@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0570: (2015-12-02 )
MFCFIDIACYNRLTMTQKKLRKYAVVDLEATGAGPNASIIQVGIVIIQGNKIIDSYETDVNPHESLDEHIVHLTGITDKQLAKAPDFGQVAHHIYQLIEDCIFVAHNVKFDANLLAEQLFLEGCELRTPRIDTVELSQVFYPCLEKYSLGALAESLNIELTDAHTAIADARATAQLFIKLKAKISSLPKEVLETILTFADNLLFESYLLIEEAYQEADFVNPKEYYFWQGLVLKKEKAVGKPKKLSSDFQVNMALLGMDARPKQVVFADLVKAHFNDQTTTFLEAQPGLGKTYGYLLPLLDQSQKQQIIVSVPTKILQDQIMAKEIKHIQELFHIPCHSIKGPRNYLKLDAFYKSLQVQDRNRLINRFKMQLLVWLTETTTGDLDEIKQKQRLESYFDQLKHDGEVTQSSLFYDLDFWKRSYDKVAQSQLVIINHAYFLERVQDDKDFAKGKVLVFDEAQKLVLGLENFSRGQLDISHQLQVIQKIIDSSIPLLQKRLLESISYELSHAVELFYRHNSFEFSETWLKRLKNSINALEVVGLDELQTFFTATYTNYWFETDKVNEKRLTILRGAREDFLKFSKFLPPTKKTYMISATLQISPKVYLSDLLGGFSSISTEKIAHEKNANQKVWIDTSMPNILDLSPEQYAYEIAKRLQDIMTLKQPTLVLLTSKQTMFMVSDYLDKWEIKHLTQDKNGLAYNVKKRFDRGESNLLLGTGSFWEGVDFVHRDRLIEVITRLPFDTPKDYFIQKLSQSLTKEGKNFFYDYSLPMTVLKLKQALGRTTRREEQKSAVIILDSRLVIKSYGQTIMHSLGRDFEISKEKINKVLTEMAKFLI
Atome Classification :
(20 SA)
.........10........20........30.---..---.------..------.------.40.......-------------------.50..----......60.--..--.....70........80----..--..-.....90..-......-----100--.-------..-------....-.-.110.-......120---.-----.---.-----.-----...130-----.........140---..-.-.....150...--....-160.--.--.---......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.--......310.......320.......330.......340...----....350.......360.......370.......380.......390.......400.......410.......420.......430.......440...----.-..--.450.------......460.----------......470.....--..480.......-490.......500.......510....------...-520.......530.-..-----....540.......550.......560......--------.570.......-580.......590.....---------..600.......610---.......620..-.---.------...630.......640........650......-.-660.......670.......680....--...690...-....700.......710.-.-..---...720.......---730.......740..-------.....750.....--..760.......770.......780.......790.......800.......810.......--820.......830...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
C
F
I
D
I
A
C
YN
R
L
T
M
T
Q
K
K
L
R
K
Y
A
V
V
D
L
EATG---AG---P------N
A
------
S
------
I
I
Q
V
G
I
V
I
I
Q-------------------G
N
K
I
I
----DSYETDVNP--
H
E
--
S
L
D
E
H
I
V
HLTGI
T
D
K
Q
-----LA--KA-P
D
F
G
Q
V
A
H
H
-
I
Y
Q
L
I
E
-----
D
----
C
-------
I
F
-------
V
AHN-V-KF
D
A
N
-
L
L
A
E
Q
L
F
LE---G-----C---E-----L-----RTPR-------I
D
T
V
E
L
S
Q
V
F
Y
----
P
C
-
L
-
E
KY
S
L
G
A
L
A
E
S--L
N
I
E
-
L
--T--D--A---
H
T
A
I
A
D
A
R
A
T
A
Q
L
F
I
K
L
K
A
K
I
S
S
L
P
K
E
V
L
E
T
I
L
T
F
A
D
N
L
L
F
E
S
Y
L
L
I
E
E
A
Y
Q
EADFVNP
K
E
Y
Y
F
WQ
G
L
V
L
K
K
E
KAVGKPKKLSSD
F
Q
V
N
M
A
L
LGMDARP
K
Q
V
V
F
A
D
L
V
K
A
HFNDQ
T
T
T
F
L
EAQPGLG
K
T
Y
G
Y
L
L
PLLDQS--QK
Q
Q
I
I
V
SV
P
T
K
I
L
Q
D
Q
I
M
A
K
E
I
K
H
I
Q
E
L
F
HIPCHSIKG
P
R
N
----
Y
L
K
L
D
A
F
Y
K
S
LQVQ
D
R
N
R
L
I
N
R
F
K
M
Q
L
L
V
W
L
TETTTG
D
L
D
E
I
K
Q
K
Q
R
L
E
S
Y
F
D
Q
L
KHDGEVT
Q
S
S
L
F
Y
D
L
D
F
W
K
R
S
Y
D
K
VAQS
Q
L
V
I
I
N
H
A
Y
F
L
E
R
VQDD----
K
-
D
F--AKG
K
V
------
L
V
FD
E
A
Q
K
L
V
----------
L
G
L
E
NFSRGQL
D
I
S
--
H
Q
L
Q
V
I
Q
K
I
I
DS-S
I
P
L
L
Q
K
R
L
L
E
S
I
S
Y
E
L
S
H
A
V
E
L
F
Y
RH------NSF-
E
F
S
E
T
W
L
K
R
L
K
NSI-N
A
-----
L
E
V
V
G
L
D
E
L
Q
T
F
F
T
A
T
Y
T
N
Y
W
F
ETDKVNE
K
R
L
T
--------
I
L
RG
A
R
E
D
F
L
K
-
F
S
K
FLPPTK
K
T
Y
M
I
S
A
T
L
---------
Q
IS
P
K
V
Y
L
S
D
L
LG
G
F
---
S
SI
S
T
E
K
IAHEK-N---A------N
Q
K
V
W
I
DTSMP
N
I
LD-L
S
P
E
Q
Y
A
Y
E
I
A
K
R
L
Q
D
I
-
M
-TLKQ
P
T
L
V
L
L
TSK
Q
T
M
F
M
V
S
D
Y
L
D
K
W
E
--
I
K
H
LTQDKN-G
L
A
Y
N
V
K
K
R
FDRGES
N
L
L
-
L
-GT---GSFWE
G
V
D
F
V
H
R
D
---
R
L
I
E
V
I
T
RLPFDT
P
K
-------
D
Y
F
I
Q
K
L
S
Q
S
L
T
K
--EGK
N
F
F
Y
DYSL
P
M
T
V
L
K
L
K
Q
A
LGRT
T
R
R
E
EQK
S
A
V
I
I
LDS
R
L
V
I
K
S
Y
G
Q
T
I
M
H
SLGRDFEI
S
--
K
E
K
I
N
K
V
L
T
E
M
A
K
F
LI
2
PsiBlast_PDB
80.71
21%
-41
* C1 *
4A15
6
XPD_THEAC
A:
[5-584]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Y
Q
V
E
A
I
D
F
L
R
S
S
L
Q
K
S
Y
G
V
A
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
S
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
-
K
E
L
R
S
L
S
S
T
M
K
I
R
A
I
P
M
Q
G
R
V
N
MCIL
Y
R
M
V
D
D
L
H
E
-
I
N
A
E
S
L
A
K
F
C
N
M
K
K
R
E
V
M
A
G
N
E
A
A
C
P
Y
F
N
F
K
I
R
S
D
E
T
K
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
R
S
V
A
E
----
K
-
F
L
--
S
H
W
G
V
SRNQ
I
V
I
I
L
D
E
A
H
N
L
P
D
I
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
E
L
S
Q
K
I
H
V
S
-
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
G
D
V
R
I
R
F
------
Q
E
F
M
E
Y
M
R
I
M
N
K
R
S
E
R
E
I
-
R
S
-----
L
----
L
N
Y
L
Y
L
F
--
G
E
Y
V
E
N
--
E
K
E
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
I
I
A
F
S
D
Q
D
E
E
K
-
Y
A
A
I
L
S
P
E
D
G
G
Y
M
Q
A
A
C
L
DPSGIL
E
V
L
K
E
S
K
T
I
H
M
S
G
T
L
D
P
F
D
F
Y
S
D
I
T
G
F
E
I
P
F
K
K
-
I
---
G
EIFPPE
N
R
Y
I
A
Y
Y
D
G
V
--------
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
-
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
--
M
K
E
Y
R
G
I
D
Q
-
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
A
V
-
S
G
---
G
R
L
--------
N
E
---
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
A
I
N
R
S
L
F
D
Y
Y
E
R
K
Y
---------
G
K
G
W
E
Y
S
V
V
Y
P
-
T
A
I
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
A
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
D
P
A
S
D
I
--
Y
N
F
F
I
S
A
Q
A
R
------
3
PsiBlast_PDB
74.66
21%
-40
- C1 -
2VSF
2
XPD_THEAC
A:
[9-566]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
SE
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
-
K
E
L
R
S
L
S
S
T
M
K
I
R
A
I
P
M
Q
G
R
V
N
MC
I
L
Y
R
M
V
D
D
L
H
E
-
I
N
A
E
S
L
A
K
F
C
N
M
K
K
R
E
V
M
A
G
N
E
A
A
C
P
Y
F
N
F
K
I
R
S
D
E
T
K
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
R
S
V
A
E
----
K
-
F
L
--
S
H
W
G
V
SRNQ
I
V
I
I
L
D
E
A
H
N
L
P
D
I
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
E
L
S
Q
K
I
H
V
S
-
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
G
D
V
R
I
R
F
------
Q
E
F
M
E
Y
M
R
I
M
N
K
R
S
E
R
E
I
-
R
S
-----
L
----
L
N
Y
L
Y
L
F
--
G
E
Y
V
E
N
--
E
K
E
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
I
I
A
F
S
D
Q
D
E
E
K
-
Y
A
A
I
L
S
P
E
D
G
G
Y
M
Q
A
A
C
L
DPSGILEVL
K
E
S
K
T
I
H
M
S
G
T
L
D
P
F
D
F
Y
S
D
I
T
G
F
E
I
P
F
K
K
-
I
---
G
EIFPPE
N
R
Y
I
A
Y
Y
D
G
V
S
S
K
Y
D
-
T
L
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
-
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
--
M
K
E
Y
R
G
I
D
Q
-
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
A
V
-
S
G
---
G
R
L
S
E
-----
G
N
E
---
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
A
I
N
R
S
L
F
D
Y
Y
E
R
K
Y
---------
G
K
G
W
E
Y
S
V
V
Y
P
-
T
A
I
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
A
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
D
P
A
S
D
I
--
Y
N
F
F
I
S
A
Q
A
R
------
21
HHSearch
73.89
18%
-50
- C1 -
3CRV
10
XPD_SULAC
A:
[2-548]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
R
D
W
Q
E
K
L
K
D
K
V
I
E
G
L
R
N
N
F
L
V
A
L
N
A
P
T
G
S
G
K
T
L
F
S
L
L
V
S
L
E
V
----
K
P
K
V
L
F
V
V
R
T
H
N
E
F
Y
P
I
Y
R
-
D
L
T
K
I
R
E
K
R
N
I
T
F
S
F
L
V
G
K
P
S
----
S
C
L
Y
A
E
K
G
A
E
S
------
E
D
---
I
P
C
K
Y
C
E
L
K
G
S
I
--
V
E
V
K
T
------
D
D
S
P
L
S
L
V
K
K
L
K
---
K
D
G
L
Q
D
K
F
C
P
Y
Y
S
L
L
N
S
L
Y
K
A
D
V
I
A
L
T
Y
P
Y
F
F
I
D
R
Y
R
E
----
F
I
D
I
D-
L
R
E
Y
M
------
I
V
I
D
E
A
H
N
L
D
----------
K
V
-
N
E
L
E
E
R
S
L
S
E
I
--
T
I
Q
M
A
I
K
Q
S
K
S
E
E
S
R
R
I
L
S
K
-
L
L
N
Q
L
R
E
V
V
L
P
D
-
E
K
Y
I
K
V
EN
V
P
K
L
S
K
E
-
E
L
E
-
I
L
A
D
D
Y
E
D
I
R
K
D
S
L
K
Q
GK
V
N
K
I
H
I
G
S
I
L
R
F
F
S
L
L
S
I
G
S
F
I
P
F
S
Y
-----
S
K
--------
R
L
V
I
K
N
P
E
I
S
Y
Y
L
N
L
L
N
D
N
E
L
S
I
I
L
M
S
G
T
L
---------
P
P
--
R
E
Y
M
E
K
V
W
G
I
K
---
R
N
M
L
Y
L
D
V
E
R
E
I
Q
K
RV
S
G
------
S
Y
E
C
Y
I
G
V
D
V
T
S
K
Y
D
M
R
S
-
D
N
M
W
K
R
Y
A
D
Y
L
L
K
I
-
Y
F
Q
A
K
A
N
V
L
V
V
F
P
S
Y
E
I
M
D
R
V
M
S
R
I
S
L
-----
P
K
Y
V
E
S
E
D
-
S
S
V
E
D
L
Y
S
A
I
S
A
N
-
N
K
V
L
-
I
-
G
S
V
GK
G
K
L
A
E
G
I
E
L
R
N
N
D
RSL
I
S
D
V
V
I
V
G
I
P
Y
P
P
P
D
-------
D
Y
L
K
-
I
L
A
Q
R
V
S
L
KM
N
R
E
N
E
E
F
L
F
K
I
P
-
A
L
V
T
I
K
Q
A
I
G
R
A
I
R
D
V
N
D
K
C
N
V
W
L
L
D
K
R
F
E
S
-
L
Y
W
K
K
N
L
K
C
L
N
A
N
K
M
K
L
------------------
24
HHSearch
67.82
23%
-77
- C2 -
2GUI
7
DPO3E_ECOLI
A:
[8-183]
-------------------
I
T
R
Q
I
V
L
D
T
E
T
T
G
---
M
N
---
Q
IGAHYE
G
H
------
K
------
I
I
E
I
G
A
V
E
V
V
-------------------
N
R
R
L
T
G---
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
K
-
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
-----
G
----
A
-------
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
---
K
-----
R
---
D
IPK
T
N
T
-----
F
C
K
V
-------
T
D
S
L
A
V
A
R
K
M
F
----
P
G
---
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
KR
T
--
L
---
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.48
34%
-86
- C2 -
2P1J
-
DPO3_THEMA
A:
[358-516]
----------------------
F
V
V
L
D
F
E
T
T
G
---
L
D
---
P
------
Q
V
------
D
E
-----
I
I
E
I
G
A
V
K
I
Q
-------------------
G
G
Q
I
V
----
D
E
Y
H
T
L
I
K
P
--
S
R
--
E
I
S
R
K
S
S
E
I
T
G
I
T
Q
E
M
-----
L
E
--
N
K
-
R
S
I
E
E
V
L
P
E
-
F
L
G
F
L
E
-----
D
----
S
-------
I
I
-------
V
A
H
N
-
A
-
N
F
D
Y
R
-
F
L
--
R
L
W
I
K
K
VM
G
-----
L
---
D
-----
W
-----
E
R
P
Y
-------
I
D
T
L
A
L
A
K
S
L
L
-----
K
-
L
-
R
S
Y
S
L
D
S
V
V
E
K
--
L
G
L
G
-
P
--
F
--
R
--
H
---
H
R
A
L
D
D
A
R
V
T
A
Q
V
F
L
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.97
22%
-83
- C2 -
1J53
6
DPO3E_ECOLI
A:
[10-180]
------------------------
V
L
D
T
E
T
T
G
---
M
N
---
Q
------
I
G
------
A
HYEGHK
I
I
E
I
G
A
V
E
V
V
-------------------
N
R
R
L
T
G---
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
K
-
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
-----
G
----
A
-------
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
----------
L
---
K
-----
R
-----
D
I
P
K
TNTF
C
K
V
T
D
S
L
A
V
A
R
K
M
F
----
P
G
---
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
--
K
--
R
TL-
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
66.09
24%
-76
- C2 -
1J54
6
DPO3E_ECOLI
A:
[7-180]
---------------------
R
Q
I
V
L
D
T
E
T
T
G
---
M
N
---
Q
------
I
G
AHYEGH
K
------
I
I
E
I
G
A
V
E
V
V
-------------------
N
-
R
R
L
TGN
N
F
H
V
Y
L
K
P
----
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
-K
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
------G---
A
-------
E
L
-------
V
I
H
N
A
--
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
---
K
-----
R
---
D
-----
I
PKTNT
F
C
K
V
-------
T
D
S
L
A
V
A
R
K
M
F
----
P
---G
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
--
K
--
R
TL-
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.84
22%
-85
- C2 -
2GUI
7
DPO3E_ECOLI
A:
[13-183]
------------------------
V
L
D
T
E
T
T
G
---
M
N
---
Q
------
I
G
------
A
HYEGHK
I
I
E
I
G
A
V
E
V
V
-------------------
N
R
R
L
T
G---
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
K
-
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
-----
G
----
A
-------
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
----------
L
---
K
-----
R
-----
D
I
P
K
T
N
T
F
C
KV
T
D
S
L
A
V
A
R
K
M
F
----
P
G
---
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
--
K
--
R
TL-
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.83
22%
-83
- C2 -
1J54
6
DPO3E_ECOLI
A:
[10-180]
------------------------
V
L
D
T
E
T
T
G
---
M
N
---
Q
------
I
G
------
A
HYEGHK
I
I
E
I
G
A
V
E
V
V
-------------------
N
R
R
L
T
G---
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
K
-
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
-----
G
----
A
-------
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
----------
L
---
K
-----
R
-----
D
I
P
K
TNTF
C
K
V
T
D
S
L
A
V
A
R
K
M
F
----
P
G
---
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
--
K
--
R
TL-
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
65.47
23%
-78
* C2 *
1J54
6
DPO3E_ECOLI
A:
[7-180]
---------------------
R
Q
I
V
L
D
T
E
T
T
G
---
M
N
---
Q
------
I
G
AHYEGH
K
------
I
I
E
I
G
A
V
E
V
V
-------------------
N
R
R
L
T
G---
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
L
--
D
K
-
P
T
F
A
E
V
A
D
E
-
F
M
D
Y
I
R
-----
G
----
A
-------
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
---
K
RDIPK
T
---
N
-----
T
-----
F
C
K
V
-------
T
D
S
L
A
V
A
R
K
M
F
----
P
--
G
-
K
R
N
S
L
D
A
L
C
A
R
--
Y
E
I
D
-
N
--
S
--
K
RT
L
---
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.62
32%
-70
- C2 -
2P1J
-
DPO3_THEMA
A:
[357-520]
---------------------
T
F
V
V
L
D
F
E
T
T
G
---
L
D
---
P
Q-----
V
D
------
E
------
I
I
E
I
G
A
V
K
I
Q
-------------------
G
G
Q
I
V
----
D
E
Y
H
T
L
I
K
P
--
S
R
--
E
I
S
R
K
S
S
E
I
T
G
I
T
Q
E
M
-----
L
E
--
N
K
-
R
S
I
E
E
V
L
P
E
-
F
L
G
F
L
E
-----
D
----
S
-------
I
I
-------
V
A
H
N
-
A
-
N
F
D
Y
R
-
F
L
R
L
W
I
K
K
V
---
M
-----
G
L--
D
-----
W
-----
E
R
P
Y
-------
I
D
T
L
A
L
A
K
S
L
L
----
K
--
L
-
R
S
Y
S
L
D
S
V
V
E
K
--
L
G
L
G
-
P
--
F
--
R
--
H
---
H
R
A
L
D
D
A
R
V
T
A
Q
V
F
L
R
F
V
E
M
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
63.60
21%
-56
- C2 -
3MXM
7
TREX1_MOUSE
B:
[9-217]
-----------------
G
H
M
Q
T
L
I
F
L
D
L
E
A
T
G
---
L
P
---
S
S-----
R
P
------
E
------
V
T
E
L
C
L
L
A
V
H
R
R
A
L
E
N
TSISQGHPPPVPR
P
P
R
V
V
----
D
K
L
S
L
C
I
A
P
--
G
K
--
A
C
S
P
G
A
S
E
I
T
G
L
S
K
A
E
-----
L
E
V
Q
G
R
-
Q
R
F
D
D
N
L
A
I
L
L
R
A
F
L
Q
-----
R
QPQP
C
-------
C
L
-------
V
A
H
N
-
G
D
R
Y
D
F
P
-
L
L
Q
T
E
L
A
R
L
---
S
-----
T
---
P
-----
S
PLD--
G
T
F
C
-------
V
D
S
I
A
A
L
K
A
L
E
Q
A
S
S
P
----
K
S
Y
S
L
G
S
I
Y
T
R
--
L
Y
W
Q
A
P
--
T
--
D
--
S
---
H
T
A
E
G
D
D
L
T
L
L
S
I
C
Q
W
K
P
Q
A
L
L
Q
W
V
D
E
H
A
R
P
F
S
T
V
K
P
M
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
63.29
14%
-51
- C1 -
2V1X
4
RECQ1_HUMAN
A:
[36-372]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
----
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
----
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
-
V
L
K
Q
----
L
G
I
S
A
T
M
L
N
A
S
S
S
----
K
-----------------
E
H
V
-------
K
W
V
-----------------------------------------
H
A
E
M
V
N
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
K
M
F
M
S
R
L
E
K
-
A
Y
E
A
R
R
F
T
R
------
I
A
V
D
E
V
H
C
C
S
----------
Q
W
G
H
D
F
R
P
D
Y
------------
K
A
L
-------------
G
---------------------------------------------------------------------
I
--------------------------------
L
K
R
Q
F
P
-
N
A
S
L
I
G
L
T
A
T
A
---------
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
---
K
C
---
F
T
F
T
A
S
F
N
R
---
P
------
N
L
Y
Y
E
V
R
Q
K
P
S
-
N
-----
T
E
D
F
I
E
D
I
V
K
L
I
N
G
R
---
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
IH
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
-
V
-
A
T
---
V
A
F
G
M
G
I
D
K
P
D
-----
V
R
F
V
I
H
H
S
M
S
K
S
M
---------------------------------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
G
Q
Q
K
L
Y
E
--
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
M
11
PsiBlast_PDB
60.51
26%
-69
- C2 -
4FZX
4
EXOX_ECOLI
C:
[4-150]
------------------------
I
I
D
T
E
T
C
G
---
L
-----------
Q
G
------
G
------
I
V
E
I
A
S
V
D
V
I
-------------------
D
G
K
I
V
----
N
P
M
S
H
L
V
R
P
--
D
R
--
P
I
S
P
Q
A
M
A
I
H
R
I
T
E
A
M
-----
V
A
--
D
K
-
P
W
I
E
D
V
I
P
H
-
Y
Y
G
--------
S
----
E
-------
W
Y
-------
V
A
H
N
-
A
-
S
F
D
R
R
-
V
L
P
E
M
P
G
E
W
---
I
-----
C
----------------------------
T
M
K
L
A
R
R
L
W
----
P
G
-
I
--
K
Y
S
N
M
A
L
Y
K
T
RK
L
N
V
Q
-
T
--
P
--
P
--
G
LHH
H
R
A
L
Y
D
C
Y
I
T
A
A
L
L
I
D
I
M
N
T
S
G
W
T
A
E
Q
M
A
D
I
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.34
26%
-67
- C2 -
4FZY
4
EXOX_ECOLI
A:
[4-150]
------------------------
I
I
D
T
E
T
C
G
---
L
-----------
Q
G
------
G
------
I
V
E
I
A
S
V
D
V
I
-------------------
D
G
K
I
V
----
N
P
M
S
H
L
V
R
P
--
D
R
--
P
I
S
P
Q
A
M
A
I
H
R
I
T
E
A
M
-----
V
A
--
D
K
-
P
W
I
E
D
V
I
P
H
-
Y
Y
G
--------
S
----
E
-------
W
Y
-------
V
A
H
N
-
A
-
S
F
D
R
R
-
V
L
P
-------------------
E
-----
M
-----
P
G
E
W
-------
I
C
T
M
K
L
A
R
R
L
W
----
P
G
-
I
--
K
Y
S
N
M
A
L
Y
K
T
R
K
L
N
V
Q
-
T
--
P
--
P
--
G
LHH
H
R
A
L
Y
D
C
Y
I
T
A
A
L
L
I
D
I
M
N
T
S
G
W
T
A
E
Q
M
A
D
I
T
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
60.25
22%
-63
- C2 -
1ZBU
3
ERI1_HUMAN
A:
[125-315]
-----------------
S
Y
Y
D
Y
I
C
I
I
D
F
E
A
T
C
---
E
E
GNP
P
E
F
----
V
H
------
E
------
I
I
E
F
P
V
V
L
L
N
TH-----------------
T
L
E
I
E
----
D
T
F
Q
Q
Y
V
R
P
--
E
I
NT
Q
L
S
D
F
C
I
S
L
T
G
I
T
Q
D
Q
-----
V
D
--
R
A
-
D
T
F
P
Q
V
L
K
K
-
V
I
D
L
M
K
-----
L
----
K
ELGTK
Y
K
Y
S
-------
L
L
T
D
-
G
-
S
W
D
M
S
K
F
L
N
I
Q
C
Q
L
S
---
R
-----
L
---
K
YPP--
F
-----
A
K
K
W
-------
I
N
I
R
K
S
Y
G
N
F
Y
----
K
V
P
R
-
S
Q
T
K
L
T
I
M
L
E
K
--
L
G
M
D
-
Y
D
-
G
--
R
--
P
---
H
C
G
L
D
D
S
K
N
I
A
R
I
A
V
R
M
L
Q
D
G
C
E
L
R
I
N
E
K
M
H
A
G
Q
L
M
S
V
S
S
S
L
P
I
E
G
T
P
P
P
Q
M
P
H
F
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
59.79
20%
-56
- C2 -
2F96
1
RNT_PSEAE
A:
[25-217]
----------------
R
F
R
G
Y
L
P
V
V
V
D
V
E
T
G
G
---
F
N
---
S
A-----
T
D
------
A
------
L
L
E
I
A
A
T
T
V
G
M
D
E----------------
K
G
F
L
F
P
E
--
H
T
Y
F
F
R
I
E
P
FE
G
A
--
N
I
E
P
A
A
L
E
F
T
G
I
K
L
D
H
PLRMA
V
Q
--
E
E
-
A
A
L
T
E
I
F
R
G
-
I
R
K
A
L
K
A
N
GCK
R
----
A
-------
I
L
-------
V
G
H
N
-
S
-
S
F
D
L
G
-
F
L
N
A
A
V
A
R
T
---
G
-----
I
---
K
RNPF-
H
-----
P
F
S
S
-------
F
D
T
A
T
L
A
G
L
A
Y
----
G
-----
Q
T
V
L
A
K
A
C
Q
A
--
A
G
M
E
-
F
D
N
R
--
E
--
A
---
H
S
A
R
Y
D
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
M
G
G
W
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
59.77
12%
-44
- C1 -
2VSF
2
XPD_THEAC
A:
[5-597]
----------------------
Y
G
V
A
L
E
S
P
T
G
---
S
G
---
K
------
T
I
------
M
------
A
L
K
S
A
L
---------------------------------------
Q
Y
--
S
S
--
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
-----
E
Q
--
V
I
-
K
E
L
R
S
L
S
S
T
-
M
--------------------------------------------------------------------------------------------------------------------------------------
K
--
I
---
R
A
I
P
M
Q
G
R
V
N
M
C
I
L
Y
R
M
V
D
D
L
H
E
I
N
A
E
S
L
A
K
F
C
N
M
K
K
R
E
V
M
A
G
N
-------------------
E
A
A
C
P
Y
F
N
F
K
I
R
S
D
E
T
K
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
----------------------------
P
Y
E
S
M
K
A
A
L
--
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
R
S
V
A
E
K
F
L
S
H
W
G
---------
V
S
R
N
Q
I
----
V
I
I
L
D
E
A
H
N
L
P
D
I
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
E
L
S
Q
K
I
H
V
S
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
------------------------------------------------------------------------------
G
D
V
R
I
R
F
Q
--
E
F
M
E
Y
M
R
I
M
N
K
R
------
S
E
R
E
I
R
S
L
L
N
Y
L
Y
L
F
G
E
Y
V
E
N
E
------
K
E
K
-
V
G
K
V
P
F
----------
S
-----
Y
C
S
S
V
A
S
R
I
I
A
F
S
D
Q
D
E
E
K
Y
A
A
I
L
S
P
E
D
G
G
Y
M
Q
--------
A
A
C
------
L
D
-
P
S
G
I
L
E
V
L
K
E
S
K
T
I
H
M
S
G
---------
T
L
D
P
F
D
F
Y
S
D
I
T
G
F
E
---
I
P
F
K
K
I
G
E
I
F
P
P
-
E
---
N
------
R
Y
I
A
Y
Y
D
G
V
S
S
K
Y
D
T
-
L
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
-
L
-
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
--
M
K
E
Y
R
G
I
D
Q
-
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
-
A
V
S
G
---
G
R
L
S
E
G
N
E
L
E
--------
M
I
I
L
A
G
L
P
F
P
R
P
--------
D
A
I
N
R
S
L
F
D
Y
Y
E
R
--
K
Y
G
K
G
W
E
Y
S
V
V
Y
P
T
A
I
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
A
------
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
D
P
A
S
D
I
Y
N
F
F
I
S
A
Q
A
R
--
30
HHSearch
59.35
22%
-68
- C2 -
1W0H
3
ERI1_HUMAN
A:
[5-198]
---------------
A
D
S
Y
Y
D
Y
I
C
I
I
D
F
E
A
T
C
E
EG
N
P
---
P
E
F
----
V
H
------
E
------
I
I
E
F
P
V
V
L
L
N
TH-----------------
T
L
E
I
E
----
D
T
F
Q
Q
Y
V
R
P
--
E
I
NT
Q
L
S
D
F
C
I
S
L
T
G
I
T
Q
D
Q
-----
V
D
--
R
A
-
D
T
F
P
Q
V
L
K
K
-
V
I
D
W
M
K
-----
L
----
K
-------
E
L
GTK
Y
K
Y
S
L
L
T
D
-
G
-
S
W
D
M
S
K
F
L
N
I
Q
C
Q
L
S
---
R
-----
L
KYP
P
-----
F
-----
A
K
K
W
-------
I
N
I
R
K
S
Y
G
N
F
Y
----
K
V
P
R
-
S
Q
T
K
L
T
I
M
L
E
K
--
L
G
M
D
-
Y
D-
G
--
R
--
P
---
H
C
G
L
D
D
S
K
N
I
A
R
I
A
V
R
M
L
Q
D
G
C
E
L
R
I
N
E
K
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.35
26%
-67
- C2 -
4FZZ
4
EXOX_ECOLI
A:
[4-150]
------------------------
I
I
D
T
E
T
C
G
---
L
-----------
Q
G
------
G
------
I
V
E
I
A
S
V
D
V
I
-------------------
D
G
K
I
V
----
N
P
M
S
H
L
V
R
P
--
D
R
--
P
I
S
P
Q
A
M
A
I
H
R
I
T
E
A
M
-----
V
A
--
D
K
-
P
W
I
E
D
V
I
P
H
-
Y
Y
G
--------
S
----
E
-------
W
Y
-------
V
A
H
N
-
A
-
S
F
D
R
R
-
V
L
P
-------------------
E
-----
M
-----
P
G
E
W
-------
I
C
T
M
K
L
A
R
R
L
W
----
P
G
-
I
--
K
Y
S
N
M
A
L
Y
K
T
R
K
L
N
V
Q
-
T
--
P
--
P
--
G
LHH
H
R
A
L
Y
D
C
Y
I
T
A
A
L
L
I
D
I
M
N
T
S
G
W
T
A
E
Q
M
A
D
I
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------