@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0537: (2015-12-01 )
MNFSFLPQYWSYFNYGVMVTIMISTCVVFFGTIIGVLIALVKRTNLHFLTILANFYVWVFRGTPMVVQIMIAFAWMHFNNLPTISFGVLDLDFTRLLPGIIIISLNSGAYISEIVRAGIEAVPSGQIEAAYSLGIRPKNTLRYVILPQAFKNILPALGNEFITIIKDSALLQTIGVMELWNGAQSVVTATYSPVAPLLFAAFYYLMLTTILSALLKQMEKYLGKGVKIDG
Atome Classification :
(20 SA)
------------------------------.........10...-.....20..---......30...-------------------.....40--......-------.---..50.-------....------...-----60...---.....70..-....-..-80-..-....-..90----------.-------.......---.--------100-.....----..110.......120.......130.......140.......150.......160.......170.......180.......---190....--...200-------------------------------------------.........210.......220....------...230----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MNF
S
F
L
P
Q
Y
W
S
Y
FN-Y
G
V
M
V
T
I
M
I
---
S
T
C
V
V
F
F
G
T
I
I
-------------------
G
V
L
I
A
L
---
V
KRTN
L
-------
H
---
F
L
T
I
L
-------
A
N
F
Y
------
V
W
V
-----FRGT
P
---
M
V
V
Q
I
M
I
A
F
-
A
W
M
H
-FN-NL-P
T
-
I
S
F
G
-
V
LD-----------
L
-------
D
F
T
R
LLP---
G
--------
I
I
I
-
I
SLNS----
G
A
Y
I
S
E
I
V
R
A
G
I
E
AVPSGQ
I
E
A
A
Y
SLGIRPKN
T
L
R
Y
V
I
L
P
Q
A
F
K
N
I
L
P
A
LG
N
E
F
I
T
I
IK
D
S
A
L
L
Q
T
I
G
V
M
E
L
WNG
A
Q
S
V
V
T
A---TYSP
V
A
P
--
L
L
F
A
---------------------------------------------
A
F
Y
Y
L
M
L
T
T
I
L
S
A
L
L
K
Q
M
E
K
Y
LGKGV------KIDG------------------------------
25
Fugue
91.96
37%
-145
- C4 -
4YMU
2
?
C:
[1-214]
----------------------------MT
V
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
-
N
G
L
M
---------------
Q
F
G
-----------
M
-------
N
I
P
A
F
T
A
---
G
--------
V
S
A
-
L
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
--------------------------------------------
14
PsiBlast_CBE
90.56
38%
-134
- C4 -
4YMT
2
?
B:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
5
PsiBlast_PDB
90.52
38%
-133
- C4 -
4YMW
2
?
D:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
13
PsiBlast_CBE
90.24
38%
-132
- C4 -
4YMU
2
?
C:
[4-214]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
--------------------------------------------
3
PsiBlast_PDB
90.21
38%
-134
- C4 -
4YMU
2
?
D:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
1
PsiBlast_PDB
89.86
38%
-133
- C4 -
4YMS
-
?
D:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
2
PsiBlast_PDB
89.67
38%
-133
- C4 -
4YMT
2
?
C:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
12
PsiBlast_CBE
89.37
38%
-133
- C4 -
4YMW
2
?
C:
[4-214]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
--------------------------------------------
4
PsiBlast_PDB
88.95
38%
-132
- C4 -
4YMV
-
?
D:
[4-215]
-------------------------------
D
F
L
S
M
V
K
Y
T
P
L
F
I
-
S
G
L
I
M
T
L
K
L
---
T
F
L
A
V
T
I
G
V
L
M
-------------------
G
L
F
I
A
L
---
M
K
M
S
S
I
-------
K
---
P
I
K
L
V
-------
A
S
S
Y
------
I
E
V
-----
I
R
G
T
P
---
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
-
P
A
-
F
T
A
G
-
V
S
A
-----------
L
-------------------------------
A
I
N
S
----
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
---
T
Y
R
Y
F
E
P
--
Y
I
I
I
---------------------------------------------
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
-------------------------------------------
26
Fugue
66.03
19%
-122
- C4 -
3DHW
-
METI_ECOLI
A:
[6-208]
-----------------------------------
M
W
L
L
V
R
G
V
W
-
E
T
L
A
M
T
F
V
S
---
G
F
F
G
F
V
I
G
L
P
V
-------------------
G
V
L
L
Y
V
---
T
R
P
G
Q
I
-------
I
ANA
K
L
Y
R
T
-------
V
S
A
I
------
V
N
I
-----
F
R
S
I
P
---
F
I
I
L
L
V
W
M
I
-
P
F
T
R
-
V
I
-
V
G
-
T
S
-
I
G
-----------------------------
L
Q
A
---
A
--------
I
V
P
-
L
T
V
G
A
----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
--------------------------------------------------------
T
V
M
N
T
V
L
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
------------------------------------------
17
HHSearch
65.33
18%
-119
- C4 -
3TUI
-
METI_ECOLI
A:
[3-216]
------------------------------------
E
P
M
M
W
L
L
V
-
R
G
V
W
E
T
L
A
M
---
T
F
V
S
G
F
F
G
F
V
I
-------------------
G
L
P
V
G
V
---
L
L
Y
V
T
R
PGQIIAN
A
---
K
L
Y
R
T
-------
V
S
A
I
------
V
N
I
-----
F
R
S
I
P
---
F
I
I
L
L
V
W
M
I
-
P
F
----
T
-
R
V
-
I
---
V
-----
G
-------------------
T
S
I
G
L
Q
A
---
A
--------
I
V
P
-
L
T
V
G
A
----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
-
T
V
--
M
N
T
V
---------------------------------------------
L
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
R
I
V
R
A
V
T
R
------------------------------------------
27
Fugue
65.18
16%
-109
- C4 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
MRLLFSALLALLSSIILLFVLLPVAATVTL
Q
L
F
N
F
D
E
F
L
K
A
A
S
D
-
P
A
V
W
K
V
V
L
T
---
T
Y
Y
A
A
L
I
S
T
L
I
-------------------
A
V
I
F
G
T
---
P
L
A
Y
I
L
-------
A
---
R
K
S
F
P
-------
G
K
S
V
------
V
E
G
-----
I
V
D
L
P
---
V
V
I
P
H
T
V
A
G
-
I
A
L
L
-
V
V
-
F
G
-
S
S
-
G
L
I
G
S
F
S
P
-----------
L
-------
K
F
V
D
A
L
P
---
G
--------
I
V
V
A
M
L
F
V
S
----
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
------
Y
Y
P
M
I
--------
A
P
T
L
I
--
Y
E
R
Y
---------------------------------------------
L
S
E
G
L
S
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
------
R
I
I
V
G-----------------------------
30
Fugue
59.94
15%
-184
- C4 -
4D79
5
TCDA_ECOLI
A:
[3-268]
----------------------------VV
I
S
D
A
W
R
Q
R
F
G
G
T
A
R
L
Y
G
E
K
A
L
Q
L
F
A
D
A
H
I
C
V
V
G
I
G
G
V
G
-------------------
S
W
A
A
E
A
---
L
A
R
T
G
I
-------
G
---
A
I
T
L
I
D
MDDVCV
T
N
T
N
------
R
Q
I
HALRD
N
V
G
L
A
---
K
A
E
V
M
A
E
R
I
-
R
Q
I
N
-
P
E
C
R
V
-
T
V
-
V
D
D
F
-
V
T
P
-----------
D
-------
N
V
A
Q
Y
M
S
---
V
GYS-----
Y
V
I
-
D
A
I
D
S
V
R
P
K
A
A
L
I
A
Y
C
R
R
N
K
I
P
L
V
T
T
G
--------
G
A
G
G
Q
I
D
P
T
Q
I
Q
V
T
D
L
A
K
T
I
Q
D
P
L
A
A
K
L
R
E
R
L
K
S
D
F
G
V
V
K
N
S
K
G
K
L
--
G
V
D
C
V
F
S
T
EAL
V
Y
P
G
F
G
A
A
T
M
V
T
A
---------------------------------------------
T
F
G
F
V
A
V
S
H
A
L
K
K
M
M
A
K
A
A
R
--------------
Q
G
------------------------------
29
Fugue
59.78
24%
-122
- C2 -
2Y38
8
LAMA5_MOUSE
A:
[8-398]
-------------------------------
G
F
S
L
H
P
---
P
Y
F
N
-
L
A
E
G
A
R
I
T
A
---
S
A
T
C
H
P
V
S
N
A
I
DGTE
R
W
W
Q
S
PPLSRGLEYN
E
V
N
V
T
L
---
D
L
G
Q
V
F
-------
H
---
V
A
Y
V
L
-------
I
K
F
A
NSPRPD
L
W
V
-----
L
E
R
S
T
DFG
H
T
Y
Q
P
W
Q
F
F
-
A
S
S
K
-
R
D
-
C
L
-
E
R
-
F
G
P
R
-
T
L
E
RITQDD
D
V
I
C
T
T
-------
E
Y
S
R
I
V
P
LEN
G
--------
E
I
V
-
V
S
L
V
N
----
G
R
-
P
G
A
L
N
F
S
Y
S
P
L
L
R
D
F
T
K
A
T
N
I
R
L
R
F
L
R
T
N
T
L
L
G
H
L
M
G
K
A
L
R
D
--
P
T
V
T
R
R
Y
Y
Y
S
I
K
D
----
I
S
I
G
G
R
C
V
C
H
G
H
A
D
V
C
D
A
---
K
-
D
P
L
D
P
--
F
R
L
Q
CACQHNTCGGSCDRCCPGFNQQPWKPATTDSAN
E
C
Q
S
C
N
CHGHAY
D
C
Y
Y
D
P
E
V
D
R
R
E
A
S
Q
N
Q
D
N
V
Y
Q
G
G
G
V
C
L
DCQH
H
T
T
G
INCERCLPGFFRAPDQPLDSPHVCRPAAAH
8
PsiBlast_PDB
58.11
26%
-115
- C4 -
3TUZ
-
METI_ECOLI
A:
[4-161]
------------------------------------
P
M
M
W
L
L
V
R
--
G
V
W
E
T
L
A
M
---
T
F
V
S
G
F
F
G
F
V
I
-------------------
G
L
P
V
G
V
L
L
Y
V
T
R
P
G
--------------
Q
I
I
-------
A
N
--------
A
K
L
-----
Y
R
T
V
S
---
A
I
V
N
I
----------
F
R
-
S
I
-
P
F
-
I
I
L
L
-
V
W
M
-----------
I
-------
P
F
T
R
V
I
V
---
G
TSIGLQAA
I
V
P
-
L
T
V
G
A
----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
T
V
M
--
N
T
V
L
---------------------------------------------
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
R
I
V
R
A
V
T
R
-------------------------------------------
7
PsiBlast_PDB
57.96
26%
-117
- C4 -
3TUI
-
METI_ECOLI
A:
[4-161]
------------------------------------
P
M
M
W
L
L
V
R
--
G
V
W
E
T
L
A
M
---
T
F
V
S
G
F
F
G
F
V
I
-------------------
G
L
P
V
G
V
L
L
Y
V
T
R
P
G
--------------
Q
I
I
-------
A
N
--------
A
K
L
-----
Y
R
T
V
S
---
A
I
V
N
I
----------
F
R
-
S
I
-
P
F
-
I
I
L
L
-
V
W
M
-----------
I
-------
P
F
T
R
V
I
V
---
G
TSIG
L
Q
A
A
I
V
P
-
L
T
V
G
A
----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
T
V
M
--
N
T
V
L
---------------------------------------------
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
R
I
V
R
A
V
T
R
-------------------------------------------
16
HHSearch
56.67
13%
-118
- C4 -
2ONK
-
WTPB_ARCFU
C:
[67-275]
---------------------------------------
D
P
A
V
W
-
K
V
V
L
T
T
Y
Y
A
---
A
L
I
S
T
L
I
A
V
I
F
-------------------
G
T
P
L
A
Y
---
I
L
A
R
K
S
-------
F
---
P
G
K
S
V
-------
V
E
G
I
------
V
D
L
-----
P
V
V
I
P
---
H
T
V
A
G
I
A
L
L
-
V
V
F
G
-
S
S
-
G
-----
L
I
G
S
-
F
S
P
-----------
L
K------
F
V
D
A
L
P
G
---
I
--------
V
V
A
-
M
L
F
V
S
----
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
Y
Y
P
M
I
A
P
T
L
I
Y
E
R
Y
L--
S
E
G
L
S
A
---
A
M
P
V
---------------------------------------------
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
----------------------------------------------
15
HHSearch
55.31
12%
-116
- C4 -
3D31
-
?
C:
[78-283]
----------------------------------------
R
S
V
I
-
S
S
I
F
L
S
L
Y
A
---
G
F
L
A
T
L
L
A
L
L
L
-------------------
G
A
P
T
G
Y
---
I
L
A
R
F
D
-------
F
---
P
G
K
R
L
-------
V
E
S
I
------
I
D
V
-----
P
V
V
V
P
---
H
T
V
A
G
I
A
L
L
-
T
V
F
G
-
S
R
-
G
L
-
I
G
E
P
L
E
S
--
Y
I
-----------
Q
-------
F
R
D
A
L
P
G
---
I
--------
V
V
A
-
M
L
F
V
S
----
M
P
Y
L
A
N
S
A
R
E
G
F
K
S
V
D
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
W
A
R
A
I
S
E
F
G
A
V
V
I
L
A
Y
Y
P
M
V
G
P
T
L
I
Y
D
R
F
I--
S
Y
G
L
S
A
S
--
R
-
P
I
---------------------------------------------
A
V
L
L
I
L
V
T
L
S
I
F
L
V
I
R
--------------------------------------------------
6
PsiBlast_PDB
54.92
26%
-110
- C4 -
3DHW
-
METI_ECOLI
A:
[6-161]
--------------------------------------
M
W
L
L
V
R
--
G
V
W
E
T
L
A
M
---
T
F
V
S
G
F
F
G
F
V
I
-------------------
G
L
P
V
G
V
LLY
V
T
R
P
G
--------------
Q
I
I
-------
A
N
--------
A
K
L
-----
Y
R
T
V
S
---
A
I
V
N
I
----------
F
R
-
S
I
-
P
F
-
I
I
L
L
-
V
W
M
-----------
I
-------
P
F
T
R
V
I
V
---
G
TSIG
L
Q
A
A
I
V
P
-
L
T
V
G
A
----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
T
V
M
--
N
T
V
L
---------------------------------------------
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
---------------------------------------------------
18
HHSearch
53.10
16%
-128
- C4 -
3RLF
2
MALF_ECOLI
F:
[276-450]
-----------------------------------------
P
F
L
-
A
I
F
V
W
T
V
V
F
---
S
L
I
T
V
F
L
T
V
A
V
-------------------
G
M
V
L
A
C
---
L
V
Q
W
E
A
-------
L
---
R
G
K
A
V
-------
Y
R
V
L
------
L
I
L
-----
P
Y
A
V
P
---
S
F
I
S
I
L
I
F
K
-
G
L
F
N
Q
S
F
-
G
E
I
N
M
-
M
L
S
A
-
L
F
G
-----------
V
KPAWFSD
P
T
T
A
R
T
M
---
L
--------
I
I
V
-
N
T
W
L
G
----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
P
D
R
L
G
T
T
T
P
A
G
---
Y
T
D
L
L
V
N
--
Y
T
Y
R
---------------------------------------------
I
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
------
A
L
A
I
------------------------------