@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0486: (2015-12-01 )
MSHKEIGHQFLARLGKKRLRPGGVQATNWLIKKGHFSADSRVLEVACNQCTSSIDIAKAFSCHITALDLDSKVIEKAKENVKKAQLEEFIEVIQGNALKLPFPDNSFDIVINEAMLTMLSNSAKEKAIKEYLRVLKPGGCLLTHDVSYQDEDTAKLIDQLRHTINVNVAPLKIDDWQNLFLQNGFSSSEYQFGKMSLMSPLGMIKDEGLFNTIKIISRGLKKENRSQFLKMKHFFTKTGKNLCYIAVASTK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30..-...-...40........50........-60-.-....---....70.......-.80........90........100.......110.......120.......130.......140.----..-----.-----..-.150----.....-.-------.160..-------.-----....170.......180.......190.......200.......210.......220.....-..230.....--..240.......250--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
H
K
E
I
G
H
Q
F
L
A
R
L
G
K
K
RLRPGGVQAT
N
W
L
I
KK-GHF-SAD
S
R
V
L
E
V
A
C
N
QCTSSI
D
I
A
K
A
-
F
--
S
-
C
H
I
T
---
A
LDL
D
S
K
V
I
E
K
A
K
-
E
N
V
K
K
A
Q
L
E
E
F
I
E
V
IQGN
A
L
KLPFPDNS
F
D
I
V
I
N
E
A
M
L
T
M
L
SN
S
A
K
E
K
A
I
K
E
Y
L
R
VLKPG
G
C
L
L
T----HD-----V-----SY-QD
E
D
----
T
A
K
L
I
-
D
-------
Q
L
R
H
T
I
-------N-----V
N
V
A
P
L
K
ID
D
W
Q
N
L
F
L
QNGFSSSEYQFG
K
M
S
L
MSPLGMIKDE
G
L
F
N
T
I
K
I
I
S
R
G
LK
K
E
N
R
S
Q
-
F
L
K
M
K
H
F
F
T
K--TGK
N
L
C
Y
I
A
VASTK---
53
HHSearch
78.61
17%
-75
- C2 -
3UJC
1
?
A:
[31-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
N
Y
I
S
S
G
G
L
E
A
T
K
K
I
L
S
D
-
I
E
L
-
N
E
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
M
Y
I
N
E
K
-
Y
--
G
-
A
H
T
H
---
G
I
D
I
C
S
N
I
V
N
M
A
N
-
E
R
V
S
G
N
---
N
K
I
I
F
E
A
N
D
I
L
T
K
E
F
P
E
N
N
F
D
L
I
Y
S
R
D
A
I
L
A
L
S
L
E
N
K
N
K
L
F
Q
K
C
Y
K
W
L
K
P
T
G
T
L
L
I
----
T
D
-----
Y
-----
C
A
-
T
E
K
E
------
N
W
D
-
D
-------
E
F
K
E
Y
V
K
------
Q
-----
R
K
Y
T
L
I
T
V
E
E
Y
A
D
I
L
T
A
C
N
F
K
N
V
V
S
K
D
L
S
D
Y
W
N
Q
L
L
E
V
E
H
K
Y
L
H
-
E
N
K
E
E
F
L
K
L
F
S
E
K
K
F
I
S
L
D
D
G
W
S
R
K
I
K
D
S
-
K
R
K
M
Q
R
W
G
Y
F
K
A
T
K
---
61
HHSearch
78.02
25%
-92
- C2 -
1XXL
3
YCGJ_BACSU
A:
[13-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
T
-
A
E
C
-
R
A
E
H
R
V
L
D
I
G
A
G
A
G
H
T
A
L
A
F
S
P
Y
-
V
----
Q
E
C
I
---
G
V
D
A
T
K
E
M
V
E
V
A
S
-
S
F
A
Q
E
K
G
V
-
E
N
V
R
F
Q
Q
G
T
A
E
S
L
P
F
P
D
D
S
F
D
I
I
T
C
R
Y
A
A
H
H
F
S
--
D
V
R
K
A
V
R
E
V
A
R
V
L
K
Q
D
G
R
F
L
L
----
V
D
-----
H
-----
Y
A
-
P
E
D
P
V
---
L
D
E
F
V
-
N
-------
H
L
N
R
L
R
D
------
P
-----
S
H
V
R
E
S
S
L
S
E
W
Q
A
M
F
S
A
N
Q
L
A
Y
Q
D
I
Q
K
W
N
L
P
I
Q
Y
D
S
W
I
K
R
G
G
T
P
A
D
R
E
K
Q
I
I
T
H
L
N
H
A
S
D
E
A
-
R
D
T
F
C
I
T
L
N
Q
--
N
G
Q
P
I
S
F
C
L
K
A
I
L
I
---
62
HHSearch
77.93
23%
-96
- C2 -
3DLC
4
?
A:
[27-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
Y
P
I
I
A
E
N
I
I
N
R
-
F
G
I
-
T
A
-
G
T
C
I
D
I
G
S
G
P
G
A
L
S
I
A
L
A
K
Q
-
S
--
D
-
F
S
I
R
---
A
L
D
F
S
K
H
M
N
E
I
A
L
-
K
N
I
A
D
A
N
L
N
D
R
I
Q
I
V
Q
G
D
V
H
N
I
P
I
E
D
N
Y
A
D
L
I
V
S
R
G
S
V
F
F
W
--
E
D
V
A
T
A
F
R
E
I
Y
R
I
L
K
S
G
G
K
T
Y
I
----
G
G
-----
G
-----
F
G
-
N
K
E
L
----
R
D
S
I
S
-
A
E
M
I
R
K
NP
D
W
K
E
F
N
-------
R
-----
K
N
I
S
Q
E
N
V
E
R
F
Q
N
V
L
D
E
I
G
I
S
S
Y
E
I
I
L
G
D
E
G
F
W
I
I
I
S
K
T
D
Q
E
V
I
------------------------------------------------
19
PsiBlast_PDB
77.44
27%
-81
- C2 -
1XXL
3
YCGJ_BACSU
A:
[14-172]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
T
-
A
E
C
-
R
A
E
H
R
V
L
D
I
G
A
G
A
G
H
T
A
L
----
A
-
F
--
S
-
P
Y
V
Q
E
C
I
G
V
D
A
T
K
E
M
V
E
V
A
S
-
S
F
A
Q
E
K
G
V
E
N
-
V
R
F
Q
Q
G
T
A
E
S
L
P
F
P
D
D
S
F
D
I
I
T
C
R
Y
A
A
H
H
F
S
D
V
--
R
K
A
V
R
E
V
A
R
V
L
K
Q
D
G
R
F
L
L
----
V
D
-----------
H
Y
-
A
P
E
D
------
P
V
L
-
D
-------
E
F
V
N
H
L
-------
N
R
L
R
D
P
S
H
V
R
E
S
S
L
S
E
W
Q
A
M
F
S
A
N
Q
L
A
Y
Q
D
I
Q
K
W
N
L
P
I
Q
Y
D
S
W
I
K
R
G
G
T
P
A
D
R
E
K
Q
I
I
T
H
L
N
H
A
S
D
E
A
-
R
D
T
F
C
I
T
L
N
Q
--
N
G
Q
P
I
S
F
C
L
K
A
I
L
I
---
1
PsiBlast_PDB
74.88
29%
-111
- C2 -
3MGG
-
?
A:
[33-166]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
P
P
G
A
K
V
L
E
A
G
C
G
I
G
A
Q
T
V
I
L
A
K
N
N
P
--
D
-
A
E
I
T
---
S
I
D
I
S
P
E
S
L
E
K
A
R
-
E
N
T
E
K
N
G
I
K
N
-
V
K
F
L
Q
A
N
I
F
S
L
P
F
E
D
S
S
F
D
H
I
F
V
C
F
V
L
E
H
L
--
Q
S
P
E
E
A
L
K
S
L
K
K
V
L
K
P
G
G
T
I
T
V
I
E
G
D
H
G
-----
S
-----
C
Y
-
F
H
P
E
----
G
K
K
A
I
-
E
-------
A
W
N
C
L
I
-------
R
-----
V
Q
A
Y
M
K
G
N
S
L
V
G
R
Q
I
Y
P
L
L
Q
E
S
G
F
E
K
I
R
V
E
P
R
M
V
Y
I
D
S
S
K
P
E
L
V
D
G
F
I
L
K
T
I
I
P
M
V
E
G
V
K
E
Q
-
S
L
K
M
Q
I
I
K
E
E
--
E
W
E
K
G
I
E
E
L
H
K
T
A
E
---
69
HHSearch
74.83
26%
-82
- C2 -
3MGG
-
?
A:
[33-201]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
P
P
G
A
K
V
L
E
A
G
C
G
I
G
A
Q
T
V
I
L
A
K
N
-
N
--
P
D
A
E
I
T
---
S
I
D
I
S
P
E
S
L
E
K
A
R
-
E
N
T
E
K
N
G
I
-
K
N
V
K
F
L
Q
A
N
I
F
S
L
P
F
E
D
S
S
F
D
H
I
F
V
C
F
V
L
E
H
L
Q
--
S
P
E
E
A
L
K
S
L
K
K
V
L
K
P
G
G
T
I
T
V
----
I
E
-----
G
-----
D
H
-
G
S
C
Y
F
H
PE
G
K
K
A
I
-
E
-------
A
W
N
C
L
I
R
V
Q
A
---
Y
-----
M
K
G
N
S
L
V
G
R
Q
I
Y
P
L
L
Q
E
S
G
F
E
K
I
R
V
E
P
R
M
V
Y
I
D
S
S
K
P
E
L
V
D
G
F
I
L
K
T
I
I
P
M
V
E
G
V
K
E
Q
S
L
K
M
-
Q
I
I
K
E
E
E
W
E
K
--
G
I
E
E
L
H
K
T
A
E
H
G
G
T
---
82
Fugue
73.36
14%
-64
- C2 -
4KRI
2
?
C:
[1-433]
ASMP
A
V
E
R
Q
L
I
E
C
L
H
H
V
IKGAEPQ
Q
V
G
I
L
C
PQ
D
D
Q
R
K
A
L
T
E
Q
FGSK
T
A
T
S
F
C
KEVDSLKNLSNLD
A
L
I
V
N
QAL
D
E
E
I
N
D
S
E
K
L
D
K
F
I
T
A
A
L
R
S
LRTD
G
V
L
I
L
R
Q
D
LSKVKEMK
K
M
A
M
L
T
D
Y
F
D
V
F
R
L
E
E
GN
G
N
V
G
F
Q
F
Y
AVNEV
L
D
S
V
Y
VHQNWLD
F
I
W
T
L
M
K
K
P
F
PVS
F
R
D
F
L
D
R
T
Q
Y
T
D
T
G
I
F
A
Y
E
W
I
F
G
N
N
F
I
S
P
G
G
W
N
Q
N
L
A
I
L
K
R
F
G
P
M
-
K
T
G
Q
R
M
L
D
I
G
V
G
I
G
G
G
A
R
Q
A
A
S
E
-
F
--
G
-
L
Q
V
H
---
G
V
D
L
S
T
N
M
L
A
V
A
L
-
E
R
V
H
K
E
K
D
A
R
-
V
T
Y
A
V
C
D
A
C
E
Y
E
F
E
P
N
S
F
D
Y
V
F
S
R
D
C
I
Q
H
I
K
D
--
T
D
K
L
F
S
R
I
Y
R
A
L
K
P
G
G
K
V
L
I
----
T
M
-----
Y
-----
G
V
-
G
H
G
T
----
L
S
E
S
F
-
K
-------
E
Y
V
S
Q
R
-------
Q
-----
Y
Y
L
K
N
--
L
E
Q
I
E
E
I
A
K
K
T
G
F
I
D
I
E
V
E
N
M
T
P
R
F
K
E
I
L
L
E
E
R
E
R
I
E
Q
D
K
E
T
F
L
A
K
F
S
Q
N
A
Y
D
G
L
-
V
S
G
W
K
S
K
L
Q
Y
--
I
A
D
D
N
H
N
W
N
F
F
A
A
V
K
P
Q
54
HHSearch
73.24
18%
-63
- C2 -
2O57
-
?
A:
[79-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
Q
R
Q
A
K
G
L
D
L
G
A
G
Y
G
G
A
A
R
F
L
V
R
K
-
F
--
G
-
V
S
I
D
---
C
L
N
I
A
P
V
Q
N
K
R
N
E
-
E
Y
N
N
Q
A
G
L
A
D
N
I
T
V
K
Y
G
S
F
L
E
I
P
C
E
D
N
S
Y
D
F
I
W
S
Q
D
A
F
L
H
S
P
--
D
K
L
K
V
F
Q
E
C
A
R
V
L
K
P
R
G
V
M
A
I
----
T
D
-----
P
-----
M
K
-
E
D
G
I
----
D
K
S
S
I
Q
P
-------
I
L
D
R
I
K
--------------
L
H
D
M
G
S
L
G
L
Y
R
S
L
A
K
E
C
G
L
V
T
L
R
T
F
S
R
P
D
S
L
V
H
H
Y
S
K
V
-
K
A
E
L
I
K
R
S
S
E
I
A
S
F
C
S
P
E
F
Q
A
N
-
M
K
R
G
L
E
H
W
I
E
G
G
R
A
G
K
L
T
W
G
G
M
L
F
R
K
---
20
PsiBlast_PDB
72.92
27%
-79
- C2 -
2GLU
4
YCGJ_BACSU
A:
[14-172]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
T
-
A
E
C
-
R
A
E
H
R
V
L
D
I
G
A
G
A
G
H
T
A
L
----
A
-
F
--
S
-
P
Y
V
Q
E
C
I
G
V
D
A
T
K
E
M
V
E
V
A
S
-
S
F
A
Q
E
K
G
V
E
N
-
V
R
F
Q
Q
G
T
A
E
S
L
P
F
P
D
D
S
F
D
I
I
T
C
R
Y
A
A
H
H
F
S
D
V
--
R
K
A
V
R
E
V
A
R
V
L
K
Q
D
G
R
F
L
L
----
V
D
-----------
H
Y
-
A
P
E
D
------
P
V
L
-
D
-------
E
F
V
N
H
L
-------
N
R
L
R
D
P
S
H
V
R
E
S
S
L
S
E
W
Q
A
M
F
S
A
N
Q
L
A
Y
Q
D
I
Q
K
W
N
L
P
I
Q
Y
D
S
W
I
K
R
G
G
T
P
A
D
R
E
K
Q
I
I
T
H
L
N
H
A
S
D
E
A
-
R
D
T
F
C
I
T
L
N
Q
--
N
G
Q
P
I
S
F
C
L
K
A
I
L
I
---
4
PsiBlast_PDB
72.54
25%
-84
- C2 -
3SXJ
1
?
A:
[30-187]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
Q
G
P
G
S
P
E
A
T
R
K
A
V
S
F
I
N
E
L
-
T
D
D
A
K
I
A
D
I
G
C
G
T
G
G
Q
T
L
F
L
A
D
Y
-
V
--
K
-
G
Q
I
T
---
G
I
D
L
F
P
D
F
I
E
I
F
N
-
E
N
A
V
K
A
N
C
A
D
R
V
K
G
I
T
G
S
M
D
N
L
P
F
Q
N
E
E
L
D
L
I
W
S
E
G
A
I
Y
---
N
I
G
F
E
R
G
M
N
E
W
S
K
Y
L
K
K
G
G
F
I
A
V
----
S
E
-----
A
-----
S
W
F
T
S
E
R
----
P
A
E
I
E
-
D
F
------
W
M
D
A
Y
P
-------
E
-----
I
S
V
I
P
T
C
I
D
K
M
E
R
A
G
Y
T
P
T
A
H
F
I
L
P
E
N
C
W
T
E
H
Y
F
A
P
Q
D
E
V
R
E
T
F
M
K
E
H
A
G
N
K
T
A
M
D
F
M
K
G
Q
Q
-
Y
E
R
S
L
Y
S
K
Y
K
--
D
Y
Y
G
Y
V
F
Y
I
G
Q
K
R
----
64
HHSearch
72.04
19%
-97
- C2 -
2YQZ
1
?
A:
[23-198]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
Q
I
A
T
A
M
A
S
A
-
V
H
P
K
G
E
E
P
V
F
L
E
L
G
V
G
T
G
R
I
A
L
P
L
I
A
R
----
G
-
Y
R
Y
I
---
A
L
D
A
D
A
A
M
L
E
V
F
R
-
Q
K
I
A
G
V
D
--
R
K
V
Q
V
V
Q
A
D
A
R
A
I
P
L
P
D
E
S
V
H
G
V
I
V
V
H
L
W
H
L
V
P
--
D
W
P
K
V
L
A
E
A
I
R
V
L
K
P
G
G
A
L
L
E
----
G
W
-----
D
-----
Q
A
-
E
A
S
P
----
E
W
T
L
Q
-
E
-------
R
W
R
A
F
A
A
E
E
G
F
P
V
E
-----
R
G
L
H
A
K
R
L
K
E
V
E
E
A
L
R
R
L
G
L
K
P
R
T
R
E
V
A
R
W
R
E
E
R
T
P
R
E
A
L
E
A
L
S
E
R
L
Y
S
F
T
Q
G
L
P
E
P
V
H
A
R
V
-
M
E
R
L
W
A
W
A
E
A
--
E
L
G
D
L
D
R
P
F
P
V
E
K
R
---
7
PsiBlast_PDB
71.30
23%
-100
- C2 -
4R6X
2
?
A:
[23-175]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
N
Y
I
S
S
G
G
L
E
A
T
K
K
I
L
S
D
-
I
E
L
-
N
E
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
M
Y
I
N
E
K
-
Y
--
G
-
A
H
T
H
---
G
I
D
I
C
S
N
I
V
N
M
A
N
-
E
R
V
S
G
N
N
K
---
I
I
F
E
A
N
D
I
L
T
K
E
F
P
E
N
N
F
D
L
I
Y
S
R
A
A
I
L
H
L
S
L
E
N
K
N
K
L
F
Q
K
C
Y
K
W
L
K
P
T
G
T
L
L
I
----
T
D
-----
Y
C
A
T
EK
E
N
-
W
D
D
E
----
F
K
E
Y
V
-
K
-------
Q
R
K
Y
T
L
-------
I
-----
T
V
E
E
Y
A
D
I
L
T
A
C
N
F
K
N
V
V
S
K
D
L
S
D
Y
W
N
Q
L
L
E
V
E
H
K
Y
L
H
E
N
K
E
E
F
L
K
L
F
S
E
K
K
F
I
S
L
D
D
G
W
S
R
-
K
I
K
D
S
K
R
K
M
Q
--
R
W
G
Y
F
K
A
T
K
N
-------
2
PsiBlast_PDB
70.44
25%
-81
- C2 -
3F4K
-
?
A:
[24-181]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
Q
G
P
G
S
P
E
A
T
R
K
A
V
S
F
I
N
E
L
-
T
D
D
A
K
I
A
D
I
G
C
G
T
G
G
Q
T
L
F
L
A
D
Y
-
V
--
K
-
G
Q
I
T
---
G
I
D
L
F
P
D
F
I
E
I
F
N
-
E
N
A
V
K
A
N
C
A
D
R
V
K
G
I
T
G
S
M
D
N
L
P
F
Q
N
E
E
L
D
L
I
W
S
E
G
A
I
Y
---
N
I
G
F
E
R
G
M
N
E
W
S
K
Y
L
K
K
G
G
F
I
A
V
----
S
E
-----
A
-----
S
W
F
T
S
E
R
----
P
A
E
I
E
-
D
F
------
W
M
D
A
Y
P
-------
E
-----
I
S
V
I
P
T
C
I
D
K
M
E
R
A
G
Y
T
P
T
A
H
F
I
L
P
E
N
C
W
T
E
H
Y
F
A
P
Q
D
E
V
R
E
T
F
M
K
E
H
A
G
N
K
T
A
M
D
F
M
K
G
Q
Q
-
Y
E
R
S
L
Y
S
K
Y
K
--
D
Y
Y
G
Y
V
F
Y
I
G
Q
K
R
----
5
PsiBlast_PDB
70.27
25%
-83
- C2 -
3T0I
1
?
A:
[30-187]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
Q
G
P
G
S
P
E
A
T
R
K
A
V
S
F
I
N
E
L
-
T
D
D
A
K
I
A
D
I
G
C
G
T
G
G
Q
T
L
F
L
A
D
Y
-
V
--
K
-
G
Q
I
T
---
G
I
D
L
F
P
D
F
I
E
I
F
N
-
E
N
A
V
K
A
N
C
A
D
R
V
K
G
I
T
G
S
M
D
N
L
P
F
Q
N
E
E
L
D
L
I
W
S
E
G
A
I
Y
---
N
I
G
F
E
R
G
M
N
E
W
S
K
Y
L
K
K
G
G
F
I
A
V
----
S
E
-----
A
-----
S
W
F
T
S
E
R
----
P
A
E
I
E
-
D
F
------
W
M
D
A
Y
P
-------
E
-----
I
S
V
I
P
T
C
I
D
K
M
E
R
A
G
Y
T
P
T
A
H
F
I
L
P
E
N
C
W
T
E
H
Y
F
A
P
Q
D
E
V
R
E
T
F
M
K
E
H
A
G
N
K
T
A
M
D
F
M
K
G
Q
Q
-
Y
E
R
S
L
Y
S
K
Y
K
--
D
Y
Y
G
Y
V
F
Y
I
G
Q
K
R
----
17
PsiBlast_PDB
70.12
23%
-97
- C2 -
3UJC
1
?
A:
[31-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
N
Y
I
S
S
G
G
L
E
A
T
K
K
I
L
S
D
-
I
E
L
-
N
E
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
M
Y
I
N
E
K
-
Y
--
G
-
A
H
T
H
---
G
I
D
I
C
S
N
I
V
N
M
A
N
-
E
R
V
S
G
N
N
K
---
I
I
F
E
A
N
D
I
L
T
K
E
F
P
E
N
N
F
D
L
I
Y
S
R
D
A
I
L
A
L
S
L
E
N
K
N
K
L
F
Q
K
C
Y
K
W
L
K
P
T
G
T
L
L
I
----
T
D
-----
Y
C
A
T
EK
E
N
-
W
D
D
E
----
F
K
E
Y
V
-
K
-------
Q
R
K
Y
T
L
-------
I
-----
T
V
E
E
Y
A
D
I
L
T
A
C
N
F
K
N
V
V
S
K
D
L
S
D
Y
W
N
Q
L
L
E
V
E
H
K
Y
L
H
E
N
K
E
E
F
L
K
L
F
S
E
K
K
F
I
S
L
D
D
G
W
S
R
-
K
I
K
D
S
K
R
K
M
Q
--
R
W
G
Y
F
K
A
T
K
N
-------
6
PsiBlast_PDB
69.85
23%
-96
- C2 -
4R6W
2
?
A:
[23-175]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
N
Y
I
S
S
G
G
L
E
A
T
K
K
I
L
S
D
-
I
E
L
-
N
E
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
M
Y
I
N
E
K
-
Y
--
G
-
A
H
T
H
---
G
I
D
I
C
S
N
I
V
N
M
A
N
-
E
R
V
S
G
N
N
K
---
I
I
F
E
A
N
D
I
L
T
K
E
F
P
E
N
N
F
D
L
I
Y
S
R
A
A
I
L
H
L
S
L
E
N
K
N
K
L
F
Q
K
C
Y
K
W
L
K
P
T
G
T
L
L
I
----
T
D
-----
Y
C
A
T
EK
E
N
-
W
D
D
E
----
F
K
E
Y
V
-
K
-------
Q
R
K
Y
T
L
-------
I
-----
T
V
E
E
Y
A
D
I
L
T
A
C
N
F
K
N
V
V
S
K
D
L
S
D
Y
W
N
Q
L
L
E
V
E
H
K
Y
L
H
E
N
K
E
E
F
L
K
L
F
S
E
K
K
F
I
S
L
D
D
G
W
S
R
-
K
I
K
D
S
K
R
K
M
Q
--
R
W
G
Y
F
K
A
T
K
N
-------
55
HHSearch
69.74
20%
-88
* C2 *
3BUS
1
REBMT_NOCAE
A:
[42-221]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
A
T
D
R
L
T
D
E
M
I
A
L
-
L
D
V
-
R
S
G
D
R
V
L
D
V
G
C
G
I
G
K
P
A
V
R
L
A
T
A
-
R
--
D
-
V
R
V
T
---
G
I
S
I
S
R
P
Q
V
N
Q
A
N
-
A
R
A
T
A
A
G
L
A
N
R
V
T
F
S
Y
A
D
A
M
D
L
P
F
E
D
A
S
F
D
A
V
W
A
L
E
S
L
H
H
M
P
--
D
R
G
R
A
L
R
E
M
A
R
V
L
R
P
G
G
T
V
A
I
----
A
D
-----
F
-----
V
L
-
L
A
P
V
----
E
G
A
K
K
-
E
-------
A
V
D
A
F
R
A
G
-----
G
-----
G
V
L
S
L
G
G
I
D
E
Y
E
S
D
V
R
Q
A
E
L
V
V
T
S
T
V
D
I
S
A
Q
A
R
P
S
L
V
K
T
A
E
A
F
E
N
A
R
S
Q
V
E
P
F
M
G
A
E
G
L
D
R
M
-
I
A
T
F
R
G
L
A
E
V
--
P
E
A
G
Y
V
L
I
G
A
R
K
P
----
71
HHSearch
69.23
21%
-96
- C2 -
3DH0
1
?
A:
[26-183]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
V
L
K
E
-
F
G
L
-
K
E
G
M
T
V
L
D
V
G
T
G
A
G
F
Y
L
P
Y
L
S
K
M
-
V
GE
K
-
G
K
V
Y
---
A
I
D
V
Q
E
E
M
V
N
Y
A
W
-
E
K
V
N
K
L
G
L
K
-
N
V
E
V
L
K
S
E
E
N
K
I
P
L
P
D
N
T
V
D
F
I
F
M
A
F
T
F
H
E
L
S
--
E
P
L
K
F
L
E
E
L
K
R
V
A
K
P
F
A
Y
L
A
I
----
I
D
-----
W
-----
K
K
-
E
E
R
D
----
K
G
-------------------------
P
-----
P
P
E
E
V
Y
S
E
W
E
V
G
L
I
L
E
D
A
G
I
R
V
G
R
V
V
E
V
G
K
Y
C
F
G
V
Y
A
M
I
V
----------------------------------------------------
18
PsiBlast_PDB
69.23
23%
-98
- C2 -
3UJD
1
?
A:
[31-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
N
Y
I
S
S
G
G
L
E
A
T
K
K
I
L
S
D
-
I
E
L
-
N
E
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
M
Y
I
N
E
K
-
Y
--
G
-
A
H
T
H
---
G
I
D
I
C
S
N
I
V
N
M
A
N
-
E
R
V
S
G
N
N
K
---
I
I
F
E
A
N
D
I
L
T
K
E
F
P
E
N
N
F
D
L
I
Y
S
R
D
A
I
L
H
L
S
L
E
N
K
N
K
L
F
Q
K
C
Y
K
W
L
K
P
T
G
T
L
L
I
----
T
D
-----
Y
C
A
T
EK
E
N
-
W
D
D
E
----
F
K
E
Y
V
-
K
-------
Q
R
K
Y
T
L
-------
I
-----
T
V
E
E
Y
A
D
I
L
T
A
C
N
F
K
N
V
V
S
K
D
L
S
D
Y
W
N
Q
L
L
E
V
E
H
K
Y
L
H
E
N
K
E
E
F
L
K
L
F
S
E
K
K
F
I
S
L
D
D
G
W
S
R
-
K
I
K
D
S
K
R
K
M
Q
--
R
W
G
Y
F
K
A
T
K
N
-------
9
PsiBlast_PDB
69.21
25%
-83
- C2 -
4IV0
2
?
A:
[43-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
E
F
I
--
F
G
E
D
Y
I
S
S
G
G
I
I
A
T
T
K
I
L
S
D
-
I
Q
L
-
D
A
N
S
K
V
L
D
I
G
S
G
L
G
G
G
C
K
Y
I
N
E
K
-
Y
--
G
-
A
H
V
H
---
G
V
D
I
C
E
K
M
V
T
I
A
K
L
R
N
Q
D
K
A
K
----
I
E
F
E
A
K
D
I
L
K
K
D
F
P
E
S
T
F
D
M
I
Y
S
R
D
S
I
L
H
L
S
Y
A
D
K
K
M
L
F
E
K
C
Y
K
W
L
K
P
N
G
I
L
L
I
----
T
D
Y
C
A
D
K
I
-----
E
N
-
W
D
E
E
----
F
K
A
Y
I
-
K
-------
K
R
K
Y
T
L
-------
M
-----
P
I
Q
E
Y
G
D
L
I
K
S
C
K
F
Q
N
V
E
A
K
D
I
S
D
Y
W
L
E
L
L
Q
L
E
L
S
K
L
E
E
K
K
E
E
F
L
K
V
Y
S
I
K
E
Y
N
S
L
K
D
G
W
T
R
-
K
I
K
D
T
K
R
D
L
Q
--
K
W
G
Y
F
K
A
Q
K
M
I
------