@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0564: (2015-12-01 )
MEEEIALLENQMTEPDFWNDNIAAQKTSQELNELKGKYDTFHNMQELSDETELLLEMLDEDDSLKEELEENLMQLDKIMGAYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDLLLRMYTRFGNANGFKVEVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFASVEVMPELDDTIEVEVRDDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVSSTVDRTQYGNRDRAMKMLQAKLYQLEQEKKAQEVDALKGDKKEITWGSQIRSYVFTPYTMVKDHRTNFELAQVDKVMDGEINGFIDAYLKWRIED
Atome Classification :
(20 SA)
--------------------------.....--------....10------....-.-------------------..-.20..------......30.......-----------.40..-......50----------.....---...60-.........--70.......---.80---...----.-.-.---..90.--......-----.100----------------.......110..------.-....120........130------......---.------.140....-...150.......160.----------......170-------.......-------..-------------------180......-----.190....----------...200-------.........210--.....--.-..220.......230.--------------------.---------------------.------.-----.-----------------.---.-.240.......250.....-...260..--.----....-.270----.......--280-.......----.--290.---......300.......310-----...-----.....320.......330.....------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------ME
E
E
I
--------
A
L
L
E
NQ------MTEP-D-------------------FW-NDNIA------
A
Q
K
T
S
Q
E
L
N
E
LKGK
Y
-----------
D
T
F
H
N
-
M
Q
E
LS
D
E
T
----------
E
L
L
L
E
---
M
LDE--D
D
S
L
K
E
E
L
E
--
E
N
L
M
Q
L
D
K
I
---
M
G
A
---
Y
E
M
----
T
-
L
-
L
---LSEPY--DHN
N
A
I
-----
L
E
I
H----------------PGSGGT
E
A
Q
D
W
G
------
D
-
L
L
L
R
M
-
Y
T
R
FGNAN
G
F
K
-------
V
E
V
L
D
Y---Q------AGDEAG
I
K
-
S
V
T
L
S
FEGPNAY
G
L
L
K
S
----------EMGV
H
R
L
---------
V
R
ISPF
D
-------
S
A
-------------------
K
RRHTSFA
S
-----
V
E
VMPELD----------
D
T
I
E
---------
V
E
VRDDDI
K
M
D
---
T
FRSG--G-AGGQN
V
N
KVSTG
V
-
R
L
--------------------T---------------------H------I-----P-----------------T---
G
-
I
V
V
S
STVDRTQY-G
N
R
D
R
A
-
M
K
M
L
-
Q
A
K
--
L
----
Y
Q
L
E
-
Q
E
K
K
----
A
Q
E
V
D
AL--KG--DKKEI
T
W
----
G
--
S
Q
I
R
---
S
YVFT
P
Y
T
M
V
KDHRTNF
E
------
L
A
Q
-----
V
D
K
VMDGE
I
N
G
F
I
D
A
Y
L
K
W
R
IED------
4
PsiBlast_PDB
88.75
38%
-59
- C4 -
1RQ0
-
RF1_THEMA
A:
[30-327]
------------------------------------------------------------------------------------------------------
A
K
I
-----------
E
E
I
E
N
-
I
T
N
R
I
K
E
T
----------
Q
E
F
I
E
---
L
L
R
E
--
E
G
E
N
E
L
E
I
E
--
K
Y
E
K
E
L
D
Q
L
---------
Y
Q
E
----
L
-
L
-
F
---
L
L
S
P
E
--
A
S
D
K
A
I
-----
V
E
I
R
----------------
P
G
T
G
G
E
E
A
A
L
F
A
------
R
-
D
L
F
R
M
-
Y
T
R
Y
A
E
R
K
G
W
N
-------
L
E
V
A
E
I
---
H
------
E
T
D
L
G
G
I
R
-
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
----------
E
S
G
V
H
R
V
---------
Q
R
V
P
V
T
E
-------
S
G
-------------------
G
R
I
H
T
S
T
A
T
-----
V
A
V
L
P
E
I
E
----------
E
K
-
D
---------
I
E
I
R
P
E
D
L
K
I
E
---
T
F
R
A
S
--
G
-----
Y
V
N
K
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
-
Q
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
--
L
----
Y
Q
L
Q
-
K
E
Q
K
----
E
R
E
I
S
Q
-------------------RS
E
K
I
R
---
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
N
Y
T
------
S
Y
R
-----
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
------
19
HHSearch
88.70
36%
-57
- C4 -
1RQ0
-
RF1_THEMA
A:
[1-326]
--------------------------
M
K
E
K
K
--------
K
E
I
E
K
L
------
L
A
R
P
-
D
-------------------
L
T
-
P
E
--
Q
------
M
K
N
Y
G
M
E
Y
A
K
I
E
E
I
E
-----------
N
I
T
N
R
-
I
K
E
----
T
----------
Q
E
F
I
E
---
L
L
R
E
---
E
---
G
E
N
E
--
L
E
I
E
K
Y
E
K
E
---
L
D
Q
---
L
Y
Q
----
E
L
L
-
F
---
L
L
S
P
E
--
A
S
D
K
A
I
-----
V
E
I
R
----------------
P
G
T
G
G
E
E
A
A
L
F
A
------
R
-
D
L
F
R
M
-
Y
T
R
Y
A
E
R
K
G
W
N
-------
L
E
V
A
E
I
---
H
------
E
T
D
L
G
G
I
R
-
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
----------
E
S
G
V
H
R
V
---------
Q
R
V
P
V
T
E
-------
S
G
-------------------
G
R
I
H
T
S
T
A
T
-----
V
A
V
L
P
E
I
E
-----------
E
K
D
---------
I
E
I
R
P
E
D
L
K
I
E
---
T
F
R
A
S
--
G
-----
Y
V
N
K
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
-
Q
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
--
L
----
Y
Q
L
Q
-
K
E
Q
K
----
E
R
E
I
S
Q
--------------R---
S
--
E
K
I
R
---
T
Y
N
F
P
Q
-
N
R
V
T
D
H
R
I
N
Y
T
------
S
Y
R
-----
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
------
17
HHSearch
83.19
32%
-58
- C4 -
2B3T
-
RF1_ECOLI
B:
[12-350]
--------------------------
L
H
E
R
H
--------
E
E
V
Q
A
L
------
L
G
D
A
-
Q
-------------------
T
I
-
A
D
Q
E
R
------
F
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
-----------
R
C
F
T
D
-
W
Q
Q
V
-----------------------------------------------------------
Q
QLQV
L
-
L
-
L
---
P
K
D
P
D
--
D
E
R
N
A
F
-----
L
E
V
R
----------------
A
G
T
G
G
D
E
A
A
L
F
A
------
G
-
D
L
F
R
M
-
Y
S
R
Y
A
E
A
R
R
W
R
-------
V
E
I
M
S
A
---
S
------
E
G
E
H
G
G
Y
K
-
E
I
I
A
K
I
S
G
D
G
V
Y
G
R
L
K
F
----------
E
S
G
G
H
R
V
---------
Q
R
V
P
A
T
E
-------
S
Q
-------------------
G
R
I
H
T
S
A
C
T
-----
V
A
V
M
P
E
L
P
----------
D
A
E
L
---------
P
D
V
N
P
A
D
L
R
I
D
---
T
F
R
S
S
--
G
-
A
G
G
Q
H
V
N
T
T
D
S
A
I
-
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
E
C
Q
D
E
R
S
Q
H
-
K
N
K
A
K
A
-
L
S
V
L
-
G
A
R
--
I
----
H
A
A
E
-
M
A
K
R
----
Q
--------
R
R
--
N
----------
S
--
D
R
N
R
---
T
Y
N
F
P
Q
-
G
R
V
T
D
H
R
I
N
L
T
------
L
Y
R
-----
L
D
E
V
M
E
G
K
L
D
M
L
I
E
P
I
I
Q
E
H
Q
A
D
------
15
HHSearch
81.17
44%
17
- C4 -
1GQE
-
RF2_ECOLI
A:
[30-364]
--------------------------
K
K
E
R
L
--------
E
E
V
N
A
E
------
L
E
Q
P
-
D
-------------------
V
W
-
N
E
P
E
R
------
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
-----------
D
T
L
D
Q
-
M
K
Q
G
L
E
D
V
----------
S
G
L
L
E
---
L
A
V
E
A
D
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
L
E
E
K
---
L
A
Q
---
L
E
F
----
R
-
R
-
M
---
F
S
G
E
Y
--
D
S
A
D
C
Y
-----
L
D
I
Q
----------------
A
G
S
G
G
T
E
A
Q
D
W
A
------
S
-
M
L
E
R
M
-
Y
L
R
W
A
E
S
R
G
F
K
-------
T
E
I
I
E
E
---
S
------
E
G
E
V
A
G
I
K
-
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
----------
E
T
G
V
H
R
L
---------
V
R
K
S
P
F
D
-------
S
G
-------------------
G
R
R
H
T
S
F
S
S
-----
A
F
V
Y
P
E
V
D
----------
D
D
I
D
---------
I
E
I
N
P
A
D
L
R
I
D
---
V
Y
R
A
S
--
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
-
K
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
--
L
----
Y
E
V
E
-
M
Q
K
K
----
N
A
E
K
Q
A
M
--
E
D
--
N
K
S
D
I
G
W
----
G
--
S
Q
I
R
---
S
Y
V
L
D
D
-
S
R
I
K
D
L
R
T
G
V
E
------
T
R
N
-----
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
--------
26
Fugue
78.09
43%
23
- C4 -
1GQE
-
RF2_ECOLI
A:
[4-365]
IN
P
V
N
N
R
I
Q
D
L
T
E
R
S
D
V
L
R
G
Y
L
D
Y
D
A
K
K
E
R
L
--------
E
E
V
N
A
E
------
L
E
Q
P
-
D
-------------------
V
W
-
N
E
P
E
R
------
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
-----------
D
T
L
D
Q
M
K
Q
G
L
E
D
V
S
----------
G
L
L
E
L
---
A
V
E
A
D-
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
L
E
E
K
---
L
A
Q
---
L
E
F
----
R
-
R
M
F
----
S
G
E
Y
--
D
S
A
D
C
Y
-----
L
D
I
Q
----------------
A
G
S
G
G
T
E
A
Q
D
W
A
------
S
M
L
--
E
R
M
Y
L
R
W
A
E
S
R
G
F
K
-------
T
E
I
I
E
E
---
S
------
E
G
E
V
A
G
I
K
-
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
----------
E
T
G
V
H
R
L
---------
V
R
K
S
P
F
D
-------
S
G
-------------------
G
R
R
H
T
S
F
S
S
-----
A
F
V
Y
P
E
V
D
----------
D
D
I
D
---------
I
E
I
N
P
A
D
L
R
I
D
---
V
Y
R
A
S
--
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
-
K
N
K
D
Q
A
M
K
Q
--
M
K
A
K
--
L
----
Y
E
V
E
M
Q
K
K
N
----
A
E
K
Q
A
--M-
E
D
--
N
K
S
D
I
G
W
----
G
--
S
Q
I
R
---
S
Y
V
L
D
D
S
-
R
I
K
D
L
R
T
G
V
E
------
T
R
N
-----
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
--------
3
PsiBlast_PDB
77.98
44%
22
- C4 -
1GQE
-
RF2_ECOLI
A:
[40-362]
--------------------------------------------
E
------
L
E
Q
P
-
D
-------------------
V
W
-
N
E
P
E
R
------
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
-----------
D
T
L
D
Q
-
M
K
Q
G
L
E
D
V
----------
S
G
L
L
E
---
L
A
V
E
--
A
D
D
-
E
E
T
F
N
--
E
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
---
L
E
F
----
R
-
R
-
M
---
F
S
G
E
Y
--
D
S
A
D
C
Y
-----
L
D
I
Q
----------------
A
G
S
G
G
T
E
A
Q
D
W
A
------
S
-
M
L
E
R
M
-
Y
L
R
W
A
E
S
R
G
F
K
-------
T
E
I
I
E
E
---
S
------
E
G
E
V
A
G
I
K
-
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
----------
E
T
G
V
H
R
L
---------
V
R
K
S
P
F
D
-------
S
G
-------------------
G
R
R
H
T
S
F
S
S
-----
A
F
V
Y
P
E
V
D
----------
D
D
I
D
---------
I
E
I
N
P
A
D
L
R
I
D
---
V
Y
R
A
S
--
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
-
K
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
--
L
----
Y
E
V
E
-
M
Q
K
K
----
N
A
E
K
Q
A
M
--
E
D
--
N
K
S
D
I
G
W
----
G
--
S
Q
I
R
---
S
Y
V
L
D
D
-
S
R
I
K
D
L
R
T
G
V
E
------
T
R
N
-----
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
--------
6
PsiBlast_PDB
64.70
36%
16
- C4 -
1ZBT
-
RF1_STRMU
A:
[91-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
E
Y
E
--
E
K
L
R
F
L
---------------------
L
-
L
---
P
K
D
P
N
--
D
D
K
N
I
I
-----
L
E
I
R
----------------
G
A
A
G
G
D
E
A
A
L
F
A
------
G
-
D
L
L
N
M
-
Y
Q
K
Y
A
E
N
Q
G
W
K
-------
F
E
V
M
E
A
---
S
------
A
N
G
V
G
G
L
K
-
E
V
V
A
M
V
S
G
Q
S
V
Y
S
K
L
K
Y
----------
E
S
G
A
H
R
V
---------
Q
R
V
P
V
T
E
-------
S
Q
-------------------
G
R
V
H
T
S
T
A
T
-----
V
L
V
M
-
P
E
V
----------
E
E
V
E
---------
Y
E
I
D
P
K
D
L
R
V
D
---
I
Y
H
A
------------
K
V
A
T
A
V
-
R
I
--------------------
I
---------------------
H
------
L
-----
P
-----------------
T
---
N
-
I
K
V
E
M
Q
E
E
R
T
Q
Q
-
K
N
R
D
K
A
-
M
K
I
I
-
R
A
R
--
V
A
D
H
F
A
Q
I
A
-
Q
D
E
Q
----
D
A
----
T
VG
T
G
--
D
R
S
E
-----------
R
I
R
---
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
G
L
T
------
L
Q
K
-----
L
D
S
I
L
S
G
K
L
D
E
V
I
D
A
L
I
L
Y
D
Q
T
Q
------
1
PsiBlast_PDB
62.37
45%
159
- C- -
1ML5
1
RF2_ECOLI
Z:
[40-362]
--------------------------------------------
E
------
L
E
Q
P
-
D
-------------------
V
W
-
N
E
P
E
R
------
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
-----------
D
T
L
D
Q
-
M
K
Q
G
L
E
D
V
----------
S
G
L
L
E
---
L
A
V
E
--
A
D
D
-
E
E
T
F
N
--
E
A
V
A
E
L
D
A
L
EEK
L
A
Q
---
L
E
F
----
R
-
R
-
M
---
F
S
G
E
Y
--
D
S
A
D
C
Y
-----
L
D
I
Q
----------------
A
G
S
G
G
T
E
A
Q
D
W
A
------
S
-
M
L
E
R
M
-
Y
L
R
W
A
E
S
R
G
F
K
-------
T
E
I
I
E
E
---
S
------
E
G
E
V
A
G
I
K
-
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
----------
E
T
G
V
H
R
L
---------
V
R
K
S
P
F
D
-------
S
G
-------------------
G
R
R
H
T
S
F
S
S
-----
A
F
V
Y
P
E
V
D
----------
D
D
I
D
---------
I
E
I
N
P
A
D
L
R
I
D
---
V
Y
R
T
S
--
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
-
K
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
--
L
----
Y
E
L
E
-
M
Q
K
K
----
N
A
E
K
Q
A
M
--
E
D
--
N
K
S
D
I
G
W
----
G
--
S
Q
I
R
---
S
Y
V
L
D
D
-
S
R
I
K
D
L
R
T
G
V
E
------
T
R
N
-----
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
--------
2
PsiBlast_PDB
61.72
44%
159
- C- -
1MI6
-
RF2_ECOLI
A:
[40-362]
--------------------------------------------
E
------
L
E
Q
P
-
D
-------------------
V
W
-
N
E
P
E
R
------
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
-----------
D
T
L
D
Q
-
M
K
Q
G
L
E
D
V
----------
S
G
L
L
E
---
L
A
V
E
--
A
D
D
-
E
E
T
F
N
--
E
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
---
L
E
F
----
R
-
R
-
M
---
F
S
G
E
Y
--
D
S
A
D
C
Y
-----
L
D
I
Q
----------------
A
G
S
G
G
T
E
A
Q
D
W
A
------
S
-
M
L
E
R
M
-
Y
L
R
W
A
E
S
R
G
F
K
-------
T
E
I
I
E
E
---
S
------
E
G
E
V
A
G
I
K
-
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
----------
E
T
G
V
H
R
L
---------
V
R
K
S
P
F
D
-------
S
G
-------------------
G
R
R
H
T
S
F
S
S
-----
A
F
V
Y
P
E
V
D
----------
D
D
I
D
---------
I
E
I
N
P
A
D
L
R
I
D
---
V
Y
R
A
S
--
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
-
K
N
K
D
Q
A
-
M
K
Q
M
-
K
A
K
--
L
----
Y
E
V
E
-
M
Q
K
K
----
N
A
E
K
Q
A
M
--
E
D
--
N
K
S
D
I
G
W
----
G
--
S
Q
I
R
---
S
Y
V
L
D
D
-
S
R
I
K
D
L
R
T
G
V
E
------
T
R
N
-----
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
--------
35
Fugue
54.21
17%
-18
- C5 -
5A07
3
?
A:
[40-434]
------------------------D
H
D
A
E
V
L
--------
D
S
I
M
D
R
------
L
H
E
P
-
L
-------------------
Y
E
-
K
D
T
F
D
------
P
N
E
V
L
A
E
N
K
Q
L
Y
E
E
F
L
L
QEISEPKVD
N
L
V
R
S
-
G
D
P
L
A
G
K
A
----------
K
G
T
I
L
---
S
L
-
V
--
R
N
S
D
L
E
D
I
I
--
S
S
I
Q
Q
L
E
E
E
---
Y
N
K
NFG
Y
P
Y
----
T
-
F
-
L
---
N
D
E
E
F
T
D
E
F
K
D
G
I
-----
K
S
I
L
----------------
P
K
D
R
V
V
E
F
G
T
I
G
------
P
-
D
N
W
N
M
-
P
D
S
I
-
D
R
E
R
Y
D
-------
Q
E
M
D
K
M
---
S
K
E
NIQY
A
E
V
E
S
Y
H
N
-
M
C
R
F
Y
S
K
E
F
Y
H
H
P
L
L
S
K
----------
Y
K
Y
V
W
R
L
E
P
N
V
N
F
Y
C
K
I
N
Y
D
V
F
Q
-------
F
M
-------------------
N
K
N
D
K
I
Y
G
F
-----
V
L
N
L
Y
D
S
P
----------
Q
T
I
E
T
L
W
T
S
T
M
D
F
V
E
E
H
P
N
Y
L
N
V
N
GA
F
A
W
L
K
D
--
N
-
S
Q
N
P
K
N
Y
D
Y
T
Q
G
Y
-
S
T
--------------------
C
---------------------
H
------
F
-----
W
-----------------
T
---
N
-
F
E
I
V
D
-
L
D
F
L
R
S
-
E
P
Y
E
K
Y
-
M
Q
Y
L
-
E
E
K
GG
F
----
Y
Y
E
R
-
W
G
D
A
----
P
V
R
S
L
A
L
--
A
L
FA
D
K
S
S
I
H
W
FRDI
G
--
Y
H
H
T
---
P
Y
T
N
C
P
T
C
P
A
D
S
D
R
C
N
G
N
CVPGKF
T
P
W
-----
S
D
L
D
N
Q
N
C
Q
A
T
W
I
R
H
S
M
S
E
E
E
L
E
MY----
5
PsiBlast_PDB
52.36
38%
151
- C- -
2FVO
-
RF1_THEMA
A:
[30-327]
------------------------------------------------------------------------------------------------------
A
K
I
-----------
E
E
I
E
N
-
I
T
N
R
I
K
E
T
----------
Q
E
F
I
E
---
L
L
R
E
--
E
G
E
N
E
L
E
I
E
--
K
Y
E
K
E
L
D
Q
L
---------
Y
Q
E
----
L
-
L
-
F
---
L
L
S
P
E
--
A
S
D
K
A
I
-----
V
E
I
R
----------------
P
G
T
G
G
E
E
A
A
L
F
A
------
R
-
D
L
F
R
M
-
Y
T
R
Y
A
E
R
K
G
W
N
-------
L
E
V
A
E
I
---
H
------
E
T
D
L
G
G
I
R
-
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
----------
E
S
G
V
H
R
V
---------
Q
R
V
P
V
T
E
-------
S
G
-------------------
G
R
I
H
T
S
T
A
T
-----
V
A
V
L
P
E
I
E
----------
E
K
-
D
---------
I
E
I
R
P
E
D
L
K
I
E
---
T
F
R
A
S
--
G
----------
E
S
A
V
-
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
-
Q
N
K
Q
T
A
-
L
R
I
L
-
R
A
R
--
L
----
Y
Q
L
Q
-
K
E
Q
K
----
E
R
E
I
S
Q
-------------------RS
E
K
I
R
---
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
N
Y
T
------
S
Y
R
-----
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
------
34
Fugue
50.22
17%
-14
- C3 -
4O2X
-
MALE_ECOLI
A:
[5-483]
----------EG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
--------
K
K
F
E
K
D
TG
I
K
V
T
V
E
H
P
-
D
K
L
E
E
K
F
P
Q
V
A
A
T
GDGPD
I
I
F
W
A
H
D
R
F
G
------
G
Y
A
Q
S
G
L
L
A
E
I
T
P
D
K
-----------
A
F
Q
D
K
-
L
Y
P
F
T
W
D
A
V
RYNGKLI
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
--
K
D
L
L
P
N
P
P
K
TW
E
E
I
P
A
L
D
K
E
---
L
K
A
---
K
G
K
----
S
-
A
-
L
MFN
L
Q
E
P
Y
--
F
T
W
P
L
I
A
A
DGG
Y
A
F
K
----------------
Y
E
N
G
K
Y
D
I
K
D
V
G
VDN
A
G
A
K
-
A
G
L
T
F
-
L
V
D
L
I
K
N
K
H
M
N
-------
A
D
T
-
D
Y
---
S
------
I
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
----------
S
K
V
N
Y
G
V
---------
T
V
L
P
T
F
K
-------
G
Q
PSK
P
F
V
G
V
L
S
A
G
I
N
AASPN
K
E
L
A
K
E
F
L
E
N
YLLT
D
E
G
L
E
A
V
N
K
D
KPLGAVAL
K
S
Y
E
---------
E
E
L
A
K
D
P
R
I
A
A
---
T
M
E
N
A
--
Q
-
K
G
E
I
M
P
N
I
P
Q
M
S
A
-
F
W
--------------------
Y
---------------------
A
------
V
-----
R
-----------------
T
---
A
-
V
I
N
A
A
S
G
R
Q
T
V
D
-
E
A
L
A
A
A
-
Q
T
N
A
-
A
A
N
--
L
----
E
K
I
K
-
K
L
R
N
V
ITS
A
W
K
V
I
L
Y
--
N
D
--
D
I
H
N
F
T
Y
----
V
--
T
D
V
I
---
V
K
V
V
G
Q
I
S
K
A
K
A
H
T
I
T
V
E
------
A
H
S
TGQAL
I
L
S
T
W
K
S
K
A
E
K
Y
C
Q
E
L
Q
Q
N
G
L
T
V
S
I
I
H
ES
21
HHSearch
47.84
38%
-27
- C4 -
2JVA
-
?
A:
[6-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
---------
V
H
L
P
D
A
E
I
E
L
T
---
A
I
R
A
Q
--
G
-
A
G
G
Q
N
V
N
K
V
S
S
A
M
-
H
L
--------------------
R
---------------------
F
DINASS
L
-----
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
---
G
V
I
V
L
K
A
Q
Q
Y
R
T
Q
E
-
Q
N
R
A
D
A
-
L
L
R
L
-
S
E
L
--
I
----
V
N
A
A
-
K
L
E
H
----
H
H
H
H
H
------------------------------------------------------------------------------------------
24
HHSearch
47.76
33%
-48
- C4 -
2JY9
-
?
A:
[6-102]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
---------
V
S
I
A
D
N
E
L
E
I
T
---
A
I
R
A
Q
--
G
-
A
G
G
Q
H
V
N
K
T
S
S
A
I
-
H
L
--------------------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
-----
I
-----------------
S
DDG
V
-
I
I
I
K
A
Q
E
F
R
S
Q
E
-
L
N
R
E
A
A
-
I
A
R
L
-
V
A
V
--
I
----
K
E
L
T
-
A
E
Q
K
----
S
R
R
A
T
R
P
--
T
R
--
A
S
K
E
R
R
L
----
S
--
S
K
A
Q
---
K
S
S
V
K
A
L
R
G
K
V
R
R
P
L
D
L
E
------
H
H
H
-----
H
H
H
--------------------------
28
Fugue
46.54
14%
-11
- C4 -
3IBP
1
A:
[11-293]
---------------S
V
S
N
A
R
E
E
R
M
A
L
R
Q
E
Q
--------
E
Q
L
Q
S
R
------
I
Q
S
L
M
Q
-------------------
R
A
-
P
V
W
L
A
------
A
Q
N
S
L
N
Q
L
S
E
Q
C
G
E
-------------
E
F
T
S
-
S
Q
D
V
T
E
Y
L
----------
Q
Q
L
L
E
---
R
E
R
E
--
A
I
V
E
R
D
E
V
G
--
A
R
K
N
A
V
D
E
E
---
I
E
R
---
L
S
--------------
Q
P
G
G
--
S
E
D
Q
R
L
-----
N
A
L
A
----------------
E
R
F
G
G
V
L
L
S
E
I
------------------------------------
Y
D
D
---
V
------
S
L
E
D
A
P
Y
F
-
S
A
L
Y
---
G
P
S
R
H
A
I
V
------------------------------
V
P
D
L
S
-------
Q
V
-------------------
T
E
H
L
E
G
L
T
D
-----
C
P
-----
E
----------
D
L
Y
L
---------
I
E
G
D
P
Q
S
F
D
D
S
---
V
F
S
V
D
--
E
L
E
K
A
V
V
V
K
I
A
D
R
Q
W
-
R
Y
--------------------
S
---------------------
R
------
F
-----
P
-----------------
E
---
V
-
P
L
F
G
-------
R
-
A
A
R
E
S
R
-
I
E
S
L
-
H
A
E
--
R
----
E
V
L
S
-
E
R
F
A
----
T
L
S
F
D
V
Q
--
K
T
--
Q
R
L
H
Q
A
F
----
S
--
R
F
I
G
SHL
A
V
A
F
E
S
D
P
E
A
E
I
R
Q
L
N
S
R
------
R
V
E
-----
L
E
R
A
L
S
N
----------------------
29
Fugue
45.79
17%
1
* C7 *
4RNZ
9
?
A:
[1-369]
--------------------------
M
E
R
L
V
W
D
KLT
L
L
G
F
L
E
K
N
H
------
I
P
Q
K
-
L
-------------------
Y
Y
-
N
L
S
S
Q
------
D
K
E
L
S
A
E
I
Q
S
-
N
V
T
Y
-----------
Y
T
L
R
D
-
A
N
N
T
L
I
Q
A
----------
L
I
P
I
S
---
Q
-
D
L
--
Q
I
H
I
Y
K
K
G
E
--
D
Y
F
L
D
F
I
P
I
I
--
F
T
R
---
K
E
K
----
T
-
L
-
L
---
L
S
L
Q
T
--
S
P
Y
Q
D
I
-----
I
K
A
T
----------------
N
D
------
P
L
L
A
------
N
-
Q
L
M
N
A
-
Y
K
K
S
V
P
F
K
R
L
V
KN
D
K
I
A
I
V
Y
T
R
D
Y
R
VG
Q
------
A
F
G
Q
P
T
I
K
-
M
A
M
V
S
S
R
S
N
Q
Y
Y
L
F
S
H
S
NG
H
Y
Y
D
SKAQ
E
V
A
G
F
L
L
ETPVKY---
T
R
I
S
S
P
F
-------
S
Y
-------------------
G
R
F
H
R
P
H
Y
G
-----
V
D
Y
A
A
K
H
G
----------
S
L
I
H
----------
S
A
S
D
G
R
V
G
F
M
---
G
V
K
A
G
YG
K
-
V
V
E
I
H
L
N
E
L
R
L
V
Y
A
H
M
--------------------
S
---------------------
A
------
F
-----
A
-----------------
N
---
G
-
L
K
K
G
S
F
V
K
K
G
Q
I
I
G
R
V
G
S
T
-
G
P
H
L
-
H
F
G
--
V
----
Y
K
----
N
S
R
----
P
I
N
P
L
G
Y
--
I
R
--
T
A
K
S
K
L
H
----
G
--
K
Q
R
E
---
V
F
L
E
K
A
Q
R
S
K
Q
K
L
E
E
L
L
K
------
T
H
S
-----
F
E
K
N
S
F
Y
L
L
E
G
F
L
E
H
H
H
H
-----------
7
PsiBlast_PDB
45.43
33%
-32
- C4 -
2RSM
-
CL065_MOUSE
A:
[27-104]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
-----
V
Q
V
A
G
R
K
D
----------
Y
P
A
L
---------
L
P
L
N
E
S
E
L
E
E
Q
---
F
V
K
G
H
--
G
-
P
G
G
Q
A
T
N
K
T
S
N
C
V
-
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
V
D
-
Q
N
R
K
I
A
-
R
K
V
L
-
Q
E
K
--
V
----
D
V
F
Y
-
N
S
G
P
----
S
S
G
--------------------------------------------------------------------------------------------
20
HHSearch
45.27
26%
-24
- C4 -
2RSM
-
CL065_MOUSE
A:
[4-111]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
----------
G
K
W
G
L
R
L
---------
Q
E
K
P
A
L
L
-------
F
P
-------------------
G
-
M
A
A
S
T
V
Q
-----
V
A
G
R
K
D
Y
P
------------
A
L
---------
L
P
L
N
E
S
E
L
E
E
Q
---
F
V
K
G
H
--
G
-
P
G
G
Q
A
T
N
K
T
S
N
C
V
-
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
V
D
-
Q
N
R
K
I
A
-
R
K
V
L
-
Q
E
K
--
V
----
D
V
F
Y
-
N
S
G
P
----
S
S
G
--------------------------------------------------------------------------------------------
32
Fugue
43.28
12%
-8
- C7 -
5BTB
5
?
A:
[5-371]
--------------SELLLQA
T
T
A
L
K
Q
P
K
E
L
--------
G
Y
Y
S
T
N
------
V
G
G
E
-
L
-------------------
K
V
-
M
D
E
S
N
L
S
Y
Y
Y
L
P
D
A
D
I
E
K
H
I
D
L
S
A
G
A
-----------
R
K
F
Q
D
-
E
Q
A
E
A
E
D
D
----------
T
G
S
L
H
---
G
L
L
Q
--
T
L
M
E
Y
E
R
R
K
--
S
K
K
V
N
A
D
I
I
---
A
F
R
---
G
Q
V
----
K
-
R
-
L
---
I
H
C
A
F
--
G
G
H
A
T
D
-----
V
D
M
Y
V
M
S
F
DG
Q
L
F
I
R
A
ARK
K
L
E
F
P
T
S
P
R
E
S
W
A
------
Y
-
L
A
Y
Y
S
-
G
Y
K
F
E
R
M
A
L
L
D
-------
R
P
V
A
E
T
---
P
------
R
E
V
L
E
S
R
G
-
K
Q
V
V
R
-
N
G
P
Q
Y
K
T
V
V
R
T
----------
G
V
G
E
H
K
L
---------
V
L
G
A
E
V
D
G
I
F
DFRE
P
T
-------------------
G
D
N
L
K
H
Y
V
E
-----
L
K
V
A
K
K
V
Q
----------
T
L
K
D
---------
A
T
N
F
E
Q
K
L
F
S
V
---
W
L
Q
C
F
--
L
-
V
G
---
I
N
R
V
I
I
G
F
-
R
D
--------------------
E
---------------------
K
FV----
L
-----
K
-----------------
S
---
V
-
E
E
F
S
T
S
E
I
P
L
L
L
-
N
A
C
V
D
A
-
I
K
W
Y
-
G
A
L
--
T
----
K
W
L
C
-
E
L
P
R
----
G
P
E
D
D
----------------------
F
K
L
Y
---
R
L
S
C
S
R
G
A
L
H
L
R
Q
L
H
D
E
D
------
L
A
N
-----
G
D
D
I
I
-------
P
G
W
F
R
E
W
R
R
S
L
S-----
23
HHSearch
41.30
27%
-4
- C4 -
1J26
-
ICT1_MOUSE
A:
[13-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
---------
S
Y
I
P
L
D
R
L
S
I
S
---
Y
C
R
S
S
--
G
-
P
G
G
Q
N
V
N
K
V
N
S
K
A
-
E
V
R
F
HLASADWIE
E
P
V
R
Q
K
I
A
L
T
---------------------
H
------
K
NKINK
A
-----------------
G
---
E
-
L
V
L
T
S
E
S
S
R
Y
Q
F
-
R
N
L
A
E
C
-
L
Q
K
I
-
R
D
M
--
I
----
A
E
A
S
-
G
P
S
S
----
G
----------------------------------------------------------------------------------------------