@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0767: (2015-12-03 )
MMKKEDYMALALKEAEKGMGFVAPNPLVGAVIVKDDRIISKGYHKRFGDLHAERQAIKNADEDISGSTLYVTLEPCCHVGKQPPCTEALIKSGIKKVVVGSLDPNPLVSGKGIALLRKECLNVEVGILREECDALNERFIFHMTYKQPFVYLKYAMTLDGKIATKTGDSKWISNEHSRQSVQKLRQKCSAIMVGINTVLADNPRLTCRIPKGEALVRIVCDSQLKIPLDSYLVKSAKTIPTWIATCSDNLAQQQTLKEMGCRLIKVPRKDGKLDLKVLMTILGQEGIDSLLIEGGSSLHFSALKAGIVNRLIVFIAPKIIGGLKAKTAISGEGLDWLNQDFRVKDIELSRMDSDVVIEGKVEHYVYRNY
Atome Classification :
(21 SA)
.......-..10........20........30........40.....----...50........60-----........70........80........90........100.......110.......120----.......130.......140.......150.......160.......170.......180.......190.......200......------.210........220.......-230.......240.-......250-.......260....-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMKK
E
D
Y
-
M
A
L
A
L
K
E
A
EKGMGFVAPNP
L
V
G
A
V
I
V
KDDR
I
I
S
K
G
Y
H
K
R
----
F
G
D
L
H
A
E
R
Q
A
I
KNAD-----EDISG
S
T
L
Y
V
T
L
E
P
C
CHVGKQPP
C
T
E
A
L
I
K
S
G
I
K
K
V
V
VGSLDPNPLVSGK
G
I
A
L
L
R
K
E
CLN----V
E
V
G
I
L
R
E
E
C
D
A
L
NE
R
F
I
F
H
M
TYKQ
P
F
V
Y
L
K
Y
A
M
T
LD
G
K
I
ATKTGDSKWIS
N
E
H
S
R
Q
S
V
Q
K
L
R
Q
K
C
S
A
I
M
V
G
I
N
T
VLADNP
R
L
T
C
R------IPK-G
E
A
L
V
R
I
V
CDSQLKI
P
L
D
-
S
Y
L
V
K
SAKTI
P
T
W
I
-
A
TCSD
N
L
A
Q
-
Q
Q
T
L
K
E
MG
C
R
L
I
KV-PRKDGK
L
D
L
K
V
L
M
T
I
LGQE
G
I
D
S
L
L
IEGGSS
L
H
F
S
A
L
K
A
G
I
V
N
R
L
I
V
F
I
A
P
K
I
IGGLK
A
K
T
AISGE
G
L
D
WLNQDF
R
V
K
D
I
E
L
SRMDS
D
V
V
I
EGK
V
E
H
Y
V
YRNY
21
PsiBlast_CBE
91.80
41%
-102
- C3 -
4G3M
3
RIBD_BACSU
D:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
24
PsiBlast_CBE
91.73
41%
-105
- C3 -
3EX8
1
RIBD_BACSU
D:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
30
PsiBlast_CBE
91.68
41%
-103
- C3 -
2B3Z
1
RIBD_BACSU
D:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
31
PsiBlast_CBE
91.39
41%
-102
- C3 -
2B3Z
1
RIBD_BACSU
C:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
27
PsiBlast_CBE
90.97
41%
-103
- C3 -
2D5N
1
RIBD_BACSU
D:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
4
PsiBlast_PDB
90.88
41%
-99
- C3 -
4G3M
2
RIBD_BACSU
A:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
K
------
23
PsiBlast_CBE
90.81
41%
-93
- C3 -
4G3M
3
RIBD_BACSU
B:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
22
PsiBlast_CBE
90.80
41%
-98
- C3 -
4G3M
3
RIBD_BACSU
C:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
28
PsiBlast_CBE
90.58
41%
-101
- C3 -
2D5N
1
RIBD_BACSU
C:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
29
PsiBlast_CBE
90.53
41%
-101
- C3 -
2D5N
2
RIBD_BACSU
B:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
2
PsiBlast_PDB
90.16
41%
-99
- C3 -
2D5N
1
RIBD_BACSU
A:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
32
PsiBlast_CBE
90.04
41%
-99
- C3 -
2B3Z
1
RIBD_BACSU
B:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
26
PsiBlast_CBE
90.04
41%
-99
- C3 -
3EX8
1
RIBD_BACSU
B:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
50
HHSearch
90.02
42%
-96
- C3 -
2B3Z
1
RIBD_BACSU
A:
[13-371]
--
M
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
-
A
P
T
W
I
-
F
T
T
A
R
A
D
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
---
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
25
PsiBlast_CBE
89.73
41%
-101
- C3 -
3EX8
2
RIBD_BACSU
C:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
1
PsiBlast_PDB
89.38
41%
-96
- C3 -
2B3Z
1
RIBD_BACSU
A:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
3
PsiBlast_PDB
88.92
41%
-96
- C3 -
3EX8
1
RIBD_BACSU
A:
[14-369]
---
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
-
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
71
Fugue
87.98
40%
-92
- C3 -
2B3Z
1
RIBD_BACSU
A:
[13-371]
--
M
E
E
Y
Y
-
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
-----
A
H
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
-
T
T
A
R
A
D
E
E
K
-
K
K
R
L
S
A
F
G
V
N
I
F
T
L
-
E
--
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
-------
52
HHSearch
81.79
41%
-91
* C3 *
2HXV
11
?
A:
[12-357]
-
H
M
Y
E
T
F
-
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
----
F
G
G
P
H
A
E
R
M
A
I
E
S
A
R
K
K
G--
E
D
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
V
-
S
G
N
G
V
E
K
F
R
N
H
G
I
E
----
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
D
K
-
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
------
L
K
E
-
G
R
N
P
V
R
V
I
L
D
R
K
G
V
L
S
G
K
V
F
R
V
F
E
E
N
--
A
R
V
I
V
-
F
T
E
S
E
E
A
E
Y
------
P
P
H
V
E
K
A
L
------
S
D
C
S
V
E
S
I
L
R
N
L
Y
E
R
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
--
A
D
V
V
F
G
F
Y
S
T
K
I
F
G
K
G
--
L
D
V
F
S
G
Y
L
S
-
D
V
S
V
P
P
K
F
K
V
V
N
V
E
F
S
D
S
E
F
L
V
E
M
R
P
C
-------
6
PsiBlast_PDB
79.11
35%
-98
- C3 -
3ZPC
4
?
A:
[25-371]
-
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
G
-----
E
Q
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
E
----
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
SLHNID
I
E
T
-
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
P
E
T
V
M
V
M
G
-
P
Y
--------
R
Q
E
L
A
D
L
G
V
I
Q
L
E
I
Q
P
L
K
------
T
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
A
R
A
M
F
N
A
D
F
E
Y
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
Q
------
55
HHSearch
46.15
36%
-70
- C3 -
2B3J
5
TADA_STAAM
A:
[4-154]
M
T
N
D
I
Y
F
-
M
T
L
A
I
E
E
A
K
K
A
A
Q
--
L
G
E
V
P
I
G
A
I
I
T
K
D
D
E
V
I
A
R
A
H
N
L
R
ETLQ
Q
P
T
A
H
A
E
H
I
A
I
E
R
A
A
K
V
L
GS
W
R
L
E
G
C
T
L
Y
V
T
L
E
P
C
V
------
M
C
A
G
T
I
V
M
S
R
I
P
R
V
V
Y
G
A
D
D
P
K
G
G
C
S
G
S
L
M
N
L
L
Q
Q
S
N
F
N
H
R
A
I
V
D
K
G
V
L
K
E
A
C
S
T
L
L
T
T
F
F
K
N
L
R
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------