@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0580: (2015-12-02 )
MRKKFLLLMSFVAMFAAWQLVQVKQVWADSKLKVVTTFYPVYEFTKNVVGDKADVSMLIKAGTEPHDFEPSTKNIAAIQDSNAFVYMDDNMETWAPKVAKSVKSKKVTTIKGTGDMLLTKGVEEEGEEHEGHGHEGHHHELDPHVWLSPERAISVVENIRNKFVKAYPKDAASFNKNADAYIAKLKELDKEYKNGLSNAKQKSFVTQHAAFGYMALDYGLNQVPIAGLTPDAEPSSKRLGELAKYIKKYNINYIYFEENASNKVAKTLADEVGVKTAVLSPLEGLSKKEMAAGEDYFSVMRRNLKVLKKTTDVAGKEVAPEEDKTKTVETGYFKTKDVKDRKLTDYSGNWQSVYPLLQDGTLDPVWDYKAKSKKDMTAAEYKKYYTAGYKTDVESIKIDGKKHQMTFVRNGKSQTFTYKYAGYKILTYKKGNRGVRYLFEAKEKDAGQFKYIQFSDHGIKPNKAEHFHIFWGSESQEKLFEEMENWPTYFPAKMSGREVAQDLMSH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.-.---....----..100.......-----------110........120.........130.......140.......150.......160.......170.......180.......190......--.--200.......210.......220.......230.......240.......250.......260.......270---...--..---..280---.--....----...290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
K
K
F
L
L
L
M
S
F
V
A
M
F
A
A
W
Q
L
V
Q
V
K
Q
VWADSK
L
K
V
V
T
T
F
Y
P
V
Y
E
F
T
K
N
VVGDK
A
D
V
S
M
L
IKAGTEPHDFEPSTK
N
I
A
A
IQDS
N
A
F
V
Y
MDDN
M
E
-
T
---
W
A
P
K
----
V
A
K
S
VKSK
K
V
T
T
-----------I-KGTG
D
M
L
L
TK--GVEEEGEEHEGHGHEGHHHELDP
H
V
WL
S
P
E
R
A
I
S
V
V
E
N
I
R
N
K
F
V
K
AYPK
D
A
ASFNK
N
A
D
A
Y
I
A
K
L
K
E
L
D
K
E
Y
K
NGLS
N
--
A
--
K
Q
K
S
F
V
T
Q
H
AA
F
G
Y
M
A
L
DYGLNQVPIAGLTPDAE
P
S
S
K
R
L
G
E
L
A
K
Y
I
K
KYN
I
N
Y
I
Y
FEENAS
N
K
V
A
K
T
L
A
D
E
V---GV
K
--
T
A
---
V
L
S
P
----
L
--EGL
S
----
K
K
E
MAA
G
E
D
Y
F
S
V
M
R
R
N
L
K
V
L
K
K
TTDVAGKEVAPEEDKT
K
T
VETG
Y
F
KTKDVKDRKLTDYSG
N
W
Q
S
V
Y
P
L
LQDGTLDPVWDYKAKSKKD
M
T
A
A
E
Y
K
K
Y
YTAGYKTDV
E
S
I
K
IDGKK
H
Q
M
T
F
V
RNGKS
Q
T
F
T
Y
K
YA
G
Y
K
I
L
T
Y
KKGNRG
V
R
Y
L
F
EAKEKDAG
Q
F
K
Y
I
Q
FSDHGIKPNKA
E
H
F
H
I
F
WGSE
S
Q
E
K
L
F
E
E
M
ENWPTYFPAKMS
G
R
E
V
A
Q
D
L
MSH
1
PsiBlast_PDB
97.27
51%
-75
- C4 -
2O1E
1
ZNUA_BACSU
A:
[21-299]
------------------------------
K
L
H
V
V
T
T
F
Y
P
M
Y
E
F
T
K
Q
I
V
K
D
K
G
D
V
D
L
L
I
P
S
S
V
E
P
H
D
W
E
P
T
P
K
D
I
A
N
I
Q
D
A
D
L
F
V
Y
N
S
E
Y
M
E
-
T
---
W
V
P
S
----
A
E
K
S
M
G
Q
G
H
A
V
F
-----------
V
-
N
A
S
K
G
I
D
L
M
E
--
G
-----------------
H
A
M
D
P
H
V
W
L
S
P
V
L
A
Q
K
E
V
K
N
I
T
A
Q
I
V
K
Q
D
P
D
N
K
E
Y
Y
E
K
N
S
K
E
Y
I
A
K
L
Q
D
L
D
K
L
Y
R
T
T
A
K
K
--
A
--
E
K
K
E
F
I
T
Q
H
T
A
F
G
Y
L
A
K
E
Y
G
L
K
Q
V
P
I
A
G
L
S
P
D
Q
E
P
S
A
A
S
L
A
K
L
K
T
Y
A
K
E
H
N
V
K
V
I
Y
F
E
E
I
A
S
S
K
V
A
D
T
L
A
S
E
I
---
G
A
K
--
T
E
---
V
L
N
T
----
L
--
E
G
L
S
----
K
E
E
Q
D
K
G
L
G
Y
I
D
I
M
K
Q
N
L
D
A
L
K
D
S
L
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
96.82
49%
-73
- C4 -
2O1E
1
ZNUA_BACSU
A:
[21-302]
------------------------------
K
L
H
V
V
T
T
F
Y
P
M
Y
E
F
T
K
Q
I
V
K
D
K
G
D
V
D
L
L
I
P
S
S
V
E
P
H
D
W
E
P
T
P
K
D
I
A
N
I
Q
D
A
D
L
F
V
Y
N
S
E
Y
M
E
-
T
---
W
V
P
S
----
A
E
K
S
M
G
Q
G
H
A
V
F
-----------
V
-
N
A
S
K
G
I
D
L
M
E
--
G
-----------------
H
A
M
D
P
H
V
W
L
S
P
V
L
A
Q
K
E
V
K
N
I
T
A
Q
I
V
K
Q
D
P
D
N
K
E
Y
Y
E
K
N
S
K
E
Y
I
A
K
L
Q
D
L
D
K
L
Y
R
T
T
A
K
K
--
A
--
E
K
K
E
F
I
T
Q
H
T
A
F
G
Y
L
A
K
E
Y
G
L
K
Q
V
P
I
A
G
L
S
P
D
Q
E
P
S
A
A
S
L
A
K
L
K
T
Y
A
K
E
H
N
V
K
V
I
Y
F
E
E
I
A
S
S
K
V
A
D
T
L
A
S
E
I
---
G
A
K
--
T
E
---
V
L
N
T
----
L
--
E
G
L
S
----
K
E
E
Q
D
K
G
L
G
Y
I
D
I
M
K
Q
N
L
D
A
L
K
D
S
L
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.10
35%
-76
- C4 -
3GI1
1
?
B:
[13-281]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
-----
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
N
L
K
K
S
K
V
D
V
FEASKP
L
T
L
D
R
V
-------------------
L
-------------
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
R
L
D
P
K
H
K
D
S
Y
T
K
N
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.81
35%
-67
- C4 -
4H0F
1
?
B:
[2-259]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
N
L
K
K
S
K
V
N
V
-----------
F
-
E
A
S
K
P
L
T
L
D
R
---
V
K
P
G
A
T
V
Y
------------
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
87.73
36%
-57
- C4 -
3CX3
3
?
A:
[7-283]
---------------------------
T
G
K
G
M
K
I
V
T
S
F
Y
P
I
Y
A
M
V
K
E
V
S
G
D
L
N
D
V
R
-
M
I
Q
S
S
S
G
I
H
S
F
E
P
S
A
N
D
I
A
A
I
Y
D
A
D
V
F
V
Y
H
S
H
T
L
E
-
S
---
W
A
G
S
----
L
D
P
N
L
K
K
S
K
V
K
V
-----------
L
-
E
A
S
E
G
M
T
L
E
R
--
V
P
G
---------------
T
L
Y
D
P
H
T
W
L
D
P
E
K
A
G
E
E
A
Q
I
I
A
D
K
L
S
E
V
D
S
E
H
K
E
T
Y
Q
K
N
A
Q
A
F
I
K
K
A
Q
E
L
T
K
K
F
Q
P
K
F
E
K
--
A
--
T
Q
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
N
Q
L
G
I
A
G
I
S
P
E
Q
E
P
S
P
R
Q
L
T
E
I
Q
E
F
V
K
T
Y
K
V
K
T
I
F
T
E
S
N
A
S
S
K
V
A
E
T
L
V
K
S
T
---
G
V
G
--
L
K
---
T
L
N
P
----
L
--
E
S
D
P
--------
Q
N
D
K
T
Y
L
E
N
L
E
E
N
M
S
I
L
A
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
87.45
35%
-67
- C4 -
4H0F
1
?
A:
[2-259]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
N
L
K
K
S
K
V
N
V
-----------
F
-
E
A
S
K
P
L
T
L
D
R
---
V
K
P
G
A
T
V
Y
------------
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.01
35%
-80
- C4 -
3GI1
1
?
A:
[13-281]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
-----
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
N
L
K
K
S
K
V
D
V
F
EASKP
L
T
L
D
R
V
-
K
-----------------
L
-------------
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
R
L
D
P
K
H
K
D
S
Y
T
K
N
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
---
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.75
35%
-73
- C4 -
3HJT
1
?
B:
[14-282]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
---
K
S
K
V
N
V
F
EASKP
L
T
L
D
R
V
-
K
-----------------
L
-------------
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.56
35%
-72
- C4 -
3HJT
1
?
A:
[14-282]
-------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
-
A
---
W
A
R
D
----
L
D
P
---
K
S
K
V
N
V
F
EASKP
L
T
L
D
R
V
-
K
G
---------------
T
L
-------------
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
---
G
A
K
--
V
K
---
T
L
S
P
----
L
--
E
A
A
P
--------
S
G
N
K
T
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.61
24%
-70
- C4 -
1PQ4
1
?
A:
[2-289]
------------------------------
A
M
D
I
T
V
S
I
P
P
Q
Q
Y
F
L
E
K
I
G
G
D
L
V
R
V
S
V
L
V
P
G
N
N
D
P
H
T
Y
E
P
K
P
Q
Q
L
A
A
L
S
E
A
E
A
Y
V
L
I
G
L
G
F
E
Q
P
---
W
L
E
K
----
L
K
A
A
N
A
--
N
M
K
L
-----------
I
-
D
S
A
Q
G
I
T
P
L
E
--
M
E
K
---------------
M
V
A
D
P
H
I
W
L
S
P
T
L
V
K
R
Q
A
T
T
I
A
K
E
L
A
E
L
D
P
D
N
R
D
Q
Y
E
A
N
L
A
A
F
L
A
E
L
E
R
L
N
Q
E
L
G
Q
I
L
Q
P
--
L
--
P
Q
R
K
F
I
V
F
H
P
S
W
A
Y
F
A
R
D
Y
N
L
V
Q
I
P
I
E
--
V
E
G
Q
E
P
S
A
Q
E
L
K
Q
L
I
D
T
A
K
E
N
N
L
T
M
V
F
G
E
T
Q
F
S
T
K
S
S
E
A
I
A
A
E
I
---
G
A
G
--
V
E
---
L
L
D
P
----
L
--
A
--------------
A
D
W
S
S
N
L
K
A
V
A
Q
K
I
A
N
A
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
82.76
26%
-55
* C4 *
3UJP
8
?
A:
[28-301]
---------------------------
T
E
E
K
K
K
V
L
T
T
F
T
V
L
A
D
M
V
Q
N
V
A
G
D
K
L
V
V
E
S
I
T
R
I
G
A
E
I
H
G
Y
E
P
T
P
S
D
I
V
K
A
Q
D
A
D
L
I
L
Y
N
G
M
N
L
E
-
R
---
W
F
E
Q
----
F
L
G
N
V
K
D
--
V
P
S
-----------
V
-
V
L
T
E
G
I
E
P
I
P
--
I
A
-----------
D
G
P
Y
T
D
K
P
N
P
H
A
W
M
S
P
R
N
A
L
V
Y
V
E
N
I
R
Q
A
F
V
E
L
D
P
D
N
A
K
Y
Y
N
A
N
A
A
V
Y
S
E
Q
L
K
A
I
D
R
Q
L
G
A
D
L
E
Q
--
V
PA
N
Q
R
F
L
V
S
C
E
G
A
F
S
Y
L
A
R
D
Y
G
M
E
E
I
Y
M
W
P
I
N
A
E
Q
Q
F
T
P
K
Q
V
Q
T
V
I
E
E
V
K
T
N
N
V
P
T
I
F
C
E
S
T
V
S
D
K
G
Q
K
Q
V
A
Q
A
T
---
G
A
R
--
F
G
G
N
L
Y
V
D
S
----
L
--
S
T
E
E
--------
G
P
V
P
T
F
L
D
L
L
E
Y
D
A
R
V
I
T
N
G
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.62
27%
-64
- C4 -
4NNO
1
?
A:
[14-286]
------------------------------
K
L
K
V
V
T
T
N
S
I
L
Y
D
M
A
K
N
V
G
G
D
N
V
D
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
V
K
P
K
D
I
K
K
L
T
D
A
D
V
I
L
Y
N
G
L
N
L
E
-
T
GNG
W
F
E
K
A
L
E
Q
A
G
K
S
L
K
D
K
K
V
I
A
-----------
V
S
K
D
V
K
P
I
Y
L
---------------
N
G
E
E
G
N
K
D
K
Q
D
P
H
A
W
L
S
L
D
N
G
I
K
Y
V
K
T
I
Q
Q
T
F
I
D
N
D
K
K
H
K
A
D
Y
E
K
Q
G
N
K
Y
I
A
Q
L
E
K
L
N
N
D
S
K
D
K
F
N
D
--
I
PK
E
Q
R
A
M
I
T
S
E
G
A
F
K
Y
F
S
K
Q
Y
G
I
T
P
G
Y
I
W
E
I
N
T
E
K
Q
G
T
P
E
Q
M
R
Q
A
I
E
F
V
K
K
H
K
L
K
H
L
L
V
E
T
S
V
D
K
K
A
M
E
S
L
S
E
E
-----
T
K
--
K
D
---
I
F
G
E
----
V
--
Y
T
D
S
I---
G
K
E
G
T
K
G
D
S
Y
Y
K
M
M
K
S
N
I
E
T
V
H
G
S
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
82.28
27%
-66
- C4 -
4NNP
-
?
A:
[14-286]
------------------------------
K
L
K
V
V
T
T
N
S
I
L
Y
D
M
A
K
N
V
G
G
D
N
V
D
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
V
K
P
K
D
I
K
K
L
T
D
A
D
V
I
L
Y
N
G
L
N
L
E
-
T
GNG
W
F
E
K
A
L
E
Q
A
G
K
S
L
K
D
K
K
V
I
A
-----------
V
S
K
D
V
K
P
I
Y
L
---------------
N
-
E
E
G
N
K
D
K
Q
D
P
H
A
W
L
S
L
D
N
G
I
K
Y
V
K
T
I
Q
Q
T
F
I
D
N
D
K
K
H
K
A
D
Y
E
K
Q
G
N
K
Y
I
A
Q
L
E
K
L
N
N
D
S
K
D
K
F
N
D
--
I
PK
E
Q
R
A
M
I
T
S
E
G
A
F
K
Y
F
S
K
Q
Y
G
I
T
P
G
Y
I
W
E
I
N
T
E
K
Q
G
T
P
E
Q
M
R
Q
A
I
E
F
V
K
K
H
K
L
K
H
L
L
V
E
T
S
V
D
K
K
A
M
E
S
L
S
E
E
--------------
I
F
G
E
----
V
--
Y
T
D
S
I---
G
K
E
G
T
K
G
D
S
Y
Y
K
M
M
K
S
N
I
E
T
V
H
G
S
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
81.81
21%
-53
- C4 -
1TOA
2
TROA_TREPA
A:
[37-313]
-----------------------------
G
K
P
L
V
V
T
T
I
G
M
I
A
D
A
V
K
N
I
A
Q
G
D
V
H
L
K
G
L
M
G
P
G
V
D
P
H
L
Y
T
A
T
A
G
D
V
E
W
L
G
N
A
D
L
I
L
Y
N
G
L
H
L
E
-
T
---
K
M
G
E
----
V
F
S
K
L
R
G
S
R
L
V
V
-----------
A
--------
V
S
E
--
T
I
P
V
S
Q
R
L
S
L
E
E
A
------
E
F
D
P
H
V
W
F
D
V
K
L
W
S
Y
S
V
K
A
V
Y
E
S
L
C
K
L
L
P
G
K
T
R
E
F
T
Q
R
Y
Q
A
Y
Q
Q
Q
L
D
K
L
D
A
Y
V
R
R
K
A
Q
S
LP
A
--
E
R
R
V
L
V
T
A
H
D
A
F
G
Y
F
S
R
A
Y
G
F
E
V
K
G
L
Q
G
V
S
T
A
S
E
A
S
A
H
D
M
Q
E
L
A
A
F
I
A
Q
R
K
L
P
A
I
F
I
E
S
S
I
P
H
K
N
V
E
A
L
R
D
A
V
---
Q
A
R
--
G
H
---
V
V
Q
I
----
G
--
G
E
L
F
S
DAM
G
D
A
G
T
S
E
G
T
Y
V
G
M
V
T
H
N
I
D
T
I
V
A
A
L
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.65
39%
-55
- C4 -
3CX3
3
?
A:
[12-259]
--------------------------------
K
I
V
T
S
F
Y
P
I
Y
A
M
V
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
S
S
G
I
H
S
F
E
P
S
A
N
D
I
A
A
I
Y
D
A
D
V
F
V
Y
H
S
H
T
L
E
-
S
---
W
A
G
S
----
L
D
P
N
L
K
K
S
K
V
K
V
-----------
L
-
E
A
S
E
G
M
T
L
E
R
VP
G
--------------
T
L
Y
---
D
P
H
T
W
L
D
P
E
K
A
G
E
E
A
Q
I
I
A
D
K
L
S
E
V
D
S
E
H
K
E
T
Y
Q
K
N
A
Q
A
F
I
K
K
A
Q
E
L
T
K
K
F
Q
P
K
F
E
K
--
A
--
T
Q
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
N
Q
L
G
I
A
G
I
S
P
E
Q
E
P
S
P
R
Q
L
T
E
I
Q
E
F
V
K
T
Y
K
V
K
T
I
F
T
E
S
N
A
S
S
K
V
A
E
T
L
V
K
S
T
---
G
V
G
--
L
K
---
T
L
N
P
----
L
--
E
S
D
P
----
Q
N
D
K
T
Y
L
E
N
L
E
E
N
M
S
I
L
A
E
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
80.52
24%
-51
- C4 -
3MFQ
1
?
A:
[5-282]
-----------------------------
S
K
P
R
V
A
V
T
T
S
F
L
N
D
M
V
Y
Q
L
A
G
D
E
V
E
R
D
L
L
I
P
A
G
E
D
P
H
L
Y
V
A
K
S
S
D
L
S
K
L
Q
K
A
D
L
V
L
Y
H
G
L
H
F
E
-
G
---
K
M
V
E
----
A
L
E
K
T
G
---
V
A
V
-----------
S
-
K
N
---
F
N
A
K
D
--
L
N
T
M
---------
D
E
D
G
E
E
I
V
D
P
H
F
W
F
S
I
P
L
Y
K
S
A
V
A
V
A
S
E
E
L
Q
K
L
L
P
A
K
A
E
M
I
Q
K
N
T
E
K
Y
Q
A
Q
L
D
D
L
H
A
W
V
E
K
E
L
S
V
--
I
PK
E
S
R
Y
L
V
T
P
H
D
A
F
N
Y
F
A
A
S
Y
D
F
T
L
Y
A
P
Q
G
V
S
T
D
S
E
V
A
N
S
D
M
I
E
T
V
N
L
I
I
D
H
N
I
K
A
I
F
T
E
S
T
T
N
P
E
R
M
K
K
L
Q
E
A
V
K
A
K
G
G
Q
--
V
E
---
V
V
T
G
EGK
E
L
--
F
S
D
S
L---
A
P
E
G
E
E
G
D
T
F
I
D
M
Y
K
H
N
V
K
L
M
V
K
Y
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.32
27%
-64
- C4 -
4K3V
1
?
A:
[31-304]
-----------------------------
G
K
L
K
V
V
T
T
N
S
I
L
Y
D
M
A
K
N
V
G
G
D
N
V
D
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
V
K
P
K
D
I
K
K
L
T
D
A
D
V
I
L
Y
N
G
L
N
L
E
-
T
GNG
W
F
E
K
A
L
E
Q
A
G
K
S
L
K
D
K
K
V
I
A
-----------
V
S
K
D
V
K
P
I
Y
L
---------------
N
------
D
K
Q
D
P
H
A
W
L
S
L
D
N
G
I
K
Y
V
K
T
I
Q
Q
T
F
I
D
N
D
K
K
H
K
A
D
Y
E
K
Q
G
N
K
Y
I
A
Q
L
E
K
L
N
N
D
S
K
D
K
F
N
D
--
I
PK
E
Q
R
A
M
I
T
S
E
G
A
F
K
Y
F
S
K
Q
Y
G
I
T
P
G
Y
I
W
E
I
N
T
E
K
Q
G
T
P
E
Q
M
R
Q
A
I
E
F
V
K
K
H
K
L
K
H
L
L
V
E
T
-----------------------------
G
E
----
V
--
Y
T
D
S
I---
G
K
E
G
T
K
G
D
S
Y
Y
K
M
M
K
S
N
I
E
T
V
H
G
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
80.22
21%
-49
- C4 -
1TOA
2
TROA_TREPA
A:
[37-313]
-----------------------------
G
K
P
L
V
V
T
T
I
G
M
I
A
D
A
V
K
N
I
A
Q
G
D
V
H
L
K
G
L
M
G
P
G
V
D
P
H
L
Y
T
A
T
A
G
D
V
E
W
L
G
N
A
D
L
I
L
Y
N
G
L
H
L
E
-
T
---
K
M
G
E
----
V
F
S
K
L
R
G
-
S
R
L
V
-----------
V
-
A
V
S
E
T
I
P
V
S
Q
--
R
------------
L
S
L
E
E
A
E
F
D
P
H
V
W
F
D
V
K
L
W
S
Y
S
V
K
A
V
Y
E
S
L
C
K
L
L
P
G
K
T
R
E
F
T
Q
R
Y
Q
A
Y
Q
Q
Q
L
D
K
L
D
A
Y
V
R
R
K
A
Q
S
--
L
PA
E
R
R
V
L
V
T
A
H
D
A
F
G
Y
F
S
R
A
Y
G
F
E
V
K
G
L
Q
G
V
S
T
A
S
E
A
S
A
H
D
M
Q
E
L
A
A
F
I
A
Q
R
K
L
P
A
I
F
I
E
S
S
I
P
H
K
N
V
E
A
L
R
D
A
V
---
Q
A
R
G
H
V
V
---
Q
I
G
G
E
---
L
F
S
D
A
M
G
----
D
A
-
G
T
S
E
G
T
Y
V
G
M
V
T
H
N
I
D
T
I
V
A
A
L
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
79.71
21%
-54
- C4 -
2PRS
3
ZNUA_ECOLI
A:
[1-283]
--------------------------------
A
V
V
A
S
L
K
P
V
G
F
I
A
S
A
I
A
D
G
V
T
E
T
E
V
L
L
P
D
G
A
S
E
H
D
Y
S
L
R
P
S
D
V
K
R
L
Q
N
A
D
L
V
V
W
V
G
P
E
M
E
-
A
---
F
M
Q
K
----
P
V
S
K
L
P
G
A
K
Q
V
T
-----------
I
-
A
Q
L
E
D
V
K
P
L
L
--
M
K
----------------
G
D
F
N
M
H
L
W
L
S
P
E
I
A
R
A
T
A
V
A
I
H
G
K
L
V
E
L
M
P
Q
S
R
A
K
L
D
A
N
L
K
D
F
E
A
Q
L
A
S
T
E
T
Q
V
G
N
E
L
A
P
--
L
--
K
G
K
G
Y
F
V
F
H
D
A
Y
G
Y
F
E
K
Q
F
G
L
T
P
L
G
H
F
T
V
N
P
E
I
Q
P
G
A
Q
R
L
H
E
I
R
T
Q
L
V
E
Q
K
A
T
C
V
F
A
E
P
Q
F
R
P
A
V
V
E
S
V
A
R
G
T
---
S
V
R
--
M
G
---
T
L
D
P
----
L
--
G
T
N
I
----
K
---
L
G
K
T
S
Y
S
E
F
L
S
Q
L
A
N
Q
Y
A
S
C
L
K
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
79.22
23%
-51
- C4 -
1PSZ
1
MTSA_STRPN
A:
[18-303]
----------------------
K
K
D
T
T
S
G
Q
K
L
K
V
V
A
T
N
S
I
I
A
D
I
T
K
N
I
A
G
D
K
I
D
L
H
S
I
V
P
I
G
Q
D
P
H
E
Y
E
P
L
P
E
D
V
K
K
T
S
E
A
D
L
I
F
Y
N
G
I
N
L
E
-
T
---
G
G
N
A
----
W
F
T
K
L
V
E
N
A
K
K
T
-----------
E
-
N
K
-
D
Y
F
A
V
S
D
--
G
V
D
-----
V
I
Y
L
E
G
Q
N
E
K
G
K
E
D
P
H
A
W
L
N
L
E
N
G
I
I
F
A
K
N
I
A
K
Q
L
S
A
K
D
P
N
N
K
E
F
Y
E
K
N
L
K
E
Y
T
D
K
L
D
K
L
D
K
E
S
K
D
K
F
N
K
IP
A
--
E
K
K
L
I
V
T
S
E
G
A
F
K
Y
F
S
K
A
Y
G
V
P
S
A
Y
I
W
E
I
N
T
E
E
E
G
T
P
E
Q
I
K
T
L
V
E
K
L
R
Q
T
K
V
P
S
L
F
V
E
S
S
V
D
D
R
P
M
K
T
V
S
Q
D
T
-------------
N
I
P
I
----
Y
--
A
Q
I
F
T
DSI
A
E
Q
G
K
E
G
D
S
Y
Y
S
M
M
K
Y
N
L
D
K
I
A
E
G
L
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------