@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0961: (2015-12-04 )
MLLEINHLEKVFRTRFSKEETRALQDVDFKVEQGEFIAIMGESGSGKTTLLNILATLEKPTNGQVILNGEDITKIKEAKLASFRLKNLGFVFQDFNLLDTLSVRDNIYLPLVLDRKRYKEMDHRLSELSSHLRIDDLLDKRPFELSGGQKQRVAIARSLITNPQILLADEPTAALDYRNSEDLLNLFETINLDGQTILMVTHSANAASHAKRVLFIKDGRIFHQLYRGNKNNSEFNKDISLTMSAILGGE
Atome Classification :
(25 SA)
--.........10...-.....20-........30........40........50........60...-------.....70........80......-..90........100.......-110.......120.......130.......140--.........150.......160.......170.......180.......190.-.-......200-.....-..-210.......220-----..------...--.-.230.......240.......250---------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
L
L
E
I
N
H
L
E
K
V
F
R
T
-RFS
K
E
E
T
-RALQDVD
F
K
VEQG
E
F
I
A
I
MGESGSG
K
T
T
L
L
N
I
L
A
T
LEKPTN
G
Q
-------
V
I
LNG
E
D
I
T
K
I
K
E
A
K
L
A
S
F
R
L
K
N-L
G
F
V
F
Q
DFNL
L
D
T
LSVRD
N
I
Y
L
-
P
L
VL
D
R
K
R
Y
K
E
M
D
H
R
L
S
E
L
S
S
HL
R
I
D
D
L
L
DK----RPFELSGG
Q
K
Q
R
V
A
I
A
R
S
LITNP
Q
I
L
L
ADEPT
A
A
LDYR
N
S
E
D
L
L
N
L
F
E
T
IN-L-D-G
Q
T
I
L
M
V
TH-SANAA-SH-
A
K
R
V
L
F
IKD
G
R
I
F
-----
H
Q
------
L
YR--G-NKNNSEFNK
D
I
S
L
T
M
S
A
I
LGGE-----------------------------------------------------------------------------------------------
127
Fugue
88.71
36%
-92
- C1 -
1Z47
1
?
A:
[11-355]
GS
M
T
I
E
F
V
G
V
E
K
I
Y
------
P
G
G
A
-
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
-------
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
------
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
-
E
M
G
V
T
S
V
F
V
T
H
-
D
Q
E
E
A
-
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
-----
Q
F
G
T
P
E
E
-
V
Y
E
KP
G
-
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
124
Fugue
86.39
35%
-92
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
--
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
EQDTV
S
E
------
V
F
S
--
H
-
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
QERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV---------
117
HHSearch
85.81
41%
-97
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[3-223]
--
E
I
L
R
A
E
N
I
K
K
V
I
R
-------
G
Y
-
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
-------
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
-
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
----
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
-
E
R
E
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
------
I
T
R
--
V
----------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.80
37%
-100
- C1 -
3TUI
1
METN_ECOLI
H:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.36
37%
-101
- C1 -
3TUI
1
METN_ECOLI
C:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.93
37%
-104
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
105
HHSearch
82.39
37%
-93
* C1 *
3TUI
1
METN_ECOLI
C:
[24-252]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
-
G
T
--
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.28
37%
-106
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.06
42%
-99
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[20-223]
---------------------------
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
-------
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
-
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
----
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
-
E
R
E
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
------
I
T
R
--
V
----------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.23
37%
-98
- C1 -
3TUI
1
METN_ECOLI
G:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.01
37%
-102
- C1 -
3TUI
1
METN_ECOLI
D:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
26
PsiBlast_CBE
80.96
37%
-100
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.79
37%
-101
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-245]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
103
HHSearch
80.78
36%
-93
- C1 -
1Z47
1
?
A:
[13-236]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
------
G
G
A
-
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
-------
V
W
I
G
G
K
R
V
T
D
L
P
P
-----
Q
K
-
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
E
M
-
G
V
T
S
V
F
V
T
H
-
D
Q
E
E
A
L
E
V
-
A
D
R
V
L
V
L
H
E
G
N
V
E
-----
Q
F
------
G
T
P
--
E
-
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.51
38%
-100
- C1 -
3DHW
-
METN_ECOLI
C:
[1-222]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
---
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
-------
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
----
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
-
E
M
D
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
------
D
T
V
--
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.80
39%
-94
- C1 -
3TIF
7
Y796_METJA
A:
[4-223]
---------
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
-------
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
-
D
I
N
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
------
E
K
L
--
R
----------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
79.52
32%
-81
- C1 -
1OXU
7
?
B:
[6-242]
------
V
K
N
V
S
K
V
F
K
-----
K
G
K
V
-
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
LYFDDRL
V
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
---------
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
----
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
-
A
I
-
A
D
R
V
G
V
L
V
K
G
K
---------------
L
V
Q
--
V
-
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
-----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.51
39%
-96
- C1 -
1F3O
2
Y796_METJA
A:
[4-223]
---------
L
K
N
V
T
K
T
-
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
-------
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
-
D
I
N
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
------
E
K
L
--
R
-
G
F
-------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.36
39%
-96
- C1 -
3TIF
7
Y796_METJA
B:
[4-223]
---------
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
-------
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
-
D
I
N
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
------
E
K
L
--
R
-
G
F
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.24
37%
-97
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
---
M
G
E
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
-------
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
-
D
I
N
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
------
E
K
L
--
R
----------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
78.68
38%
-101
- C1 -
4YMV
1
?
A:
[16-235]
--------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
-------
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
-
E
M
G
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
GT
P
E
E
I
F
Y
R
--
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.33
38%
-100
- C1 -
4YMU
2
?
A:
[16-235]
--------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
-------
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
-
E
M
G
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
GT
P
E
E
I
F
Y
R
--
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.81
38%
-102
- C1 -
4YMV
1
?
J:
[16-235]
--------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
-------
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
-
E
M
G
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
GTPEEI
F
Y
R
--
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.98
37%
-97
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
---
M
G
E
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
-------
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
-
D
I
N
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
------
E
K
L
--
R
-
G
F
-------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.80
38%
-100
- C1 -
4YMU
2
?
J:
[16-235]
--------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
-------
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
-
E
M
G
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
GTPEEI
F
Y
R
--
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---------------------------------------------------------------------------------------------------------