@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0766: (2015-12-03 )
MNQNHSVKRSLSEVNQSVEVPHNSSFWNTLRAFLGPGALVAVGYMDPGNWITSVIGGATYRYLLLFVVLVSSLMAMQLQQMAGKLGIVTRQDLAQATASRLPKPLRYLLFIIIELALIATDLAEVIGSAIALHLLFGWPLLLSIMITILDVFLLLLLMKLGVQKIEAFVSVLILTILIIFTYLVVLSQPDLDAMFKGFLPHHELFNISHEGKNSPLTLALGIIGATVMPHNLYLHSSLSQTRRVDYHNKSSIKKAVRFMTLDSNIQLSLAFVVNSLLLVLGASLFYGHANDISAFSQMYLALSDKTITGAVASSFLSTLFAVALLASGQNSTITGTLTGQIVMEGFLHFKLPQWLIRLCTRLLTLLPIFVIALLVGGEENTLDQLIVYSQVFLSLALPFSIFPLIYFTSQKSIMGEHANAKWNTYLAYLVAIILTLLNLKLIMDLL
Atome Classification :
(19 SA)
-------------------------------------------.........10........20-.........30....-.----.-----..40........---50......------..60...---.....70.----....-...80-----------........90---.........100.......-110..-..--------...120-.......130......-----.140---------------------...--....--------------..150....-----------.-..160.--...---..------..------------.170.......180...-....----190....----..--.200-----.----------...----...---210.......-220----...--...--.--------.230--.--------------..-......240------.......250---........260-...--.....----.270...---....280.....-..290.......300..-..--..------------.310--..-..--------------....320---.......-330...-----...---.340----------....-...350----....--...----------.360.......370..---.-....380......-.390...-....400-------...-------....410..-....---------.420-....------...430.......440....----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------MNQ
N
H
S
V
K
R
S
L
S
E
V
N
Q
SVEV--PHNS
S
F
W
N
T
L
R
A
FLG-P----
G
-----
A
L
V
A
V
G
YMDP
G
N
---
W
I
T
S
V
IG
G
------
A
T
Y
R
Y
L
L
---
L
F
V
V
L
V
S
S
----
L
M
A
M
-
Q
L
Q
Q
M
-----------
A
G
KLGI
V
T
R
----
Q
D
L
A
Q
A
T
A
S
RL
P
K
P
L
R
Y
L
L
-
F
I
I
I
E
-
L
A
--------
L
I
A
T
D
L
-
A
E
V
I
G
S
A
I
A
L
H
L
L
FG
W
-----
P
L
-----------------------
L
L
S
--
I
M
I
T
--------------
I
L
D
V
F
L
L
L
L
-----------
L
-
M
K
L
--
G
--
V
Q
K
---
I
E
------
A
F
------------
V
S
V
L
I
L
T
I
L
I
I
F
T
Y
L
V
V-LSQP----
D
L
D
A
M
F
K
----
G
F--LP
H
H
-----
E
----------
L
FN----ISH---EGKNS
P
L
T
L
A
-
L
G
-----
I
IG--ATV--M--------P
H
----
N
--------------
L
Y
-
L
HSSLSQ
T
R
------
R
VDYH
N
K
S
S
----
I
K
K
A
V
R
F
M
T---LDS--N
I
Q
L
S
----
L
A
F
V
V
N
S
---
L
L
L
V
L
G
A
S
L
FYG-HA
N
D
I
S
A
F
S
Q
M
Y
L
ALSD-KT--
I
T
------------
G
A
V
---
A
S
-
S
F
--------------
L
S
T
L
F
A
V
---
A
L
L
ASGQ-N
S
T
I
T
G
-----
T
L
T
---
G
Q
I
V
----------
M
E
G
F
-LHFK
L
-----
P
Q
W
L
--
I
R
L
----------
C
T
R
L
L
T
L
L
P
I
F
V
I
A
L
L
---V-GGEE
N
T
L
D
Q
L
I
V
Y
-
S
Q
V
F
L
S
L-AL
P
F
S
I
F
-------
P
L
I
-------
Y
FTS
Q
K
S
I
M
-
G
EHA---------NA
K
W
-
N
T
Y
L
------
A
Y
L
V
A
I
I
L
T
L
L
N
L
K
L
I
M
DLL----------------------------------------------------------------------------------------------------------
13
Fugue
99.74
54%
-148
* C8 *
4WGV
-
?
A:
[5-399]
------------------------------------------------------------------------------------------------
V
G
Y
M
D
P
G
N
---
W
I
T
S
M
Q
G
G
------
A
Q
Y
G
Y
T
L
---
L
F
V
I
L
I
S
S
----
L
A
A
M
-
L
L
Q
S
M
-----------
T
V
R
L
G
I
A
T
G
----
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
-
L
A
--------
I
I
A
T
D
I
-
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
I
-----
P
L
-----------------------
I
V
G
--
A
L
I
T
--------------
V
F
D
V
F
L
L
L
F
-----------
I
-
M
R
F
--
G
--
F
R
K
---
I
E
------
A
I
------------
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
-
I
S
S
P
----
Q
L
T
D
I
L
N
----
G
F
--
V
P
H
K
-----
E
----------
I
V
T
------------
N
Q
G
I
L
Y
I
A
-
L
G
-----
I
I
G
--
A
T
I
--
M
--------
P
H
----
N
--------------
L
Y
-
L
H
S
S
I
V
Q
S
R
------
K
Y
D
R
H
D
N
E
E
----
K
A
Q
A
I
K
Y
A
T
---
I
D
S
--
N
L
Q
L
S
----
I
A
F
V
V
N
C
---
L
L
L
T
L
G
A
A
L
F
F
G
T
K
T
N
D
L
G
G
F
Y
D
L
Y
H
A
L
K
T
-
E
P
--
V
L
------------
G
A
T
---
L
G
-
G
V
--------------
M
S
T
L
F
A
V
---
A
L
L
A
S
G
Q
-
N
S
T
I
T
G
-----
T
L
A
---
G
Q
I
V
----------
M
E
G
F
-
L
R
L
S
I
-----
P
N
W
L
--
R
R
L
----------
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
I
---
F
-
K
G
N
S
E
K
I
E
Q
L
L
V
F
-
S
Q
V
F
L
S
I
-
A
L
P
F
S
L
I
-------
P
L
Q
-------
L
A
T
S
N
K
K
L
M
-
G
P
F
I
---------
N
K
T
W
-
V
N
I
I
------
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
99.14
54%
-148
- C8 -
4WGW
1
?
A:
[5-399]
------------------------------------------------------------------------------------------------
V
G
Y
M
D
P
G
N
---
W
I
T
S
M
Q
G
G
------
A
Q
Y
G
Y
T
L
---
L
F
V
I
L
I
S
S
----
L
A
A
M
-
L
L
Q
S
M
-----------
T
V
R
L
G
I
A
T
G
----
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
-
L
A
--------
I
I
A
T
D
I
-
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
I
-----
P
L
-----------------------
I
V
G
--
A
L
I
T
--------------
V
F
D
V
F
L
L
L
F
-----------
I
-
M
R
F
--
G
--
F
R
K
---
I
E
------
A
I
------------
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
-
I
S
S
P
----
Q
L
T
D
I
L
N
----
G
F
--
V
P
H
K
-----
E
----------
I
------
V
T
N
---
Q
G
I
---
L
Y
I
A
-
L
G
-----
I
I
G
--
A
T
I
--
M
--------
P
H
----
N
--------------
L
Y
-
L
H
S
S
I
V
Q
S
R
------
K
Y
D
R
H
D
N
E
E
----
K
A
Q
A
I
K
Y
A
T
---
I
D
S
--
N
L
Q
L
S
----
I
A
F
V
V
N
C
---
L
L
L
T
L
G
A
A
L
F
F
G
T
K
T
N
D
L
G
G
F
Y
D
L
Y
H
A
L
K
T
-
E
P
--
V
L
------------
G
A
T
---
L
G
-
G
V
--------------
M
S
T
L
F
A
V
---
A
L
L
A
S
G
Q
-
N
S
T
I
T
G
-----
T
L
A
---
G
Q
I
V
----------
M
E
G
F
-
L
R
L
S
I
-----
P
N
W
L
--
R
R
L
----------
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
I
---
F
-
K
G
N
S
E
K
I
E
Q
L
L
V
F
-
S
Q
V
F
L
S
I
-
A
L
P
F
S
L
I
-------
P
L
Q
-------
L
A
T
S
N
K
K
L
M
-
G
P
F
I
---------
N
K
T
W
-
V
N
I
I
------
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.08
54%
-148
- C8 -
4WGV
-
?
A:
[5-399]
------------------------------------------------------------------------------------------------
V
G
Y
M
D
P
G
N
---
W
I
T
S
M
Q
G
G
------
A
Q
Y
G
Y
T
L
---
L
F
V
I
L
I
S
S
----
L
A
A
M
-
L
L
Q
S
M
-----------
T
V
R
L
G
I
A
T
G
----
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
-
L
A
--------
I
I
A
T
D
I
-
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
I
-----
P
L
-----------------------
I
V
G
--
A
L
I
T
--------------
V
F
D
V
F
L
L
L
F
-----------
I
-
M
R
F
--
G
--
F
R
K
---
I
E
------
A
I
------------
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
-
I
S
S
P
----
Q
L
T
D
I
L
N
----
G
F
--
V
P
H
K
-----
E
----------
I
------
V
T
N
---
Q
G
I
---
L
Y
I
A
-
L
G
-----
I
I
G
--
A
T
I
--
M
--------
P
H
----
N
--------------
L
Y
-
L
H
S
S
I
V
Q
S
R
------
K
Y
D
R
H
D
N
E
E
----
K
A
Q
A
I
K
Y
A
T
---
I
D
S
--
N
L
Q
L
S
----
I
A
F
V
V
N
C
---
L
L
L
T
L
G
A
A
L
F
F
G
T
K
T
N
D
L
G
G
F
Y
D
L
Y
H
A
L
K
T
-
E
P
--
V
L
------------
G
A
T
---
L
G
-
G
V
--------------
M
S
T
L
F
A
V
---
A
L
L
A
S
G
Q
-
N
S
T
I
T
G
-----
T
L
A
---
G
Q
I
V
----------
M
E
G
F
-
L
R
L
S
I
-----
P
N
W
L
--
R
R
L
----------
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
I
---
F
-
K
G
N
S
E
K
I
E
Q
L
L
V
F
-
S
Q
V
F
L
S
I
-
A
L
P
F
S
L
I
-------
P
L
Q
-------
L
A
T
S
N
K
K
L
M
-
G
P
F
I
---------
N
K
T
W
-
V
N
I
I
------
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
----------------------------------------------------------------------------------------------------------------
3
PsiBlast_CBE
98.60
54%
-150
- C8 -
4WGW
1
?
C:
[5-399]
------------------------------------------------------------------------------------------------
V
G
Y
M
D
P
G
N
---
W
I
T
S
M
Q
G
G
------
A
Q
Y
G
Y
T
L
---
L
F
V
I
L
I
S
S
----
L
A
A
M
-
L
L
Q
S
M
-----------
T
V
R
L
G
I
A
T
G
----
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
-
L
A
--------
I
I
A
T
D
I
-
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
I
-----
P
L
-----------------------
I
V
G
--
A
L
I
T
--------------
V
F
D
V
F
L
L
L
F
-----------
I
-
M
R
F
--
G
--
F
R
K
---
I
E
------
A
I
------------
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
-
I
S
S
P
----
Q
L
T
D
I
L
N
----
G
F
--
V
P
H
K
-----
E
----------
I
------
V
T
N
---
Q
G
I
---
L
Y
I
A
-
L
G
-----
I
I
G
--
A
T
I
--
M
--------
P
H
----
N
--------------
L
Y
-
L
H
S
S
I
V
Q
S
R
------
K
Y
D
R
H
D
N
E
E
----
K
A
Q
A
I
K
Y
A
T
---
I
D
S
--
N
L
Q
L
S
----
I
A
F
V
V
N
C
---
L
L
L
T
L
G
A
A
L
F
F
G
T
K
T
N
D
L
G
G
F
Y
D
L
Y
H
A
L
K
T
-
E
P
--
V
L
------------
G
A
T
---
L
G
-
G
V
--------------
M
S
T
L
F
A
V
---
A
L
L
A
S
G
Q
-
N
S
T
I
T
G
-----
T
L
A
---
G
Q
I
V
----------
M
E
G
F
-
L
R
L
S
I
-----
P
N
W
L
--
R
R
L
----------
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
I
---
F
-
K
G
N
S
E
K
I
E
Q
L
L
V
F
-
S
Q
V
F
L
S
I
-
A
L
P
F
S
L
I
-------
P
L
Q
-------
L
A
T
S
N
K
K
L
M
-
G
P
F
I
---------
N
K
T
W
-
V
N
I
I
------
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
----------------------------------------------------------------------------------------------------------------
20
Fugue
64.80
22%
-115
- C5 -
2I3O
-
?
D:
[2-516]
----------------------------------------------
F
R
S
R
P
N
A
L
S
Q
--
R
S
V
I
A
--
S
S
S
E
L
A
S
L
A
G
R
D
I
L
K
-
R
----
G
GNIFD
A
A
L
A
V
S
A
L
C
V
T
Q
---
N
N
L
C
G
L
G
G
------------
D
---
L
F
A
L
I
R
D
E
----
N
G
Q
I
-
D
L
N
G
------------
S
G
Q
A
S
R
A
V
S
----
I
D
Y
Y
E
S
G
L
T
K
I
P
E
R
G
P
Y
A
A
-
I
T
V
P
G
-
I
A
GSWDEIFR
K
F
A
T
D
I
-
A
D
I
L
E
P
A
I
R
T
A
S
A
-
G
F
-----
P
I
-----------------------
T
Q
N
--
Y
S
D
S
--------------
I
A
R
S
A
P
V
I
-----------------------
G
Q
---
Y
R
------
G
W
------------
S
S
--
I
F
P
N
G
S
V
P
V
A
G
E
I
-
L
K
Q
P
----
D
L
A
E
S
F
R
LSEE
G
F
RS
F
Y
D
G
-----
S
----------
L
A
D
----
I
I
I
AGL
E
G
T
G
S
P
L
S
D
R
-
D
L
RVYRP
L
I
G
--
K
P
V
--
F
--------
T
D
LDEF
R
--------------
I
Y
-
E
T
S
P
N
S
Q
G
I
TVIEWI
R
G
E
S
H
G
Y
D
S
RTWE
A
K
I
E
D
I
F
E
T
EEA
Y
D
K
--
R
R
K
I
T
D---
P
S
Y
N
I
A
Q
---
H
D
S
A
N
G
K
G
L
P
K
R
-
D
H
N
D
I
G
--
D
T
T
Y
F
S
I
S
D
-
S
E
GR
S
V
------------
S
I
I
---
Q
S
-
N
Y
GFGSGIVPKGTGFV
L
Q
N
R
G
S
Y
---
F
T
L
Q
R
D
H
-
P
N
A
L
P
G
KRTFH
T
L
A
---
A
C
V
E
----------
K
E
H
D
-
L
Y
A
S
L
GSGGD
I
Q
P
Q
--
V
Q
-------------
Q
I
L
E
I
L
K
---------------
D
N
T
D
P
Q
A
I
L
D
-
K
P
R
W
T
----
E
P
Y
T
I
Y
EAP----
G
A
V
-------
Y
V
E
S
E
E
L
Y
R
-
N
V
S
K
---------
Q
I
S
G
-
R
K
V
V
LRDVSQ
E
F
G
T
A
Q
I
T
T
L
I
R
G
D
V
V
V
G
A
A
DPRGDGIAIPYS----------------------------------------------------------------------------------------------
18
Fugue
62.83
13%
-130
- C7 -
3KHK
1
?
A:
[7-530]
----------------------------------------------------------
Q
Q
F
L
N
--
D
L
D
N
Q
L
W
R
A
A
D
K
L
R
S
-
N
---------------------------
L
D
A
A
N
Y
------
K
H
V
V
L
G
L
---
I
F
L
K
Y
V
S
D
----
A
F
E
E
-
R
Q
Q
E
L
-----------
T
E
L
F
Q
K
D
D
D
DNIY
Y
L
P
R
E
D
Y
D
S
D
E
A
Y
Q
Q
A
I
A
E
-
E
L
E
I
G
-
D
Y
--------
Y
T
E
K
N
V
-
F
W
V
P
K
T
A
R
W
N
K
L
R
D
V
I
-----
T
L
-----------------------
P
T
S
--
V
S
W
L
--------------
I
D
N
A
F
D
D
I
E
-----------
K
-
A
N
P
--
K
--
L
K
G
---
I
L
------
N
R
------------
I
S
Q
Y
Q
L
D
A
D
K
L
I
G
L
I
N
E
-
F
S
K
D
----
I
L
G
H
V
Y
E
----
Y
F
--
L
G
Q
F
-----
A
----------
L
A
E
----
G
K
Q
---
G
G
Q
Y
Y
T
P
K
S
I
-
V
T
-----
L
I
V
--
E
M
L
--
E
--------
P
Y
----
K
G
R
V
Y
D
PAMGSG
G
F
F
V
S
-
S
D
K
F
I
E
K
H
A
------
N
V
K
H
Y
N
A
S
E
----
Q
K
K
Q
I
S
V
Y
G
---
Q
E
S
--
N
P
T
T
W
----
K
L
A
A
M
N
M
---
V
I
R
G
I
D
F
N
F
G
K
K
-
N
A
D
S
F
L
D
-----
D
Q
H
P
D
-
L
R
--
A
D
------------
F
V
M
---
T
N
P
P
F
--------------
N
M
K
D
W
W
H
---
E
K
L
A
D
D
P
-
R
W
T
I
N
T
-----
N
K
R
---
I
L
T
P
----------
P
T
G
N
-
A
N
F
A
W
-----
M
L
H
M
--
L
Y
H
----------
L
A
P
T
G
S
M
A
L
L
L
A
N
G
S
M
SSN
T
-
N
N
E
G
E
I
R
K
T
L
V
E
Q
-
D
L
V
E
C
M
V
-
A
L
P
G
Q
L
F
TNTQ
I
P
A
C
I
W
-------
F
L
T
K
D
K
N
A
K
-
N
G
K
R
DRRG
Q
V
L
F
I
D
A
R
K
-
L
G
Y
M
------
K
D
R
V
L
R
D
F
K
D
E
D
I
Q
K
L
A
D
T
F
H
N
W
Q
Q
EWSEENNQAG
F
C
F
S
A
D
L
A
L
I
R
K
N
DFVLTPGRYVG-------------------------------------------------------------------
17
Fugue
62.21
15%
-114
* C7 *
2BMF
-
?
A:
[169-618]
-------------------------------------------
M
A
S
----
I
E
D
N
P
E
I
E
D
D
I
F
R
--
K
K
R
L
T
I
M
D
-----
L
H
-
P
----
G
-----
A
------
G
K
T
K
R
---
Y
L
P
A
I
V
R
E
------
A
I
K
R
G
L
R
---
T
L
I
L
A
P
T
R
----
V
V
A
A
-
E
M
E
E
A
L
RGLPIRYQTG
R
E
I
V
D
L
M
C
H
----
A
T
F
T
M
R
L
L
S
P
I
R
V
P
-
N
Y
N
L
-
I
I
M
D
E
--
A
--------
H
F
T
D
P
A
-
S
I
A
A
R
G
Y
I
S
T
R
V
E
M
G
E
-----
A
A
-----------------------
G
I
F
--
M
T
A
T
PPGSRDPFPQSNAP
I
M
D
E
E
R
E
I
P
-----------
E
-
R
S
W
N
S
G
--
H
E
W
---
V
T
------
D
F
KGK
T
V
W
F
V
P
S
I
K
A
G
N
D
I
A
A
C
L
R
K
N
G
K
K
V
I
Q
L
S
R
K
----
T
F
D
S
E
Y
I
----
K
T
--
R
T
N
D
W----
D
----------
F
V
V
----
T
T
D
---
I
S
E
M
G
A
N
F
K
A
-
E
R
-----
V
I
D
--
P
R
R
--
C
--------
M
K
----
P
--------------
V
I
-
L
T
D
G
E
E
R
V
I
------
L
A
G
P
M
P
V
T
H
----
S
S
A
A
Q
R
R
G
R
---
V
G
R
--
N
P
K
N
E
---------
N
D
---
Q
Y
I
Y
M
G
E
P
L
--
E
-
N
D
E
D
C
A
H
W
K
E
A
K
M
L
L
D
N
I
N
T
--
P
E
------------
G
I
I
---
P
S
-
M
F
-----------------------------
E
P
-
E
R
E
K
V
D
-----
A
I
D
---
G
E
Y
R
----------
L
R
G
E
-
A
R
K
T
F
-----
V
D
L
M
--
R
R
----------------
G
D
L
P
V
W
L
A
Y
R
V
---
A
-
A
E
G
I
N
Y
A
D
R
R
W
C
F
-
D
G
V
K
N
N
Q
-
I
L
E
E
N
V
E
-------
V
E
I
-------
W
T
K
E
------
G
E
R
K
---------
K
L
K
P
-
R
W
L
D
------
A
R
I
Y
S
D
P
L
A
L
K
E
F
K
E
F
A
A
G
R
K---------------------------------------------------------------------------------------------------------
21
Fugue
58.64
18%
-132
- C3 -
4R3Z
-
SYRC_HUMAN
B:
[17-675]
DV
L
V
S
E
C
S
A
R
L
L
Q
Q
E
E
E
I
K
S
L
T
A
E
I
D
R
LKNCGCLGASPNLE
Q
L
Q
E
E
N
L
K
L
K
Y
R
L
N
I
L
R
K
S
L
Q
A
--
E
R
N
K
P
T
K
N
M
I
N
I
I
S
R
-
L
Q
E
V
F
G
-----
H
A
I
K
A
A
Y
P
D
L
E
N
---
P
P
L
L
V
T
P
S
------
Q
Q
A
K
F
G
------
D
Y
Q
C
N
S
----
A
M
G
I
-
S
-
Q
M
L
-----------
K
T
K
E
Q
K
V
N
P
----
R
E
I
A
E
N
I
T
K
H
L
P
D
N
E
C
I
E
K
-
V
E
I
A
G
-
P
G
--------
F
I
N
V
H
L
R
K
D
F
V
S
E
Q
L
T
S
L
L
V
N
G
V
-----
Q
L
PALGEN
K
K
V
I
V
D
F
SSPNIAKEMH
V
G
H
--
L
R
S
T
--------------
I
I
G
E
S
I
S
R
L
-----------
F
-
E
F
A
--
G
YD
V
L
R
---
L
N
HVGDWG
T
Q
------------
F
G
M
L
I
A
H
L
Q
D
K
F
P
D
Y
L
T
-
V
S
P
P
IG--
D
L
Q
V
F
Y
K
----
E
S
--
K
K
R
F
-----
D
TE
E
E
F
K
K
R
A
Y
Q
C
V
----
V
L
L
---
Q
G
K
N
P
D
I
T
K
A
-
W
K
-----
L
I
C
--
D
V
S
R
Q
E
--------
L
N
----
K
--------------
I
Y
-
D
A
L
D
V
S
L
I
E
------
R
G
E
S
F
Y
Q
D
R
----
M
N
D
I
V
K
E
F
E
---
D
R
G
--
F
V
Q
V
D
DG
R
K
I
V
F
V
P
G
C
S
I
P
L
T
I
V
K
S
D
G
G
Y
T
Y
-
D
T
S
D
L
A
A
I
K
Q
R
L
F
E
E
K
A
-
D
M
--
I
I
------------
Y
V
V
D
NG
Q
S
-
V
H
--------------
F
Q
T
I
F
A
A
---
A
Q
M
I
G
W
Y
-
D
P
K
V
T
R
-----
V
F
H
A
G
F
G
V
V
L
----------
G
E
D
K
-
K
K
F
K
T
-----
R
S
G
E
--
T
V
R
----------
L
M
D
L
L
G
E
G
L
K
R
S
M
D
K
L
---
K
-
E
K
E
R
D
K
V
L
T
A
E
E
L
-
N
A
A
Q
T
S
V
-
A
Y
G
C
I
K
Y
-------
A
D
L
SHNRLND
Y
I
F
S
F
D
K
M
L
-
D
D
R
G
---------
N
T
---
A
A
Y
L
------
L
Y
A
F
T
R
I
R
S
I
A
R
L
A
N
I
D
E
E
M
L
Q
K
A
A
R
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T
K
I
L
L
DH
E
K
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K
L
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C
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R
F
P
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I
L
Q
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I
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D
DLFL
H
T
L
C
D
Y
I
Y
E
L
A
T
A
F
T
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F
Y
DSCYCVEKDRQTGKILKVN
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
RM
19
Fugue
55.36
18%
-134
- C6 -
4IC4
-
A:
[26-397]
------------------------------------------------------
K
S
V
T
R
R
N
D
I
--
P
E
A
A
A
S
P
P
S
L
L
S
F
L
R
-
K
------------------
N
V
G
K
---
D
L
S
S
I
A
M
P
------
V
T
S
N
E
P
I
---
S
I
L
Q
L
I
S
E
----
T
F
------
E
Y
-----------
A
P
L
L
T
K
A
T
Q
----
R
----------
P
D
P
I
T
F
V
S
-
A
F
A
I
S
-
F
L
--------
S
I
Y
R
D
-------
K
T
R
T
L
R
K
P
F
N
P
-----
L
L
-----------------------
A
E
T
--
F
E
L
I
--------------
R
E
D
M
G
F
R
L
I
-----------
S
-
E
K
V
--
S
--
H
R
P
-----------
P
V
------------
F
A
F
F
A
E
H
L
D
W
E
C
S
Y
T
V
T
-
P
S
Q
K
F
WGK
S
I
E
L
N
N
E
----
G
I
--
L
R
L
K
F
KTTG
E
----------
L
F
E
----
W
T
Q
--------
P
T
T
I
L
-
K
N
-----
L
I
A
G
E
R
Y
M
--
E
--------
P
V
----
N
--------------
E
F
E
V
H
S
S
K
G
D
K
S
------
H
I
L
F
D
K
A
G
M
----
F
S
G
R
S
E
G
F
K
---
V
S
I
--
I
P
P
P
S
----
S
N
R
K
K
E
T
---
L
A
G
K
W
T
Q
S
L
A
N
E
-
T
T
H
E
-
T
I
W
E
V
G
D
L
V
S
N
P
-
K
K
--
K
Y
------------
G
F
-----
T
-
K
F
--------------
T
A
N
L
N
E
I
---
T
E
I
E
K
G
N
L
P
P
T
D
S
R
-----
L
R
P
---
D
I
R
A
----------
Y
E
E
G
-
N
V
D
K
A
-----
E
E
W
K
--
L
K
L
----------
E
Q
L
Q
R
E
R
R
N
------------
K
G
Q
D
V
E
P
K
Y
F
E
K
V
-
S
K
------------
N
-------
E
W
K
-------
Y
I
T
G
P
K
S
Y
W
-
E
R
R
K
---------
K
H
D
W
-
S
D
-----------------------
I
S
Q
L
W
----------------------------------------------------------------------------------------------------------
15
Fugue
55.26
19%
-110
- C- -
3WPU
2
?
A:
[3-540]
--------------------------GLQDGPEPTIHTQQAYA
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
SD
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
----
T
-----
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
EDA
N
Q
Y
S
V
N
G
W
E
I
---
I
F
S
L
V
A
D
R
----
N
L
G
F
-
D
D
R
H
V
-----------
F
A
K
I
G
Y
F
Y
R
----
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
G
-
L
V
F
K
E
-
G
----------
V
T
G
Q
I
-
F
E
D
Q
S
F
S
H
Q
T
Q
W
S
G
S
A
-----
R
V
-----------------------
S
K
N
GE
I
K
L
F
--------------
F
T
D
V
A
F
Y
R
N
SDGTNI
K
P
Y
D
P
R
-
I
A
L
--
S
--
V
G
K
---
V
K
------
A
N
------------
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
----
Q
A
----
D
G
T
Y
Y
Q
T
----
G
----
A
Q
N
-----
E
----------
F
F
N
F
R
D
P
F
T
F
---
E
D
P
A
H
P
G
E
T
F
-
M
V
-----
F
E
G
--
N
S
A
--
M
QRET
A
T
C
N
E
A
----
D
--------------
L
G
-
Y
R
Q
G
D
P
Y
A
E
------
T
V
D
D
V
N
A
S
G
----
A
T
Y
Q
I
G
N
V
G
---
L
A
K
A
K
N
K
Q
L
T
----
E
W
E
F
L
P
P
---
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
-
H
R
--
G
T
FAAG
L
D
G
P
E
G
V
Y
G
F
V
---
G
D
-
G
I
--------------
R
S
D
Y
Q
P
L
NGG
S
G
L
A
L
G
--
N
P
T
N
L
N
-----
F
L
G
---
G
Q
P
F
APDFNQHPGH
F
Q
A
Y
-
S
H
Y
V
M
-----
P
G
G
L
--
V
Q
S
F
I
D
T
I
G
T
HD
D
F
V
R
G
G
T
L
A
P
T
V
K
M
D
I
G
---
V
-
G
G
D
P
T
K
T
A
V
D
Y
S
Y
-
G
S
E
G
L
G
G
-
W
A
D
I
P
A
N
-------
K
H
L
-------
F
T
N
G
K
F
G
V
A
V
S
D
E
A
---------
A
Q
K
I
-
R
K
I
L
G
S
K
F
D
-
D
Y
L
D
G
K
P
V
S
A
T
V
R
A
L
I
E
K
L
L
A
Q
Y-------------------------------------------------------------------------------------------------------
16
Fugue
55.18
21%
-111
- C4 -
5AFR
-
?
A:
[8-410]
------------------------------------------------
L
A
N
E
L
I
E
F
V
A
A
T
V
T
G
--
I
K
N
S
P
K
E
N
E
-----------------------------------------------------------
Q
A
F
I
D
Y
----
L
H
C
Q
-
Y
L
E
R
F
-----------
Q
F
F
L
G
L
---------------------
F
V
F
L
F
-
I
V
T
I
D
-
I
A
--------
I
Y
D
A
N
L
-
A
N
S
-------------------------------------------
T
L
L
--
I
I
K
Q
--------------
I
S
A
I
Y
N
A
G
N
-----------
L
-
A
S
I
--
I
--
T
H
G
---
V
S
------
S
V
------------
F
G
Q
L
I
---------------
K
S
----
D
I
D
K
T
R
R
----
K
L
--
D
D
I
S
-----
K
----------
Q
F
Q
----
Q
L
H
---
T
S
I
E
T
P
D
L
L
A
M
V
-------------------------
P
S
----
I
--------------
I
K
-
L
A
V
S
K
G
A
T
S
------
H
-
D
Y
A
N
Y
L
P
----
S
N
D
---------
L
E
S
M-
R
F
L
N
I
----
L
Q
S
I
A
N
K
---
W
F
L
V
L
K
Q
T
L
F
L
D
-
E
V
E
F
W
S
N
F
Y
E
V
L
K
S
L
I
E
-
Q
T
-----------------------
Q
-
S
Q
--------------
E
F
Q
V
C
L
S
---
V
L
T
N
A
K
R
-
F
H
N
L
T
N
-----
L
L
N
---
E
G
S
L
----------
S
D
K
F
K
L
A
D
K
Y
-----
N
Q
F
L
SS
I
P
I
----------
D
E
D
L
Q
E
L
F
P
V
L
A
S
S
L
K
---
K
F
R
Y
S
G
Y
P
V
Q
R
F
V
V
L
M
D
K
I
S
Q
E
V
M
D
A
I
L
S
N
L
--------------------
S
Y
G
S
F
L
-
G
L
Y
E
---------
K
S
A
G
M
I
E
E
W
------
D
D
I
V
Q
D
V
N
L
L
I
R
------------------------------------------------------------------------------------------------------------------
5
HHSearch
37.18
12%
-113
- C8 -
2JLN
2
?
A:
[8-180]
--------------------------------------------------
E
A
R
S
L
L
N
P
S
N
A
P
T
--
R
Y
A
E
R
S
V
----
G
P
F
S
-
L
----
A
-----
A
I
W
F
A
M
A
I
Q
V
A
I
---
F
I
A
A
G
Q
--------
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
----
T
I
A
V
-
I
L
L
F
F
-----------
T
Q
S
A
A
I
R
W
G
----
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
S
L
I
P
-
I
T
L
K
A
-
L
L
--------
S
L
F
W
F
G
-
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
L
-----------------------
P
L
W
--
I
V
I
F
--------------
G
A
I
Q
V
V
T
T
---------------
F
Y
--
G
--
I
T
F
---
I
R
------
W
M
------------
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
-
L
M
L
D
----
G
A
D
V
S
L
G
----
E
V
--
M
S
M
G
-----
G
----------
E
N
P
----
G
M
P
---
F
S
T
A
I
M
I
F
V
G
-
G
W
-----
I
A
V
--
V
V
S
--
I
--------
H
D
----
I
--------------
V
K
-
E
C
K
V
D
P
N
A
S
------
R
E
G
Q
T
K
A
D
A
----
R
Y
A
T
A
Q
W
L
G
---
M
V
P
--
A
S
I
I
F
----
G
F
I
G
A
A
S
---
M
V
L
V
G
E
W
N
P
V
I
A
-
I
T
E
V
V
G
G
V
S
I
P
M
A
I
L
F
Q
-
V
F
--
V
L
------------
L
A
T
---
W
S
-
T
N
--------------
P
A
A
N
L
L
S
---
P
A
Y
T
L
C
S
-
T
F
P
R
V
F
-----
T
F
K
---
T
G
V
I
----------
V
S
A
V
-
V
G
L
L
M
-----
M
P
W
Q
--
F
A
G
----------
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
---
A
-
G
I
M
I
S
D
Y
F
L
V
R
R
R
-
R
I
S
L
H
D
L
-
Y
R
T
K
G
I
Y
-------
T
Y
W
-------
R
G
V
N
W
V
A
L
A
-
V
Y
A
V
---------
A
L
A
V
-
S
F
L
T
------
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
----------------------------------------------------------------------------------------------------------
6
HHSearch
35.93
13%
-119
- C8 -
2XQ2
2
SGLT_VIBPH
A:
[58-197]
--------------------------------------------------------------------------------------------
A
S
L
I
A
A
N
I
S
A
E
Q
---
F
I
G
M
S
G
S
G
------
Y
S
I
G
L
A
I
---
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
-
Y
F
L
P
I
-----------
F
I
E
---
K
G
I
----
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
-
A
V
F
W
I
S
L
Y
--------
I
F
V
N
L
T
-
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
-----------------------
M
Y
S
--
I
L
G
L
--------------
A
L
F
A
L
V
Y
S
I
-----------
Y
G
G
-------
V
V
W
---
T
D
------
V
I
------------
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
----
G
T
D
G
W
F
A
----
G
V
--
S
K
M
V
-----
D
----------
A
A
P
----
G
H
F
---
E
M
I
L
D
Q
S
N
P
Q
-
Y
M
-----
N
L
P
--
G
I
A
--
V
--------
L
I
----
G
--------------
G
L
-
W
V
A
N
L
Y
Y
W
G
------
F
N
Q
Y
I
I
Q
R
T
----
L
A
A
K
S
V
S
E
A
---
Q
K
G
--
I
V
F
A
A
----
F
L
A
L
I
V
P
---
F
L
V
V
L
P
G
I
A
A
Y
V
-
I
T
S
D
P
Q
L
M
A
S
L
G
N
L
P
S
A
-
A
N
--
A
D
------------
K
A
Y
---
P
W
-
L
T
--------------
Q
F
L
P
V
G
V
---
K
G
V
V
F
A
A
-
L
A
A
A
I
V
-----
S
S
L
---
A
S
M
L
----------
N
S
T
A
-
T
I
F
T
M
-----
D
I
Y
K
--
E
Y
I
----------
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
---
A
-
V
V
A
L
I
I
A
A
L
I
A
P
M
-
L
G
G
I
G
Q
C
-
F
Q
Y
I
Q
E
Y
-------
T
G
L
-------
V
S
P
G
I
L
A
V
F
-
L
L
G
L
---------
F
W
K
K
-
T
T
S
K
------
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
----------------------------------------------------------------------------------------------------------
12
HHSearch
34.40
33%
722
- C8 -
2JPJ
-
LCGA_LACLL
A:
[23-37]
----------------------------------------------------
N
L
S
D
V
N
Q
A
S
R
I
--
N
R
K
K
K
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
30.70
14%
-103
- C8 -
3DH4
2
?
A:
[57-167]
----------------------------------------------------------------------------
P
W
W
A
-
V
----
G
-----
A
S
L
I
A
A
N
I
S
A
E
Q
---
F
I
G
M
S
G
S
G
------
Y
S
I
G
L
A
I
---
A
S
Y
E
W
M
S
A
----
I
T
L
I
I
V
G
K
Y
F
-----------
L
P
I
F
I
E
K
G
I
----
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
S
-
L
Y
--------
I
F
V
N
L
T
-
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
-----------------------
M
Y
S
--
I
L
G
L
--------------
A
L
F
A
L
V
Y
S
I
------------------------VV
W
T
D
------
V
I
------------
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
----
G
T
D
G
W
F
A
----
G
V
--
S
K
M
V
-----
D
----------
A
A
P
----
G
H
F
---
E
M
I
L
D
Q
S
N
P
Q
-
Y
M
-----
N
L
P
--
G
I
A
--
V
--------
L
I
----
G
--------------
G
L
-
W
V
A
N
L
Y
Y
W
G
------
F
N
Q
Y
I
I
Q
R
T
----
L
A
A
K
S
V
S
E
A
---
Q
K
G
--
I
V
F
A
A
----
F
L
K
L
I
V
P
---
F
L
V
V
L
P
G
I
A
A
Y
V
-
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
-
N
L
--
P
S
------------
A
A
N
---
A
D
-
K
A
--------------
Y
P
W
L
T
Q
F
---
L
P
V
G
V
K
G
-
V
V
F
A
A
L
-----
A
A
A
---
I
V
S
S
----------
L
A
S
M
-
L
N
S
T
A
-----
T
I
F
T
--
M
D
I
----------
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
---
V
-
G
R
T
A
A
V
V
A
L
I
I
A
C
-
L
I
A
P
M
L
G
-
G
I
G
Q
A
F
Q
-------
Y
I
Q
-------
E
Y
T
G
L
V
S
P
G
-
I
L
A
V
---------
F
L
L
G
-
L
F
W
K
------
K
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
----------------------------------------------------------------------------------------------------------
11
HHSearch
25.90
6%
447
- C2 -
3AJF
1
VSR_RHBVC
A:
[60-77]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
W
-------
M
L
S
H
K
R
D
L
P
-
G
H
Y
R
---------
L
P
L
T
-
C
L
V
S
------
T
Y
S
E
Y
F
V
E
L
K
P
-------------------------------------------------------------------------------------------------------------------
8
HHSearch
22.31
15%
135
- C8 -
3GIA
3
Y609_METJA
A:
[269-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
N
L
--------------
G
F
L
L
I
S
I
---
G
A
L
F
S
I
S
-
S
A
M
N
A
T
-----
I
Y
G
---
G
A
N
V
----------
A
Y
S
L
-
A
K
D
G
E
-----
L
P
E
F
--
F
E
R
----------
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
---
G
-
V
L
F
A
L
L
F
N
M
E
G
V
A
-
S
I
T
S
A
V
F
-
M
V
I
Y
L
F
V
-------
I
L
S
-------
H
Y
I
L
I
D
E
V
G
-
G
R
K
E
---------
I
V
I
F
-
S
F
I
V
------
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
----------------------------------------------------------------------------------------------------------
7
HHSearch
21.00
12%
145
- C8 -
3L1L
1
ADIC_ECO57
A:
[272-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
--------------
A
G
A
I
V
S
F
---
C
A
A
A
G
C
L
-
G
S
L
G
G
W
-----
T
L
L
---
A
G
Q
T
----------
A
K
A
A
-
A
D
D
G
L
-----
F
P
P
I
--
F
A
R
----------
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
---
L
-
M
T
I
F
Q
L
S
S
I
S
P
N
A
-
T
K
E
F
G
L
V
-
S
S
V
S
V
I
F
-------
T
L
V
-------
P
Y
L
Y
T
C
A
A
L
-
L
L
L
G
---------
H
G
H
F
-
G
K
A
R
------
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
----------------------------------------------------------------------------------------------------------
10
HHSearch
20.77
33%
2708
- C1 -
2GPV
-
NCOR2_HUMAN
G:
[10-15]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
A
L
M
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------