@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0953: (2015-12-04 )
MTDISILNDIQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITADEIRDINPIGIVLSGGPNSVYADGAFGIDEEIFELGIPILGICYGMQLITHKLGGKVLPAGEAGHREYGQSALRLRSESALFAGTPQEQLVLMSHGDAVTEIPEGFHLVGDSVDCPFAAMENTEKQFYGIQFHPEVRHSVYGNDILKNFAVNICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVVGVLLQRAIGDQLTCIFVDHGLLRKNEGDQVMDMLGGKFGLNIIRVDASKRFLDLLSGVEDPERKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTALGMPDEVVWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
Atome Classification :
(20 SA)
.........10----.--........20........30........40-........50........60........70....----....80----........90........100.......110------------------.......--------.120.---------------------------...-...130---...--------.-.--------.--------..---.140.......150.......-160.......170.......180.......190.......200.......210.......220.......230.......240.......250........260.......270.......--280.......-----------290...----------....300.......310.......---320..---.---.----...330.......340--....----.----...350.......360.--...--...370.......380.......390.......400.......410.......------------------------420.....----------------..430....--...440.....---------..450.......460.....---------------------------------------------------------------------------------------------------------..470.......480---........490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
D
I
S
I
L
N
D
I
-----
Q
--
K
I
I
VLDYG
S
Q
Y
N
Q
L
I
A
R
R
I
R
E
F
G
V
F
S
E
L
K
S-HKI
T
A
D
E
IRDINP
I
G
I
V
LSGGPNSVYADGAFG
I
D
----
E
E
I
F
E
L----GI
P
I
L
G
I
C
Y
G
M
Q
L
I
T
H
K
LG
G
K
V
LPAGEAG
H
-------------------
R
E
Y
G
Q
S
A
--------
L
R
LRS---------------------------ES
A
-
L
FAG-----T
P
Q
--------
E
-
Q
--------
L
--------
V
L
---MSHG
D
A
V
T
EIPE
G
F
H
LVGDSV-DCP
F
A
AMENTEK
Q
F
Y
G
I
Q
FHP
E
V
R
H
S
VY
G
N
D
I
L
K
N
F
A
V
N
I
CGARGDWSM
D
N
F
I
D
M
E
I
A
K
I
R
E
T
VGD
R
K
V
L
L
G
LSGGV
D
S
S
V
V
G
V
L
L
Q
R
AIG-D
Q
L
T
C
I
F
VDHGLLRKNEG
D
Q
V
M
D
M
LGGKF--G
L
N
I
I
R
VD
A
S
-----------
K
R
F
L
D
L
----------
L
SGVE
D
P
E
R
K
R
KIIGN
E
F
V
Y
V
FDD---EASKL---K---G----V
D
F
LAQG
T
L
Y
T
D
I
I
E---SGT
E
----
T
----
A
Q
T
I
K
S
HHNVGGLPE
D
M
--
Q
F
E
--
L
I
E
P
L
N
T
L
F
K
D
E
V
R
A
L
G
T
ALGMPD
E
V
VWRQPFPGP
G
L
A
I
R
V
M
G
E
I
T
E
E
K
L
E
T
V
------------------------
R
E
S
D
A
I
L
R
----------------
E
E
I
A
K
AGLD--
R
D
V
W
Q
Y
F
TVNT---------GV
R
S
V
GVMGDG
R
T
Y
D
Y
T
I
A
I
---------------------------------------------------------------------------------------------------------
R
A
I
TSIDGMT
A
D
F
A
----QL
P
W
D
V
L
K
K
I
S
T
R
I
V
N
E
V
D
H
V
N
R
I
V
Y
DITSKPPATVEWE
23
PsiBlast_CBE
95.80
52%
-112
- C2 -
1GPM
4
GUAA_ECOLI
B:
[8-525]
---------------
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
-
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
----------------------
R
E
F
G
Y
A
Q
--------
V
E
V
V
N
---------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
--------
A
-
L
--------
T
ADG
K
P
L
L
D
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
--------------------------------
M
--
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
22
PsiBlast_CBE
94.86
52%
-112
- C2 -
1GPM
5
GUAA_ECOLI
C:
[8-525]
---------------
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
-
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
----------------------
R
E
F
G
Y
A
Q
--------
V
E
V
V
N
---------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
--------
A
-
L
--------
T
ADGKPLLD
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
SAA--------------------------------
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
1
PsiBlast_PDB
94.85
52%
-111
- C2 -
1GPM
4
GUAA_ECOLI
A:
[8-525]
---------------
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
-
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
----------------------
R
E
F
G
Y
A
Q
--------
V
E
V
V
N
---------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
--------
A
-
L
--------
T
ADG
K
P
L
L
D
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A--------------------------------
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
34
HHSearch
94.83
54%
-106
- C2 -
1GPM
4
GUAA_ECOLI
A:
[3-525]
-----
E
N
I
H
K
-----
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
-
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
---
N
E
-------------------
R
E
F
G
Y
A
Q
--------
V
E
V
V
N
---------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
ALTADG
K
P
L
-
L
--------
D
--------
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
---
S
A
A
-----------------------------
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
21
PsiBlast_CBE
94.76
52%
-113
- C2 -
1GPM
5
GUAA_ECOLI
D:
[8-525]
---------------
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
-
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
----------------------
R
E
F
G
Y
A
Q
--------
V
E
V
V
N
---------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
--------
A
-
L
--------
T
ADGKPLLD
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
--------------------------------
M
--
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
4
PsiBlast_PDB
92.49
49%
-110
- C2 -
2YWC
1
GUAA_THET8
A:
[2-503]
-------------------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
-
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
G
R
A
----------------------
E
Y
G
K
-
A
--------
L
L
T
R
H
---------------------------
E
G
P
-
L
F
R
G
-----
L
E
G
--------
E
-
V
--------
Q
--------
V
W
---
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
-
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
-
L
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
G
V
-
D
H
L
-
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
R
A
-
L
--
G
V
N
L
L
V
V
D
A
K
-----------
E
R
F
L
K
A
----------
L
K
G
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
---
V
A
R
E
R
---
G
---
P
----
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
--------------------------
G
G
L
P
E
D
L
--
E
F
E
--
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
E
E
R
L
E
I
L
------------------------
R
R
A
D
D
I
F
T
----------------
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
A
V
L
T
---------
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
3
PsiBlast_PDB
91.08
50%
-113
- C2 -
2YWB
-
GUAA_THET8
A:
[2-503]
-------------------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
-
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
-------------------------
E
Y
G
K
-
A
--------
L
L
T
R
H
---------------------------
E
G
P
-
L
F
R
G
-----
L
E
G
--------
E
-
V
--------
Q
--------
V
W
---
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
-
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
-
L
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
G
V
-
D
H
L
-
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
R
A
-
L
--
G
V
N
L
L
V
V
D
A
K
-----------
E
R
F
L
K
A
----------
L
K
G
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
---
V
A
R
E
R
---
G
---
P
----
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
---------------------------
G
L
P
E
D
L
--
E
F
E
--
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
E
E
R
L
E
I
L
------------------------
R
R
A
D
D
I
F
T
----------------
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
A
V
L
T
---------
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
36
HHSearch
90.88
49%
-114
- C2 -
3TQI
-
GUAA_COXBU
A:
[5-523]
-------
I
H
Q
-----
H
--
R
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
-
C
D
I
D
E
E
T
I
R
D
F
N
P
H
G
I
I
L
S
G
G
P
E
---------
A
P
----
A
F
I
F
E
I
----
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
---------------------------
E
F
G
H
A
Q
--------
L
R
V
L
N
---------------------------
P
A
F
-
L
F
D
G
-----
I
E
D
QVSPQG
E
P
L
-
L
--------
D
--------
V
W
---
M
S
H
G
D
I
V
S
E
L
P
P
G
F
E
A
T
A
C
T
D
-
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
T
P
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
E
D
S
I
R
D
I
Q
E
K
V
G
K
E
Q
V
I
V
G
L
S
G
G
V
D
S
A
V
T
A
T
L
V
H
K
A
I
G
-
D
Q
L
V
C
V
L
V
D
T
G
L
L
R
L
N
E
V
D
E
V
L
N
V
F
Q
K
H
L
--
G
A
K
V
I
C
V
D
A
K
-----------
D
R
F
M
K
A
----------
L
K
G
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
---
Q
A
K
K
L
-------
N
----
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
---
S
---------------------------------
K
--
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
V
S
A
E
Y
I
N
I
L
------------------------
K
Q
A
D
A
I
F
I
----------------
E
E
L
K
K
S
D
Y
Y
--
H
Q
V
S
Q
A
F
A
V
F
M
---------
P
L
K
S
V
--------
Y
G
Y
I
I
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
-------
Q
W
A
----
D
L
P
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
2
PsiBlast_PDB
90.86
48%
-120
- C2 -
3TQI
-
GUAA_COXBU
A:
[5-523]
---------
I
-----
H
Q
H
R
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
-
C
D
I
D
E
E
T
I
R
D
F
N
P
H
G
I
I
L
S
G
G
P
E
---------
A
P
----
A
F
I
F
E
I
----
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
---------------------------
E
F
G
H
A
Q
--------
L
R
V
L
N
---------------------------
P
A
F
-
L
F
D
G
IEDQV
S
P
Q
--------
G
-
E
--------
P
--------
L
L
DVW
M
S
H
G
D
I
V
S
E
L
P
P
G
F
E
A
T
A
C
T
D
-
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
T
P
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
E
D
S
I
R
D
I
Q
E
K
V
G
K
E
Q
V
I
V
G
L
S
G
G
V
D
S
A
V
T
A
T
L
V
H
K
A
I
G
-
D
Q
L
V
C
V
L
V
D
T
G
L
L
R
L
N
E
V
D
E
V
L
N
V
F
Q
K
H
L
--
G
A
K
V
I
C
V
D
A
K
-----------
D
R
F
M
K
A
----------
L
K
G
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
---
Q
A
K
K
L
-------
N
----
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
---
S
---------------------------------
K
--
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
V
S
A
E
Y
I
N
I
L
------------------------
K
Q
A
D
A
I
F
I
----------------
E
E
L
K
K
S
D
Y
Y
--
H
Q
V
S
Q
A
F
A
V
F
M
---------
P
L
K
S
V
--------
Y
G
Y
I
I
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
-------
Q
W
A
----
D
L
P
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
35
HHSearch
90.81
50%
-112
- C2 -
2YWB
-
GUAA_THET8
A:
[1-503]
------------------
M
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
-
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
-------------------------
E
Y
G
K
A
L
--------
L
T
R
H
----------------------------
E
G
P
-
L
F
R
G
-----
L
E
G
--------
E
-
V
--------
Q
--------
V
W
---
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
-
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
L
-
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
-
G
-
V
D
H
L
A
V
F
V
D
H
G
L
L
R
-
L
G
E
R
E
E
V
E
G
A
L
R
A
L
--
G
V
N
L
L
V
V
D
A
K
-----------
E
R
F
L
K
A
----------
L
K
G
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
---
V
A
R
E
R
-------
G
P---
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
---------------------------
G
L
P
E
D
L
--
E
F
E
--
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
E
E
R
L
E
I
L
------------------------
R
R
A
D
D
I
F
T
----------------
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
A
V
L
T
---------
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
5
PsiBlast_PDB
86.76
41%
-113
- C2 -
3UOW
2
?
A:
[9-556]
------------------
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
-
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
P
H
L
K
----
K
E
V
F
E
Y
F
L
E
K
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
NDNINNITYC
R
N
F
---
S
S
A
M
D
L
Y
S
N
Y
K
L
M
N
-----------------------------
C
C
L
F
E
N
-----
I
K
S
--------
D
I
T
--------
T
--------
V
W
---
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
-
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
T
F
L
K
S
T
F
P
-
D
M
N
I
T
K
I
D
A
S
-----------
E
N
F
L
S
N
----------
L
Q
G
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
---
A
V
N
N
I
---
D
IDI
N
----
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
---
S
K
C
S
-------------------------
L
--
K
F
K
--
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
I
N
K
H
K
L
N
I
L
------------------------
R
E
V
D
D
I
F
I
----------------
N
D
L
K
Q
Y
G
L
Y
--
N
Q
I
S
Q
A
F
A
V
L
L
---------
S
S
K
S
V
--------
Y
D
Y
V
C
V
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
37
HHSearch
85.83
44%
-108
- C2 -
3UOW
2
?
A:
[7-556]
---------
Y
-----
D
--
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
-
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
P
H
L
K
K
E
V
F
E
Y
F
L
E
K
----
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
---
K
T
-------------------
S
E
Y
G
C
T
D
--------
V
N
I
L
R
NDNINNITYCRNFSS
A
M
D
L
Y
S
N
Y
K
L
M
N-
C
C
-
L
F
E
N
-----
I
K
S
D-------
I
-
T
--------
T
--------
V
W
---
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
-
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
-
T
F
L
K
S
T
F
P
D
M
N
I
T
K
I
D
A
S
-----------
E
N
F
L
S
N
----------
L
Q
G
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
---
A
V
N
N
I
DID
I
---
N
----
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
---
S
K
C
S
-------------------------
L
--
K
F
K
--
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
I
N
K
H
K
L
N
I
L
------------------------
R
E
V
D
D
I
F
I
----------------
N
D
L
K
Q
Y
G
L
Y
--
N
Q
I
S
Q
A
F
A
V
L
L
---------
S
S
K
S
V
--------
Y
D
Y
V
C
V
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
24
PsiBlast_CBE
78.04
35%
-106
- C2 -
2VXO
4
GUAA_HUMAN
B:
[32-566]
-------------------
V
V
I
L
D
A
G
A
Q
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
-
L
E
T
P
A
F
A
I
K
E
Q
G
F
R
A
I
I
I
S
G
G
P
N
S
V
Y
A
E
D
A
P
W
F
D
----
P
A
I
F
T
I
----
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
---
H
K
K
S
----------------------
D
G
V
F
N
--------
I
S
V
D
N
---------------------------
T
C
S
-
L
F
R
G
-----
L
Q
K
--------
E
-
E
--------
V
--------
V
L
---
L
T
H
G
D
S
V
D
K
V
A
D
G
F
K
V
V
A
R
S
G
-
N
I
-
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
T
E
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
K
R
E
S
Q
S
V
E
E
A
L
-
K
K
L
--
G
I
Q
V
K
V
I
N
A
A
H
S
F
Y
N
G
T
T
T
L
P-
R
I
S
K
T
----------
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
V
I
G
E
M
N
L
K
---
P
---
E
----
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
---
S
A
S
L
----
V
A
S
GK
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
--
R
E
E
GK
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
P
Y
I
C
K
D
F
------------------------
P
E
T
N
N
I
L
K
I
V
A
D
F
S
A
S
V
K
K
PH
T
L
L
Q
R
V
K
A
C
T
T
E
--
E
D
Q
E
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
---------------------------------------------------------------------------------------------------------
S
S
K
D
E
P
D
--------------
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
H
N
V
N
R
V
V
Y
I
F
G
P
P
V
K
E
P
P
T
D
V
38
HHSearch
77.70
40%
-99
- C2 -
2VXO
5
GUAA_HUMAN
A:
[29-697]
---------
E
-----
G
--
A
V
V
I
L
D
A
G
--
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
-
L
E
T
P
A
F
A
I
K
E
Q
G
F
R
A
I
I
I
S
G
G
P
-------
A
P
W
F
D
----
P
A
I
F
T
I
----
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
-----------------------------
V
F
N
--------
I
S
V
D
N
---------------------------
T
C
S
-
L
F
R
G
-----
L
Q
K
--------
E
-
E
--------
V
--------
V
L
---
L
T
H
G
D
S
V
D
K
V
A
D
G
F
K
V
V
A
R
S
G
-
N
-
I
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
T
E
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
K
-
R
E
S
Q
S
V
E
E
A
L
K
K
L
--
G
I
Q
V
K
V
I
N
A
A
-----------
H
S
F
Y
N
G
T
T
T
L
PRISKT
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
---
V
I
G
E
M
-------
N
LKPE
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
---
S
A
S
L
V
A
S
G
K
----
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
R
E
E
G
K
--
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
P
Y
I
C
K
D
F
P
E
T
N
N
I
L
K
I
V
A
D
F
S
A
S
V
K
K
PH
T
L
L
Q
R
V
K
A
C
T
T
----------------
E
E
D
Q
E
-
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
---------
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
S
S
KDEPD
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
HNVN
R
V
V
Y
I
F
G
PPVKEPPTDVTPTFLT
T
G
V
L
S
T
L
R
Q
A
D
F
E
A
H
N
I
L
R
E
S
GYAGKIS
Q
M
P
V
I
L
T
PLHFDRDPLQKQPSC
Q
R
S
V
V
I
R
T
F
I
T
S
D
F
M
T
G
I
P
A
TPGN
E
I
P
V
E
V
V
L
K
M
V
T
E
I
-
K
K
I
P
G
I
S
R
I
M
Y
D
L
T
S
K
P
P
G
T
T
E
W
E
8
PsiBlast_PDB
77.40
35%
-105
- C2 -
2VXO
4
GUAA_HUMAN
A:
[32-566]
-------------------
V
V
I
L
D
A
G
--
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
-
L
E
T
P
A
F
A
I
K
E
Q
G
F
R
A
I
I
I
S
G
G
P
-------
A
P
W
F
D
----
P
A
I
F
T
I
----
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
---
H
K
--------------------------
V
F
N
--------
I
S
V
D
N
---------------------------
T
C
S
-
L
F
R
G
-----
L
Q
K
--------
E
-
E
--------
V
--------
V
L
---
L
T
H
G
D
S
V
D
K
V
A
D
G
F
K
V
V
A
R
S
G
-
N
I
-
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
T
E
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
K
R
E
S
Q
S
V
E
E
A
L
-
K
K
L
--
G
I
Q
V
K
V
I
N
A
A
H
S
F
Y
N
G
T
T
T
L
P-
R
I
S
K
T
----------
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
V
I
G
E
M
N
L
K
---
P
---
E
----
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
---
S
A
S
L
----
V
A
S
GK
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
--
R
E
E
GK
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
P
Y
I
C
K
D
F
------------------------
P
E
T
N
N
I
L
K
I
V
A
D
F
S
A
S
V
K
K
PH
T
L
L
Q
R
V
K
A
C
T
T
E
--
E
D
Q
E
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
---------------------------------------------------------------------------------------------------------
S
S
K
D
E
P
D
--------------
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
H
N
V
N
R
V
V
Y
I
F
G
P
P
V
K
E
P
P
T
D
V
39
HHSearch
68.36
53%
-112
- C2 -
2DPL
-
GUAAB_PYRHO
A:
[2-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
--
G
M
N
L
H
Y
V
D
A
Q
-----------
D
R
F
F
S
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
I
-------
G
----
A
E
Y
L
I
Q
G
T
I
A
P
------------------------------------
L
--
N
L
K
--
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
P
E
K
I
R
I
V
------------------------
R
E
A
N
A
I
V
E
----------------
E
E
V
E
R
A
G
L
----
R
P
W
Q
A
F
A
V
L
L
---------
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
7
PsiBlast_PDB
68.28
52%
-107
- C2 -
3A4I
-
GUAAB_PYRHO
A:
[2-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
--
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
--
G
M
N
L
H
Y
V
D
A
Q
-----------
D
R
F
F
S
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
I
-------
G
----
A
E
Y
L
I
Q
G
T
I
A
P
---------------------------------------
N
L
K
--
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
P
E
K
I
R
I
V
------------------------
R
E
A
N
A
I
V
E
----------------
E
E
V
E
R
A
G
L
R
--
P
--
W
Q
A
F
A
V
L
L
---------
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
6
PsiBlast_PDB
68.18
52%
-107
- C2 -
2DPL
-
GUAAB_PYRHO
A:
[2-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
--
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
--
G
M
N
L
H
Y
V
D
A
Q
-----------
D
R
F
F
S
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
I
-------
G
----
A
E
Y
L
I
Q
G
T
I
A
P
------------------------------------
L
--
N
L
K
--
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
P
E
K
I
R
I
V
------------------------
R
E
A
N
A
I
V
E
----------------
E
E
V
E
R
A
G
L
R
--
P
--
W
Q
A
F
A
V
L
L
---------
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
63
Fugue
59.54
60%
-129
- C2 -
1GPM
2
GUAA_ECOLI
A:
[208-404]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
---
S
A
---------------------------
A
--
K
M
G
--
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
------------------------
R
R
A
D
A
I
F
I
----------------
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
T
V
F
L
---------
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
65
Fugue
58.03
46%
-113
* C2 *
1GPM
1
GUAA_ECOLI
A:
[3-207]
----------ENIHK
H
--
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
-
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
-
E
A---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
--------------------
G
Y
A
Q
V
E
--------
V
V
N
-----------------------------
D
S
A
-
L
V
R
G
-----
I
E
D
--------
A
-
L
TADG
K
P
L
L
D
--------
V
W
---
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
-E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
--
G
L
N
I
V
H
V
P
A
E
-----------
D
R
F
L
S
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
---
S
A
A
K
----
M
----
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
--
G
L
E
--
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
------------------------
V
S
Q
A
F
T
V
F
----------------
L
P
V
R
S
V
G
V
M
--
G
D
G
R
K
Y
D
W
V
V
S
---------
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
H
L
P
Y
D
---------------------------------------------------------------------------------------------------------
F
L
G
R
V
S
N
R
I
I
N
E
V
N
----
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
-------------------