@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0805: (2015-12-03 )
MKNYRKLIVLLLLTFFVIFMGAYAYTHIVEKRSLTSNTIEKTLPVVNQIKPQTIKEYQNYLTKVAKRNVLPVDIPQALNNEKVEITATDGMQTFTWNDKNNPKQKVIFYVHGGSYIHQASELQYIFVNKLAKKLDAKVVFPIYPKAPTYNYSDAIPKIKKLYQNTLASVTSPKQIILVGESAGGGLALGLADNLVTEHIKQPKEIILISPWLDIATNNPKIEKVQKKDPLLKAWQLQQVAPYWANGKKNFKNPQVSPLYSSQFNKMAPISFFIGTHDIFYPDNQLLHQKLAKENIKHHYIVGQKMNHVYPVLPIPEAETAFKQMLKIINH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.-.......-80........90........100..---.....110.......120.......130.......140-.......150.......160......-----.-----170.......180.......190.......200.......210.......220...-.....230..--.--....240.......250.......260.......270.......280.......290.......300.....--..----310.--.--.....320.......330-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
N
Y
R
K
L
I
V
L
L
L
L
T
F
F
V
I
F
M
G
A
Y
A
Y
T
H
I
V
E
KRSL
T
S
N
T
I
E
K
T
L
P
V
V
N
QI
K
P
Q
T
I
K
E
Y
Q
N
Y
L
T
K
V
A
KRNVLPV-DI
P
Q
ALN-NE
K
V
E
I
T
ATDG
M
Q
T
F
T
WNDKNNP
K
Q
---
K
V
I
F
Y
VHGGS
Y
I
HQASEL
Q
Y
I
F
V
N
K
L
A
K
KLDA
K
V
V
F
P
I-YPKAPTYNYSDA
I
P
K
I
K
K
L
Y
Q
N
T
L
A
S-----V-----TSP
K
Q
I
I
L
V
GESAGG
G
L
A
L
G
L
A
D
N
L
V
T
E
H
IKQP
K
E
I
I
L
ISP
W
L
DIATNNPK
I
-
E
K
V-QKKDP
L
L
K
A
W
--
Q
--
L
QQVAPYWANGKKNFKNPQVS
P
L
Y
S
SQFNKMA
P
I
S
F
F
IGTHDIFYP
D
N
Q
L
L
H
Q
K
L
A
K
ENIKH
H
Y
I
VGQKMN
H
--
V
Y----PVLP--I--P
E
A
E
T
A
F
K
Q
M
L
K
I
INH---
29
HHSearch
91.96
25%
-80
- C1 -
3D7R
13
?
A:
[29-320]
------------------------------------
S
V
V
N
K
Y
L
L
H
N
R
S
I
M
F
K
N
D
Q
D
V
E
R
F
F
Y
K
R
E
I
E
N
R
K
K
H
K
Q
P
S
T
L
N
V
-
K
A
N
L
E
K
L
S
L
D
D
M
Q
V
F
R
F
N
F
R
H
-
Q
I
D
---
K
K
I
L
Y
I
H
G
G
F
N
A
L
Q
P
S
P
F
H
W
R
L
L
D
K
I
T
L
S
T
L
Y
E
V
V
L
P
I
-
Y
P
K
T
P
E
F
H
I
D
D
T
F
Q
A
I
Q
R
V
Y
D
Q
L
V
S
E
-----
V
-----
G
-
H
Q
N
V
V
V
M
G
D
G
S
G
G
A
L
A
L
S
F
V
Q
S
L
L
D
N
Q
Q
P
L
P
N
K
L
Y
L
I
S
P
I
L
D
A
T
L
S
N
K
D
I
-
S
D
A
L
I
E
Q
D
A
V
L
S
Q
F
--
G
--
V
N
E
I
M
K
K
W
A
N
-
G
L
P
L
T
D
K
R
I
S
P
I
N
G
-
T
I
E
G
L
P
P
V
Y
M
F
G
G
G
R
E
M
T
H
P
D
M
K
L
F
E
Q
M
M
L
Q
H
H
Q
Y
I
E
F
Y
D
Y
P
K
M
V
H
--
D
F
----
P
I
Y
P
--
I
--
R
Q
S
H
K
A
I
K
Q
I
A
K
S
I
D
E
---
1
PsiBlast_PDB
90.47
27%
-88
- C1 -
3D7R
11
?
A:
[67-319]
---------------------------------------------------------------------------
P
S
T
L
N
V
K
A
N
L
E
K
L
S
L
D
D
M
Q
V
F
R
F
N
F
R
H
Q
I
D
K
---
K
I
L
-
Y
I
H
G
G
F
N
A
L
Q
P
S
P
F
H
W
R
L
L
D
K
I
T
L
S
T
L
Y
E
V
V
L
P
I
-
Y
P
K
T
P
E
F
H
I
D
D
T
F
Q
A
I
Q
R
V
Y
-
D
Q
L
V
S
-----
E
-----
V
G
H
Q
N
V
V
V
M
G
D
G
S
G
G
A
L
A
L
S
F
V
Q
S
L
L
D
N
Q
Q
P
L
P
N
K
L
Y
L
I
S
P
I
L
D
A
T
L
S
N
K
D
I
S
D
A
L
-
I
E
Q
D
A
V
L
S
Q
F
--
G
--
V
N
E
I
M
K
K
W
A
N
G
L
P
-
L
T
D
K
R
I
S
P
I
-
N
G
T
I
E
G
L
P
P
V
Y
M
F
G
G
G
R
E
M
T
H
P
D
M
K
L
F
E
Q
M
M
L
Q
H
H
Q
Y
I
E
F
Y
D
Y
P
K
M
V
H
--
D
F
----
P
I
Y
P
--
I
--
R
Q
S
H
K
A
I
K
Q
I
A
K
S
I
D
E
---
23
Fugue
83.46
22%
-78
- C1 -
4Q3O
8
?
A:
[31-347]
----
E
V
P
I
P
Q
S
I
S
A
E
F
K
A
A
L
A
Q
Y
P
T
P
S
V
E
E
A
R
S
F
V
---------------
P
T
T
A
A
Q
W
R
D
Y
V
Q
A
T
N
K
M
Q
K
T
K
I
-
K
N
M
R
K
H
Y
-
G
V
T
V
E
L
L
D
I
K
G
V
T
V
R
K
I
T
P
K
S
L
S
P
E
FKD
H
V
Y
I
D
I
H
G
G
A
Y
V
L
F
A
G
L
P
S
I
E
E
G
I
L
I
A
H
R
L
G
I
V
V
Y
S
V
D
-
Y
R
M
P
P
A
Y
P
F
P
A
A
L
D
D
V
K
H
V
Y
R
-
V
L
S
Q
-----
Q
-----
Y
D
A
N
H
I
F
M
G
G
T
S
A
G
G
G
L
L
L
A
F
V
Q
G
L
I
E
N
G
V
A
T
P
R
A
I
Y
A
G
T
P
W
A
D
L
T
K
T
G
D
S
L
-
Y
T
N
-
E
G
I
D
R
I
L
I
T
Y
DG
T
--
L
G
A
S
A
R
L
Y
A
-
G
N
T
P
L
T
H
P
K
L
S
P
I
Y
G
D
-
F
T
D
F
P
P
T
F
L
V
T
G
T
R
D
M
F
L
S
D
T
V
R
V
N
R
K
M
R
D
A
G
V
T
T
V
L
D
V
Y
E
G
L
S
H
--
A
D
----
Y
L
V
S
--
H
QT
P
E
S
Q
S
V
Y
R
Q
L
K
R
F
L
V
G
F
T-
30
HHSearch
79.09
22%
-74
- C1 -
3FAK
1
?
A:
[56-306]
---------------------------------------------------------------------------------
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
---
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G----
F
-----
K
-
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
V
A
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
-
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
-
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
----
H
A
F
H
PM
L
--
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
---
25
Fugue
77.04
20%
-64
- C1 -
4Q05
2
?
A:
[34-360]
E
N
S
W
Q
-------
I
G
P
R
T
L
P
A
P
S
G
A
S
D
V
L
Y
N
I
I
S
K
T
P
T
P
V
P
---
T
I
N
L
N
L
V
P
R
T
E
S
E
W
R
A
A
I
T
Q
L
D
E
G
K
V
D
M
A
-
R
E
I
S
K
Q
L
-
S
V
S
V
E
H
G
V
I
E
G
V
S
V
Y
Y
V
T
P
V
E
V
A
P
D
LED
K
L
F
V
H
T
H
G
G
A
F
V
L
N
G
G
E
A
G
T
I
E
A
I
V
I
A
T
L
A
K
V
R
V
L
S
I
D
-
Y
R
M
P
P
S
H
P
A
P
A
A
R
D
D
V
F
T
V
Y
Q
H
L
L
K
Q
-----
G
-----
S
A
Q
K
-
I
A
L
G
G
S
S
G
G
A
N
L
T
M
G
L
V
Q
H
L
I
E
Q
E
V
D
L
P
G
A
L
F
L
G
T
P
G
A
D
M
S
K
T
G
D
S
Y
-
Y
I
N
-
D
G
I
D
R
N
L
V
T
Y
--
D
G
F
L
E
A
A
V
R
L
Y
A
N
G
R
-
D
L
K
D
P
L
V
S
P
L
Y
G
D
-
L
H
G
F
P
P
T
F
L
I
T
G
T
R
D
L
L
L
S
A
T
V
R
T
H
I
K
L
R
Q
S
G
V
V
A
D
L
F
V
Y
E
G
I
A
H
GD
Y
A
----
V
D
L
T
--
A
--
P
E
T
Q
H
A
F
A
E
L
N
A
F
L
L
Q
HLR
18
PsiBlast_PDB
76.68
24%
-94
- C1 -
4Q3O
8
?
A:
[117-343]
--------------------------------------------------------------------------------------------------------
K
D
---
H
V
Y
I
D
I
H
G
G
A
Y
V
L
F
A
G
-
L
P
S
I
E
E
G
I
L
I
A
H
R
L
G
I
V
V
Y
S
V
D
Y
R
M
P
P
A
Y
P
F
P
A
A
L
D
D
V
K
H
V
Y
R
-
V
L
S
Q
-----
Q
-----
Y
D
A
N
H
I
F
M
G
G
T
S
A
G
G
G
L
L
L
A
F
V
Q
G
L
I
E
N
G
V
A
T
P
R
A
I
Y
A
G
T
P
W
A
D
L
T
K
T
G
D
S
L
-
Y
T
N
-
E
G
I
D
R
I
L
I
T
Y
--
D
G
T
L
G
A
S
A
R
L
Y
A
-
G
N
T
P
L
T
H
P
K
L
S
P
I
Y
-
G
D
F
T
D
F
P
P
T
F
L
V
T
G
T
R
D
M
F
L
S
D
T
V
R
V
N
R
K
M
R
D
A
G
V
T
T
V
L
D
V
Y
E
G
L
S
H
--
A
D
----
Y
L
V
S
HQ
T
--
P
E
S
Q
S
V
Y
R
Q
L
K
R
F
L
V
G
---
31
HHSearch
74.11
20%
-82
- C1 -
3K6K
3
?
A:
[59-306]
-----------------------------------------------------------------------------------
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
G
A
---
A
H
I
L
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
-
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
-----
A
G----
S
-
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
-
S
N
L
-
A
D
R
D
F
L
A
E
P
D
--
T
--
L
G
E
M
S
E
L
Y
V
G
-
G
E
D
R
K
N
P
L
I
S
P
V
Y
A
-
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
--
V
F
----
Q
M
Y
G
--
K
FV
N
A
A
D
I
S
I
K
E
I
C
H
W
I
S
A
---
12
PsiBlast_PDB
71.84
24%
-85
- C1 -
3L1H
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
---
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
11
PsiBlast_PDB
71.38
24%
-85
- C1 -
3H1B
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
V
A
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
13
PsiBlast_PDB
71.20
24%
-81
- C1 -
3L1I
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
---
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
35
HHSearch
71.03
16%
-84
- C1 -
3QH4
-
?
A:
[68-309]
-------------------------------------------------------------------------------------------
P
V
P
V
R
I
Y
R
A
A
P
-
T
P
A
---
P
V
V
V
Y
C
H
A
G
G
F
A
L
G
N
L
D
T
D
H
R
Q
C
L
E
L
A
R
R
A
R
C
A
V
V
S
V
D
-
Y
R
L
A
P
E
H
P
Y
P
A
A
L
H
D
A
I
E
V
L
T
W
V
V
G
N
ATRLG
F
-----
D
-
A
R
R
L
A
V
A
G
S
S
A
G
A
T
L
A
A
G
L
A
H
G
A
A
D
G
S
L
P
P
V
I
F
Q
L
L
H
Q
P
V
L
D
D
R
P
T
A
S
-
R
-
S
E
F
-
R
-
A
T
P
A
F
D
G
E
--
A
--
A
S
L
M
W
R
H
Y
L
A
-
G
Q
-
T
P
S
P
E
S
V
P
G
R
R
G
Q
L
A
G
L
P
A
T
L
I
T
C
G
E
I
D
P
F
R
D
E
V
L
D
Y
A
Q
R
L
L
G
A
G
V
S
T
E
L
H
I
F
P
R
A
C
H
--
G
F
----
D
S
L
L
PE
W
--
T
T
S
Q
R
L
F
A
M
Q
G
H
A
L
A
D
---
14
PsiBlast_PDB
70.75
24%
-81
- C1 -
3L1J
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
---
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
3
PsiBlast_PDB
70.68
24%
-82
- C1 -
3FAK
1
?
A:
[81-291]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
V
A
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
10
PsiBlast_PDB
70.44
24%
-82
- C1 -
3H1A
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
V
A
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
9
PsiBlast_PDB
70.30
24%
-84
- C1 -
3H19
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
---
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
6
PsiBlast_PDB
70.19
24%
-80
- C1 -
3G9Z
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
V
A
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
2
PsiBlast_PDB
69.98
24%
-82
- C1 -
3V9A
3
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
---
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
4
PsiBlast_PDB
69.84
24%
-81
- C1 -
3G9T
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
--
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---
33
HHSearch
69.27
17%
-80
- C1 -
1JJI
1
?
A:
[67-309]
-------------------------------------------------------------------------------------------
D
I
R
V
R
V
Y
Q
Q
K
P
--
D
S
---
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
S
H
D
A
L
C
R
R
I
A
R
L
S
N
S
T
V
V
S
V
D
-
Y
R
L
A
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
-----
A
EELRI
D
-
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
S
L
-
L
E
F
-
G
E
G
L
W
I
L
D
Q
K
--
I
--
M
S
W
F
S
E
Q
Y
F
S
R
E
E
D
K
F
N
P
L
A
S
V
I
F
A
-
D
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
--
G
F
----
I
N
Y
Y
--
P
VL
K
A
A
R
D
A
I
N
Q
I
A
A
L
L
V
F
---
5
PsiBlast_PDB
69.10
24%
-83
- C1 -
3G9U
-
?
A:
[68-278]
-------------------------------------------------------------------------------------------------------------
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
-
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
-----
G
-----
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
-
K
T
R
-
A
E
A
D
P
M
--
P
G
--
G
--
I
N
K
M
A
A
R
Y
L
N
G
-
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
-
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
--
V
W
HAFH
P
M
L
P
--
E
--
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
---