@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0452: (2015-12-01 )
MKTIKDWQINICLATYNGQKYLRQQLDSIIQQGYTNWTCLIRDDGSTDDTVAIIKEYVNRDSRFIFINSNDDRKLGSHRSFYELVNYKKADFYVFSDQDDVWKENRLERYLEEAEKFNQELPLLVYSNWTSVDEKLTVLKEHNPATVIQEQIAFNQINGMVIMMNHELAKLWEYRQIGAHDSYVGTLAYAVGNVAYISDSTVLWRRQVGAESLNNYGRQYGVATFWQMINTSFDRASLIFAQVSDKMSLERKLFFSRFIELKNANLIRRIYLLSKLKLRRKSLKETVAMTILLLTGYGKPKA
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.-....----------------...-20........-------30.-...--.--...40--.....---------..-..50.-......---------..60....------..------..70..-------.--------......80.-----.....------..---90.....-...100-..-.....110.......120.-......130...-------..---------------..140--------.---------------------------------..---------------.--.----.---------.-------150.......160......---.170-----.---..--.---.---..180.......190.-.-......200...-....210.......220.......230.-......-240.......250.---......260------.......--.---.270.......280---.........290.......300----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKT
I
K
D
W
Q
I
N
I
C
-
L
A
TY----------------N
G
Q
-
K
Y
L
R
Q
Q
L
D
S
I
-------
I
Q
Q-GYT--
N
--
W
T
C
L
---
I
RDDG---------ST-D
D
T
-
V
-
A
I
I
K
E
Y
---------VNRDS
R
F
I
------
F
I
------NSN-DD-------R--------KLGS
H
R
S
F
Y
-----
E
L
VNY------KK---A
D
F
Y
V
FS-DQ
D
D
V
W
-
K
E
-
N
R
L
E
R
Y
L
E
E
A
E
K
F
N
QEL
P
L
-
L
V
YSNWTS
V
D
E
K
-------
L
T
---------------
V
L
KEH--------N---------------------------------
P
A
---------------
T
--
V
----
I
---------
Q
-------
E
Q
I
A
FNQIN
G
M
V
I
M
MN
H
E
L
---
A
K
L
W
-----
E
---
Y
R
--Q---I---GAHD
S
Y
V
G
T
L
A
Y
A
-VG-
N
-
V
A
Y
ISDS
T
V
L
W
R
-
R
QV
G
A
E
S
L
N
N
Y
G
R
Q
Y
G
V
A
T
F
W
Q
M
I
NTSF-D
R
A
S
L
I
-
F
A
QVS
D
K
M
S
L
E
R
K
L
---
F
F
S
R
F
I
E
--------LKN
A
N
L
I
--
R
---
R
I
Y
L
L
S
K
L
K
L
R
R
-----
K
S
L
K
E
T
V
A
M
T
I
L
L
L
TGYGKPKA----------------------------------------------------------------------------------------
54
Fugue
81.38
19%
-73
- C4 -
2Z86
4
CHS_ECOLX
A:
[4-625]
IDID
A
A
T
K
I
M
C
S
N
A
KA
I
S
L
N
E
V
E
K
N
E
I
I
S
K
Y
R
E
I
T
A
K
K
S
E
R
A
E
L
K
EVEPIPLDWPSDLTLPPLPESTND
Y
V
W
A
G
K
RKELLIID
G
L
S
I
V
I
P
T
YNR
A
K
I
L
A
I
T
L
A
C
L
C
N
QKTI
Y
D
Y
E
V
I
V
A
D
DGSKEN
I
E
E
I
V
R
E
F
E
SLLN
I
K
Y
V
R
Q
K
D
YGYQ
L
C
A
V
R
N
L
G
L
R
A
AKYN
Y
V
A
I
L
D
CD
M
A
P
N
PL
W
V
Q
S
Y
M
E
L
L
A
V
DDN
V
A
L
I
G
P
R
K
Y
I
D
TSKHT
Y
L
D
F
L
S
Q
KSLINEIPESVDWR
I
E
H
F
K
N
T
D
NLRLCNTPFRFFSGG
N
V
A
F
A
K
K
W
L
F
R
A
GWFDEEFTHWGG
E
D
N
E
F
G
Y
R
L
Y
R
E
G
C
Y
F
R
S
V
EGA
M
A
Y
H
Q
E
P
PQLLQQKVPYFYRKKEKIES
A
T
L
K
R
V
P
L
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
------
S
Q
K
-
N
K
------------------
G
I
G
S
A
S
N
-----
T
A
V
R
L
------
C
R
---
G
F
Y
I
G
Q
L
-
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
F
R
K
-
D
L
S
L
A
C
-
V
Y
T
T
N
R
N
I
D
R
E
G
-------
N
L
---------------
I
S
N
G
Y
--------
N
---------------------------------
W
P
---------------
I
--
Y
----
S
---------
R
-------
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
-----
N
---
E
S
--
I
---
S
---
N
A
V
D
Y
D
M
Y
L
K
L
S
E
-
V
G
-
P
-
F
K
H
I
N
K
I
C
Y
N
R
V
-
L
H
S
---------------------
I
K
K
L
-
D
I
Q
K
E
N
-
H
F
K
V
V
N
E
S
L
S
R
L
G
I
---
K
K
Y
K
Y
S
P
--------
L
T
N
L
N
E
C
--
R
---
K
Y
T
W
E
K
I
------------------------------------------------------------------------------------------------------------------------
53
Fugue
80.21
17%
-59
- C4 -
1QG8
2
SPSA_BACSU
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
Q
S
DISG
V
K
E
-
R
T
-------
E
--------
K
T
R
Y
A
A
L
I
N
-----
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
--
K
A
-
V
I
Y
S
A
S
K
T
Y
H
L
N
-------
D
I
---------------
V
K
E
T
V
--------
R
---------------------------------
P
A
---------------
A
--
Q
--------------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
-----------------------------------------------
P
A
F
Y
R
I
G
-
D
A
R
F
F
W
-
R
V
N
H
F
Y
P
F
Y
P
L
D
E
E
---
L
D
L
N
Y
I
T
--------
E
F
V
R
N
L
P
--
P
---
Q
----
R
N
C
R
E
L
R
-----
E
S
L
K
K
L
---------
G
M
G
--------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.55
31%
-100
- C4 -
2Z86
2
CHS_ECOLX
A:
[377-496]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
L
S
R
-
L
G
I
K
K
Y
-
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
---
T
W
E
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.44
31%
-97
- C4 -
2Z86
2
CHS_ECOLX
D:
[377-496]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
-
Y
K
Y
S
P
L
-
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.91
31%
-101
- C4 -
2Z86
2
CHS_ECOLX
C:
[377-496]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
G
E
N
T
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
-
S
L
S
R
L
G
-
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
---
C
R
K
Y
T
W
E
--------
K
I
------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.80
31%
-92
- C4 -
2Z87
2
CHS_ECOLX
B:
[376-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
N
T
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
L
-
S
R
L
G
I
K
-
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
---
K
Y
T
W
E
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
72.52
31%
-99
- C4 -
2Z86
2
CHS_ECOLX
B:
[377-496]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
G
N
T
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
-
L
S
R
L
G
I
-
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
---
R
K
Y
T
W
E
K
--------
I
-------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.30
31%
-98
- C4 -
2Z87
2
CHS_ECOLX
A:
[376-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
-
I
P
A
Y
----------------
N
C
S
-
K
Y
I
V
R
C
V
E
S
A
-------
L
N
Q
-
T
I
T
--
D
--
L
E
V
C
---
I
C
D
D
G
---------
S
T
-
D
D
T
-
L
-
R
I
L
Q
E
H
---------
Y
A
N
H
P
R
V
R
------
F
I
-------
S
Q
-
K
N
-------
K
--------
G
I
G
S
A
S
N
-------
T
A
V
R
L
------
C
R
---
G
-
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
-
D
A
V
E
L
C
L
D
E
---
F
R
K
D
L
S
L
A
C
V
Y
T
T
N
R
N
I
D
R
E
-------
G
N
---------------
L
I
S
N
G
--------
Y
---------------------------------
N
W
---------------
P
--
I
----
Y
---------
S
-------
R
E
K
L
T
S
A
M
I
C
H
H
F
R
M
F
T
A
R
---
A
W
N
L
-----
T
---
E
G
--
F
---
N
---
E
S
I
S
N
A
V
D
Y
D
M
Y
L
-
K
L
-
S
-
E
V
G
P
F
K
H
I
N
K
I
C
-
Y
N
R
V
L
H
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
L
S
R
-
L
G
I
K
K
Y
-
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
---
T
W
E
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
72.28
12%
-54
- C4 -
1XHB
4
GALT1_MOUSE
A:
[8-466]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
S
L
P
D
V
R
L
E
G
C
-
K
T
K
V
Y
P
D
NL
P
T
T
S
V
V
I
V
F
H
N
E
A
W
-
S
T
L
L
R
T
V
H
S
V
-------
I
N
R
-
S
P
R
--
H
MI
E
E
I
V
---
L
V
D
D
A
---------
S
E
-
R
D
F
-
L
K
R
P
L
E
S
Y
---------
V
K
K
L
K
V
P
V
------
H
V
------
I
R
M
-
E
Q
-------
R
--------
S
-
G
L
I
R
A
R
L
-----
K
G
A
A
V
------
S
R
---
G
Q
V
I
T
F
L
-
D
A
H
C
E
C
-
T
A
-
G
W
L
E
P
L
L
A
R
I
K
H
D
R
R
T
V
V
C
-
P
I
I
D
V
I
S
D
D
T
F
E
-------
Y
M
A
G
S
DM
T
Y
G
G
F
N
WKL
N
F
R
W
Y
P
--------
V
---------------------------------
P
Q
---------------
R
--
E
----
M
---------
D
R
R
KGDRT
L
P
V
R
T
P
T
M
A
G
G
L
F
S
I
D
R
D
Y
---
F
Q
E
I
GTYDA
G
---
M
D
--
I
---
W
---
G
G
E
N
L
E
I
S
F
R
I
W
Q
-
C
G
G
T
-
L
E
I
V
T
C
S
H
V
G
H
V
-
F
G
Q
I
I
N
K
N
N
R
R
L
A
E
V
W
M
D
E
F
K
N
F
F
Y
I
I
S
-
P
G
V
T
K
V
D
Y
G
D
I
S
S
R
L
G
L
R
R
K
L
QCK
P
F
S
W
Y
L
E
--------
N
I
Y
P
D
S
Q
IP
R
---
H
Y
F
S
L
G
E
I
R
N
V
E
TN
Q
C
L
D
N
M
A
R
K
E
N
E
K
V
G
I
F
N
C
H
G
M
G
G
N
QVFSYTANKEIRTDD
L
C
L
D
V
S
K
LN
G
P
V
T
M
L
KCHHLKGNQ
L
W
E
Y
D
PVKLTLQHVNSN
Q
C
L
D
K
A
TEEDSQ
V
P
S
I
R
DCTGSRSQQWLLRNV
28
HHSearch
69.49
12%
-87
* C4 *
2D7I
5
GLT10_HUMAN
A:
[109-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
P
N
T
S
I
I
-
I
P
F
H
----------------
N
E
G
W
S
S
L
L
R
T
V
H
S
V
-------
L
N
R
-
S
P
P
EL
V
--
A
E
I
V
---
L
V
D
D
F
---------
S
D
-
R
E
H
L
K
-
K
P
L
E
D
Y
---------
M
A
L
F
P
S
V
R
------
I
L
-------
R
--
T
K
-------
K
--------
R
E
G
L
I
R
T
R
M
-----
L
G
A
S
V
------
A
T
---
G
D
V
I
T
F
L
-
D
S
H
C
E
A
-
N
V
-
N
W
L
P
P
L
L
D
R
I
A
R
---
N
R
K
T
-
I
V
C
P
M
I
D
V
I
D
H
D
-------
D
F
---------------
R
Y
E
T
Q
AGD
A
M
R
G
A
F
---------------------------------
D
W
EMY
Y
K
R
I
P
IPPELQK
A
--
D
----
P
---------
S
-------
D
P
F
E
S
P
V
M
A
G
G
L
F
A
V
D
R
K
W
---
F
W
E
L
-----
G
GY-
D
P
--
G
---
L
EIW
G
G
E
Q
Y
E
I
S
F
K
V
W
M
-
C
G
G
R
-
M
E
D
I
P
C
S
R
V
G
H
I
-
Y
R
K
Y
V
P
Y
K
V
P
A
G
V
S
L
A
R
N
L
K
R
V
A
E
V
W
M
D
-
E
Y
A
E
Y
I
-
Y
Q
R
R
P
E
Y
R
H
L
S
A
G
D
---
V
A
V
Q
K
K
L
--------
R
S
S
L
N
C
K
--
S
---
F
K
W
F
M
T
K
I
A
W
D
L
-----
P
K
F
Y
P
P
V
E
P
P
A
A
A
W
G
E
I
R
N
V
G
T
----------------------------------------------------------------------------------------
61
Fugue
67.91
14%
-32
- C4 -
3CKJ
5
GPGS_MYCPA
A:
[15-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRDTRPG
D
T
W
L
ADR
S
W
N
R
P
GWT
V
A
E
L
E
A
A
K
A
G
R
T
I
S
V
V
-
L
P
A
L
----------------
D
E
E
-
D
T
I
G
S
V
I
D
S
I
-------
S
P
L
V
D
G
L
--
V
--
D
E
L
I
---
V
L
D
S
G
---------
S
T
-
D
D
T
-
E
-
I
R
A
V
A
A
---------
G
A
R
V
V
S
R
E
------
Q
A
------
L
P
E
-
V
P
-------
I
--------
R
P
G
K
G
E
A
L
W
-----
R
S
L
A
A
------
S
R
---
G
D
I
V
V
F
V
-
D
S
D
-------------
L
I
N
P
H
P
--
M
F
V
P
W
-
L
V
G
P
L
L
T
G
D
G
V
H
-------
L
V
---------------
K
S
F
Y
R
--------
R
---------------------------------
P
G
---------------
R
--
V
----
T
---------
E
-------
L
V
-----
A
R
P
L
L
A
A
L
R
P
E
L
---
G
C
------------------------
I
L
Q
P
L
G
G
E
Y
A
A
T
------
R
E
L
L
T
S
V
P
F
A
P
G
-
Y
G
V
E
I
G
L
L
V
D
T
F
D
R
L
G
L
D
A
I
A
Q
V
N
L
G
V
R
-
E
H
R
N
R
P
-
L
A
E
L
G
A
M
S
R
Q
V
I
A
T
---
L
L
S
R
C
G
I
--------
P
D
S
G
V
G
L
--
T
---
Q
F
V
A
D
G
P
E
G
Q
S
Y
-----
T
Q
H
T
W
P
V
S
L
A
D
R
P
P
M
Q
A
I
R
P
R
-----------------------------------------------------------------------------------------
33
HHSearch
65.35
16%
-80
- C4 -
3CKJ
5
GPGS_MYCPA
A:
[44-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
A
G
R
T
I
S
V
V
-
L
P
A
L
----------------
D
E
E
-
D
T
I
G
S
V
I
D
S
I
-------
S
P
L
-
V
D
G
L-
V
--
D
E
L
I
---
V
L
D
S
G
---------
S
T
-
D
D
T
-
E
-
I
R
A
V
A
A
--------------
G
A
R
------
V
V
-------
S
--
R
E
QALPE
V
P
I
--------
R
P
G
K
G
E
A
L
W
-----
R
S
L
A
A
------
S
R
---
G
D
I
V
V
F
V
-
D
S
D
L
I
N
P
H
P
-
M
F
V
P
W
L
V
G
P
L
L
T
G
--
D
G
V
H
-
L
V
K
S
F
Y
R
R
P
--------------------------------G
R
V
T
E
L
V
A
R
---------------------------------
P
L
---------------
L
A
A
L
----
R
---------
P
-------
E
L
G
C
I
L
Q
P
L
G
G
E
Y
A
A
T
R
E
L
---
L
T
S
V
-----
P
F
--
A
P
------
G
---
Y
G
V
E
I
G
L
L
V
D
T
F
D
R
L
G
L
D
A
I
A
Q
V
N
L
G
V
R
E
H
R
-
N
R
P
L
A
E
L
G
A
M
S
R
Q
V
I
A
T
L
L
S
R
C
G
I
P
D
S
G
-
V
G
L
T
Q
F
-
V
A
D
G
P
E
G
Q
S
Y
T
Q
H
T
---
W
P
V
S
L
A
D
--------
R
P
P
M
Q
A
I
--
R
---
P
R
-----------------------------------------------------------------------------------------------------------------------------
37
HHSearch
63.94
12%
-62
- C4 -
3ZF8
2
MNN9_YEAST
A:
[21-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
N
K
E
H
I
L
I
L
-
T
P
M
Q
----------------
T
----
F
H
Q
Q
Y
W
D
N
L
-------
L
Q
L
-
N
Y
P
--
R
--
E
L
I
E
L
G
F
I
T
P
R
T
---------
A
T
G
D
L
A
-
L
-
K
K
L
E
N
A
I
K
K
V
Q
T
DKK
T
Q
R
F
S
K
I
T
------
I
L
-------
R
--
Q
N
-------
S
A
L
D
V
Q
K
E
R
R
A
A
M
A
L
A
R
N
-----
E
L
L
F
S
------
T
I
GPH
T
S
W
V
L
W
L
-
N
A
D
I
I
E
-
T
P
P
S
L
I
Q
D
M
T
K
H
--
N
-----
K
A
-
I
L
A
A
N
I
Y
Q
R
F
Y
D
EEKK
Q
P
S
I
R
P
Y
D
FN
N
---------
W
Q
E
S
D
--------
T
G
L
E
I
A
S
Q
MGDD
E
I
I
V
EGYAEIATYRPLMAHFYD
A
N
---------------
G
--
V
----
P
---------
G
-------
E
E
M
A
L
D
G
V
G
G
G
C
T
L
V
K
A
E
V
---
H
R
D
G
-----
A
MF-
P
N
--
F
PFY
H
---
L
I
E
T
E
G
F
A
K
M
A
K
R
-
L
N
Y
D
-
V
F
G
L
P
N
Y
L
V
Y
H
I
-
E
E
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
63.19
18%
-60
- C2 -
4OCV
6
?
A:
[24-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
N
E
A
L
F
D
V
A
S
H
FALEGTVD
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
V
T
T
----------------
D
G
P
-
R
Y
I
L
Q
R
M
N
T
G
IFPD
T
V
N
L
M
R
-
N
V
E
--
L
--
V
T
S
T
---
L
K
A
Q
G
KE
T
L
D
I
V
R
T
T
S
-
G
D
T
-
W
-
A
E
I
D
G
G
---------
A
W
R
V
Y
K
F
I
EH
T
M
S
Y
N
L
------
V
P
N
-
P
D
-------
V
--------
F
R
E
A
G
R
A
F
G
-----
D
F
Q
N
F
L
S
G
FDA
N
Q
---
L
T
E
T
I
A
H
-
F
H
D
T
P
H
-
R
F
-
E
D
F
K
K
A
L
A
A
D
E
L
G
R
A
A
G
C
G
-
P
E
I
E
F
Y
L
S
H
A
D
Q
-------
Y
A
---------------
V
V
M
D
G
--------
L
---------------------------------
R
D
---------------
G
--
S
----
I
---------
P
-------
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
---
G
K
A
R
-----
A
---
I
-------
I
---
D
L
D
T
I
M
P
G
S
M
L
F
D
-
F
G
-
D
-
S
I
R
F
G
A
S
T
A
L
E
D
E
R
D
L
D
K
V
H
F
S
T
E
L
F
R
A
Y
T
E
G
F
V
G
E
L
R
D
S
I
T
A
R
E
A
E
L
-
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
--
F
L
A
D
Y
L
E
GDVYFATK
Y
P
E
H
N
L
V
--
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
-----
D
E
T
R
A
I
V
A
D
V
M
E
T
T
------------------------------------------------------------------------------------------------
25
HHSearch
61.99
14%
-32
- C4 -
3BCV
-
?
A:
[3-218]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
K
V
S
V
I
-
V
P
I
Y
----------------
N
V
E
-
K
Y
L
D
Q
C
V
Q
A
L
-------
L
A
Q
-
T
L
S
--
D
--
I
E
I
I
---
L
I
D
D
E
---------
S
P
-
D
N
C
-
P
-
K
I
C
D
D
Y
---------
A
A
Q
Y
P
N
I
K
------
V
I
----------
H
K
-------
K
--------
N
A
G
L
G
M
A
C
N
-----
S
G
L
D
V
------
A
T
---
G
E
Y
V
A
F
C
-
D
S
D
D
Y
V
-
D
S
-
D
M
Y
M
T
M
Y
N
V
A
Q
K
---
Y
T
C
D
-
A
V
F
T
-------------------------------------FKLY----
K
---------------------------------
N
K
---------------
N
--
E
I
H
T
L
L
KDLIASD
P
Y
A
-------
R
E
E
R
A
I
Q
V
S
A
K
V
V
L
Y
R
R
N
L
---
I
E
K
K
-----
H
L
R
F
V
S
ER
I
---
L
---
P
S
E
D
L
I
F
N
V
D
V
L
A
-
N
S
N
I
-
V
C
V
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.81
19%
-99
- C4 -
1QG8
-
SPSA_BACSU
A:
[2-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
------
Q
S
D
I
S
G
-------
V
--------
K
E
R
T
E
K
T
R
Y
A
A
L
I
N
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
K
A
V
I
-
Y
S
A
S
K
T
Y
H
L
N
----------
D
---------------
I
V
K
E
T
--------
V
---------------------------------
R
P
---------------
A
--
A
----
Q
---------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
P
A
F
Y
R
I
G
-
D
A
-
R
-
F
F
W
R
V
N
H
F
Y
P
F
Y
-
P
L
D
E
E
L
D
L
N
Y
I
T
E
F
V
R
N
L
P
P
Q
R
N
C
R
E
L
R
-
E
S
L
K
K
L
-
G
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.77
19%
-101
- C4 -
1QGS
2
SPSA_BACSU
A:
[2-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
------
Q
S
D
I
S
G
-------
V
--------
K
E
R
T
E
K
T
R
Y
A
A
L
I
N
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
K
A
V
I
-
Y
S
A
S
K
T
Y
H
L
N
----------
D
---------------
I
V
K
E
T
--------
V
---------------------------------
R
P
---------------
A
--
A
----
Q
---------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
P
A
F
Y
R
I
G
-
D
A
-
R
-
F
F
W
R
V
N
H
F
Y
P
F
Y
-
P
L
D
E
E
L
D
L
N
Y
I
T
E
F
V
R
N
L
P
P
Q
R
N
C
R
E
L
R
-
E
S
L
K
K
L
-
G
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.38
19%
-98
- C4 -
1QGQ
2
SPSA_BACSU
A:
[2-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
------
Q
S
D
I
S
G
-------
V
--------
K
E
R
T
E
K
T
R
Y
A
A
L
I
N
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
K
A
V
I
-
Y
S
A
S
K
T
Y
H
L
N
----------
D
---------------
I
V
K
E
T
--------
V
---------------------------------
R
P
---------------
A
--
A
----
Q
---------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
P
A
F
Y
R
I
G
-
D
A
-
R
-
F
F
W
R
V
N
H
F
Y
P
F
Y
-
P
L
D
E
E
L
D
L
N
Y
I
T
E
F
V
R
N
L
P
P
Q
R
N
C
R
E
L
R
-
E
S
L
K
K
L
-
G
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.49
19%
-98
- C4 -
1H7L
2
SPSA_BACSU
A:
[2-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
------
Q
S
D
I
S
G
-------
V
--------
K
E
R
T
E
K
T
R
Y
A
A
L
I
N
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
K
A
V
I
-
Y
S
A
S
K
T
Y
H
L
N
----------
D
---------------
I
V
K
E
T
--------
V
---------------------------------
R
P
---------------
A
--
A
----
Q
---------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
P
A
F
Y
R
I
G
-
D
A
-
R
-
F
F
W
R
V
N
H
F
Y
P
F
Y
-
P
L
D
E
E
L
D
L
N
Y
I
T
N
E
F
V
R
N
L
P
P
Q
R
N
C
R
E
L
-
R
E
S
L
K
K
-
L
G
M
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.21
19%
-97
- C4 -
1H7Q
3
SPSA_BACSU
A:
[2-140]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
-
M
T
S
Y
----------------
N
K
S
-
D
Y
V
A
K
S
I
S
S
I
-------
L
S
Q
-
T
F
S
--
D
--
F
E
L
F
---
I
M
D
D
N
---------
S
N
-
E
E
T
-
L
-
N
V
I
R
P
F
---------
L
N
-
D
N
R
V
R
------
F
Y
------
Q
S
D
I
S
G
-------
V
--------
K
E
R
T
E
K
T
R
Y
A
A
L
I
N
Q
A
I
E
M
------
A
E
---
G
E
Y
I
T
Y
A
-
T
D
D
N
I
Y
-
M
P
-
D
R
L
L
K
M
V
R
E
L
D
T
H
P
E
K
A
V
I
-
Y
S
A
S
K
T
Y
H
L
N
----------
D
---------------
I
V
K
E
T
--------
V
---------------------------------
R
P
---------------
A
--
A
----
Q
---------
V
-------
T
W
N
A
P
C
A
I
D
H
C
S
V
M
H
R
Y
S
V
---
L
E
K
V
-----
K
---
E
K
--
F
---
G
---
S
Y
W
D
E
S
P
A
F
Y
R
I
G
-
D
A
-
R
-
F
F
W
R
V
N
H
F
Y
P
F
Y
-
P
L
D
E
E
L
D
L
N
Y
I
T
D
N
E
F
V
R
N
L
P
P
Q
R
N
C
R
E
-
L
R
E
S
L
K
-
K
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------