@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0870: (2015-12-03 )
MDNTVIVHYHSRKKNYFNLSLWQWRDGSEGQDAHFSRFDSFGAVAILKYPLPYFLSHYYVIVKDKNWHHKTIDYRIDCTKGGARKEVWIVDGDDNLYYSRQAAVSSHHYSRRQPHAYDMAINSRAFDKKWGFDGWLGFEYSETKTAFRLWAPTAERVELILYHSTDETASVSKVLSMKRGTAVNYKNHKENTHGVWFTELEGNYNYQAYTYRVYYRRRTFKITRDPYSIATTANGKRSIVIAPEALTPEGFKISHGKEAKWRLENPNQAVIYEMHVRDFSISETSGVKTDYQGKFKGLHQKDTVNQHGDKTTFDYVQDLGVNYIQLQPIFDHHQTFDDDGHYAYNWGYDPENYNVPEASFSSNPHEPATRILELKSAIQAYHDAGIGVIMDVVYNHTFSSTDSAFQLTVPDYYYRMNHNGTFQNGSGCGNETASEKEMCRKYILDSVLYWVKEYNIDGFRFDLMGLHDVETMNIIRNELNKIDPRILVYGEGWDMGAGLTPQNKAKKDNAYQMPGIGFFNDDVRDAVKGAEIYGEFKKGLVSGNSTEDIVAKGILGSDELVSYIDPSQVLNYIEAHDNYNLNDLLWELHPNDNEKQHIYRVEVASAMNLLMQGMAFMQLGQEFLRTKCYPTGDKGQLTQADKERAMNSYNAPDQVNQVNWDNVTFHKSTINFIRKIITLKTNSPYFSYSSFEEIRKHVFVESAQYHSGFISFTVEEHKKIKIIFNIKGKRLQNPFIGDIIISNHEEGKAIDSLDDELSVMIFDITK
Atome Classification :
(20 SA)
------------------.........10------.........20.......-----------.-----------30........40........50........60........70..--......80........90........100.--------------....-----------------------------------------------------------.-------------.110------------------------------.....-----------------------------------....-----------------------------------120....---------...130.--.-.---....140-.--.--......150.......160.......170.......180.......190.......200--.-------.-----......210....-----.------.---------.220-.......230--------...------------.-----------------------------.----.------------...240-....--....250.......260-----.----......270.......280......--.290.-.......300.......310.........320.......330--------.--------.....--.--.340------------------------------------------------------------...---------......350.......360...-----------------------------------------------------....370.......380-..-.....390.......400--..----.----.....-.410......-.-420.......430.......440.......450.......460.......470---.........480-........490.-----.....--.500--.......510.......520.......-----530.....-----..540.----------------.-.-.---------------.-..550.....----.---.560---------------------.--...-.-----------------------....570.......580......---.590.-----.-----------------------------......-----600.......610........620.....-----..-------630.------------.---------------.-..-------------------..640..---------------..---...650.......660..------.---------------------------------...------.670.......680.......690...-------....700----....----------.....710..-----------.-------------.-----------...720.......730....--------.----.----.740..-----.....750..---------------.....-----760....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------MDN
T
V
I
V
H
Y
H-------SRKK
N
Y
FNL
S
L
W
Q
WRDGS-----------E-----------GQ
D
A
H
F
S
R
F
DSF
G
A
V
A
I
LKY
P
L
P
Y
F
L
S
H
Y
Y
V
I
V
KDKNW
H
H
K
T
I
D
--
Y
R
I
DCTKGGA
R
K
E
V
W
I
V
DGDD
N
L
Y
Y
S
R
Q
A
A
--------------VSSH-----------------------------------------------------------H-------------YS--------------------------------RRQP
H
-----------------------------------
A
Y
D
M
-----------------------------------AINSRAF---------DKKWGFD--
G
-
W
---
L
G
F
E
YS--E--T--
K
T
A
F
R
L
WAP
T
A
E
R
V
E
L
I
L
Y
HSTDE
T
A
S
V
S
K
V
L
S
MKRG
T
A
VNYKNHKENTH
G
V
W
F
T
E
LE---G-------N-----Y
N
Y
Q
A
Y
T
Y
R
V
Y
Y
R
-----
R
------
R
---------
T
F
K
I-TRDP
Y
S
I
A
----------TTA------------N-----------------------------G----
K
------------
R
S
I
V
I--APEA--LTPE
G
F
KISHGKE
A
K
W
R
-----L----ENPN
Q
A
V
I
Y
E
M
H
V
R
DFSISETSGVK--TDY-Q-GKFKGLHQKDTVNQHGDK--
T
T
F
D
Y
V
Q
D
LGV
N
Y
I
Q
L
Q
P
IFD---------H--------HQTFD--D--DG--------------------------------------------------------------
H
Y
A
---------
Y
NWGYDPENYNVPEASFSSNPH-----------------------------------------------------
E
P
A
T
R
I
L
E
L
K
S
A
I
Q
A
Y
H
-DA-
G
I
G
V
I
M
D
V
V
YNHTFSS----TD----
S
----
A
F
Q
L
T-VP
D
Y
Y
Y
R
MNH-N-GTFQNGSGCGNETA
S
E
K
E
M
C
R
K
Y
I
L
D
S
V
L
Y
W
V
K
EYNID
G
F
R
F
D
LMGLH
D
V
E
-----
T
M
N
I
I
R
N
E
L
NK--ID
P
R
I
L
V
Y
GEGW-----DMGAG--LTPQ--NKAKKDNAYQMPGIGFF
N
D
D
V
R
D
A
V
K
G
-----
A
E
I
Y
G
E
F
K
-----
K
G
LVSG----------------N-S-
T
---------------
E
-
D
I
V
A
KGIL
G
S
----
D
---
E
L
-----------------------
V
--
S
YI-
D
-----------------------
P
S
Q
V
L
N
Y
I
E
AHDNY
N
L
N
D
L
L
W
E
L---HPN-D-----N-----------------------------E
K
Q
H
I
Y
-----
R
V
E
V
A
S
A
M
N
L
L
M
-
Q
G
M
A
F
M
Q
L
G
Q
E
F
L
RTK-----CY-------PTGD------------K---------------G-QL-------------------
T
Q
A
D
K
E
R
---------------AM---NSYNAPDQVNQVNWDN
V
T
------
F
---------------------------------
H
K
S
------
T
I
N
F
I
R
K
I
I
T
LKTNSPYFSYS
S
F
E
E
I
R
-------
K
H
V
F
V------ESAQ----------YHS
G
F
I
S
F
T
V-----------E-------------E-----------H
K
K
I
K
I
I
F
NIKGKRLQNPFI--------
G
----
D
----
I
I
ISNH-----EEGKAIDSLD---------------DE
L
S
V
-----
M
I
F
DITK--------------
55
Fugue
90.27
32%
-60
- C1 -
2E8Y
3
PULA_BACSU
A:
[1-712]
------------------
M
V
S
I
------------------------------
R
-----------
R
-----------
S
F
E
A
Y
V
D
D
M
N
--
I
I
T
V
L
I
P
A
E
Q
K
E
I
M
T
P
P
F
R
L
E
T
E
I
----
T
D
F
P
--
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
S
D
H
P
V
T
F
G
K
I
H
C
--------------
V
R
A
S
-----------------------------------------------------------
S
-------------
G
H
--------------------------------
K
T
D
L
------------------------------------
Q
I
G
A
-----------------------------------
V
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
----
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
----------------
E
W
M
E
-
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
K
W
T
A
P
L
K
P
-------------
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
----
N
-
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
------
N
T
F
H
L
K
A
-----
T
G
F
A
L
G
N---------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
SGWK
A
---
L
A
-----------------------
P
--
I
V
P
-
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
--------------------------------------------------------------------------
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
------------
E
H
L
I
A
Y
R
L
-----------
Y
DLDEVD-------
E
-----------
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
--------
N
----
D
IPYR
L
L
C
D
P
S
-----
G
F
Q
E
D
P
T
E
I
K
---------------
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
--------------
34
HHSearch
86.88
29%
-62
- C1 -
2FHF
7
PULA_ENTAE
A:
[51-1026]
-------------------
A
R
Q
A
V
I
H
L
V
D
I
A
G
ITS
S
T
P
A
D
Y
A
T
K
N
L
Y
L
W
N
N
E
T
-----------
C
DALSAPVADWN
D
V
S
T
T
P
T
G
S
D
K
Y
G
P
Y
W
V
I
P
L
T
K
--
E
S
G
C
I
N
V
I
V
R
D
G
T
N
--
K
L
I
D
S
D
L
R
V
S
-
F
S
D
F
T
D
R
T
V
S
V
I
A
G
N
S
A
V
Y
D
S
R
A
D
A
F
R
A
AFGVALADAHW
V
D
K
T
-----------------------------------------------------------
T
L
L
W
PGGENKP
I
V
R
L
Y
Y
S
HS
S
K
V
A
A
D
SNGEFS
D
K
Y
V
K
L
T
P
T
T
V
N
Q
Q
V
S
M
R
F
P
H
LAS
Y
P
A
F
K
L
P
DDVN
V
D
E
L
L
Q
G
E
T
V
A
I
A
A
E
SDGILS
S
A
T
Q
-----------------------------------
V
Q
T
A
G
V
L
---------
D
D
T
Y
A
A
A
A
E
A
L
S
---
Y
G
A
Q
L
T
--
D
--
S
--
G
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
S
A
D
K
K
---
V
I
A
S
H
P
M
T
R
D
S
----------
A
S
G
A
W
S
W
Q
G
G
---
S
-------
D
-----
L
K
G
A
F
Y
R
Y
A
M
T
V
Y
-----
H
PQSRKV
E
---------
Q
Y
E
--
V
T
D
P
Y
A
H
S
----------
L
S
T
------------
N
-----------------------------
S
----
E
------------
Y
S
Q
V
V
--
D
L
N
D
SA
L
K
P
E
G
W
D
G
L
T
M
----
P
H
-----
A
QKT
K
A
D
L
A
K
M
T
I
H
E
S
H
I
R
D
L
S
A
W
D
Q
T
-
V
P
--
A
E
L
-
R
-
G
K
Y
L
A
L
T
A
Q
E
S
----
N
M
V
--
Q
H
L
K
Q
L
S
A
S
G
V
T
H
I
E
L
L
P
V
F
D
---------
L
--------
A
-
T
V
N
--
E
--
F
S
DKVADIQQP
F
S
R
L
C
E
V
N
SAVKSSEFAGYCDSGST
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
D
S
---------
Y
N
W
G
Y
D
P
F
H
Y
T
V
P
E
G
S
Y
A
T
D
P
------------------------------------------------------
E
G
T
A
R
I
K
E
F
R
T
M
I
Q
A
I
K
Q
D
L
-
G
M
N
V
I
M
D
V
V
Y
N
H
T
N
A
A
----
G
P
TDRT
S
----
V
L
D
K
I
-
V
P
W
Y
Y
Q
R
L
N
E
-
T
T
G
S
V
E
S
A
T
C
C
-
S
D
S
A
P
E
H
R
M
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
L
Y
H
P
K
A
-----
Q
I
L
S
A
W
E
R
I
K
A
--
L
N
P
D
I
Y
F
F
G
E
G
W
-----
D
S
N
Q
S
--
D
R
-
F
--
E
I
A
S
Q
I
N
L
-
K
G
T
G
I
G
T
F
S
D
R
L
R
D
A
V
R
G
-----
G
G
P
F
D
S
G
D
A
L
R
Q
N
Q
G
V
G
S
G
----------------
A
-
G
V
L
PNELTTLS
D
D
Q
A
R
H
L
A
-
D
L
T
R
L
G
M
A
G
N
----
L
---
A
D
F
V
L
I
D
KDG
A
V
K
R
GSEIDYNGAPG
G
--
Y
A
A
-
D
-----------------------
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
M
I
S
Y
K
---
A
A
Q
E
A
-----
D
-----------------------------
L
D
T
R
V
R
-----
M
Q
A
V
S
L
A
T
V
M
L
G
-
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
-----
S
F
------------------------------------------------------------------------------------
T
R
---
D
S
Y
D
S
G
D
W
F
N
R
V
D
Y
S
L
Q
D
------
N
NYNVGMPRSSDDGSN
Y
D
I
I
A
R
V
KDAVATPG
E
T
E
L
K
Q
------
M
T
A
F
Y
Q
E
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
-------
K
R
V
D
F
------
R
N
T
G
AD--------
Q
Q
T
G
L
L
V
M
T
I
-----------
D
-------------
D
GMQAGASLDSR
V
D
G
I
V
V
A
I
N
A
A
P
E
S
R
T
L
Q
D
F
--------
A
----
G
----
T
S
L
Q
L
S
-----
A
I
Q
Q
A
A
G
D
R
S
---------------
L
A
S
G
V
-----
Q
V
A
A
D
G
S
--------------
36
HHSearch
85.30
35%
-63
* C1 *
2E8Y
3
PULA_BACSU
A:
[54-689]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
K
Y
K
Y
V
C
V
S
D
H
P
V
T
F
G
K
I
H
C
--------------
V
R
A
S
-----------------------------------------------------------
S
-------------
G
---------------------------------
H
K
T
D
L
-----------------------------------
Q
I
G
A
-----------------------------------
V
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
L
-----------
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
-----
M
K
W
T
A
P
L
K
----
P
F
-----
S
-----
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
----
N
-
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
-
G
V
D
--
E
--
E
K
P-------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
------
G
N
T
F
H
L
K
A
-----
T
G
F
A
L
G
----------------
N
-
G
E
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
---
G
W
KALA-------------------
P
--
I
V
P
-
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
-----
Q
G
------------------------------------------------------------------------------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
------------
K
E
H
L
I
A
Y
R
L
-----------
Y
-------------
D
LDEVDE-----
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
--------
N
DIPY
R
----
L
L
C
D
P
S
-----
G
F
Q
E
D
P
T
E
I
K
---------------
K
T
V
A
V
-----
N
G
I
G
T
V
I
--------------
35
HHSearch
81.74
29%
-55
- C1 -
3FAW
9
?
A:
[120-785]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
W
E
F
K
---------
D
Q
L
Y
A
Y
S
--
G
-
N
---
L
G
A
V
L
N
--
Q
--
D
GS
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
-
V
V
A
T
T
P
L
V
K
N
-----------
N
K
G
V
W
Q
T
I
L
D
---
T
KLGIK--
N
-----
Y
T
G
Y
Y
Y
L
Y
E
I
K
R
G
-----
K
------
D
---------
K
V
K
--
I
L
D
P
Y
A
K
S
----------
L
A
E
------------
W
-----------------------------
D
----
S
NTVNDDIK
T
A
--
K
A
A
F
V
--
N
P
S
Q
--
L
G
P
Q
N
L
S
F
A
K
I
----
A
N
-----
F
----
K
G
R
Q
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
D
G
K
L-
K
N
Q
-
L
-
G
T
F
A
A
F
-----------
S
--
E
K
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
--------
F
-
Y
V
N
--
E
--
M
D
KSRSTAYTSS----------------------------------------------------
D
N
N
---------
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
-
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
T
----------
Y
----
L
F
E
D
I
-
E
P
N
Y
Y
H
F
M
N
E
-
D
-
G
S
P
R
E
S
F
G
G
-
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
A
I
E
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
-----
R
T
F
Q
G
--
D
Q
G
K
PV
K
P
A
D
Q
D
W
M
K
S
T
D
T
V
G
V
F
S
D
D
I
R
N
S
L
K
------
S
G
F
P
N
E
G
T
-----
P
A
F
I
T
G
----------------
G
-
P
Q
S
---------------
L
-
Q
G
I
F
K
N
I
K
A
Q
----
P
---
G
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
---
I
N
K
-
D
PKV--
A
-----------------------------
E
E
D
I
H
R
-----
R
L
R
L
G
N
V
M
I
L
T
S
-
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
R
L
-------
L
N
P
D
------------
Y
MTKVSDDKLPNKATL
I
-
E
A
-------------------
V
K
E
Y
P
Y
F
---------------
I
H
---
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
T
------
D
NNKH
P
I
---------------------------
S
T
K
------
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
------
I
T
E
V
GQGDIK----
E
K
D
L
V
I
A
Y
Q
T
-----------
I
-------------
D
SK---------
G
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
N
V
L
L
G
EKY
K
H
L
L
K
G
----
Q
----
V
I
V
D
A
D
-----
Q
A
G
I
K
P
I
S
T
P
---------------
R
G
V
H
F
-----
E
K
D
S
L
L
I
--------------
38
HHSearch
81.48
28%
-54
- C1 -
2YA0
7
?
A:
[2-676]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
L
K
---------
D
E
T
Y
S
Y
D
--
G
-
K
---
L
G
A
D
L
K
--
E
EG
K
--
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
K
-
V
V
G
T
V
A
L
E
K
G
-----------
E
R
G
T
W
K
Q
T
L
D
---
S
TNKLGIT
D
-----
F
T
G
Y
Y
Y
Q
Y
Q
I
E
R
Q
-----
G
------
K
---------
T
V
L
--
A
L
D
P
Y
A
K
S
----------
L
A
A
------------
W
-----------------------------
N
----
S
DDSKIDDAHK
V
A
K
A
A
F
V
--
D
P
A
K
--
L
G
P
Q
D
L
T
Y
G
K
I
----
H
N
-----
F
----
K
T
R
E
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
P
A
I
A
K
D
L-
T
K
P
-
F
-
G
T
F
E
A
F
-----------
I
--
E
K
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
--------
Y
-
F
V
N
--
E
--
L
K
NHERLSDYASS---------------------------------------------------
N
S
N
---------
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
K
-----------------------------------------------------
N
P
E
K
R
I
A
E
F
K
N
L
I
N
E
I
H
-
K
R
-
G
M
G
A
I
L
D
V
V
Y
N
H
T
A
K
V
----------
D
----
L
F
E
D
L
-
E
P
N
Y
Y
H
F
M
D
A
-
D
-
G
T
P
R
T
S
F
G
-
G
G
R
L
G
T
T
H
H
M
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
S
I
E
E
A
Y
K
A
A
R
A
--
L
N
P
N
L
I
M
L
G
E
G
W
-----
R
T
Y
A
G
--
D
E
N
M
P
T
K
A
A
D
Q
D
W
M
K
H
T
D
T
V
A
V
F
S
D
D
I
R
N
N
L
K
------
S
G
Y
P
N
E
G
Q
-----
P
A
F
I
T
G
----------------
G
-
K
R
D
---------------
V
-
N
T
I
F
K
N
L
I
A
Q
----
P
---
T
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
I
I
A
Q
S
---
I
K
K
-
D
PSK
A
E
N
-----------------------------
Y
A
E
I
H
R
-----
R
L
R
L
G
N
L
M
V
L
T
A
-
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
Q
F
-------
R
N
P
A
------------
Y
---------------
R
-
T
P
VAEDKVPNK
S
H
L
L
R
D
KDGN
P
F
D
Y
P
Y
F
---------------
I
H
---
D
S
Y
D
S
S
D
A
V
N
K
F
D
W
T
K
A
T
------
D
GKAY
P
E
---------------------------
N
V
K
------
S
R
D
Y
M
K
G
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
-------
D
R
V
H
L
------
I
T
V
P
GQNGVE----
K
E
D
V
V
I
G
Y
Q
I
-----------
T
-------------
A
PN---------
G
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
E
F
N
L
G
TAFAHLRN
A
----
E
----
V
L
A
D
E
N
-----
Q
A
G
P
V
G
I
A
N
P
---------------
K
G
L
E
W
-----
T
E
K
G
L
K
L
--------------
57
Fugue
81.38
26%
-48
- C1 -
3FAW
9
?
A:
[37-814]
------------------
Q
V
Q
L
K
D
A
Q
Q
T
-------
D
L
T
S
I
Q
A
S
F
T
T
L
D
K
T
E
I
L
-----------
K
-----------
E
-----------------------------
L
K
V
T
D
K
N
Q
N
A
I
Q
-----
I
S
D
I
T
L
D
T
S
K
S
L
L
I
I
K
G
D
F
N
P
K
Q
G
H
F
N
I
S
--------------
Y
N
G
N
-----------------------------------------------------------
N
-------------
V
T
--------------------------------
T
------------------------------------------------------------------------------
R
Q
S
W
E
F
K
---------
D
Q
L
Y
A
Y
S
--
G
-
N
---
L
G
A
V
L
N
--
Q
DG
S
--
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
L
------------
V
K
N
N
K
G
V
W
Q
T
I
L
D
---
T
-------
K
LGIKN
Y
T
G
Y
Y
Y
L
Y
E
I
K
R
G
-----
K
------
D
---------
K
V
K
I
-
L
-
D
P
Y
A
K
S
LAEWDSNTVN
D
D
I
------------
K
-----------------------------
T
----
A
------------
K
A
A
F
V
--
N
P
S
Q
--
L
G
P
Q
N
L
S
F
A
K
I
A
N
---------
F
----
K
G
R
Q
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
D
G
K
--
L
K
N
Q
L
-
G
T
F
A
A
F
S
E
K
-------------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
YFYVNEMDK
S
--------
R
S
T
A
Y
--
T
--
S
S
--------------------------------------------------------------
D
N
N
---------
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
-
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
T
----------
Y
----
L
F
E
D
I
-
E
P
N
Y
Y
H
F
M
N
E
-
D
-
G
S
P
R
E
S
-
F
G
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
A
I
E
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
-----
R
T
F
Q
G
D
Q
G
K
P
V
--
K
P
A
D
Q
D
W
M
K
S
T
D
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
------
G
F
P
N
E
G
T
-----
P
A
F
I
T
G
----------------
G
P
Q
-
S
---------------
L
-
Q
G
I
F
K
N
I
K
A
Q
----
P
---
G
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
I
NK
D
P
K
-
V
-----
A
-----------------------------
E
E
D
I
H
R
-----
R
L
R
L
G
N
V
M
I
L
T
S
-
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
R
L
-------
L
N
P
D
------------
Y
---------------
M
-
T
K
-------------------
V
S
D
D
K
L
P
NKATLIEAVKEYPYF
I
H
---
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
T
DNNKH
P
I
---------------------------------
S
T
K
------
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
ITEVGQ
G
D
I
K
----------
E
K
D
L
V
I
A
Y
Q
T
-----------
I
D
S-----------
K
-----------
G
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
N
V
L
L
G
--------
E
----
K
----
Y
K
H
L
L
K
GQVIV
D
A
D
Q
A
G
I
K
P
I
---------------
S
T
P
R
G
-----
V
H
F
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
22
PsiBlast_CBE
81.00
35%
-57
- C1 -
2E8Z
4
PULA_BACSU
B:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
APLKP
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
21
PsiBlast_CBE
80.78
35%
-58
- C1 -
2E9B
3
PULA_BACSU
B:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
APLKP
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
1
PsiBlast_PDB
80.35
35%
-57
- C1 -
2E8Y
3
PULA_BACSU
A:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
A
P
L
K
P
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
4
PsiBlast_PDB
80.29
36%
-55
- C1 -
3WDJ
5
?
A:
[88-632]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------
Q
V
G
A
-----------------------------------
V
M
R
T
K
A
F
---------
D
D
L
Y
A
Y
D
--
G
-
N
D--
L
G
A
T
Y
D
--
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
T
T
Y
V
M
T
R
E
K
K
G
--------------
L
W
T
Y
T
V
Y
---
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
-----
F
----------------
I
W
R
E
-
A
V
D
P
Y
A
K
S
----------
V
S
V
------------
N
-----------------------------
G
----
T
------------
Y
G
V
V
V
-----------
D
L
A
K
T
N
I
P
K
P
S
M
S
L
-----
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
--
Q
---
K
-
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
--
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
--------
E
G
V
D
E
--
L
--
Q
P
--------------------------------------------------------------
L
K
M
---------
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
D
-----------------------------------------------------
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
-
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
----
E
T
----
S
----
S
F
E
H
L
-
V
P
G
Y
Y
F
R
Y
E
R
-
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
-----
T
M
N
D
V
R
R
A
I
D
E
--
I
D
P
T
V
I
I
L
G
E
G
W
-----
D
L
A
T
P
--
L
P
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
-----
S
-
T
F
D
I
H
E
-----
R
G
F
A
L
G
----------------
D
-
C
-
S
Y--------------
K
-
E
A
V
I
G
A
I
R
G
S
----
I
---
H
L
---------------------------
F
F
-
S
-----------------------
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
H
-
E
-----
S
-----------------------------
E
Y
I
R
R
K
-----
R
Q
K
L
A
T
A
I
V
L
L
S
-
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
------------------------------
K
---------------
G
--------------------------------------------
V
E
---
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
S
------
R
---------------------------------
W
E
E
------
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
-------
R
H
M
K
F
------
Y
D
T
H
----------
P
S
V
I
A
Y
Q
L
V
D
-----------
V
-------------
G
-----------
V
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
--------
L
----
P
----
L
A
D
G
K
W
-----
K
V
M
F
S
S
L
G
N
V
---------------
C
E
Q
F
I
-----
E
I
N
G
I
G
A
--------------
59
Fugue
80.21
24%
-60
- C1 -
2FHF
7
PULA_ENTAE
A:
[32-1083]
D
V
V
V
R
L
PDVAVPGEA
V
Q
A
S
A
R
Q
A
V
I
H
L
V
D
I
A
G
ITS
S
T
P
A
D
Y
A
T
K
N
L
Y
L
W
N
N
E
T
CDALSAPVADW
N
-----------
D
V
S
T
T
P
T
G
S
D
K
Y
G
P
Y
W
V
I
P
--
L
T
K
E
S
G
C
I
N
V
I
V
R
D
G
T
N
K
L
I
D
S
D
--
L
R
V
S
F
S
D
F
T
-
D
R
T
V
S
V
I
A
G
N
S
A
V
Y
D
S
R
A
D
A
--------------
F
R
A
A
FGVALADAHWVDKT
T
L
L
W
PGGENKP
I
V
R
L
Y
Y
S
HS
S
K
V
A
A
D
SNGEFS
D
K
Y
V
K
L
T
P
T
T
V
N
Q
Q
-------------
V
S
--------------------------------
M
R
F
P
H
-----------------------------------
L
A
S
Y
P
A
F
K
L
P
DDVN
V
D
E
L
L
Q
G
E
T
V
A
I
A
A
E
SDGILS
S
A
T
Q
V
Q
T
A
G
V
L
---------
D
D
T
Y
A
A
A
--
A
-
E
A
L
S
Y
G
A
Q
L
T
--
D
--
S
--
G
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
S
A
D
K
K
V
I
A
S
H
P
M
-------------
T
R
D
S
A
S
G
A
W
S
W
Q
G
G
---
S
-------
D
-----
L
K
G
A
F
Y
R
Y
A
M
T
V
Y
HPQSR
K
------
V
---------
E
Q
Y
E
-
V
T
D
P
Y
A
H
S
----------
L
S
T
------------
N
-----------------------------
S
----
E
------------
Y
S
Q
V
V
D
L
N
D
S
A
--
L
K
P
E
G
W
D
G
L
T
M
P
H
A
Q
K
T
-----
K
----
A
D
L
A
K
M
T
I
H
E
S
H
I
R
D
L
S
A
W
D
Q
T
-
V
P
--
A
E
L
-
R
-
G
K
Y
L
A
L
T
A
Q
E
S
----
N
M
V
--
Q
H
L
K
Q
L
S
A
S
G
V
T
H
I
E
L
L
P
V
F
D
LATVNEF--
S
--------
D
K
V
A
D
--
I
--
Q
Q
--------------------------------------------------------------
P
F
S
---------
R
L
C
E
V
N
S
A
V
K
S
S
E
F
A
G
Y
C
D
S
G
S
T
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
DSYNWGYDPFHYTVPEGSYATDP
E
G
T
A
R
I
K
E
F
R
T
M
I
Q
A
I
K
-
Q
D
L
G
M
N
V
I
M
D
V
V
Y
N
H
T
N
A
A
GPTD
R
T
----
S
----
V
L
D
K
I
-
V
P
W
Y
Y
Q
R
L
N
E
-
T
-
T
G
S
V
E
S
A
T
C
C
S
D
S
A
P
E
H
R
M
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
L
Y
H
P
K
A
-----
Q
I
L
S
A
W
E
R
I
K
A
--
L
N
P
D
I
Y
F
F
G
E
G
W
-----
D
S
N
Q
S
----
D
R
--
F
E
I
A
S
Q
I
N
L
K
G
T
G
I
G
T
F
S
D
R
L
R
D
A
V
R
G
GGPFD
S
G
D
A
L
R
Q
N
-----
Q
G
V
G
S
G
AGVLPNELTTLS
D
D
Q
A
R
-
H
-
L
---------------
A
-
D
L
T
R
L
G
M
A
G
N
----
L
---
A
D
-----------------------
F
--
V
L
I
-
D
KDG
A
V
K
R
GSEIDYNGAPG
G
Y
A
AD
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
M
I
S
Y
K
---
A
A
Q
-
E
-----
A
-----------------------------
D
L
D
T
R
V
-----
R
M
Q
A
V
S
L
A
T
V
M
L
G
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
SFTRD
S
Y
-------
D
S
G
D
------------
W
---------------
F
N
R
V
-------------------
D
Y
S
L
Q
D
N
---------------
N
Y
---
N
V
G
M
P
R
S
S
D
D
G
S
N
Y
D
I
I
A
------
R
V
KDAVATPG
E
T
E
---------------------
L
K
Q
------
M
T
A
F
Y
Q
E
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
-------
K
R
V
D
F
R
N----
T
G
A
D
----------
Q
Q
T
G
L
L
V
M
T
I
D
DGMQAGASLD
S
-------------
R
-----------
V
D
G
I
V
V
A
I
N
A
A
P
E
S
R
T
L
Q
D
F
--------
A
----
G
----
T
S
L
Q
L
S
-----
A
I
Q
Q
A
A
G
D
R
S
LASG
V
Q
V
A
ADG
S
V
T
L
P
A
W
S
V
-----
A
V
L
E
L
P
Q
G
ESQGAGLPVSSK-
2
PsiBlast_PDB
80.20
35%
-57
- C1 -
2E8Z
4
PULA_BACSU
A:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
A
P
L
K
P
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
23
PsiBlast_CBE
79.69
35%
-57
- C1 -
2E8Y
3
PULA_BACSU
B:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
APLKP
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
5
PsiBlast_PDB
79.30
36%
-56
- C1 -
3WDI
5
?
A:
[88-632]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------
Q
V
G
A
-----------------------------------
V
M
R
T
K
A
F
---------
D
D
L
Y
A
Y
D
--
G
-
N
D--
L
G
A
T
Y
D
--
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
T
T
Y
V
M
T
R
E
K
K
G
--------------
L
W
T
Y
T
V
Y
---
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
-----
F
----------------
I
W
R
E
-
A
V
D
P
Y
A
K
S
----------
V
S
V
------------
N
-----------------------------
G
----
T
------------
Y
G
V
V
V
-----------
D
L
A
K
T
N
I
P
K
P
S
M
S
L
-----
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
--
Q
---
K
-
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
--
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
--------
E
G
V
D
E
--
L
--
Q
P
--------------------------------------------------------------
L
K
M
---------
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
D
-----------------------------------------------------
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
-
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
----
E
T
----
S
----
S
F
E
H
L
-
V
P
G
Y
Y
F
R
Y
E
R
-
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
-----
T
M
N
D
V
R
R
A
I
D
E
--
I
D
P
T
V
I
I
L
G
E
G
W
-----
D
L
A
T
P
--
L
P
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
-----
S
-
T
F
D
I
H
E
-----
R
G
F
A
L
G
----------------
D
-
C
-
S
Y--------------
K
-
E
A
V
I
G
A
I
R
G
S
----
I
---
H
L
---------------------------
F
F
-
S
-----------------------
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
H
-
E
-----
S
-----------------------------
E
Y
I
R
R
K
-----
R
Q
K
L
A
T
A
I
V
L
L
S
-
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
------------------------------
K
---------------
G
--------------------------------------------
V
E
---
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
S
------
R
---------------------------------
W
E
E
------
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
-------
R
H
M
K
F
------
Y
D
T
H
----------
P
S
V
I
A
Y
Q
L
V
D
-----------
V
-------------
G
-----------
V
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
--------
L
----
P
----
L
A
D
G
K
W
-----
K
V
M
F
S
S
G
N
V
C
---------------
E
Q
F
I
E
-----
I
N
G
I
G
A
W
--------------
3
PsiBlast_PDB
79.07
35%
-58
- C1 -
2E9B
6
PULA_BACSU
A:
[91-639]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
---------
D
D
E
F
Y
Y
D
--
G
-
E
---
L
G
A
V
Y
T
--
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
----
G
R
T
F
Q
M
T
R
-----------
L
E
K
G
V
Y
A
V
T
V
T
---
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
C
N
N
-----
S
------
E
---------
W
M
E
--
T
V
D
Q
Y
A
K
A
----------
V
T
V
------------
N
-----------------------------
G
----
E
------------
K
G
V
V
L
--
R
P
D
Q
--
M
-------------
K
W
T
A
P
L
K
P
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
--
N
---
K
-
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
--
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
--------
A
G
V
D
E
--
E
--
K
P
--------------------------------------------------------------
L
D
A
---------
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
-
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
----
E
N
----
S
----
P
F
E
K
T
-
V
P
G
Y
F
F
R
H
D
E
-
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
-----
T
V
L
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
--
L
P
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-----
N
T
F
H
L
K
A
T
-----
G
F
A
L
G
N
----------------
G
-
E
-
S
---------------
A
-
Q
A
V
M
H
G
I
A
G
S
----
S
GWK
A
L
-----------------------
A
--
P
I
V
P
E
-----------------------
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
Q
-
E
-----
N
-----------------------------
D
S
R
K
R
S
-----
R
Q
R
L
A
V
A
I
I
L
L
A
-
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
--------------------------------------------------------------------------
K
Q
G
---------------
V
E
---
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
E
------
T
---------------------------------
F
K
E
------
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
------
L
T
L
K
----------
E
H
L
I
A
Y
R
L
Y
D
-----------
L
-------------
D
-----------
E
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
--------
W
----
R
----
L
P
N
D
I
P
-----
Y
R
L
L
C
D
P
S
G
F
---------------
Q
E
D
P
T
-----
E
I
K
K
T
V
A
--------------
6
PsiBlast_PDB
79.06
36%
-55
- C1 -
3WDH
1
?
A:
[88-632]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------
Q
V
G
A
-----------------------------------
V
M
R
T
K
A
F
---------
D
D
L
Y
A
Y
D
--
G
-
N
D--
L
G
A
T
Y
D
--
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
T
T
Y
V
M
T
R
E
K
K
G
--------------
L
W
T
Y
T
V
Y
---
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
-----
F
----------------
I
W
R
E
-
A
V
D
P
Y
A
K
S
----------
V
S
V
------------
N
-----------------------------
G
----
T
------------
Y
G
V
V
V
-----------
D
L
A
K
T
N
I
P
K
P
S
M
S
L
-----
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
--
Q
---
K
-
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
--
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
--------
E
G
V
D
E
--
L
--
Q
P
--------------------------------------------------------------
L
K
M
---------
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
D
-----------------------------------------------------
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
-
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
----
E
T
----
S
----
S
F
E
H
L
-
V
P
G
Y
Y
F
R
Y
E
R
-
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
-----
T
M
N
D
V
R
R
A
I
D
E
--
I
D
P
T
V
I
I
L
G
E
G
W
-----
D
L
A
T
P
--
L
P
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
-----
S
-
T
F
D
I
H
E
-----
R
G
F
A
L
G
----------------
D
-
C
-
S
Y--------------
K
-
E
A
V
I
G
A
I
R
G
S
----
I
---
H
L
---------------------------
F
F
-
S
-----------------------
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
H
-
E
-----
S
-----------------------------
E
Y
I
R
R
K
-----
R
Q
K
L
A
T
A
I
V
L
L
S
-
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
------------------------------
K
---------------
G
--------------------------------------------
V
E
---
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
S
------
R
---------------------------------
W
E
E
------
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
-------
R
H
M
K
F
------
Y
D
T
H
----------
P
S
V
I
A
Y
Q
L
V
D
-----------
V
-------------
G
-----------
V
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
--------
L
----
P
----
L
A
D
G
K
W
-----
K
V
M
F
S
S
E
L
G
N
---------------
V
C
E
Q
F
-----
I
E
I
N
G
I
G
--------------
7
PsiBlast_PDB
78.19
27%
-49
- C1 -
2YA1
7
?
A:
[292-927]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-----------------------------------
P
Y
T
V
-----------------------------------
S
Y
N
S
D
Q
F
T
T
K
T
S
W
R
L
K
D
E
T
Y
S
Y
D
--
G
-
K
---
L
G
A
D
L
K
--
E
EG
K
--
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
K
V
V
G
T
V
-
A
L
E
K
G
E
R
G
T
W
K
Q
T
L
D
S
T
N
K
L
G
I
T
D
F
T
---
G
-------
Y
-----
Y
----
Y
Q
Y
Q
I
E
R
Q
-----
G
------
K
---------
T
V
-
L
-
A
L
D
P
Y
A
K
S
----------
L
A
A
WNSDDSKIDDAH
K
-----------------------------
V
----
A
------------
K
A
A
F
V
--
D
P
A
K
--
L
G
P
Q
--
D
L
T
Y
G
K
I
H
N
F
K
-----
T
----
R
E
--
D
A
V
I
Y
E
A
H
V
R
D
F
T
-
S
D
P
A
I
A
K
DL
T
K
P
-
F
-
G
T
F
E
A
F
I
E
K
-------------
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
YFVNELKN
H
E
R
L
S
--
D
YA
S
S
--------------------------------------------------------------
N
S
N
---------
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
K
-----------------------------------------------------
N
P
E
K
R
I
A
E
F
K
N
L
I
N
E
I
H
-
K
R
-
G
M
G
A
I
L
D
V
V
Y
N
H
T
--
A
----
K
V
----
D
----
L
F
E
D
L
-
E
P
N
Y
Y
H
F
M
D
A
-
D
-
G
T
P
R
T
S
F
G
G
G
-
R
L
G
T
T
H
H
M
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
S
I
E
E
A
Y
K
A
A
R
A
--
L
N
P
N
L
I
M
L
G
E
G
W
-----
R
T
Y
A
G
DE
N
M
P
T
--
K
A
A
D
Q
D
W
M
K
H
T
D
T
V
A
V
F
S
D
D
I
R
N
N
L
K
S
-----
G
-
Y
P
N
E
G
Q
-----
P
A
F
I
T
G
----------------
G
-
K
-
R
---------------
D
V
N
T
I
F
K
N
L
I
A
Q
----
P
---
T
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
I
I
A
Q
S
---
I
K
K
-
D
-----
P
-----------------------------
S
K
A
E
N
Y
A
E
I
H
R
R
L
R
L
G
N
L
M
V
L
T
A
-
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
Q
F
RNPAYRT
P
V
A
E
DKVPN-------
K
---------------
S
-
H
L
-------------------
L
R
-
D
K
D
G
NPFDYPYF-------
I
H
---
D
S
Y
D
S
S
D
A
V
N
K
F
D
W
T
K
A
T
------
D
---------------------------------
G
K
A
Y
P
E
N
V
K
S
R
D
Y
M
K
G
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
-------
D
R
V
H
L
------
I
T
V
P
----------
G
Q
N
G
V
E
K
E
D
V
-----------
V
-------------
I
-----------
G
Y
Q
I
T
A
P
N
G
D
I
Y
A
V
F
V
N
A
D
E
--------
K
----
A
----
R
E
F
N
L
G
-----
T
A
F
A
H
L
R
N
A
E
---------------
V
L
A
D
E
-----
N
Q
A
G
P
V
G
--------------
8
PsiBlast_PDB
76.58
29%
-53
- C1 -
3FAW
9
?
A:
[126-719]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
Y
A
Y
S
--
G
-
N
---
L
G
A
V
L
N
--
Q
DG
S
--
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
L
V
K
------------
N
N
K
G
V
W
Q
T
I
L
D
TKL
G
-------
I
-----
K
N
Y
T
G
Y
Y
Y
L
Y
E
I
K
-----
R
------
G
---------
K
D
K
V
K
I
L
D
P
Y
A
K
S
LAEWDS----
N
T
V
------------
N
-----------------------------
D
DIK
T
A
------------
K
A
A
F
V
--
N
P
S
Q
--
L
G
P
Q
N
L
S
F
A
K
I
A
N
F
K
G
R
-----
Q
----
D
----
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
D
G
K
--
L
K
N
-
Q
L
G
T
F
A
A
F
S
E
K
-------------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
--------
F
Y
V
N
E
--
M
--
D
K
--------------------------------------------------------------
S
R
S
TAYTSSDNN
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
-
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
T
----
Y
----------
L
F
E
D
I
-
E
P
N
Y
Y
H
F
M
N
E
-
D
-
G
S
P
R
E
S
F
G
-
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
A
I
E
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
P
--
V
K
P
-----
A
D
Q
D
W
M
K
S
T
D
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
-----
G
F
P
N
E
G
T
P
-----
A
F
I
T
G
G
----------------
P
-
Q
-
S
---------------
L
-
Q
G
I
F
K
N
I
K
A
Q
----
P
---
G
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
I
NK
D
P
K
-
V
-----
A
-----------------------------
E
E
D
I
H
R
-----
R
L
R
L
G
N
V
M
I
L
T
S
-
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
R
L
-------
L
N
P
D
YMTKVSDDKLPN
K
---------------
A
-
T
L
-------------------
I
E
A
V
K
E
Y
---------------
P
Y
FIH
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
T
DNNKH
P
I
---------------------------------
S
T
K
------
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
------
I
T
E
V
----------
G
Q
G
D
I
K
E
K
D
L
-----------
V
-------------
I
-----------
A
Y
Q
T
I
D
S
K
G
D
I
Y
A
V
F
V
N
A
D
S
--------
K
----
A
----
R
N
V
L
L
G
-----
E
K
Y
K
H
L
L
K
G
Q
---------------
V
I
V
D
A
-----
D
Q
A
G
I
K
P
--------------
40
HHSearch
76.50
26%
-56
- C1 -
2VR5
5
?
A:
[6-688]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
R
D
R
---------
P
L
R
P
G
D
P
--
Y
-
P
---
L
G
S
N
W
I
ED
D
--
D
--
G
V
N
F
S
L
F
S
E
N
A
E
K
V
E
L
L
L
Y
S
L
T
N
Q
K
Y
-
P
K
E
I
I
E
V
K
N
K
-----------
T
G
D
I
W
H
V
F
V
P
---
G
-------
L
-----
R
P
G
Q
L
Y
A
Y
R
V
Y
G
P
-----
Y
------
K
PELG
L
R
F
N
P
N
K
V
--
L
I
D
P
Y
A
K
A
----------
I
N
G
------------
S
VIWNDAVFGYKIGDQNQDLTYDERDSGEY
V
----
P
------------
K
S
V
V
I
--
N
P
------
Y
F
E
W
D
D
E
D
F
I
K
-
G
K
K
-----
V
-----
P
L
K
D
T
V
I
Y
E
V
H
V
K
G
F
T
K
L
R
L
D
L
P
---
E
N
I
-
R
-
G
T
Y
E
G
L
-----------
A
S
E
Q
M
I
S
Y
L
K
D
L
G
I
T
T
V
E
L
M
P
V
F
H
---------
F
--------
I
-
D
Q
R
F
L
T
--
D
K
--------------------------------------------------------------
G
L
T
---------
N
Y
W
G
Y
D
P
I
N
F
F
S
P
E
C
R
Y
S
S
T
G
C
-----------------------------------------------------
L
G
G
-
Q
V
L
S
F
K
K
M
V
N
E
L
H
-
N
A
-
G
I
E
V
I
I
D
V
V
Y
N
H
T
A
E
G
----
N
H
----
L
G
P
T
L
S
F
R
G
I
D
N
T
A
Y
Y
M
L
Q
P
D
N
K
-
R
Y
Y
L
D
F
T
G
T
G
N
T
L
N
L
S
H
P
R
V
I
Q
M
V
L
D
S
L
R
Y
W
V
T
E
M
H
V
D
G
F
R
F
D
L
A
A
A
L
A
R
E
LYSVN
M
L
N
T
F
F
I
A
L
Q
Q
D
P
I
L
S
Q
V
K
L
I
A
E
P
W
-----
D
V
G
Q
G
--
G
Y
Q
----
V
G
N
F
P
-----
Y
Q
W
A
E
W
N
G
K
Y
R
D
S
I
R
------
R
--------------
F
W
R
G
----------------
E
-
A
L
P
---------------
Y
-
S
E
I
A
N
R
L
L
G
S
----
P
---
D
I
-----------------------
Y
LG
N
N
K
-
T
-----------------------
P
F
A
S
I
N
Y
V
T
S
H
D
G
F
T
L
E
D
L
V
S
Y
N
---
Q
K
H
-
N
-----
E
ANGFNNQDGMNENYSWNCGAEGPTND
Q
N
V
V
I
C
R
E
K
-----
Q
K
R
N
F
M
I
T
L
L
V
S
-
Q
G
T
P
M
I
L
G
G
D
E
L
S
R
T
Q
-----
R
G
------------------------------------------------------------------------------------
N
N
---
N
A
F
C
Q
D
N
E
I
T
W
F
D
W
N
L
D
E
------
R
---------------------------------
K
S
K
------
F
L
E
F
V
K
K
M
I
Q
F
Y
R
A
H
P
A
F
R
R
E
R
Y
F
Q
G
K
KLFGMPL
K
D
V
T
F
------
Y
T
L
E
GREVD
E
K
T
W
S
S
P
T
Q
L
V
I
F
V
L
-----------
E
GSVMDEINMYG
E
R
I
A
----------
D
D
S
F
L
I
I
L
N
A
N
P
N
N
V
K
V
K
F
P
--------
K
G
K
W
-
E
----
L
V
I
S
S
Y
-----
L
R
E
I
K
P
E
E
R
I
---------------
I
E
G
E
K
-----
E
L
E
I
E
G
R
--------------
9
PsiBlast_PDB
76.25
29%
-54
- C1 -
3FAX
6
?
A:
[126-719]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
Y
A
Y
S
--
G
-
N
---
L
G
A
V
L
N
--
Q
DG
S
--
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
L
V
K
------------
N
N
K
G
V
W
Q
T
I
L
D
TKL
G
-------
I
-----
K
N
Y
T
G
Y
Y
Y
L
Y
E
I
K
-----
R
------
G
----------
D
K
V
K
I
L
D
P
Y
A
K
S
LAEWDS----
N
T
V
------------
N
-----------------------------
D
DIK
T
A
------------
K
A
A
F
V
--
N
P
S
Q
--
L
G
P
Q
N
L
S
F
A
K
I
A
N
F
K
G
R
-----
Q
----
D
----
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
D
G
----
K
N
-
Q
L
G
T
F
A
A
F
S
E
K
-------------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
--------
F
Y
V
N
E
--
M
--
D
K
--------------------------------------------------------------
S
R
S
TAYTSSDNN
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
-
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
T
----
Y
----------
L
F
E
D
I
-
E
P
N
Y
Y
H
F
M
N
E
-
D
-
G
S
P
R
E
S
F
G
-
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
-----
A
I
E
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
RTFQG
D
Q
G
K
P
--
V
K
P
-----
A
D
Q
D
W
M
K
S
T
D
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
-----
G
F
P
N
E
G
T
P
-----
A
F
I
T
G
G
----------------
P
-
Q
-
S
---------------
L
-
Q
G
I
F
K
N
I
K
A
Q
----
P
---
G
N
-----------------------
F
--
E
A
D
-
S
-----------------------
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
I
NK
D
P
K
-
V
-----
A
-----------------------------
E
E
D
I
H
R
-----
R
L
R
L
G
N
V
M
I
L
T
S
-
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
-----
R
L
-------
L
N
P
D
YMTKVSDKLPN-
K
---------------
A
-
T
L
-------------------
I
E
A
V
K
E
Y
---------------
P
Y
FIH
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
T
DNNKH
P
I
---------------------------------
S
T
K
------
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
------
I
T
E
V
----------
G
Q
G
D
I
K
E
K
D
L
-----------
V
-------------
I
-----------
A
Y
Q
T
I
D
S
G
D
I
Y
A
V
F
V
N
A
D
S
K
--------
A
----
R
----
N
V
L
L
G
E
-----
K
Y
K
H
L
L
K
G
Q
V
---------------
I
V
D
A
D
-----
Q
A
G
I
K
P
I
--------------