@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1172: (2015-12-06 )
MIKVIATDMDGTFLRSDKTYDKARFSSLLTLMEKYDIKFVAASGNLYDQLLLNFLEYPNRIAYVAENGGRVIDQDGTLLKETYLSNDTVAAVLSYLYQNYPETLISLSGEKRSYLERRTPINRRTELEYYMPNFIYKDHLLPLDDDRYFQMTLWVNENLVSEMLLDISEHFKNHHIRLTSSGFGCIDVLPADVNKADGIAILLEKWGLKQDQVMVFGDGGNDVEMLRAANISYAMSNAPEEIKAIAKYQTVSNDQDGVLETIENFLHKMSDNE
Atome Classification :
(20 SA)
.........10.....-.-.-.20.........30........40....-------....50.....--...60........70..-..-----------------....80........90........100.......110....-...120-......-.---------.130--..---------------------....--.--.140----..-.-.--....150....-.-.-..160-.......-..170---.......180.......190.......200.......210.......220.......230.......240......--.250.......260.......270.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
V
I
A
TDMD
G
T
F
LRS-D-K-T
Y
-
D
K
A
R
F
S
S
L
L
T
L
M
E
KY
D
I
K
F
V
AASG
N
-------
L
Y
D
Q
L
L
L
N
F
LE--YP
N
R
I
A
Y
V
AENG
G
R
V
ID-QD-----------------GT
L
L
K
E
TYLSN
D
T
V
A
A
V
L
S
Y
L
Y
Q
NY
P
E
T
L
I
SLSG
E
K
R
S
Y
L
E
-RRTPI--NRRT
E
L
-
E
---------YY-M--P
N
---------------------
F
I
YK--D--HLL-----PL-D-D--D
R
Y
F
Q
-
M
T
L
W
V-N-
E
-
N
L
V
---
S
E
M
L
L
D
I
-
S
E
H
FK---NH
H
I
R
L
TSSGF
G
C
I
DVLPADVNKAD
G
I
A
I
L
L
E
KWGLKQD
Q
V
M
V
F
GDGGN
D
V
E
M
L
R
AAN
I
S
YAMSNA
P
E
E
I
K
A
I
A
K
Y--QTVSNDQ
D
G
V
L
E
T
I
E
N
F
L
H
K
MSDNE
1
PsiBlast_PDB
98.78
39%
-105
- C1 -
3L7Y
1
?
A:
[37-300]
-
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
-
K
-
G
-
S
Y
-
D
H
N
R
F
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
-------
P
Y
R
Q
L
R
E
H
F
P
D
--
C
H
E
Q
L
T
F
V
G
E
N
G
A
N
I
I
S
-
K
N
-----------------
Q
S
L
I
-
E
V
F
Q
Q
R
E
D
I
A
S
I
I
Y
F
I
E
E
K
Y
P
Q
A
V
I
A
L
S
G
E
K
K
G
Y
L
K
-
K
G
V
S
E
--
N
I
V
K
M
L
-
S
---------
P
F
-
F
--
P
V
---------------------
L
E
L
V
--
N
--
S
F
S
-----
P
L
-
P
----
E
R
F
F
K
-
L
T
L
Q
V
-
K
-
E
-
E
E
S
---
A
Q
I
M
K
A
I
-
A
D
Y
K
T
---
S
Q
R
L
V
G
T
A
S
G
F
G
Y
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
--
Q
A
K
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
S
-----
45
HHSearch
97.90
38%
-99
- C1 -
3L7Y
1
?
A:
[36-302]
S
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
-
K
-
G
-
S
Y
D
H
N
R
F
-
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
-------
P
Y
R
Q
L
R
E
H
F
P
D
--
C
H
E
Q
L
T
F
V
G
E
N
G
A
N
I
I
S
-
K
N
-----------------
Q
S
-
L
I
E
V
F
Q
Q
R
E
D
I
A
S
I
I
Y
F
I
E
E
K
Y
P
Q
A
V
I
A
L
S
G
E
K
K
G
Y
L
K
-
K
G
V
S
E
--
N
I
V
K
M
L
-
S
---------
P
F
-
F
--
P
V
---------------------
L
E
L
V
--
N
--
S
F
S
-----
P
L
-
P
----
E
R
F
F
K
-
L
T
L
Q
V
-
K
-
E
-
E
E
S
---
A
Q
I
M
K
A
I
-
A
D
Y
K
T
---
S
Q
R
L
V
G
T
A
S
G
F
G
Y
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
--
Q
A
K
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
S
-----
40
HHSearch
85.90
33%
-95
- C1 -
1RLM
3
SUPH_ECOLI
A:
[2-268]
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
N
Q
P
R
F
-
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
------------------
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
-
E
N
A
P
E
--
A
F
V
A
L
M
-
A
---------
K
H
-
Y
--
H
R
---------------------
L
K
P
V
--
K
--
D
Y
Q
-----
E
I
---
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
L
V
I
D
K
L
-
H
V
A
L
----
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
26
PsiBlast_CBE
85.75
34%
-92
- C1 -
1RLM
2
SUPH_ECOLI
B:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
23
PsiBlast_CBE
85.40
34%
-88
- C1 -
1RLT
2
SUPH_ECOLI
B:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
24
PsiBlast_CBE
85.36
34%
-91
- C1 -
1RLM
2
SUPH_ECOLI
D:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
21
PsiBlast_CBE
84.97
34%
-92
- C1 -
1RLT
3
SUPH_ECOLI
D:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
25
PsiBlast_CBE
84.09
34%
-86
- C1 -
1RLM
3
SUPH_ECOLI
C:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
46
HHSearch
83.69
26%
-105
- C1 -
3DAO
1
?
A:
[20-283]
M
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
-
G
-
S
L
L
I
-
D
P
E
Y
-
M
S
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
-------
Q
F
S
S
E
F
K
L
F
A
P
--
I
K
H
K
L
L
Y
I
T
D
G
G
T
V
V
R
T
-
P
------------------
K
E
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
M
C
R
M
V
R
D
E
L
P
A
C
D
Y
F
A
A
T
P
D
F
C
F
A
E
-
D
G
G
S
P
---
I
F
H
L
L
R
D
---------
S
Y
-
G
--
F
E
---------------------
M
R
E
V
--
D
--
D
I
T
-----
R
L
-
D
-
R
--
N
D
I
I
K
-
F
T
V
F
H
-
P
-
D
-
K
-
C
---
E
E
L
C
T
P
V
F
I
P
A
W
----
N
K
K
A
H
L
A
A
A
G
K
E
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
--
T
C
A
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-------
2
PsiBlast_PDB
83.57
34%
-88
- C1 -
1RLM
3
SUPH_ECOLI
A:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQL
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
3
PsiBlast_PDB
82.97
34%
-84
- C1 -
1RLT
3
SUPH_ECOLI
A:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQL
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
22
PsiBlast_CBE
82.50
34%
-85
- C1 -
1RLT
3
SUPH_ECOLI
C:
[3-263]
-
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
-------
Q
Y
Y
Q
L
I
S
F
F
P
E
--
L
K
D
E
I
S
F
V
A
E
N
G
A
L
V
Y
E
-
H
G
KQLFHGELTRHESRIVI
G
E
L
L
K
D
K
Q
L
N
F
V
A
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
V
A
L
M
A
K
---
H
Y
H
-
R
L
K
P
V
--
K
D
Y
Q
E
I
--------------------------------------------------------------
D
--
D
V
L
F
K
-
F
S
L
N
L
-
P
-
D
-
E
Q
I
---
P
-
L
V
I
D
K
-
L
H
V
A
L
---
D
G
I
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
N
6
PsiBlast_PDB
79.96
25%
-95
- C1 -
3DAO
1
?
A:
[21-283]
-
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
-
G
-
S
-
L
L
-
I
D
P
E
Y
M
S
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
-------
Q
F
S
S
E
F
K
L
F
A
P
--
I
K
H
K
L
L
Y
I
T
-
D
G
G
T
V
V
R
-
T
P
-----------------
K
E
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
M
C
R
M
V
R
D
E
L
P
A
C
D
Y
F
A
A
T
P
D
F
C
F
A
E
D
G
G
S
P
I
--
F
H
L
L
R
D
-
S
---------
Y
------
G
---------------------
F
E
M
R
E
V
D
--
D
I
T
-----
R
L
-
D
-
R
--
N
D
I
I
K
-
F
T
V
F
--
H
-
P
-
D
K
C
---
E
E
L
C
T
P
V
-
F
I
P
A
W
---
N
K
K
A
H
L
A
A
A
G
K
E
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
--
T
C
A
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-------
42
HHSearch
74.39
23%
-79
- C1 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
-
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
-------
A
H
F
D
V
M
S
I
F
E
P
--
L
G
I
K
T
W
V
I
S
A
N
G
A
V
I
H
D
-
P
E
-----------------
G
R
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
E
--
N
Y
Y
Y
E
V
F
T
G
S
A
I
Y
T
P
-
Q
N
G
R
E
--
L
L
D
V
E
L
-
D
---------
R
F
-
R
--
S
A
NPEAD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
SG
F
A
Y
I
--
N
--
S
F
Q
-----
E
L
F
E
A
D
E
P
I
D
F
Y
N
-
I
L
G
F
S
F
F
-
K
-
E
K
L
---
E
A
G
W
K
R
Y
--
E
H
A
----
E
-
D
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-------
38
HHSearch
72.52
19%
-93
* C1 *
3FZQ
7
?
A:
[4-272]
L
Y
K
L
L
I
L
D
I
D
G
T
L
R
D
E
-
V
-
Y
-
G
I
-
P
E
S
A
-
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
-------
S
M
G
T
I
Q
D
D
V
L
S
--
L
G
-
V
D
G
Y
I
A
G
G
G
N
Y
I
Q
Y
--
H
-----------------
G
E
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
L
L
K
K
R
--
E
V
A
F
S
I
E
S
Q
E
K
V
F
M
N
-
Q
K
A
K
E
I
F
E
T
M
N
Q
L
-
K
GTNSCINKQ
H
I
-
Q
--
E
K
---------------------
I
T
Y
E
--
N
--
N
I
E
-----
E
Y
-
K
-
S
--
Q
D
I
H
K
-
I
C
L
W
S
-
N
-
E
-
K
V
F
---
D
E
V
K
D
I
L
-
Q
D
K
M
------
E
L
A
Q
R
D
I
S
S
Q
Y
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
--
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
N
I
I
-----
50
HHSearch
71.93
22%
-82
- C1 -
3R4C
4
?
A:
[11-267]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
E
T
-
H
-
K
V
-
S
Q
S
S
-
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
-------
A
A
S
D
L
H
E
I
D
-
A
--
V
-
P
Y
D
G
V
I
A
L
N
G
A
E
C
V
L
-
R
D
-----------------
G
S
V
I
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
L
A
R
E
F
--
D
F
A
V
A
L
E
L
N
E
G
V
F
V
N
-
R
L
T
P
T
----
V
E
Q
I
-
A
---------
G
I
V
E
--
H
P
---------------------
V
P
P
V
--
V
--
D
I
E
-----
E
M
-
F
E
R
--
K
E
C
C
Q
-
L
C
F
Y
F
-
D
-
E
-
E
A
E
---
Q
K
V
M
P
L
L
---------
S
-
G
L
S
A
T
R
W
H
P
L
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
--
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
V
I
-----
5
PsiBlast_PDB
71.88
25%
-66
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[5-270]
-
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
A
R
A
R
-
G
V
N
V
V
L
T
T
G
R
-------
P
Y
A
G
V
H
-
N
Y
L
------
K
E
L
H
M
E
Q
P
G
D
Y
C
I
T
-
Y
N
-----------------
G
A
L
V
Q
K
A
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
S
H
F
H
A
L
D
-
R
T
T
L
Y
--
T
A
N
R
D
I
-
S
---------
Y
Y
-
T
V
H
E
S
---------------------
F
V
A
T
--
I
--
P
L
V
F
C
E
AE
K
M
-
D
-
P
--
N
T
Q
F
L
-
K
V
M
M
I
-
D
-
E
P
A
I
L
---
D
Q
A
I
A
R
I
-
P
Q
E
V
K
---
E
K
Y
T
V
L
K
S
A
P
Y
-
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
-----
47
HHSearch
71.85
23%
-85
- C1 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
P
-
D
-
H
-
F
L
-
T
P
Y
A
-
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
-------
H
Y
I
D
V
G
Q
I
R
D
N
--
L
G
I
R
S
Y
M
I
T
S
N
G
A
R
V
H
D
-
S
D
-----------------
G
Q
Q
I
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
I
V
R
N
D
-
P
K
I
V
T
N
V
Y
R
E
D
E
W
Y
M
N
-
R
H
R
---------------------
F
F
-
K
--
E
A
---------------------
V
F
N
Y
--
K
L
Y
E
P
G
-----
E
L
-
D
-
P
--
Q
G
I
S
K
-
V
F
F
T
C
-
E
D
H
-
E
H
L
---
L
P
L
E
Q
A
M
-
N
A
R
W
----
G
D
R
V
N
V
S
F
S
T
L
T
C
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
------
49
HHSearch
71.29
21%
-74
- C1 -
2RBK
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
-
E
T
H
-
R
I
-
P
S
S
T
-
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
-------
P
K
A
I
I
N
N
L
S
E
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
F
V
-
G
------------------
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
--
G
V
P
C
I
F
V
E
E
H
N
I
S
V
C
-
Q
P
N
E
M
---
V
K
K
I
F
-
Y
---------
D
F
-
L
--
H
V
N--------------------
V
I
P
T
--
V
--
S
F
E
-----
E
A
-
S
-
N
--
K
E
V
I
Q
-
M
T
P
F
I
-
T
-
E
-
E
E
E
---
K
E
V
---
L
--
P
S
I
----
P
-
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
-----
7
PsiBlast_PDB
70.93
26%
-90
- C1 -
4DW8
4
?
A:
[6-269]
--
K
L
I
V
L
D
L
D
G
T
L
T
N
S
-
K
-
K
-
E
I
-
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
-
G
I
R
L
V
L
A
S
G
R
PTYGI
V
P
L
A
N
E
L
R
M
N
--
E
--
F
G
G
F
I
--
L
S
Y
N
G
G
E
I
I
N
W
E
S
-----------------
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
S
I
L
T
Y
D
G
A
E
-----------
I
--
V
T
E
N
S
L
-
D
---------
P
Y
-
V
--
Q
K
---------------------
E
A
F
L
--
N
--
K
M
A
-----
I
R
-
E
-
T
--
N
D
F
L
T
D
I
T
L
P
V
-
A
-
K
-
C
L
I
V
G
D
A
G
K
L
I
P
V
-
E
S
E
L
C
I
R
L
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-------