@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1115: (2015-12-05 )
MSLFQEKIAYNCAKKEALYKESLGRYALRSMLAGAYLTMSTAAGIVAADTIGKISPALSGFVFAFIFSFGLIYVLIFNGELATSNMLYLTAGAYNKNISWKKAITILIYCTFFNLVGACILAWLFNQSYSFQHLTNDSFLGHVVAKKLGKPSSGAFLEGIIANMFVNLAILAYMLLKEESAKMTVILSAIFMFVFLSNEHLIANFASFMLAAFSHIEHIKGFTLLNVIRQWTLVFFGNWIGGGVFIGLAYAWLNKTKTSHHE
Atome Classification :
(20 SA)
.........10........20........30---.........40........50...-----.....60........70........80........90........100.......110......---.120......--.130--.-......140---........150......----.160.......170.......-180.......190.......200..------------.--------------..--..210....--------------..--------------.220....-...230..-......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
L
F
Q
E
K
I
A
Y
NC
A
K
K
E
A
L
Y
K
E
S
L
G
R
Y
A
L
R
S
----
M
LAG
A
Y
L
T
M
STAA
G
I
V
A
A
D
T
IG
K
I
-----
S
P
A
L
S
G
F
V
F
A
F
I
F
S
F
G
L
I
Y
V
L
I
FNGELATS
N
M
L
Y
L
TAGAYNKNISW
K
K
A
I
T
I
L
I
Y
C
T
F
F
N
L
V
G
A
---
C
I
L
A
W
L
FNQS--YS
F
Q
--H-LTND
S
F
L
G
----
H
V
V
A
K
KLGKPSS
G
A
F
L
E
----
G
I
I
A
N
M
F
V
N
L
A
I
L
A
Y
M
L
L
KEE-SA
K
M
T
V
I
L
S
A
I
F
M
F
V
FLSN
E
H
L
I
A
N
------------
F
--------------
A
S
--
F
M
L
A
A
F
S
H
I
--------------
E
H
--------------IK
G
F
T
L
L
N
-
V
I
R
Q
-
W
T
L
-
V
F
FGNWIG
G
G
V
F
I
G
L
A
Y
A
W
L
NKTKTSHHE
9
PsiBlast_PDB
94.38
29%
-139
- C4 -
4FC4
-
?
A:
[7-249]
-----
N
K
C
A
A
N
A
A
R
I
A
R
L
S
A
N
N
P
L
G
F
W
V
S
S
----
A
M
A
G
A
Y
V
G
L
----
G
I
I
L
I
F
T
L
G
N
L
L----
D
P
S
V
R
P
L
V
M
G
A
T
F
G
I
A
L
T
L
V
I
I
A
G
S
E
L
F
T
G
H
T
M
F
L
T
L
G
V
K
A
G
T
I
S
H
G
Q
M
W
A
I
L
P
Q
T
W
L
G
N
L
V
G
S
---
V
F
V
A
L
L
Y
S
W
G
--
G
G
S
L
--
L
-
P
V
D
T
S
I
V
H
----
S
V
A
L
A
K
T
T
A
P
A
T
V
L
F
F
K
----
G
A
L
C
N
W
L
V
C
L
A
I
--
W
M
A
I
R
T
E
G
T
A
K
F
L
A
I
W
W
C
L
L
A
F
I
A
S
G
Y
E
H
S
V
A
N
------------
M
--------------
T
L
--
F
A
L
S
W
F
G
H
----------------
H
--------------
S
D
A
Y
T
L
A
G
-
I
G
H
N
-
L
L
W
-
V
T
L
G
N
T
L
S
G
V
V
F
M
G
L
G
Y
-
W
Y
A
T
-------
5
PsiBlast_PDB
91.96
28%
-137
- C4 -
3TE0
1
?
A:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
E
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
37
Fugue
91.79
25%
-146
- C4 -
3KCU
1
FOCA_ECO57
A:
[29-280]
--------------------
K
H
P
L
K
T
F
Y
L
A
----
I
T
A
G
V
F
I
S
I
A
F
V
F
Y
I
T
A
T
T
G
T
G
T
M
-----
P
F
G
M
A
K
L
V
G
G
I
C
F
S
L
G
L
I
L
C
V
V
C
G
A
D
L
F
T
S
T
V
L
I
V
V
A
K
A
-
S
G
R
I
T
W
G
Q
L
A
K
N
W
L
N
V
Y
F
G
N
L
V
G
A
---
L
L
F
V
L
L
M
W
L
S
GE
Y
M
T
A
--
N
-
G
Q
W
G
L
N
V
L
----
Q
T
A
D
H
K
V
H
H
T
F
I
E
A
V
C
L
----
G
I
L
A
N
L
M
V
C
L
A
V
W
M
S
Y
S
G
R
S
L
-
M
D
K
A
F
I
M
V
L
P
V
A
M
F
V
A
S
G
F
E
H
S
I
A
N
------------
M
--------------
F
M
--
I
P
M
G
I
V
I
R
D
F
AS
P
E
F
W
T
A
V
GSAP
E
N
--------------
F
S
H
L
T
V
M
N
-
F
I
T
D
N
L
I
P
-
V
T
I
G
N
I
I
G
G
G
L
L
V
G
L
T
Y
W
V
I
Y
L
R
------
27
HHSearch
91.13
25%
-137
- C4 -
3KLY
4
?
A:
[22-278]
-----------
G
E
G
K
---
A
K
K
A
A
Y
K
S
F
L
L
A
----
I
S
A
G
I
Q
I
G
I
A
F
V
F
Y
T
V
V
T
T
G
A
H
D
M
-----
P
Y
G
V
T
K
L
L
G
G
L
A
F
S
L
G
L
I
L
V
V
I
T
G
G
E
L
F
T
S
S
V
L
I
L
-
V
A
K
A
S
G
K
I
S
W
K
E
L
V
R
N
W
T
V
V
Y
F
G
N
L
C
G
S
---
I
I
L
V
F
I
M
L
A
T
--
R
Q
F
M
ED
G
-
G
Q
L
G
L
N
A
M
----
A
I
S
Q
H
K
L
H
H
T
F
L
Q
A
F
A
L
----
G
L
M
C
N
I
L
V
C
L
A
V
W
M
T
F
S
A
R
S
L
-
T
D
K
V
M
V
L
I
L
P
V
A
M
F
V
S
S
G
F
E
H
C
I
A
N
------------
M
--------------
F
Q
--
V
P
M
A
I
G
I
K
Y
--------------
F
A
P
E
S
F
W
A
M
T
GANIAQ
Y
A
D
L
N
F
V
N
F
I
V
N
N
-
L
I
P
-
V
T
L
G
N
I
V
G
G
G
V
F
V
G
M
W
Y
W
L
I
Y
L
-------
1
PsiBlast_PDB
91.08
28%
-137
- C4 -
3TDO
5
?
A:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
4
PsiBlast_PDB
89.60
28%
-139
- C4 -
3TDX
4
?
A:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
V
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
7
PsiBlast_PDB
89.38
28%
-138
- C4 -
3TE1
3
?
A:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
A
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
26
HHSearch
89.25
23%
-142
- C4 -
3KCU
1
FOCA_ECO57
A:
[29-280]
--------------------
K
H
P
L
K
T
F
Y
L
A
----
I
T
A
G
V
F
I
S
I
A
F
V
F
Y
I
T
A
T
T
G
T
G
T
M
-----
P
F
G
M
A
K
L
V
G
G
I
C
F
S
L
G
L
I
L
C
V
V
C
G
A
D
L
F
T
S
T
V
L
I
-
V
V
A
K
A
S
G
R
I
T
W
G
Q
L
A
K
N
W
L
N
V
Y
F
G
N
L
V
G
A
---
L
L
F
V
L
L
M
W
L
S
--
G
E
Y
M
T-
A
N
G
Q
W
G
L
N
V
L
----
Q
T
A
D
H
K
V
H
H
T
F
I
E
A
V
C
L
----
G
I
L
A
N
L
M
V
C
L
A
V
W
M
S
Y
S
G
R
S
L
-
M
D
K
A
F
I
M
V
L
P
V
A
M
F
V
A
S
G
F
E
H
S
I
A
N
------------
M
--------------
F
M
--
I
P
M
G
I
V
I
R
D
--------------
F
A
S
P
E
F
W
T
A
V
GSAPEN
F
S
H
L
T
V
M
N
F
I
T
D
N
-
L
I
P
-
V
T
I
G
N
I
I
G
G
G
L
L
V
G
L
T
Y
W
V
I
Y
L
R
------
8
PsiBlast_PDB
88.58
28%
-135
- C4 -
3TDS
3
?
E:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
LTDAG
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
I
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
3
PsiBlast_PDB
88.05
28%
-137
- C4 -
3TDP
2
?
A:
[8-257]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
25
HHSearch
87.53
25%
-133
* C4 *
3TDS
3
?
E:
[7-259]
--
E
T
L
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
-----
G
S
P
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
I
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
P
T
--------------
I
----------------
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
2
PsiBlast_PDB
86.68
28%
-130
- C4 -
3TDR
-
?
A:
[10-259]
-----
D
K
L
T
N
A
A
I
N
K
I
N
L
L
N
T
S
K
V
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
6
PsiBlast_PDB
85.43
28%
-149
- C4 -
3TE2
5
?
A:
[29-259]
------------------------
K
Y
L
V
S
S
----
A
F
A
G
L
Y
V
G
I
----
G
I
L
L
I
F
T
I
G
G
L
L
T
D
A
G
S
P
-
M
T
K
I
V
M
G
L
S
F
A
I
A
L
S
L
V
I
M
T
G
T
E
L
F
T
G
N
N
M
V
M
S
A
G
M
L
N
K
G
V
S
I
K
D
T
S
K
I
W
A
Y
S
W
V
G
N
L
I
G
A
---
L
V
L
G
I
I
F
V
G
T
--
G
L
V
D
--
K
-
G
P
V
A
E
F
F
A
----
N
T
A
A
S
K
A
S
M
P
F
T
A
L
F
F
R
----
G
I
L
C
N
I
L
V
C
V
S
V
L
C
S
F
R
T
N
S
D
-
T
A
K
I
I
M
I
F
L
C
L
F
A
F
I
T
S
G
F
E
H
S
V
A
N
------------
M
--------------
T
I
--
Y
S
V
S
L
F
S
----------------
P
T
--------------
I
S
T
V
T
I
G
G
-
A
I
Y
N
-
L
V
A
-
V
T
L
G
N
I
V
G
G
A
L
F
M
G
L
G
T
Y
I
L
G
K
E
K
-----
12
PsiBlast_PDB
79.50
27%
-142
- C4 -
3KCU
1
FOCA_ECO57
A:
[29-280]
------------------------
K
H
P
L
K
T
F
Y
L
A
I
T
A
G
V
F
I
S
I
A
F
V
F
Y
I
T
A
T
T
G
T
G
T
M
-----
P
F
G
M
A
K
L
V
G
G
I
C
F
S
L
G
L
I
L
C
V
V
C
G
A
D
L
F
T
S
T
V
L
I
V
V
A
K
A
S
G
R
-
I
T
W
G
Q
L
A
K
N
W
L
N
V
Y
F
G
N
L
V
G
A
L
L
F
V
L
L
M
W
L
-------
S
G
E
--
Y
-
M
T
A
N
G
Q
W
G
----
L
N
V
L
Q
T
A
D
H
K
V
H
H
T
F
I
E
A
V
C
L
G
I
L
A
N
L
M
V
C
L
A
V
W
M
S
Y
S
G
R
S
L
-
M
D
K
A
F
I
M
V
L
P
V
A
M
F
V
A
S
G
F
E
H
S
I
A
N
M
F
M
I
P
M
G
I
V
I
R
D
F
--------------
A
S
P
E
F
W
T
A
V
G
S
A
P
--------------
E
N
--------------
F
S
H
L
T
V
M
N
-
F
I
T
D
-
N
L
I
P
V
T
I
G
N
I
I
G
G
G
L
L
V
G
L
T
Y
W
V
I
Y
L
R
------
13
PsiBlast_PDB
79.30
27%
-144
- C4 -
3KCV
-
FOCA_ECO57
A:
[30-279]
-------------------------
H
P
L
K
T
F
Y
L
A
I
T
A
G
V
F
I
S
I
A
F
V
F
Y
I
T
A
T
T
G
T
G
T
M
-----
P
F
G
M
A
K
L
V
G
G
I
C
F
S
L
G
L
I
L
C
V
V
C
G
A
D
L
F
T
S
T
V
L
I
V
V
A
K
A
S
G
R
-
I
T
W
G
Q
L
A
K
N
W
L
N
V
Y
F
G
N
L
V
G
A
L
L
F
V
L
L
M
W
L
-------
S
G
E
--
Y
-
M
T
A
N
G
Q
W
G
----
L
N
V
L
Q
T
A
D
H
K
V
H
H
T
F
I
E
A
V
C
L
G
I
L
A
N
L
M
V
C
L
A
V
W
M
S
Y
S
G
R
S
L
-
M
D
K
A
F
I
M
V
L
P
V
A
M
F
V
A
S
G
F
E
H
S
I
A
N
M
F
M
I
P
M
G
I
V
I
R
D
F
--------------
A
S
P
E
F
W
T
A
V
G
S
A
P
--------------
E
N
--------------
F
S
H
L
T
V
M
N
-
F
I
T
D
-
N
L
I
P
V
T
I
G
N
I
I
G
G
G
L
L
V
G
L
T
Y
W
V
I
Y
L
-------
14
PsiBlast_PDB
75.53
26%
-135
- C4 -
3Q7K
1
?
A:
[19-274]
------------
A
E
E
A
G
V
Y
K
A
T
--
K
H
P
L
K
T
F
Y
L
A
I
T
A
G
V
F
I
S
I
A
F
V
F
Y
I
T
A
T
T
G
T
G
A
M
-----
P
Y
G
M
A
K
L
I
G
G
I
C
F
S
L
G
L
I
L
C
V
I
C
G
A
D
L
F
T
S
T
V
L
I
V
V
A
K
A
S
G
R
-
I
T
W
G
Q
L
A
K
N
W
L
N
V
Y
F
G
N
L
I
G
A
L
L
F
V
L
L
M
W
L
-------
S
G
E
--
Y
-
M
T
A
N
G
Q
W
G
----
L
N
V
L
Q
T
A
D
H
K
M
H
H
T
F
I
E
A
V
C
L
G
I
L
A
N
L
M
V
C
L
A
V
W
M
S
Y
S
G
R
S
L
-
M
D
K
A
F
I
M
V
L
P
V
A
M
F
V
A
S
G
F
E
H
S
I
A
N
------------
M
F
M
I
P
M
G
I
V
I
R
D
FAT
P
E
--
F
W
T
A
V
G
S
S
P
--------------
E
S
--------------
F
S
H
L
T
V
M
S
-
F
I
T
D
-
N
L
I
P
V
T
I
G
N
I
I
G
G
G
L
L
V
G
L
T
Y
------------
11
PsiBlast_PDB
72.07
31%
-138
- C4 -
3KLZ
12
?
A:
[74-275]
---------------------------------------------------------------------------
F
S
L
G
L
I
L
V
V
I
T
G
G
E
L
F
T
S
S
V
L
I
L
V
A
K
A
S
G
K
-
I
S
W
K
E
L
V
R
N
W
T
V
V
Y
F
G
N
L
C
G
S
---
I
I
L
V
F
I
M
L
A
T
--
R
Q
F
-----
M
E
D
G
G
Q
L
G
L
N
A
M
A
I
S
Q
H
K
L
H
H
T
F
L
Q
A
F
A
L
----
G
L
M
C
N
I
L
V
C
L
A
V
W
M
T
F
S
A
R
S
L
-
T
D
K
V
M
V
L
I
L
P
V
A
M
F
V
S
S
G
F
E
H
C
I
A
N
------------
M
F
Q
V
P
M
A
I
G
I
K
Y
FAP
E
S
--
F
W
A
M
T
G
A
N
I
--------------
A
Q
--------------
Y
A
D
L
N
F
V
N
F
I
V
N
N
-
L
I
P
-
V
T
L
G
N
I
V
G
G
G
V
F
V
G
M
W
Y
-
W
L
I
Y
L
------
18
PsiBlast_CBE
71.22
31%
-135
- C4 -
3KLZ
8
?
D:
[74-275]
---------------------------------------------------------------------------
F
S
L
G
L
I
L
V
V
I
T
G
G
E
L
F
T
S
S
V
L
I
L
V
A
K
A
S
G
K
-
I
S
W
K
E
L
V
R
N
W
T
V
V
Y
F
G
N
L
C
G
S
---
I
I
L
V
F
I
M
L
A
T
--
R
Q
F
-----
M
E
D
G
G
Q
L
G
LNAM
A
I
S
Q
H
K
L
H
H
T
F
L
Q
A
F
A
L
----
G
L
M
C
N
I
L
V
C
L
A
V
W
M
T
F
S
A
R
S
L
-
T
D
K
V
M
V
L
I
L
P
V
A
M
F
V
S
S
G
F
E
H
C
I
A
N
------------
M
FQVPMAIGIKYFAP
E
S
--
F
W
A
M
T
G
A
N
I
--------------
A
Q
--------------
Y
A
D
L
N
F
V
N
F
I
V
N
N
-
L
I
P
-
V
T
L
G
N
I
V
G
G
G
V
F
V
G
M
W
Y
-
W
L
I
Y
L
K
-----
10
PsiBlast_PDB
68.80
31%
-129
- C4 -
3KLY
4
?
A:
[74-275]
---------------------------------------------------------------------------
F
S
L
G
L
I
L
V
V
I
T
G
G
E
L
F
T
S
S
V
L
I
L
V
A
K
A
S
G
K
-
I
S
W
K
E
L
V
R
N
W
T
V
V
Y
F
G
N
L
C
G
S
---
I
I
L
V
F
I
M
L
A
T
--
R
Q
F
-----
M
E
D
G
G
Q
L
G
L
N
A
M
A
I
S
Q
H
K
L
H
H
T
F
L
Q
A
F
A
L
----
G
L
M
C
N
I
L
V
C
L
A
V
W
M
T
F
S
A
R
S
L
-
T
D
K
V
M
V
L
I
L
P
V
A
M
F
V
S
S
G
F
E
H
C
I
A
N
------------
M
F
Q
V
P
M
A
I
G
I
K
Y
FAP
E
S
--
F
W
A
M
T
G
A
N
I
--------------
A
Q
--------------
Y
A
D
L
N
F
V
N
F
I
V
N
N
-
L
I
P
-
V
T
L
G
N
I
V
G
G
G
V
F
V
G
M
W
Y
-
W
L
I
Y
L
------
24
PsiBlast_CBE
67.67
31%
-131
- C4 -
3KLY
7
?
B:
[74-275]
---------------------------------------------------------------------------
F
S
L
G
L
I
L
V
V
I
T
G
G
E
L
F
T
S
S
V
L
I
L
V
A
K
A
S
G
K
-
I
S
W
K
E
L
V
R
N
W
T
V
V
Y
F
G
N
L
C
G
S
---
I
I
L
V
F
I
M
L
A
T
--
R
Q
F
-----
M
E
D
G
G
Q
L
G
L
N
A
M
A
I
S
Q
H
K
L
H
H
T
F
L
Q
A
F
A
L
----
G
L
M
C
N
I
L
V
C
L
A
V
W
M
T
F
S
A
R
S
L
-
T
D
K
V
M
V
L
I
L
P
V
A
M
F
V
S
S
G
F
E
H
C
I
A
N
------------
M
F
Q
V
P
M
A
I
G
I
K
Y
F
AP
E
S
--
F
W
A
M
T
G
A
N
I
--------------
A
Q
--------------
Y
A
D
L
N
F
V
N
F
I
V
N
N
-
L
I
P
-
V
T
L
G
N
I
V
G
G
G
V
F
V
G
M
W
Y
-
W
L
I
Y
L
------