
D
T
G
P
--------------------------------------------
D
F
--
R
M
-----
Q
----------------
M
--------
I
---
D
------
S
-----
G
V
-
H
M
-
L
D
A
A
V
Y
T
H
P
H
A
D
H
I
H
G
I
-
D
D
L
R
T
Y
V
V
D
------------
N
G
R
L
M
D
V
Y
A
-
N
R
L
T
R
N
R
---
L
Y
D
T
F
GYCFETPVGSS
Y
---------------
P
------------------
P
I
L
S
M
-------
H
D
I
A
P
E
T
-
P
F
-------
S
I
-
E
G
AG
G
A
I
R
----
F
E
P
F
S
-
Q
V
-
H
---------
G
D---------
I
E
--------------
S
L
G
-
F
R
I
G
----------------------------------------------------------------------------------------------------------
S
V
V
Y
C
T
D
V
S
----------------
A
F
P
-
E
Q
S
L
-----
Q
Y
----
I
--
K
--
D
A
--
D
V
L
I
-
I
G
A
L
Q
---
Y
R
P
------
H
P
S
----
H
F
-
S
L
G
E
A
L
E
W
I
E
K
L
S
P
K
----------
R
A
I
L
T
H
M
H
V
P
L
----
D
----
Y
E
T
V
----
M
-
R
E
T
P
-----
H
H
V
E
P
G
Y
D
G
L
R
F
E
V
A
V
-
48
Fugue
70.29
17%
-90
- C2 -
3G1P
5
PHNP_ECOLI
A:
[2-250]
----S
L
T
-
L
-
T
L
T
G
T
GGAQGVPAWGCEC
A
A
C
A
R
A
R
R
S
P
Q
----------------
Y
R
------------------
R
Q
P
C
S
G
V
V
----------------
K
-----
F
---
N
D
A
I
---
T
L
I
D
A
G
-------------------------------------------------
L
H
-----
D
----------------
L
--------
A
---
D
------
R
-
W
---
S
P
-
G
S
-
F
Q
Q
F
L
L
T
H
Y
H
M
D
H
V
Q
G
L
-
F
---------
P
L
R
W
------
G
V
G
D
P
I
P
V
Y
G
P
P
D
E
Q
G
C
D
---
D
L
F
K
H
-----------
P
---------------
G
------------------
L
L
D
F
S
-------
H
T
V
E
P
F
V
-
V
F
-------
D
L
-
Q
----
G
L
Q
----
V
T
P
L
P
-
L
N
-
H
---------
S
----------
K
L
--------------
T
F
G
-
Y
L
L
E
-
T
A
-------------------------------------------------
H
------------------------------------------------
S
---
R
V
A
W
L
S
D
T
A
G
----------------
L
P
E
-
K
-
T
L
-----
K
F
----
L
--
R
--
N
N
QP
Q
V
M
V
-
M
D
C
S
H
---
P
P
R
A
D
---
A
P
R
N
----
H
C
-
D
L
N
T
V
L
A
L
N
Q
V
I
R
S
P
----------
R
V
I
L
T
H
I
S
----
H
Q
F
D
A
W
L
M
E
N
A
L
P
S
G
F
E
-
V
G
F
D
----
G
M
E
I
G
-------------
50
Fugue
69.31
23%
-97
- C2 -
4OJV
4
PDE1_YEAST
A:
[1-369]
--MVV
F
E
-
I
-
T
I
L
G
A
-----------------
N
G
G
P
--
T
----------------
E
Y
------------------
G
T
Q
C
F
I
L
K
P
A
RTEDP
E
L
I
A
VDGGA
G
-----
M
---
Y
Q
L
R
---
E
M
L
V
Q
G
D
D
E
L
V
P
S
FYEHDREP
I
E
F
F
I
DSKLNIQKGLS
K
S
L
L
Q
S
L
K
RQ
G
E
H
F
E
S
--
A
N
-----
T
----------------
M
--------
K
---
K
------
T
-
Y
---
E
V
-
F
Q
G
I
T
D
Y
Y
I
T
H
P
H
L
D
H
I
--
S
-
G
L
V
V
N
S
P
S
I
Y
E
Q
E
N
------
S
K
K
K
T
I
W
G
L
P
-
H
T
I
D
V
L
Q
K
HV
F
N
D
L
I
-----------
W
---------------
P
------------------
D
L
T
A
E
RSRK
L
K
L
K
C
L
N
P
K
E
-
V
Q
-------
K
C
-
T
----
I
F
P
----
W
D
V
I
P
F
K
V
-
H
HGIGVKTG
A
P
----------
V
Y
--------------
S
T
F
-
Y
I
F
R
D
R
K
-------------------------------------------------
S
------------------------------------------------
K
---
D
C
I
I
V
C
G
D
V
E
Q
D
R
RESEES
L
L
E
E
F
W
S
Y
V
A
-
E
-
N
I
-----
P
L
----
V
--
H
--
L
K
--
G
I
L
V
E
C
S
C
P
L
---
S
S
K
P
E
---
Q
L
Y
G
----
H
L
-
S
P
I
Y
L
I
N
E
L
S
N
L
N
T
L
Y
NSSKGLSG
L
N
V
I
V
T
H
V
K
S
T
P
A
K
R
D
P
R
L
T
I
L
E
E
L
R
F
L
A
E
E
R
N
L
G
----
D
L
R
I
S
I
A
L
E
G
H
T
L
F
L
---
46
Fugue
62.90
17%
-82
- C2 -
1WW1
1
?
A:
[1-280]
---------------------------------
M
N
I
I
G
F
----------------
S
K
------------------
A
L
F
S
T
W
I
Y
----------------
Y
-----
S
---
P
E
-
R
---
I
L
F
D
A
G
E
--------------------------------------------
G
V
--
S
T
-----
T
----------------
L
--------
G
---
S
------
K
-
V
---
Y
A
-
F
K
---
Y
V
F
L
T
H
G
H
V
D
H
I
A
G
L
-
W
G
V
V
N
I
R
N
N
G
M
G
D
R
E
K
P
L
D
V
F
Y
P
E
G
N
R
A
V
E
-
E
Y
T
E
F
I
K
---
R
A
N
P
D
-----------
L
---------------
R
------------------
F
S
F
N
V
-------
H
P
L
K
E
G
E
-
R
V
-------
F
L
-
R
----
N
A
G
G
F
K
R
Y
V
Q
P
F
-
R
T
-
K
---------
S
----------
E
V
--------------
S
F
G
-
Y
H
I
F
E
V
R
R
KFV
T
E
E
Y
-----------------------------------------
H
------------------------------------------------
K
---
K
V
L
T
I
S
G
D
S
L
----------------
A
L
D
----
P
-----
E
E
----
I
--
R
--
G
T
--
E
L
L
I
-
H
E
C
T
F
---
L
D
A
R
D
---
N
H
-------
A
-
A
I
D
E
V
M
E
S
V
K
A
A
G
V
K
----------
K
V
I
L
Y
H
I
S
T
------
R
Y
I
R
Q
L
K
S
V
I
K
K
Y
R
-
E
E
M
P
----
D
V
E
I
L
Y
M
D
P
R
K
V
F
E
M
---
28
HHSearch
62.04
15%
-91
- C2 -
3RPC
2
?
A:
[5-264]
-----
T
Q
-
Y
-
T
H
I
R
--------------------------------------------------------------
N
A
T
G
K
L
T
----------------
I
-----
K
----
N
T
T
---
F
L
I
D
P
F
L
--------------------------------------------
A
P
--
K
D
-----
T
YPGFEGTFNYQQRMPM
V
--------
D
---
L
------
P
-
L
S
M
D
D
L
L
S
N
-
V
T
A
V
V
V
T
H
T
H
L
D
H
W
D
D
T
-
A
I
N
S
I
-----------------
P
K
S
L
P
I
F
V
-
Q
N
T
A
D
K
E
L
--
I
T
S
Q
G
-----------------------------------------------
F
I
D
---------
V
R
I
I
F
E
-
S
L
-------
E
F
-
N
----
G
I
T
----
L
R
K
T
G
-
G
S
-
H
---------
G
----------
T
V
E
M
Y
A
N
P
V
L
A
P
L
A
G
D
A
M
G
-
V
I
F
E
-
A
A
-------------------------------------------------
D
------------------------------------------------
E
---
P
T
V
Y
L
V
G
D
T
V
----------------
W
T
S
-
D
-
V
E
-----
K
A
----
L
L
R
F
--
D
P
--
N
V
I
I
-
M
N
T
G
Y
---
A
Q
I
L
G
F--
E
D
S
I
----
I
M
-
G
T
K
D
I
G
R
M
V
V
R
K
P
E
A
----------
K
I
I
A
V
H
M
D
T
V
N
H
T
A
T
S
----
R
K
D
V
R
K
F
I
K
-
G
N
N
I
----
E
S
H
V
A
V
P
E
D
G
E
T
I
T
L
---
39
HHSearch
61.86
25%
-108
- C2 -
2YCB
4
?
A:
[180-382]
-----
A
R
-
L
-
T
A
M
G
G
-----------------
F
R
---------------------
E
V
------------------
G
R
S
C
L
Y
L
Q
----------------
T
-----
P
----
N
S
R
---
V
L
L
D
C
G
V
--------------------------------------------
N
V
--
A
G
-----
G
D
D
K
N
S
Y
PY--------
L
--------
N
---
V
------
P
E
F
---
T
L
-
D
S
-
L
D
A
V
I
I
T
H
A
H
L
D
H
S
G
F
L
-
P
Y
L
Y
H
Y
----------------
G
Y
D
G
P
V
Y
C
-
T
A
P
T
R
D
L
---
M
T
L
L
Q
-----------
L
D
H
I
D
I
A
H
R
E
DEPLPF
N
V
K
H
V
K
K
------------
S
V
K
H
T
-------
I
T
L
D
Y
G
E
-
V
T
-------
D
I
A
P
----
D
I
R
----
L
T
L
H
N
-
A
G
-
H
---------
I
----------
L
G
--------------
S
A
M
-
A
H
L
H
-
I
G
D------------------------------------------------
G
------------------------------------------------
Q
---
H
N
M
V
Y
T
G
D
F
K
----------------
Y
E
Q
-
S
R
L
L
-----
E
A
AANR
F
--
P
--
R
I
--
E
T
L
V
-
M
E
S
T
Y
---
G
G
H
E
D
---
V
Q
P
S
----
R
N
-
R
A
E
K
E
L
V
K
T
I
Y
S
T
L
R
----------
R
G
G
K
I
L
I
P
V
F
A
V
G
R
A
Q
E
L
M
I
V
L
E
E
Y
I
R
T
G
-
I
I
D
E
----
V
P
V
Y
I
D
G
M
I
W
E
A
N
A
I
H
T
A
30
HHSearch
60.26
16%
-99
- C2 -
2WYL
5
ULAG_ECOLI
A:
[45-324]
----------------------------------------------------------------------------
C
T
G
I
W
L
K
----------------
S
-----
E
---
G
G
T
N
---
V
C
V
D
F
W
C
--------------------------------------------
G
T
--
G
K
QSHGN-K---------------
L
QPNLRTT-
P
FVL
D
------
P
-
F
---
A
I
-
R
Q
-
I
D
A
V
L
A
T
H
D
H
N
D
H
I
D
V
--
N
V
A
A
A
V
M
Q
N
------------
C
A
D
D
V
P
F
I
G
-
P
K
T
C
V
D
L
---
W
I
G
W
G
-----------
V
----------------------------------
P
K
E
R
C
-------
I
V
V
K
P
G
D
-
V
V
-------
K
V
-
K
----
D
I
E
----
I
H
A
L
D
-
A
F
-
D
---------
R
GMD-------
D
R
--------------
A
V
N
-
Y
L
F
K
--
T
-------------------------------------------------
P
------------------------------------------------
G
---
G
S
L
Y
H
S
G
D
S
H
----------------
Y
S
N
-
Y
-
Y
A
-----
K
H
----
G
--
N
E
H
Q
I
--
D
V
A
L
-
G
S
Y
G
E
---
N
P
R
-----
G
I
T
D
----
K
M
-
T
S
A
D
M
L
R
M
G
E
A
L
N
A
K
----------
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
----
P
Q
E
I
R
V
L
W
E
-
M
K
K
D
RLKY
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
41
HHSearch
58.96
20%
-111
- C2 -
1QH5
3
GLO2_HUMAN
A:
[1-178]
-----
M
K
-
V
-
E
V
L
P
A
-----------------
L
T
-----------------------------------------
D
N
Y
M
Y
L
V
I
----------------
D
-----
D
E--
T
K
E
A
---
A
I
V
D
P
V
Q
--------------------------------------------
P
Q
K
V
V
D
-----
A
----------------
A
--------
R
---
K
------
H
------
G
-
V
K
-
L
T
T
V
L
T
T
H
H
H
W
D
H
A
G
G
N
-
E
K
L
V
K
L
----------------
E
S
G
L
K
V
Y
G
-
G
D
D
R
I
G
A
---
L
------------------------------------------------------
T
-------
H
K
I
T
H
L
S
-
T
L
-------
Q
V
-
G
----
S
L
N
----
V
K
C
L
A
-
T
P
C
H
---------
T
----------
S
G
--------------
H
I
C
-
Y
F
V
S
-
K
--------------------------------------------------
P
------------------------------------------------
G
GS
E
P
P
A
V
F
T
G
D
T
L
----------------
F
V
A
-
G
-
C
G
-----
K
F
----
Y
---------------
E
G
T
A
-------------------
D
E
-
M
C
K
A
L
L
E
V
L
G
R
L
P
P
D
T
---------
R
V
Y
C
G
H
E
Y
T
I
N
N
L
K
F
A
R
H
V
E
P
G
N
A
A
I
R
E
K
-
L
A
W
A
----
K
E
K
Y
S
I
G
E
P
T
V
P
S
T
L
A
E
E
36
HHSearch
56.42
22%
-93
- C2 -
2XR1
2
?
A:
[184-386]
-----
V
R
-
V
-
T
A
L
G
G
-----------------
C
K
---------------------
E
V
------------------
G
R
S
C
F
L
L
S
----------------
T
-----
P
----
E
S
R
---
I
L
I
D
C
G
V
--------------------------------------------
N
V
--
G
S
-----
D
EN--------------
M
--------
T
---
P
YLYVPE
V
-
F
---
P
L
-
N
Q
-
I
D
A
V
I
V
T
H
A
H
L
D
H
Q
G
L
V
-
P
L
L
F
K
Y
----------------
G
Y
E
G
P
V
Y
C
-
T
P
P
T
R
D
L
---
M
V
L
L
Q
-----------
L
D
Y
I
------------
D
V
A
A
K
E
GKKIPYE
S
G
M
V
A
K
T
L
K
H
T
-------
I
P
L
D
Y
E
E
-
V
T
-------
D
I
A
P
----
D
I
K
----
L
T
F
H
N
-
A
G
-
H
---------
I
----------
L
G
--------------
S
A
I
-
S
H
F
H
I
G
D
-------------------------------------------------
G
------------------------------------------------
L
---
H
N
V
V
F
T
G
D
Y
K
----------------
Y
E
K
-
T
-
R
L
FDPAV
N
K
----
F
--
P
--
R
V
--
E
T
V
I
-
S
E
A
T
Y
---
G
N
A
N
A
---
F
Q
P
A
----
L
K
-
D
A
E
K
H
L
Q
M
V
V
I
A
V
I
P
----------
A
F
A
V
G
R
S
Q
E
V
M
I
V
L
E
E
S
I
R
K
G
L
I
P
E
V
P
V
Y
-
L
D
G
M
----
I
W
E
A
T
A
I
H
A
T
H
P
E
Y
L
N
N
D
35
HHSearch
55.96
17%
-114
- C2 -
3KL7
6
?
A:
[36-213]
---------------------------------------------------------------------------
K
H
G
S
L
M
L
T
----------------
Y
-----
D
----
N
H
S
---
I
Q
V
D
P
V
S
--------------------------------------------
E
Y
--
A
D
-----
Y
--------------------------------------
T
---
T
F
-
P
K
-
A
D
I
I
L
I
T
H
E
H
G
D
H
L
D
P
K
-
A
-
I
Q
A
V
-
E
--------------
K
S
D
T
E
I
I
A
-
N
E
N
S
Q
K
K
---
L
G
K
----------------------------------------------------
G
-------
K
V
L
K
N
G
D
T
D
T
-------
S
I
-
S
----
Y
M
K
----
I
E
A
V
P
-
A
Y
-
N
---------
T
TPGRDKYHPR
H
R
--------------
D
N
G
-
Y
I
L
T
--
F
-------------------------------------------------
D
------------------------------------------------
G
---
L
R
V
Y
I
A
G
D
T
E
----------------
D
I
P
-
E
-
M
------
K
D
----
L
--
K
--
D
I
--
D
I
A
F
-
L
P
V
N
-------------
Q
P
Y
----
T
M
-
T
V
S
Q
A
A
K
A
A
R
M
F
S
P
K
----------
I
L
Y
P
Y
H
Y
G
D
T
K
I
G
E
L
K
D
A
L
K
D
S
G
I
D
V
R
I
R
-
E
L
Q
-----------------------
38
HHSearch
55.57
18%
-99
- C2 -
3AF5
12
?
A:
[190-398]
------
R
-
I
-
T
G
L
G
G
-----------------
F
R
---------------------
E
V
------------------
G
R
S
A
L
L
V
Q
----------------
T
-----
D
----
E
S
F
---
V
L
V
D
F
G
V
--------------------------------------------
N
V
--
A
M
-----
L
ND
P
Y
K
A
----------
F
PHFDA
P
E
F
Q
---
Y
------
V
-
L
---
R
E
-
G
L
-
L
D
A
I
I
I
T
H
A
H
L
D
H
C
G
M
L
-
P
Y
L
F
R
Y
N
---------------
L
F
D
G
P
I
Y
T
-
T
P
P
T
R
D
L
---
M
V
L
L
Q
-----------
K
D
F
I
------------
E
I
Q
Q
S
N
GQDPLYR
P
R
D
I
K
E
V
I
K
H
T
-------
I
T
L
D
Y
G
E
-
V
R
-------
D
I
-
S
P---
D
I
R
----
L
T
L
H
N
-
A
G
-
H
---------
I
----------
L
G
--------------
S
A
I
-
V
H
L
H
-
I
G
-------------------------------------------------
N
G-----------------------------------------------
L
---
H
N
I
A
I
T
G
D
F
K
----------------
F
I
P
-
T
-
R
L
L----
E
P
ANAK
F
--
P
--
R
L
--
E
T
L
V
-
M
E
S
T
Y
---
G
G
A
N
D
---
I
Q
M
P
----
R
E
-
E
A
E
K
R
L
I
E
V
I
H
N
T
I
K
----------
R
G
G
K
V
L
I
P
A
M
A
V
G
R
A
Q
E
V
M
M
V
L
E
E
Y
A
R
I
G
-
G
I
E
V
----
P
I
Y
L
D
G
M
I
W
E
A
T
A
I
H
T
A
Y