@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0497: (2015-12-01 )
MKKSFIHQQQEISFVKNTFTQYLIDKLEIVEVQGPILSQVGDGMQDNLSGIEHPVSVKVLNIPEAEFEVVHSLAKWKRHTLARFGFNEGEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPDGRRNLDYLKETVEKIYKAIRLTELAVEARFDIESILPKRITFIHTEELVEKYPDLSPKERENAIAKEYGAVFLIGIGGELADGKPHDGRAPDYDDWTTPSENGFKGLNGDILVWNEQLGTAFELSSMGIRVDEDALKRQVVLTGDEGRLEFEWHKTLLRGFFPLTIGGGIGQSRLAMFLLRKKHIGEVQSSVWPKEVRDTFENIL
Atome Classification :
(20 SA)
----.........10........20..-......30.....---------------...40....-....50-.-.-----.....----.60..----....-------..70----........80....---.....90........100...--....110.......120..-.-...----.130..------.....140....-.-.------.---150.---.-------..---.---..160..------------------...----...170----.......180-------.--------------.---------------.-------------------------------------------------------------------------------.-------.-----------------------.---.-----.-----.-------190-----------.-.----.------......200-----....------------..---.210.......220--------......-...--230.......240.....-..250.-....---..260......---.---270........280....-...290......----.300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
K
K
S
F
I
H
Q
Q
Q
E
I
S
F
V
K
N
T
F
T
Q
Y
L
-
I
D
K
L
E
I
V
E
VQ
G
P
I
---------------
L
S
Q
VGDG
M
Q
-
D
NLSGI-E-H-----P
V
S
V
K
----
V
L
NIP----
E
A
E
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
H
T
-
L
A
RF---GFNEG
E
G
L
F
V
H
M
KALRPDEDS--LDPT
H
S
V
Y
VDQW
D
W
E
KVIP-D-GRR----
N
L
D
Y
L
K
------
E
T
V
E
K
I
Y
K
A
I
R
L
-
T
-
E
------
L
---
A
V
E
A
---R-------F
D
---
I
---
E
S
I-
L
P
K
------------------
R
I
T
----
F
I
H
T
E
E
----
L
V
E
KYPDL---------
S
--------------
P
---------------
K
-------------------------------------------------------------------------------
E
-------
R
-----------------------
E
---
N
-----
A
-----
I
-------
A
-------------
K
-E----Y------G
A
V
F
L
I
GIG-----GELA------------DG---KPHDGRAPDYDD----------WTTPSE-NGF--KGLNG
D
I
L
V
W
NEQLG
T
A
F
-
E
L
SSMG-
I
R
V
D
---
E
D
A
LK
R
Q
V
V
L
T---G---DE-
G
R
L
E
F
E
W
H
K
T
L
L
RGF-F
P
L
T
IGGGI
G
Q
S
----
R
L
A
M
F
L
L
R
K
K
H
I
G
E
V
Q
SSV
W
P
K
E
V
R
D
T
F
E
NIL
46
Fugue
97.55
62%
-67
- C4 -
12AS
2
ASNA_ECOLI
A:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
---
D
F
S
A
G
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-----
G
K
L
S
------------
D
G
---
H
R
H
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
2
PsiBlast_PDB
97.55
62%
-67
- C4 -
12AS
2
ASNA_ECOLI
A:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
---
D
F
S
A
G
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-----
G
K
L
S
------------
D
G
---
H
R
H
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
18
PsiBlast_CBE
96.66
62%
-64
- C4 -
12AS
2
ASNA_ECOLI
B:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
---
D
F
S
A
G
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-----
G
K
L
S
------------
D
G
---
H
R
H
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
1
PsiBlast_PDB
96.52
62%
-62
- C4 -
11AS
1
ASNA_ECOLI
A:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
---
D
F
S
A
G
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-----
G
K
L
S
------------
D
G
---
H
R
H
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
19
PsiBlast_CBE
96.35
62%
-63
- C4 -
11AS
1
ASNA_ECOLI
B:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
---
D
F
S
A
G
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-----
G
K
L
S
------------
D
G
---
H
R
H
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
25
HHSearch
95.56
62%
-64
- C4 -
12AS
2
ASNA_ECOLI
A:
[4-330]
-------
A
Y
I
A
K
Q
R
Q
I
S
F
V
K
S
H
F
S
R
Q
L
-
E
E
R
L
G
L
I
E
V
Q
A
P
I
---------------
L
S
R
V
G
D
G
T
Q
-
D
N
L
S
G
A
-
E
-
K
-----
A
V
Q
V
K
----
V
K
A
L
P
----
D
A
Q
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
Q
T
-
L
G
Q
H
DFS
A
G
---
E
G
L
Y
T
H
M
K
A
L
R
P
D
E
D
R
--
L
S
P
L
H
S
V
Y
V
D
Q
W
D
W
E
R
V
M
G
-
D
-
G
E
R
----
Q
F
S
T
L
K
------
S
T
V
E
A
I
W
A
G
I
K
A
-
T
-
E
------
A
---
A
V
S
E
---
E
-------
F
G
---
L
---
A
P
F
-
L
P
D
------------------
Q
I
H
----
F
V
H
S
Q
E
----
L
L
S
R
Y
P
D
L
---------
D
--------------
A
---------------
K
-------------------------------------------------------------------------------
G
-------
R
-----------------------
E
---
R
-----
A
-----
I
-------
A
-------------
K
-
D
----
L
------
G
A
V
F
L
V
G
I
G
-------
G
K
------------
L
S
DGH
R
H
-
D
V
R
A
P
D
Y
D
D
----------
W
S
T
P
S
E
-
L
G
H
--
A
G
L
N
G
D
I
L
V
W
N
P
V
L
E
D
A
F
-
E
L
S
S
M
G
-
I
R
V
D
---
A
D
T
L
K
H
Q
L
A
L
T
---
G
---
D
E
-
D
R
L
E
L
E
W
H
Q
A
L
L
R
G
E
-
M
P
Q
T
I
G
G
G
I
G
Q
S
----
R
L
T
M
L
L
L
Q
L
P
H
I
G
Q
V
Q
A
G
V
W
P
A
A
V
R
E
S
V
P
S
L
L
3
PsiBlast_PDB
95.47
56%
-86
- C4 -
4LNS
-
?
A:
[8-345]
-------
S
Y
V
L
L
Q
E
Q
I
L
T
V
K
R
S
F
S
E
A
L
-
E
K
E
L
N
L
V
E
V
R
A
P
I
---------------
L
F
R
V
G
D
G
T
Q
-
D
--------------
A
V
Q
V
P
----
V
K
A
I
P
----
N
A
S
F
-------
E
V
V
H
----
S
L
A
K
W
K
R
R
T
-
L
A
N
Y
---
K
F
A
P
G
H
G
L
Y
T
H
M
T
A
L
R
V
D
-
D
V
--
L
D
N
I
H
S
V
V
V
D
Q
W
D
W
E
M
V
M
K
-
D
-
D
Q
R
----
N
L
A
F
L
K
------
E
V
V
C
K
V
Y
A
A
I
R
K
-
T
-
E
------
L
---
A
V
C
E
---
K
-------
Y
K
---
Q
---
K
P
I
-
L
P
E
------------------
T
I
Q
----
F
V
H
A
E
H
----
L
L
L
A
Y
P
N
L
---------
T
--------------
A
---------------
K
-------------------------------------------------------------------------------
E
-------
R
-----------------------
E
---
R
-----
E
-----
I
-------
A
-------------
R
-
E
----
Y
------
G
A
V
F
L
I
G
I
G
-----
A
V
L
S
------------
S
--------------------------------L
S
S
L
--
K
G
L
N
G
D
I
L
L
Y
N
P
T
L
D
D
S
L
-
E
V
S
S
M
G
-
I
R
V
N
---
A
E
A
L
R
H
Q
I
S
L
T
---
G
---
D
D
-
S
L
L
K
S
E
W
H
Q
Q
L
L
N
G
E
-
F
P
Q
T
V
G
G
G
I
G
Q
S
----
R
M
V
M
F
M
L
R
K
K
H
I
G
E
V
Q
C
S
V
W
P
E
E
I
R
K
K
H
N
L
--
32
HHSearch
57.27
17%
-43
- C4 -
1EOV
-
SYDC_YEAST
A:
[247-553]
-------
I
F
R
I
Q
A
G
V
C
E
L
F
R
E
Y
L
A
------
T
K
K
F
T
E
V
H
T
P
K
---------------
L
L
G
A
P
S
E
G
G
-
S
S
V
F
E
V
-------------
T
----
Y
F
K
-------
G
K
A
-------
Y
L
A
Q
----
S
P
Q
F
N
K
Q
Q
L
-
I
V
A
----
D
F
---
E
R
V
Y
E
I
G
P
V
F
R
A
-
E
N
S
--
N
T
H
R
H
M
T
E
F
T
G
L
D
M
E
M
A
F
E
-
E
H
Y
H
E
----
V
L
D
T
L
S
------
E
L
F
V
F
I
F
S
E
L
P
K
R
F
-
A
------
H
---
E
I
E
L
---
V
R
K
Q
----
Y
P
---
V
EEF
K
L
P
-
K
D
G
------------------
K
M
V
----
R
L
T
Y
K
E
----
G
I
E
M
L
R
A
A
---------
G
K
E
I
G
DFEDL-----
S
---------------
T
-------------------------------------------------------------------------------
E
-------
N
-----------------------
E
---
K
-----
F
-----
L
-------
G
-------------
K
-
L
V
R
D
K
Y
DT----
D
F
Y
I
L
D
K
F
P
-------
L
E
------------
I
R
---
P
F
Y
T
M
P
D
P
A
N
P
K
----------
Y
S
------------
N
S
Y
D
F
F
M
R
G
E
E
I
L
S
G
A
Q
R
I
H
D
H
A
-
L
L
-----
Q
E
R
M
K
A
H
G
--
L
---
S
---
P
E
-
D
P
G
L
K
D
Y
C
D
G
F
-
S
Y
G
-
C
P
P
H
A
G
G
G
I
G
L
E
----
R
V
V
M
F
Y
L
D
L
K
N
I
R
R
A
S
--
L
F
P
R
D
P
K
R
L
R
P
---
29
HHSearch
54.67
15%
-45
- C4 -
3M4P
4
?
A:
[154-451]
------
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
------
D
N
H
F
T
E
I
Q
P
P
T
---------------
I
V
K
-------
S
T
L
F
K
L
-------------
Q
----
Y
F
N
-------
E
P
A
-------
Y
L
T
Q
----
S
S
Q
L
Y
L
E
S
V
-
I
A
-----
S
L
---
G
K
S
F
C
M
L
S
S
Y
R
A
-
E
Q
S
--
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
E
D
----
L
L
N
H
L
E
------
D
L
V
C
T
V
I
D
N
V
M
A
-
V
-
H
G
-----
D
---
K
I
R
K
---
M
-------
N
P
---
H
---
L
K
L
-
P
T
R
------------------
P
F
K
----
R
M
T
Y
A
D
----
A
I
K
Y
C
N
D
H
---------
G
ILNKD
K
P
F
E
YG
E
D
I
S
---------------
E
-------------------------------------------------------------------------------
K
-------
P
-----------------------
E
---
R
-----
Q
-----
M
-------
T
-------------
D
-
E
----
I
G-----
C
P
I
F
M
I
H
F
P
-------
S
K
------------
M
K
---
A
F
Y
M
S
K
V
P
G
H
P
D
----------
L
T
------------
E
S
V
D
L
L
M
------
P
G
V
G
E
I
V
G
G
S
-
M
R
-----
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
---
L
N
-
P
D
P
Y
Y
W
Y
T
Q
Q
R
-
K
Y
G
-
S
C
P
H
G
G
Y
G
L
G
V
E
----
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
--
L
Y
P
R
Y
L
E
R
C
E
P
---
33
HHSearch
54.62
17%
-57
- C4 -
3I7F
-
?
A:
[239-539]
-------
I
F
R
I
Q
S
A
C
C
G
L
F
R
E
F
L
T
------
S
Q
K
F
V
E
I
H
T
P
K
---------------
L
I
--------------------------------------------
A
-------
Y
L
A
Q
----
S
P
Q
L
Y
K
Q
M
A
-
I
M
G
----
D
F
---
R
K
V
F
E
V
G
P
V
F
R
A
-
E
N
S
--
N
T
R
R
H
L
T
E
F
E
G
L
D
I
E
M
E
I
V
E
N
-
Y
H
E
----
C
I
D
V
M
E
------
K
L
F
T
F
I
F
D
E
I
P
K
-
R
F
P
------
D
---
E
L
K
V
I
R
K
Q
-------
Y
P
---
F
---
E
D
L
-
I
Y
R
------------------
P
F
L
----
R
L
T
Y
K
E
----
A
I
E
M
L
R
A
S
---------
G
E
T
I
G
DY
D
D
F
-----
T
---------------
T
-------------------------------------------------------------------------------
P
-------
Q
-----------------------
E
---
V
-----
K
-----
L
-------
G
-------------
E
-
L
I
K
A
K
Y
NT----
D
F
Y
I
L
D
K
F
P
-------
A
A
------------
I
R
---
P
F
Y
T
M
P
D
I
D
D
P
N
----------
Y
S
------------
N
S
Y
D
V
F
V
R
------
G
Q
-
E
I
T
S
G
A
-
Q
R
-----
I
H
D
P
E
F
L
M
K
R
C
I
E
K
G
---
V
D
-
P
A
T
L
K
D
Y
I
E
S
F
-
R
F
G
-
S
W
P
H
A
G
C
G
I
G
L
E
----
R
I
T
M
L
Y
L
G
I
P
N
I
R
K
V
T
--
L
F
P
R
D
P
I
R
L
N
P
---
37
HHSearch
54.58
22%
-42
- C4 -
1NNH
-
?
A:
[14-287]
-------
T
L
D
I
Q
T
K
I
L
E
Y
M
T
D
F
F
V
------
K
E
G
F
K
W
L
L
P
V
I
---------------
I
S
P
I
T
D
P
L
W
-
P
D
P
A
G
E
G
M
-
E
-----
P
A
E
V
E
----
I
Y
G
-------
V
K
M
-------
R
L
T
H
----
S
M
I
L
H
K
Q
L
A
-
I
A
M
----
G
L
---
K
K
I
F
V
L
S
P
N
I
R
L
-
E
S
R
QK
D
D
G
R
H
A
Y
E
F
T
Q
L
D
F
E
V
E
R
A
-
K
-
M
E
D
----
I
M
R
L
I
E
------
R
L
V
Y
G
L
F
R
K
A
E
E
-
W
-
T
-----------
G
R
---------------------
E
F
P
-
K
T
K
------------------
R
F
E
----
V
F
E
Y
S
E
----
V
L
E
E
F
G
S
D
---------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
A
-------
S
-------------
Q
E
M
----
E
------
E
P
F
W
I
I
N
I
P
-------
R
------------------
E
F
Y
D
R
E
V
---
D
G
----------
F
W
------------
R
N
Y
D
L
I
-----
L
P
Y
G
Y
G
E
V
A
S
G
G
-
E
R
-----
E
W
E
Y
E
K
I
V
A
K
I
R
K
A
G
---
L
N
-
E
D
S
F
R
P
Y
L
E
I
A
-
K
A
G
K
L
K
P
S
A
G
A
G
I
G
V
E
----
R
L
V
R
F
I
V
G
A
K
H
I
A
E
V
Q
P
--
F
P
R
I
P
G
I
P
A
V
I
--
38
HHSearch
54.41
13%
-31
- C4 -
3A5Y
1
EPMA_ECOLI
A:
[35-344]
-------
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
------
D
R
G
V
L
E
V
E
T
P
C
---------------
M
S
Q
A
T
V
T
D
I
H
L
V
P
F
E
T
-
R
-
F
VGPGH
S
Q
G
M
N
----
L
W
-
L
M
----
T
------------------
S
P
E
Y
H
M
K
R
L
-
L
V
A
----
G
C
---
G
P
V
F
Q
L
C
R
S
F
R
N
-
E
-
E
--
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
-
D
-
M
Y
R
----
L
M
N
E
V
D
------
D
L
L
Q
Q
V
L
D
C
P
A
A
-
E
-
S
------
L
---
S
Y
Q
Q
---
A
-------
F
L
---
R
---
Y
L
E
I
D
P
L
------------------
S
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
Q
L
L
F
T
F
G
-----
V
-------
E
-------------
P
-
N
----
I
GKE---
K
P
T
F
V
Y
H
F
P
-------
A
S
------------
Q
A
---
S
L
A
Q
I
S
-
T
E
D
H
R
----------
V
A
------------
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
-
E
Q
-----
Q
Q
R
F
E
Q
D
N
R
K
R
---
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
-
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
----
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
--
A
F
S
V
D
R
A
-------
36
HHSearch
53.56
15%
-36
- C4 -
1L0W
-
SYD_THETH
A:
[143-556]
-------
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
------
R
E
G
F
V
Q
V
E
T
P
F
---------------
L
T
K
S
T
P
E
G
A
-
R
-
D
F
L
V
-------------
P
----
Y
R
H
E
P
----
G
L
F
Y
-------
A
L
P
Q
----
S
P
Q
L
F
K
Q
M
L
-
M
V
A
----
G
L
---
D
R
Y
F
Q
I
A
R
C
F
R
D
-
E
-
D
--
L
R
A
D
R
Q
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
-
V
E
D
----
V
L
E
L
N
E
------
R
L
M
A
H
V
F
R
E
A
L
G
-
V
-
E
--------------------------------------
L
P
L
------------------
P
F
P
----
R
L
S
Y
E
E
----
A
M
E
R
Y
G
S
D
---------
K
--------------
P
---------------
D
LRFGL
E
L
K
E
VGPLFRQSGFRVFQEAE
S
V
K
A
L
A
L
PKALS
R
K
E
V
A
E
L
E
E
V
A
K
R
H
KAQ
G
L
A
W
A
R
V
E
EGGFSGGVAKFLEPV
R
E
-------
A
L
L
Q
A
T
EARPG
D
T
L
L
F
V
A
G
P
R
K
V
A
A
---
T
-----
A
-----
L
-------
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
----
F
------
R
F
L
W
V
V
D
F
P
-------
L
L
EWDEEE
E
A
W
T
Y
M
H
H
---
P
F
-
T
S
P
H
P
E
D
L
P
----------
L
L
E
K
D
P
-
G
R
V
--
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
-
L
Q
-----
A
R
V
F
R
L
L
G
I
G
E
---
E
---
E
Q
-
R
E
K
F
G
F
F
L
E
A
L
-
E
Y
G
-
A
P
P
H
G
G
I
A
W
G
L
D
----
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
--
F
P
K
N
K
E
G
K
D
P
L
T
G
27
HHSearch
52.65
15%
-39
- C4 -
1E1O
9
SYK2_ECOLI
A:
[181-500]
------
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
------
A
R
G
F
M
E
V
E
T
P
M
---------------
M
Q
V
I
P
G
G
A
S
-
A
R
P
F
I
T
-
H
----------
H
N
----
A
L
D
-------
L
D
M
-------
Y
L
R
I
----
A
P
E
L
Y
L
K
R
L
-
V
V
G
----
G
F
---
E
R
V
F
E
I
N
R
N
F
R
N
-
E
-
G
--
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
-
D
-
Y
H
D
----
L
I
E
L
T
E
------
S
L
F
R
T
L
A
Q
E
V
L
G
-
T
-
T
----------
K
V
T
Y
---
G
--------
E
---
H
---
V
F
D
-
F
G
K
------------------
P
F
E
----
K
L
T
M
R
E
----
A
I
K
K
Y
R
P
E
---------
T
D
M
A
D
L
D
--------
N
F
--------------
D
A
A
K
A
L
A
E
S
I
GITV------------------------------------------------------------------
E
KSWG
L
G
R
I
-----------------------
V
---
T
-----
E
I
F
D
E
V
A
-------
E
-------------
A
-
H
L---
I
------
Q
P
T
F
I
T
E
Y
P
-------
A
E
------------
V
S
---
P
L
A
R
R
-
N
D
V
N
P
E
----------
I
T
------------
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
-
D
Q
-----
A
E
R
F
Q
E
Q
V
N
A
K
A
A
-
G
DD-
E
A
-
M
F
Y
D
E
D
Y
V
T
A
L
-
E
Y
G
-
L
P
P
T
A
G
L
G
I
G
I
D
----
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
--
F
P
A
M
R
P
-------
34
HHSearch
52.30
19%
-42
- C4 -
3NEM
1
SYD_THEKO
A:
[136-434]
-------
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
------
E
N
G
F
I
E
I
H
T
P
K
---------------
I
I
A
T
A
T
E
G
G
-
T
E
L
F
P
-------------
M
K
----
Y
F
E
-------
E
D
A
-------
F
L
A
Q
----
S
P
Q
L
Y
K
Q
I
M
-
M
A
S
----
G
L
---
D
R
V
Y
E
I
A
P
I
F
R
A
-
E
E
H
--
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
-
E
E
E
----
V
M
S
F
L
E
------
R
L
V
A
H
A
I
N
Y
V
R
E
-
H
N
A
------
K
---
E
L
D
I
---
L
-------
N
F
---
E
---
L
E
E
-
P
K
L
------------------
P
F
P
----
R
V
S
Y
D
K
----
A
L
E
I
L
G
D
L
---------
G
K
E
I
P
WGEDI-----
D
---------------
T
-------------------------------------------------------------------------------
E
-------
G
-----------------------
E
---
R
-----
L
-----
L
-------
G
-------------
K
-
Y
----
M
M
E
NENA
P
L
Y
F
L
Y
Q
Y
P
-------
S
E
------------
A
K
---
P
F
Y
I
M
K
Y
D
N
K
P
E
----------
I
C
------------
R
A
F
D
L
E
Y
R
G
------
V
-
E
I
S
S
G
G
-
Q
R
E
H
R--
H
D
I
L
V
E
Q
I
K
E
K
---
G
---
L
N
-
P
E
S
F
E
F
Y
L
K
A
F
-
R
Y
G
-
M
P
P
H
G
G
F
G
L
G
A
E
----
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
--
F
P
R
D
R
R
R
L
T
P
---
26
HHSearch
52.30
16%
-36
- C4 -
1WYD
3
SYDND_SULTO
A:
[133-426]
-------
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
------
K
E
G
F
I
E
I
F
T
P
K
---------------
I
I
A
S
A
T
E
G
G
-
A
Q
L
F
P
-------------
V
I
----
Y
F
G
-------
K
E
A
-------
F
L
A
Q
----
S
P
Q
L
Y
K
E
L
M
-
A
G
-----
V
V
---
E
R
V
F
E
V
A
P
A
W
R
A
-
E
E
S
--
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
A
-
D
-
Y
N
D
----
V
M
Q
L
L
E
------
K
I
L
H
N
I
V
K
T
I
K
E
-
E
-
G
K
-----
E
---
E
L
K
I
---
L
-------
N
Y
---
E
---
P
P
E
-
V
K
I
------------------
P
I
K
----
R
L
K
Y
T
E
----
A
I
E
I
L
R
S
K
GYNIKFG
D
D
I
--------------
G
---------------
T
-------------------------------------------------------------------------------
P
-------
E
-----------------------
L
---
R
-----
I
-----
L
-------
N
-------------
E
-
E
----
L
KE----
D
L
Y
F
I
V
D
W
P
-------
S
D
------------
A
R
---
P
F
Y
T
K
S
K
S
E
-
P
E
----------
L
S
------------
E
S
F
D
L
I
Y
K
------
F
L
-
E
I
V
S
G
S
-
T
R
N
H
K--
R
E
V
L
E
E
A
L
K
K
K
---
G
---
L
K
-
P
E
S
F
E
F
F
L
K
W
F
-
D
Y
G
-
M
P
P
H
A
G
F
G
M
G
L
A
----
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
--
P
F
P
R
D
K
K
R
L
T
P
---
35
HHSearch
51.07
13%
-40
- C4 -
2XGT
2
?
A:
[130-430]
------
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
------
N
A
G
Y
V
E
V
A
P
P
T
---------------
L
V
Q
T
Q
V
E
G
G
-
S
T
L
F
N
-------------
L
D
----
Y
F
G
-------
E
Q
S
-------
F
L
T
Q
----
S
S
Q
L
Y
L
E
T
C
-
I
P
-----
T
L
---
G
D
V
F
C
I
A
Q
S
Y
R
A
-
E
K
S
--
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
I
-
T
-
L
D
D
----
L
M
E
K
I
E
------
E
L
V
C
D
T
V
D
R
L
L
A
-
D
-
E
------
E
A
K
K
L
L
E
H
---
I
-------
N
P
---
K
---
F
Q
P
-
P
E
R
------------------
P
F
L
----
R
M
E
Y
K
D
----
A
I
K
W
L
Q
E
H
---------
N
--------------
V
ENEFGNTFTYGEDIA
E
-------------------------------------------------------------------------------
A
-------
A
-----------------------
E
---
R
-----
F
-----
M
-------
T
-------------
D
-
T
----
I
N-----
K
P
I
L
L
N
R
F
P
-------
S
E
------------
I
K
---
A
F
Y
M
Q
R
D
A
Q
D
N
T
----------
L
T
------------
E
S
V
D
L
L
M
P
------
G
V
G
E
I
V
G
G
S
-
M
R
-----
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
---
I
D
-
P
K
P
Y
Y
W
Y
L
D
Q
R
-
L
Y
G
-
T
C
P
H
G
G
Y
G
L
G
L
E
----
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
--
L
Y
P
R
F
V
G
R
C
V
P
---
28
HHSearch
49.96
17%
-32
- C4 -
3A74
5
SYK_GEOSE
A:
[172-491]
------
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
------
S
H
G
Y
L
E
V
E
T
P
M
---------------
M
H
A
V
A
G
G
A
A
-
A
R
P
F
I
T
-
H
H
N
-----
A
L
D
M
T
----
L
Y
-
M
R
------------------
I
----
A
I
E
L
H
L
K
R
L
I
V
G
-----
G
L
---
E
K
V
Y
E
I
G
R
V
F
R
N
-
E
-
G
--
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
-
D
-
F
R
D
----
I
M
K
L
T
E
------
N
L
I
A
H
I
A
T
E
V
L
G
-
T
-
T
------
K
----
I
Q
Y
---
G
-------
E
H
-------
L
V
D
-
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
VGVD
F
W
R
----
Q
M
S
D
E
E
----
A
R
E
L
A
K
E
H
---------
G
--------------
V
E
V
A
PHMT
F
-------
G
-------------------------------------------------------------------------------
H
I
V
N
E
F
--
F
-----------------------
E
---
Q
-----
K
-----
V
-------
E
-------------
D
-
K
----
L
I-----
Q
P
T
F
I
Y
G
H
P
-------
V
E
------------
I
S
---
P
L
A
-
K
K
N
P
D
D
P
R
----------
F
T
------------
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
-
D
Q
-----
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
-
G
ND-
E
A
-
H
E
M
D
E
D
F
L
E
A
L
-
E
Y
G
-
M
P
P
T
G
G
L
G
I
G
V
D
----
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
--
L
F
P
Q
M
R
H
-------
30
HHSearch
49.78
16%
-37
* C4 *
1X54
3
SYN_PYRHO
A:
[134-430]
-------
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
------
K
D
G
W
H
E
V
F
P
P
I
---------------
L
V
T
G
A
V
E
G
G
-
A
T
L
F
K
L
-------------
K
----
Y
F
D
-------
K
Y
A
-------
Y
L
S
Q
----
S
A
Q
L
Y
L
E
A
A
-
I
F
-----
G
L
---
E
K
V
W
S
L
T
P
S
F
R
A
-
E
K
S
--
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
M
-
D
-
L
W
D
----
I
M
K
V
E
E
------
E
L
V
S
Y
M
V
Q
R
T
L
E
-
L
-
R
K
-----
K
---
E
I
E
M
---
F
-------
R
D
DL
T
T
---
L
K
N
-
T
E
P
------------------
P
F
P
----
R
I
S
Y
D
E
----
A
I
D
I
L
Q
S
K
---------
G
VNVEWGDDL-----
G
---------------
A
-------------------------------------------------------------------------------
D
-------
E
-----------------------
E
---
R
-----
V
-----
L
-------
T
-------------
E
-
E
----
F
D-----
R
P
F
F
V
Y
G
Y
P
-------
K
H
------------
I
K
---
A
F
Y
M
K
E
D
P
N
D
P
R
----------
K
V
------------
L
A
S
D
M
L
-----
A
P
E
G
Y
G
E
I
I
G
G
S
-
Q
R
-----
E
D
D
Y
D
K
L
L
N
R
I
---
L
E
E
G
M
D
-
P
K
D
Y
E
W
Y
L
D
L
R
-
R
Y
G
-
S
V
P
H
S
G
F
G
L
G
V
E
----
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
--
L
F
P
R
T
P
A
R
L
Y
P
---
47
Fugue
44.79
23%
-42
* C7 *
4C2E
-
CTPB_BACSU
A:
[2-436]
AD
S
E
R
D
K
A
M
D
K
I
E
K
A
Y
E
L
I
S
N
E
Y
V
E
K
V
D
R
E
K
L
L
E
G
A
I
Q
G
M
L
S
T
L
NDPYS
V
Y
M
D
K
Q
T
A
K
Q
F
S
D
S
L
D
-
S
S
F
E
G
I
-
G
-
A
-----
E
V
G
M
E
DG
K
I
I
I
V
S
P
FKKS
P
A
E
K
A
GLKPND
E
I
I
S
INGE
S
M
A
G
-
K
D
L
N
-
H
A
V
L
---
K
I
R
G
K
K
G
S
S
V
S
M
K
I
Q
R
P
G
T
K
K
---
Q
L
S
F
R
I
K
R
A
E
I
P
L
E
T
V
F
A
-
S
-
E
K
K
V
QG
H
S
V
G
Y
I
A
I
STFSE
H
T
T
E
D
F
A
K
A
L
R
E
-
L
-
E
K
K
EIE
G
L
---
V
I
D
V
---
R
GNPGGY
I
Q
S
---
V
---
E
E
I
-
L
K
H
------------------
F
V
T
KDQP
Y
I
Q
I
A
E
RNG
D
K
K
R
Y
F
S
T
L
---------
T
--------------
H
---------------
K
-------------------------------------------------------------------------------
K
-------
A
-----------------------
Y
P
V
-
N
-----
V
-----
I
T
D
KGSA
A
A
-------------
S
-
E
----
I
------
L
A
G
A
L
K
E
A
G
H
Y
D
V
V
G
D
T
S
------------
F
G
---
K
G
T
V
Q
Q
A
V
P
M
G
D
G
S
N
I
K
L
T
L
Y
K
W
L
T
P
N
G
-
N
W
I
HK
K
G
I
E
P
T
I
A
I
K
Q
P
D
Y
F
S
A
G
-
P
L
Q
L
K
E
P
L
K
V
D
MNN
E
D
V
K
H
A
Q
V
L
L
K
---
G
L
SF
D
P
-
G
R
E
D
G
Y
F
S
K
D
M
K
K
A
V
-
M
A
F
Q
D
Q
N
K
L
N
K
T
GIID
T
R
T
A
E
T
L
N
Q
Q
I
E
K
K
K
S
D
E
K
N
D
L
Q
L
Q
T
A
L
K
S
L
F