@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0502: (2015-12-01 )
MKNKDPKRKHKSLLGLLKWWIIGFAFLLLVLASLVVRLPYYLEMPGGAYDIRSVLKVNKKADKAKGSYNFVAVSVSQATPAQVLYAWLTPFTELSSKEETTGGFSNDDYLRINQFYMETSQNESVYQALKLANKQVSLTYKGVYVLNLAKNSTFKDRLHLADTVTGVNGKSFKNSSQLIKYVAALHLGDKVKVQYTSQGKKKESVGKVIKLSNGKNGIGIGLTDHTEVSSDVPVDFNTEGVGGPSAGLMFTLAIYDQLVKEDLRKGRKIAGTGTIEQNGHVGDIGGAGLKVVSAAKKGMDIFFVPNNPIDKNAKKGKTKVQTNYQEAKAAAKRLGTKMKIVPVQNVQQAIDYLKKTK
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------.........10........20........30.....-...40........50......--..60----.........70.........80-------------........90----...-----------....-----..100-........110-----........120.--------------......130.....-----..140.......150....------.-..160...---------------------------....170-.---------......180.......--190......--.200.......210---.---...-....220.---......-----230....--..--.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340-.......350-.....--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------MKNK
D
P
K
R
K
H
K
S
L
L
G
L
L
K
W
W
I
I
G
F
A
F
L
L
L
V
L
A
S
L
V
V
-RL
P
Y
Y
LEMPG
G
A
Y
D
I
R
S
V
L
K
V--NKK-----ADKAKGSY
N
F
-
V
A
V
SVSQA
T
P
A
-------------
Q
V
L
Y
A
W
LT
P
-----
F
T
E
-----------LSSK-----EETT--GGFSND
D
Y
L
R
------
I
N
Q
F
Y
METSQ
N
E
--------------
S
V
Y
Q
A
L
K
LAN
K
Q
V
S
-----
L
T
Y
K
G
V
Y
V
L
N
LAKNS
T
F
K
D
------
R
-
L
H
L
A
D
T
VT---------------------------GVNGKSF-K---------
N
S
S
Q
L
I
K
Y
V
A
A
LHLG
D
--
K
V
K
V
Q
YTSQ--GK
K
K
E
SVG
K
V
I
K
-L---S---NGK-N
G
I
G
I
GLT---DHTEVS-----SDVPVDF--NT--EGVGGPSAG
L
M
F
T
L
A
I
Y
D
Q
L
V
K
E
D
L
RKG
R
K
IAGTGTIEQNGHVGDIGG
A
G
L
K
V
V
S
A
A
KK
G
M
D
I
F
F
VPNNPIDKNAKKGK
T
K
V
Q
T
N
Y
Q
E
A
K
A
A
A
K
RLGT
K
M
K
I
V
P
-
V
Q
N
V
Q
Q
A
I
D
Y
-
L
KKTK--------------------------------
52
Fugue
73.55
17%
-33
* C2 *
4K70
22
?
A:
[2-483]
---------------------------------------------------PG
S
M
E
A
L
V
R
A
L
E
EADHAV
A
T
V
V
Q
S
R
I
L
E
F
F
M
AA
G
R
E
T
P
A
G
V
R
G
L
W
A
R
A
L
R
L
A
C
R
A
Y
V
E
T
G
T
C
E
A
A
V
L
A
E
N
L
A
G
L
A
L
W
R
L
R
H
D
W
D
E
--
G
T
A
P
L
L
E
L
L
G
V
V
N
G
D
D
-----
T
T
A
A
L
T
E
A
G
L
R
T
S
A
E
F
G
P
D
A
M
F
-------------
R
L
V
S
E
W
C
A
A
-----
F
D
E
A
L
AGARS
A
D
D
V
L
A
A
P
R
V
V
P
P
E
Q
T
A
--
R
A
L
V
Q
P
R
F
A
T
LYDM
D
F
V
Q
D
G
L
R
Y
V
A
Q
H
T
--------------
N
W
A
L
P
L
A
L
A
V
R
Q
M
Q
NEGLK
P
L
T
R
A
L
F
A
L
T
I
A
D
E
F
-
F
H
D
RQN
P
T
L
R
-
E
Q
F
A
E
A
A
R
---------------------------
A
V
D
E
A
A
L
-
V
PVGEVNATP
R
T
A
V
E
V
R
V
S
A
A
L
A
H
G
D
AY
V
R
E
L
R
P
G
T
V
--
A
R
R
L
R
T
D
Q
G
V
L
A
L
L
---
D
---
P
G
A
-
Q
A
V
H
V
A
A
A
A
DL
D
H
T
Q
V
D
A
T
G
V
W
E
A
V
Q
A
S
A
--
S
P
--
L
Q
V
V
E
A
L
V
T
A
G
F
T
R
R
H
C
D
L
L
E
R
A
V
L
D
R
A
P
R
L
--
T
D
A
Q
R
A
V
G
C
T
A
V
V
G
G
V
V
H
R
L
L
D
D
Y
G
P
G
L
D
Y
V
R
A
Y
T
D
V
A
D
T
L
E
P
L
Y
G
D
V
T
A
A
L
G
L
P
E
K
G
V
E
H
V
V
R
H
C
M
A
P
R
P
P
T
E
H
V
G
A
A
R
A
A
-
L
L
R
E
V
A
A
A
E
R
R
A
GLAHS
A
A
R
E
A
L
N
T
W
L
A
F
R
A
Q
S
R
WGL
50
Fugue
72.05
21%
-50
* C4 *
1RR9
-
LON_ECOLI
A:
[10-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
---------------------------
Q
V
T
G
L
A
W
T
E
---------
V
G
G
D
L
L
T
I
E
T
A
C
V
P
G
K
G-
K
L
T
Y
T
G
S
L
G
--
E
V
M
Q
E
S
I
Q
A
A
L
T
-
V
---
V
---
R
A
R
A
E
K
L
G
I
N
P
D
---
F
Y
E
K
R
D
-----
I
H
V
H
V
P
E
--
G
A
--
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
--
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
---------------
F
E
N
K
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
-
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
E
P
--------------------------------
31
HHSearch
71.15
25%
-75
- C4 -
3K1J
1
?
A:
[480-578]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
V
E
G
D
A
A
S
I
S
V
A
T
A
V
I
S
A
L
E
G
I
P
I
R
--
Q
D
V
A
M
T
G
S
L
S
V
R
G
E
V
L
P
I
G
G
A
T
P
A
I
E
A
A
I
E
A
G
I
K
M
V
I
I
P
K
S
N
E
---------------
K
D
V
F
-
L
S
K
D
K
A
E
K
I
Q
I
F
P
-
V
E
T
I
D
E
V
L
E
I
-
A
L
E
E
S
--------------------------------
51
Fugue
70.75
15%
-41
- C4 -
3M6A
1
LON1_BACSU
A:
[7-531]
TGEVQ
T
L
T
E
K
I
E
EAGMPDHVK
E
T
A
L
K
E
L
N
R
YEKIPSSS
A
E
S
S
V
IRN
Y
I
D
W
L
V
A
LPWTDETD
D
K
L
D
LKE
A
G
R
L
L
D
E
E
HHGL
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
K
S
L
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
-
R
--
K
F
V
R
I
S
L
G
G
R
I
I
Q
G
M
K
K
A
--
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
A
M
-
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
YI
E
E
T
F
D
LS
K
V
L
F
I
A
T
A
N
NLATI
P
G
P
-----------
L
R
D
R
-----
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
------
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
GLKKSN
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
-----
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
------
V
-
A
E
E
R
K
R
I
T
V
T
EKNLQDFIGKRIFRYGQA
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
-
T
---------
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
--
K
G
K
L
I
L
T
G
K
LG
D
V
M
R
E
S
A
Q
A
A
F
S
-
Y
V
R
S
K
---
T
E
E
-
L
G
I
E
P
D
F
H
---
E
K
Y
D
I
H
-----
I
H
V
P
E
----
G
A
--
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
--
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
---------------
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
-
A
S
H
L
D
E
V
L
E
H
-
A
L
V
----------------------------------
28
HHSearch
69.09
23%
-84
- C4 -
3WU4
-
?
A:
[81-188]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
H
V
--
P
E
GA
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
--
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
---------------
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
-
V
K
R
I
E
E
V
L
T
L
-
A
L
Q
N
---------------------------------
33
HHSearch
66.16
36%
-68
* C3 *
3I18
1
?
A:
[5-92]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
D
G
V
Y
V
M
S
V
K
D
D
V
P
A
A
D
------
V
-
L
H
A
G
D
L
I
T
---------------------------
E
I
D
G
N
A
F
-
K
---------
S
S
Q
E
F
I
D
Y
I
H
S
K
K
V
G
D
--
T
V
K
I
N
Y
K
H
G
--
D
K
-
N
E
-
Q
A
D
I
K
L
-
T
---
A
IDK
K
G
T
-
P
G
I
G
I
T
L
V
---
D
D
L
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
64.06
35%
-43
- C3 -
2KJK
-
?
A:
[1-100]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
K
-----
V
T
Y
D
G
V
Y
V
L
S
V
K
E
D
V
P
A
A
G
------
I
-
L
H
A
G
D
L
I
T
---------------------------
E
I
D
G
Q
S
F
-
K
---------
S
S
Q
E
F
I
D
Y
I
H
S
K
K
V
G
D
--
T
V
K
I
K
Y
K
H
G
--
N
K
N
E
E
A
S
I
K
L
T
A
-
I
D
--
K
---
K
G
T
-
P
G
I
G
I
T
L
V
---
D
D
L
E
H
H
-----
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
62.29
22%
-76
- C4 -
1Z0W
2
A:
[89-187]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
V
E
G
D
S
A
S
I
S
I
A
T
A
V
I
S
A
I
E
G
I
P
V
D
--
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
---------------
D
D
V
L
-
L
D
A
E
H
E
G
K
I
E
V
I
P
-
V
S
R
I
N
E
V
L
E
H
-
V
L
E
D
G
--------------------------------
27
HHSearch
61.45
23%
-71
- C4 -
1XHK
-
LONB_METJA
A:
[82-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
Q
F
--
S
Q
SY
S
K
I
D
G
D
S
A
T
A
A
V
C
L
A
I
I
S
A
L
L
D
I
P
L
K
--
Q
D
F
A
I
T
G
S
L
D
L
S
G
N
V
L
A
I
G
G
V
N
E
K
I
E
A
A
K
R
Y
G
F
K
R
V
I
I
P
E
A
N
M
---------------
I
D
V
I
E
-----
T
E
G
I
E
I
I
P
-
V
K
T
L
D
E
I
V
P
L
-
V
F
D
L
D
--------------------------------
1
PsiBlast_PDB
61.17
37%
-42
- C3 -
2KJK
-
?
A:
[2-94]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
-----
V
T
Y
D
G
V
Y
V
L
S
V
K
E
D
V
P
A
A
G
------
I
-
L
H
A
G
D
L
I
T
---------------------------
E
I
D
G
Q
S
F
-
K
---------
S
S
Q
E
F
I
D
Y
I
H
S
K
K
V
G
D
--
T
V
K
I
K
Y
K
H
G
--
N
K
N
E
E
A
S
I
K
L
T
A
-
I
---
D
K--
K
G
T
-
P
G
I
G
I
T
L
V
---
D
D
L
E
H
H
-----
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
59.90
19%
-68
- C4 -
3M6A
-
LON1_BACSU
A:
[433-531]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
--
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
---------------
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
-
A
S
H
L
D
E
V
L
E
H
-
A
L
V
----------------------------------
29
HHSearch
58.04
20%
-65
- C4 -
2X36
-
LONM_HUMAN
A:
[849-948]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
K
D
G
P
S
A
G
C
T
I
V
T
A
L
L
S
L
A
M
G
R
P
V
R
--
Q
N
L
A
M
T
G
E
V
S
L
T
G
K
I
L
P
V
G
G
I
K
E
K
T
I
A
A
K
R
A
G
V
T
C
I
V
L
P
A
E
N
K
---------------
K
D
F
Y
D
L
A
A
F
I
T
E
G
L
E
V
H
F
-
V
E
H
Y
R
E
I
F
D
I
-
A
F
P
----------------------------------
2
PsiBlast_PDB
57.34
36%
-64
- C3 -
3I1E
-
?
A:
[3-82]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
Y
V
L
S
V
K
E
D
V
P
A
A
G
------
I
-
L
H
A
G
D
L
I
T
---------------------------
E
I
D
G
Q
S
F
-
K
---------
S
S
Q
E
F
I
D
Y
I
H
S
K
K
V
G
D
--
T
V
K
I
K
Y
K
H
G
--
N
K
N
E
E
A
S
I
K
L
T
A
-
I
---
D
K--
K
G
T
-
P
G
I
G
I
L
E
H
---
H
H
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.22
29%
-50
- C4 -
1Z0E
-
LONB_ARCFU
A:
[493-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
H
I
Q
F
VG
T
Y
--
E
G
V
E
G
D
S
A
S
I
S
I
A
T
A
V
I
S
A
I
--
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
---------------------------------------------------------------------------------
3
PsiBlast_PDB
56.18
30%
-38
- C3 -
2KL1
-
?
A:
[5-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
Y
V
M
S
V
L
P
N
M
P
A
A
G
------
R
-
L
E
A
G
D
R
I
A
---------------------------
A
I
D
G
Q
P
I
-
N
---------
T
S
E
Q
I
V
S
Y
V
R
E
K
Q
A
G
D
--
R
V
R
V
T
F
I
R
D
--
R
K
Q
H
E
A
E
L
V
L
K
P
-
F
---
P
---
H
H
P
-
N
Q
I
G
L
G
V
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.36
29%
-52
- C4 -
1Z0G
-
LONB_ARCFU
A:
[493-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
H
I
Q
F
V
G
T
Y
--
E
G
V
E
G
D
S
A
S
I
S
I
A
T
A
V
I
S
A
I
--
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
---------------------------------------------------------------------------------
13
PsiBlast_PDB
55.23
29%
-76
- C4 -
3K1J
2
?
A:
[470-546]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
H
V
Q
F
LQ
T
Y
--
E
G
V
E
G
D
A
A
S
I
S
V
A
T
A
V
I
S
A
L
E
G
I
P
I
R
Q
--
D
V
A
M
T
G
S
L
S
V
R
G
E
V
L
P
I
G
G
A
T
P
A
I
E
A
A
I
E
A
G
I
K
M
V
I
I
P
K
S
N
E
K
D
V
F
L
S
K
D
K
A
E
K
I
Q
I
F
P
V
E
T
I
D
E
V
L
E
I
A
L
E
E
S
E
-
K
K
R
E
L
L
R
R
I
R
-
E
T
L
P
L
--------------------------------
6
PsiBlast_PDB
53.45
29%
-51
- C4 -
1Z0C
-
LONB_ARCFU
A:
[493-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
H
I
Q
F
V
G
T
Y
--
E
G
V
E
G
A
S
A
S
I
S
I
A
T
A
V
I
S
A
I
--
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
---------------------------------------------------------------------------------
10
PsiBlast_PDB
53.21
29%
-49
- C4 -
1Z0T
-
LONB_ARCFU
A:
[493-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
H
I
Q
F
VG
T
Y
--
E
G
V
E
G
D
S
A
S
I
S
I
A
T
A
V
I
S
A
I
--
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
---------------------------------------------------------------------------------
37
HHSearch
52.91
25%
-14
- C3 -
3STJ
1
DEGQ_ECOLI
A:
[263-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
A
F
V
S
E
V
L
P
G
S
G
S
A
K
------
A
G
V
K
A
G
D
I
I
T
---------------------------
S
L
N
G
K
P
L
-
N
---------
S
F
A
E
L
R
S
R
I
A
T
T
E
P
G
T
--
K
V
K
L
G
L
L
R
N
--
G
K
-
P
L
-
E
V
E
V
T
L
-
D
---
T
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------