@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0670: (2015-12-02 )
MAKIISLGEVLLRLSPPQYHTLMQANHLKCQFGGSELNVLASLAQLGHHVGLVSALPDNDLGKMARQFILSQQISPAAIIKKEGRLGIYYYEQGFSVRTNKVIYDRNYSSFWESTLSDYDFTSIFKGVDWFHVSGITPALTKDLYEVTRFLMTKAKEGGVKVSIDLNFRESLWSSFQEAREQLSPLLGLLDVCFGLEPIYLAGESEDLKDELGLSRPYLDIELLEKITQKIVQEYGLDYIAFTQREMEYTNQYMLKSYLYHNNMLYQTDKTGVEVLDRVGTGDAFAAGLIHALLEKETPQRALEIAMATFKYKHTIQGDINIMTRDDIAYLIEKETNDIKR
Atome Classification :
(20 SA)
.........10........20.-.-.-.....30........40........50........60........-----------70........-80.--........90....---.--..-.100..-...-..110..-.....120...-....130.......140........150.......160.......170....--..--.180.......--190-..--..--.-...200.......210-.-......--220--....-....230.......240.......250...----....260.-......270.-......280.......290.....--------------..300.......310.......320....-....330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
K
I
I
S
L
G
E
V
L
L
RLSPP
Q
Y
H
T
L
-
M
-Q-AN
H
L
K
C
QFGG
S
E
L
N
V
L
A
S
L
A
Q
L
G
H
HVG
L
V
SALPD
N
D
L
G
K
M
A
R
Q
F
I
-----------
L
S
QQIS
P
A
A
I
-
I
-K--KEG
R
L
G
I
Y
Y
Y
EQGF---S--VR-T
N
K
V
I
Y
-DR
N
-
Y
S
S
F
W
E
S
-
T
LSDY
D
F
T
S
I
F-KG
V
D
W
F
H
VSGI
T
P
A
L
T
-
K
D
L
Y
E
V
T
R
F
L
M
T
KAKEG
G
V
K
V
S
I
D
L
N
F
R
E
S
L
W
S
S
F
--
Q
E
--
A
R
E
Q
L
S
P
L
L
G
L
--
L
D
--
V
C
--FG--L-
E
P
I
Y
LAGESE
D
L
K
D
E
L-G-LSRPYL--
D
I
---
E
L
L
E
-
K
I
T
Q
K
I
V
Q
E
YGL
D
Y
I
A
F
T
Q
R
E
M
E
Y
T
N
Q
Y
M
L
----
K
S
Y
L
Y
HNN-
M
L
YQTDKT
G
V
-
E
V
L
D
RVGT
G
D
A
F
A
A
G
L
I
H
A
L
L
EKE--------------T
P
Q
R
A
L
E
I
A
M
A
T
F
K
Y
K
H
TIQG
D
I
-
N
I
M
T
R
-
D
D
I
A
Y
L
I
EKETNDIKR
1
PsiBlast_PDB
99.12
33%
-80
- C2 -
2AFB
5
?
A:
[14-343]
--
K
V
V
T
F
G
E
I
M
L
R
L
S
P
P
D
H
K
R
I
-
F
-
Q
-
T
D
S
F
D
V
T
Y
G
G
A
E
A
N
V
A
A
F
L
A
Q
M
G
L
D
A
Y
F
V
T
K
L
P
N
N
P
L
G
D
A
A
A
G
H
L
-----------
R
K
F
G
V
K
T
D
Y
I
-
A
-
R
--
G
G
N
R
I
G
I
Y
F
L
E
I
G
A
---
S
--
Q
R
-
P
S
K
V
V
Y
-
D
R
A
-
H
S
A
I
S
E
A
-
K
R
E
D
F
D
W
E
K
I
L
-
D
G
A
R
W
F
H
F
S
G
I
T
P
P
L
G
-
K
E
L
P
L
I
L
E
D
A
L
K
V
A
N
E
K
G
V
T
V
S
C
D
L
N
Y
R
A
R
L
W
T
K
---
E
E
--
A
Q
K
V
M
I
P
F
M
E
Y
--
V
D
--
V
-------------
L
I
A
N
E
E
D
I
E
K
V
L
-
G
-
I
S
V
E
G
-----LN
R
E
A
Y
A
-
K
I
A
E
E
V
T
R
K
Y
N
F
K
T
V
G
I
T
L
R
E
S
I
S
A
T
V
N
Y
W
----
S
V
M
V
F
E
N
G
-
Q
P
H
F
S
N
R
Y
E
I
-
H
I
V
D
R
V
G
A
G
D
S
F
A
G
A
L
I
Y
G
S
L
M
G
F
--------------
D
S
Q
K
K
A
E
F
A
A
A
A
S
C
L
K
H
T
I
P
G
D
F
-
V
V
L
S
I
-
E
E
I
E
K
L
A
S
G
-------
3
PsiBlast_PDB
96.89
32%
-85
- C2 -
3KTN
2
?
A:
[4-338]
--
K
I
A
A
F
G
E
V
M
L
R
F
T
P
P
E
Y
L
M
L
-
E
-
Q
-
T
E
Q
L
R
M
N
F
V
G
T
G
V
N
L
L
A
N
L
A
H
F
Q
L
E
T
A
L
I
T
K
L
P
A
N
R
L
G
E
A
G
K
A
A
L
-----------
R
K
L
G
I
S
D
Q
W
V
-
G
-
E
--
K
G
D
H
I
G
S
F
F
A
E
M
G
Y
---
G
--
I
R
-
P
T
Q
V
T
Y
Q
N
R
H
-
Q
S
A
F
G
I
S
-
E
A
K
D
Y
D
F
E
A
F
L
-
A
E
V
D
M
V
H
I
C
G
I
S
L
S
L
T
-
E
K
T
R
D
A
A
L
I
L
A
Q
K
A
H
A
Y
Q
K
K
V
C
F
D
F
N
Y
R
P
S
L
N
T
A
N
--
S
A
L
F
M
R
Q
Q
Y
E
R
I
L
P
Y
--
C
D
--
I
V
--
F
-----------
G
S
R
R
D
L
V
E
L
L
-
G
F
I
P
R
E
D
L
--
E
G
---
E
A
Q
E
T
E
L
I
Q
R
F
M
S
Q
Y
N
L
E
W
F
A
G
T
T
R
S
H
S
-
Q
N
Q
N
Y
L
----
S
G
Y
L
Y
T
Q
N
-
E
Y
Q
Q
S
E
K
R
P
L
-
L
N
L
D
R
I
G
A
G
D
A
Y
A
A
G
I
L
Y
G
Y
S
Q
N
W
--------------
S
L
E
K
A
V
T
F
A
T
V
N
G
V
L
A
H
T
I
Q
G
D
I
-
P
L
T
T
V
-
K
Q
V
N
H
V
L
E
H
P
N
I
D
L
I
R
32
HHSearch
90.53
30%
-75
- C2 -
3KTN
2
?
A:
[2-334]
S
L
K
I
A
A
F
G
E
V
M
L
R
F
T
P
P
E
Y
L
M
L
-
E
-
Q
-
T
E
Q
L
R
M
N
F
V
G
T
G
V
N
L
L
A
N
L
A
H
F
Q
L
E
T
A
L
I
T
K
L
P
A
N
R
L
G
E
A
G
K
A
A
L
-----------
R
K
L
G
I
S
D
Q
W
V
-
G
-
E
--
K
G
D
H
I
G
S
F
F
A
E
M
G
Y
---
G
--
I
--
R
P
T
Q
V
T
-
Y
Q
N
R
H
Q
S
A
F
G
I
S
E
A
K
D
Y
D
F
E
A
F
L
-
A
E
V
D
M
V
H
I
C
G
I
S
L
S
L
T
-
E
K
T
R
D
A
A
L
I
L
A
Q
K
A
H
A
Y
Q
K
K
V
C
F
D
F
N
Y
R
P
S
L
N
T
A
N
S
A
L
F
--
M
R
Q
Q
Y
E
R
I
L
P
Y
--
C
D
--
I
V
--
F
G
--
S
-
R
R
--------
D
L
V
E
L
L
-
G
-
F
I
P
R
E
D
LE
G
E
---
A
Q
E
T
-
E
L
I
Q
R
F
M
S
Q
Y
N
L
E
-----
W
F
A
G
T
T
R
S
H
S
Q
N
Q
N
Y
L
S
G
Y
L
Y
T
Q
N
-
E
Y
Q
Q
S
E
K
R
P
L
-
L
N
L
D
R
I
G
A
G
D
A
Y
A
A
G
I
L
Y
G
Y
S
Q
N
W
--------------
S
L
E
K
A
V
T
F
A
T
V
N
G
V
L
A
H
T
I
Q
G
D
I
-
P
-
L
T
T
V
K
Q
V
N
H
V
L
E
H
P
N
I
D
L
I
R
2
PsiBlast_PDB
89.78
30%
-78
- C2 -
4GM6
2
?
A:
[25-344]
-
K
Q
V
V
T
I
G
E
L
L
M
R
L
S
T
Q
Q
G
I
P
F
-
S
-
Q
-
T
T
A
L
D
I
H
I
G
G
A
E
A
N
V
A
V
N
L
S
K
L
G
H
P
T
R
I
A
T
V
V
P
A
N
P
I
G
K
M
A
V
E
H
L
-----------
W
R
H
Q
V
D
T
A
F
V
-
V
-
E
--
A
G
D
R
L
G
T
Y
Y
L
E
S
G
T
---
A
--
L
K
-
A
P
S
V
V
Y
-
D
R
Q
-
H
S
S
F
A
R
H
-
K
S
M
D
W
D
L
S
E
L
L
-
K
G
I
R
V
L
H
V
S
G
I
T
I
A
L
S
-
T
F
W
L
E
M
V
V
K
I
I
R
E
A
K
R
N
G
I
K
I
S
F
D
M
N
Y
R
A
K
L
W
-
E
L
--
E
A
--
A
K
R
A
Y
Q
Q
L
L
P
L
--
V
D
--
Y
C
--
S
A
G
Q
M
-
D
A
V
A
F
F
E
I
S
S
E
T
T
D
Y
Y
Q
A
-
M
H
D
K
Y
P
--
N
I
---
E
L
F
Y
-
A
----------------
T
K
R
T
V
I
S
A
S
H
H
L
L
----
Q
G
H
L
W
T
Q
G
-
E
C
W
E
S
E
E
Y
A
I
Y
P
I
V
D
R
V
G
G
G
D
A
Y
T
A
A
V
L
H
G
I
L
S
E
W
--------------
R
P
D
E
T
V
K
F
A
T
A
A
A
G
L
K
H
S
I
H
G
D
I
-
N
P
F
D
E
-
K
T
I
A
D
F
A
A
D
-------
9
PsiBlast_PDB
82.83
24%
-66
- C2 -
1WYE
-
?
A:
[2-302]
-
A
K
L
I
T
L
G
E
I
L
I
E
F
N
A
L
S
P
G
P
L
-
R
-
H
-
V
S
Y
F
E
K
H
V
A
G
S
E
A
N
Y
C
V
A
F
I
K
Q
G
N
E
C
G
I
I
A
K
V
G
D
D
E
F
G
Y
N
A
I
E
W
L
-----------
R
G
Q
G
V
D
V
S
H
M
K
I
-
D
--
P
S
A
P
T
G
I
F
F
I
Q
R
H
Y
---
P
--
V
P
L
K
S
E
S
I
Y
-
Y
R
K
-
G
S
A
G
S
K
L
-
S
P
E
D
V
D
E
E
Y
V
--
K
S
A
D
L
V
H
S
S
G
I
T
L
A
I
S
-
S
T
A
K
E
A
----
V
Y
K
A
F
E
I
A
S
N
R
S
F
D
T
N
I
R
L
K
L
W
S
A
---
E
E
--
A
K
R
E
I
L
K
L
L
S
K
--
F
H
--
L
K
--
F
---------
L
I
T
D
T
D
D
S
K
I
I
L
-
G
-
E
S
D
P
D
K
--
A
A
---
K
A
F
S
-
D
Y
A
E
I
I
V
M
K
L
G
P
K
---------------------
G
A
I
V
Y
Y
D
G
-
K
K
Y
Y
S
S
G
Y
Q
V
-
P
V
E
D
V
T
G
A
G
D
A
L
G
G
T
F
L
S
L
Y
Y
K
G
F
--------------
E
M
E
K
A
L
D
Y
A
I
V
A
S
T
L
N
V
M
I
R
G
D
Q
E
N
L
P
T
T
-
K
D
I
E
T
F
L
R
E
M
K
-----
8
PsiBlast_PDB
81.96
24%
-61
- C2 -
2DCN
6
?
A:
[2-302]
-
A
K
L
I
T
L
G
E
I
L
I
E
F
N
A
L
S
P
G
P
L
-
R
-
H
-
V
S
Y
F
E
K
H
V
A
G
S
E
A
N
Y
C
V
A
F
I
K
Q
G
N
E
C
G
I
I
A
K
V
G
D
D
E
F
G
Y
N
A
I
E
W
L
-----------
R
G
Q
G
V
D
V
S
H
M
K
I
-
D
--
P
S
A
P
T
G
I
F
F
I
Q
R
H
Y
---
P
--
V
P
L
K
S
E
S
I
Y
-
Y
R
K
-
G
S
A
G
S
K
L
-
S
P
E
D
V
D
E
E
Y
V
--
K
S
A
D
L
V
H
S
S
G
I
T
L
A
I
S
-
S
T
A
K
E
A
----
V
Y
K
A
F
E
I
A
S
N
R
S
F
D
T
N
I
R
L
K
L
W
S
A
---
E
E
--
A
K
R
E
I
L
K
L
L
S
K
--
F
H
--
L
K
--
F
---------
L
I
T
D
T
D
D
S
K
I
I
L
-
G
-
E
S
D
P
D
K
--
A
A
---
K
A
F
S
-
D
Y
A
E
I
I
V
M
K
L
G
P
K
---------------------
G
A
I
V
Y
Y
D
G
-
K
K
Y
Y
S
S
G
Y
Q
V
-
P
V
E
D
V
T
G
A
G
D
A
L
G
G
T
F
L
S
L
Y
Y
K
G
F
--------------
E
M
E
K
A
L
D
Y
A
I
V
A
S
T
L
N
V
M
I
R
G
D
Q
E
N
L
P
T
T
-
K
D
I
E
T
F
L
R
E
M
------
40
HHSearch
80.11
24%
-61
- C2 -
2DCN
6
?
A:
[2-309]
-
A
K
L
I
T
L
G
E
I
L
I
E
F
N
A
L
S
P
G
P
L
-
R
-
H
-
V
S
Y
F
E
K
H
V
A
G
S
E
A
N
Y
C
V
A
F
I
K
Q
G
N
E
C
G
I
I
A
K
V
G
D
D
E
F
G
Y
N
A
I
E
W
L
-----------
R
G
Q
G
V
D
V
S
H
M
-
K
-
I
D
-
P
S
A
P
T
G
I
F
F
I
Q
R
H
Y
PVP
L
--
K
--
S
E
S
I
Y
Y
-
R
K
G
--
S
A
G
S
K
L
-
S
P
E
D
V
D
E
E
-
Y
V
-
K
S
A
D
L
V
H
S
S
G
I
T
L
A
I
S
-
S
T
A
K
E
A
V
Y
K
A
F
E
I
A
----
S
N
R
S
F
D
T
N
I
R
L
K
L
W
S
A
E
---
E
--
A
K
R
E
I
L
K
L
L
S
K
F
H
L
K
--
F
L
--
I
T
--
D
-
T
D
--------
D
S
K
I
I
L
-
G
-
E
S
D
------------
P
D
-
K
A
A
K
A
F
S
-
D
-
Y
A
E
-----
I
I
V
M
K
L
G
P
K
G
-------
A
I
V
Y
Y
D
G
-
K
K
Y
Y
S
S
G
Y
Q
V
-
P
V
E
D
V
T
G
A
G
D
A
L
G
G
T
F
L
S
L
Y
Y
K
G
F
--------------
E
M
E
K
A
L
D
Y
A
I
V
A
S
T
L
N
V
M
I
R
G
D
Q
-
E
N
L
P
T
T
K
D
I
E
T
F
L
R
E
M
------
38
HHSearch
79.00
24%
-66
- C2 -
2V78
-
KDGK_SULSO
A:
[2-311]
-
V
D
V
I
A
L
G
E
P
L
I
Q
F
N
S
F
N
P
G
P
L
-
R
-
F
-
V
N
Y
F
E
K
H
V
A
G
S
E
L
N
F
C
I
A
V
V
R
N
H
L
S
C
S
L
I
A
R
V
G
N
D
E
F
G
K
N
I
I
E
Y
S
-----------
R
A
Q
G
I
D
T
S
H
I
-
K
-
V
D-
N
E
S
F
T
G
I
Y
F
I
Q
R
G
Y
---
P
IP
M
--
K
S
E
L
V
Y
-
Y
R
K
-
G
S
A
G
S
R
L
-
S
P
E
D
I
N
E
N
-
Y
V
-
R
N
S
R
L
V
H
S
T
G
I
T
L
A
I
S
-
D
N
A
K
E
A
V
I
K
A
F
E
L
A
K
S
R
----
S
L
D
T
N
I
R
P
K
L
W
S
S
L
--
E
K
--
A
K
E
T
I
L
S
I
L
K
K
--
Y
D
IE
V
L
--
I
T
--
D
-
P
D
--------
D
T
K
I
L
L
-
D
-
V
T
D
------------
P
D
-
E
A
Y
R
K
Y
K
E
-
L
G
V
K
-----
V
L
L
Y
K
L
G
S
K
G
-------
A
I
A
Y
K
D
N
-
V
K
A
F
K
D
A
Y
K
V
-
P
V
E
D
P
T
G
A
G
D
A
M
A
G
T
F
V
S
L
Y
L
Q
G
K
--------------
D
I
E
Y
S
L
A
H
G
I
A
A
S
T
L
V
I
T
V
R
G
D
N
-
E
L
T
P
T
L
E
D
A
E
R
F
L
N
E
F
K
-----
10
PsiBlast_PDB
77.92
23%
-65
- C2 -
2V78
-
KDGK_SULSO
A:
[2-294]
-
V
D
V
I
A
L
G
E
P
L
I
Q
F
N
S
F
N
P
G
P
L
-
R
-
F
-
V
N
Y
F
E
K
H
V
A
G
S
E
L
N
F
C
I
A
V
V
R
N
H
L
S
C
S
L
I
A
R
V
G
N
D
E
F
G
K
N
I
I
E
Y
S
-----------
R
A
Q
G
I
D
T
S
H
I
K
V
-
D
--
N
E
S
F
T
G
I
Y
F
I
Q
R
G
Y
---
P
--
I
P
M
K
S
E
L
V
Y
-
Y
R
K
-
G
S
A
--
G
S
-
R
L
S
P
E
D
I
N
E
N
Y
V
R
N
S
R
L
V
H
S
T
G
I
T
L
A
I
S
-
D
N
A
K
E
A
----
V
I
K
A
F
E
L
A
K
S
R
S
L
D
T
N
I
R
P
K
L
W
S
S
L
--
E
K
--
A
K
E
T
I
L
S
I
L
K
K
--
Y
D
--
I
E
--
V
---------
L
I
T
D
P
D
D
T
K
I
L
L
-
D
-
V
T
D
P
------------
D
-
E
A
Y
R
K
-
Y
K
E
L
G
V
K
V
L
L
Y
K
L
G
S
K
------------
G
A
I
A
Y
K
D
N
-
V
K
A
F
K
D
A
Y
K
V
-
P
V
E
D
P
T
G
A
G
D
A
M
A
G
T
F
V
S
L
Y
L
Q
G
K
--------------
D
I
E
Y
S
L
A
H
G
I
A
A
S
T
L
V
I
T
V
R
G
D
N
-
E
L
T
P
T
-
L
E
D
A
E
R
F
L
N
E
F
K
----
11
PsiBlast_PDB
77.25
23%
-65
- C2 -
2VAR
4
KDGK_SULSO
A:
[2-294]
-
V
D
V
I
A
L
G
E
P
L
I
Q
F
N
S
F
N
P
G
P
L
-
R
-
F
-
V
N
Y
F
E
K
H
V
A
G
S
E
L
N
F
C
I
A
V
V
R
N
H
L
S
C
S
L
I
A
R
V
G
N
D
E
F
G
K
N
I
I
E
Y
S
-----------
R
A
Q
G
I
D
T
S
H
I
K
V
-
D
--
N
E
S
F
T
G
I
Y
F
I
Q
R
G
Y
---
P
--
I
P
M
K
S
E
L
V
Y
-
Y
R
K
-
G
S
A
--
G
S
-
R
L
S
P
E
D
I
N
E
N
Y
V
R
N
S
R
L
V
H
S
T
G
I
T
L
A
I
S
-
D
N
A
K
E
A
----
V
I
K
A
F
E
L
A
K
S
R
S
L
D
T
N
I
R
P
K
L
W
S
S
L
--
E
K
--
A
K
E
T
I
L
S
I
L
K
K
--
Y
D
--
I
E
--
V
---------
L
I
T
D
P
D
D
T
K
I
L
L
-
D
-
V
T
D
P
------------
D
-
E
A
Y
R
K
-
Y
K
E
L
G
V
K
V
L
L
Y
K
L
G
S
K
------------
G
A
I
A
Y
K
D
N
-
V
K
A
F
K
D
A
Y
K
V
-
P
V
E
D
P
T
G
A
G
D
A
M
A
G
T
F
V
S
L
Y
L
Q
G
K
--------------
D
I
E
Y
S
L
A
H
G
I
A
A
S
T
L
V
I
T
V
R
G
D
N
-
E
L
T
P
T
-
L
E
D
A
E
R
F
L
N
E
F
K
----
7
PsiBlast_PDB
73.38
28%
-71
- C2 -
1V1S
-
KDGK_THET8
A:
[1-256]
M
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
-
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
-----------
R
A
E
G
V
D
L
T
H
F
-
R
-
R
--
A
P
G
F
T
G
L
Y
L
R
E
Y
-
L
---
P
--
L
G
-
Q
G
R
V
F
Y
-
Y
R
K
-
G
S
A
--
G
S
-
A
L
A
P
G
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
S
-
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
---
E
E
--
A
R
G
F
L
E
R
A
L
P
G
--
V
D
--
L
L
--
F
----------------
L
S
E
E
------------
E
A
---
E
L
L
F
-
G
R
V
E
E
A
L
R
-------
A
L
S
A
P
E
V
-
V
L
K
R
G
A
K
----
G
A
W
A
F
V
D
G
-
R
R
V
E
G
S
A
F
A
V
-
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
-
E
G
A
P
Y
-
R
E
D
L
E
V
L
L
K
-------
28
HHSearch
72.50
20%
-60
* C2 *
3IQ0
2
?
A:
[4-313]
-
S
K
V
F
T
I
G
E
I
L
V
E
I
M
A
S
K
I
G
Q
P
-
F
D
Q
P
G
I
W
N
G
P
Y
P
S
G
A
P
A
I
F
I
D
Q
V
T
R
L
G
V
P
C
G
I
I
S
C
V
G
N
D
G
F
G
D
I
N
I
H
R
L
-----------
A
A
D
G
V
D
I
R
G
I
-
S
-
V
L
-
P
L
E
A
T
G
S
A
F
V
T
Y
H
N
----------
R
D
F
I
F
-
N
I
K
-
N
A
A
C
G
K
L
-
S
A
Q
H
V
D
E
N
-
I
L
-
K
D
C
T
H
F
H
I
M
G
S
S
L
F
-
S
-
F
H
M
V
D
A
V
K
K
A
V
T
I
V
K
A
N
G
G
V
I
S
F
D
P
N
I
R
K
E
M
L
D
I
---
P
E
--
M
R
D
A
L
H
F
V
L
E
L
--
T
D
--
I
Y
--
M
P
--
S
-
E
G
--------
E
V
L
L
L
S
-
P
-
H
S
T
------------
P
E
-
R
A
I
A
G
F
L
E
E
-
G
V
K
-----
E
V
I
V
K
R
G
N
Q
G
-------
A
S
Y
Y
S
A
N
-
E
Q
F
H
V
E
S
Y
P
V
-
E
E
V
D
P
T
G
A
G
D
C
F
G
G
A
W
I
A
C
R
Q
L
G
F
--------------
D
A
H
R
A
L
Q
Y
A
N
A
C
G
A
L
A
V
T
R
R
G
P
M
-
E
G
T
S
R
L
M
E
I
E
T
F
I
Q
R
H
------
4
PsiBlast_PDB
72.46
28%
-74
- C2 -
1V19
1
KDGK_THET8
A:
[1-256]
M
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
-
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
-----------
R
A
E
G
V
D
L
T
H
F
-
R
-
R
--
A
P
G
F
T
G
L
Y
L
R
E
Y
-
L
---
P
--
L
G
-
Q
G
R
V
F
Y
-
Y
R
K
-
G
S
A
--
G
S
-
A
L
A
P
G
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
S
-
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
---
E
E
--
A
R
G
F
L
E
R
A
L
P
G
--
V
D
--
L
L
--
F
----------------
L
S
E
E
------------
E
A
---
E
L
L
F
-
G
R
V
E
E
A
L
R
-------
A
L
S
A
P
E
V
-
V
L
K
R
G
A
K
----
G
A
W
A
F
V
D
G
-
R
R
V
E
G
S
A
F
A
V
-
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
-
E
G
A
P
Y
-
R
E
D
L
E
V
L
L
K
-------
12
PsiBlast_PDB
71.69
23%
-83
- C2 -
4DU5
1
?
A:
[29-297]
---
V
I
T
F
G
E
A
M
M
L
L
V
A
D
R
P
G
P
L
-
E
-
H
-
A
E
A
F
H
K
R
T
A
G
A
E
T
N
V
A
I
G
L
A
R
L
G
L
K
V
G
W
A
S
R
L
G
T
D
S
M
G
R
Y
L
L
A
A
M
-----------
A
A
E
G
I
D
C
S
H
V
-
V
C
D
--
A
T
Q
K
T
G
F
Q
F
K
G
K
V
T
---
D
--
G
---
P
P
V
E
Y
-
H
R
K
-
G
S
A
A
S
H
M
-
G
V
A
D
I
D
E
A
W
L
L
-
S
-
A
R
H
L
H
A
T
G
V
F
P
A
I
S
-
A
T
T
L
P
A
A
R
K
T
M
D
L
M
R
A
A
G
R
S
V
S
F
D
P
N
L
R
P
T
L
W
A
T
P
--
E
L
--
M
R
D
A
I
N
D
L
A
T
R
--
A
D
W
-
V
L
--
P
G
--
M
E
E
G
R
F
L
T
G
E
T
T
----
P
E
-
G
-
V
A
R
F
Y
R
--
Q
L
---
G
A
K
L
-
V
V
V
K
L
G
A
E
G
A
Y
F
D
G
E
A
G
S
G
R
V
A
G
F
P
----------------------------------
V
G
A
G
D
G
F
A
V
G
V
I
S
A
L
L
D
G
L
--------------
G
V
P
E
A
V
K
R
G
A
W
I
G
A
R
A
V
Q
G
L
P
T
R
-
A
E
L
N
A
-
A
---------------
25
HHSearch
71.62
17%
-67
- C2 -
2QCV
2
IOLC_BACHD
A:
[11-328]
E
F
D
L
I
A
I
G
R
A
C
I
D
L
N
A
V
E
Y
N
R
P
M
E
-
E
-
T
M
T
F
S
K
Y
V
G
G
S
P
A
N
I
V
I
G
S
S
K
L
G
L
K
A
G
F
I
G
K
I
A
D
D
Q
H
G
R
F
I
E
S
Y
M
-----------
R
G
V
G
V
D
T
S
N
L
-
V
-
V
DQ
E
G
H
K
T
G
L
A
F
T
E
I
K
S
---
P
--
E
--
E
C
S
I
L
M
-
Y
R
Q
-
D
V
A
D
L
Y
L
-
S
P
E
E
V
N
E
A
-
Y
I
-
R
R
S
K
L
L
L
V
S
G
T
A
L
S
K
S
-
P
S
-
R
E
A
V
L
K
A
I
R
L
A
K
R
N
D
V
K
V
V
F
E
L
D
Y
R
P
Y
S
W
E
T
P
--
E
E
--
T
A
V
Y
Y
S
L
V
A
E
Q
--
S
D
--
I
V
--
I
G
--
T
-
R
E
--------
E
F
D
V
L
E
-
N
-
R
T
E
K
---------
G
D
N
D
-
E
T
I
R
Y
L
F
K
H
-
S
P
E
-----
L
I
V
I
K
H
G
V
E
G
-------
S
F
A
Y
T
K
A
G
E
A
Y
R
G
Y
A
Y
K
T
-
K
V
L
K
T
F
G
A
G
D
S
Y
A
S
A
F
L
Y
A
L
I
S
G
K
--------------
G
I
E
T
A
L
K
Y
G
S
A
S
A
S
I
V
V
S
K
------
A
M
P
S
V
E
E
I
E
A
L
I
E
K
D
E
T
I
T
I
A
16
PsiBlast_PDB
71.42
23%
-70
- C2 -
1TYY
2
?
A:
[25-292]
-
N
K
V
W
V
I
G
D
A
S
V
D
L
V
P
E
K
-------
Q
-
N
S
Y
L
K
C
P
-
G
G
A
S
A
N
V
G
V
C
V
A
R
L
G
G
E
C
G
F
I
G
C
L
G
D
D
D
A
G
R
F
L
R
Q
V
F
Q
D
N
GVDVTF
L
R
L
D
A
D
L
T
S
A
V
L
-
I
-
V
--
N
-----------
S
F
---
T
--
Y
L
-
V
H
P
G
A
-----------
D
T
-
Y
V
S
P
Q
D
L
P
P
-
F
-
R
Q
Y
E
W
F
Y
F
S
S
I
--
G
L
T
D
R
P
A
R
E
A
C
L
E
G
A
R
R
M
R
E
A
G
G
Y
V
L
F
D
V
N
L
R
S
K
M
W
G
N
T
--
D
E
--
I
P
E
L
I
A
R
S
A
A
L
--
A
S
--
I
C
K
V
S
A
--
D
-
E
L
C
Q
L
S
G
A
S
H
-
W
Q
D
------
A
R
Y
Y
---------
L
R
D
-
L
G
C
D
T
T
I
I
S
L
G
A
D
G
A
L
L
I
T
A
E
G
E
----------------------
F
H
F
P
A
P
R
V
-
D
V
V
D
T
T
G
A
G
D
A
F
V
G
G
L
L
F
T
L
S
R
A
N
--------------
C
W
D
H
A
L
L
A
E
A
I
S
N
A
N
A
C
G
A
M
A
V
T
-
A
K
G
A
M
-
T
A
L
P
F
P
D
Q
L
N
T
F
L
S
--
17
PsiBlast_PDB
71.35
23%
-69
- C2 -
1TZ3
3
?
A:
[25-292]
-
N
K
V
W
V
I
G
D
A
S
V
D
L
V
P
E
K
-------
Q
-
N
S
Y
L
K
C
P
-
G
G
A
S
A
N
V
G
V
C
V
A
R
L
G
G
E
C
G
F
I
G
C
L
G
D
D
D
A
G
R
F
L
R
Q
V
F
Q
D
N
GVDVTF
L
R
L
D
A
D
L
T
S
A
V
L
-
I
-
V
--
N
-----------
S
F
---
T
--
Y
L
-
V
H
P
G
A
-----------
D
T
-
Y
V
S
P
Q
D
L
P
P
-
F
-
R
Q
Y
E
W
F
Y
F
S
S
I
--
G
L
T
D
R
P
A
R
E
A
C
L
E
G
A
R
R
M
R
E
A
G
G
Y
V
L
F
D
V
N
L
R
S
K
M
W
G
N
T
--
D
E
--
I
P
E
L
I
A
R
S
A
A
L
--
A
S
--
I
C
K
V
S
A
--
D
-
E
L
C
Q
L
S
G
A
S
H
-
W
Q
D
------
A
R
Y
Y
---------
L
R
D
-
L
G
C
D
T
T
I
I
S
L
G
A
D
G
A
L
L
I
T
A
E
G
E
----------------------
F
H
F
P
A
P
R
V
-
D
V
V
D
T
T
G
A
G
D
A
F
V
G
G
L
L
F
T
L
S
R
A
N
--------------
C
W
D
H
A
L
L
A
E
A
I
S
N
A
N
A
C
G
A
M
A
V
T
-
A
K
G
A
M
-
T
A
L
P
F
P
D
Q
L
N
T
F
L
S
S
H
31
HHSearch
71.06
21%
-59
- C2 -
1TYY
2
?
A:
[25-328]
-
N
K
V
W
V
I
G
D
A
S
V
D
L
V
P
E
K
Q
---------
N
S
Y
L
K
C
P
G
G
A
S
A
N
V
G
V
C
V
A
R
L
G
G
E
C
G
F
I
G
C
L
G
D
D
D
A
G
R
F
L
R
Q
V
F
-----------
Q
D
N
G
V
D
V
T
F
L
-
R
-
L
D
-
A
D
L
T
S
A
V
L
I
V
N
--------------
S
F
T
Y
-
L
V
H
-
P
G
A
D
T
Y
V
-
S
P
Q
D
L
P
---
P
F
-
R
Q
Y
E
W
F
Y
F
S
S
I
G
L
T
D
R
-
P
-
A
R
E
A
C
L
E
G
A
R
R
M
R
E
A
G
G
Y
V
L
F
D
V
N
L
R
S
K
M
W
G
N
T
--
D
E
--
I
P
E
L
I
A
R
S
A
A
L
--
A
S
--
I
C
--
K
V
--
S
-
A
D
--------
E
L
C
Q
L
S
-
G
-
A
S
H
------------
W
Q
-
D
A
R
Y
Y
L
R
D
-
L
G
C
D
-----
T
T
I
I
S
L
G
A
D
G
-------
A
L
L
I
T
A
E
-
G
E
F
H
F
P
A
P
R
V
-
D
V
V
D
T
T
G
A
G
D
A
F
V
G
G
L
L
F
T
L
S
R
A
N
CWD
H
A
---------
L
L
A
E
A
I
S
N
A
N
A
C
G
A
M
A
V
T
A
K
G
A
M
-
T
A
L
P
F
P
D
Q
L
N
T
F
L
S
--------
5
PsiBlast_PDB
70.99
28%
-71
- C2 -
1V1A
2
KDGK_THET8
A:
[1-256]
M
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
-
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
-----------
R
A
E
G
V
D
L
T
H
F
-
R
-
R
--
A
P
G
F
T
G
L
Y
L
R
E
Y
-
L
---
P
--
L
G
-
Q
G
R
V
F
Y
-
Y
R
K
-
G
S
A
--
G
S
-
A
L
A
P
G
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
S
-
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
---
E
E
--
A
R
G
F
L
E
R
A
L
P
G
--
V
D
--
L
L
--
F
----------------
L
S
E
E
------------
E
A
---
E
L
L
F
-
G
R
V
E
E
A
L
R
-------
A
L
S
A
P
E
V
-
V
L
K
R
G
A
K
----
G
A
W
A
F
V
D
G
-
R
R
V
E
G
S
A
F
A
V
-
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
-
E
G
A
P
Y
-
R
E
D
L
E
V
L
L
K
-------
27
HHSearch
70.92
20%
-76
- C2 -
3LJS
-
?
A:
[4-331]
K
K
T
I
L
C
F
G
E
A
L
I
D
M
L
A
Q
P
L
V
K
K
-
G
-
M
-
P
R
A
F
L
Q
C
A
G
G
A
P
A
N
V
A
V
A
V
A
R
L
G
G
A
V
Q
F
V
G
M
L
G
S
D
M
F
G
D
F
L
F
D
S
F
-----------
A
E
A
G
V
V
T
D
G
I
-
V
-
R
T
-
S
T
A
K
T
A
L
A
F
V
A
L
D
A
---
H
--
G
--
E
R
S
F
S
F
-
Y
R
P
-
P
A
A
D
L
L
F
-
R
V
E
H
F
Q
D
A
-
S
F
-
S
D
A
L
I
F
H
A
C
S
N
S
M
T
D
--
A
D
I
A
E
V
T
F
E
G
M
R
R
A
Q
A
A
G
A
I
V
S
F
D
L
N
F
R
P
M
L
W
P
N
G
--
E
N
--
P
A
S
R
L
W
K
G
L
S
L
--
A
D
--
V
V
--
K
L
--
S
-
S
E
--------
E
L
D
Y
L
A
-
N
-
T
L
A
A
----------
D
A
N
-
A
V
I
Q
Q
L
W
Q
G
-
R
A
Q
-----
L
L
L
V
T
D
A
A
G
P
-------
V
H
W
Y
T
R
T
-
A
G
G
E
V
P
T
------------
G
D
A
F
V
G
G
M
L
Y
T
F
A
Q
Q
F
DD
A
A
A
L
I
D
F
C
H
D
P
E
S
I
V
S
T
L
R
F
A
A
A
V
G
A
L
A
V
----
A
F
-
T
A
M
P
M
L
S
E
V
L
S
L
I
Q
E
Q
S
E
----