@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1089: (2015-12-05 )
MKTDIEIAQSVALKPIAEIVEQVGIGFDDIELYGKYKAKLSFDKIEAVRSQKVGKLILVTAINPTPAGEGKSTMSIGLADALNKIGKKTMIALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALLDNHIHQGNELDIDQRRVIWKRVVDLNDRALRQVIVGLGSSVNGIPREDGFDITVASEIMAILCLATDLSDLKKRLSNIVVAYSRDRKPIYVKDLKIEGALTLILKDAIKPNLVQTIYGTPALVHGGPFANIAHGCNSVLATSTALRLADYVVTEAGFGADLGAEKFLDIKTPNLPTSPDAIVIVATLRALKMHGGVSKEDLSQENVKAVKRGFTNLERHVNNMRQYGVPVVVAINQFTADTESEIATLKTLCSNIDVAVELASVWEDGADGGLELAQTVANVIETQSSNYKRLYNDEDTIEEKIKKIVTKIYGGNKVHFGPKAQIQLKEFSDNGWDKMPICMAKTQYSFSDNPNLLGAPTDFDITVREFVPKTGAGFIVALTGDVLTMPGLPKKPAALNMDVLEDGTAIGLF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKT
D
I
E
I
A
Q
S
V
A
L
K
P
I
A
E
I
V
E
Q
VGIG
F
D
D
I
E
L
Y
G
K
Y
K
AKLS
F
D
K
I
E
A
V
R
SQKV
G
K
L
I
L
V
T
AINPTPAGEGK
S
T
M
S
I
G
L
A
D
A
L
N
KIGK
K
T
M
I
A
LREPSLGPVMGIKGGAAGGG
Y
A
Q
V
L
P
ME
D
I
N
L
H
FTGD
M
H
A
I
TT
A
N
N
A
L
S
A
L
L
D
N
HIHQGNEL
D
I
D
Q
R
R
V
I
W
K
R
V
VDL
N
D
R
A
L
R
Q
V
I
V
GLGSSVNGIPREDGF
D
I
T
V
A
S
E
I
M
A
I
L
C
LAT
D
L
S
D
L
K
K
R
L
S
N
I
V
V
A
YSRDRK
P
I
Y
V
K
D
L
KIE
G
A
L
T
L
I
L
K
DAIK
P
N
L
V
Q
T
IYGTPALVHGGP
F
A
N
I
A
H
G
C
N
S
V
L
A
T
S
T
A
L
R
L
A
D
Y
V
VTEAGFGADLGAE
K
F
L
DIKTPNLPTSP
D
A
I
V
I
V
A
T
L
R
A
L
K
MHGGV
S
K
E
D
L
S
Q
E
N
V
K
A
V
K
R
G
F
T
N
L
E
R
H
V
N
N
M
R
Q
YGV
P
V
V
V
A
I
NQFTAD
T
E
S
E
I
A
T
L
K
T
L
CSNI
D
V
A
V
E
L
A
S
V
W
EDGAD
G
G
L
E
L
A
Q
T
V
A
N
V
I
E
TQSSN
Y
K
R
LYND
E
D
T
I
E
E
K
I
K
K
I
V
T
K
IYGGN
K
V
H
FGPK
A
Q
I
Q
L
K
EFSDNGWDKM
P
I
C
M
A
K
T
QYSFSDNPNLLGAPTDF
D
I
T
V
R
E
FVPKTGA
G
F
I
V
A
LTG
D
V
LTMPGLPKKPAALN
M
D
VLEDGTAIGLF
1
PsiBlast_PDB
99.20
59%
-97
- C1 -
4JIM
8
FTHS_MOOTH
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
5
PsiBlast_PDB
98.92
59%
-96
- C1 -
4IOJ
6
FTHS_MOOTA
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
6
PsiBlast_PDB
98.90
59%
-94
- C1 -
4IOK
7
FTHS_MOOTA
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
20
PsiBlast_CBE
98.67
59%
-96
- C1 -
4JIM
5
FTHS_MOOTH
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
17
PsiBlast_CBE
98.29
59%
-97
- C1 -
4JKI
2
FTHS_MOOTH
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
8
PsiBlast_PDB
97.91
59%
-95
- C1 -
4IOM
9
FTHS_MOOTA
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
7
PsiBlast_PDB
97.84
59%
-93
- C1 -
4IOL
4
FTHS_MOOTA
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
2
PsiBlast_PDB
97.80
59%
-95
- C1 -
4JJK
11
FTHS_MOOTH
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
24
PsiBlast_CBE
97.76
59%
-94
- C1 -
4IOJ
5
FTHS_MOOTA
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
19
PsiBlast_CBE
97.70
59%
-94
- C1 -
4JJK
4
FTHS_MOOTH
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
23
PsiBlast_CBE
97.45
59%
-93
- C1 -
4IOK
6
FTHS_MOOTA
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
4
PsiBlast_PDB
97.42
59%
-95
- C1 -
4JKI
6
FTHS_MOOTH
A:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
21
PsiBlast_CBE
97.40
59%
-95
- C1 -
4IOM
4
FTHS_MOOTA
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
3
PsiBlast_PDB
97.20
59%
-93
- C1 -
4JJZ
6
FTHS_MOOTH
A:
[6-558]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
-
11
PsiBlast_PDB
96.93
58%
-92
- C1 -
3QUS
8
FTHS_MOOTH
A:
[6-555]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
--
A
G
A
E
V
A
L
S
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
G
R
L
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
--
22
PsiBlast_CBE
96.79
59%
-96
- C1 -
4IOL
3
FTHS_MOOTA
B:
[6-559]
--
S
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
F
18
PsiBlast_CBE
95.73
59%
-92
- C1 -
4JJZ
7
FTHS_MOOTH
B:
[7-558]
---
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
A
G
A
E
V
A
L
S
E
V
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
A
G
F
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
L
-
30
Fugue
95.30
58%
-93
- C1 -
1EG7
7
FTHS_MOOTH
A:
[7-555]
---
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
E
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
K
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
--
A
G
A
E
V
A
L
S
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
G
R
L
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
--
12
PsiBlast_PDB
95.30
58%
-93
- C1 -
1EG7
7
FTHS_MOOTH
A:
[7-555]
---
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
E
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
K
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
--
A
G
A
E
V
A
L
S
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
G
R
L
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
--
25
PsiBlast_CBE
95.05
58%
-90
- C1 -
3QUS
5
FTHS_MOOTH
B:
[7-555]
---
D
I
E
I
A
Q
A
A
K
M
K
P
V
M
E
L
A
R
G
L
G
I
Q
E
D
E
V
E
L
Y
G
K
Y
K
A
K
I
S
L
D
V
Y
R
R
L
K
D
K
P
D
G
K
L
I
L
V
T
A
I
T
P
T
P
A
G
E
G
K
T
T
T
S
V
G
L
T
D
A
L
A
R
L
G
K
R
V
M
V
C
L
R
E
P
S
L
G
P
S
F
G
I
K
G
G
A
A
G
G
G
Y
A
Q
V
V
P
M
E
D
I
N
L
H
F
T
G
D
I
H
A
V
T
Y
A
H
N
L
L
A
A
M
V
D
N
H
L
Q
Q
G
N
V
L
N
I
D
P
R
T
I
T
W
R
R
V
I
D
L
N
D
R
A
L
R
N
I
V
I
G
L
G
G
K
A
N
G
V
P
R
E
T
G
F
D
I
S
V
A
S
E
V
M
A
C
L
C
L
A
S
D
L
M
D
L
K
E
R
F
S
R
I
V
V
G
Y
T
Y
D
G
K
P
V
T
A
G
D
L
E
A
Q
G
S
M
A
L
L
M
K
D
A
I
K
P
N
L
V
Q
T
L
E
N
T
P
A
F
I
H
G
G
P
F
A
N
I
A
H
G
C
N
S
I
I
A
T
K
T
A
L
K
L
A
D
Y
V
V
T
E
A
G
F
G
A
D
L
G
A
E
K
F
Y
D
V
K
C
R
Y
A
G
F
K
P
D
A
T
V
I
V
A
T
V
R
A
L
K
M
H
G
G
V
P
K
S
D
L
A
T
E
N
L
E
A
L
R
E
G
F
A
N
L
E
K
H
I
E
N
I
G
K
F
G
V
P
A
V
V
A
I
N
A
F
P
T
D
T
E
A
E
L
N
L
L
Y
E
L
C
A
K
--
A
G
A
E
V
A
L
S
W
A
K
G
G
E
G
G
L
E
L
A
R
K
V
L
Q
T
L
E
S
R
P
S
N
F
H
V
L
Y
N
L
D
L
S
I
K
D
K
I
A
K
I
A
T
E
I
Y
G
A
D
G
V
N
Y
T
A
E
A
D
K
A
I
Q
R
Y
E
S
L
G
Y
G
N
L
P
V
V
M
A
K
T
Q
Y
S
F
S
D
D
M
T
K
L
G
R
P
R
N
F
T
I
T
V
R
E
V
R
L
S
A
G
G
R
L
I
V
P
I
T
G
A
I
M
T
M
P
G
L
P
K
R
P
A
A
C
N
I
D
I
D
A
D
G
V
I
T
G
--