@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1029: (2015-12-05 )
MDAKFDFAKLLVYKAGQFIKSEMQNTFDVEEKSRFDDLVTSLDKKTQKLLIQEIIQHYPDDNILAEEDDVRSPIAQGNVWVLDPIDGTVNFIVQKDNFAVMLAYYEEGVGQFGIIYDVMADILYSGGGHFDVYANDKKIVPFQECPLERCLLGVNSAMYAENDCGIAHLASETLGVRIYGGAGISMAKVMQGKLLAYFSYIQPWDYAAAKIMGETLGFTLLTLDGEEPNYSTRQKVMFLPKSKLNLIQSYLTKK
Atome Classification :
(20 SA)
.........10........20.....--...30........40........50........60......---..70--.-.--.--.....-.80........90........100.......110....-...-120.......130......----.-140.......150---------.......160.-----.----...--....170-...------.....180.......190.......-200........210.......220.......230------.........-240.......250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDA
K
F
D
F
A
K
L
L
V
Y
K
A
G
Q
F
I
K
S
E
M
Q
NT--FD
V
E
E
K
S
R
F
D
D
L
V
T
S
L
D
K
K
T
Q
K
L
L
I
Q
E
I
I
Q
HYPDDNILAEE---
D
D
V---R-S--P--IAQG
N
-
V
W
V
LDPIDG
T
V
N
F
I
V
QKD
N
F
A
V
M
L
A
Y
Y
E
EGVGQF
G
I
I
Y
-
D
V
M
-
A
D
I
L
YSGGG
H
F
D
V
Y
AND
K
K
----
I
-V
P
F
Q
EC
P
L
E
R
C
L
L
---------GVN
S
A
MYA--E-----N----DCG--
I
A
H
L
AS--E
T
L
------
G
V
R
I
YGGAG
I
S
M
A
K
V
MQ
G
K
L
L
A
Y
F
S
-Y-IQP
W
D
Y
A
A
A
K
I
M
GETL
G
F
T
L
L
T
LDGEEPNY--------S
T
R
Q
K
V
M
FL-P
K
S
K
L
N
L
I
Q
S
Y
LTKK
26
HHSearch
96.86
29%
-111
- C2 -
3T0J
5
?
A:
[9-264]
-
M
A
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
--
L
T
------
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
---
G
H
G
H--
D
I
D
-----
T
S
K
G
T
-
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
-
D
V
M
A
D
V
L
-
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
----
L
-
K
P
L
N
D
S
N
L
R
Q
S
I
I
---------
G
I
N
P
N
W
L
T
K-
P
I
----
L
----
G
E
I
--
F
K
E
-
I
V
N
-
D
S
R
------
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
-
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
--------
S
G
-
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
36
HHSearch
92.20
27%
-102
- C2 -
2Q74
-
SUHB_MYCTU
A:
[10-281]
--
R
L
R
S
V
A
E
N
L
A
A
E
A
A
A
F
V
R
G
R
R
A
E
V
F-----------
D
P
V
T
V
V
D
T
D
T
E
R
L
L
R
D
R
L
A
Q
L
R
P
G
D
P
I
L
G
E
E
---
G
----------------
R
V
-
T
W
V
L
D
P
I
D
G
T
V
N
F
V
Y
G
I
P
A
Y
A
V
S
I
G
A
Q
V
G
G
I
T
V
A
G
A
V
A
-
D
V
A
A
R
T
V
-
Y
S
A
A
T
G
L
G
A
H
L
T
D
E
R
G
R
H
V
L
-
R
C
T
G
V
D
E
L
S
M
A
L
L
---------
G
T
G
F
G
Y
S
V
RC
R
E
K
---
Q
----
A
E
L
--
L
A
H
-
V
V
P-
L
V
R
------
D
V
R
R
I
G
S
A
A
L
D
L
C
M
V
A
A
G
R
L
D
A
Y
Y
E
-
H
G
V
Q
V
W
D
C
A
A
G
A
L
I
A
A
E
A
G
A
R
V
L
L
S
----------------
A
-
G
L
V
V
V
A
A
A
P
G
I
A
D
E
L
L
A
A
L
Q
R
F
21
PsiBlast_CBE
91.80
33%
-126
- C2 -
3T0J
3
?
D:
[10-223]
--
A
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
--
L
--------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
GHG
H
D
I
---
D
-
T
------
S
K
G
T
-
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
-
D
V
M
-
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
----
L
-
K
P
L
N
D
S
N
L
R
Q
S
I
I
---------
G
I
N
P
N
W
L
T
--
K
-----
P
----
I
L
G
EI
F
K
E
I
V
N
--
D
S
R
------
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
-
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
--------
S
G
P
N
S
I
L
V
G
-
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
1
PsiBlast_PDB
91.70
33%
-124
- C2 -
3T0J
5
?
A:
[10-223]
--
A
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
--
L
T
------
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
GHG
H
D
I
---
D
-
T
------
S
K
G
T
-
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
-
D
V
M
-
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
----
L
-
K
P
L
N
D
S
N
L
R
Q
S
I
I
---------
G
I
N
P
N
W
L
T
--
K
-----
P
----
I
L
G
E
I
F
K
E
I
V
N
--
D
S
R
------
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
-
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
--------
S
G
P
N
S
I
L
V
G
-
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
29
HHSearch
91.63
24%
-122
- C2 -
2FVZ
-
IMPA2_HUMAN
A:
[17-277]
-
E
E
C
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
---------------
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
---
A
----------
K
CV
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
E
E
R
L
-
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
---------
L
T
E
I
G
P
K
R
--
D
P
A
---
T
L
K
L
F
L
S
N
--
M
E
R
L
L
H
A
-
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
--------
M
A
-
C
R
V
V
A
A
S
T
R
E
M
A
M
L
I
A
Q
A
L
---
32
HHSearch
91.29
27%
-104
- C2 -
2BJI
3
IMPA1_BOVIN
A:
[6-268]
-
Q
E
C
M
D
Y
A
V
T
L
A
G
Q
A
G
E
V
V
R
E
A
L
K
N
E
--
M
N
I
M
V
K
S
S
P
A
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
T
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
---
S
V
A
A
--
G
-
E
KS
I
--
L
T
D
N
P
-
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
G
F
P
F
V
A
V
S
I
G
F
V
V
N
K
K
M
E
F
G
I
V
Y
-
S
C
L
E
D
K
M
-
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
----
L
-
Q
V
S
H
Q
E
D
I
T
K
S
L
L
---------
V
T
E
L
G
S
S
R
--
T
P
E
---
T
V
R
I
I
L
S
N
--
I
E
R
L
L
C
L
-
P
I
H
------
G
I
R
G
V
G
T
A
A
L
N
M
C
L
V
A
A
G
A
A
D
A
Y
Y
E
-
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
L
D
V
T
G
G
P
F
D
L
--------
M
S
-
R
R
V
I
A
S
S
N
K
T
L
A
E
R
I
A
K
E
I
Q
I
I
23
PsiBlast_CBE
91.01
33%
-126
- C2 -
3T0J
4
?
B:
[10-223]
--
A
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
--
L
------
N
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
GHG
H
D
I
---
D
-
T
------
S
K
G
T
-
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
-
D
V
M
-
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
----
L
-
K
P
L
N
D
S
N
L
R
Q
S
I
I
---------
G
I
N
P
N
W
L
T
--
K
-----
P
----
I
L
G
E
I
F
K
E
I
V
N
--
D
S
R
------
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
-
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
--------
S
G
P
N
S
I
L
V
G
-
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
22
PsiBlast_CBE
90.31
33%
-124
- C2 -
3T0J
3
?
C:
[10-223]
--
A
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
--
L
T
-------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
GHG
H
D
I
---
D
-
T
------
S
K
G
T
-
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
-
D
V
M
-
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
----
L
-
K
P
L
N
D
S
N
L
R
Q
S
I
I
---------
G
I
N
P
N
W
L
T
--
K
-----
P
----
I
L
G
EI
F
K
E
I
V
N
--
D
S
R
------
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
-
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
--------
S
G
P
N
S
I
L
V
G
-
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
27
HHSearch
89.94
28%
-98
* C2 *
2P3N
1
BSUHB_THEMA
A:
[2-248]
--
D
R
L
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
--
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
---
G
I
F
-----------
E
K
G
D
R
-
L
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
-
A
P
A
L
N
E
T
-
L
Y
A
E
E
G
S
G
A
F
F
N
G
E
R
----
I
-
R
V
S
E
N
A
S
L
E
E
C
V
G
---------
S
T
G
S
Y
V
D
F
--------
T
----
G
K
F
--
I
E
R
-
M
E
K-
R
T
R
------
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
-
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
--------
F
S
--
K
N
F
I
F
S
N
G
L
I
H
D
E
V
V
K
V
V
N
E
V
7
PsiBlast_PDB
88.88
24%
-113
- C2 -
2CZH
1
IMPA2_HUMAN
A:
[31-287]
----
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
--
K
---------
D
L
V
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
AAA
S
G
A
---
K
-
C
--
V
--
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
-
E
E
R
L
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
PKRD
P
A
T
L
K
L
F
L
--
S
-----
N
----
M
E
R
--
L
L
H
--
A
--
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
MAC
R
V
V
A
A
S
T
R
E
M
A
M
L
I
-
A
Q
A
L
-----------
10
PsiBlast_PDB
88.71
24%
-117
- C2 -
2DDK
-
IMPA2_HUMAN
A:
[20-276]
----
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
-----------
S
A
A
D
L
V
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
AAA
S
G
A
---
K
-
C
--
V
--
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
-
E
E
R
L
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
PKRD
P
A
T
L
K
L
F
L
--
S
-----
N
----
M
E
R
--
L
L
H
--
A
--
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
MAC
R
V
V
A
A
S
T
R
E
M
A
M
L
I
-
A
Q
A
L
Q
T
I
N
-------
6
PsiBlast_PDB
88.63
24%
-113
- C2 -
2FVZ
-
IMPA2_HUMAN
A:
[20-276]
----
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
---------------
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
A--------
K
-
C
--
V
--
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
-
E
E
R
L
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
IGPKRD
P
A
T
L
K
L
F
L
--
S
-----
N
----
M
E
R
--
L
L
H
--
A
--
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
MAC
R
V
V
A
A
S
T
R
E
M
A
M
L
I
-
A
Q
A
L
-----------
9
PsiBlast_PDB
88.03
24%
-115
- C2 -
2CZK
-
IMPA2_HUMAN
A:
[20-276]
----
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
------------
D
L
V
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
------
A
---
K
-
C
--
V
--
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
-
E
E
R
L
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
PKRD
P
A
T
L
K
L
F
L
--
S
-----
N
----
M
E
R
--
L
L
H
--
A
--
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
MAC
R
V
V
A
A
S
T
R
E
M
A
M
L
I
-
A
Q
A
L
Q
T
I
N
Y
G
-----
4
PsiBlast_PDB
87.95
29%
-104
- C2 -
4AS5
10
IMPA1_MOUSE
A:
[9-249]
----
M
D
Y
A
V
I
L
A
R
Q
A
G
E
M
I
R
E
A
L
K
N
E
--
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
---
S
V
A
A
G
E
K
-
T
--
V
--
F
T
E
Q
P
-
T
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
-
S
C
V
-
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
----
L
-
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
-------
E
L
G
S
S
R
K
P
--
E
-----
T
L
R
I
V
L
S
N
--
M
E
K
L
C
S
--
I
P
I
H-----
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
-
M
G
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
--------
M
S
R
R
I
I
A
A
N
-
S
I
T
L
A
K
R
I
A
K
E
I
E
I
I
5
PsiBlast_PDB
87.67
28%
-100
- C2 -
2BJI
3
IMPA1_BOVIN
A:
[9-251]
----
M
D
Y
A
V
T
L
A
G
Q
A
G
E
V
V
R
E
A
L
K
N
E
--
M
N
I
M
V
K
S
S
P
A
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
T
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
---
S
V
A
A
GE
K
-
S
--
I
--
L
T
D
N
P
-
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
G
F
P
F
V
A
V
S
I
G
F
V
V
N
K
K
M
E
F
G
I
V
Y
-
S
C
L
-
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
----
L
Q
V
S
H
Q
E
D
I
T
K
S
L
L
V
---------
T
E
L
G
S
S
R
T
--
P
-----
E
----
T
V
R
--
I
I
L
S
N
I
--
E
R
L
L
C
L
PIH
G
I
R
G
V
G
T
A
A
L
N
M
C
L
V
A
A
G
A
A
D
A
Y
Y
E
-
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
L
D
V
T
G
G
P
F
D
L
--------
M
S
R
R
V
I
A
S
S
-
N
K
T
L
A
E
R
I
A
K
E
I
Q
I
I
8
PsiBlast_PDB
86.78
24%
-114
- C2 -
2CZI
3
IMPA2_HUMAN
A:
[31-287]
----
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
------
T
K
T
S
A
A
D
L
V
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
A--------
K
-
C
--
V
--
L
T
H
S
P
-
T
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
-
H
C
T
-
E
E
R
L
Y
T
G
R
R
G
R
G
A
F
C
N
G
Q
R
----
L
-
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
PKRD
P
A
T
L
K
L
F
L
--
S
-----
N
----
M
E
R
--
L
L
H
--
A
--
K
A
H
------
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
-
F
G
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
G
I
V
I
D
T
S
G
G
P
L
D
L
MAC
R
V
V
A
A
S
T
R
E
M
A
M
L
I
-
A
Q
A
L
Q
T
I
N
Y
------
3
PsiBlast_PDB
86.71
30%
-97
- C2 -
2P3V
2
BSUHB_THEMA
A:
[3-225]
---
R
L
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
--
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
-----------
G
--
I
--
F
E
K
G
D
R
L
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
-
N
E
T
L
Y
A
E
E
G
S
-
G
A
F
F
N
G
E
R
----
I
-
R
V
S
E
N
A
S
L
E
E
C
-
V
---------
G
S
T
G
S
Y
V
D
--
F
-----
T
----
G
K
F
--
I
E
R
M
E
K
--
R
T
R
------
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
-
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
--------
F
S
K
N
F
I
F
S
N
-
G
L
I
H
D
E
V
V
K
V
V
N
E
V
V
28
HHSearch
86.30
23%
-104
- C2 -
2QFL
2
SUHB_ECOLI
A:
[1-259]
M
H
P
M
L
N
I
A
V
R
A
A
R
K
A
G
N
L
I
A
K
N
Y
E
T
P
DA
V
E
A
S
Q
-
K
G
S
N
D
F
V
T
N
V
D
K
A
A
E
A
V
I
I
D
T
I
R
K
S
Y
P
Q
H
T
I
I
T
E
E
---
S
G
E
L--
E
-
G
-----
T
D
Q
D
V
-
Q
W
V
I
D
P
L
D
G
T
T
N
F
I
K
R
L
P
H
F
A
V
S
I
A
V
R
I
K
G
R
T
E
V
A
V
V
Y
-
D
P
M
R
N
E
L
-
F
T
A
T
R
G
Q
G
A
Q
L
N
G
Y
R
----
L
-
R
G
S
T
A
R
D
L
D
G
T
I
L
---------
A
T
G
F
P
F
K
A
--
K
QY
A
T
T
Y
----
I
N
I
--
V
G
K
L
F
N
--
E
C
A
------
D
F
R
A
T
G
S
A
A
L
D
L
A
Y
V
A
A
G
R
V
D
G
F
F
E
-
I
G
L
R
P
W
D
F
A
A
G
E
L
L
V
R
E
A
G
G
I
V
S
D
F
T
G
G
H
N
-
Y
--------
M
L
-
T
G
N
I
V
A
G
N
P
R
V
V
K
A
M
L
A
N
M
R
D
E
13
PsiBlast_PDB
86.18
27%
-102
- C2 -
1IMA
2
IMPA1_HUMAN
A:
[9-251]
----
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
--
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
---
S
V
A
A
GE
K
-
S
--
I
--
L
T
D
N
P
-
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
-
S
C
V
-
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
----
L
-
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
----------
V
T
E
L
G
S
S
--
R
-----
T
----
P
E
T
--
V
R
M
V
L
S
N
M
E
K
L
F
C
I
PVH
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
-
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
--------
M
S
R
R
V
I
A
A
N
-
N
R
I
L
A
E
R
I
A
K
E
I
Q
V
I
31
HHSearch
86.10
22%
-106
- C2 -
3LV0
1
?
A:
[8-265]
-
S
A
V
M
N
V
M
V
Q
A
A
M
K
A
G
R
S
L
V
R
D
Y
G
E
V
QN
L
Q
V
S
L
-
K
G
P
A
D
Y
V
S
Q
A
D
R
K
A
E
K
I
I
F
N
E
L
S
K
A
R
P
K
F
G
F
L
M
E
E
---
S
E
E
I
--
I
-
G
-----
E
D
S
Q
H
-
R
F
I
V
D
P
L
D
G
T
T
N
F
L
H
G
I
P
F
F
A
V
S
I
A
L
E
S
Q
G
K
I
V
A
G
V
I
Y
-
N
P
I
N
D
E
L
-
F
T
A
E
R
G
S
G
A
F
F
N
D
R
R
----
C
-
R
V
S
A
R
R
R
L
E
D
C
V
I
---------
A
T
G
M
P
H
L
---
P
G
H
G
T
-
Y
----
L
I
E
--
L
R
N
V
M
A
--
E
V
S
------
G
I
R
R
F
G
T
A
A
L
D
L
A
Y
V
A
A
G
R
T
D
G
F
W
E
-
D
N
L
Q
I
W
D
M
A
A
G
I
L
M
V
R
E
A
G
G
F
V
T
D
K
E
G
G
N
D
I
F
--------
R
K
--
K
N
I
I
A
G
N
E
H
I
R
I
K
L
E
R
A
L
K
K
G