@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0747: (2015-12-02 )
MIKLVATDMDGTFLDENGTYDKKRLANVLKKFKEQGIVFTAASGRSLLSLEQLFADFRDQMAFIAENGSAAVLFNRLAYEQHLSREQYLDIIDHLSKSPYMENNEYVLSGKDGAYILSDANPDYIEFITHYYDNLQKVSHFEDVDDIIFKVTANFTEETVRQAEEWVNQAIPYTTAVTTGFKSIDIILSSVNKRNGLEHLCEQYGIRAEEVLSFGDNINDLEMLEWSGKAIATENARPEVKEIADCIIGHHNNQAVMAYLESMVD
Atome Classification :
(20 SA)
.........10.....-.-.-.20.......----..30........40........---50.....-.--.----.60---.....-...70.----..--.---.-...80........90..--.-.-..-----..---100--...-.-----...-110....------.-------..120--------.-------------...-.-.-.---------130-.----.---------------------.-..-.-.--140.-.---.--..--..150...------------.-...160......-..170-.-....-----...180.-......190.......200.......210.......220.......230.......240....--...-250.......260...----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
L
V
A
TDMD
G
T
FLDE-N-G-TY-
D
K
K
R
L
A
N
----
V
L
K
K
F
K
EQ
G
I
V
F
T
AASGR
S
L
L
S
---
L
E
Q
L
F
A
D
-
F
--
R
----
D
Q
M
---
A
F
I
AE-NGS
A
A
V
----
L
F
--
N
---
R
-
L
A
Y
E
Q
HL
S
R
E
Q
Y
L
D
I
I
D
--
H
-L-SK-----SP---YME--NN
E
-
Y
-----
V
L
S-GKD
G
A
Y
I
------L-------SDAN
P
--------
D
-------------
Y
I
E
-
F
-
I
-
T
---------
H
Y
Y
-
D
----
N
---------------------
L
-
Q
K
-
V
-
S
--
H
F
E
D
-
V
---
D
--
D
I
--
I
F
K
V
TAN
F
------------
T
-
E
E
T
V
R
-
Q
A
E
E
W
V
-
N
QA-I-P-Y
T
T
A-----VTTG
F
K
S
-
I
D
I
I
L
S
S
VNKRN
G
L
E
H
L
C
E
Q
YGI
R
A
E
E
V
L
S
FGDNIN
D
L
E
MLEWSG
K
A
I
ATENAR
P
E
V
K
E
I
A
D
C
--
I
IG-HHN
N
Q
A
V
M
A
Y
L
E
S
MVD----
2
PsiBlast_PDB
96.62
27%
-100
- C2 -
1RLT
3
SUPH_ECOLI
A:
[3-264]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
----
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
---
L
I
S
F
F
P
E
-
L
--
K
----
D
E
I
---
S
F
V
A
E
-
N
G
A
L
V
Y
----
E
H
--
G
---
K
-
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
--
E
-
L
-
L
K
-----
D
K
---
Q
L
-----
N
-
F
-----
V
A
C
-
G
L
Q
S
A
Y
V
------
S
-------
E
N
A
P
E
--------
A
-------------
F
V
A
-
L
-
M
-
A
---------
K
H
Y
-
H
----
R
---------------------
L
-
K
P
-
V
-
K
--
D
Y
Q
E
-
I
---
D
--
D
V
--
L
F
K
F
S
L
N
L
------------
P
-
D
E
Q
I
P
-
L
V
I
D
K
L
-
H
V
A
-
L
D
G
-
I
M
K
P
-----
V
T
S
G
F
G
F
-
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
----
1
PsiBlast_PDB
96.19
27%
-99
- C2 -
1RLM
3
SUPH_ECOLI
A:
[3-264]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
----
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
---
L
I
S
F
F
P
E
-
L
--
K
----
D
E
I
---
S
F
V
A
E
-
N
G
A
L
V
Y
----
E
H
--
G
---
K
-
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
--
E
-
L
-
L
K
-----
D
K
---
Q
L
-----
N
-
F
-----
V
A
C
-
G
L
Q
S
A
Y
V
------
S
-------
E
N
A
P
E
--------
A
-------------
F
V
A
-
L
-
M
-
A
---------
K
H
Y
-
H
----
R
---------------------
L
-
K
P
-
V
-
K
--
D
Y
Q
E
-
I
---
D
--
D
V
--
L
F
K
F
S
L
N
L
------------
P
-
D
E
Q
I
P
-
L
V
I
D
K
L
-
H
V
A
-
L
D
G
-
I
M
K
P
-----
V
T
S
G
F
G
F
-
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
----
49
HHSearch
95.28
28%
-89
- C2 -
1RLM
3
SUPH_ECOLI
A:
[2-264]
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
N
Q
P
R
F
-
M
A
----
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
---
L
I
S
F
F
P
E
-
L
--
K
----
D
E
I
---
S
F
V
A
E
-
N
G
A
L
V
Y
----
E
H
--
G
---
K
-
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
--
E
L
L
-
K
D
-----
K
---------
Q
L
N
-
F
-----
V
A
C
-
G
L
Q
S
A
Y
V
------
S
-------
E
N
A
P
E
--------
A
-------------
F
V
A
-
L
-
M
-
A
---------
K
H
Y
-
H
----
R
---------------------
L
-
K
P
-
V
-
K
--
D
Y
Q
E
-
I
---
D
--
D
V
--
L
F
K
F
S
L
N
L
------------
P
-
D
E
Q
I
P
-
L
V
I
D
K
L
-
H
V
A
-
L
-
D
G
I
M
K
P
-----
V
T
S
G
F
G
F
-
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
----
51
HHSearch
90.36
27%
-84
- C2 -
3L7Y
1
?
A:
[36-300]
S
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
-
K
-
G
-
S
Y
D
H
N
R
F
-
Q
R
----
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
P
Y
R
Q
---
L
R
E
H
F
P
D
-
C
--
H
----
E
Q
L
---
T
F
V
G
E
-
N
G
A
N
I
I
----
S
K
--
N
---
Q
-
S
L
I
E
V
F
Q
Q
R
E
D
I
A
S
I
I
Y
--
F
-
I
-
E
E
-----
K
Y
---
P
----
Q
A
V
-
I
-----
A
L
S
-
G
E
K
K
G
Y
L
------
K
-------
K
G
V
S
E
--------
N
-------------
I
V
K
-
M
-
L
-
S
---------
P
F
F
-
P
----
V
---------------------
L
-
E
L
-
V
-
N
--
S
F
S
P
-
L
---
P
--
E
R
--
F
F
K
L
T
L
Q
V
------------
K
-
E
E
E
S
A
-
Q
I
M
K
A
I
-
A
D
Y
-
K
T
S
Q
R
L
V
G
-----
T
A
S
G
F
G
Y
-
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
--
Q
A
K
-
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
----
4
PsiBlast_PDB
86.71
30%
-84
- C2 -
3L7Y
1
?
A:
[37-281]
-
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
-
K
-
G
-
S
Y
-
D
H
N
R
F
Q
R
----
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
P
Y
R
Q
---
L
R
E
H
F
P
D
-
C
--
H
----
E
Q
L
---
T
F
V
G
E
-
N
G
A
N
I
I
----
S
K
--
N
---
Q
-
S
L
I
E
V
F
Q
Q
R
E
D
I
A
S
I
I
-------------------
Y
F
I
--
E
E
K
-
Y
PQ
A
V
I
A
L
S
-
G
E
K
K
G
Y
L
------
K
-------
K
G
V
S
E
--------
N
-------------
I
V
K
-
M
-
L
-
S
---------
P
F
F
-
P
----
V
---------------------
L
-
E
L
-
V
-
N
--
S
F
S
P
-
L
P-----
E
R
--
F
F
K
L
T
L
Q
V
------------
K
-
E
E
E
S
A
-
Q
----
I
-
M
K
A
-
I
-
A
D
Y
K
T
S
QR
L
V
G
T
A
S
G
F
G
Y
-
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
--
Q
A
K
-
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
----
57
HHSearch
84.18
26%
-84
- C2 -
1NF2
3
?
A:
[1-262]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
D
-
N
-
L
-
E
I
-
S
E
K
D
-
R
R
----
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
---
T
L
N
V
E
K
K
Y
F
--
K
----
R
T
F
---
P
T
I
A
Y
-
N
G
A
I
V
Y
----
L
P
--
E
E--
G
-
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
--
Y
-
I
-
K
P
-----
L
---------
N
V
H
-
W
-----
Q
A
Y
-
I
D
D
V
L
Y
S
------
E
-------
K
D
N
E
E
-----------------------
I
------
K
---------
S
Y
A
-
R
H
S
N
V
D
---------------------
Y
-
R
V
-
E
-
P
--
N
L
S
E
-
L
---
V
S
K
M
G
--
T
T
K
L
L
L
I
D
------------
T
-
P
E
R
L
D
-
E
L
K
E
I
L
-
S
E
R
-
F
-
K
D
V
V
K
V
-----
F
K
S
F
P
T
Y
-
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
--
V
T
L
-
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
----
50
HHSearch
82.94
24%
-81
- C2 -
3DAO
1
?
A:
[20-283]
M
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
-
G
-
S
L
L
I
-
D
P
E
Y
-
M
S
----
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
Q
F
S
S
---
E
F
K
L
F
A
P
-
I
--
K
----
H
K
L
---
L
Y
I
T
D
-
G
G
T
V
V
R
----
T
P
--
K
---
E
-
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
M
C
R
--
M
-
V
-
R
D
-----
E
L
---
P
----
A
C
D
-
Y
-----
F
A
A
-
T
P
D
F
C
F
A
------
E
-------
D
G
G
S
P
----------------------
I
F
H
-
L
-
L
R
D
---------
S
Y
G
-
F
----
E
---------------------
M
-
R
E
-
V
-
D
--
D
I
T
R
-
L
---
D
R-
N
D
--
I
I
K
F
T
V
F
H
------------
P
-
D
K
-
C
E
-
E
L
C
T
P
V
F
I
P
A
-
W
-
N
K
K
A
H
L
-----
A
A
A
G
K
E
W
-
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
--
T
C
A
-
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-----
67
Fugue
82.33
25%
-83
- C2 -
1NF2
3
?
A:
[1-267]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
D
-
N
-
L
-
E
I
-
S
-
E
K
D
R
R
----
N
I
E
K
L
S
-
R
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
---
T
L
N
V
E
K
K
-
Y
F
-
K
----
R
T
F
---
P
T
I
A
Y
-
N
G
A
I
V
Y
----
L
P
--
E
E--
G
-
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
--
Y
-
I
-
K
P
-----
L
N
V
H
W
Q
A
Y
--
I
D
D
-
V
-----
L
Y
S
-
E
K
D
N
E
E
I
------
K
-------
S
Y
A
R
H
--------
S
-------------
N
V
D
-
Y
-
R
-
V
---------
E
---
P
----
N
---------------------
L
-
S
E
-
L
-
V
--
S
K
M
G
-
T
---
T
--
K
L
--
L
L
I
D
T
P
E
R
------------
L
-
D
E
L
K
E
-
I
L
S
E
R
F
-
K
D
V
-
V
-
K
-
V
F
K
S
-----
F
P
T
---
Y
-
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
--
V
T
L
-
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
DCLD
7
PsiBlast_PDB
80.81
25%
-65
- C2 -
2QYH
5
?
A:
[4-254]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
E
-
Q
-
K
-
Q
L
-
P
L
S
T
I
E
A
----
V
-
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
---
F
E
H
V
-------
R
----
K
Q
L
GID
S
F
V
S
F
-
N
G
Q
Y
V
V
----
F
E
--
G
---
N
-
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
H
-
K
-
N
G
-----
H
P
L
V
-
F
M
D
--
A
E
K
-
M
-----
R
A
S
-
I
G
D
H
P
H
I
H
V
S
M
A
S
L
-------
K
F
A
H
P
--------
P
-------------
V
D
P
-
L
--------------
Y
Y
-
E
----
N
---------------------------------
K
D
-
I
---
Y
--
Q
A
--
L
L
F
C
R
A
E
E
------------
E
-
E
P
Y
V
R
-
N
Y
P
E
F
------------
R
F
-----
V
R
W
H
D
V
S
-
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
--
V
T
K
-
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
----
8
PsiBlast_PDB
80.70
27%
-72
- C2 -
1NF2
3
?
A:
[1-261]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
----
I
E
K
L
S
R
K
C
Y
V
V
F
--
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
Y
---
F
--
K
----
R
T
F
---
P
T
I
A
Y
-
N
G
A
I
V
Y
----
L
P
--
E
---
E
G
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
--
Y
-
I
-
K
P
LN
V
H
W
Q
A
---
Y
I
D
--
D
V
L
-
Y
-------
S
-
E
K
D
N
E
E
I
------
K
-------
S
Y
A
R
H
--------
S
-------------
N
V
D
-
Y
-
R
-
V
---------
E
---
P
----
N
---------------------
L
-
S
E
L
V
-
S
--
K
M
G
T
-
T
---
K
--
L
L
--
L
I
D
-----------------
T
-
P
E
R
L
D
-
E
L
K
E
I
L
-
S
E
R
-
F
-
K
-
D
V
V
K
-----
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
--
V
T
L
-
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
----
52
HHSearch
79.73
22%
-78
- C2 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
-
E
N
----
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
---
V
M
S
I
F
E
P
-
L
--
G
----
I
K
T
---
W
V
I
S
A
-
N
G
A
V
I
H
----
D
P
E-
G
---
R
-
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
--
W
-
L
-
E
S
-----
E
---------
N
Y
Y
-
Y
-----
E
V
F
-
T
G
S
A
I
Y
T
------
P
-------
Q
N
G
R
E
----------------------
L
L
D
-
V
E
L
-
D
---------
R
F
R
-
S
----
A
NPEAD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
SG
F
-
A
Y
-
I
-
N
--
S
F
Q
E
-
L
FEA
D
E
P
I
D
--
F
Y
N
I
L
G
F
S
F-----------
F
-
K
E
K
L
E
-
A
G
W
K
R
Y
-
E
-
H
-
A
-
E
-
D
L
T
L
-----
V
S
S
A
E
H
N
-
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L
-
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
54
HHSearch
79.51
23%
-72
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[4-270]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
-
D
-
H
-
T
I
-
S
P
A
V
-
K
N
----
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
---
V
H
N
Y
L
K
E
-
L
--
H
MEQ-
P
G
D
---
Y
C
I
T
Y
-
N
G
A
L
V
Q
----
K
A
AD
G
---
S
-
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
--
L
-
S
-
R
E
-----
V
---------
G
S
H
-
F
-----
H
A
L
-
D
R
T
T
L
Y
T
------
A
-------
N
R
D
I
S
----------------------
Y
Y
T
-
V
-
H
-
E
---------
S
F
V
-
A
----
T
---------------------
I
-
P
L
-
V
F
C
--
E
A
E
K
-
M
---
D
PN
T
Q
--
F
L
K
V
M
M
I
D
------------
E
-
P
A
I
L
D
-
Q
A
I
A
R
I
-
P
Q
E
-
V
-
K
E
K
Y
T
V
-----
L
K
S
A
P
Y
F
-
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
--
V
T
K
-
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
----
5
PsiBlast_PDB
79.43
24%
-61
- C2 -
3DAO
1
?
A:
[21-283]
-
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
-
G
-
S
-
L
L
-
I
D
P
E
Y
M
S
----
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
Q
F
S
S
---
E
F
K
L
F
A
P
-
I
--
K
----
H
K
L
---
L
Y
I
T
D
-
G
G
T
V
V
R
T
PKE
I
L
--
K
---
T
-
Y
P
M
D
E
D
I
W
K
G
M
C
R
M
V
R
D
--
E
-
L
-
P
A
-----
C
D
---
Y
F
A
--
A
T
P
-
D
-----
F
C
F
-
A
E
D
G
G
S
P
------
I
-------
F
H
L
L
R
--------
D
-------------
S
Y
G
-
F
-
E
-
M
---------
R
E
V
-
D
----
D
---------------------
I
-
T
R
-
L
-------
D
-
R
---
N
--
D
I
--
I
-----
K
F
------------
T
-
V
F
H
P
D
-
K
C
E
E
L
C
-
T
P
V
F
I
-
P
-
A
W
N
K
K
A
H
L
-
A
A
A
G
K
E
W
-
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
--
T
C
A
-
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-----
56
HHSearch
77.20
22%
-72
- C2 -
3PGV
9
?
A:
[21-283]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
P
-
D
-
H
-
F
L
-
T
P
Y
A
-
K
E
----
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
---
V
G
Q
I
R
D
N
-
L
--
G
----
I
R
S
---
Y
M
I
T
S
-
N
G
A
R
V
H
----
D
S
D-
G
---
Q
-
Q
I
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
--
I
-
V
-
R
N
-----
D
P
--------
K
I
V
-
T
-----
N
V
Y
-
R
E
D
E
W
Y
M
------
N
-------
R
H
R
------------------------------------------
F
F
K
-
E
----
A
---------------------
V
-
F
N
-
Y
-
K
L
Y
E
P
G
E
-
L
---
D
P-
Q
G
--
I
S
K
V
F
F
T
C
------------
E
D
H
E
H
L
L
-
P
L
E
Q
A
M
-
N
A
R
-
W
-
G
D
R
V
N
V
-----
S
F
S
T
L
T
C
-
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
V
I
G
-
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
----
55
HHSearch
75.84
20%
-77
- C2 -
3DNP
1
YHAX_BACSU
A:
[6-274]
-
K
Q
L
L
A
L
N
I
D
G
A
L
L
R
S
-
N
-
G
-
K
I
-
H
Q
A
T
-
K
D
----
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
---
A
Q
K
I
A
K
S
-
L
--
K
----
L
D
A
---
K
L
I
T
H
-
S
G
A
Y
I
A
----
E
K
--
I
D--
A
-
P
F
F
E
K
R
I
S
D
D
H
T
F
N
I
V
Q
--
V
-
L
-
E
S
-----
Y
---------
Q
C
N
-
I
-----
R
L
L
-
H
--
E
K
Y
S
------
I
-------
G
N
K
K
K
VNS
N
L
L
G
K
A
-------------
L
I
H
P
S
-
D
-
P
---------
I
F
Y
-
P
----
V
-----------------------
Q
F
-
V
-
E
--
S
L
S
D
-
L
---
L
MD
E
P
VS
A
P
V
I
E
V
Y
T
------------
E
-
H
D
I
Q
H
-
D
I
T
E
T
I
-
T
K
A
-
F
-
P
-
A
V
D
V
-----
I
R
V
N
D
E
K
-
L
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
W
--
V
T
R
-
S
N
D
E
Q
G
V
A
Y
M
M
K
E
Y
F
R
----
10
PsiBlast_PDB
75.42
23%
-60
- C2 -
1NRW
2
YWPJ_BACSU
A:
[5-271]
--
K
L
I
A
I
D
L
D
G
T
L
L
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
-
E
N
----
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
---
V
M
S
I
F
E
P
-
L
--
G
----
I
K
T
---
W
V
I
S
A
-
N
G
--
A
V
----
I
H
--
D
PEG
R
-
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
--
W
-
L
E
S
E
-----
N
Y
---
Y
Y
E
V
F
T
G
S
-
A
-----
I
Y
T
-
P
Q
N
G
R
E
L
------
L
D
V
E
L
D
R
F
R
S
A
N
P
--------
E
AD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
-
S
-
G
-
F
---------
A
Y
I
-
N
----
S
---------------------
F
-
Q
E
-
L
-
F
--
E
A
D
E
-
P
---
I
--
D
F
--
Y
N
I
L
G
F
S
F
------------
F
-
K
E
K
L
E
-
A
G
W
K
R
Y
-
E
H
A
-
E
-
D
-
L
T
L
------
V
S
S
A
E
H
N
-
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L
-
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
59
HHSearch
75.08
22%
-69
* C2 *
3R4C
4
?
A:
[11-266]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
-
E
T
H
-
K
V
-
S
Q
S
S
-
I
D
----
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
---
L
H
E
I
D
A
--
V
-------
P
Y
D
---
G
V
I
A
L
-
N
G
A
E
C
V
----
L
R
D-
G
---
S
-
V
I
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
--
L
-
A
-
R
E
-----
F
---------
D
F
A
-
V
-----
A
L
E
-
L
N
E
G
V
F
V
------
N
-------
R
L
T
P
T
-----------------------
V
E
-
Q
-
I
-
A
---------
G
I
V
E
H
----
P
---------------------
V
-
P
P
-
V
-
V
--
D
I
E
E
-
M
---
F
E
R
K
E
--
C
C
Q
L
C
F
Y
F
------------
D
-
E
E
A
E
Q
-
K
V
M
P
L
L
-------
S
-
G
L
S
A
-----
T
R
W
H
P
L
F
-
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
--
V
T
D
-
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
V
----
47
HHSearch
74.08
18%
-80
- C2 -
3FZQ
7
?
A:
[4-271]
L
Y
K
L
L
I
L
D
I
D
G
T
L
R
D
E
-
V
-
Y
-
G
I
-
P
E
S
A
-
K
H
----
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
---
I
Q
D
D
V
L
S
-
L
--
G
----
V
-
D
---
G
Y
I
A
G
-
G
G
N
Y
I
Q
----
Y
H
--
G
---
E
-
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
--
L
-
L
-
K
K
-----
R
---------
E
V
A
-
F
-----
S
I
E
-
S
Q
E
K
V
F
M
------
N
-------
Q
K
A
K
E
I
F
------
E
-------------
T
M
N
-
Q
-
L
-
K
GTNSCINKQ
H
I
Q
-
E
----
K
---------------------
I
-
T
Y
-
E
-
N
--
N
I
E
E
-
Y
---
K
S-
Q
D
--
I
H
K
I
C
L
W
S
------------
N
-
E
K
V
F
D
-
E
V
K
D
I
L
-
Q
D
K
-
M
-
E
--
L
A
Q
-----
R
D
I
S
S
Q
Y
-
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
--
I
C
E
-
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
N
I
----
12
PsiBlast_PDB
74.08
24%
-69
- C2 -
4DW8
4
?
A:
[6-268]
--
K
L
I
V
L
D
L
D
G
T
L
--------
T
N
-
S
K
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
---
I
V
P
L
A
N
E
-
L
--
R
MN--
E
F
G
---
G
F
I
L
S
Y
N
G
G
E
I
I
----
N
W
ES
K
---
E
-
M
M
Y
E
N
V
L
P
N
E
-
V
V
P
V
L
Y
--
E
-
C
-
A
R
-----
T
N
---
H
L
S
--
I
L
T
-
Y
-----------
D
G
A
E
I
------
V
-------
T
E
N
S
L
--------
D
P
------------
Y
V
Q
-----
K
---------
E
A
F
-
L
----
N
---------------------
K
-
M
A
-
I
-
R
--
E
T
N
D
F
L
---
T
--
D
I
--
T
L
P
V
A
K
C
L
I
V
G
D
A
G
K
L
I
P
V
E
S
-
E
L
C
I
R
L
Q
G
K
I
N
V
-
F
R
S
-
E
-
P
-
Y
F
---------------
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
--
I
T
L
-
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----
53
HHSearch
73.45
22%
-70
- C2 -
2B30
2
?
A:
[26-298]
D
I
K
L
L
L
I
D
F
D
G
T
L
F
V
D
K
D
-
I
-
K
V
-
P
S
E
N
-
I
D
----
A
I
K
E
A
I
E
K
G
Y
M
V
S
I
C
T
G
R
S
K
V
G
---
I
L
S
A
F
G
E
-
E
N
L
K
K
M
NF
Y
G
M
---
P
G
V
Y
I
-
N
G
T
I
V
Y
----
D
Q
I-
G
---
Y
-
T
L
L
D
E
T
I
E
T
D
V
Y
A
E
L
I
S
--
Y
-
L
-
V
E
-----
K
---------
N
L
V
N
Q
-----
T
I
F
H
R
G
E
S
N
Y
V
------
T
-------
E
D
N
K
-----------------------
Y
A
D
-
F
-
L
-
Q
---------
K
M
Y
-
S
----
E
---------------------
N
R
S
I
-
I
I
R
--
H
N
E
M
-
L
---
K
Y-
R
T
--
M
N
K
L
M
I
V
L
------------
D
-
P
S
E
S
K
-
T
V
I
G
N
L
-
K
Q
K
-
F
-
K
N
K
L
T
I
-----
F
T
T
Y
N
G
H
-
A
E
V
T
K
L
G
H
D
K
Y
T
G
I
N
Y
L
L
K
H
Y
N
I
S
N
D
Q
V
L
V
V
G
D
A
E
N
D
I
A
M
L
S
N
F
K
Y
S
F
A
V
A
N
A
T
D
S
A
K
S
H
A
K
C
--
V
L
P
V
S
H
R
E
G
A
V
A
Y
L
L
K
K
V
F
D
----