@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0896: (2015-12-04 )
MSETKVMALREAINVAMSEEMRKDEKVFLMGEDVGVYGGDFGTSVGMLEEFGAKRVRDTPISEAAIAGSAIGAAQTGLRPIVDLTFMDFVTIAMDAIVNQGAKTNYMFGGGLSTPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGLKVVAPGTVNESKALLKSSILDNNPVIFLEPKALYGKKEEVNMDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVMQAAEEVAEEGINVEVVDPRTLIPLDKELIIDSVKKTGKLILVNDAYKTGGFTGEIATMVAESEAFDYLDHPIVRLASEDVPVPYSRVLEQGILPDVAKIKDAIYKVVNKGK
Atome Classification :
(20 SA)
.........10........20........30........40........50-........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...-.---...190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSE
T
K
V
M
A
L
R
E
A
I
N
V
A
M
S
E
E
MRKD
E
K
V
F
L
M
GEDVGVYGGDFGTS
V
G
M
L
E
E
F-GAKRVRDTPIS
E
A
AIAGSA
I
G
A
A
QTGLR
P
I
V
D
L
T
F
M
D
F
V
T
I
A
M
D
A
I
V
NQGAKT
N
Y
M
FGGGLST
P
V
T
F
R
VASGSGIG
S
A
A
Q
H
S
Q
S
L
E
A
W
L
T
HIPG
L
K
V
VAPGTV
N
E
S
K
A
L
L
K
S
SILDNN
P
V
I
F
LE
P
K
A
LYGKKEE-V---NMDP
D
F
Y
I
PLGKGDIKREGT
D
L
T
I
V
S
Y
G
R
M
L
E
R
V
M
Q
A
A
E
E
V
A
E
EGI
N
V
E
VVDPRTLIPL
D
K
E
L
I
I
D
S
V
K
KTG
K
L
I
L
V
NDAYKTGGFT
G
E
I
A
T
M
V
AE
S
E
A
F
D
Y
L
D
H
P
I
V
R
LASEDVPV
P
Y
S
R
V
L
E
QGILP
D
V
A
K
I
K
D
A
I
Y
K
V
V
NKGK
2
PsiBlast_PDB
92.95
44%
-78
- C4 -
3EXE
3
ODPB_HUMAN
B:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
41
PsiBlast_CBE
91.98
44%
-79
- C4 -
3EXE
3
ODPB_HUMAN
F:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
42
PsiBlast_CBE
91.69
44%
-77
- C4 -
3EXE
3
ODPB_HUMAN
D:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
22
PsiBlast_CBE
91.48
44%
-79
- C4 -
3EXH
3
ODPB_HUMAN
H:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
40
PsiBlast_CBE
91.30
44%
-77
- C4 -
3EXE
3
ODPB_HUMAN
H:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
5
PsiBlast_PDB
90.82
44%
-77
- C4 -
3EXH
4
ODPB_HUMAN
B:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
37
PsiBlast_CBE
90.76
44%
-83
- C4 -
3EXF
2
ODPB_HUMAN
H:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
6
PsiBlast_PDB
90.58
44%
-80
- C4 -
3EXI
2
ODPB_HUMAN
B:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
21
PsiBlast_CBE
90.57
44%
-78
- C4 -
2OZL
2
ODPB_HUMAN
D:
[15-340]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
23
PsiBlast_CBE
90.56
44%
-76
- C4 -
3EXH
2
ODPB_HUMAN
F:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
24
PsiBlast_CBE
90.47
44%
-79
- C4 -
3EXH
4
ODPB_HUMAN
D:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
38
PsiBlast_CBE
90.37
44%
-78
- C4 -
3EXF
2
ODPB_HUMAN
F:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
39
PsiBlast_CBE
90.24
44%
-81
- C4 -
3EXF
2
ODPB_HUMAN
D:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
1
PsiBlast_PDB
90.05
44%
-78
- C4 -
2OZL
2
ODPB_HUMAN
B:
[15-340]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
3
PsiBlast_PDB
89.75
44%
-78
- C4 -
3EXF
2
ODPB_HUMAN
B:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
P
PE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
7
PsiBlast_PDB
89.41
43%
-77
- C4 -
1NI4
2
ODPB_HUMAN
B:
[15-340]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
25
PsiBlast_CBE
89.30
44%
-77
- C4 -
3EXG
22
ODPB_HUMAN
Z:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
4
PsiBlast_PDB
88.94
44%
-76
- C4 -
3EXG
-
ODPB_HUMAN
B:
[3-328]
------
V
T
V
R
D
A
I
N
Q
G
M
D
E
E
L
E
R
D
E
K
V
F
L
L
G
E
E
V
A
Q
Y
D
G
A
Y
K
V
S
R
G
L
W
K
K
Y
-
G
D
K
R
I
I
D
T
P
I
S
E
M
G
F
A
G
I
A
V
G
A
A
M
A
G
L
R
P
I
C
E
F
M
T
F
N
F
S
M
Q
A
I
D
Q
V
I
N
S
A
A
K
T
Y
Y
M
S
G
G
L
Q
P
V
P
I
V
F
R
G
P
N
G
A
S
A
G
V
A
A
Q
H
S
Q
C
F
A
A
W
Y
G
H
C
P
G
L
K
V
V
S
P
W
N
S
E
D
A
K
G
L
I
K
S
A
I
R
D
N
N
P
V
V
V
L
E
N
E
L
M
Y
G
V
P
F
E
-
F
PPE
A
Q
S
K
D
F
L
I
P
I
G
K
A
K
I
E
R
Q
G
T
H
I
T
V
V
S
H
S
R
P
V
G
H
C
L
E
A
A
A
V
L
S
K
E
G
V
E
C
E
V
I
N
M
R
T
I
R
P
M
D
M
E
T
I
E
A
S
V
M
K
T
N
H
L
V
T
V
E
G
G
W
P
Q
F
G
V
G
A
E
I
C
A
R
I
M
E
G
P
A
F
N
F
L
D
A
P
A
V
R
V
T
G
A
D
V
P
M
P
Y
A
K
I
L
E
D
N
S
I
P
Q
V
K
D
I
I
F
A
I
K
K
T
L
N
I
--
8
PsiBlast_PDB
88.90
42%
-75
- C4 -
1UM9
-
ODBB_THET8
B:
[3-323]
-----
L
M
T
M
V
Q
A
L
N
R
A
L
D
E
E
M
A
K
D
P
R
V
V
V
L
G
E
D
V
G
K
R
G
G
V
F
L
V
T
E
G
L
L
Q
K
Y
-
G
P
D
R
V
M
D
T
P
L
S
E
A
A
I
V
G
A
A
L
G
M
A
A
H
G
L
R
P
V
A
E
I
Q
F
A
D
Y
I
F
P
G
F
D
Q
L
V
S
Q
V
A
K
L
R
Y
R
S
G
G
Q
F
T
A
P
L
V
V
R
M
P
S
G
G
G
V
R
G
G
H
H
H
S
Q
S
P
E
A
H
F
V
H
T
A
G
L
K
V
V
A
V
S
T
P
Y
D
A
K
G
L
L
K
A
A
I
R
D
E
D
P
V
V
F
L
E
P
K
R
L
Y
R
S
V
K
E
-
E
---
V
P
E
E
D
Y
T
L
P
I
G
K
A
A
L
R
R
E
G
K
D
L
T
L
I
C
Y
G
T
V
M
P
E
V
L
Q
A
A
A
E
L
A
K
A
G
V
S
A
E
V
L
D
L
R
T
L
M
P
W
D
Y
E
A
V
M
N
S
V
A
K
T
G
R
V
V
L
V
S
D
A
P
R
H
A
S
F
V
S
E
V
A
A
T
I
A
E
-
D
L
L
D
M
L
L
A
P
P
I
R
V
T
G
F
D
T
P
Y
P
Y
A
Q
--
D
K
L
Y
L
P
T
V
T
R
I
L
N
A
A
K
R
A
L
D
Y
--
95
HHSearch
88.89
42%
-83
- C4 -
1W85
3
ODPB_GEOSE
B:
[2-323]
-----
Q
M
T
M
V
Q
A
I
T
D
A
L
R
I
E
L
K
N
D
P
N
V
L
I
F
G
E
D
V
G
V
N
G
G
V
F
R
A
T
E
G
L
Q
A
E
F
G
E
-
D
R
V
F
D
T
P
L
A
E
S
G
I
G
G
L
A
I
G
L
A
L
Q
G
F
R
P
V
P
E
I
Q
F
F
G
F
V
Y
E
V
M
D
S
I
C
G
Q
M
A
R
I
R
Y
R
T
G
G
R
Y
H
M
P
I
T
I
R
S
P
F
G
G
G
V
H
T
P
E
L
H
S
D
S
L
E
G
L
V
A
Q
Q
P
G
L
K
V
V
I
P
S
T
P
Y
D
A
K
G
L
L
I
S
A
I
R
D
N
D
P
V
I
F
L
E
H
L
K
L
Y
R
S
F
R
Q
E
V
---
P
E
G
-
E
Y
T
I
P
I
G
K
A
D
I
K
R
E
G
K
D
I
T
I
I
A
Y
G
A
M
V
H
E
S
L
K
A
A
A
E
L
E
K
E
G
I
S
A
E
V
V
D
L
R
T
V
Q
P
L
D
I
E
T
I
I
G
S
V
E
K
T
G
R
A
I
V
V
Q
E
A
Q
R
Q
A
G
I
A
A
N
V
V
A
E
I
N
-
E
R
A
I
L
S
L
E
A
P
V
L
R
V
A
A
P
D
T
V
Y
P
F
A
Q
-
A
E
S
V
W
L
P
N
F
K
D
V
I
E
T
A
K
K
V
M
N
F
--