@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0675: (2015-12-02 )
MEMSFRWYGEDDPVTLENIGQIPTMKGIVTAIYDVPVGEVWSRERIQQLKEKVEAAGLKISVIESVPVHEDIKLGRPTRDLLIDNYIQTVKNLAAEGIDTICYNFMPVFDWTRTDLAYQYPDGSTALIFDETVSKKMDPVNGELSLPGWDASYSKEEMKAIMDAYAEIDEEKLWENLTYFIKRIIPEAEAVGVKMAIHPDDPPYSIFGLPRIITGLEAIERFVKLYDSKSNGITLCVGSYASDPQNDVLEISRRAFELDRVNFVHARNIKLGDGKSFKESAHPSEYGSIDMYEVIKLCHEFGFEGAIRPDHGRMIWGETGRPGYGLYDRALGATYLSGLYEAVIKGSK
Atome Classification :
(20 SA)
.........10.........20........30........40........50........60........---70..-----.-.---....80........90........100.......110.......120.......130----------------------------.........---------140------....------....150.......160...-..-..170.......180.......190.......200.......210.......220.......230.......240.......250....--...260.......270..-----.-.--------------.--..280.......290......----.300....-----...310.....-.-.320--------.---...---.....330.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
M
S
F
R
W
YGE-DDPV
T
L
E
NIGQIP
T
M
K
G
I
V
T
A
I
YDV
P
V
G
E
V
W
S
R
E
R
I
Q
Q
L
K
E
K
V
E
AAG
L
K
I
S
V
I
ESVPVH---EDIK-----L-G---R
P
T
R
D
L
L
I
D
N
Y
I
Q
T
V
K
N
L
A
A
E
G
I
D
T
I
C
Y
NFMPVFDWTRT
D
L
A
Y
QYPDG
S
T
A
L
I
F
D
------------------------------
E
T
V
S
KKMDP---------VN-------GELS------LPGWDASY
S
K
E
E
M
K
A
I
M
D
A
Y
-
A
E-I
D
E
E
K
L
W
E
N
L
T
Y
F
I
K
R
IIPE
A
E
AV
G
V
K
M
A
IHPDDPP
Y
S
IF
G
L
P
R
I
I
T
G
L
E
A
I
E
R
F
V
K
L
YDSKSN
G
I
T
L
C
VGSYASDP
Q
N
D
V
L
E
I
S
R
R
A
F--ELD
R
V
N
F
V
H
A
R
N
I
KLGDG-----K-S--------------F--KESAHPSEYGSI
D
M
Y
E
V
I
K
L
C
----
H
EFGFEGA-----IRPDHG
R
M
I
WG-E-TG----------R---PGY---
G
L
Y
D
R
A
L
G
A
T
Y
L
S
G
L
Y
E
A
V
IKGSK
2
PsiBlast_PDB
98.87
62%
-103
- C2 -
3BDK
2
UXUA_STRSY
A:
[21-368]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
------------------------------------
S
K
E
E
M
K
A
I
I
E
N
Y
-
R
Q
N
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
--
K
R
N
R
I
N
F
M
H
T
R
N
V
T
A
G
-
A
-----
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
D
Q
-
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
4
PsiBlast_PDB
98.82
62%
-102
- C2 -
3FVM
1
UXUA_STRSY
A:
[21-368]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
------------------------------------
S
K
E
E
M
K
A
I
I
E
N
Y
-
R
Q
N
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
--
K
R
N
R
I
N
F
M
H
T
R
N
V
T
A
G
-
A
-----
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
D
Q
-
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
1
PsiBlast_PDB
98.82
62%
-102
- C2 -
3BAN
-
UXUA_STRSY
A:
[21-368]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
------------------------------------
S
K
E
E
M
K
A
I
I
E
N
Y
-
R
Q
N
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
--
K
R
N
R
I
N
F
M
H
T
R
N
V
T
A
G
-
A
-----
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
D
Q
-
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
3
PsiBlast_PDB
98.66
62%
-99
- C2 -
3DBN
2
UXUA_STRSY
A:
[21-368]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
------------------------------------
S
K
E
E
M
K
A
I
I
E
N
Y
-
R
Q
N
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
--
K
R
N
R
I
N
F
M
H
T
R
N
V
T
A
G
-
A
-----
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
D
Q
-
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
21
PsiBlast_CBE
98.50
62%
-101
- C2 -
3DBN
1
UXUA_STRSY
B:
[21-368]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
---------
V
A
--------------------------------
I
I
E
N
Y
-
R
Q
N
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
--
K
R
N
R
I
N
F
M
H
T
R
N
V
T
A
G
-
A
-----
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
D
Q
-
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
28
HHSearch
98.43
64%
-102
- C2 -
3BDK
2
UXUA_STRSY
A:
[21-366]
M
K
M
S
F
R
W
Y
G
K
-
K
D
P
V
T
L
E
E
I
K
A
I
P
G
M
Q
G
I
V
T
A
V
Y
D
V
P
V
G
Q
A
W
P
L
E
N
I
L
E
L
K
K
M
V
E
E
A
G
L
E
I
T
V
I
E
S
I
P
V
H
---
E
D
I
K
-----
Q
-
G
---
K
P
N
R
D
A
L
I
E
N
Y
K
T
S
I
R
N
V
G
A
A
G
I
P
V
V
C
Y
N
F
M
P
V
F
D
W
T
R
S
D
L
H
H
P
L
P
D
G
S
T
S
L
A
F
L
------------------------------
K
S
D
L
A
G
V
D
P
------------------------------------
S
K
E
E
M
K
A
I
I
E
N
Y
R
Q
N
-
I
S
E
E
D
L
W
A
N
L
E
Y
F
I
K
A
I
L
P
T
A
E
E
A
G
V
K
M
A
I
H
P
D
D
P
P
Y
G
I
F
G
L
P
R
I
I
T
G
Q
E
A
V
E
R
F
L
N
L
Y
D
S
E
H
N
G
I
T
M
C
V
G
S
Y
A
S
D
P
K
N
D
V
L
A
M
T
E
Y
A
L
K
R
N
--
R
I
N
F
M
H
T
R
N
V
T
A
G
A
------
W
-
G
--------------
F
--
Q
E
T
A
H
L
S
Q
A
G
D
I
D
M
N
A
V
V
K
L
L
----
V
D
Y
D
W
Q
G
S
-----
L
R
P
D
H
G
R
R
I
W
G
-
D
Q
T
K
----------
T
---
P
G
Y
---
G
L
Y
D
R
A
L
G
A
T
Y
F
N
G
L
Y
E
A
N
M
R
A
A
G
22
PsiBlast_CBE
84.43
39%
-92
- C2 -
4EAY
2
UXUA_ECOLI
D:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
24
PsiBlast_CBE
84.38
39%
-91
- C2 -
4EAY
3
UXUA_ECOLI
B:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
7
PsiBlast_PDB
84.32
39%
-92
- C2 -
4EAY
3
UXUA_ECOLI
A:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
Q
I
E
F
A
A
F
E
M
HILKRPGAEADYT
E
E
E
I
A
Q
A
A
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
R
N
I
IAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
V
E
E
E
H
R
R
K
A
E
G
K
E
D
L
I
P
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
6
PsiBlast_PDB
84.28
39%
-91
- C2 -
4EAC
2
UXUA_ECOLI
A:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
Q
I
E
F
A
A
F
E
M
HILKRPGAEADYT
E
E
E
I
A
Q
A
A
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
R
N
I
IAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
V
E
E
E
H
R
R
K
A
E
G
K
E
D
L
I
P
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
27
PsiBlast_CBE
84.25
39%
-95
- C2 -
4EAC
2
UXUA_ECOLI
B:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
23
PsiBlast_CBE
84.14
39%
-92
- C2 -
4EAY
2
UXUA_ECOLI
C:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
26
PsiBlast_CBE
83.77
39%
-91
- C2 -
4EAC
2
UXUA_ECOLI
C:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
25
PsiBlast_CBE
83.62
39%
-92
- C2 -
4EAC
2
UXUA_ECOLI
D:
[21-410]
M
E
Q
T
W
R
W
Y
G
P
-
N
D
P
V
S
L
A
D
V
R
Q
A
G
A
T
-
G
V
V
T
A
L
H
H
I
P
N
G
E
V
W
S
V
E
E
I
L
K
R
K
A
I
I
E
D
A
G
L
V
W
S
V
V
E
S
V
P
I
H
---
E
D
I
K
-----
T
-
H
---
T
G
N
Y
E
Q
W
I
A
N
Y
Q
Q
T
L
R
N
L
A
Q
C
G
I
R
T
V
C
Y
N
F
M
P
V
L
D
W
T
R
T
D
L
E
Y
V
L
P
D
G
S
K
A
L
R
F
D
QIEFAAFEMHILKRPGAEADYTEEEIAQAA
E
R
F
A
T
M
S
D
E
---------
D
K
-------
A
R
L
T
RNIIAG
L
P
G
A
E
E
G
Y
T
L
D
Q
F
R
K
H
L
E
L
Y
-
K
D
-
I
D
K
A
K
L
R
E
N
F
A
V
F
L
K
A
I
I
P
V
A
E
E
V
G
V
R
M
A
V
H
P
D
D
P
P
R
P
I
L
G
L
P
R
I
V
S
T
I
E
D
M
Q
W
M
V
D
T
V
N
S
M
A
N
G
F
T
M
C
T
G
S
Y
G
V
R
A
D
N
D
L
V
D
M
I
K
Q
F
G
--
P
--
R
I
Y
F
T
H
L
R
S
T
M
R
E
D
N
P----
K
-
T
--------------
F
--
H
E
A
A
H
L
N
--
G
D
V
D
M
Y
E
V
V
K
A
I
VEEE
H
R
R
K
A
E
G
K
EDLIP
M
R
P
D
H
G
H
Q
M
L
D
-
D
-
L
K
----------
K
KTN
P
G
Y
---
S
A
I
G
R
L
K
G
L
A
E
V
R
G
V
E
L
A
I
Q
R
A
F
F
5
PsiBlast_PDB
74.94
46%
-45
- C2 -
1TZ9
-
UXUA_ENTFA
A:
[5-350]
----
F
R
W
Y
G
A
A
G
D
A
I
P
L
K
H
I
R
Q
I
P
G
I
T
G
V
V
G
T
L
L
N
K
L
P
G
D
V
W
T
V
A
E
I
Q
A
L
K
Q
S
V
E
Q
E
G
L
A
L
L
G
I
E
S
V
A
I
H
---
D
A
I
K
-----
A
-
G
---
T
D
Q
R
D
H
Y
I
D
N
Y
R
Q
T
L
R
N
L
G
K
C
G
I
S
L
V
C
Y
S
F
K
P
I
F
G
W
A
K
T
D
L
A
Y
E
N
E
D
G
S
L
S
L
L
F
D
------------------------------
Q
A
V
V
E
N
M
Q
P
E
D
M
Y
Q
L
I
H
S----------------------
W
E
E
E
-
R
L
Q
Q
F
Q
E
L
K
A
M
Y
-
A
G
-
V
T
E
E
D
L
V
E
N
L
R
Y
F
L
E
R
V
I
P
V
C
E
E
E
N
I
K
M
G
I
H
P
D
D
P
P
W
E
I
F
G
L
P
R
I
T
K
N
L
A
D
L
K
R
I
L
S
L
V
D
S
P
A
N
G
I
T
F
C
T
G
S
L
G
A
D
P
T
N
D
L
P
T
M
I
R
E
I
G
--
H
--
R
I
N
F
V
H
F
R
N
V
K
Y
L
G
E
-----
H
-
R
--------------
F
--
E
E
T
A
H
P
S
V
A
G
S
L
D
M
A
E
L
M
Q
A
L
----
V
D
V
G
Y
E
G
V
-----
I
R
P
D
H
G
R
A
I
W
D
-
E
-
K
A
----------
M
---
P
G
Y
---
G
L
Y
D
R
A
M
G
L
T
Y
I
Q
G
L
Y
E
A
T
K
A
K
--
29
HHSearch
58.93
47%
10
- C2 -
1TZ9
-
UXUA_ENTFA
A:
[1-353]
M
K
W
G
F
R
W
Y
G
A
A
G
D
A
I
P
L
K
H
I
R
Q
I
P
G
I
T
G
V
V
G
T
L
L
N
K
L
P
G
D
V
W
T
V
A
E
I
Q
A
L
K
Q
S
V
E
Q
E
G
L
A
L
L
G
I
E
S
V
A
I
H
---
D
A
I
K
-----
A
-
G
---
T
D
Q
R
D
H
Y
I
D
N
Y
R
Q
T
L
R
N
L
G
K
C
G
I
S
L
V
C
Y
S
F
K
P
I
F
G
W
A
K
T
D
L
A
Y
E
N
E
D
G
S
L
S
L
L
F
D
------------------------------
Q
A
V
V
E
N
M
Q
P
---------
E
D
M
Y
Q
L
I
H
S-------------
W
E
E
-
E
R
L
Q
Q
F
Q
E
L
K
A
M
Y
-
A
G
-
V
T
E
E
D
L
V
E
N
L
R
Y
F
L
E
R
V
I
P
V
C
E
E
E
N
I
K
M
G
I
H
P
D
D
P
P
W
E
I
F
G
L
P
R
I
T
K
N
L
A
D
L
K
R
I
L
S
L
V
D
S
P
A
N
G
I
T
F
C
T
G
S
L
G
A
D
P
T
N
D
L
P
T
M
I
R
E
I
G
--
H
--
R
I
N
F
V
H
F
R
N
V
K
Y
L
G
E
-----
H
-
R
--------------
F
E
E
T
A
H
P
S
--
V
A
G
S
L
D
M
A
E
L
M
Q
A
L
----
V
D
V
G
Y
E
G
V
-----
I
R
P
D
H
G
R
A
I
W
D
-
E
-
K
A
----------
M
---
P
G
Y
---
G
L
Y
D
R
A
M
G
L
T
Y
I
Q
G
L
Y
E
A
T
K
A
K
--
37
HHSearch
56.44
15%
-89
* C2 *
3VNI
1
?
A:
[18-290]
-----------
D
Y
K
Y
Y
I
E
K
V
A
K
L
-
G
F
D
I
L
E
I
A
A
S
P
L
---
P
F
Y
S
D
I
Q
I
N
E
L
K
A
C
A
H
G
N
G
I
T
L
T
V
G
H
G
P
S
A
E
---
Q
N
L
S
-----
S
P
D
---
P
D
I
R
K
N
A
K
A
F
Y
T
D
L
L
K
R
L
Y
K
L
D
V
H
L
I
G
G
A
L
Y
S
Y
W
P
I
---------------------------------------------------------------------------------------
D
Y
----------------
T
-
K
T
-
I
D
K
K
G
D
W
E
R
S
V
E
S
V
R
E
V
A
K
V
A
E
A
C
G
V
D
F
C
L
E
V
L
N
R
F
E
-----
N
Y
L
I
N
T
A
Q
E
G
V
D
F
V
K
Q
V
D
H
N
N
V
K
V
M
L
D
T
F
H
M
N
I
E
E
-
D
S
I
G
G
A
I
R
T
A
G
--
S
--
Y
L
G
H
L
H
T
G
E
C
N
R
K
------------------------------
V
P
G
--
R
G
R
I
P
W
V
E
I
G
E
A
L
----
A
D
I
G
Y
N
G
S
-----
V
V
M
E
P
F
V
R
M
G
G
-
T
-
V
G
S
N
I
KVWRDIS
N
---
G
A
D
E
K
M
L
D
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
C
------
40
HHSearch
54.65
16%
-78
- C2 -
3CNY
2
IOLE_LACPL
A:
[32-300]
-----------
N
L
Q
Q
L
L
S
D
I
V
V
A
-
G
F
Q
G
T
E
V
G
G
F
F
-
P
--------
G
P
E
K
L
N
Y
E
L
K
L
R
N
L
E
I
A
G
Q
W
F
S
S
-
Y
-----
I
------
I
-----
R
D
G
I
E
K
A
S
E
A
F
E
K
H
C
Q
Y
L
K
A
I
N
A
P
V
A
V
V
S
E
Q
T
-
Y
T
I
Q
R
S
D
----------
T
------------------------------------------------------------------------
A
N
I
-----
F
--------
K
D
-
K
P
-
Y
F
T
D
K
E
W
D
E
V
C
K
G
L
N
H
Y
G
E
I
A
A
K
Y
G
L
K
V
A
Y
H
H
H
M
G
--------
T
G
I
Q
T
K
E
E
T
D
R
L
M
A
N
T
D
P
K
L
V
G
L
L
Y
D
T
G
H
I
A
V
S
D
-
G
D
Y
M
A
L
L
N
A
H
I
--
D
--
R
V
V
H
V
H
F
K
D
V
R
R
S
K
E
-----
E
-
E
C
R
A
K
GLT
F
Q
G
S
F
L
N
G
--
M
F
T
V
P
G
--
D
G
D
L
D
F
K
P
V
Y
D
K
L
----
I
A
N
N
Y
K
G
W
-----
I
V
V
E
A
E
Q
D
P
S
K
-------------------
A
N
----
P
L
E
M
A
Q
I
A
H
R
Y
I
K
Q
H
L
I
E
N
-----
39
HHSearch
54.28
17%
-64
- C2 -
3QC0
12
?
A:
[19-274]
-----------
G
F
A
E
A
V
D
I
C
L
K
H
-
G
I
T
A
I
A
P
W
R
D
Q
------
V
A
A
I
G
L
G
E
A
G
R
I
V
R
A
N
G
L
K
L
T
G
L
C
R
G
--
G
---
F
F
P
A
-----
P
-
D
---
A
S
G
R
E
K
A
I
D
D
N
R
R
A
V
D
E
A
A
E
L
G
A
D
C
L
V
L
V
A
G
G
----
L
--------------------------------------------------------------------------------------
P
-----------------
G
-
G
S
-
K
N
I
D
A
A
R
R
M
V
V
E
G
I
A
A
V
L
P
H
A
R
A
A
G
V
P
L
A
I
E
P
L
H
P
M
Y
A
--
A
D
R
A
C
V
N
T
L
G
Q
A
L
D
I
C
E
T
L
G
-
P
G
V
G
V
A
I
D
V
Y
H
V
W
W
D
P
--
D
L
A
N
Q
I
A
R
A
G
--
K
M
K
A
I
L
A
H
H
I
C
D
W
L
V
P
T
K
-----
D
M
L
--------------
T
--
D
R
G
M
M
G
--
D
G
V
I
D
L
K
G
I
R
R
R
I
----
E
A
A
G
F
H
G
A
-----
Q
E
V
E
I
F
S
A
D
N
W
---
W
K
----------
R
---
P
-----
A
D
E
V
I
A
T
C
V
E
R
Y
R
N
C
C
--------
35
HHSearch
53.94
17%
-70
- C2 -
3TVA
4
?
A:
[21-289]
---------
A
-
G
L
G
V
H
L
E
V
A
Q
D
L
-
K
V
P
T
V
Q
V
H
A
P
H
---
P
H
T
R
T
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
V
I
F
G
G
F
D
G
ESY
A
D
I
P
T
T
A
R
T
V
-
G
LVP
L
E
T
R
A
S
R
V
A
E
M
K
E
I
S
D
F
A
S
W
V
G
C
P
A
I
G
L
H
I
G
F
----
V
--------------------------------------------------------------------------------------
P
-------------------
E
---
S
S
S
P
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
------------
E
S
A
D
H
L
L
E
F
I
E
D
V
N
R
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
G
N
P
I
E
A
L
R
K
V
A
--
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
P
V
NERGK
S
-
W
--------------
G
--
Q
E
V
A
L
G
--
T
G
D
V
G
M
E
A
Y
L
T
T
L
----
W
E
I
G
Y
R
G
P
-----
L
T
I
E
R
E
I
P
H
D
--------------------
P
V
Q
---
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
N
C
--