@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0780: (2015-12-03 )
MSHPKLESSSNKEIITEEVGLLKQLLDEATQKLIGSESFDKIEKIVSLSLTDDYTGLKETISALSNEEMVIVSRYFSILPLLINISEDVDLAYEINYKNNLNQDYLGKLSTTIDVVAGHENAKDILEHVNVVPVLTAHPTQVQRKTVLELTSKIHDLLRKYRDVKAGIVNQEKWYADLRRYIGIIMQTDTIREKKLKVKNEITNVMEYYNRSLIKAVTKLTAEYKALAAKKGIHLENPKPLTMGMWIGGDRDGNPFVTAETLRLSAMVQSEVIINHYIEQLNELYRNMSLSINLTEVSPELVTLANQSQDNSVYRENEPYRKAFNFIQDKLVQTLLNLKVGSSPKEKFVSRQESSDIVGRYIKSHIAQVASDIQTEELPAYATAEEFKQDLLLVKQSLVQYGQDSLVDGELACLIQAVDIFGFYLATIDMRQDSSINEACVAELLKSANIVDDYSSLSEEEKCQLLLKELTEDPRTLSSTHAPKSELLQKELAIFQTARELKDQLGEDIINQHIISHTESVSDMFELAIMLKEVGLIDANQARIQIVPLFETIEDLDNSRDIMTQYLHYELVKKWIATNNNYQEIMLGYSDSNKDGGYLSSGWTLYKAQNELTKIGEENGIKITFFHGRGGTVGRGGGPSYEAITSQPFGSIKDRIRLTEQGEIIENKYGNQDAAYYNLEMLISASIDRMVTRMITNPNEIDNFRETMDGIVSESNAVYRNLVFDNPYFYDYFFEASPIKEVSSLNIGSRPAARKTITEISGLRAIPWVFSWSQNRIMFPGWYGVGSAFKHFIEQDEANLAKLQTMYQKWPFFNSLLSNVDMVLSKSNMNIALQYAQLAGSKEVRDVFNIILNEWQLTKDMILAIEQHDNLLEENPMLHASLDYRLPYFNVLNYVQIELIKRLRSNQLDEDYEKLIHITINGIATGLRNSG
Atome Classification :
(20 SA)
-----------------------.........10.-----.......20........30.....--...40...---------.....50--------.------....---------...60--------..-------------.......70....---------....80.--.......90........100.......110-------------..-------------...------------.-----.120.......--------130.--------------......-140.......150..--...-..160.......------------170...-------.-----.--..----180.......190.......200.......------210.......220..-.....230......-..--.240.-.--------......250.......260--......---.---------------------270.......280.......----290.---......---..300.......310.-----..-.-------...320-..-----....--------...330------------.........------340---.........350.......360-........370--.......380--........------------.390....-----..------.400--........----------.410..----.....420----------------------------....-----------------...430.......440-........450.......460...--....---470.-...-.--------....480...--....490......---.500.....--...510.....----.--...520......--------------.530..---------.--------..-..540------....----....550.......560.......570----.......580...--....590......-------.600..-.....610.......620--........630.......--------640........--------.650.......660.......670----...-------------------------.....-680.......690--.......---..700.......710...--....720--.........730---------------......-------------.740.......750.....-----------------..760-----.......770.-----......780.......790....-...800.----......810---------.........820.......830...-.-.-..840.......850....---..-------.860......---.870....----...880.......890.......900-..-.---------------------------.--------..-.-----.910.....-------..920......---------..930----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MSHPKLESSSNK-----
E
I
I
T
E
E
V
G
L
L
K
Q
L
L
D
E
A
T
Q
K
L
IGS--
E
S
F
D
K
I
E
K
---------
I
V
S
L
SLT--------D------DYT
G
---------
L
K
E
T
---------
I
S
-------------
A
LSNE
E
M
V
I
V
S
R
Y
---------
F
S
I
L
P
L
L
--INISED
V
D
L
A
Y
E
I
NYKNNL
N
Q
D
Y
L
GKL
S
T
T
-------------
I
D
-------------
V
VA------------G-----HE
N
A
K
D
I
L
E
HV--------NV
V
P
--------------
V
LTAH
P
-
T
Q
V
Q
R
K
T
V
L
E
L
T
S
K
I
--
H
D
L
-
L
R
K
Y
R
D
V
K
AGIV------------
N
Q
E
K
W
Y
-------
A
-----
D
--
L
R
----
R
Y
I
G
I
IMQTD
T
I
R
E
K
K
L
K
V
K
N
E
I
T
N
V
M
E
Y
Y
------
N
R
S
L
I
K
A
V
T
K
L
T
A
E
Y
-
K
A
L
A
A
K--KGIHLE-NP--KP
L
-
T
-
M
--------
G
M
W
IGGDRDGN
P
F
V
T
A
E
T
L
--
R
L
S
A
M
V
---
Q
---------------------
S
E
V
I
I
N
H
Y
I
E
Q
L
N
E
L
Y
RNM
S
----
L
--
S
---
I
N
L
T
EV---SP
E
L
V
T
LANQSQDNSV-----YR-E-------N
E
P
Y
---
R
K
-----
A
F
N
F
--------
I
Q
D
K
--------------
L
V
Q
T
L
L
NLK------V-----GS
S
P
K
E
K
F
V
S
R
QE
S
S
D
I
V
G
R
Y
--
I
K
S
H
I
A
Q
V
A
S
D--IQTEELPA----YA
T
A
E
E
F
K
------------
Q
D
L
L
L
V
K
Q
-----
S
L
------
V
Q
----YGQDSLV
D
----------
G
E
L
A
C
L
----
I
Q
A
V
D
I
F
G
----------------------------
F
Y
L
A
-----------------
T
I
DMRQDSSI
N
E
A
C
V
--
A
E
L
L
K
SANIV
D
D
Y
S
SL
S
E
E
E
K
C
Q
L
--
L
L
K
E
---L--T-EDP-R--------TLSSTHA
P
K
S
--
E
L
L
Q
K
E
L
A
I
F
Q
T
A
---
R
E
L
-
K
D
Q
L
G
--
E
D
I
I
--
N
Q
H
I
I
----
S
--
H
T
E
S
V
S
D
M
F
E
L
A
--------------
I
M
L
K
E
V---------G--------LI-DANQ-------
A
R
I
Q
----
I
V
P
L
F
E
T
I
E
D
LDN
S
R
D
I
M
T
Q
Y
L
H
Y
E
L
V
----
K
K
W
I
ATNN
N
Y
Q
E
I
--
M
L
GYSDSNKDG
G
Y
-------LSSG
W
T
-
L
Y
KAQ
N
E
L
T
KIGEEN
G
I
---
K
I
T
F
F
HGRGGTVGRGGGP--------S--Y
E
A
ITSQP--------
F
G
S
I
K
D
R
IRLTEQG
E
I
I
E
N
KYGN-----QD
A
-------------------------
A
Y
Y
N
L
-
E
M
L
I
S
A
S
I
D
R
M
----
V
T
R
MIT
N
---
P
N
E
I
D
N
F
R
E
T
M
D
G
I
VSES--NAV
Y
R
----NLVFDNPY
F
Y
D
Y
---------------
F
FEASP-------------
I
K
E
V
S
SLNIGSRPA
A
R
K
T
I
-----------------
T
E
ISG-----
L
R
AI
P
W
V
FSWS-----Q
N
R
I
M
FP
G
W
Y
G
V
G
S
A
F
K
H
F
I
EQD-E
A
N
L
A
K
L
----
Q
T
M
Y
Q
KW-----------
P
F
F
N
S
L
L
S
N
V
D
M
V
LSKSN
M
N
I
A
L
Q
Y
-
A
-
Q
-LAG
S
K
E
V
R
D
V
F
N
I
I
L
N
E
W
Q
---L
T
-------
K
D
M
I
L
A
I
E
Q
H---D
N
L
L
E
ENP----
M
L
H
A
SLDYRL
P
Y
F
N
V
L
N
Y
V
Q
I
E
L
I
K
--
R
L
-R---------------------------S--------NQ-L-----
D
E
D
Y
E
K
L
I
H
-------
I
T
I
N
-
G
I
ATGL---------RNSG-----------------------------
2
PsiBlast_PDB
97.57
30%
-68
- C3 -
4BXH
3
CAPPA_FLATR
A:
[49-990]
-------------------------------
S
E
D
D
-----
K
L
V
E
Y
D
A
L
L
L
D
K
F
L
D
-
I
L
Q
D
L
H
G
E
--
D
L
K
E
A
V
Q
Q
---------
C
Y
E
L
S
A
----------------
E
Y
E
G
KHD
P
K
K
L
E
E
L
G
S
L
---------
L
T
-------------
S
L
D
T
G
D
S
I
V
I
A
K
A
---------
F
S
H
M
L
N
L
--
A
N
L
A
E
E
L
Q
I
A
Y
R
R
R
I
K
L
K
-
S
G
D
F
A
D
E
A
N
A
T
-------------
T
E
S
D
I
E
E
T
F
K
R
L
V
HK
L
N
K
------------
S
-----
P
E
E
V
F
D
A
L
K
N
Q
--------
T
V
E
L
--------------
V
L
T
A
H
P
-
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
--
R
N
C
-
L
A
Q
L
Y
A
K
D
I
T
P
D
------------
D
K
Q
E
L
D
-------
E
-----
A
--
L
H
----
R
E
I
Q
A
A
F
R
T
D
E
I
R
-
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
------
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
-
D
T
A
L
K
N
--
I
G
I
N
E
R
-
F
P
YN
A
P
L
I
Q
-
F
--------
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
--
R
D
V
C
L
L
---
A
---------------------
R
M
M
T
S
N
M
Y
F
S
Q
I
E
D
L
M
I
E
M
S
----
M
--
W
---
R
C
N
S
E
L
R
V
R
A
E
E
L
Y
R
T
A
R
K
D
V
K
H
Y
I
EFWKR
I
P
-
P
-------
N
Q
P
Y
---
R
V
-----
I
L
G
D
--------
V
R
D
K
--------------
L
Y
N
T
---------------------------
R
E
R
S
R
H
L
----------
L
V
D
G
K
S
D
--
I
P
D
E
A
V
------
Y
T
N
V
E
Q
L
L
------------
E
P
L
E
L
C
Y
R
-----
S
L
------
C
D
----
C
G
D
H
V
I
A
D
----------
G
S
L
L
D
F
----
L
R
Q
V
S
T
F
G
----------------------------
L
S
L
V
-----------------
K
L
D
I
R
Q
E
S
D
R
H
T
E
V
L
--
D
A
I
T
Q
H
L
G
I
-
G
S
Y
R
E
W
S
E
E
K
R
Q
E
W
--
L
L
A
E
---
L
--
S
--
G
K
-
R
--------
P
L
I
G
P
D
L
P
K
T
--
E
E
V
K
D
C
L
D
T
F
K
V
L
---
A
E
L
-
P
S
------
D
C
F
--
G
A
Y
I
I
----
S
--
M
A
T
S
T
S
D
V
L
A
V
E
--------------
L
L
Q
R
E
Y
---------
H
--------
I
-----
K
-------
H
P
L
R
----
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
T
R
L
F
S
M
D
W
Y
----
R
N
R
I
---
D
G
K
Q
E
V
--
M
I
G
Y
S
D
S
G
K
D
A
G
R
-------
F
S
A
A
W
Q
-
L
Y
K
T
Q
E
Q
I
V
K
I
A
K
E
F
G
V
---
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
G
P
--------
T
--
H
L
A
L
L
S
Q
P
--------
P
D
T
I
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
-----
E
H
L
-------------------------
C
F
R
T
L
-
Q
R
F
C
A
A
T
L
E
H
G
----
M
N
P
P
I
S
P
---
R
P
E
---
W
R
E
L
M
D
Q
M
A
V
V
A
--
T
E
E
Y
R
----
S
V
V
F
K
E
P
R
F
V
E
Y
---------------
F
R
L
A
T
P
-------------
E
L
E
F
G
R
M
N
---
R
P
S
K
---------------------
G
G
I
E
S
-----
L
R
A
I
P
W
I
F
S
W
T
-----
Q
T
R
F
H
L
P
V
W
L
G
F
G
A
A
F
K
H
A
I
Q
K
D
-
S
K
N
L
Q
M
L
----
Q
E
M
Y
K
T
W
-----------
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
N
P
G
I
A
A
L
N
-
D
-
K
-
L
L
V
S
E
D
L
R
P
F
G
E
S
L
R
A
N
Y
E
---
E
T
-------
K
N
Y
L
L
K
I
A
G
H
---
K
D
L
L
E
G
D
P
----
Y
L
K
Q
G
I
R
L
R
D
P
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
--
R
I
-
R
---------------------------
D
PNYHVTLR
P
H
-
I
-----
S
K
E
Y
-----G
L
E
D
T
L
I
L
T
M
K
-
G
I
A
A
G
M
---------
Q
N
T
G
-----------------------------
1
PsiBlast_PDB
97.45
30%
-69
- C3 -
3ZGE
3
CAPPA_FLATR
A:
[49-990]
-------------------------------
S
E
D
D
-----
K
L
V
E
Y
D
A
L
L
L
D
K
F
L
D
-
I
L
Q
D
L
H
G
E
--
D
L
K
E
A
V
Q
Q
---------
C
Y
E
L
S
A
----------------
E
Y
E
G
KHD
P
K
K
L
E
E
L
G
S
L
---------
L
T
-------------
S
L
D
T
G
D
S
I
V
I
A
K
A
---------
F
S
H
M
L
N
L
--
A
N
L
A
E
E
L
Q
I
A
Y
R
R
R
I
K
L
K
-
S
G
D
F
A
D
E
A
N
A
T
-------------
T
E
SD
I
E
E
T
F
K
R
L
V
H
K
L
N
K
------------
S
-----
P
E
E
V
F
D
A
L
K
N
Q
--------
T
V
E
L
--------------
V
L
T
A
H
P
-
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
--
R
N
C
-
L
A
Q
L
Y
A
-
D
I
T
P
D
------------
D
K
Q
E
L
D
-------
E
-----
A
--
L
H
----
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
------
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
-
D
T
A
L
K
N
--
I
G
I
N
E
R
-
F
P
YN
A
P
L
I
Q
-
F
--------
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
--
R
D
V
C
L
L
---
A
---------------------
R
M
M
T
S
N
M
Y
F
S
Q
I
E
D
L
M
I
E
M
S
----
M
--
W
---
R
C
N
S
E
L
R
V
R
A
E
E
L
Y
R
T
------
H
Y
I
EFWKR
I
P
-
P
-------
N
Q
P
Y
---
R
V
-----
I
L
G
D
--------
V
R
D
K
--------------
L
Y
N
T
---------------------------
R
E
R
S
R
H
L
----------
L
V
D
G
K
S
D
--
I
P
D
E
A
V
------
Y
T
N
V
E
Q
L
L
------------
E
P
L
E
L
C
Y
R
-----
S
L
------
C
D
----
C
G
D
H
V
I
A
D
----------
G
S
L
L
D
F
----
L
R
Q
V
S
T
F
G
----------------------------
L
S
L
V
-----------------
K
L
D
I
R
Q
E
S
D
R
H
T
E
V
L
--
D
A
I
T
Q
H
L
G
I
-
G
S
Y
R
E
W
S
E
E
K
R
Q
E
W
--
L
L
A
E
---
L
--
S
--
G
K
-
R
--------
P
L
I
G
P
D
L
P
K
T
--
E
E
V
K
D
C
L
D
T
F
K
V
L
---
A
E
L
-
P
S
------
D
C
F
--
G
A
Y
I
I
----
S
--
M
A
T
S
T
S
D
V
L
A
V
E
--------------
L
L
Q
R
E
Y
---------
H
--------
I
-----
K
-------
H
P
L
R
----
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
T
R
L
F
S
M
D
W
Y
----
R
N
R
I
---
D
G
K
Q
E
V
--
M
I
G
Y
S
D
S
G
K
D
A
G
R
-------
F
S
A
A
W
Q
-
L
Y
K
T
Q
E
Q
I
V
K
I
A
K
E
F
G
V
---
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
G
P
--------
T
--
H
L
A
L
L
S
Q
P
--------
P
D
T
I
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
-----
E
H
L
-------------------------
C
F
R
T
L
-
Q
R
F
C
A
A
T
L
E
H
G
----
M
N
P
P
I
S
P
---
R
P
E
---
W
R
E
L
M
D
Q
M
A
V
V
A
--
T
E
E
Y
R
----
S
V
V
F
K
E
P
R
F
V
E
Y
---------------
F
R
L
A
T
P
-------------
E
L
E
F
G
R
------------------------------
G
G
I
E
S
-----
L
R
A
I
P
W
I
F
S
W
T
-----
Q
T
R
F
H
L
P
V
W
L
G
F
G
A
A
F
K
H
A
I
Q
K
D
-
S
K
N
L
Q
M
L
----
Q
E
M
Y
K
T
W
-----------
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
N
P
G
I
A
A
L
N
-
D
-
K
-
L
L
V
S
E
D
L
R
P
F
G
E
S
L
R
A
N
Y
E
---
E
T
-------
K
N
Y
L
L
K
I
A
G
H
---
K
D
L
L
E
G
D
P
----
Y
L
K
Q
G
I
R
L
R
D
P
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
--
R
I
-
R
---------------------------
D
PNYHVTLR
P
H
-
I
-----
S
K
E
------G
L
E
D
T
L
I
L
T
M
K
-
G
I
A
A
G
M
---------
Q
N
T
G
-----------------------------
3
PsiBlast_PDB
96.18
30%
-69
- C3 -
3ZGB
4
CAPP1_FLAPR
A:
[31-972]
-------------------------------
S
E
D
D
-----
K
L
I
E
Y
D
A
L
L
L
D
K
F
L
D
-
I
L
Q
D
L
H
G
E
--
D
L
K
E
A
V
Q
E
---------
C
Y
E
L
S
A
----------------
E
Y
E
G
KHD
P
K
K
L
E
E
L
G
S
V
---------
L
T
-------------
S
L
D
P
G
D
S
I
V
I
A
K
A
---------
F
S
H
M
L
N
L
--
A
N
L
A
E
E
V
Q
I
A
Y
R
R
R
I
K
L
K
-
R
G
D
F
A
D
E
A
N
A
T
TESD
I
E
E
T
F
K
K
L
V
L
K
-------------
L
N
K
------------
S
-----
P
E
E
V
F
D
A
L
K
N
Q
--------
T
V
D
L
--------------
V
L
T
A
H
P
-
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
--
R
N
C
-
L
A
Q
L
Y
A
K
D
I
T
P
D
------------
D
K
Q
E
L
D
-------
E
-----
A
--
L
H
----
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
------
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
-
D
T
A
L
K
N
--
I
G
I
N
E
R
-
V
P
YN
A
P
L
-
I
Q
F
--------
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
--
R
D
V
C
L
L
---
A
---------------------
R
M
M
A
S
N
M
Y
F
S
Q
I
E
D
L
M
F
E
M
S
----
M
--
W
---
R
C
N
S
E
L
R
V
R
A
E
E
L
Y
R
T
---------Q----
V
P
-
P
-------
T
E
P
Y
---
R
V
-----
I
L
G
D
--------
V
R
D
K
--------------
L
Y
N
T
---------------------------
R
E
R
S
R
H
L
L
A
H
G
--
I
--------
S
D
--
I
P
E
E
A
V
------
Y
T
N
V
E
Q
F
L
------------
E
P
L
E
L
C
Y
R
-----
S
L
------
C
D
----
C
G
D
R
V
I
A
D
----------
G
S
L
L
D
F
----
L
R
Q
V
S
T
F
G
----------------------------
L
S
L
V
-----------------
K
L
D
I
R
Q
E
S
D
R
H
T
D
V
L
--
D
A
I
T
Q
H
L
E
I
-
G
S
Y
R
E
W
S
E
E
K
R
Q
E
W
--
L
L
A
E
---
L
--
S
-
G
K
--
R
--------
P
L
F
G
S
D
L
P
K
T
--
E
E
V
K
D
V
L
D
T
F
N
V
L
---
A
E
L
-
P
S
------
D
C
F
--
G
A
Y
I
I
----
S
--
M
A
T
S
P
S
D
V
L
A
V
E
--------------
L
L
Q
R
E
C
---------
H
--------
V
-----
K
-------
H
P
L
R
----
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
A
R
L
F
S
I
D
W
Y
----
R
N
R
I
---
D
G
K
Q
E
V
--
M
I
G
Y
S
D
S
G
K
D
A
G
R
-------
F
S
A
A
W
Q
-
L
Y
K
A
Q
E
E
I
I
K
V
A
K
E
F
G
V
---
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
G
P
--------
T
--
H
L
A
I
L
S
Q
P
--------
P
D
T
I
H
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
-----
E
H
L
-------------------------
C
F
R
T
L
-
Q
R
F
C
A
A
T
L
E
H
G
----
M
N
P
P
I
S
P
---
R
P
E
---
W
R
E
L
M
D
Q
M
A
V
V
A
--
T
E
E
Y
R
----
S
I
V
F
K
E
P
R
F
V
E
Y
---------------
F
R
L
A
T
P
-------------
E
L
E
Y
G
R
M
N
I
G
S
R
P
S
K
---------------------
G
G
I
E
S
-----
L
R
A
I
P
W
I
F
A
W
T
-----
Q
T
R
F
H
L
P
V
W
L
G
F
G
A
A
F
K
H
A
I
K
K
D
-
S
K
N
L
Q
M
L
----
Q
E
M
Y
K
T
W
-----------
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
D
P
G
I
A
A
L
N
-
D
-
K
-
L
L
V
S
E
D
L
W
P
F
G
E
S
L
R
A
N
Y
E
---
E
T
-------
K
D
Y
L
L
K
I
A
G
H
---
R
D
L
L
E
G
D
P
----
Y
L
K
Q
R
I
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
--
R
I
-
R
---------------------------
D
PNYHVTLR
P
H
-
I
-----
S
K
-------G
L
E
D
T
L
I
L
T
M
K
-
G
I
A
A
G
M
---------
Q
N
T
G
-----------------------------
5
PsiBlast_PDB
91.44
29%
-71
- C3 -
1JQN
3
CAPP_ECOLI
A:
[12-883]
----------------------------------------------
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
--
H
I
L
E
R
V
E
T
---------
I
R
K
L
S
K
S
--------
S
R
A
GN
D
A
N
R
Q
E
---------
L
L
T
T
---------
L
Q
-------------
N
L
S
N
D
E
L
L
P
V
A
R
A
---------
F
S
---
Q
F
--
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
--------
G
E
A
A
S
N
-------------
P
E
-------------
V
I
A
R
T
L
R
K
L
K
N
QPEL
S
-----
E
D
T
I
K
K
A
V
E
S
L
--------
S
L
E
L
--------------
V
L
T
A
H
P
-
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
--
N
A
C
-
L
K
Q
L
D
N
K
D
I
A
D
Y
------------
E
H
N
Q
L
M
-------
R
-----
R
--
L
R
----
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
------
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
N
--
L
G
Y
K
L
P
V
E
F
--
V
P
V
-
R
-
F
--------
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
--
R
H
V
L
L
L
---
S
---------------------
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
----
M
---------
V
E
A
---
T
P
E
L
L
A
L
V
G
E
E
G
------------
A
-------
A
E
P
Y
---
R
Y
-----
L
M
K
N
--------
L
R
S
R
--------------
L
M
A
T
Q
--------------------------------------------
A
W
L
E
A
R
--
L
K
G
E
E
L
P
K
PEGL
L
T
Q
N
E
E
L
W
------------
E
P
L
Y
A
C
Y
Q
-----
S
L
------
Q
A
----
C
G
M
G
I
I
A
N
----------
G
D
L
L
D
T
----
L
R
R
V
K
C
F
G
----------------------------
V
P
L
V
-----------------
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
--
G
E
L
T
R
Y
L
G
I
-
G
D
Y
E
S
W
S
E
A
D
K
Q
A
F
--
L
I
R
E
---
L
--
N
-
S
K
R
-
P
--------
L
L
P
R
N
W
Q
P
S
A
--
E
T
R
E
----
V
L
D
T
C
---
Q
V
I
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A
E
A
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P
--
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G
S
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--
A
A
Y
V
I
----
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--
M
A
K
T
P
S
D
V
L
A
V
H
--------------
L
L
L
K
E
A
---------
G
--------
I
G
-
F
A
-----------
M
P
----
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A
P
L
F
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T
L
D
D
L
N
N
A
N
D
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M
T
Q
L
L
N
I
D
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Y
----
R
G
L
I
---
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G
K
Q
M
V
--
M
I
G
Y
S
D
S
A
K
D
A
G
V
-------
M
A
A
S
W
A
-
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
---
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
A
P
--------
A
--
H
A
A
L
L
S
Q
P
--------
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
-----
P
E
I
-------------------------
T
V
S
S
L
-
S
L
Y
T
G
A
I
L
E
-------
A
N
L
L
P
P
---
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
--
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
---------------
F
R
S
A
T
P
-------------
E
Q
E
L
G
K
L
P
L
G
S
R
P
-----------------------
G
G
V
E
S
-----
L
R
A
I
P
W
I
F
A
W
T
-----
Q
N
R
L
M
L
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
---
D
G
K
Q
S
E
L
----
E
A
M
C
R
D
W
-----------
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
-
D
-
Q
-
R
L
V
D
K
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
---
E
D
-------
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
----
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
--
R
S
-
R
Q
A
E
K
E
----------------------
G
--------
Q
E
-
P
-----
D
P
R
V
E
Q
A
L
M
-------
V
T
I
A
-
G
I
A
A
G
M
---------
R
N
T
G
-----------------------------
6
PsiBlast_PDB
90.34
29%
-71
- C3 -
1FIY
1
CAPP_ECOLI
A:
[12-883]
----------------------------------------------
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
--
H
I
L
E
R
V
E
T
---------
I
R
K
L
S
K
S
--------
S
R
A
GN
D
A
N
R
Q
E
---------
L
L
T
T
---------
L
Q
-------------
N
L
S
N
D
E
L
L
P
V
A
R
A
---------
F
S
---
Q
F
--
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
--------
G
E
A
A
S
N
-------------
P
E
-------------
V
I
A
R
T
L
R
K
L
K
N
QPEL
S
-----
E
D
T
I
K
K
A
V
E
S
L
--------
S
L
E
L
--------------
V
L
T
A
H
P
-
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
--
N
A
C
-
L
K
Q
L
D
N
K
D
I
A
D
Y
------------
E
H
N
Q
L
M
-------
R
-----
R
--
L
R
----
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
------
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
N
--
L
G
Y
K
L
P
V
E
F
--
V
P
V
-
R
-
F
--------
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
--
R
H
V
L
L
L
---
S
---------------------
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
----
M
---------
V
E
A
---
T
P
E
L
L
A
L
V
G
E
E
G
------------
A
-------
A
E
P
Y
---
R
Y
-----
L
M
K
N
--------
L
R
S
R
--------------
L
M
A
T
Q
--------------------------------------------
A
W
L
E
A
R
--
L
K
G
E
E
L
P
K
PEGL
L
T
Q
N
E
E
L
W
------------
E
P
L
Y
A
C
Y
Q
-----
S
L
------
Q
A
----
C
G
M
G
I
I
A
N
----------
G
D
L
L
D
T
----
L
R
R
V
K
C
F
G
----------------------------
V
P
L
V
-----------------
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
--
G
E
L
T
R
Y
L
G
I
-
G
D
Y
E
S
W
S
E
A
D
K
Q
A
F
--
L
I
R
E
---
L
--
N
-
S
K
R
-
P
--------
L
L
P
R
N
W
Q
P
S
A
--
E
T
R
E
----
V
L
D
T
C
---
Q
V
I
-
A
E
A
-
P
--
Q
G
S
I
--
A
A
Y
V
I
----
S
--
M
A
K
T
P
S
D
V
L
A
V
H
--------------
L
L
L
K
E
A
---------
G
--------
I
G
-
F
A
-----------
M
P
----
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
----
R
G
L
I
---
Q
G
K
Q
M
V
--
M
I
G
Y
S
D
S
A
K
D
A
G
V
-------
M
A
A
S
W
A
-
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
---
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
A
P
--------
A
--
H
A
A
L
L
S
Q
P
--------
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
-----
P
E
I
-------------------------
T
V
S
S
L
-
S
L
Y
T
G
A
I
L
E
-------
A
N
L
L
P
P
---
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
--
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
---------------
F
R
S
A
T
P
-------------
E
Q
E
L
G
K
L
P
L
G
S
R
P
A
------------------------
V
E
S
-----
L
R
A
I
P
W
I
F
A
W
T
-----
Q
N
R
L
M
L
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
---
D
G
K
Q
S
E
L
----
E
A
M
C
R
D
W
-----------
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
-
D
-
Q
-
R
L
V
D
K
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
---
E
D
-------
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
----
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
--
R
S
-
R
Q
A
E
K
E
----------------------
G
--------
Q
E
-
P
-----
D
P
R
V
E
Q
A
L
M
-------
V
T
I
A
-
G
I
A
A
G
M
---------
R
N
T
G
-----------------------------
7
PsiBlast_PDB
90.10
29%
-61
- C3 -
4UOL
6
CAPP1_MAIZE
A:
[33-936]
----------------------------------------------------------------------------------------
V
S
--------
A
------
D
Y
E
G
---------
K
G
D
T
T
K
L
G
E
L
G
A
K
L
T
-------------
G
L
A
P
A
D
A
I
L
V
A
S
-----------
S
I
L
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
-
R
R
N
S
K
L
------------------------
S
D
-------------
I
--------------------
E
E
T
L
K
R
L
V
S
E
V
--------
G
K
S
P
E
E
V
F
E
A
L
K
N
Q
T
V
D
L
V
F
T
A
H
P
-
T
Q
S
A
R
R
S
L
L
Q
K
N
A
R
I
--
R
N
C
-
L
T
Q
L
N
--
A
K
D
I
T
------------
D
D
D
K
Q
E
-------
L
-----
D
E
A
L
Q
----
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
A
Q
P
T
P
Q
D
E
M
R
Y
G
M
S
Y
I
------
H
E
T
V
W
K
G
V
P
K
F
L
R
R
V
-
D
T
A
L
K
N
--
I
G
I
N
E
R
-
L
P
--
Y
N
V
-
S
-
L
I
R
F
-----
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
--
R
D
V
C
L
L
---
A
---------------------
R
M
M
A
A
N
L
Y
I
D
Q
I
E
E
L
M
F
E
L
S
----
M
WR
C
---
N
D
E
L
R
V
---
R
A
E
E
L
H
S
S
S
G
S
K
V
T
K
Y
-----
Y
I
-
E
F
W
K
Q
IPP
N
E
P
Y
---
R
V
-----
I
L
G
H
--------
V
R
D
K
--------------
L
Y
N
T
---------------------
R
E
R
-----------
A
R
H
--
L
---
L
A
S
G
V
S
E
--
I
S
A
E
S
--
S
----
F
T
S
I
E
E
F
L
------------
E
P
L
E
L
C
Y
K
-----
S
L
------
C
D
----
C
G
D
K
A
I
A
D
----------
G
S
L
L
D
L
----
L
R
Q
V
F
T
F
G
----------------------------
L
S
L
V
-----------------
K
L
D
I
R
Q
E
S
E
R
H
T
D
V
I
--
D
A
I
T
T
H
L
G
I
-
G
S
Y
R
E
W
S
E
D
K
R
Q
E
W
--
L
L
S
E
---
L
----
R
G
K
-
R
--------
P
L
L
P
P
D
L
P
Q
T
--
E
E
I
A
D
V
I
G
A
F
H
V
L
---
A
E
L
-
P
------
P
D
S
F
--
G
P
Y
I
I
----
S
--
M
A
T
A
P
S
D
V
L
A
V
E
--------------
L
L
Q
R
E
C
---------
G
--------
V
-----
R
-------
Q
P
L
P
----
V
V
P
L
F
E
R
L
A
D
L
Q
S
A
P
A
S
V
E
R
L
F
S
---
V
----
D
W
Y
M
D
R
I
K
G
K
Q
Q
V
--
M
V
G
Y
S
D
S
G
K
D
A
G
R
-------
L
S
A
A
W
Q
-
L
Y
R
A
Q
E
E
M
A
Q
V
A
K
R
Y
G
V
---
K
L
T
L
F
H
G
R
G
G
T
V
G
R
G
G
G
P
--------
T
--
H
L
A
I
L
S
Q
P
--------
P
D
T
I
N
G
S
I
R
V
T
V
Q
G
E
V
I
E
F
C
F
G
E
-----
E
H
L
-------------------------
C
F
Q
T
L
-
Q
R
F
T
A
A
T
L
E
H
G
----
M
H
P
P
V
S
P
---
K
P
E
---
W
R
K
L
M
D
E
M
A
V
V
A
--
T
E
E
Y
R
----
S
V
V
V
K
E
A
R
F
V
E
Y
---------------
F
R
S
A
T
P
-------------
E
T
E
Y
G
R
M
N
I
G
S
R
P
A
K
R
R
P
G
-----------------
G
G
I
T
T
-----
L
R
A
I
P
W
I
F
S
W
T
-----
Q
T
R
F
H
L
P
V
W
L
G
V
G
A
A
F
K
F
A
I
D
K
D
-
V
R
N
F
Q
V
L
----
K
E
M
Y
N
E
W
-----------
P
F
F
R
V
T
L
D
L
L
E
M
V
F
A
K
G
D
P
G
I
A
G
L
Y
-
D
-
E
-
L
L
V
A
E
E
L
K
P
F
G
K
Q
L
R
D
K
Y
V
---
E
T
-------
Q
Q
L
L
L
Q
I
A
G
H
---
K
D
I
L
E
G
D
P
----
F
L
K
Q
G
L
V
L
R
N
P
Y
I
T
T
L
N
V
F
Q
A
Y
T
L
K
--
R
I
-
R
D
P
N
F
K
V
T
P
Q
P
P
LSKEFADEAGLVKLNP
A
--------
S
E
-
Y
-----
P
P
G
L
E
D
T
L
I
-------
L
T
M
K
-
G
I
A
A
G
M
---------
Q
N
T
G
-----------------------------
21
HHSearch
89.92
30%
-68
- C3 -
1JQN
3
CAPP_ECOLI
A:
[4-883]
---------------------------------
Q
Y
-----
S
A
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
--
H
I
L
E
R
V
E
T
---------
I
R
K
L
S
K
S
S
R
A
GN
D
--
A
------
N
R
Q
E
---------
L
L
T
T
---------
L
Q
-------------
N
L
S
N
D
E
L
L
P
V
A
R
A
---------
F
S
Q
F
L
N
L
--
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
E
A
A
----
S
N
P
E
V
I
A
R
T
-------------
L
R
-------------
K
L
K
------------
N
QPELS
E
D
T
I
K
K
A
V
E
S
L
--------
S
L
E
L
--------------
V
L
T
A
H
P
-
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
--
N
A
C
-
L
K
Q
L
D
N
K
D
I
A
D
Y
------------
E
H
N
Q
L
M
-------
R
-----
R
--
L
R
----
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
------
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
-
N
E
Q
L
E
E
N
L
G
Y
K
L
P
V
-
E
F
--
V
P
V
-
R
-
F
--------
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
--
R
H
V
L
L
L
---
S
---------------------
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
----
M
--
V
---
E
A
T
P
E
L
---
L
A
L
----
V
G
------
E
-----
E
G
-
A
-------
A
E
P
Y
---
R
Y
-----
L
M
K
N
--------
L
R
S
R
--------------
L
M
A
T
Q
A
W
L
E
------
A
-----
R
L
K
G
E
-------------------------------
E
L
P
K
P
E
G
L
----
L
T
Q
N
E
E
L
W
------------
E
P
L
Y
A
C
Y
Q
-----
S
L
------
Q
A
----
C
G
M
G
I
I
A
N
----------
G
D
L
L
D
T
----
L
R
R
V
K
C
F
G
----------------------------
V
P
L
V
-----------------
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
--
G
E
L
T
R
Y
L
G
I
-
G
D
Y
E
S
W
S
E
A
D
K
Q
A
F
--
L
I
R
E
---
L
--
N
--
S
K
-
R
--------
P
L
L
P
R
N
W
Q
P
S
--
A
E
T
R
E
V
L
D
T
C
Q
V
I
---
A
E
A
-----
P
--
Q
G
S
I
--
A
A
Y
V
I
----
S
--
M
A
K
T
P
S
D
V
L
A
V
H
--------------
L
L
L
K
E
A
---------
G
--------
I
-----
G
-------
F
A
M
P
----
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
----
R
G
L
I
Q
---
G
K
Q
M
V
--
M
I
G
Y
S
D
S
A
K
D
A
G
V
-------
M
A
A
S
W
A
-
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
---
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
A
P
--------
A
--
H
A
A
L
L
S
Q
P
--------
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
-----
P
E
I
-------------------------
T
V
S
S
L
-
S
L
Y
T
G
A
I
L
E
A
N
----
L
L
P
P
P
E
------
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
--
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
---------------
F
R
S
A
T
P
-------------
E
Q
E
L
G
K
L
P
L
G
S
R
P
-----------------------
G
G
V
E
S
-----
L
R
A
I
P
W
I
F
A
W
T
-----
Q
N
R
L
M
L
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
---
G
K
Q
S
E
L
----
E
A
M
C
R
D
W
-----------
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
-
R
-
L
V
-
D
K
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
---
E
D
-------
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
----
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
--
R
S
-
R
---------------------------
Q
--------
A
E
-
K
E
GQEP
D
P
R
V
E
Q
A
L
M
-------
V
T
I
A
-
G
I
A
A
G
M
---------
R
N
T
G
-----------------------------
4
PsiBlast_PDB
87.13
29%
-86
- C- -
1QB4
2
CAPP_ECOLI
A:
[12-883]
----------------------------------------------
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
--
H
I
L
E
R
V
E
T
---------
I
R
K
L
S
K
S
--------
S
R
A
GN
D
A
N
R
Q
E
---------
L
L
T
T
---------
L
Q
-------------
N
L
S
N
D
E
L
L
P
V
A
R
A
---------
F
S
---
Q
F
--
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
--------
G
E
A
A
S
N
-------------
P
E
-------------
V
I
A
R
T
L
R
K
L
K
N
QPEL
S
-----
E
D
T
I
K
K
A
V
E
S
L
--------
S
L
E
L
--------------
V
L
T
A
H
P
-
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
--
N
A
C
-
L
K
Q
L
D
N
K
D
I
A
D
Y
------------
E
H
N
Q
L
M
-------
R
-----
R
--
L
R
----
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
------
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
N
--
L
G
Y
K
L
P
V
E
F
--
V
P
V
-
R
-
F
--------
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
--
R
H
V
L
L
L
---
S
---------------------
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
----
M
---------
V
E
A
---
T
P
E
L
L
A
L
V
G
E
E
G
------------
A
-------
A
E
P
Y
---
R
Y
-----
L
M
K
N
--------
L
R
S
R
--------------
L
M
A
T
Q
--------------------------------------------
A
W
L
E
A
R
--
L
K
G
E
E
L
P
K
P
EGL
L
T
Q
N
E
E
L
W
------------
E
P
L
Y
A
C
Y
Q
-----
S
L
------
Q
A
----
C
G
M
G
I
I
A
N
----------
G
D
L
L
D
T
----
L
R
R
V
K
C
F
G
----------------------------
V
P
L
V
-----------------
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
--
G
E
L
T
R
Y
L
G
I
-
G
D
Y
E
S
W
S
E
A
D
K
Q
A
F
--
L
I
R
E
---
L
--
N
-
S
K
R
-
P
--------
L
L
P
R
N
W
Q
P
S
A
--
E
T
R
E
----
V
L
D
T
C
---
Q
V
I
-
A
E
A
-
P
--
Q
G
S
I
--
A
A
Y
V
I
----
S
--
M
A
K
T
P
S
D
V
L
A
V
H
--------------
L
L
L
K
E
A
---------
G
--------
I
G
-
F
A
-----------
M
P
----
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
----
R
G
L
I
---
Q
G
K
Q
M
V
--
M
I
G
Y
S
D
S
A
K
D
A
G
V
-------
M
A
A
S
W
A
-
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
---
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
A
P
--------
A
--
H
A
A
L
L
S
Q
P
--------
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
-----
P
E
I
-------------------------
T
V
S
S
L
-
S
L
Y
T
G
A
I
L
E
-------
A
N
L
L
P
P
---
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
--
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
---------------
F
R
S
A
T
P
-------------
E
Q
E
L
G
K
L
P
L
G
S
R
P
A
K
-----------------------
V
E
S
-----
L
R
A
I
P
W
I
F
A
W
T
-----
Q
N
R
L
M
L
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
---
D
G
K
Q
S
E
L
----
E
A
M
C
R
D
W
-----------
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
-
D
-
Q
-
R
L
V
D
K
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
---
E
D
-------
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
----
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
--
R
S
-
R
Q
A
E
K
E
----------------------
G
--------
Q
E
-
P
-----
D
P
R
V
E
Q
A
L
M
-------
V
T
I
A
-
G
I
A
A
G
M
---------
R
N
T
G
-----------------------------
43
Fugue
50.31
17%
-35
- C3 -
3ODM
5
CAPPA_CLOPE
A:
[24-560]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
------------
I
P
C
S
M
M
T
Q
HPDNV
E
T
------
Y
I
----
S
I
Q
Q
E
P
A
E
----------
A
I
K
G
L
T
----
P
Q
D
K
G
G
L
G
----------------------------
I
E
E
V
-----------------
M
I
D
F
-
E
G
K
L
T
P
Y
H
Q
T
--
S
Q
I
A
L
G
L
I
-----------
S
N
G
I
I
--
P
G
K
D
---
V
--
R
-
V
T
P
-
R
--------
I
P
N
A
N
K
E
S
V
F
--
R
Q
L
M
S
I
M
S
I
I
E
T
N
---
V
Q
S
-
K
E
L
T
G
--
T
P
A
I
--
S
E
V
V
V
----
P
--
M
I
E
T
G
K
E
I
S
E
F
Q
--------------
D
R
V
N
S
V
---------
V
--------
D
M
-
G
N
K
N
YK
T
K
L
D
L
N
S
V
R
----
I
I
P
L
V
E
D
V
P
A
L
A
N
I
D
R
I
L
D
E
H
Y
E
I
E
K
S
----
K
G
---
H
I
L
K
D
L
R
I
--
M
I
A
R
S
D
T
A
M
S
Y
G
L
-------
I
S
G
V
L
S
-
V
L
M
A
V
D
G
A
Y
K
W
G
E
K
H
G
V
---
T
I
S
P
I
L
G
C
G
S
L
P
F
R
G
H
------------------------------------
F
S
E
E
N
I
D
E
I
L
A
T
Y
S
G
I
KTFTF
Q
S
A
-------------------------
L
R
Y
D
H
-
G
E
E
A
T
K
H
A
V
R
E
----
L
K
E
K
I
A
Q
SKP
R
N
F
S
E
E
D
K
D
L
M
K
E
F
I
G
I
C
--
S
K
H
Y
L
----
Q
T
F
L
K
V
I
D
T
V
S
F
---------------
V
S
D
F
I
P
KNRDRLTAN
L
D
N
V
A
D
L
V
K
D
E
V
L
K
Q
E
I
L
S
I
D
N
S
-----------------
K
E
Y
A
V
-----
P
R
A
I
S
F
T
G
A
M
Y
-----
T
L
G
-
M
P
P
E
L
M
G
M
G
R
A
L
N
E
I
K
T
K
Y
---
G
Q
E
G
I
----
D
K
L
L
E
I
Y
-----------
P
I
L
R
K
D
L
A
F
A
A
R
F
A
N
G
G
V
S
K
K
I
I
D
E
-
E
-
A
-
R
Q
E
Y
K
E
D
M
K
Y
V
N
E
I
L
N
---------------------
L
G
L
D
---
Y
D
F
L
N
E
N
E
----
F
Y
H
T
L
L
K
T
T
K
P
I
I
M
H
L
M
G
L
E
E
N
V
M
R
N
S
T
E
-
E
---------------------------
L
--------
K
I
-
L
-----
N
E
W
I
V
R
M
G
K
-------
V
R
-
G
-
S
I
G
---------------------------------------------
44
Fugue
48.01
15%
-28
- C2 -
3UGM
-
PTHX1_XANOP
A:
[169-1048]
--------------------------------------------------
K
P
K
V
R
E
L
V
A
H
I
V
A
L
--
S
Q
H
P
A
A
L
G
---------
T
V
A
V
T
Y
Q
--------
H
------
I
I
T
A
---------
L
A
----------------------------
T
H
E
D
I
V
G
V
G
K
Q
---------
W
S
G
A
R
A
L
--
E
A
L
L
T
D
A
G
E
L
R
G
P
P
L
Q
--
L
D
T
G
Q
L
V
K
I
A
K
R
GG-----------
V
T
-------------
A
M
E
------------
A
-----
V
H
A
S
R
N
A
L
T
P
L
--------
N
L
T
P
--------------
A
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
Q
R
L
--
L
P
V
-
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
SHD-----
G
G
K
Q
A
L
-------
E
-----
T
--
M
Q
----
R
L
L
P
V
L
C
Q
A
H
G
L
P
------
P
D
Q
V
V
A
I
A
S
--------
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
-
P
V
L
C
Q
A
--
H
G
L
T
P
D
-
Q
V
--
V
A
I
-
A
-
S
--------------
H
G
G
G
K
Q
A
L
E
T
V
Q
R
--
L
L
P
V
L
C
---
Q
---------------------
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
H
D
G
G
K
Q
----
A
--
L
---
E
T
V
Q
R
L
---
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
-----
A
I
A
S
-------
N
G
G
G
---
K
Q
-----
A
L
E
T
--------
V
Q
R
L
--------------
L
--
P
V
L
C
Q
A
------
H
-----
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
K
Q
A
L
E
T
--
V
Q
R
L
L
P
V
L
C
Q
A
HG
L
T
P
D
Q
V
V
A
----
I
A
S
H
D
G
G
K
------------
Q
A
L
E
T
V
Q
R
-----
L
L
------
P
V
----
L
C
Q
T
H
G
L
T
----------
P
A
Q
V
V
A
----
I
A
S
H
D
G
G
K
----------------------------
Q
A
L
E
-----------------
T
V
Q
Q
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
A
T
V
Q
R
L
L
P
--
V
L
C
Q
AHG
L
--
T
P
D
Q
V
-
V
--------
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
---
H
G
L
T
P
D
Q
V
V
--
A
I
A
S
--
N
G
G
G
K
----
Q
--
A
L
E
T
V
Q
R
L
--
L
P
--------------
V
L
C
Q
A
H
---------
G
--------
L
-------------
T
Q
V
Q
----
V
V
A
I
A
S
N
I
----
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
----
L
C
Q
A
H
G
L
T
P
A
Q
V
V
--
A
I
A
S
H
D
G
---------------
G
K
Q
A
-
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
-----
G
K
Q
--------
A
--
L
E
T
V
Q
R
L
L
--------
P
G
-----
L
T
Q
E
Q
V
V
A
I
A
S
N
N
G
G
K
-----
Q
A
L
-------------------------
E
T
V
Q
R
-
L
L
P
V
L
C
Q
A
H
G
L
----
T
P
D
Q
V
V
A
---
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
--
P
V
L
C
Q
----
A
----------
H
---------------
G
L
T
P
A
Q
-------------
V
V
A
I
A
S
-
N
I
G
G
K
Q
A
L
E
T
V
Q
-----------------
R
L
L
P
V
-----
L
C
Q
D
---------------------
H
G
L
T
L
A
Q
V
V
A
I
A
S
N
-
I
G
G
K
Q
A
L
----
E
T
V
Q
R
L
L
-----------
P
V
L
C
Q
G
L
T
Q
D
Q
V
V
A
I
A
S
N
I
G
--------
G
-
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
---
L
T
-------
P
D
Q
V
V
A
I
A
S
N
---
I
G
----
G
K
----
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
L
D
Q
V
V
--
A
I
-
A
---------------------------
S
--------
N
G
-
G
-----
K
Q
A
L
E
T
V
Q
R
L
------
L
P
V
L
-
C
Q
D
H
G
L
TPDQVVAIA
S
N
S
G
-----------------------------
45
Fugue
47.73
18%
-43
* C5 *
4ZHJ
-
?
A:
[20-1350]
-----------------------
H
M
F
T
N
V
K
S
T
I
R
R
V
D
P
EA
L
N
G
R
Q
L
L
K
V
V
Y
V
V
L
E
S
Q
Y
Q
S
A
L
S
A
A
V
R
N
I
N
R
T
N
S
---------
S
L
A
I
Q
L
T
G
Y
L
IEELP
E
------
N
Y
A
N
---------
F
K
H
D
---------
V
S
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AN
L
F
I
A
S
LIFI
E
D
L
A
D
K
V
V
E
A
V
T
P
Y
RDNLD
A
A
I
V
F
P
S
M
P
Q
V
--
M
R
L
N
K
M
G
S
F
S
M
A
Q
L
G
F
Q
D
A
M
L
K
L
L
R
T
L
P
T
V
-------------
L
K
-------------
Y
L
P
------------------
V
E
K
A
Q
D
A
R
N
F
M
--------
L
S
F
Q
--------------
Y
W
L
G
G
S
-
Q
E
N
L
E
N
F
L
L
M
L
T
D
K
Y
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P
D
L
G
L
D
V
Y
P
D
M
--
G
I
W
H
PLSMQMFEN
V
K
D
Y
L
E
W
Y
N
Q
RPDIS
E
-----
D
--
L
K
DPL
A
P
C
I
G
L
I
M
Q
R
T
H
L
V
T
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D
---
D
A
H
Y
V
G
M
V
Q
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L
------
E
A
M
G
A
R
V
I
C
V
F
S
G
G
L
-
D
F
S
K
P
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--
N
E
Y
F
W
D
-
K
S
--
E
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L
-
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-
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VD
A
V
V
S
LT
G
F
A
L
V
G
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D
H
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R
A
I
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S
L
K
K
L
--
N
R
P
Y
M
C
---
A
---------------------
L
P
L
V
F
Q
H
P
I
Q
V
A
L
Q
I
A
I
P
E
L
D
GAI
E
--
P
---
I
I
L
I
A
L
---
Q
D
R
L
E
A
I
A
Q
R
A
M
K
W
A
N
-----
L
R
-
K
-------
K
P
K
L
---
D
K
K
V
A
I
T
V
F
S
F
--------
P
P
D
K
GNVGTAAYLD
V
F
G
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I
Y
E
V
M
K
G
L
Q
G
N
GYDV
Q
-----
D
L
P
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S
A
K
E
L
M
E
A
V
I
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D
A
Q
A
Q
Y
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P
E
L
N
I
A
H
R
M
S
V
--
E
Q
Y
E
R
L
T
P
----
Y
S
V
R
L
E
E
N
WGKPPGHLNSDG
Q
N
L
L
I
Y
G
K
-----
E
F
GN
V
F
I
G
V
Q
PTFG
Y
E
G
D
P
M
R
L
L
F
S
R
S
A
S
P
H
H
G
F
A
A
Y
Y
----
T
Y
L
N
H
I
W
K
AD
A
V
L
H
F
GTHGSLEFMPGDNLIGT
I
P
N
L
Y
Y
Y
A
ANN
P
S
E
A
T
I
A
K
R
RGYAS
T
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Y
L
T
P
P
A
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A
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L
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--
K
G
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L
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D
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R
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--
I
V
N
T
---
I
--
M
-
D
Q
A
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NLDQD
V
N
L
P
D
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N
A
E
E
M
--
D
Q
G
Q
R
D
T
I
V
G
S
V
Y
---
R
K
L
-
M
E
-
I
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--
S
R
L
L
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L
H
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I
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Q
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P
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--
A
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A
I
A
T
L
V
N
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A
S
LDREDEGIWA
L
P
T
L
I
A
E
S
I
---------
G
RN------
M
E
-
E
I
Y
R
-------
N
S
D
K
G---
I
L
A
D
V
E
L
L
Q
D
I
T
L
A
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R
A
A
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A
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DG
R
V
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F
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S
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K
A
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E
E
K
L
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L
F
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Y
L
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F
C
L
E
Q
V
C
A
D
N
E
F
G
G
L
---
L
Q
A
L
-
E
G
E
Y
V
L
P
G
P
G
G
D
P
IRNPNVLP
T
--
G
K
N
I
H
A
L
D
--------
P
Q
S
I
P
T
L
A
A
V
Q
S
A
K
V
V
V
D
R
L
L
E
R
-----
Q
R
A
E
N
GGNYPE
T
I
A
S
V
L
W
G
T
D
N
I
K
T
YG
E
S
L
A
Q
I
-
M
W
M
V
G
A
K
P
V
P
D
ALGR
V
N
K
I
E
L
V
---
P
L
E
E
L
G
-
R
P
R
I
D
V
V
V
N
C
S
---
G
V
F
R
----
D
L
F
I
N
Q
M
N
L
L
D
Q
A
V
K
L
A
A
E
ADEPLEMN
F
V
R
K
H
A
-------------
L
E
Q
A
E
E
M
G
I
G
V
R
E
A
A
T
R
I
F
-----------------
S
N
A
S
G
SYSSN
V
N
L
A
V
E
N
S
S
W
E
D
E
S
E
L
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E
M
Y
L
K
R
K
S
F
A
F
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S
D
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P
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M
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N
-
R
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L
K
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A
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L
DSSEISLTDVS
H
Y
F
D
S
D
P
T
K
L
I
S
T
L
R
D
D
G
K
A
P
A
A
Y
I
-
A
D
T
-
T
T
A
N
A
Q
V
R
T
L
S
E
T
V
R
L
D
A
R
T
KL
L
N
-------
P
K
W
Y
E
G
M
L
S
H
G
Y
-
E
G
V
R
E
L
S
K
----
R
L
V
N
T
M
G
W
S
A
T
A
G
A
V
D
N
W
V
Y
E
D
A
N
S
--
T
F
I
K
---------------------------
D
--------
E
E
-
M
-----
C
K
R
L
M
D
L
N
P
-------
N
S
F
R
-
R
M
V
S
T
L
---------
L
E
V
N
G
R
GY
W
E
T
S
D
E
N
L
E
R
L
Q
E
L
Y
Q
E
V
E
D
R
I
EGV
48
Fugue
46.08
17%
-18
- C1 -
4MT1
-
?
A:
[2-1040]
A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
L
P
V
S
Q
Y
P
-----
S
V
A
A
P
T
I
-
T
L
H
A
I
Y
P
G
A
S
A
Q
V
M
E
G
--
S
V
L
S
V
I
E
R
N
MNGVEGLD
Y
M
S
T
S
A
D
--------
S
------
S
G
S
G
S
--------
V
S
L
T
---------
F
T
-------------
P
D
T
D
E
N
L
A
Q
V
E
V
Q
---------
N
K
L
S
E
V
L
--
S
T
L
P
A
T
V
Q
-
Q
Y
G
V
T
V
S
K
A
-
R
S
N
F
L
M
I
V
M
L
S
-------------
S
D
-------------
V
Q
S
------------
T
-----
E
E
M
N
D
Y
A
Q
R
N
V
VPELQRIE
G
V
G
Q
--------------
V
R
L
F
G
A
-
Q
R
A
M
R
I
W
V
D
P
K
K
L
Q
N
--
Y
N
L
---
S
F
A
D
V
G
S
A
L
S
------------
A
Q
N
I
Q
I
-------
S
A
G
S
I
G
S
--
L
P
----
A
V
R
G
Q
T
V
T
A
T
V
T
A
Q
G
Q
L
G
T
A
E
E
F
G
N
V
-------------
I
L
R
A
N
T
D
G
S
N
I
Y
-
L
K
D
V
A
K
--
V
G
L
G
M
E
-
D
Y
--
S
S
S
-
T
-
R
L
NG
V
N
T
T
-
G
M
A
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M
L
S
N
S
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N
A
M
A
T
A
K
A
V
K
E
R
L
A
V
L
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---
K
Y
FPQG
M
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W
K
T
PYDT
S
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F
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S
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H
T
L
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A
M
V
L
V
F
V
V
M
Y
----
L
--
F
L
QN
I
R
Y
T
L
I
---
P
T
I
V
V
P
I
S
L
L
G
G
F
A
F
I
-----
S
Y
-
M
-------
G
M
S
I
---
N
V
-----
L
T
M
F
A
M
I
L
V
I
GI
V
V
D
D
--------------
A
I
V
V
V
E
N
V
E
------
R
I
M
A
G
E
G
L
P
P
K
E
A
T
K
K
A
M
G
Q
I
S
G
A
V
I
G
--
I
T
A
V
L
I
S
V
F
V
P
--
L
A
---
M
F
S
----
G
A
A
G
N
I
Y
K
------------
Q
F
A
L
T
M
A
S
-----
S
I
------
A
F
----
S
A
F
L
A
L
T
-------------
L
T
P
A
----
L
C
A
T
G
F
F
G
----------------------------
W
F
N
K
-----------------
K
F
D
-
S
W
T
H
G
Y
E
G
R
V
A
--
K
V
L
R
K
T
F
R
M
M
V
V
Y
I
G
L
A
V
V
G
V
F
L
F
M
R
L
P
T
S
---
F
L
P
T
-
E
D
Q
G
F
--------
V
M
V
S
V
Q
L
P
A
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--
A
T
K
E
R
T
D
A
T
L
A
Q
V
---
T
Q
L
-
A
K
S
I
P
EI
E
N
I
I
--
T
V
S
G
F
----
S
--
F
S
G
S
G
Q
N
M
A
M
G
F
--------------
A
I
F
K
D
W
---------
N
-----------
E
R
T
A
-------
S
G
S
D
----
A
V
A
V
A
G
K
L
T
G
M
M
M
G
T
--
L
K
D
G
F
G
I
A
V
V
----
P
P
P
I
L
E
L
G
S
G
L
S
I
--
N
L
--
Q
D
R
N
N
T
G
------------
H
T
A
-
L
L
A
K
R
N
E
L
I
Q
K
M
R
A
S
G
L
------
F
D
P
S
T
V
R
A
G
G
L
E
D
S
P
--------
Q
--
L
K
I
D
I
N
R
A
A
A
A
A
QGIS
F
A
D
I
R
T
A
L
A
S
A
L
S
S
S
Y
V
S
D
F
P
N
Q
-----
G
R
L
-------------------------
Q
R
V
M
V
-
Q
A
D
E
D
A
R
M
Q
P
A
----
D
I
L
N
L
T
V
---
P
N
K
-
S
G
V
A
V
P
L
S
T
I
A
T
V
S
W
E
N
G
T
E
Q
----
S
V
R
F
N
G
--
Y
P
S
M
---------------
K
L
S
A
S
P
-------------
A
T
G
V
S
T
G
Q
--
A
M
E
A
V
Q
K
M
V
-----------------
D
E
L
G
G
-----
G
Y
S
F
E
W
G
G
Q
S
S
-----
E
E
A
------
K
G
G
S
Q
T
L
I
L
Y
G
L
A
V
-
A
A
V
F
L
V
L
----
A
A
L
Y
E
S
W
-----------
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
G
R
N
-
L
-
F
-
E
G
L
L
G
S
V
P
S
F
A
N
D
I
Y
F
Q
V
G
---
F
V
T
V
M
G
L
S
A
K
N
A
I
L
I
I
E
F
A
---
K
D
L
Q
A
Q
G
K
S
A
V
E
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
--
P
L
-
Y
---------------------------
I
--------
A
A
G
A
-----
S
S
A
S
Q
R
A
I
G
-------
T
T
V
F
W
G
M
L
V
G
T
---------
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F---------------
22
HHSearch
45.08
19%
-37
- C3 -
3ODM
4
CAPPA_CLOPE
A:
[135-540]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
--
T
P
A
I
--
S
E
V
V
V
----
P
--
M
I
E
T
G
K
E
I
S
E
F
Q
--------------
D
R
V
N
S
V
---------
V
D
M
G
N
K
N
YK
T
K
--
L
D
L
-------
N
S
V
R
----
I
I
P
L
V
E
D
V
P
A
L
A
N
I
D
R
I
L
D
E
H
Y
E
I
E
K
S
----
K
G
H
I
L
---
K
D
L
R
I
--
M
I
A
R
S
D
T
A
M
S
Y
G
L
-------
I
S
G
V
L
S
-
V
L
M
A
V
D
G
A
Y
K
W
G
E
K
H
G
V
---
T
I
S
P
I
L
G
C
G
S
L
P
F
R
G
H
F
S
--------
E
EN
I
D
E
I
L
A
T
Y
--------
S
G
----
I
K
T
F
T
F
Q
S
---
A
L
R
Y
D
H
-----
G
E
E
-------------------------
A
T
K
H
A
-
V
R
E
L
K
E
K
I
A
Q
S
-----
K
P
R
--
N
-----
F
S
E
E
D
K
D
L
M
K
E
F
I
G
I
C
--
S
K
H
Y
L
Q
T
F
L
K
V
I
-
D
T
V
S
F
V
S
D
---------------
F
I
P
K
-
N
-------------
R
D
R
L
T
------------
A
N
L
D
N
V
A
D
L
VKD
E
V
L
K
Q
E
I
L
S
I
D
N
SK---
E
Y
A
V
P
R
A
I
S
F
T
G
A
M
--
Y
T
L
G
M
P
P
E
L
M
G
M
G
R
A
L
N
E
I
K
T
K
Y
G
Q
E
G
I
D
K
L
----
L
E
I
Y
--------------
P
I
L
------------
R
K
D
L
A
F
A
A
R
F
-
A
-
N
G
G
V
S
K
---
K
I
I
D
E
E
A
R
Q
E
Y
K
---
E
D
-------
M
K
Y
V
N
E
I
L
N
L
GLD
Y
D
F
L
N
E
N
E
----
F
Y
H
T
L
L
K
T
T
K
P
I
I
M
H
L
M
G
L
E
E
N
V
M
R
--
N
S
-
T
---------------------------
E
--------
E
L
-
K
-----
I
L
N
E
W
I
V
R
M
-------
G
K
V
R
-
G
S
I
G
--------------------------------------------
8
PsiBlast_PDB
43.99
23%
-18
- C3 -
3ODM
1
CAPPA_CLOPE
A:
[98-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
---
V
--
R
-
V
T
P
-
R
--------
I
P
N
A
N
K
E
S
V
F
--
R
Q
L
M
S
I
M
S
I
I
E
T
N
---
V
Q
S
-
K
E
L
T
G
--
T
P
A
I
--
S
E
V
V
V
----
P
--
M
I
E
T
G
K
E
I
S
E
F
Q
--------------
D
R
V
N
S
V
V
D
M
G
N
K
N
YK
T
--------
K
L
-
D
L
N
S
-------
V
R
I
------
I
P
L
V
E
D
V
P
A
L
A
N
I
D
R
I
L
D
E
H
Y
E
I
E
K
S
----
K
G
H
I
L
K
D
---
L
R
I
--
M
I
A
R
S
D
T
A
M
S
Y
G
L
-------
I
S
G
V
L
S
-
V
L
M
A
V
D
G
A
Y
K
W
G
E
K
H
G
V
---
T
I
S
P
I
L
G
C
G
S
L
P
F
R
G
H
F
S
--------
E
--
E
N
I
D
E
I
L
A
--------
T
Y
S
G
I
K
T
F
T
F
Q
S
A
L
R
Y
D
H
G
E
E
A
T
-----
K
H
A
-------------------------
V
R
E
L
K
-
E
K
I
A
Q
S
K
P
R
N
F
----
S
E
E
D
K
D
L
---
M
K
E
F
I
G
I
C
S
K
H
Y
L
Q
T
F
L
K
--
V
I
D
T
V
----
S
F
V
S
D
F
I
P
K
N
R
D
---------------
R
L
T
A
N
L
-------------
D
N
V
A
D
L
V
K
D
E
V
L
K
Q
E
I
L
S
I
-----------------
D
N
S
K
E
-----
Y
A
V
P
R
A
I
S
F
T
G
-----
A
M
Y
T
L
G
M
P
P
E
L
M
G
M
G
R
A
L
N
E
I
K
T
-
K
Y
G
Q
E
G
I
----
D
K
L
L
E
I
Y
-----------
P
I
L
R
K
D
L
A
F
A
A
R
F
A
N
G
G
V
S
K
K
I
I
D
E
-
E
-
A
-
R
Q
E
Y
K
E
D
M
K
Y
V
N
E
I
L
N
L
G
L
---
D
Y
-------
D
F
L
N
E
N
E
F
Y
H
---
T
L
L
K
T
T
K
P
----
I
I
M
H
L
M
G
L
E
E
N
V
M
R
N
S
T
E
E
L
K
I
L
N
E
--
W
I
-
V
---------------------------
R
--------
M
G
-
K
-----
V
R
G
S
I
G
---------------------------------------------------------------
50
Fugue
38.85
10%
-28
- C5 -
1I7W
5
CTNB1_MOUSE
C:
[10-530]
-----------------------------------------------------------
Q
D
D
A
E
--
L
A
T
R
A
I
P
E
---------
L
T
K
L
L
N
D
--------
E
------
D
Q
V
V
---------
V
N
K
A
---------
A
V
-------------
M
V
H
Q
L
-----
S
K
K
---------
E
A
S
R
H
A
I
--
M
R
S
P
Q
M
V
S
A
I
V
R
T
M
Q
N
T
N
-
D
V
E
T
A
R
C
T
A
G
T
-------------
L
H
-------------
N
L
S
------------
H
-----
H
R
E
G
L
L
A
I
F
K
S
--------
G
G
I
P
--------------
A
L
V
K
M
L
-
G
S
P
V
D
S
V
L
F
Y
A
I
T
T
L
--
H
N
L
-
L
L
H
Q
E
G
A
K
M
A
V
R
------------
L
A
G
----------------------------
G
L
Q
K
M
V
A
L
L
N
K
T
N
V
K
F
L
A
I
T
T
D
C
L
Q
I
L
A
YGN
Q
E
S
K
L
I
I
L
A
S
G
G
P
Q
A
L
V
-
N
I
M
R
T
Y
--
T
Y
E
K
L
L
-
W
T
--
T
S
R
-
V
-
L
--------
K
V
L
S
V
C
S
S
N
K
P
A
I
V
E
A
G
G
M
--
Q
A
L
G
L
H
L
TD
P
---------------------
S
Q
R
L
V
Q
N
C
L
W
T
L
R
N
L
S
D
A
A
T
----
K
--
Q
---
E
G
M
E
G
L
---
L
G
T
L
V
Q
L
L
G
S
D
D
------------------------------------
I
N
--------
V
V
T
C
--------------
A
A
G
I
L
S
N
L
T
------
C
-----
N
N
Y
K
N
K
M
M
V
C
Q
V
G
G
I
E
A
L
V
R
T
--
V
L
R
A
----------------------
G
D
R
E
D
I
T
------------
E
P
A
I
C
A
L
R
-----
H
L
------
T
S
----
R
H
Q
E
---
A
----------
E
M
A
Q
N
A
----
V
R
L
H
Y
G
L
P
----------------------------
V
V
V
K
-----------------
L
L
H
P
P
S
H
W
P
L
I
K
A
T
V
--
G
L
I
R
N
L
A
L
C
P
A
N
H
A
P
L
R
E
Q
G
A
I
P
R
--
L
V
Q
L
---
L
--
V
-
R
A
H
-
Q
--------
D
T
Q
R
R
T
V
R
M
E
--
E
I
V
E
G
C
T
G
A
L
H
I
L
A
RD
V
H
N
-
R
I
V
I
R
--
G
L
N
T
--
I
P
L
F
V
----
Q
L
L
Y
S
P
I
E
N
I
Q
R
V
A
A
--------------
G
V
L
C
E
L
---------
A
--------
Q
D
-
K
E
A
A
-------
E
A
I
E
A
E
GA
T
A
P
L
T
E
L
L
H
S
R
N
E
G
V
A
T
Y
A
A
A
V
L
F
R
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
36.24
22%
11
- C3 -
3GG8
-
?
A:
[222-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
--
N
F
I
A
A
----
S
--
F
V
Q
S
A
D
D
V
R
Y
I
R
--------------
G
L
L
G
P
R
---------
G
----------------------
R
H
I
R
----
I
I
P
K
I
E
N
V
E
G
L
V
N
F
D
E
I
L
A
E
--------------------
A
D
G
I
--
M
I
A
R
G
D
L
G
M
E
I
P
P
-------
E
----
K
-
V
F
L
A
Q
K
M
M
I
A
K
C
N
V
V
G
K
---
P
V
I
T
A
T
Q
M
L
E
S
M
I
K
N
P
R
P
--------
T
--
R
A
E
A
A
D
V
A
--------
N
A
V
L
D
G
T
D
C
V
M
L
S
G
E
T
A
N
G
E
F
P
V
-----
I
T
V
-------------------------
E
T
M
A
R
-
I
C
Y
E
A
E
T
C
V
D
Y
----
P
A
L
Y
R
A
M
---
C
L
A
V
P
P
P
I
S
T
Q
E
A
V
A
R
A
A
--
V
E
T
A
E
----
C
V
N
A
A
I
I
L
A
L
T
E
---------------
T
G
Q
T
A
R
-------------
L
I
A
K
Y
R
P
M
Q
P
I
L
A
L
S
A
S
E
S
-----------------
T
I
K
H
L
-----
Q
V
I
R
G
V
T
T
M
Q
V
-----
P
S
G
T
D
H
V
I
R
N
A
I
V
V
A
K
E
R
E
L
V
T
E
-
G
E
S
I
V
A
V
----
H
G
M
S
S
N
L
-----------
L
K
V
L
T
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
35.64
18%
-15
* C4 *
2BVL
8
TOXB_PEPDI
A:
[1-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
L
V
N
R
K
Q
L
--
E
K
M
A
N
V
---
R
---------------------
F
R
T
Q
E
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
----
M
--
S
---
E
N
--
T
V
---
V
E
K
Y
L
K
L
K
D
I
N
S
L
T
D
I
-----
C
I
-
D
-------
T
Y
K
K
SGR
N
K
-----
A
L
K
K
--------
F
K
E
Y
--------------
L
V
T
E
V
L
E
L
K
------
N
N
----
N
L
T
P
V
E
K
N
L
H
F
V
W
I
G
G
Q
I
N
D
T
--
A
I
N
Y
I
N
Q
W
K
D
V
--
N
S
D
Y
N
V
N
V
----
F
Y
D
S
N
A
F
L
--------------
I
N
T
L
K
K
-----
T
V
------
V
E
----
S
A
I
N
D
T
L
E
----------
S
F
R
E
N
L
NDPR
F
D
Y
N
K
F
F
R
----------------------------
K
R
M
E
-----------------
I
I
Y
D
K
Q
K
N
F
I
N
Y
Y
K
A
--
Q
R
E
E
N
P
E
L
I
I
D
D
I
V
K
T
Y
L
S
N
E
Y
S
K
--
E
I
D
E
---
L
--
N
-
T
Y
I
-
E
--------
E
S
L
N
K
I
T
Q
N
S
--
G
N
D
V
R
N
F
G
E
F
K
N
G
----
E
S
-
F
N
L
Y
E
--
Q
E
L
V
--
E
R
W
---------
N
L
A
A
A
S
D
I
L
R
I
S
--------------
A
L
K
E
I
G
---------
G
--------
M
Y
L
D
V
D
M
-------
L
P
G
I
----
Q
P
D
L
F
E
S
I
E
K
P
S
S
V
T
V
D
F
W
E
M
T
K
L
E
A
I
----
M
K
Y
K
E
Y
I
P
E
Y
T
S
E
--
H
F
D
M
L
D
----------------------
E
E
V
Q
S
S
F
E
S
V
L
A
S
K
S
D
---
K
S
E
I
F
----
S
S
L
G
D
M
E
A
S
--------
P
--
L
E
V
-------------------
K
I
A
F
N
S
K
G
I
I
N
Q
G
L
I
S
V
-----
K
D
S
-------------------------
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
L
----
N
N
S
L
N
P
A
---
I
S
E
D
N
D
F
N
T
T
T
N
T
F
I
D
S
I
--
M
A
E
----------
A
N
A
D
N
G
R
F
---------------
M
M
E
L
G
K
-------------
Y
L
R
V
-----
G
F
F
P
D
V
-
K
T
T
-----------------
I
N
L
S
G
-----
P
E
A
Y
A
A
A
Y
--------
Q
D
L
L
M
F
K
E
----
G
S
M
N
I
H
L
I
E
A
D
-
L
R
N
F
E
I
S
----
K
T
N
I
S
Q
S
T
E
---------
Q
E
M
A
S
L
W
S
F
D
D
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
-
F
-
E
-
G
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
34.34
21%
1
- C3 -
3T05
-
KPYK_STAAR
A:
[206-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
--
D
F
I
A
A
----
S
--
F
V
R
R
P
S
D
V
L
E
I
R
--------------
E
I
L
E
E
Q
---------
K
----------------------
A
N
I
S
----
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
--------------------
S
D
G
L
--
M
V
A
R
G
D
M
G
V
E
I
P
P
-------
E
----
K
-
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
---
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
--------
T
--
R
A
E
A
S
D
V
A
--------
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
-----
E
A
V
-------------------------
K
T
M
R
N
-
I
A
V
S
A
E
A
A
Q
D
Y
----
K
K
L
L
S
D
R
---
T
K
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
--
T
A
L
N
L
----
N
V
K
A
I
V
A
A
T
E
S
G
---------------
S
T
A
R
T
I
-------------
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
-----------------
R
Q
C
S
I
-----
V
W
G
V
Q
P
V
V
K
K
G
-----
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
-
G
D
L
I
I
I
T
----
A
G
V
P
T
G
E
-----------
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
-
S
-
V
-
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
---
D
K
-------
V
I
V
T
N
S
I
D
E
T
---
F
V
P
Y
V
E
K
A
----
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
--
V
V
-
G
---------------------------
V
--------
E
K
-
A
-----
V
K
N
I
S
N
N
V
L
-------
V
T
I
D
-
A
A
Q
G
K
I
---------
F
E
G
Y
-----------------------------
27
HHSearch
34.12
22%
18
- C3 -
3KHD
-
?
A:
[230-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
--
N
F
I
A
A
----
S
--
F
I
Q
S
A
D
D
V
R
L
I
R
--------------
N
L
L
G
P
R
---------
G
----------------------
R
H
I
K
----
I
I
P
K
I
E
N
I
E
G
I
I
H
F
D
K
I
L
A
E
--------------------
S
D
G
I
--
M
I
A
R
G
D
L
G
M
E
I
S
P
-------
E
----
K
-
V
F
L
A
Q
K
L
M
I
S
K
C
N
L
Q
G
K
---
P
I
I
T
A
T
Q
M
L
E
S
M
T
K
N
P
R
P
--------
T
--
R
A
E
V
T
D
V
A
--------
N
A
V
L
D
G
T
D
C
V
M
L
S
G
E
T
A
G
G
K
F
P
V
-----
E
A
V
-------------------------
T
I
M
S
K
-
I
C
L
E
A
E
A
C
I
D
Y
----
K
L
L
Y
Q
S
L
---
V
N
A
I
E
T
P
I
S
V
Q
E
A
V
A
R
S
A
--
V
E
T
A
E
----
S
I
Q
A
S
L
I
I
A
L
T
E
---------------
T
G
Y
T
A
R
-------------
L
I
A
K
Y
K
P
S
C
T
I
L
A
L
S
A
S
D
S
-----------------
T
V
K
C
L
-----
N
V
H
R
G
V
T
C
I
K
V
-----
G
S
F
Q
G
T
D
I
V
I
R
N
A
I
E
I
A
K
Q
R
N
M
A
-
K
V
G
D
S
V
I
----
A
I
H
G
K
E
E
-----------
V
S
G
G
T
N
L
M
K
V
V
Q
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
33.78
18%
-6
- C3 -
3GR4
4
KPYM_HUMAN
A:
[255-360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
--
D
M
V
F
A
----
S
--
F
I
R
K
A
S
D
V
H
E
V
R
--------------
K
V
L
G
E
K
---------
G
----------------------
K
N
I
K
----
I
I
S
K
I
E
N
H
E
G
V
R
R
F
D
E
I
L
E
A
--------------------
S
D
G
I
--
M
V
A
R
G
D
L
G
I
E
I
P
A
-------
E
----
K
-
V
F
L
A
Q
K
M
M
I
G
R
C
N
R
A
G
K
---
P
V
I
C
A
T
Q
M
L
E
S
M
I
K
K
P
R
P
--------
T
--
R
A
E
G
S
D
V
A
--------
N
A
V
L
D
G
A
D
C
I
M
L
S
G
E
T
A
K
G
D
Y
P
L
-----
E
A
V
-------------------------
R
M
Q
H
L
-
I
A
R
E
A
E
A
A
I
Y
H
----
L
Q
L
F
E
E
L
---
R
R
L
A
P
I
T
S
D
P
T
E
A
T
A
V
G
A
--
V
E
A
S
F
----
K
C
C
S
G
A
I
I
V
L
T
K
---------------
S
G
R
S
A
H
-------------
Q
V
A
R
Y
R
P
R
A
P
I
I
A
V
T
R
N
P
Q
-----------------
T
A
R
Q
A
-----
H
L
Y
R
G
I
F
P
V
L
C
-----
K
D
P
V
Q
E
A
W
A
E
D
V
D
L
R
V
N
F
A
M
N
V
G
-
K
A
R
G
F
F
K
----
K
G
D
V
V
I
V
-----------
L
T
G
W
R
P
G
S
G
F
T
N
T
M
R
V
V
P
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------