@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0817: (2015-12-03 )
MNTNDFDFYLPEELIAQTPLEKRDASKLLVIDHKNKTMTDSHFDHILDELKPGDALVMNNTRVLPARLYGEKPDTHGHIELLLLKNTEGDQWEVLAKPAKRLRVGTKVSFGDGRLIATVTKELEHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLEDRDRYQTVYAKENGSAAAPTAGLHFTKELLEKIETKGVKLVYLTLHVGLGTFRPVSVDNLDEHEMHSEFYQLSKEAADTLNAVKESGGRIVAVGTTSIRTLETIGSKFNGELKADSGWTNIFIKPGYQFKVVDAFSTNFHLPKSTLVMLVSAFAGRDFVLEAYNHAVEERYRFFSFGDAMFVK
Atome Classification :
(20 SA)
-------------------------.........10.--...---.....--20.-.....----..30.---....-...40---........50.-.......60.......---------------.70.--.......80........90........100----.......-.110.-------.-------.....120......--.130.--------------------------.--.....140....-..-.150.....-..160--.........-------170.---------------...-----...180..---.....190.......200..--------.....210..--.....220----------------------...---------------------..-------------..230..----------------.....240.......250-.-----......260.......--270...-----......--280--.--.....--------------------...290------.......------.300---.......-------310-.......----------.320.....------.-----.330.......340-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MNTNDF
D
F
YL-
P
--
E
E
L
---
I
A
QTP--LEK-RDA
S
K
----
L
L
V
I
D---HKNK-TM
T
D
S
---
H
F
D
H
I
L
D
ELKP-G
D
A
L
V
MNN
T
R
V
L
P
A
R
L---------------YGEK--PDTHG
H
I
E
L
L
L
L
KNTEGD
Q
W
E
V
L
AK
P
A
K
R-----LRVG
T
K
V
-SFGD
G
-------
R
-------
L
I
A
T
V
T
K
E
L
EHGG
R
--
I
V
E
F
S--------------------------Y--D
G
I
F
L
E
V
L
E
S
LG-EM-PL
P
P
Y
I
H
E
K
-LED----RDR
Y
Q
T
V
Y
A
-------KENG---------------SAA-----APTA
G
L
H
F
---
T
K
E
L
L
E
K
I
ETKG
V
K
L
V
Y
L
T
L
--------
H
VGLGTFRPV--SVDNL
D
E
H
----------------------
E
M
H
---------------------
S
E
-------------
F
Y
Q
L
S
K
E
----------------
A
A
D
T
L
N
A
V
K
ESG
G
R
I
V
A
V
-G-----TT
S
I
R
T
L
E
T
I
G
S
KFN
G
--
E
--
L
KA-----DSGW
T
N
--
I
----
F
--IKPG
Y
--------------------
Q
F
K
V
V
-------
D
AFSTNF------HL
P
K
---
S
T
L
V
M
L
V
-------
S
A
--FAGR
D
F
V
----------
L
E
A
Y
N
H
A
V
E
------
E
-----
R
Y
R
FFSFG
D
A
M
FVK-------
1
PsiBlast_PDB
98.24
67%
-115
- C4 -
1YY3
-
QUEA_BACSU
A:
[6-341]
------------------------------
F
D
F
E
L
-
P
--
E
R
L
---
I
A
Q
V
P
--
L
E
Q
-
R
D
A
S
R
----
L
M
V
L
D
---
K
H
T
G
-
E
L
T
D
S
---
S
F
K
H
I
I
S
F
F
N
E
-
G
D
C
L
V
L
N
N
T
R
V
L
P
A
R
L
---------------
F
G
T
K
--
E
D
T
G
A
K
V
E
L
L
L
L
K
Q
E
T
G
D
K
W
E
T
L
A
K
P
A
K
R
-----
V
K
K
G
T
V
V
-
T
F
G
D
G
-------
R
-------
L
K
A
I
C
T
E
E
L
E
H
G
G
R
--
K
M
E
F
Q
--------------------------
Y
--
D
G
I
F
Y
E
V
L
E
S
L
G
-
E
M
-
P
L
P
P
Y
I
K
E
Q
-
L
D
D
----
K
E
----------------------------------
A
A
-----
A
P
T
A
G
L
H
F
---
T
E
E
I
L
Q
Q
L
K
D
K
G
V
Q
I
E
F
I
T
L
--------
H
V
G
L
G
T
F
R
-----------------------------------
M
H
---------------------
A
E
-------------
F
Y
Q
M
S
E
E
----------------
T
A
A
A
L
N
K
V
R
E
N
G
G
R
I
I
S
V
-
G
-----
T
T
S
T
R
T
L
E
T
I
A
G
E
H
D
G
--
Q
--
F
K
A
-----
S
S
G
W
T
S
--
I
----
F
--
I
Y
P
G
Y
--------------------
E
F
K
A
I
-------
D
G
M
I
T
N
F
------
H
L
P
K
---
S
S
L
I
M
L
V
-------
S
A
--
L
A
G
R
E
N
I
----------
L
R
A
Y
N
H
A
V
E
------
E
-----
E
Y
R
F
F
S
F
G
D
A
M
L
I
--------
9
HHSearch
98.13
66%
-114
- C4 -
1YY3
-
QUEA_BACSU
A:
[4-341]
----------------------------
D
L
F
D
F
E
L
-
P
--
E
R
L
---
I
A
Q
V
P
--
L
E
Q
-
R
D
A
S
R
----
L
M
V
L
D
---
K
H
T
G
-
E
L
T
D
S
---
S
F
K
H
I
I
S
F
F
N
E
-
G
D
C
L
V
L
N
N
T
R
V
L
P
A
R
L
---------------
F
G
T
K
--
E
D
T
G
A
K
V
E
L
L
L
L
K
Q
E
T
G
D
K
W
E
T
L
A
K
P
A
K
R
-----
V
K
K
G
T
V
V
-
T
F
G
D
G
-------
R
-------
L
K
A
I
C
T
E
E
L
E
H
G
G
R
--
K
M
E
F
Q
--------------------------
Y
--
D
G
I
F
Y
E
V
L
E
S
L
G
-
E
M
-
P
L
P
P
Y
I
K
E
Q
-
L
D
D
----
K
E
----------------------------------
A
A
-----
A
P
T
A
G
L
H
F
---
T
E
E
I
L
Q
Q
L
K
D
K
G
V
Q
I
E
F
I
T
L
--------
H
V
G
L
G
T
F
R
-----------------------------------
M
H
---------------------
A
E
-------------
F
Y
Q
M
S
E
E
----------------
T
A
A
A
L
N
K
V
R
E
N
G
G
R
I
I
S
V
-
G
-----
T
T
S
T
R
T
L
E
T
I
A
G
E
H
D
G
--
Q
--
F
K
A
-----
S
S
G
W
T
S
--
I
----
F
--
I
Y
P
G
Y
--------------------
E
F
K
A
I
-------
D
G
M
I
T
N
F
------
H
L
P
K
---
S
S
L
I
M
L
V
-------
S
A
--
L
A
G
R
E
N
I
----------
L
R
A
Y
N
H
A
V
E
------
E
-----
E
Y
R
F
F
S
F
G
D
A
M
L
I
--------
8
PsiBlast_CBE
90.98
50%
-117
- C4 -
1VKY
1
QUEA_THEMA
B:
[16-346]
----------------------------
S
E
F
D
Y
E
L
-
P
--
P
E
L
---
I
A
Q
E
P
--
V
E
P
-
R
D
A
S
R
----
L
M
V
L
H
---
R
K
T
Q
-
R
I
E
H
R
---
I
F
R
E
I
I
E
Y
L
E
P
-
G
D
L
L
V
L
N
V
S
K
V
I
P
A
R
L
---------------
Y
A
R
K
-----
G
A
S
I
E
I
L
L
I
E
R
L
E
E
G
I
W
K
C
L
V
R
P
G
Q
K
-----
V
K
K
G
T
E
L
-
V
I
-
D
E
-------
D
-------
L
S
A
V
C
L
G
R
G
E
D
G
T
R
--
I
L
K
F
Q
--------------------------
P
QD
D
R
L
I
F
E
K
----
G
------------------------------------------------------------------
T
A
G
L
H
F
---
T
P
E
L
I
E
K
L
K
K
K
G
V
Q
F
A
E
V
V
L
--------
H
V
G
I
----------------------------------------
H
---------------------
E
E
-------------
F
Y
Q
V
P
K
E
----------------
T
V
R
K
L
R
E
T
R
E
R
G
N
R
I
V
A
V
-
G
-----
T
T
T
V
R
T
L
E
T
I
A
R
--
L
P
--
E
--
Q
E
E
-----
Y
V
G
K
T
D
--
L
----
F
--
I
Y
P
P
F
--------------------
E
F
K
L
V
-------
D
A
L
V
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
A
G
K
D
F
V
----------
M
E
A
Y
R
E
A
V
K
------
R
-----
R
Y
R
F
F
S
F
G
D
A
M
L
I
L
-------
10
HHSearch
90.04
51%
-118
- C4 -
1VKY
1
QUEA_THEMA
A:
[16-347]
----------------------------
S
E
F
D
Y
E
L
-
P
--
P
E
L
---
I
A
Q
E
P
--
V
E
P
-
R
D
A
S
R
----
L
M
V
L
H
---
R
K
T
Q
-
R
I
E
H
R
---
I
F
R
E
I
I
E
Y
L
E
P
-
G
D
L
L
V
L
N
V
S
K
V
I
P
A
R
L
---------------
Y
A
R
K
------
A
S
I
E
I
L
L
I
E
R
L
E
E
G
I
W
K
C
L
V
R
P
G
Q
K
-----
V
K
K
G
T
E
L
-
V
I
D
E
--------
D
-------
L
S
A
V
C
L
G
R
G
E
D
G
T
R
--
I
L
K
F
Q
--------------------------
P
----
Q
D
D
R
L
I
F
E
K
G
------------------------------------------------------------------
T
A
G
L
H
F
---
T
P
E
L
I
E
K
L
K
K
K
G
V
Q
F
A
E
V
V
L
--------
H
V
------------------------------------------
H
---------------------
E
E
-------------
F
Y
Q
V
P
K
E
----------------
T
V
R
K
L
R
E
T
R
E
R
G
N
R
I
V
A
V
-
G
-----
T
T
T
V
R
T
L
E
T
I
A
R
L
--
P
--
E
--
Q
E
E
-----
Y
V
G
K
T
D
--
L
----
F
--
I
Y
P
P
F
--------------------
E
F
K
L
V
-------
D
A
L
V
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
A
G
K
D
F
V
----------
M
E
A
Y
R
E
A
V
K
------
R
-----
R
Y
R
F
F
S
F
G
D
A
M
L
I
L
-------
2
PsiBlast_PDB
89.76
50%
-119
- C4 -
1VKY
1
QUEA_THEMA
A:
[16-346]
----------------------------
S
E
F
D
Y
E
L
-
P
--
P
E
L
---
I
A
Q
E
P
--
V
E
P
-
R
D
A
S
R
----
L
M
V
L
H
---
R
K
T
Q
-
R
I
E
H
R
---
I
F
R
E
I
I
E
Y
L
E
P
-
G
D
L
L
V
L
N
V
S
K
V
I
P
A
R
L
---------------
Y
A
R
K
------
A
S
I
E
I
L
L
I
E
R
L
E
E
G
I
W
K
C
L
V
R
P
G
Q
K
-----
V
K
K
G
T
E
L
-
V
I
-
D
E
-------
D
-------
L
S
A
V
C
L
G
R
G
E
D
G
T
R
--
I
L
K
F
Q
--------------------------
P
QD
D
R
L
I
F
E
K
----
G
------------------------------------------------------------------
T
A
G
L
H
F
---
T
P
E
L
I
E
K
L
K
K
K
G
V
Q
F
A
E
V
V
L
--------
H
V
------------------------------------------
H
---------------------
E
E
-------------
F
Y
Q
V
P
K
E
----------------
T
V
R
K
L
R
E
T
R
E
R
G
N
R
I
V
A
V
-
G
-----
T
T
T
V
R
T
L
E
T
I
A
R
--
L
P
--
E
--
Q
E
E
-----
Y
V
G
K
T
D
--
L
----
F
--
I
Y
P
P
F
--------------------
E
F
K
L
V
-------
D
A
L
V
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
A
G
K
D
F
V
----------
M
E
A
Y
R
E
A
V
K
------
R
-----
R
Y
R
F
F
S
F
G
D
A
M
L
I
L
-------
23
Fugue
88.80
49%
-111
* C4 *
1VKY
1
QUEA_THEMA
A:
[16-347]
----------------------------
S
E
F
D
Y
E
L
-
P
--
P
E
L
---
I
A
Q
E
P
--
V
E
P
-
R
D
A
S
R
----
L
M
V
L
H
---
R
K
T
Q
-
R
I
E
H
R
---
I
F
R
E
I
I
E
Y
L
E
P
-
G
D
L
L
V
L
N
V
S
K
V
I
P
A
R
L
---------------
Y
A
R
K
------
A
S
I
E
I
L
L
I
E
R
L
E
E
G
I
W
K
C
L
V
R
P
G
Q
K
-----
V
K
K
G
T
E
L
-
V
I
D
E
D
---------------
L
S
A
V
C
L
G
R
G
E
D
G
T
R
--
I
L
K
F
Q
--------------------------------------------------------------
P
Q
D
D
R
L
I
F
E
-------
K
---------------------------
G
T
A
G
L
H
F
---
T
P
E
L
I
E
K
L
K
K
K
G
V
Q
F
A
E
V
V
L
--------
H
V
------------------------------------------
H
---------------------
E
E
-------------
F
Y
Q
V
P
K
E
----------------
T
V
R
K
L
R
E
T
R
E
R
G
N
R
I
V
A
V
-
G
-----
T
T
T
V
R
T
L
E
T
I
A
R
--
L
P
--
E
--
Q
E
E
-----
Y
V
G
K
T
D
--
L
----
F
--
I
Y
P
P
F
--------------------
E
F
K
L
V
-------
D
A
L
V
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
A
G
K
D
F
V
----------
M
E
A
Y
R
E
A
V
K
------
R
-----
R
Y
R
F
F
S
F
G
D
A
M
L
I
L
-------
11
HHSearch
84.26
47%
-103
- C4 -
1WDI
1
QUEA_THET2
A:
[3-345]
--------------------------
G
L
E
A
Y
D
Y
H
L
-
P
--
P
E
Q
---
I
A
Q
E
G
--
V
E
P
-
R
D
M
A
R
----
L
M
V
V
Y
---
R
E
G
P
F
R
V
A
H
K
---
R
V
R
D
L
P
E
F
L
R
P
-
G
D
V
L
V
F
N
E
S
K
V
I
P
A
R
L
---------------
L
A
R
K
--
P
-
T
G
G
K
V
E
I
L
L
V
R
E
R
------
A
L
L
G
P
A
R
K
-----
A
P
P
G
T
R
L
-
L
L
L
S
P
KDLAPVP
G
-------
L
Q
A
E
V
V
A
V
E
E
D
------------------------------------------
L
V
A
H
L
E
E
V
G
-
E
V
-
P
-----------------------------------------------------
A
-----
A
P
T
A
G
L
H
F
---
T
P
E
L
L
E
R
L
R
E
M
G
V
E
L
R
F
L
T
L
--------
H
V
G
P
G
T
F
R
P
----------------------------------
M
H
---------------------
A
E
-------------
P
Y
A
I
P
E
E
----------------
V
A
E
A
V
N
R
A
K
A
E
G
R
R
V
V
A
V
-
G
-----
T
T
V
V
R
A
L
E
S
A
Y
R
E
-
G
V
--
G
--
V
V
A
-----
G
E
G
E
T
R
--
L
----
F
--
I
R
P
P
Y
--------------------
T
F
K
V
V
-------
D
A
L
F
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
L
G
R
E
R
T
----------
L
E
A
Y
R
L
A
V
A
------
E
-----
G
Y
R
F
Y
S
L
G
D
A
M
L
I
L
-------
3
PsiBlast_PDB
83.68
47%
-109
- C4 -
1WDI
1
QUEA_THET2
A:
[7-344]
------------------------------
Y
D
Y
H
L
-
P
--
P
E
Q
---
I
A
Q
E
G
--
V
E
P
-
R
D
M
A
R
----
L
M
V
V
Y
---
R
E
G
P
F
R
V
A
H
K
---
R
V
R
D
L
P
E
F
L
R
P
-
G
D
V
L
V
F
N
E
S
K
V
I
P
A
R
L
---------------
L
A
R
K
--
P
-
T
G
G
K
V
E
I
L
L
V
R
E
R
------
A
L
L
G
P
A
R
K
-----
A
P
P
G
T
R
L
-
L
L
L
S
P
-------
K
DLAPVPG
L
Q
A
E
V
V
A
V
E
E
D
------------------------------------------
L
V
A
H
L
E
E
V
G
-
E
V
-
P
-----------------------------------------------------
A
-----
A
P
T
A
G
L
H
F
---
T
P
E
L
L
E
R
L
R
E
M
G
V
E
L
R
F
L
T
L
--------
H
V
G
P
G
T
F
R
P
----------------------------------
M
H
---------------------
A
E
-------------
P
Y
A
I
P
E
E
----------------
V
A
E
A
V
N
R
A
K
A
E
G
R
R
V
V
A
V
-
G
-----
T
T
V
V
R
A
L
E
S
A
Y
R
E
G
V
G
-----
V
V
A
-----
G
E
G
E
T
R
--
L
----
F
--
I
R
P
P
Y
--------------------
T
F
K
V
V
-------
D
A
L
F
T
N
F
------
H
L
P
R
---
S
T
L
L
M
L
V
-------
A
A
--
F
L
G
R
E
R
T
----------
L
E
A
Y
R
L
A
V
A
------
E
-----
G
Y
R
F
Y
S
L
G
D
A
M
L
I
L
-------
29
Fugue
40.80
11%
-24
- C4 -
1F3T
4
DCOR_TRYBB
A:
[14-422]
-------------------------------
R
F
L
E
G---
F
N
T
---
R
D
A
L
C
--
K
K
I
-
S
-
G
D
P
----
F
F
V
A
D
---
L
G
D
I
-
V
R
K
H
E
---
T
W
K
K
C
L
P
R
V
T
P
-
F
Y
A
V
K
C
N
D
D
W
R
V
L
G
T
L
---------------
A
A
L
G
T
G
F
D
C
A
S
N
T
E
I
Q
R
V
R
G
I
G
V
P
P
E
K
I
I
Y
A
N
P
C
K
-----
Q
I
S
H
I
R
Y
-
A
R
D
S
G
-------
V
-------
D
V
M
T
F
D
-
C
V
D
E
L
E
K
--
V
A
K
T
H
--------------------------
P
--
K
A
K
M
V
L
R
I
S
T
V
K
-
F
G
-
A
K
V
E
D
C
R
F
I
-
L
E
Q
----
A
K
K
L
N
I
D
V
T
G
V
S
F
H
VG
S
G
S
T
---------------
D
A
S
-----
T
F
A
Q
A
I
S
D
---
S
R
F
V
F
D
M
G
T
E
L
G
F
N
M
H
I
L
D
I
--------
G
G
G
F
P
G
T
R
D
A
--
P
L
K
F
E
E
I
A
----------------------
G
V
I
---------------------
N
N
-------------
A
L
E
K
H
F
P
----------------
P
D
L
K
L
T
I
V
A
E
P
G
R
Y
Y
V
A
S
-
A
-----
F
T
L
A
V
N
V
I
A
K
K
V
T
--
Q
S
F
M
--
Y
Y
V
-----
N
D
G
V
Y
G
--
S
----
F
--
N
C
I
L
Y
DH
A
V
V
R
P
L
P
QREPIPNEKL
Y
P
S
S
V
W
G
PTCDGL
D
Q
I
V
E
R
Y
------
Y
L
P
E
MQV
G
E
W
L
L
F
E
-------
D
M
--
G
A
Y
T
V
V
G
----------
T
S
S
F
N
G
F
Q
S
------
P
-----
T
I
Y
Y
V
V
S
G
L
P
D
H
V
V
R
E
L
K
S--
26
Fugue
36.56
13%
13
- C4 -
4D9I
1
DPAL_ECOLI
A:
[2-397]
------------------------S
V
F
S
L
K
I
D
I
A
D
-
N
--
K
F
F
---
N
G
E
T
S
PL
F
S
Q
-
S
Q
A
K
L
----
A
R
Q
F
H
---
Q
K
I
A
-
G
Y
R
P
T
PLC
A
L
D
D
L
A
N
L
F
G
V
-
K
K
I
L
V
K
D
E
S
K
R
F
G
L
N
A
---------------
F
I
T
M
--
L
G
G
A
Y
A
I
A
Q
L
L
C
E
K
Y
H
L
D
I
E
T
L
S
F
E
H
L
K
N
A
I
G
E
K
M
T
F
A
T
T
T
-
D
G
N
H
G
-------
R
-------
G
V
A
W
A
A
Q
Q
L
--
G
Q
N
--
A
V
I
Y
M
--------------------------
P
--
K
G
S
A
Q
E
R
V
D
A
I
L
-
N
L
-
G
A
E
C
I
V
T
D
M
N
Y
D
D
----
T
V
R
L
T
M
Q
H
A
-------
Q
Q
H
G
W
E
V
VQDTAWEG
Y
T
K
I
P
T
W
-----
I
M
Q
G
Y
A
T
L
---
A
D
E
A
V
E
Q
M
R
E
M
G
V
T
P
T
H
V
L
L
--------
Q
A
G
V
G
A
M
A
G
G
--
V
L
G
Y
L
V
D
V
----------------------
Y
S
P
---------------------
Q
N
L
H
S
I
I
V
EPDK
A
D
C
I
Y
R
S
G
V
K
G
D
I
VNVIMAGLACGE
P
N
P
L
G
W
E
I
L
R
N
C
A
T
Q
F
I
S
C
Q
D
-----
S
V
A
A
L
G
M
R
V
L
G
N
P
Y
G
N
--
D
--
P
R
I
-----
I
S
G
E
S
G
--
A
V
G
L
G
V
--
L
A
A
V
H
--------------------
Y
H
P
Q
R
-------
Q
S
L
M
E
K
L
------
A
L
N
K
---
D
A
V
V
L
V
I
-------
S
T
--
E
G
D
T
D
--------------------
V
------
K
-----
H
Y
R
E
V
V
W
E
G
K
H
A
V
A
-------
24
Fugue
35.94
11%
-31
- C4 -
2YJG
4
?
A:
[2-426]
AN
I
E
I
P
Y
GK
S
K
L
A
F
D
L
P
DERIQGIL
R
S
K
M
S
E
E
D
I
V
-
K
--
R
A
L
E
N
P
I
G
T
K
R
--
L
Q
D
-
L
A
E
G
K
K
N
I
V
I
I
T
S
D
---
H
T
R
P
-
V
P
S
R
I
---
T
L
P
L
L
L
D
E
I
R
K
-
K
N
----
K
S
A
N
V
K
I
L
I
A
---------------
T
G
F
H
--
R
G
T
T
L
Q
E
M
K
A
K
F
G
E
D
L
V
E
N
E
Q
F
V
V
H
D
S
R
N
-----
S
E
N
M
E
L
I
-
G
T
L
P
S
-------
G
-------
G
K
L
E
I
N
K
L
A
V
E
A
D
L
--
L
V
A
E
G
--------------------------
F
--
I
E
P
H
F
F
A
G
F
S
G
G
-
R
K
-
S
I
L
P
G
I
A
S
V
-
Q
C
I
----
L
A
N
H
C
S
E
F
I
-------
K
N
P
Y
---------------
A
R
T
-----
G
V
L
E
N
N
P
I
---
H
R
D
M
I
Y
A
A
K
K
A
N
L
A
F
I
L
N
V
V
I
D
SSHKIV
N
A
F
A
G
H
S
E
K
A
--
H
L
K
G
C
E
F
V
----------------------
S
E
I
A
T
V
N
A
KPAD
I
V
I
T
S
NGGYPLD
Q
N
-------------
I
Y
Q
S
V
K
G
----------------
M
T
A
G
E
A
A
C
K
D
G
G
V
I
I
I
A
A
-
E
-----
C
A
D
G
H
G
G
E
G
F
Y
R
W
F
K
E
--
S
--
K
D
P
-----
Q
D
V
M
N
K
--
I
----
L
S
R
G
R
D
E
T
--------------------
L
P
D
Q
W
-------
E
A
Q
I
L
A
R
------
I
L
I
N
---
H
K
V
I
M
V
T
-------
D
S
--
K
N
Y
E
Y
V
K
D
M
F
M
T
P
A
KD
L
G
E
A
L
K
I
A
E
S
------
I
VNND
S
K
I
N
V
I
P
D
G
V
S
V
I
V
R
E
K-----
31
Fugue
33.88
9%
-32
- C1 -
1U9T
-
?
A:
[1-337]
---------------------------
M
N
H
Y
T
R
W
L
-
E
--
L
K
E
---
Q
A
R
D
I
--
A
G
L
-
M
N
I
R
E
----
A
E
L
A
F
A
R
V
T
H
D
A
-
W
R
M
H
G
---
D
I
R
D
I
L
A
A
L
E
S
V
G
E
T
K
C
I
C
R
N
E
Y
A
V
H
E
Q
---------------
V
G
T
F
--
T
N
Q
H
L
N
G
H
A
G
L
I
L
N
P
R
A
L
D
L
R
L
F
L
N
Q
W
A
S
-----
V
F
H
I
K
E
N
-
T
A
R
G
E
-------
R
-------
Q
S
I
Q
F
F
D
H
Q
G
D
A
L
L
--
K
V
Y
A
T
--------------------------
D
--
N
T
D
M
A
A
W
S
E
L
L
A
-
R
F
-
I
T
D
E
--
N
T
P
-
L
E
L
----
K
V
V
Q
T
R
A
D
A
-------
T
V
V
E
---------------
Q
E
W
-----
R
A
M
T
D
V
H
Q
---
F
F
T
L
L
K
R
H
N
L
--------
T
R
--------
Q
Q
A
F
N
L
V
A
D
D
--
L
A
C
K
V
S
N
S
----------------------
A
L
A
---------------------
Q
I
-------------
L
E
S
A
Q
Q
D
----------------
G
N
E
I
M
V
F
V
G
N
R
G
C
V
Q
I
F
T
-
G
-------
V
V
E
K
V
V
P
M
K
G
W
L
N
I
--
F
-----------
N
P
T
F
T
--
L
----
H
--
L
L
E
E
-----------------------
S
I
A
-------
E
A
W
V
T
R
K
------
P
T
S
D
---
G
Y
V
T
S
L
E
-------
L
F
--
A
H
D
G
T
Q
I
----------
A
Q
L
Y
G
Q
R
T
E
------
G
-----
D
Q
E
Q
A
Q
W
R
K
Q
I
A
S
L
I
P-----
25
Fugue
33.13
12%
-29
- C4 -
1WKV
2
CYSO_AERPE
A:
[2-383]
--------------------------
A
L
A
D
I
S
G
Y
L
-
D
VL
D
S
V
---
R
G
F
S
Y
--
L
E
N
A
R
E
V
L
R
----
S
G
E
A
R
---
C
L
G
N
-
P
R
S
E
P
---
E
Y
V
K
A
L
Y
V
I
G
A
-
S
R
I
P
V
G
D
G
C
S
H
T
L
E
E
L
GVFDISVPGEMVFPS
P
L
D
F
--
F
E
R
G
K
P
T
P
L
V
R
S
R
L
Q
L
P
N
G
V
R
V
W
L
K
L
E
W
Y
-----
N
P
F
S
L
S
V
K
D
R
P
A
V
-------
E
-------
I
I
S
R
L
S
R
R
V
E
K
G
S
L
--
V
A
D
A
T
S
S
N
F
G
V
A
L
S
A
V
A
R
L
Y
G
Y
R
A
R
V
Y
L
P
GA
A
--
E
E
F
G
K
L
L
P
R
L
L
G
A
Q
V
-
I
V
D
P
E
A
P
S
T
-
V
H
L
----
L
P
R
V
M
K
D
S
K
-------
N
E
G
F
---------------
V
H
V
NQFYN
D
A
N
F
E
A
H
M
R
G
T
A
R
E
I
F
V
Q
S
R
R
G
G
L
A
L
R
G
V
A
G
--------
S
L
G
T
S
G
H
M
S
A
--
A
A
F
Y
L
Q
S
V
----------------------
D
P
S
---------------------
I
R
-------------
A
V
L
V
Q
P
A
----------------
Q
G
D
S
I
P
G
I
R
R
V
E
T
G
M
L
W
I
-
N
MLD
I
S
Y
T
L
A
E
V
T
L
E
E
A
M
E
A
V
V
--
E
--
V
A
R
-----
S
D
G
-
L
V
--
I
----
G
--
P
S
G
G
A
--------------------
A
V
K
A
L
-------
A
K
K
A
A
E
G
------
D
L
E
P
---
G
D
Y
V
V
V
V
-------
P
D
--
T
G
F
K
----------------
Y
L
S
L
V
Q
------
N
-----
A
L
E
------------------
20
HHSearch
31.05
13%
-30
- C4 -
2YJG
2
?
A:
[82-149]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
L
P
L
L
L
D
E
I
R
K
K
N
-
K
S
A
N
V
K
I
--------
L
I
A
T
G
F
H
R
G
T
--
T
L
Q
E
M
K
A
K
-----------------------
F
G
---------------------
E
D
-------------
L
V
---
E
N
-----------------
E
Q
F
V
V
H
D
S
R
N
S
E
N
M
E
L
I
-
G
-----
T
L
P
S
G
G
K
L
E
I
N
K
L
A
V
E
--
A
--
D
L
L
-----
V
A
E
G
F
I
--
E
----
P
--
H
F
F
A
G
--------------------
F
S
G
G
R
-------
K
S
I
L
P
G
I
------
A
S
V
Q
---
C
I
L
A
N
H
C
-------
S
E
--
F
I
K
N
P
Y
A
----------
R
T
G
V
L
E
N
N
P
------
I
-----
H
R
D
M
I
Y
A
A
K
K
A
N
L
A
-------
5
PsiBlast_PDB
27.43
27%
-6
- C2 -
4N9G
-
?
A:
[25-121]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
S
F
S
S
Y
-
Y
-----
W
T
W
I
R
Q
S
P
G
K
G
L
E
W
I
G
--
E
--
M
N
G
-----
N
S
G
Y
T
N
----------
Y
N
P
S
L
--------------------
Q
S
R
V
T
I
S
K
----
D
---
N
Q
F
------
S
L
K
L
---
T
S
L
T
A
A
D
-------
T
A
V
Y
Y
C
A
R
D
A
I
----------
V
M
V
F
---
T
D
------
M
-----
R
G
R
V
D
V
W
G
P
G
I
L
V
T
-------
6
PsiBlast_PDB
25.04
24%
-14
* C5 *
1NRK
2
YGFZ_ECOLI
A:
[138-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
---------------------
S
K
-------------
E
K
Q
V
V
K
E
----------------
G
A
T
T
L
L
W
F
E
H
P
A
E
R
F
L
I
V
--------
T
D
E
A
T
A
N
M
L
T
D
K
L
R
G
--
E
A
E
L
N
N
-----
S
Q
Q
W
L
A
--
L
----
N
--
I
E
A
G
----------------------
F
P
V
I
-------
D
A
A
N
S
G
Q
------
F
I
P
Q
---
A
T
N
L
Q
A
L
GGISFKK
G
C
--
Y
T
G
Q
E
M
V
----------
A
R
A
K
F
R
G
A
N
------
K
-----
R
A
L
W
L
L
A
G
S
A
S
R
L
P
-------
27
Fugue
24.97
13%
1
- C4 -
3V7I
-
?
A:
[0-389]
---------------------------
A
M
A
A
Y
L
C
A
-
P
--
A
V
I
---
H
G
E
H
S
--
V
E
T
-
R
E
I
V
E
----
E
V
R
G
R
---
H
P
H
A
-
P
W
-----------
A
P
R
I
D
G
-
I
A
A
S
T
G
I
E
S
R
G
W
M
L
P
L
---------------
E
A
A
V
--
A
P
G
G
G
G
-
D
L
G
A
A
R
E
A
L
E
Q
D
A
N
R
A
I
A
A
L
K
A
-----
V
P
A
S
Q
T
V
-
Q
E
R
T
A
-------
P
-------
A
W
E
A
V
Q
A
Y
G
E
R
A
A
R
G
A
L
Q
I
A
G
--------------------------
L
--
D
V
A
D
V
D
C
L
I
T
S
N
-
S
T
T
P
A
L
P
G
L
D
V
A
-
L
A
N
R
LPL
R
G
D
T
M
L
L
P
A
-------
T
Q
W
A
----------------
C
V
-----
A
G
T
R
S
L
A
L
---
A
A
D
L
V
A
A
--
D
P
D
R
V
V
L
V
V
I
S
--------
E
A
L
S
T
T
Y
Q
P
A
DD
T
L
E
S
L
I
V
R
L
L
F
A
D
T
A
V
A
A
V
V
T
GRPRPESV
L
R
L
D
---------------------
A
A
-------------
W
H
H
T
L
P
G
----------------
T
R
D
L
H
R
L
E
T
R
A
D
G
T
H
F
V
M
-
D
-----
R
R
G
P
R
A
V
Q
E
T
V
T
A
M
W
E
--
W
--
L
R
V
R
Y
E
DD
P
S
S
W
H
P
DV
L
----
L
--
A
H
P
G
---------------------
G
T
R
V
L
-------
E
Y
M
E
Q
T
M
PDEWPS
G
L
L
S
---
Y
S
R
D
S
Y
T
-------
S
G
--
N
R
G
G
A
A
V
----------
F
D
I
L
R
R
A
H
D
A
GQKTG
S
-----
R
A
V
L
Y
A
A
A
P
G
L
T
A
T
A
L
E
G
E
W
L
7
PsiBlast_PDB
24.53
24%
-19
- C5 -
1VLY
2
YGFZ_ECOLI
A:
[147-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
---------------------
S
K
-------------
E
K
Q
V
V
K
E
----------------
G
A
T
T
L
L
W
F
E
H
P
A
E
R
F
L
I
V
--------
T
D
E
A
T
A
N
M
L
T
D
K
L
R
G
--
E
A
E
L
N
N
-----
S
Q
Q
W
L
A
--
L
----
N
--
I
E
A
G
----------------------
F
P
V
I
-------
D
A
A
N
S
G
Q
------
F
I
P
Q
---
A
T
N
L
Q
A
L
GGISFKK
G
C
--
Y
T
G
Q
E
M
V
----------
A
R
A
K
F
R
G
A
N
------
K
-----
R
A
L
W
L
L
A
G
S
A
S
R
L
P
-------
4
PsiBlast_PDB
22.40
30%
36
- C3 -
2NV2
-
PDXT_BACSU
B:
[141-191]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
A
G
E
N
V
E
V
L
S
E
H
N
G
R
I
V
A
A
-----------
K
Q
G
Q
F
L
G
C
S
F
N
P
--
E
--
L
T
E
-----
D
H
R
V
T
Q
--
L
----
F
--
V
E
M
V
E
--------------------
E
Y
K
Q
K
--------------------------------------------------------------------------------------------------------
21
HHSearch
21.60
23%
-28
- C4 -
1XNE
-
?
A:
[33-92]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
-----
I
K
R
G
D
K
I
-
I
F
N
D
L
---------------
I
P
A
E
V
V
E
---------
V
K
K
Y
E
-------------------------------
T
F
R
Q
V
L
R
E
E
P
-
I
D
-
K
I
F
P
D
K
P
S
F
-
E
K
A
----
L
K
R
F
H
N
M
Y
P
-------
K
W
K
E
---------------
Y
R
Y
-----
G
V
L
A
I
K
F
R
---
V
L
G
R
D
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------