@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0842: (2015-12-03 )
MKKLIIGIFSLIIIAILAWQGFSFLKHKEIKLQQAVVEKEIRIAEKTVEVVKRQKTERVLFLEPKGYDKSLSADILKWNQKSFEHKKFYDNQYIILRPQLADSNFANVKKLSIYQILYQKEKGSMFQKSSRLLRTYLLDQNKKPFELDELLAHNISGFKAILENIAPGTQLKEHDSNKEFLKTGRVTDGLDVKDGKLIINDLKLPLDKLYNVIDESYLKSSDLDLVSNLKAKAPRVALTFDDGPNEKTTPKALEILKRYNAKATFFVMGQSAVGHTDILQRMHAEGHEIGNHTWDHPNLTKLPAEKIKEEIHKTNDLIMKATGQKPVYLRPPYGATNATVKTVTGLKEMLWSVDTEDWKNHNTQAMMTNIKKQLRPGGVILMHDIHQTSIDALPTIMDYLITQGYYFVTVGELYSTP
Atome Classification :
(20 SA)
.........10........20........30........40.-........50........60......-------..70........80........90........100.......110.......120.......130.......140.......150...---....160.......170.......180.......190.......-200........210..-----....-.220.......--230.--......240....------------------------...250.......260-.......270----..-----.-...-..280.......290.......300-----.......310.......320.-.--...-..330.....-..340-------..---...----------------------..350.........360------------..-------..---....----370-..-----..-.-..-.---.380.--..----.---.---.-.390-..-.....400.-......410.....------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
L
I
I
G
I
F
S
L
I
I
I
A
I
L
A
WQG
F
S
F
L
K
H
K
E
I
K
L
Q
Q
A
V
V
E
K
E
-
I
-
R
I
A
E
K
T
V
E
V
V
K
RQKT
E
R
V
L
F
LEPKGY-------DKSL
S
A
D
I
L
KWNQKSFEHKKFYDN
Q
Y
I
I
L
RPQLADSNFAN
V
K
K
L
S
I
Y
Q
I
L
Y
QKEKG
S
M
F
Q
K
S
S
R
L
L
R
T
Y
L
LDQNKKPF
E
L
D
E
L
L
A
HNI---
S
G
F
K
A
I
L
E
NIAPGTQLKEHDS
N
K
E
F
L
K
TGRVTDGLDVKDG
K
L
I
I
-
N
D
-LKL
P
L
D
K
L
Y
N
V
I
D
-----
E
S
Y
L-KSS
D
L
D
L
V
S
NL--KAKA--
P
R
V
A
L
T
FDDGPNE------------------------KT
T
P
K
A
L
E
I
L
K
R
YNAK-
A
T
F
F
V
M
GQS-----AV-----
G
-
H
T
D
-
I
L
Q
R
M
HAEGHEIGNHTWDHPNLTKL-----
P
A
E
K
I
K
E
E
I
H
KTN
D
L
I
M
KATG-Q--K
P
V
-
Y
L
RPPYGATN-
A
T
V
K
T
-------
V
T
---
G
L
K
----------------------
E
M
L
--
W
SVD
T
E
D
WKNH-------------
N
T
-------
Q
A
---
M
M
T
N
----
I
---
K
K
-----QL-R-PG-
G
---
V
I
L
M
H--DI----H---Q---T-
S
I
D
A
-
L
P
-
T
I
M
D
Y
L
ITQ-
G
Y
Y
F
V
T
V
G
E
L
YSTP------------
51
Fugue
92.92
32%
-55
- C4 -
2C1I
4
PGDA_STRR6
A:
[14-431]
---------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
-
D
-
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
-------
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
S
K
D
N
-
L
V
F
Y
Y
T
E
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
I
E
-----
E
T
E
K
T
S
L
G
K
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
---
K
A
K
E
Q
L
I
K
E
L
T
S
F
D
L
S
A
---------------
W
N
F
D
Y
K
D
S
Q
I
I
L
-
Y
E
-
I
A
L
P
V
S
A
F
F
D
V
I
Q
-----
S
S
Y
L
-
L
E
K
D
A
A
L
Y
Q
S
Y
--
F
D
K
K
H
Q
K
V
V
A
L
T
F
N
D
G
P
N
P
------------------------
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
-
A
T
F
F
V
L
G
K
N
-----
V
S
-----
G
-
N
E
D
-
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
-----
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
-
S
--
S
S
K
-
L
M
R
P
P
Y
G
A
I
T
-
D
D
I
R
N
-------
S
L
---
D
L
S
----------------------
F
I
M
--
W
D
V
D
S
L
D
W
K
S
K
-------------
N
E
-------
A
S
---
I
L
T
E
----
I
---
Q
H
-----
Q
V
-
A
-
N
G
-
S
---
I
V
L
M
H
--
D
I
----
H
---
S
---
P
-
T
V
N
A
-
L
P
-
R
V
I
E
Y
L
K
N
Q
-
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
LKAHELYYSRDE
31
HHSearch
87.35
29%
-66
- C4 -
2C1I
4
PGDA_STRR6
A:
[14-418]
----------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
-
Y
Y
P
L
Q
G
EKVI
S
S
V
R
E
L
I
N
Q
D
V
K
---
D
--
K
--
L
-
E
S
K
D
N
L
V
F
Y
Y
T
E
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
-----
I
E
E
T
E
K
T
S
L
G
K
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
------------------
D
L
S
A
W
N
F
D
Y
K
D
S
Q
I
I
L
Y--E
I
A
L
P
V
S
A
F
F
D
V
I
Q
-----
S
S
Y
L
-
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
--
K
V
V
A
L
T
F
N
D
G
P
N
P
------------------------
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
-
A
T
F
F
V
L
G
K
N
-----
V
S
-----
G
-
N
E
D
-
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
-----
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
-
S
--
S
S
K
-
L
M
R
P
P
Y
G
A
I
T
-
D
D
I
R
N
-------
S
L
---
D
L
S
----------------------
F
I
M
--
W
D
V
D
S
L
D
W
K
S
K
-------------
N
E
-------
A
S
---
I
L
T
E
----
I
---
Q
H
-----
Q
V
-
A
-
N
G
-
S
---
I
V
L
M
H
--
D
I
----
H
---
S
---
P
-
T
V
N
A
-
L
P
-
R
V
I
E
Y
L
K
N
Q
-
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
------------
37
HHSearch
75.43
35%
-75
- C4 -
2C71
1
?
A:
[5-191]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
A
L
T
F
D
D
G
P
D
N
------------------------
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
-
A
T
F
M
V
V
G
Q
R
-----
V
N
-----
D
S
T
A
A
-
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
-----
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
-
T
--
T
P
K
-
F
F
R
P
P
N
L
E
T
S
-
P
T
L
F
N
-------
N
V
---
D
L
V
-----------------------
F
V
--
G
G
L
T
A
N
D
W
I
P
S
T------------
T
A
-------
E
Q
---
R
A
A
A
----
V
---
I
N
-----
G
V
-
R
-
D
G
-
T
---
I
I
L
L
H
--
D
V
----
Q
---
P
EPH
P
-
T
P
E
A
-
L
D
-
I
I
I
P
T
L
K
S
R
-
G
Y
E
F
V
T
L
T
E
L
F
T
L
K
------------
6
PsiBlast_PDB
73.22
37%
-69
- C4 -
2C71
1
?
A:
[7-190]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
T
F
D
D
G
P
D
N
------------------------
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
-
A
T
F
M
V
V
G
Q
R
-----
V
N
-----
D
-
S
T
A
A
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
-----
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
-
T
--
T
P
K
-
F
F
R
P
P
N
L
E
T
S
-
P
T
L
F
N
-------
N
V
---
D
L
V
-----------------------
F
V
--
G
G
L
T
A
N
D
W
I
P
S
-------------
T
T
A
------
E
Q
---
R
A
A
A
----
V
---
I
N
-----
G
V
-
R
-
D
G
-
T
---
I
I
L
L
H
--
D
V
QPEP
H
---
P
---
T
-
P
-
E
A
-
L
D
-
I
I
I
P
T
L
K
S
R
-
G
Y
E
F
V
T
L
T
E
L
F
T
L
K
------------
7
PsiBlast_PDB
72.00
37%
-70
- C4 -
2C79
1
?
A:
[7-190]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
T
F
D
D
G
P
D
N
------------------------
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
-
A
T
F
M
V
V
G
Q
R
-----
V
N
-----
D
-
S
T
A
A
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
-----
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
-
T
--
T
P
K
-
F
F
R
P
P
N
L
E
T
S
-
P
T
L
F
N
-------
N
V
---
D
L
V
-----------------------
F
V
--
G
G
L
T
A
N
D
W
I
P
S
-------------
T
T
A
------
E
Q
---
R
A
A
A
----
V
---
I
N
-----
G
V
-
R
-
D
G
-
T
---
I
I
L
L
H
--
D
V
QPEP
H
---
P
---
T
-
P
-
E
A
-
L
D
-
I
I
I
P
T
L
K
S
R
-
G
Y
E
F
V
T
L
T
E
L
F
T
L
K
------------
2
PsiBlast_PDB
70.00
37%
-71
- C4 -
2J13
7
?
A:
[52-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
K
--
K
D
I
Y
L
T
F
D
N
G
Y
E
N
------------------------
G
Y
T
G
K
I
L
D
V
L
K
E
K
K
V
P
-
A
T
F
F
V
T
G
H
Y
-----
I
K
-----
T
-
Q
K
D
-
L
L
L
R
M
K
D
E
G
H
I
I
G
N
H
S
W
S
H
P
D
F
T
A
V
-----
N
D
E
K
L
R
E
E
L
T
S
V
T
E
E
I
K
K
V
T
G
-
Q
--
K
E
V
K
Y
V
R
P
P
R
G
V
F
S
-
E
R
T
L
A
-------
L
T
K
E
M
G
Y
Y
----------------------
N
V
F
--
W
S
L
A
F
L
D
W
--------------------------------------------------
I
-
H
-
P
G
-
S
---
I
L
L
L
H
--
A
I
----
S
---
K
---
D
-
N
A
E
A
-
L
A
-
K
I
I
D
D
L
R
E
K
-
G
Y
H
F
K
S
L
D
D
L
V
K
S
N
------------
32
HHSearch
69.62
37%
-67
- C4 -
2J13
7
?
A:
[54-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
K
D
I
Y
L
T
F
D
N
G
Y
E
N
------------------------
G
Y
T
G
K
I
L
D
V
L
K
E
K
K
V
P
-
A
T
F
F
V
T
G
H
Y
-----
I
K
-----
T
-
Q
K
D
-
L
L
L
R
M
K
D
E
G
H
I
I
G
N
H
S
W
S
H
P
D
F
T
A
V
-----
N
D
E
K
L
R
E
E
L
T
S
V
T
E
E
I
K
K
V
T
G
-
Q
K-
E
V
K
-
Y
V
R
P
P
R
G
V
F
S
-
E
R
T
L
A
-------
L
T
K
E
M
G
Y
Y
----------------------
N
V
F
--
W
S
L
A
F
L
D
W
--------------------------------------------------
I
-
H
-
P
G
-
S
---
I
L
L
L
H
--
A
I
----
S
---
K
---
D
-
N
A
E
A
-
L
A
-
K
I
I
D
D
L
R
E
K
-
G
Y
H
F
K
S
L
D
D
L
V
K
S
N
------------
36
HHSearch
69.10
38%
-66
- C4 -
2Y8U
4
?
A:
[31-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
--
N
T
I
A
L
T
F
D
D
G
P
S
E
------------------------
Y
-
T
P
Q
L
L
D
L
L
S
R
Y
S
A
R
-
A
T
F
F
V
L
G
D
A
-----
A
A
-----
Q
-
N
P
G
-
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
-----
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
-
V
--
A
P
A
-
Y
M
R
P
P
Y
L
E
T
N
-
E
L
V
L
Q
-------
V
M
R
D
L
D
Y
R
----------------------
V
I
S
--
A
S
V
D
T
K
D
Y
E
N
Q
-------------
D
A
-------
D
A
---
I
I
N
T
----
S
---
F
Q
L
F
L
D
-
Q
L
D
A
-
G
G
-
N
---
I
V
L
A
H
--
D
I
----
H
---
Y
---
W
-
T
V
A
S
L
A
E
-
R
M
L
Q
E
V
N
A
R
-
G
L
I
A
T
T
V
G
D
C
L
G
D
G
------------
33
HHSearch
68.44
36%
-59
* C4 *
2CC0
2
?
A:
[4-188]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
G
Y
V
G
L
T
F
D
D
G
P
S
G
------------------------
S
-
T
Q
S
L
L
N
A
L
R
Q
N
G
L
R
-
A
T
M
F
N
Q
G
Q
Y
-----
A
A
-----
Q
-
N
P
S
-
L
V
R
A
Q
V
D
A
G
M
W
V
A
N
H
S
Y
T
H
P
H
M
T
Q
L
-----
G
Q
A
Q
M
D
S
E
I
S
R
T
Q
Q
A
I
A
G
A
G
G
-
G
--
T
P
K
-
L
F
R
P
P
Y
G
E
T
N
-
A
T
L
R
S
-------
V
E
A
K
Y
G
L
T
----------------------
E
V
I
--
W
D
V
D
S
Q
D
W
N
N
A
-------------
S
T
-------
D
A
---
I
V
Q
A
----
V
----
S
-----
R
L
-
G
-
N
G
-
Q
---
V
I
L
M
H
--
D
W
----
P
---
A
---
N
-
T
L
A
A
-
I
P
-
R
I
A
Q
T
L
A
G
K
-
G
L
C
S
G
M
I
S
P
Q
T
G
R
A
------------
4
PsiBlast_PDB
68.03
35%
-69
- C4 -
1W17
-
PDAA_BACSU
A:
[50-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
I
-
E
K
Y
D
A
F
Y
L
G
N
T
--
K
E
K
T
----
I
Y
L
T
F
D
N
G
Y
E
N
------------------------
G
Y
T
P
K
V
L
D
V
L
K
K
H
R
V
T
-
G
T
F
F
V
T
G
H
F
-----
V
K
-----
D
-
Q
P
Q
-
L
I
K
R
M
S
D
E
G
H
I
I
G
N
H
S
F
H
H
P
D
L
T
T
K
-----
T
A
D
Q
I
Q
D
E
L
D
S
V
N
E
E
V
Y
K
I
T
G
K
Q
--
D
N
L
-
Y
L
R
P
P
R
G
V
F
S
-
E
Y
V
L
K
-------
E
T
K
R
L
G
Y
Q
----------------------
T
V
F
--
W
S
V
A
F
V
D
W
K
I
N
-------------
N
Q
-------
K
G
K
K
Y
A
Y
D
H
----
M
---
I
K
-----
Q
A
-
H
-
P
G
-
A
---
I
Y
L
L
H
--
T
V
----
S
---
R
---
D
-
N
A
E
A
-
L
D
-
D
A
I
T
D
L
K
K
Q
-
G
Y
T
F
K
S
I
D
D
L
M
F
E
K
------------
1
PsiBlast_PDB
67.92
38%
-73
- C4 -
2Y8U
4
?
A:
[35-220]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
L
T
F
D
D
G
P
S
E
------------------------
Y
T
-
P
Q
L
L
D
L
L
S
R
Y
S
A
R
-
A
T
F
F
V
L
G
D
A
-----
A
A
-----
Q
-
N
P
G
-
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
-----
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
-
V
--
A
P
A
-
Y
M
R
P
P
Y
L
E
T
N
-
E
L
V
L
Q
-------
V
M
R
D
L
D
Y
R
----------------------
V
I
S
--
A
S
V
D
T
K
D
Y
E
N
Q
-------------
D
A
-------
D
A
---
I
I
N
T
S
F
Q
L
F
---
L
D
-----
Q
L
-
D
-
A
G
-
G
N--
I
V
L
A
H
--
D
I
----
H
---
Y
---
W
-
T
V
A
S
-
L
A
E
R
M
L
Q
E
V
N
A
R
-
G
L
I
A
T
T
V
G
D
C
L
G
D
G
------------
39
HHSearch
67.73
32%
-64
- C4 -
2IW0
6
?
A:
[40-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
--
G
L
V
A
L
T
Y
D
D
G
P
F
T
------------------------
F
T
-
P
Q
L
L
D
I
L
K
Q
N
D
V
R
-
A
T
F
F
V
N
G
N
N
-----
W
A
NIEAG
S
-
N
P
D
-
T
I
R
R
M
R
A
D
G
H
L
V
G
S
H
T
Y
A
H
P
D
L
N
T
L
-----
S
S
A
D
R
I
S
Q
M
R
Q
L
E
E
A
T
R
R
I
D
G
-
F
--
A
P
K
-
Y
M
R
A
P
Y
L
S
C
D
-
A
G
C
Q
G
-------
D
L
G
G
L
G
Y
H
----------------------
I
I
D
--
T
N
L
D
T
K
D
Y
E
N
N
-------------
K
P
ET
T
H
L
S
A
E
K
---
F
N
N
E
----
L
---
S
A
-----
D
V
G
A
-
N
S
-
Y
---
I
V
L
S
H
--
D
V
----
H
---
E
---
Q
T
V
V
S
L
-
T
Q
-
K
L
I
D
T
L
K
S
K
-
G
Y
R
A
V
T
V
G
E
C
L
G
D
A
------------
42
HHSearch
67.41
22%
-52
- C4 -
3RXZ
2
?
A:
[24-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
C
A
V
A
F
T
F
D
V
D
A
E
S
P
L
L
T
T
DPAFADR
M
G
T
M
S
H
Q
A
Y
G
P
L
V
G
V
P
R
L
L
G
I
L
D
E
F
N
V
P
-
G
T
F
F
V
P
G
Y
T
-----
A
H
-----
R
-
H
P
E
-
P
I
R
S
I
A
R
A
G
H
E
I
A
H
H
G
Y
L
H
E
S
L
V
G
A
-----
D
E
D
T
E
R
K
I
L
T
R
G
I
E
A
L
E
E
V
A
G
-
V
--
H
P
V
-
G
Y
R
A
P
M
W
E
M
N
-
W
H
T
P
K
-------
L
L
A
E
F
G
F
L
YDSTLMDSD
H
P
Y
E
L
AVGD
G
S
L
V
E
L
P
--
V
S
W
A
L
D
D
W
Q
Q
Y
C
F
V
P
DFSGTG
L
I
E
T
P
-------
A
K
---
A
I
E
L
----
W
R
A
E
L
N
-----
A
M
R
D
I
G
G
A
W
---
V
L
T
N
H
--
P
F
----
L
SGR
P
---
G
-
R
A
A
A
-
L
R
-
E
F
I
A
E
V
C
A
M
D
D
V
W
V
A
G
M
S
Q
I
A
E
H
V
------------
21
PsiBlast_CBE
66.84
38%
-67
- C4 -
2Y8U
3
?
B:
[35-220]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
L
T
F
D
D
G
P
S
E
------------------------
Y
T
-
P
Q
L
L
D
L
L
S
R
Y
S
A
R
-
A
T
F
F
V
L
G
D
A
-----
A
A
-----
Q
-
N
P
G
-
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
-----
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
-
V
--
A
P
A
-
Y
M
R
P
P
Y
L
E
T
N
-
E
L
V
L
Q
-------
V
M
R
D
L
D
Y
R
----------------------
V
I
S
--
A
S
V
D
T
K
D
Y
E
N
Q
-------------
D
A
-------
D
A
---
I
I
N
T
S
F
Q
L
F
---
L
D
-----
Q
L
-
D
-
A
G
-
G
N--
I
V
L
A
H
--
D
I
----
H
---
Y
---
W
-
T
V
A
S
-
L
A
E
R
M
L
Q
E
V
N
A
R
-
G
L
I
A
T
T
V
G
D
C
L
G
D
G
------------
9
PsiBlast_PDB
66.02
31%
-73
- C4 -
4M1B
-
?
A:
[58-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
F
T
F
D
I
S
W
G
D
------------------------
K
K
A
I
P
I
L
D
T
L
K
E
R
D
I
K
N
A
T
F
F
L
S
A
A
W
-----
A
E
-----
R
-
H
P
D
-
V
V
E
R
I
I
K
D
G
H
E
I
G
S
M
G
Y
N
Y
T
S
Y
T
S
L
-----
E
T
N
E
I
R
R
D
L
L
R
A
Q
D
V
F
T
K
L
G
V
-
K
--
Q
I
K
-
L
L
R
P
P
S
G
D
F
N
K
A
T
L
K
I
-------
A
E
---
S
L
G
----------------------
Y
T
V
V
H
W
S
N
N
S
N
D
W
K
N
P
-------------
G
V
-------
N
K
---
I
V
S
T
----
V
---
S
N
-----
N
L
-
K
-
G
G
-
D
---
I
V
L
L
H
AS
D
S
----
A
---
L
---
Q
-
T
N
K
A
-
L
P
-
L
L
L
Q
K
L
K
S
D
-
G
Y
E
Q
I
S
V
S
Q
L
I
S
N
T
------------
3
PsiBlast_PDB
65.39
37%
-59
- C4 -
2CC0
2
?
A:
[7-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
T
F
D
D
G
P
S
-------------------------
G
S
T
Q
S
L
L
N
A
L
R
Q
N
G
L
R
-
A
T
M
F
N
Q
G
Q
Y
-----
A
A
-----
Q
-
N
P
S
-
L
V
R
A
Q
V
D
A
G
M
W
V
A
N
H
S
Y
T
H
P
H
M
T
Q
L
-----
G
Q
A
Q
M
D
S
E
I
S
R
T
Q
Q
A
I
A
G
A
G
G
-
G
--
T
P
K
-
L
F
R
P
P
Y
G
E
T
N
-
A
T
L
R
S
-------
V
E
A
K
Y
G
L
T
----------------------
E
V
I
--
W
D
V
D
S
Q
D
W
N
N
A
-------------
S
T
-------
D
A
---
I
V
Q
A
----
V
---
S
R
------
L
-
G
-
N
G
-
Q
---
V
I
L
M
H
--
D
W
----
P
---
A
---
N
-
T
L
A
A
-
I
P
-
R
I
A
Q
T
L
A
G
K
-
G
L
C
S
G
M
I
S
P
Q
T
G
R
A
------------
22
PsiBlast_CBE
65.38
37%
-62
- C4 -
2CC0
2
?
B:
[7-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
T
F
D
D
G
P
S
-------------------------
G
S
T
Q
S
L
L
N
A
L
R
Q
N
G
L
R
-
A
T
M
F
N
Q
G
Q
Y
-----
A
A
-----
Q
-
N
P
S
-
L
V
R
A
Q
V
D
A
G
M
W
V
A
N
H
S
Y
T
H
P
H
M
T
Q
L
-----
G
Q
A
Q
M
D
S
E
I
S
R
T
Q
Q
A
I
A
G
A
G
G
-
G
--
T
P
K
-
L
F
R
P
P
Y
G
E
T
N
-
A
T
L
R
S
-------
V
E
A
K
Y
G
L
T
----------------------
E
V
I
--
W
D
V
D
S
Q
D
W
N
N
A
-------------
S
T
-------
D
A
---
I
V
Q
A
----
V
---
S
R
------
L
-
G
-
N
G
-
Q
---
V
I
L
M
H
--
D
W
----
P
---
A
---
N
-
T
L
A
A
-
I
P
-
R
I
A
Q
T
L
A
G
K
-
G
L
C
S
G
M
I
S
P
Q
T
G
R
A
------------
34
HHSearch
64.82
29%
-47
- C4 -
2W3Z
3
?
A:
[68-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
P
N
A
L
K
I
G
S
N
HNNQA
E
G
Y
A
Y
S
A
E
T
V
R
Q
M
M
N
N
-----
Q
--
K
L
V
F
L
T
F
D
D
G
V
D
P
------------------------
N
M
T
P
K
I
L
D
V
L
A
Q
Q
H
V
H
-
A
T
F
F
L
V
G
C
N
-----
I
T
-----
D
K
V
K
P
-
I
L
Q
R
Q
I
T
E
G
H
A
L
G
I
H
S
F
S
H
V
Y
S
L
L
Y
PNRVG
N
T
Q
Q
I
V
S
E
V
T
R
T
Q
N
A
L
K
D
Q
L
G
-
Q
NF
K
T
G
-
V
W
R
Y
P
G
G
H
L
S
-
W
T
G
L
E
A
A
D
K
Q
L
A
A
Q
---
G
I
Q
----------------------
W
M
D
--
W
N
A
A
V
G
D
A
E
P
L
ATRPT--------
T
V
-------
A
S
---
M
L
A
F
----
L
---
D
G
S
A
K
IA
T
N
-
P
-
N
V
-
Q
---
V
V
L
M
H
--
D
I
----
S
---
E
K
T
-
I
-
T
L
A
S
-
L
P
-
Q
I
I
R
Y
Y
K
D
R
-
G
Y
T
F
A
V
L
K
------------------
23
PsiBlast_CBE
64.80
31%
-74
- C4 -
4M1B
1
?
B:
[58-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
F
T
F
D
I
S
W
G
D
------------------------
K
K
A
I
P
I
L
D
T
L
K
E
R
D
I
K
N
A
T
F
F
L
S
A
A
W
-----
A
E
-----
R
-
H
P
D
-
V
V
E
R
I
I
K
D
G
H
E
I
G
S
M
G
Y
N
Y
T
S
Y
T
S
L
-----
E
T
N
E
I
R
R
D
L
L
R
A
Q
D
V
F
T
K
L
G
V
-
K
--
Q
I
K
-
L
L
R
P
P
S
G
D
F
N
K
A
T
L
K
I
-------
A
E
---
S
L
G
----------------------
Y
T
V
VH
W
S
N
N
S
N
D
W
K
N
P
-------------
G
V
-------
N
K
---
I
V
S
T
----
V
---
S
N
-----
N
L
-
K
-
G
G
-
D
---
I
V
L
L
H
AS
D
S
----
A
---
L
---
Q
-
T
N
K
A
-
L
P
-
L
L
L
Q
K
L
K
S
D
-
G
Y
E
Q
I
S
V
S
Q
L
I
S
N
T
------------
8
PsiBlast_PDB
61.54
32%
-56
- C4 -
2IW0
6
?
A:
[44-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
T
Y
D
D
G
P
-
F
------------------------
T
F
T
P
Q
L
L
D
I
L
K
Q
N
D
V
R
-
A
T
F
F
V
N
G
N
N
WANIE
A
G
-----
S
-
N
P
D
-
T
I
R
R
M
R
A
D
G
H
L
V
G
S
H
T
Y
A
H
P
D
L
N
T
L
-----
S
S
A
D
R
I
S
Q
M
R
Q
L
E
E
A
T
R
R
I
D
G
-
F
--
A
P
K
-
Y
M
R
A
P
Y
L
S
C
D
-
A
G
C
Q
G
D
------
L
G
---
G
L
G
----------------------
Y
H
I
I
D
T
N
L
D
T
K
D
Y
E
N
N
-------------
K
P
-------
E
T
---
T
H
L
S
----
A
---
E
K
F
N
N
E
L
S
A
-
D
-
V
G
-
A
N
S
Y
I
V
L
S
H
--
D
V
----
H
E--
Q
---
T
-
V
V
S
L
-
T
Q
-
K
L
I
D
T
L
K
S
K
-
G
Y
R
A
V
T
V
G
E
C
L
G
D
A
------------