@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1032: (2015-12-05 )
MKIHYINDYKDIQAKEDCVLVLGYFDGLHLGHKALFDKAKKIATEKNLKIVVLTFNETPRLTFARFQPELLLHLTSPEKRSEKFQEYGVDELYLMNFTSHFSKVSSDLFIKKYIYGLRAKAAVVGFDYKFGHNRTSGDYLARNFKGPVYIIDEISEGGEKISSTRIRQLITEGNVEKANQLLGYEFSTCGMVVHGDARGRTIGFPTANLAPINRTYLPADGVYISNVLINGKYYRAMTSIGKNITFGGTELRLEANIFDFDGDIYGETIEIFWLKRIREMVKFNGIDDLVKQLKKDKEIALNWKKDSQTL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-......---70........80.......-.90........100.......110...-.-...120.......130...-..-..140..--..--...150.......160.......170.......180.-------......190.......-200........210....-...-..220...-------...-..-230----------...-----......240.....-..-250.......260-.......270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
H
Y
INDYKDIQAKE
D
C
V
L
V
L
G
YFD
G
L
H
L
G
H
K
A
L
F
D
K
A
K
K
IATEKN
L
K
I
V
V
L
TFNETP
R
L
T
F
-
A
RFQ
P
E
---
L
L
L
H
LTS
P
E
K
R
S
E
K
F
Q
E
YG-VD
E
L
Y
L
M
N
F
T
S
H
F
S
K
V
S
S
D
L
F
I
K
K
Y
I
Y
-G-LRA
K
A
A
V
V
G
F
D
Y
KFGHNRT-S
G
-
D
Y
L
A
R
NF--KG--
P
V
Y
I
I
D
E
I
SEGG
E
K
I
S
S
T
R
I
R
Q
L
I
TEG
N
V
E
K
A
N
Q
L
L
G
-------
Y
E
FST
C
G
M
V
V
HGDARG-
R
-
T
IGFPTANLA--PINR-TYL-PAD-
G
V
Y
I
-------
S
N
V
-
L
I-N------------
G
K
Y
-----
Y
R
A
M
T
SIGK
N
I
T
FG-G
T
-
E
L
R
L
E
A
N
I
F
DFDG-DIYG
E
T
I
E
I
F
W
L
K
R
I
R
E
M
V
KFN
G
I
D
D
L
V
K
Q
L
KKDK
E
I
A
L
N
WKKDSQTL-
1
PsiBlast_PDB
98.62
50%
-112
- C4 -
3OP1
10
?
A:
[10-307]
-----
I
K
N
Q
K
D
I
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
-
E
P
Y
H
P
D
---
L
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
-
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
T
Y
I
K
-
A
-
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
-
T
A
-
E
D
L
K
N
Y
F
--
D
G
--
E
V
I
I
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
-------
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
--
L
L
D
R
-
T
Y
M
-
P
A
D
-
G
V
Y
V
-------
V
D
V
-
E
I
-
Q
------------
R
Q
K
-----
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
----
E
A
R
F
E
V
N
I
F
D
F
N
Q
-
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
S
-------
25
HHSearch
96.73
52%
-110
- C4 -
3OP1
10
?
A:
[16-307]
-----------
I
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
-
E
---
P
Y
HPD
L
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
-
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
T
Y
I
K
-
A
-
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
--
T
A
E
D
L
K
N
Y
F
--
D
G
--
E
V
I
I
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
-------
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
--
L
L
D
R
-
T
Y
M
-
P
A
D
-
G
V
Y
V
-------
V
D
V
-
E
I
-
Q
------------
R
Q
K
-----
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
----
E
A
R
F
E
V
N
I
F
D
F
N
Q
-
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
S
-------
26
HHSearch
85.18
32%
-91
* C4 *
2X0K
3
RIBF_CORAM
A:
[1-322]
M
D
I
W
Y
G
T
A
A
-
V
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
-
L
---
P
R
R--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
-
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
-
G
T
A
D
S
L
R
Q
I
C
QS
R
L
--
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
-------
G
W
L
-
T
I
-
L
PTEAPVSGNMEP
E
V
A
-----
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
-
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
2
PsiBlast_PDB
83.99
31%
-101
- C4 -
4UZF
3
RIBF_CORAM
A:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
---
L
P
R
E
---
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
ILP
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
-----
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
4
PsiBlast_PDB
83.37
31%
-98
- C4 -
2X0K
3
RIBF_CORAM
A:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
ILP
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
-
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
23
PsiBlast_CBE
83.12
31%
-96
- C4 -
2X0K
3
RIBF_CORAM
B:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
RL
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
GWLTILP
T
E
A
-
P
V
-
S
------------
G
N
M
EPEVA
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
-
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
3
PsiBlast_PDB
82.46
31%
-97
- C4 -
4UZE
3
RIBF_CORAM
A:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
-
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
5
PsiBlast_PDB
81.67
31%
-98
- C4 -
3ZUG
3
RIBF_CORAM
A:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
D
E
-
Q
R
S
V
D
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
22
PsiBlast_CBE
81.09
31%
-100
- C4 -
4UZE
3
RIBF_CORAM
B:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
ILP
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
----
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
21
PsiBlast_CBE
81.06
31%
-105
- C4 -
4UZF
3
RIBF_CORAM
B:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
---
L
P
R
E
---
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
--
Q
S
RL
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
ILP
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
----
E
-
Q
R
S
V
E
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
10
PsiBlast_PDB
79.70
30%
-115
- C4 -
1S4M
2
?
A:
[1-283]
-----------------
M
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
-----
F
L
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
-
V
--
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
-
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
-
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
P
T
--D
A
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
6
PsiBlast_PDB
79.67
30%
-112
- C4 -
1MRZ
1
?
A:
[2-283]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
-----
F
L
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
-
V
--
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
-
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
-
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
24
PsiBlast_CBE
79.06
31%
-101
- C4 -
3ZUG
3
RIBF_CORAM
B:
[15-310]
---------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
P
------
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
-
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
-
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
-
D
S
L
R
Q
I
C
----L-
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
-------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
--G
K
-
E
L
G
F
P
T
A
N
Q
Y
--
F
H
D
T
-
V
A
L
-
P
A
D
-
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
-
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
----
E
-
Q
R
S
V
D
S
F
V
L
D
R
D
A
-
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
A
-
27
HHSearch
78.73
30%
-114
- C4 -
1MRZ
1
?
A:
[2-284]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
-
P
---
D
----
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
--
S
--
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
A
S
F
L
R
K
K
---
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
--
R
G
N
E
K
L
V
D
-
L
K
R
-
G
V
Y
L
-------
V
R
V
-
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
-------R
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
7
PsiBlast_PDB
78.05
30%
-106
- C4 -
1T6X
1
?
A:
[2-283]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
-----
F
L
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
-
V
--
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
-
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
-
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
9
PsiBlast_PDB
77.52
30%
-104
- C4 -
1T6Z
1
?
A:
[2-283]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
-----
F
L
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
-
V
--
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
-
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
-
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
8
PsiBlast_PDB
77.45
30%
-103
- C4 -
1T6Y
3
?
A:
[2-283]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
-----
F
L
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
---
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
-
V
--
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
-
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
-
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
-
47
Fugue
77.15
30%
-102
- C4 -
1MRZ
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
-----
P
D
---
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
-
R
T
V
V
L
D
---
F
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-
G
---
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
-
G
N
-
A
S
F
L
R
K
K
--
G
V
--
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
-------
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
--
R
G
N
E
-
K
L
V
D
L
K
R
-
G
V
Y
L
-------
V
R
V
-
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
R
N
-------
V
K
Y
E
V
Y
I
L
D
F
E
G
-
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
12
PsiBlast_PDB
51.07
28%
-105
- C4 -
1N05
-
RIFK_SCHPO
A:
[10-145]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
I
V
G
P
EKVQSP
Y
P
I
R
F
E
G
K
V
V
H
G
F
G
R
G
S
K
-
E
L
G
I
P
T
A
N
I
S
ED
A
I
Q
E
-
L
L
R
-
Y
R
D
S
G
V
Y
F
-------
G
Y
A
-
M
V
-
Q
------------
K
R
V
-----
F
P
M
V
M
S
V
-------------
S
A
E
V
H
L
I
E
R
Q
G
E
D
F
Y
E
E
I
M
R
V
I
V
L
G
Y
I
R
P
E
L
N
Y
A
G
L
D
K
L
I
E
D
I
H
T
D
I
R
V
A
L
N
S
M
D
R
P
S
Y
S
-
41
HHSearch
50.13
25%
-86
- C4 -
1COZ
1
TAGD_BACSU
A:
[1-126]
---------------
M
K
K
V
I
T
Y
G
T
F
D
L
L
H
W
G
H
I
K
L
L
E
R
A
K
Q
L
G
---
D
Y
L
V
V
A
I
S
T
D
E
F
N
L
Q
-
K
-----
Q
-----
K
K
A
Y
H
S
Y
E
H
R
K
L
I
L
E
T
I
R
Y
V
D
E
V
I
P
E
--------
K
N
W
E
Q
K
K
Q
D
I
I
--
D
-
H
N
I
D
V
F
V
M
G
D
D
W
E
G
K
F
-------
D
F
L
K
D
----
Q
C
--
E
V
V
Y
L
P
R
----
T
E
G
I
S
T
T
K
I
K
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------