@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0917: (2015-12-04 )
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
Atome Classification :
(20 SA)
.........10........20........30...------.....40..---.----------------.....50........60..--......70........80........90........100.......110....--.-------..120.......130.-......140......-----------.---150.......------------------------------------------------------------------------------------------160--------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------.------------------------------------------------------------------------------------.--....------..170.....----------.-------------------------------------------------------------------------------------------------------------.180----------------------.........190-----..---------------------------.---------....200.......---210..---.-......220.......230...-....---------240.---......250.-.-.......260.......270.--...-...280......----.290--..-.....-.300.......310.......320.....---..330....--...340.......350.......360......-.370..-----.....380........-------------------390-------------...-----------.---------------------------------------.-------..--------------------..-------------------------------------400-------------.----------------.----------------------------------.---------------......410.......420.......430.......440...-....450.......460.......470..----.....480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
E
D
L
K
K
R
Q
E
K
IRN
F
S
I
I
A
H
IDHG
K
S
T
L
A
D
R
I
L
------
E
K
T
ETV
S
S
R
---
E
----------------
M
Q
A
Q
L
L
D
S
MDL
E
R
ER
G
I
T
I
--
K
L
N
A
I
E
L
N
Y
TAKDG
E
T
Y
I
F
H
L
IDTPG
H
V
D
F
T
Y
E
V
S
R
S
L
A
ACE
G
A
I
L
V
V
DAAQG--I-------
E
A
Q
T
L
A
N
V
Y
L
A
LDNDL-
E
I
L
P
V
I
NKIDLPAA
D
-----------
P
---
E
R
V
R
A
E
V
E
D
V
------------------------------------------------------------------------------------------I----------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------------L------------------------------------------------------------------------------------D--
A
S
E
A
------
V
L
A
S
AKAGI
G
----------
I
-------------------------------------------------------------------------------------------------------------
E
E
------------------------
I
L
E
Q
I
V
E
KVPAP-----TG---------------------------E---------VD
A
P
L
Q
A
L
I
F
D
S
V
Y
---
D
--
A
Y
---R-
G
V
I
L
Q
V
R
I
VNGMVKPG
D
K
I
Q
M
M-SNGK---------
T
F
D
V
---
T
E
VGIF
T
--
P
-
K
-AVGRDFLATGD
V
G
Y
I
A
A
S
I
K
T
--VAD-TRVG
D
T
I
T
LANN----PAI---EP-
L
H
G
Y
K-QMN
P
M
V
F
A
G
L
YPIESN
K
Y
N
D
L
R
E
A
L
E
K
LQ---LNDA
S
L
Q
FE--PETS
Q
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
D
V
I
Q
E
R
L
E
R
EF-NI
D
L
I
M
-----TAP
S
V
V
-
Y
H
V
NTTDG
E
-------------------
M
---------------
L
EV-----------S---------------------------------------N-------PS--------------------EF-------------------------------------P---------------D----------------P----------------------------------T---------------RVDSIEEPY
V
K
A
Q
I
MV
P
Q
E
F
V
G
A
V
M
E
L
A
Q
RKRG
D
F
V
T
M
D
Y
ID-DN
R
V
N
V
I
Y
QI
P
L
A
E
I
V
F
D
F
F
D
K
L
K
SSTRG----
Y
A
S
F
DY
E
I
S
E
Y
R
R
S
Q
L
V
K
M
D
I
L
LNGDK
V
D
A
L
S
F
I
V
H
K
E
F
A
Y
E
R
G
K
L
I
V
D
K
L
K
K
II
P
R
Q
QFEV
P
I
Q
A
AIG
Q
K
I
V
A
R
S
D
I
K
A
L
R
K
N
V
L
A
K
CYGG
D
V
S
R
K
R
K
L
L
E
K
Q
K
A
G
K
K
R
M
K
A
IGSVEV
P
Q
E
A
F
L
S
V
LSMDDDDKK
102
Fugue
96.68
55%
-125
- C2 -
3CB4
-
LEPA_ECOLI
A:
[1-555]
---------
M
K
N
I
R
N
F
S
I
I
A
H
I
----
S
T
L
S
D
R
I
I
------
Q
I
C
G
G
-----------------------------------------------
Q
S
V
T
L
D
Y
K
A
S
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
--
V
-------
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
-
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
---
E
R
V
A
E
E
I
E
D
I
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
D
--
A
T
D
A
------
V
R
C
S
A
K
T
G
V
G
----------
V
-------------------------------------------------------------------------------------------------------------
Q
D
------------------------
V
L
E
R
L
V
R
D
I
P
P
P
-----
E
G
---------------------------
D
---------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
---
D
--
N
Y
---
L
-
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
-
S
T
G
Q
---------
T
Y
N
A
---
D
R
L
G
I
F
T
--
P
-
K
-
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
D
--
I
H
G
-
A
P
V
G
D
T
L
T
L
A
R
N
----
P
A
E
---
K
A
-
L
P
G
F
K
-
K
V
K
P
Q
V
Y
A
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
E
--
P
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
-
D
L
D
L
I
T
-----
T
A
P
T
V
V
-
Y
E
V
E
T
T
S
R
E
-------------------
V
---------------
I
Y
V
-----------
D
---------------------------------------
S
-------
P
S
--------------------
K
L
-------------------------------------
P
---------------
A
----------------
V
----------------------------------
N
---------------
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
V
Q
T
N
M
V
Y
H
G
--
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
----
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D
A
L
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
R
K
N
V
L
A
K
C
Y
G
---------------------------------------------
1
PsiBlast_PDB
89.35
56%
-108
- C3 -
3DEG
1
LEPA_ECOLI
C:
[2-545]
----------
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
------
Q
I
C
G
G
L
S
D
R
---
E
----------------
M
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
--
K
A
Q
S
V
T
L
D
Y
K
A
S
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
--
V
-------
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
-
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
---
E
R
V
A
E
E
I
E
D
I
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
D
--
A
T
D
A
------
V
R
C
S
A
K
T
G
V
G
----------
V
-------------------------------------------------------------------------------------------------------------
Q
D
------------------------
V
L
E
R
L
V
R
D
I
P
P
P
-----
E
G
---------------------------
D
---------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
---
D
--
N
Y
---
L
-
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
-
S
T
G
Q
---------
T
Y
N
A
---
D
R
L
G
I
F
T
--
P
-
K
-
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
D
--
I
H
G
-
A
P
V
G
D
T
L
T
L
A
R
N
----
P
A
E
---
K
A
-
L
P
G
F
K
-
K
V
K
P
Q
V
Y
A
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
E
--
P
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
-
D
L
D
L
I
T
-----
T
A
P
T
V
V
-
Y
E
V
E
T
T
S
R
E
-------------------
V
---------------
I
Y
V
-----------
D
---------------------------------------
S
-------
P
S
--------------------
K
L
-------------------------------------
P
---------------
A
----------------
V
----------------------------------
N
---------------
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
V
Q
T
N
M
V
Y
-
H
-
G
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
----
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D
A
L
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
-------------------------------------------------------
75
HHSearch
73.51
29%
-96
- C1 -
2XEX
2
EFG_STAAU
A:
[5-678]
-------
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
------
Y
Y
T
G
R
I
H
-------------------------------------------
T
S
A
A
T
T
A
A
W
E
-----
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
--
V
-------
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
-
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
-----------
F
---
E
Y
S
V
S
T
L
H
D
R
------------------------------------------------------------------------------------------
L
QANAAPI
Q
L
P
I
G
AEDEFEAIIDLVEM
K
C
F
K
Y
TNDLGTE
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
-------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------
E
--
F
Y
P
V
------
L
C
G
T
A
F
K
N
K
G
----------
V
-------------------------------------------------------------------------------------------------------------
Q
L
------------------------
M
L
D
A
V
I
D
Y
L
P
S
P
-----
L
D
V
K
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
A-------
D
---------
D
S
A
E
F
A
A
L
A
F
K
V
M
T
---
D
--
P
Y
---
V
-
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
-
T
K
G
K
---------
R
E
R
V
---
G
R
L
L
Q
M
H
--
A
-
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
-
G
-----
L
K
D
-
T
G
T
G
D
T
L
C
G
E
K
N
------
D
---
I
I
-
L
E
S
M
E
-
F
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
---
E
E
D
P
T
F
H
A
H
T---
T
G
Q
-----
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
-
N
V
E
C
N
V
-----
G
A
P
M
V
S
-
Y
R
E
T
F
K
S
S
A
Q
V
Q
G
K
F
S
R
QSGG
R
G
Q
Y
G
D
V
H
---------------
I
E
F
-----------
T
P
N
E
TGA
G
F
E
F
E
----------------------------
N
AIVGGVV
P
R
EY
I
P
S
V
E
A
G
L
K
D
A
M
E
N
GVLA
G
Y
-------------------------------------
P
---------------
L
----------------
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DVDSS
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
---------------
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
--
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
L
R
S
N
T
Q
G
----
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
E
-----------------------------------------------------------------------------------------------------------
80
HHSearch
60.64
22%
-80
- C1 -
3JB9
-
?
B:
[132-930]
---
F
G
L
L
T
G
T
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
------
Y
Y
T
H
P
D
T
K
P
PK-
R
----------------
R
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
--
K
S
T
P
L
T
L
A
V
S
D
M
K
G
K
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
--
V
-------
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
M
-
P
I
V
L
V
L
N
K
V
D
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
---
R
H
V
I
D
E
V
N
D
N
------------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------
C
Q
I
SKDLK
Y
R
----------------------------------------------------------------------------
V
------------------------------------------------------------------------------------
S
PE
L
G
N
V
------
C
F
A
S
C
D
L
G
Y
C
----------
F
T
L
S
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
LWGD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
F
QIYLK
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
S
F
FGFP
V
G
------------------------
F
V
N
A
V
T
R
H
I
P
S
P
-----
R
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
---------
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
---
T
--
V
D
---
A
N
N
F
Y
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
K
V
L
-
G
E
N
Y
SLEDEED
M
V
V
A
H
I
---
A
E
I
C
V
P
C
--
A
-
R
Y
R
L
H
V
D
G
A
V
A
G
M
L
V
L
L
G
-
G
V
-----
D
N
S
I
S
K
T
A
T
I
V
S
D
N
L
K---
D
D
P
---
Y
I
-
F
R
P
I
A
H
M
S
E
S
V
F
K
V
A
V
E
P
H
N
P
S
E
L
P
K
L
L
D
G
L
R
K
T
N
---
K
S
Y
P
L
S
I
T
K
V
-
E
E
S
G
E
H
T
I
F
G
-----
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
Y
S
E
I
E
I
R
V
-----
S
D
P
V
A
R
-
F
C
E
T
A
V
D
T
S
-------------------
S
I
K
C
F
S
D
T
PNKK
N
R
I
T
M
V
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDR
G
-------
T
N
--------------------
I
L
R
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
Q
G
F
Q
W
G
T
REGPLCD
E
T
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRG-----------
G
G---------------------------------
Q
I
I
P
T
A
R
R
V
C
Y
S
S
F
L
T
A
S
P
R
L
M
E
P
V
Y
M
V
E
V
H
A
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
H
V
L
Q
D
I
P
R
P
G
S
P
L
Y
L
V
R
A
L
I
P
V
I
D
S
-
C
G
F
E
T
D
L
R
V
H
T
Q
G
----
Q
A
M
C
Q
M
V
F
D
H
W
Q
V
---------
V
P
G
D
P
L
D
K
S
I
K
P
K
P
L
E
P
A
R
G
S
D
L
A
R
D
F
L
I
K
T
R
R
R
K
G
L
V
E
D
V
S
T
T
R
Y
F
D
Q
E
M
---------------------------------------------------------------
84
HHSearch
60.59
28%
-91
* C1 *
3VQT
1
RF3_DESVM
A:
[23-499]
----
R
L
E
R
E
A
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
------
L
F
G
G
A
I
Q
M
A
---
G
S
V
K
A
R-----------------------------
V
--
T
T
S
V
M
Q
F
P
Y
R
-----
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
--
V
-------
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
-
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
-----------
P
---
L
D
V
M
A
D
I
E
Q
H
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------
I
E
C
A
P
M
T
W
P
I
G
MGSSFK
G
T
Y
D
LLHK
Q
L
H
L
F
SQ
S
G
I
V
I
H
G
ADDP
Q
L
D
E
Y
LGDQ
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
FD
E
E
R
Y
L
K
G-------
E
--
L
T
P
V
------
F
F
G
S
A
I
N
N
F
G
----------
V
-------------------------------------------------------------------------------------------------------------
R
E
------------------------
M
L
D
M
F
V
E
F
A
P
G
P
-----
Q
P
---------------------------
R
P
A
AT
R
V
V
E
P
G
E
E
A
F
T
G
V
V
F
K
I
Q
A
---
N
----------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
-
R
T
G
K
---------
D
V
T
V
---
A
N
A
T
I
F
M
--
A
-
Q
D
R
T
G
V
E
E
A
F
P
G
D
I
I
G
I
P
----
N
--
H
G
T
-
I
K
I
G
D
T
F
T
E
S
K
E
------
V
---
L
K
-
F
V
G
I
P
-
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
L
Q
K
G
L
E
Q
L
A
---
E
E
G
A
V
Q
L
F
R
P
-
L
V
N
N
D
Y
I
-----
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
-
G
V
D
A
V
Y
E
G
V
ST
H
T
A
R
W
V
-
Y
C
E
D
K
K
I
F
A
-------------------
D
---------------
F
Q
D
-----------
Y
---------------------------------------
H
-------
R
G
--------------------
E
L
-------------------------------------
A
---------------
V
----------------
D
----------------------------------
A
---------------
E
G
A
L
A
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
60.20
26%
-77
- C1 -
2DY1
2
?
A:
[6-649]
---------
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
------
Y
K
T
G
A
K
E
R
R
G
R
V
E
----------------
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
--
R
T
G
V
A
P
L
L
F
R
-----
G
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
--
V
-------
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
-
P
R
M
V
V
V
T
K
L
D
K
G
G
D
Y
---------------
Y
A
L
L
E
D
L
R
S
T
LGPILPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
----------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------
L
--
L
Y
P
V
------
A
L
A
S
G
E
R
E
I
G
----------
V
-------------------------------------------------------------------------------------------------------------
L
P
------------------------
L
L
E
L
I
L
E
A
L
P
S
P
-----
T
E
R--------------------------
F
---------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
---
D
--
P
F
---
M
-
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
-
A
G
-----------
Q
V
R
L
---
P
H
L
Y
V
P
M
--
G
-
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
P
----
K
--
A
E
G
-
L
H
R
G
M
V
L
W
Q
G
E
K
----
P
E
S
---
E
E
-
V
P
F
A
R
-
L
P
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
---
E
E
D
P
S
L
K
L
E
RQ
E
E
T
G
E
L
L
L
W
G
-----
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
-
G
V
E
V
E
F
-----
S
V
P
K
V
P
-
Y
R
E
T
I
K
K
V
A
E
G
Q
G
K
Y
K
K
Q
T
GG
H
G
Q
Y
G
D
V
W
---------------
L
R
L
-----------
E
P
A
S
E
Y
G
F
E
W
RITGGVIPSKY
Q
E
A
I
E
E
G
I
K
E
A
A
KK-----
G
-------
V
L
A-------------------
G
F
-------------------------------------
P
---------------
V
MG
F
K
A
I
VY
N
G
S
Y
H
EVD
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
----------------
E
---------------
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
--
A
L
S
V
V
H
A
E
V
P
L
A
E
V
-
L
E
Y
Y
K
A
L
P
G
L
T
G
G
----
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
G
----------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
57.02
31%
-92
- C3 -
4ZCI
1
?
B:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDFPI
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
KVG
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
VEAL
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
KEL
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
TGLL
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
83
HHSearch
56.09
25%
-87
- C1 -
2H5E
1
RF3_ECOLI
A:
[3-476]
--
L
S
P
Y
L
Q
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
------
L
F
G
Q
-------------------------------------------
I
--
T
T
S
V
M
Q
F
P
Y
H
-----
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
--
V
-------
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
-
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
-----------
P
---
M
E
L
L
D
E
V
E
N
E
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
K
I
G
C
A
P
I
T
W
P
I
G
CGKLFK
G
V
Y
H
LYKD
E
T
Y
L
Y
Q
S
GKGHTIQE
V
R
I
V
K
G
LNN
P
D
L
D
A
A
VG
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
G
ASNEFD
K
E
L
F
L
A
G
------------------------------------------------------------------------------------
E
--
I
T
P
V
------
F
F
G
T
A
L
G
N
F
G
----------
V
-------------------------------------------------------------------------------------------------------------
D
H
------------------------
M
L
D
G
L
V
E
W
A
P
A
P
-----
M
P
---------------------------
R
Q
T
DT
R
T
V
E
A
S
E
D
K
F
T
G
F
V
F
K
I
Q
A
N
MD
P
--
K
H
---
R
-
D
R
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
-
R
T
A
K
---------
D
V
V
I
---
S
D
A
L
T
F
M
--
A
------
V
E
E
A
Y
P
G
D
I
L
G
L
H
----
N
--
H
G
T
-
I
Q
I
G
D
T
F
T
Q
G
E
M
----------
M
K
-
F
T
G
I
P
-
N
F
A
P
E
L
F
R
R
I
R
L
K
D
P
---
K
Q
L
L
K
G
L
V
Q
L
S
---
E
E
G
A
V
Q
V
F
R
P
-
I
S
N
N
D
L
I
V
-----
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
-
N
V
E
A
V
Y
-----
E
S
V
N
V
A
-
T
A
R
W
V
E
C
A
D
-------------------
A
---------------
K
K
F
-----------
E
---------------------------------------
E
-------
F
K
--------------------
R
K
-------------------------------------
N
---------------
E
----------------
S
----------------------------------
Q
---------------
L
A
L
D
G
G
D
N
L
A
Y
I
A
T
S
M
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
54.83
25%
-79
- C1 -
3TR5
2
RF3_COXBU
A:
[6-513]
-----
V
E
K
Q
T
A
M
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
------
L
F
G
G
A
I
Q
L
A
---
G
T
I
K
S
R-------------
H
A
T
S
D
W
M
E
L
E
K
Q
R
G
I
S
V
--
T
T
S
V
M
Q
F
P
Y
K
-----
D
Y
L
I
N
L
L
D
T
P
G
H
A
D
F
T
E
D
T
Y
R
T
L
T
A
V
D
S
A
L
M
V
I
D
A
A
K
G
--
V
-------
E
P
R
T
I
K
L
M
E
V
C
R
L
R
H
T
-
P
I
M
T
F
I
N
K
M
D
R
D
T
R
P
-----------
S
---
I
E
L
L
D
E
I
E
S
I
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------
I
H
C
A
P
V
T
W
P
I
G
MGKYFK
G
I
Y
H
LIED
A
I
Y
L
Y
Q
P
GKHERVGE
S
E
R
I
E
G
INN
P
E
L
D
K
K
L
G
D
L
A
S
E
L
R
N
E
I
E
L
V
K
G
ASHPFE
R
E
G
Y
L
K
G
E
--
L
T
P
I
------
F
F
G
S
A
I
N
N
F
G
----------
V
-------------------------------------------------------------------------------------------------------------
G
E
------------------------
L
L
D
A
F
V
K
E
A
P
P
P
-----
Q
G
---------------------------
R
E
T
N
S
R
L
V
K
P
E
E
E
K
F
S
G
F
V
F
K
I
Q
A
---
N
MD
G
H
---
R
-
D
R
I
A
F
L
R
I
A
S
G
Q
Y
Q
K
G
M
K
A
Y
H
V
-
R
L
K
K
---------
E
I
Q
I
---
N
N
A
L
T
F
M
--
A
G
K
-
R
E
N
A
E
E
A
W
P
G
D
I
I
G
L
H
----
N
--
H
G
T
-
I
Q
I
G
D
T
F
T
Q
G
E
R
----------
F
K
-
F
T
G
I
P
-
N
F
A
S
E
L
F
R
L
V
R
L
K
D
P
L
K
Q
K
A
L
L
K
G
L
T
Q
L
S
---
E
E
G
A
T
Q
L
F
R
P
-
L
D
S
N
E
-----
L
I
L
G
A
V
G
L
L
Q
F
D
V
V
A
Y
R
L
E
N
E
Y
-
N
V
K
C
V
Y
-----
E
S
V
N
V
V
T
A
R
W
V
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
----
K
A
V
L
E
R
F
N
Q
E
--
Q
S
R
N
L
A
Y
D
---
G
G
G
H
L
T
Y
L
A
P
S
R
V
N
-
L
E
I
T
M
E
K
W
P
E
I
Q
F
----
S
E
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.54
31%
-93
- C3 -
4ZCL
2
?
A:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
Q
L
DF
P
I
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
VEAL
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
5
PsiBlast_PDB
54.52
31%
-91
- C3 -
4ZCI
1
?
A:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDF
P
I
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
V
E
A
L
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
22
PsiBlast_CBE
53.67
31%
-92
- C3 -
4ZCL
2
?
B:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDFPI
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
KVG
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
VEAL
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
KEL
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
TGLL
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
4
PsiBlast_PDB
53.66
31%
-91
* C3 *
4ZCM
3
?
A:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDF
P
I
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
V
E
A
L
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
21
PsiBlast_CBE
52.50
31%
-90
- C3 -
4ZCM
3
?
B:
[37-505]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
------------------------------------------
T
I
LA
K
N
T
A
I
K
W
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDFPI
V
Y
A
S
A
L
N
G
I
A
GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
KVG
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
G
--
L
G
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
VEAL
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
KEL
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
TGLL
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----------------
2
PsiBlast_PDB
48.04
31%
-82
- C3 -
5A9W
1
?
A:
[3-471]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
T
----------------------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
---
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F
-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDFPI
V
Y
A
S
A
L
N
---GLDHEDMAE
D
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
-----
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
V
E
A
L
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
P
-------
91
HHSearch
46.32
27%
-83
- C1 -
1F60
-
EF1A_YEAST
A:
[3-328]
--------
K
E
K
S
H
I
N
V
V
V
I
G
H
V
D
S
G
K
S
T
T
T
G
H
L
I
------
Y
K
C
G
G
I
D
K
R
---
T
I
E
K
F
E
K
E
A
AELGK
G
S
F
K
Y
A
W
V
L
D
K
L
K
A
E
R
E
R
G
I
T
I
--
D
I
A
L
W
K
F
E
T
P
-----
K
Y
Q
V
T
V
I
D
A
P
G
H
R
D
F
I
K
N
M
I
T
G
T
S
Q
A
D
C
A
I
L
I
I
A
G
G
V
G
--
E
F
E
A
G
I
SK
D
G
Q
T
R
E
H
A
L
L
A
F
T
L
G
V
R
Q
L
I
V
A
V
N
K
M
D
S
V
K
W
D
-----------
E
S
R
F
Q
E
I
V
K
E
T
S
N
F
------------------------------------------------------------------------------------------
I
K
K
V
-------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------
Y
NP----------------------------------------------------------------------------------
K
--
T
V
P
F
------
V
P
I
S
G
W
N
G
D
N
----------
M
-------------------------------------------------------------------------------------------------------------
I
E
ATTNAPWYK
G
W
E
K
E
T
KA
G
V
V
K
G
K
T
L
L
E
A
I
-
D
A
I
E
Q
P
-----
S
R
---------------------------
P
---------
T
D
K
P
L
R
L
P
L
Q
D
V
Y
K
---
I
--
G
G
---
I
-
G
T
V
P
V
G
R
V
E
T
G
V
I
K
P
G
M
V
V
T
F
A
-
P
A
G
V
---------
T
T
E
V
---
K
S
V
E
M
H
H
-------
E
Q
L
E
Q
G
V
P
G
D
N
V
G
F
N
V
K
N
V
S
--
V
K
E
-
I
R
R
G
N
V
C
G
D
A
K
N
----
D
P
P
---
K
G
-
C
A
S
F
N
-
A
T
V
I
V
L
N
H
P
G
Q
I
S
A
G
Y
S
P
V
L
D
C
H
T
A
H
I
A
C
---
R
F
D
E
L
L
E
K
N
--
D
R
R
S
G
K
K
L
E
D
H
P
K
F
L
K
S
G
D
A
A
L
V
K
F
V
P
S
K
P
M
C
-
V
E
A
F
S
E
-----
Y
P
P
L
G
R
-
F
A
V
R
D
M
R
Q
T
-------------------
V
---------------
A
V
G
-----------
V
---------------------------------------
I
-------
K
S
--------------------
V
D
-------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.80
31%
-84
- C3 -
5A9X
1
?
A:
[3-471]
----------
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
------
Q
Q
S
G
-------------------------------------
K
E
R
G
I
T
I
LA
K
N
T
A
-----------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
---
D
W
V
V
D
Q
V
F
D
L
F
-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
--
A
T
D
E
QLDFPI
V
Y
A
S
A
L
N
---GLDHEDMAED
M
-------------------------------------------------------------------------------------------------------------
T
P
------------------------
L
Y
Q
A
I
V
D
H
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
Y
---
V
-
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
---------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
--
L
-
E
-
R
I
E
T
D
L
A
E
A
G
D
I
----
V
A
I
T
-----
E
-
L
N
I
S
D
T
V
C
D
T
Q
N
V
E
A
L
P
A
L
SVD
E
P
T
V
S
M
F
F
-
C
V
N
T
S
P
F
C
G
----
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
---
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
--
E
I
D
G
R
-------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
----------------
99
HHSearch
45.50
21%
-93
- C1 -
3P26
-
HBS1_YEAST
A:
[158-496]
---
S
A
F
V
K
S
A
L
P
H
L
S
F
V
V
L
G
H
V
D
A
G
K
S
T
L
M
G
R
L
L
------
Y
D
L
N
I
V
N
Q
S
---
Q
L
R
K
L
QR------------------------
R
G
V
T
V
--
S
I
C
T
S
H
F
S
T
H
-----
R
A
N
F
T
I
V
D
A
P
G
H
R
D
F
V
P
N
A
I
M
G
I
S
Q
A
D
M
A
I
L
C
V
D
C
S
T
-FD
L
-------
D
G
Q
T
K
E
H
M
L
L
A
S
S
L
G
I
H
N
L
I
I
A
M
N
K
M
D
N
V
D
W
S
-----------
Q
Q
R
F
E
E
I
K
S
K
L
L
P
Y
L
V
D
---------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------
F
FE----------------------------------------------------------------------------------
D
--
N
I
N
W
------
V
P
I
S
G
F
S
G
E
G
----------
V
YK
I
E
Y
T
D
E
V
R
Q
W
YNG----------------------------------------------------------------------------------------------
P
N
------------------------
L
M
S
T
L
E
N
A
A
F
K
I
S
K
E
N
E
G
I
---------------------------
N
---------
K
D
D
P
F
L
F
S
V
L
E
I
I
P
--------TSN
D
-
L
A
L
V
S
G
K
L
E
S
G
S
I
Q
P
G
E
S
L
T
I
Y
-
P
S
E
Q
---------
S
C
I
V
---
D
K
I
Q
V
G
S
QQ----
H
E
E
T
D
V
A
I
K
G
D
F
V
T
L
K
--
L
R
K
AY
P
E
D
-
I
Q
N
G
D
L
A
A
S
V
D
Y
----
S
S
I
---
H
S
-
A
Q
C
F
V
-
L
E
L
T
T
F
D
M
N
R
P
L
L
P
G
T
P
F
I
L
F
I
G
V
K
E
Q
P
A
---
R
I
K
R
L
I
S
F
I
--
D
K
G
N
T
A
S
K
K
K
I
R
H
L
G
S
K
Q
R
A
F
V
E
I
E
L
I
E
V
K
R
W
-
I
P
L
L
T
A
-----
H
E
N
D
R
L
-
G
R
V
V
L
R
K
D
G
-------------------
R
---------------
T
I
A
-----------
A
---------------------------------------
G
-------
K
I
--------------------
S
E
-------------------------------------
I
---------------
T
----------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
45.17
31%
-116
- C3 -
3VQT
1
RF3_DESVM
B:
[33-185]
--------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
GA
I
Q
M
A
G
S
V
K
A
------------------------------------------
T
T
S
V
M
Q
F
P
Y
R
D
R
-----
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
--
V
-------
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
-
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
-----------
P
---
L
D
V
M
A
D
I
E
Q
H
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
E
--
C
A
P
M
------
T
W
P
I
G
M
G
S
S
F
----------
K
-------------------------------------------------------------------------------------------------------------
G
T
------------------------
Y
D
L
L
H
K
Q
L
H
L
F
I
-----
Q
S
---------------------------
G
---------
I
V
I
H
G
A
D
D
P
Q
L
D
E
Y
---
L
--
G
D
---
Q
-
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
F
D
E
E
R
-
Y
L
K
G
---------
E
L
T
P
---
V
F
F
G
S
A
I
--
N
-
N
-
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
Q
P
R
P
--
A
A
T
-
R
V
V
E
P
G
E
E
A
F
T
G
----
V
V
F
---
K
I
-
Q
A
R
M
A
-
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
---
T
I
F
M
A
Q
D
R
T
--
G
V
E
E
A
F
P
G
D
I
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
V
L
-
K
F
V
G
I
P
-----
N
F
A
P
E
H
-
F
R
R
V
R
L
K
N
P
-------------------
L
---------------
K
A
K
-----------
Q
---------------------------------------
L
-------
Q
K
--------------------
G
L
-------------------------------------
E
---------------
Q
----------------
L
----------------------------------
A
---------------
E
E
G
A
V
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
A
V
-
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
----
E
L
A
V
D
A
E
G
A
L
A
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
I
--------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
44.73
31%
-116
- C3 -
3VQT
1
RF3_DESVM
D:
[33-185]
--------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
GA
I
Q
M
A
G
------------------------------------------
S
V
--
T
T
S
V
M
Q
F
P
Y
R
D
R
-----
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
--
V
-------
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
-
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
-----------
P
---
L
D
V
M
A
D
I
E
Q
H
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
E
--
C
A
P
M
------
T
W
P
I
G
M
G
S
S
F
----------
K
-------------------------------------------------------------------------------------------------------------
G
T
------------------------
Y
D
L
L
H
K
Q
L
H
L
F
S
-----
R
I
---------------------------
Q
---------
S
G
I
V
I
H
G
A
D
D
P
Q
L
D
---
E
--
Y
L
---
G
-
D
Q
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
F
D
E
-
E
R
Y
L
---------
K
G
E
L
---
T
P
V
F
F
G
S
--
A
-
I
-
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
Q
P
--
R
P
A
-
A
T
R
V
V
E
P
G
E
E
A
F
----
T
G
V
---
V
F
-
K
I
Q
A
N
-
H
R
D
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
---
V
T
V
A
N
A
T
I
F
--
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
I
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
-
E
S
K
E
V
L
-----
K
F
V
G
I
P
-
N
F
A
P
E
H
F
R
R
-------------------
V
---------------
R
L
K
-----------
N
---------------------------------------
P
-------
L
K
--------------------
A
K
-------------------------------------
Q
---------------
L
----------------
Q
----------------------------------
K
---------------
G
L
E
Q
L
A
E
E
G
A
V
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
-
Y
G
V
D
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
----
Q
D
Y
H
R
G
E
L
A
V
D
A
E
G
A
L
A
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
I
--------------------------------------------------------------------------------------------