@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1128: (2015-12-05 )
MELKRKRLLPYLLLSLLLAYLTHRAYVLYCMAPQADMTNLFAPYTYVFEKITEPPYFYWNTSPLAILSALVGFFVGLLFYLKIRLDGNYRHGEESGSACFATAQELKGFQDEESRNNMIFSREAQMGLFNKRLPFERQLNKNVLVAGLPGDGKTYTYVKPNLMQMNSSFIVTDPKGLLVREVGTMLKENGYQIKIFDLVNLTNSDMFNPFRYMRSELDIDRITEAIVEGTKKGDREGEDFWNQAKLLLNRALLGYLYFDSQVRHYEPNLSMVADLLRNLKRPNEKELSAVEKMFKQLEEKLPGNYACRQWELFNSNFEAETRTGVLSIVATQYSIFDHDAVTNLIKTDTMEMDTWNTEKTAVFVAISETNKAYSFLASTFFTVVFDQLTHSADAIIQGEKKGYELKDLLHVQFYFDEFANCGKIPHFNEVLASIRSREMSIKIIIQAISQLDSLYGVPARKSMVNNCATLLFLGTNDEDTMKYFSMRAGKQTIIQTSYSEQRGHRISGTTSRQAHQRDLMTPDEIARIGVDEALVFISKQNVFRDKKAMVSNHPMKDRLANHYQDKTWYHYKRFMEEGAEFIDAVMTGQIPEDRIWAPDMSDYQAFLEENGFDNTRQSAPETSVHNQVPVTNPEMPSESPSQTSETSKKLVDMDTGEIFELPPEDREGFGEVSFDDQRVEI
Atome Classification :
(20 SA)
----.........10........20....-----...-.30..-......40......-..50......------------------------..60.......-.70...-.....80........90........100.-------------......110.......120-.....----.-----------------.130-.......140......-.-150.....--..-----160----------..---......---170.......180.-.....-.190---.......200...-------------....-210----------........220.......230.......240------.....---------------------------------------....250-.......260....-----------...270.--.......280.......290--........-.300--------...--.--..-...310.......320......---.330.......340----------------...--....350.---......--.360...-----------..-.---..-370.......380.......390.......400.......410....-....420.-------.------....-.430.......440.......450.......460.......470-...-..--.--...480.......490.......500.......510.......520.--......530.---......540.......550.......560--------..-......570.......580.......590.......600-......-------.610.......620.......630--........640.......650.......660.......670.------.....--.680------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----ME
L
K
R
K
R
L
L
P
Y
L
L
L
S
L
L
L
A
Y
L
THR
A
-----
Y
V
L
-
Y
C
MAP-QA
D
M
T
N
LF
A
P
Y
T
Y
V
-
F
E
K
ITEP
P
Y
F
------------------------
Y
WNT
S
P
L
A
I
L
S
-
A
L
V
G
F
F
-
V
G
L
L
F
Y
L
K
I
R
LDGNYRHGEESG
S
A
C
F
A
T
A
-------------
Q
E
LKGFQDEESRN
N
M
I
F
SR-EAQMG----L-----------------FNKR-L
P
F
E
R
QLNK
N
V
L
V
AGL-P-GDG
K
T
Y
T
Y
--VK-----
P
N
-----------
L
M---QMNS
S
F
---
I
V
TDPK
G
L
L
V
R
E
V
G
-
T
M
L
KE-NG
Y
Q
---
I
K
I
F
D
L
V
NLTNSD-------------MF
N
P
-
F
R
-----------
Y
M
R
S
EL
D
I
D
R
I
T
E
A
I
V
EGTKKGDRE
G
E
D
F
--------
W
N
Q
A
K
---------------------------------------
L
L
L
N
R
A
L
-
L
G
Y
L
Y
FDSQVRHYE-----------P
N
L
S
-
M
V
--
A
D
L
L
R
N
LKRP
N
E
K
E
L
S
A
V
----
E
K
M
F
K
Q
L
E
-
E
K----------LPG--N--YA-
C
R
Q
W
E
LFNSNFEAETRT
G
V
L
S
I
---
V
A
T
Q
Y
SIF
D
H
D
A
V
T
----------------
N
L
I
--KTD
T
M
E-M---DTWNTE--
K
T
A
-
V
F
V
-----------
A
I-S---ET-
N
K
A
Y
S
F
L
A
S
T
F
F
T
V
V
F
D
Q
LTHS
A
D
A
I
I
QGEKKGY
E
L
K
D
L
L
H
-
V
Q
F
Y
F
-
D
E
FANCGK-------I------P
H
F
N
-
E
V
L
A
S
I
R
SRE
M
S
I
K
I
I
I
Q
A
I
S
Q
L
D
S
L
YGV
P
A
R
K
S
M
V
NNC
A
T
L
---
L
F
L
-GT--N--
D
E
D
T
M
K
Y
F
S
MRAGK
Q
T
I
I
QTSYSEQRGHRISGTTSR
Q
A
H
QRDLM
T
P
D
--
E
I
A
R
IGV
D
E
A
---
L
V
F
I
SK
Q
N
V
F
R
D
K
K
A
M
VSNH
P
M
K
D
R
L
A
N
---------
H
Y-QD
K
T
W
Y
H
Y
K
R
F
M
E
E
G
A
E
F
I
D
A
V
MTGQIPEDRIWAP
D
M
S
D
-
Y
Q
A
F
L
E
-------ENGFDNTRQSAPETSVHNQVPVT---NPEMPSESPSQ
T
S
E
T
S
K
K
L
V
DMDTG
E
I
FELPPEDREGFGEVS------FDDQR--VEI-------
8
HHSearch
86.36
18%
-69
- C3 -
1E9R
2
?
A:
[19-430]
-------------------------------------------------------------------------------------------------------------------------------------
R
G
T
R
I
V
S
G
-------------
G
K
L
K
R
M
T
R
E
-
K
A
K
Q
V
T
V
A
------------------------------
G
V
P
-
M
P
-
R
D
A
E
P
R
H
L
L
V
N
G
A
-
T
-
G
T
G
K
S
V
L
L
R
E
L
A
-----
Y
T
-----------
G
L
---
L
R
G
D
R
M
---
V
I
V
D
P
N
G
D
M
L
S
K
F
G
-
R
-------
D
K
---
D
I
I
L
N
P
Y
D
Q
-
R
T
K
-------------
G
W
S
F
-
F
N
-----------
E
I
R
N
D
Y
D
W
Q
R
Y
A
L
S
V
V
P
R
G
K
---
T
D
E
A
E
E
--------
W
A
S
Y
G
---------------------------------------
R
L
L
L
R
E
T
-
A
K
K
L
A
L
I
G
-----
T
-----------
P
S
M
R
-
E
L
--
F
H
W
T
T
I
A
T
F
-------------
D
D
L
R
G
F
L
E
-
G
----------------
T
--
L
A
-
E
S
L
F
A
-----
G
-
S
N
E
A
S
K
A
L
T
S
---
A
R
F
V
----
L
S
D
K
L
P
----------------
E
H
V
T
M
P
D
G
D
F
S
-
I
---
R
S
W
L
E
D
PN
G
G
N
-
L
F
I
-----------
T
W
-
R
---
E
D
M
G
P
A
L
R
P
L
I
S
A
W
V
D
V
V
C
T
S
I
L
S
L
P
E
-----
E
P
K
-------
R
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
--
S
RT
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
-------------
R
A
L
E
R
V
R
E
R
V
V
M
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
84.16
16%
-62
- C3 -
1E9R
2
?
A:
[4-436]
------------------------------------------------------------------------------------------------------------------------------------
V
G
Q
G
E
F
G
G
A
-------------
P
F
K
R
F
L
R
G
T
R
I
V
S
G
G
K
L
K
R
-
M
T
R
E
K
A
K
Q
V
T
-----------------
V
A
G
V
-
P
M
P
R
D
A
E
P
R
H
L
L
V
N
G
A
-
T
-
G
T
G
K
S
V
L
L
--
R
E
L
A
---
Y
T
-----------
G
L
---
L
R
G
D
R
M
---
V
I
V
D
P
N
G
D
M
L
S
K
F
G
----
R
D
-
K
D
I
I
---
L
N
P
Y
D
----
Q
R
T
K
-------------
G
W
S
F
-
F
N
-----------
E
I
R
N
D
Y
D
W
Q
R
Y
A
L
S
V
V
---
P
R
G
K
T
D
E
A
E
E
--------
W
A
S
Y
G
---------------------------------------
R
L
L
L
R
E
T
-
A
K
K
L
A
L
I
G
T
----------------
P
S
M
R
-
E
L
--
F
H
W
T
T
I
-----------------
A
T
F
D
D
L
R
-
G
F
----------
L
E
G
--
T
--
L
A
-
E
S
L
F
A
--
G
S
N
E
A
S
K
A
L
T
S
A
R
F
V
---
L
S
D
K
L
P
E
H
V
T
----------------------
M
--
P
D
G
D
F
S
-
I
---
R
S
W
L
E
D
--
P
N
G
-
G
N
L
-----------
F
I
-
T
WRE
D
M
-
G
P
A
L
R
P
L
I
S
A
W
V
D
V
V
C
T
S
I
L
S
L
P
E
------------
E
P
K
R
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
SR
T
--
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
R
-------------
A
L
E
R
V
R
E
R
V
V
M
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
70.69
18%
-29
- C1 -
2HG4
2
ERYA3_SACER
A:
[9-901]
EE
K
L
R
R
Y
L
K
R
T
V
T
E
L
D
S
V
T
A
R
L
R
E
V
E
H
R
A
G
EPIA
I
V
G
M
A
C
R
F
P
G
D
V
D
S
P
E
S
F
W
E
F
V
S
G
G
G
D
A
I
A
E
A
P
A
D
RGWEPDP
D
A
R
L
G
GMLAAAGDFDAG
F
F
G
I
S
P
R
E
A
L
A
M
D
P
Q
Q
R
I
M
L
E
I
S
W
E
A
L
E
R
A
G
H
D
P
V
S
L
R
G
S
A
T
G
V
F
T
G
V
G
T
VDYGPRPDEAP
D
E
V
L
G
Y
V
G
T
G
T
A
S
S
V
A
S
G
R
V
A
Y
C
L
G
----
L
E
G
P
A
M
T
V
D
TACS
S
G
L
T
A
L
H
L
A
M
E
S
L
R
R
D
E
C
G
L
A
L
A
G
G
V
T
V
M
S
S
P
G
A
F
T
E
--
F
R
-----
S
Q
GGLAADGRCKP
F
S
---
K
A
A
D
G
F
---
G
L
A
E
G
A
G
V
L
V
L
Q
R
L
-
S
A
A
R
R
-
E
G
R
P
---
V
L
A
V
L
R
G
S
A
V
N
Q
D
GASNGLTAPS
G
P
A
Q
Q
R
V
-
I
R
-----------
R
A
L
E
N
A
G
V
R
A
G
D
V
D
Y
V
E
A
H
G
T
G
T
R
L
G
D
P
I
--------
E
V
H
A
L
L
S
T
YGAERDPD
D
P
L
W
I
G
S
VKSNIGHTQAA
A
G
V
A
G
V
M
K
A
V
L
A
L
R
H
G
E
M
P
R
T
L
H
F
D
E
P
S
P
Q
I
E
-----------
W
A
V
S
-
V
V
S
Q
A
R
S
W
P
A
G
E
R
P
R
R
A
G
V
S
S
F
G
ISG
T
N
A
H
V
I
V
E
-
E
A
PEADG
P
V
P
L
V
L
S
G
--
R
D
E
Q
A
M
R
A
Q
A
G
R
L
A
D
H
L
A
R
E
P
R
N
S
L
R
D
T
G
F
T
L
A
T
R
R
S
A
W
E
H
R
A
V
V
V
G
D
R
D
E
A
L
A
G
L
R
A
V
A
D
G
R
I
--
A
D
R
T
A
T
-
G
---
Q
A
R
T
R
R
--
G
V
A
M
V
F
P
G
Q
GAQWQGMA
R
D
L
-
L
---
R
E
-
S
Q
V
F
A
D
S
I
R
D
C
E
R
A
L
A
P
H
V
D
W
S
L
T
D
L
L
S
G
A
R
P
L
D
R
V
D
V
V
Q
P
-
A
L
F
A
V
M
V
S
L
A
A
L
W
R
-------
S
------
H
G
V
E
P
A
A
V
V
G
H
S
Q
G
E
I
A
A
A
H
V
A
G
A
L
T
L
E
D
A
A
K
L
V
A
V
R
S
R
V
L
R
R
L
G
G
Q
G
G
M
A
S
F
-
G
L
--
G
--
T
E
Q
A
A
E
R
I
G
R
F
A
G
A
--
L
S
I
A
S
V
N
G
P
R
S
V
V
V
A
G
E
S
G
P
L
D
E
L
I
A
E
C
E
A
E
AH
K
A
R
R
I
P
V
D
Y
A
SHS
P
Q
V
E
S
L
R
E
E
L
L
T
E
L
A
G
I
S
P
V
S
A
D
V
A
L
Y
S
TTTGQPIDT
A
T
M
D
T
A
Y
W
Y
A
N
L
R
---
E
Q
V
R
F
Q
D
A
--
T
R
Q
L
A
E
--------
A
G
-
F
D
A
F
V
E
VSPHPVL
T
V
G
I
E
A
T
L
D
S
A
L
P
A
D
A
G
A
C
V
V
G
T
L
RR
D
R
G
G
L
A
D
F
H
T
A
L
G
E
A
Y
A
Q
G
V
E
V
D
W
S
P
A
F
--
A
D
A
R
P
V
E
L
P
V
Y
P
------
F
Q
R
Q
R
Y
W
L
P
I
-------
35
Fugue
68.56
13%
-19
- C4 -
4GUA
19
POLN_SINDV
A:
[7-668]
-------
N
P
F
S
C
K
T
N
V
C
W
A
K
A
L
E
P
I
L
A
T
A
-----
G
I
V
-
L
T
G
C
Q
-
W
S
E
L
F
P
Q
F
A
D
----------
D
K
P
H
-----------------------------
S
A
I
Y
A
L
D
-
V
I
C
I
K
F
-
F
G
M
-----
D
L
T
S
G
L
F
S
K
Q
S
I
P
L
T
Y
H
P
A
D
S
-------------
A
R
P
V
A
H
W
D
N
S
P
G
T
R
K
Y
G
Y
D
-
H
A
I
A
A
----
E
-----------------
L
S
R
R
-
F
P
V
F
Q
L
A
G
K
G
T
Q
L
D
L
Q
-
T
-
G
R
T
R
V
I
S
---
A
Q
-----
H
N
-----------
L
V
---
P
V
N
R
N
L
P
H
A
L
V
P
E
Y
K
E
K
Q
P
G
P
V
K
-
K
F
L
N
Q
F
K
H
H
S
---
V
L
V
V
S
E
E
K
I
E
A
P
R
-------------
K
R
I
E
-
W
I
-----------
A
P
I
G
I
A
G
A
D
K
N
Y
N
-
L
A
F
G
F
P
P
Q
A
R
Y
D
L
V
F
I
N
I
G
T
K
Y
R
N
H
H
F
Q
---------------------------------------
Q
C
E
D
H
A
A
-
T
L
K
T
L
S
R
S
A
L
N
C
L
N
-----------
P
G
G
T
-
L
V
--
V
K
S
Y
G
Y
A
D
R
N
S
E
D
V
V
T
A
L
----
A
R
K
F
V
R
V
S
-
A
A
----------
R
P
D
CV
S
--
S
N
-
T
E
M
Y
L
I
F
R
Q
L
D
N
S
R
T
R
Q
F
T
P
H
H
---
L
N
C
V
I
S
S
V
Y
E
G
T
R
D
----------------
G
V
G
--
A
A
P
S
Y
R
-
T
K
RE
N
I
A
D
C
Q
--
E
E
A
-
V
V
N
-----------
A
A
-
N
---
P
L
-
G
R
P
G
E
G
V
C
R
A
I
Y
K
R
W
P
T
S
F
T
D
S
A
T
E
T
G
T
A
R
M
T
V
C
L
G
K
K
V
I
H
A
V
G
P
D
F
-
R
K
H
P
E
A
E
A
-------
L
------
K
L
L
Q
-
N
A
Y
H
A
V
A
D
L
V
N
E
H
N
I
K
S
V
A
I
P
L
L
S
T
G
I
Y
A
A
G
K
D
R
L
E
V
S
L
N
C
L
---
T
T
A
L
D
R
--
T
--
D
A
D
V
T
I
Y
C
-------------
L
D
K
K
W
K
E
R
I
D
A
A
L
Q
L
K
E
S
V
T
E
L
K
D
E
D
------
M
E
I
D
D
E
---
L
V
W
I
H
P
D
S
C
L
K
G
R
K
----
G
F
S
T
T
K
G
K
L
Y
---------
S
Y
-
F
E
G
T
--
K
F
H
Q
A
A
K
D
M
A
E
I
K
V
L
F
P
N
D
Q
E
S
N
E
Q
L
C
A
Y
I
L
G
E
T
M
E
A
I
R
E
-------
K
C
P
V
D
H
N
P
S
S
S
P
P
K
T
L
P
C
L
C
M
Y
A
------
M
T
P
E
R
V
H
R
L
R
S
N
N
V
K
E
V
T
V
C
S
S
--
T
P
L
P
K
H
K
I
K
N
V
Q
K
V
Q
C
T
K
V
V
L
F
N
P
H
T
--
P
A
F
VPARKYI
4
PsiBlast_PDB
59.08
26%
-53
- C3 -
1GL6
2
?
A:
[279-399]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
--
S
RT
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
-------------
A
L
E
R
V
R
E
R
V
V
M
-
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
56.36
26%
-55
- C3 -
1GKI
1
?
A:
[280-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
--
S
RT
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
-------------
A
L
E
R
V
R
E
R
V
V
M
-
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
56.01
26%
-56
- C3 -
1E9S
-
?
A:
[350-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
--
S
RT
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
R
Y
S
K
--------
R
A
L
E
R
V
R
E
R
V
V
M
-
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
I
----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
55.04
26%
-53
- C3 -
1E9R
-
?
A:
[280-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
L
W
L
F
I
-
D
E
L
A
S
L
E
K
-------
L
------
A
S
L
A
-
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
---
V
V
L
-
G
G
--
S
RT
D
P
K
T
N
E
D
M
S
L
S
L
G
E
H
E
V
E
R
D
------------
R
A
L
E
R
V
R
E
R
V
V
M
-
P
A
--
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
N
R
Q
P
A
F
V
---------
E
G
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
40.83
13%
-38
- C3 -
2IUS
-
FTSK_ECOLI
A:
[1114-1188]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
-
I
V
V
L
V
-
D
E
F
A
D
L
M
M
T
V
G
K
K
V
-
E
------
E
L
I
A
-
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
--
V
I
T
----
G
L
I
K
A
N
I
P
T
R
---
I
A
F
-
T
V
--
S
--
S
K
I
D
S
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.95
31%
32
- C3 -
2Z0M
-
?
A:
[22-80]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
T
-
I
P
L
M
L
Q
-
G
K
N
V
V
V
R
A
K
-
T
-
G
S
G
K
T
A
A
Y
--
A
I
-----
P
------------
I
L
---
E
L
G
M
K
S
---
L
V
V
T
P
T
R
E
L
T
R
Q
V
A
-
S
H
I
R
D
-
I
G
R
Y
---
M
D
T
K
V
A
E
V
Y
G
G
M
P
-------------
Y
K
A
Q
-
I
N
-----------
R
V
R
N
A
D
I
V
V
A
T
P
G
R
L
L
D
L
W
S
K
G
V
I
D
L
S
S
F
--------
E
I
V
I
I
---------------------------------------
D
E
A
D
L
M
F
-
E
M
G
F
I
D
D
I
K
I
I
L
A
Q
-----------
T
S
N
R
-
K
I
--
T
G
L
F
S
A
T
I
P
E
E
I
R
K
V
V
K
D
----
F
I
T
N
Y
E
E
I
-
E
A
----------
C
I
G
--
L
--
A
N
-
V
E
H
K
F
V
H
V
K
D
D
W
R
S
K
V
Q
A
L
R
E
N
---
K
D
K
G
V
I
V
F
V
R
T
R
N
R
----------------
V
A
K
--
L
V
R
L
F
D
-
N
---
A
I
E
L
R
G
--
D
L
P
-
Q
S
V
-----------
R
N
-
R
---
N
I
-
D
A
F
R
E
G
E
Y
D
M
L
I
T
T
D
V
A
S
R
G
L
D
I
P
L
V
E
K
V
I
N
F
D
A
P
Q
D
L
R
T
Y
-
I
H
R
I
G
-
R
T
G
R
M
G
R
K
-------
G
------
E
A
I
T
-
F
I
L
N
E
Y
W
L
E
K
E
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.89
24%
-1
- C3 -
3NVA
-
PYRG_SULSO
A:
[18-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
T
L
V
A
S
I
G
-
M
L
L
K
R
-
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
-------------
M
-
N
P
--------------
Y
M
H
G
E
V
---
F
V
T
E
D
G
A
E
-
T
D
L
D
L
G
H
Y
E
R
F
--------
M
D
V
N
M
---------------------------------------
T
K
Y
N
N
I
T
-
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
GKYLGQTVQII
P
H
V
T
D
Q
I
--
K
D
M
I
R
Y
A
S
K
I
N
N
A
E
I
T
L
V
----
E
I
G
G
T
V
G
D
I
E
S
----------
L
P
F
--
L
--
E
A
-
V
R
Q
L
K
L
---------
E
E
G
E
D
N
V
---
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
----------------
G
E
L
--
K
T
K
P
L
Q
-
H
---
S
V
Q
E
L
R
--
R
I
G
-
I
Q
P
-----------
D
F
-
I
---
V
G
-
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
-
E
S
Q
K
L
-
V
S
K
I
L
S
R
L
-------
K
------
L
E
D
R
-
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
G
I
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
---
E
A
I
-
Y
H
--
A
--
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
L
E
S
D
T
K
N
L
N
E
I
L
G
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
--
G
K
I
K
A
I
K
Y
A
R
---
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
---------
E
A
-
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
N
V
T
Q
L
G
G
T
M
R
L
G
A
Q
K
I
I
L
-
K
E
G
T
I
A
-------
Y
Q
L
Y
G
K
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
---
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
E
N
G
L
V
E
I
I
E
L
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
------
R
P
T
N
P
--
S
P
I
-------
36
Fugue
39.76
12%
-0
* C4 *
3EA0
3
?
A:
[3-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
R
V
F
G
F
V
S
A
K
-
G
-
G
D
G
G
S
C
I
A
--
A
N
-----
F
A
-----------
F
A
L
S
Q
E
P
D
I
H
V
---
L
A
V
D
I
S
-
L
P
F
G
D
L
D
M
Y
L
S
G
N
-
T
H
S
Q
D
L
-
A
D
I
S
N
A
S
D
R
L
D
K
S
-------------
L
L
D
T
M
V
Q
-----------
H
I
S
P
S
L
D
L
I
P
S
P
A
T
F
E
K
I
V
N
I
E
P
E
R
V
S
D
L
--------
I
H
I
A
A
---------------------------------------
S
F
Y
D
Y
I
I
-
V
D
F
---
G
A
S
I
D
H
V
G
-----------
V
W
V
L
-
E
H
--
L
D
E
L
C
I
V
T
T
P
S
L
Q
S
L
R
R
A
----
G
Q
L
L
K
L
C
K
-
E
F
---------------
E
--
K
P
-
I
S
R
I
E
I
I
L
N
R
A
D
T
N
S
R
I
T
S
D
E
I
---
E
K
V
I
-----
G
R
P
I
S
----------------
K
R
I
--
P
Q
D
E
D
A
M
Q
---
E
S
L
L
S
G
--
Q
S
V
-
L
K
V
-----------
A
P
K
S
---
Q
L
-
S
K
T
I
V
D
W
A
L
H
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
39.22
14%
-36
- C3 -
2IUT
-
FTSK_PSEAE
A:
[343-417]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
-
I
V
V
V
V
-
D
E
F
A
D
M
M
M
-------
I
V
G
K
K
V
E
E
L
I
A
-
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
--
V
----
I
T
G
L
I
K
A
N
I
P
T
R
---
I
A
F
-
Q
V
--
S
--
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
--
R
V
V
E
A
W
K
L
R
G
---
A
P
D
Y
I
E
D
I
L
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
37.02
32%
56
- C3 -
2Z0M
-
?
A:
[30-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
K
N
V
V
V
R
A
K
-
T
-
G
S
G
K
T
A
A
Y
--
A
I
-----
P
I
-----------
L
----
E
L
G
M
K
S
---
L
V
V
T
P
T
R
E
L
T
R
Q
V
A
-
S
H
I
R
D
-
I
G
R
Y
---
M
D
T
K
V
A
E
V
Y
G
G
M
P
-------------
Y
K
A
Q
-
I
N
-----------
R
V
R
N
A
D
I
V
V
A
T
P
G
R
L
L
D
L
W
S
K
G
V
I
D
L
S
S
F
--------
E
I
V
I
I
---------------------------------------
D
E
A
D
L
M
F
-
E
M
G
F
I
D
D
I
K
I
I
L
A
Q
-----------
T
S
N
R
-
K
I
--
T
G
L
F
S
A
T
I
P
E
E
I
R
K
V
V
K
D
----
F
I
T
N
Y
E
E
I
-
E
A
----------
C
I
G
--
L
--
A
N
-
V
E
H
K
F
V
H
V
K
D
D
W
R
S
K
V
Q
A
L
R
E
N
---
K
D
K
G
V
I
V
F
V
R
T
R
N
R
----------------
V
A
K
--
L
V
R
L
F
D
-
N
---
A
I
E
L
R
G
--
D
L
P
-
Q
S
V
-----------
R
N
-
R
---
N
I
-
D
A
F
R
E
G
E
Y
D
M
L
I
T
T
D
V
A
S
R
G
L
D
I
P
L
V
E
K
V
I
N
F
D
A
P
Q
D
L
R
T
Y
-
I
H
R
I
G
-
R
T
G
R
M
G
R
K
-------
G
------
E
A
I
T
-
F
I
L
N
E
Y
W
L
E
K
E
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
36.45
24%
-24
- C3 -
2V1X
3
RECQ1_HUMAN
A:
[58-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
E
V
F
L
V
M
P
-
T
-
G
G
G
K
S
L
C
Y
--
Q
L
-----
P
A
-----------
L
C
---
S
-
D
G
F
T
---
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
-
M
V
L
K
Q
-
L
G
I
S
---
A
T
M
L
N
A
S
S
S
K
E
H
V
-------------
K
W
V
H
-
A
E
-----------
M
V
N
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
K
M
F
M
S
R
L
E
--------
K
A
Y
E
A
---------------------------------------
R
R
F
T
R
I
A
-
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
-----------
R
P
D
Y
-
K
A
--
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
G
L
T
A
----
T
A
T
N
H
V
L
T
-
D
A
----------
Q
K
I
--
L
--
C
I
-
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
---
P
S
N
T
E
D
F
I
E
D
I
V
K
L
----------------
I
N
G
--
R
Y
K
G
Q
S
-
G
---
I
I
Y
C
F
S
--
Q
K
D
-
S
E
Q
-----------
V
T
-
V
---
S
L
-
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
-
M
G
I
D
K
-
P
D
V
R
F
V
I
H
-------
H
------
S
M
S
K
-
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
---
G
Q
Q
-
K
L
--
Y
--
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
A
C
N
K
M
C
D
N
C
C
K
D
S
A
F
E
R
K
N
I
T
E
--
Y
C
R
D
L
I
K
I
L
K
---
Q
A
E
E
L
N
E
K
L
T
P
L
K
L
I
D
S
W
M
G
K
G
A
A
K
L
R
V
---------
A
G
-
V
V
A
P
T
L
P
R
E
D
L
E
K
I
I
A
H
F
L
I
Q
Q
Y
L
K
E
D
Y
S
F
T
A
Y
A
T
I
S
Y
L
-
K
I
G
P
K
A
-------
N
L
L
N
N
E
A
H
A
I
T
M
Q
V
T
K
---------------------------------------------------------------------------
38
Fugue
35.65
11%
25
- C4 -
1Y63
15
?
A:
[6-179]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
P
K
G
I
N
I
L
I
T
G
T
-
P
-
G
T
G
K
T
S
M
A
--
E
M
I
A
A
E
L
D
G
-----------
F
Q
---
H
L
E
V
G
K
---
L
V
K
E
N
H
F
Y
T
E
T
H
I
I
-
E
E
K
D
E
-
D
R
L
L
---
D
F
M
E
P
I
M
V
S
R
G
N
H
-------------
V
V
D
Y
-
H
S
SELFPERWFH
M
V
V
V
L
H
T
S
T
E
V
L
F
E
R
L
T
K
R
Q
Y
S
E
A
K
R
A
E
N
M
--------
E
A
E
I
Q
---------------------------------------
C
I
C
E
E
E
A
-
R
D
A
Y
E
D
D
I
V
L
V
R
E
N
-----------
D
T
L
E
-
Q
M
--
A
A
T
V
E
E
I
R
E
R
V
E
V
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
33.75
17%
257
- C3 -
1HF9
-
B:
[1-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
K
H
H
E
-----------
N
E
I
S
-
H
H
--
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
----
K
K
L
K
Q
S
E
D
-
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
33.74
17%
257
- C3 -
1HF9
-
ATIF1_BOVIN
A:
[1-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
K
H
H
E
-----------
N
E
I
S
-
H
H
--
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
----
K
K
L
K
Q
S
E
D
-
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
32.27
17%
-11
- C3 -
2R2A
-
?
A:
[87-151]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
-
S
I
V
I
V
-
D
E
A
Q
D
V
W
P
ARSAGSK
I
------
P
E
N
V
-
Q
W
L
N
T
H
R
H
Q
G
I
D
I
F
V
L
T
Q
G
P
K
L
L
D
--------
Q
N
L
R
T
L
V
R
K
H
---
Y
H
I
-
A
S
--
N
--
K
M
G
M
R
T
L
L
E
W
K
I
C
A
D
D
P
V
K
M
A
S
S
A
F
S
S
I
Y
T
L
D
K
K
V
Y
D
L
Y
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
31.07
24%
368
- C3 -
1P9I
-
?
A:
[3-31]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
--
N
A
L
L
A
S
L
E
A
E
N
K
Q
L
K
A
K
V
----
E
E
L
L
A
K
V
G
-
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------