@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1186: (2015-12-06 )
MRIIVPATSANIGPGFDSIGVALSKYLSIEVLEESTEWLVEHNLVNIPKDHTNLLIQTALHVKSDLAPHRLKMFSDIPLARGLGSSSSVIVAGIELANQLGNLALSQKEKLEIATRLEGHPDNVAPAIFGDLVISSIVKNDIKSLEVMFPDSSFIAFIPNYELKTSDSRNVLPQKLSYEDAVASSSVANVMVASLLKGDLVTAGWAIERDLFHERYRQPLVKEFGVIKQISTQNGAYATYLSGAGPTVMVLCSKEKEQPIVTELSKLCLDGQIQVLNIERKGVRVEKR
Atome Classification :
(20 SA)
--.........10----.-----------..-----...---.-.20--....----.----....30..-...-.--..40.-.--------.----------.-----.-----.----.--.50.........60....-----..---..-----70........80........90......-----------------..100.......110.....------.------.--------120.......130-..---..----.....140.-.....-.---.-150.-----.----.....160..-.....-.-.170...---------------------..-------.--------------------------.--------180...-.-...190.......200.......210...------....---.---.---220..----------.....230..-.....240...--....250...-....260....-.----.-.---270.......280......--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
R
I
I
V
PATSAN----I-----------GP-----G
F
D
---
S
-
I
G
---
V
A
L
S
----
K
----
Y
L
S
I
E
V
LE-ES
T
-
E
--
W
L
V
E
H-N--------L----------V-----N-----I----P--K
D
-
H
T
N
L
L
I
Q
T
A
L
H
V
KSD-----LA---
P
H
-----
R
L
K
M
FSDIPLARGLGSSS
S
V
I
V
A
G
I
E
L
A
-----------------
N
Q
L
G
N
L
ALS
Q
K
E
K
L
E
I
A
T
RL------E------G--------HPDN
V
A
P
A
I
F
G
---
D
L
---
V
I
----
S
S
I
V
K
N
D
-
I
-
K
S
L
E
V
-M---F-PDS
S
-----
F
----
I
A
F
IPN--YE-LKTSD-S-RNVLPQK---------------------LS-------
Y
--------------------------
E
--------
D
AVAS
S
-
S
-
V
A
N
V
M
V
A
S
L
LKGDLVTAG
W
A
I
E
R
D
--
L
F
H
------
E
R
Y
R
---
Q
---
P
---
L
V
K
E
F
----------
G
V
I
K
QISTQN-G
A
Y
A
T
Y
LSGAG--
P
T
V
M
V
L
CSKE-KEQ
P
I
V
T
E
L
S
K
-L----C-L---DG
Q
I
Q
V
L
N
I
ERK
G
V
RVEKR--------------
23
HHSearch
97.35
48%
-107
- C2 -
3HUL
2
KHSE_LISMO
A:
[3-290]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
----
L
----
Y
L
T
L
D
I
G
A
E
A
D
--
S
--
W
Y
I
E
H
-
N
I-------
G
----------
G
-----
G
-----
I
----
P
--
H
D
-
E
T
N
V
I
I
E
T
A
L
N
L
A
P
N
-----
L
T
---
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
--------
H
P
D
N
V
A
P
A
V
L
G
---
N
W
---
V
V
----
G
A
K
L
D
G
E
-
D
--
F
Y
V
R
-
H
---
L
F
P
-
C
A
-----
L
----
I
A
F
I
P
K
--
A
E
-
L
L
----------
P
D
T
---------------------
L
P
-------
F
--------------------------
K
--------
E
A
V
Q
A
S
-
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
--
L
W
--------------
S
---
Q
---
L
V
P
H
L
----------
A
Q
I
R
D
V
A
K
N
Q
-
G
A
Y
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
P
R
N
-
L
A
N
K
L
Q
T
S
L
Q
T
-
L
----
E
-
I
---
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
E
--------------
1
PsiBlast_PDB
97.33
48%
-108
- C2 -
3HUL
2
KHSE_LISMO
A:
[3-288]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
----
L
----
Y
L
T
L
D
I
G
A
-
E
A
D
-
S
--
W
Y
I
E
H
-
N
--------
I
----------
G
-----
G
G----
I
----
P
--
H
D
-
E
T
N
V
I
I
E
T
A
L
N
L
A
P
N
-----
L
T
---
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
--------
H
P
D
N
V
A
P
A
V
L
G
---
N
W
---
V
V
----
G
A
K
L
D
G
E
-
D
-
F
Y
V
R
H
-
L
---
F
-
P
-
C
A
-----
L
----
I
A
F
I
P
K
--
A
E
-
L
L
----------
P
D
T
---------------------
L
P
-------
F
--------------------------
K
--------
E
A
V
Q
A
S
-
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
--
L
W
--------------
S
---
Q
---
L
V
P
H
L
----------
A
Q
I
R
D
V
A
K
N
Q
-
G
A
Y
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
P
R
N
-
L
A
N
K
L
Q
T
S
L
Q
T
-
L
----
E
-
I
---
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
E
--------------
15
PsiBlast_CBE
95.88
48%
-101
- C2 -
3HUL
2
KHSE_LISMO
B:
[3-288]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
----
L
----
Y
L
T
L
D
I
G
A
-
E
A
D
-
S
--
W
Y
I
E
H
-
N
--------
I
---------------------------
P
--
H
D
-
E
T
N
V
I
I
E
T
A
L
N
L
A
P
N
-----
L
T
---
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
--------
H
P
D
N
V
A
P
A
V
L
G
---
N
W
---
V
V
----
G
A
K
L
D
G
E
-
D
-
F
Y
V
R
H
-
L
---
F
-
P
D
C
A
-----
L
----
I
A
F
I
P
K
--
A
E
-
L
L
----------
P
D
T
---------------------
L
P
-------
F
--------------------------
K
--------
E
A
V
Q
A
S
-
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
--
L
W
------------------------
P
H
L
----------
A
Q
I
R
D
V
A
K
N
Q
-
G
A
Y
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
P
R
N
-
L
A
N
K
L
Q
T
S
L
Q
T
-
L
----
E
-
I
---
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
E
--------------
24
HHSearch
75.48
28%
-73
- C2 -
1H72
3
KHSE_METJA
C:
[3-295]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
E---
P
----
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
T-
D
P
-
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
FNI--
G
K
---
G
V
-----
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
N
Y
E
P
--
L
-
E
V
L
H
I
-
P
---
I
D
F
K
L
D
-----
I
----
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
E
V
K
D
--
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----------
Y
E
N
T
I
R
T
E
V
G
-
K
G
V
E
V
V
----------------
48
Fugue
73.02
26%
-61
- C2 -
1H74
2
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
----
P
Y
D
V
I
E
V
E
-
A
I
D
-
D
K
E
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
-----
F
N
---
I
G
K
G
V
--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
------
L
A
S
SGAK--
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
N
Y
E
P
L
-
E
-
V
L
H
I
P
-
I
---
D
-
F
K
L
D
-----
I
----
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
---
K
G
V
E
V
V
----------------
47
Fugue
72.74
26%
-62
- C2 -
1FWK
1
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
----
P
Y
D
V
I
E
V
E
-
A
I
D
-
D
K
E
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
-----
F
N
---
I
G
K
G
V
--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
N
Y
E
P
L
-
E
-
V
L
H
I
P
-
I
---
D
-
F
K
L
D
-----
I
----
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
E
-
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
---
K
G
V
E
V
V
----------------
46
Fugue
72.47
26%
-60
- C2 -
1H72
3
KHSE_METJA
C:
[1-296]
MK
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
----
P
Y
D
V
I
E
V
E
-
A
I
D
-
D
KE
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
-----
F
N
---
I
G
KGV--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
N
Y
E
P
L
-
E
-
V
L
H
I
P
-
I
---
D
-
F
K
L
D
-----
I
----
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
---
K
G
V
E
V
V
----------------
3
PsiBlast_PDB
72.08
24%
-72
- C2 -
4RPF
1
KHSE_YERPN
A:
[3-308]
--
V
K
I
Y
A
P
A
S
I
G
N
----
V
-----------
S
V
-----
G
F
D
---
V
-
L
G
---
A
A
V
S
P
IDG
T
----
L
L
G
D
C
V
S
V
-
T
A
A
-
E
--
R
F
S
L
H
-
N
E
G
RF----
V
----------
S
-----
K
-----
L
----
P
--
D
D
P
K
Q
N
I
V
Y
Q
C
W
E
R
F
C
Q
E
-----
M
G
K
E
I
P
V
-----
A
M
V
L
E
K
N
M
P
I
G
S
G
L
G
S
S
A
C
S
V
V
A
G
L
M
A
M
-----------------
N
E
F
C
G
Q
P
L
D
K
V
T
L
L
G
M
M
G
E
L
------
E
------
G
R
V
SGSI--
H
F
D
N
V
A
P
C
Y
L
G
---
G
M
---
Q
L
I
L
EQ
E
G
Y
I
S
Q
D
-
V
-
P
G
--------
F
-
S
D
W
L
-----
W
----
V
M
A
Y
P
G
--
I
K
-
V
S
T
A
E
-
A
-
R
A
I
L
P
A
Q
---------------------
Y
R
-------
R
--------------------------
Q
--------
D
C
I
T
H
G
R
N
-
L
A
G
F
I
H
A
C
H
T
Q
Q
P
D
L
A
A
--
K
M
M
K
D
--
V
I
A
------
E
P
Y
R
---
T
---
Q
---
L
L
P
G
F
----------
A
A
A
R
Q
A
A
Q
D
I
-
G
A
L
A
C
G
I
S
G
S
G
--
P
T
L
F
A
V
C
N
D
Q
A
T
A
Q
R
M
A
G
W
L
Q
N
-
H
----
Y
-
L
QND
E
G
F
V
H
I
C
R
L
D
T
A
G
A
R
L
L
G
---------------
36
HHSearch
69.33
20%
-96
- C2 -
2CZ9
3
GAL1_PYRHO
A:
[2-350]
--
I
K
V
K
S
P
G
R
V
N
L
----
I
-----------
G
E
HTDYT
Y
G
Y
---
V
-
M
P
---
M
A
I
N
----
L
----
Y
T
K
I
E
A
E
K
--
H
G
-
E
--
V
I
L
Y
S
E
H
--------
F
----------
G
E
E
R
K
F
S
LNDLR
K
----
E
--
N
S
-
W
I
D
Y
V
K
G
I
F
W
V
L
K
E
S
D
Y
E
--
V
G
---
G
I
-----
K
G
R
V
S
G
N
L
P
L
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
-----------------
D
K
L
Y
N
L
K
L
D
S
L
S
K
V
L
L
A
K
K
A
------
E
------
N
EFVGVPCG
I
L
D
Q
F
A
-
V
V
F
G
REG
N
V
---
I
F
----
L
D
T
H
T
L
D
----
Y
E
Y
I
-
P
---
F
P
K
D
V
S
-----
I
----
L
V
F
Y
T
G
--
V
R
-----
S
S
E
-
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
GKGSSKEVREGEL
S
K
-------
L
--------------------------
P
P
L
H
R
K
F
F
G
Y
I
V
R
E
N
-
A
-
R
V
L
E
V
R
D
A
L
K
E
G
N
V
E
E
V
G
K
I
L
-
T
T
--
A
-
H
------
W
D
L
A
K
NY
E
---
V
---
S
C
K
E
L
----------
D
F
F
V
E
R
A
L
K
L
-
G
A
Y
G
A
R
L
T
G
A
G
FG
G
S
A
I
A
L
V
D
K
E
-
D
A
E
T
I
G
E
E
I
L
R
E
Y
L
K
R
F
P
-
W
---
K
A
R
H
F
I
V
E
P
-
S
D
G
V
G
I
-----------------
49
Fugue
66.98
25%
-79
- C2 -
1H72
3
KHSE_METJA
C:
[1-296]
MK
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
----V
F
G
---
L
C
L
K
-----EPYD
V
I
E
V
E
A
I
D
-
D
K
E
-
I
--
I
I
E
V
D
-
D
--------
K
----------
N
-----
I
-----
P
----
T
--
D
P
-
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
-----
F
N
-----IGKGV
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
ELASSG
A
------
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
N
Y
----
E
-
P
L
E
V
L
-
H
---
I
-
P
I
--DFKLD
I
----
L
I
A
I
P
N
IS
I
N
-
T
K
E
A
R
-
E
-
I
--
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
--------LIPNYFKIKE
E
V
K
D
K
-------
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
E-----------------------NTIRTEVGKGVEVV
7
PsiBlast_PDB
66.44
27%
-71
- C2 -
1H74
2
KHSE_METJA
A:
[3-268]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
P---
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
-
P
D
K
-------
N
V
A
G
I
-----
V
A
---
K
--------
K
M
I
D
D
F
N
I
G
K
G
V
K
I
T
---
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
----
N
-
Y
-
E
P
L
E
V
-
L
---
H
-
I
P
I
D
-----
F
K
L
D
I
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
K
G
V
E
V
V
-------------------
4
PsiBlast_PDB
65.73
27%
-70
- C2 -
1FWK
1
KHSE_METJA
A:
[3-268]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
P---
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
-
P
D
K
-------
N
V
A
G
I
-----
V
A
---
K
--------
K
M
I
D
D
F
N
I
G
K
G
V
K
I
T
---
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
----
N
-
Y
-
E
P
L
E
V
-
L
---
H
-
I
P
I
D
-----
F
K
L
D
I
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
K
G
V
E
V
V
-------------------
8
PsiBlast_PDB
65.71
27%
-72
- C2 -
1H73
2
KHSE_METJA
A:
[3-268]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
P---
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
-
P
D
K
-------
N
V
A
G
I
-----
V
A
---
K
--------
K
M
I
D
D
F
N
I
G
K
G
V
K
I
T
---
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
SSGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
----
N
-
Y
-
E
P
L
E
V
-
L
---
H
-
I
P
I
D
-----
F
K
L
D
I
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
K
G
V
E
V
V
-------------------
6
PsiBlast_PDB
65.25
27%
-71
- C2 -
1H72
3
KHSE_METJA
C:
[3-268]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
P---
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
-
P
D
K
-------
N
V
A
G
I
-----
V
A
---
K
--------
K
M
I
D
D
F
N
I
G
K
G
V
K
I
T
---
I
K
K
G
V
K
A
G
SGLGSSAASSAGTAYAI
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
----
N
-
Y
-
E
P
L
E
V
-
L
---
H
-
I
P
I
D
-----
F
KLDI
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
K
G
V
E
V
V
-------------------
25
HHSearch
65.17
20%
-63
- C2 -
3PYF
1
ISPE_MYCTU
A:
[6-300]
--
V
T
V
R
V
P
G
K
V
N
L
Y
L
A
V
G
-----------
D
R
RED--
G
Y
H
---
E
-
L
T
T
V
F
H
A
V
S
----
L
----
V
D
E
V
T
V
R
N
A
D
V
L
-
S
--
L
E
L
V
G
-
E
--------
G
A---------
D
-----
Q
-----
L
----
P
--
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
A
E
H
V
GR--
A
P
---
D
V
-----
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
-----------------
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
------
G
------
S
-----------
D
V
P
F
A
L
H
G
---
G
T
---
A
L
----
G
T
G
R
G
E
E
----
L
A
T
V
-
L
---
S
R
N
T
F
H
-----
W
----
V
L
A
F
A
D
--
S
G
-
L
L
T
S
A
-
V
-
Y
N
E
L
D
R
L
---------------------
R
E
-------
V
--------------------------
G
--------
D
-
P
P
R
L
-
G
-
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
N
E
--
M
--------
Q
A
A
A
---
V
---
S
---
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
-
G
A
L
A
G
I
V
S
G
S
G
--
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
-
A
----
G
-
V
---
C
R
T
V
R
V
A
T
G
P
V
P
G
A
R
V
V
----------------
5
PsiBlast_PDB
64.88
27%
-69
- C2 -
1FWL
-
KHSE_METJA
A:
[7-272]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
----
E
P---
Y
D
V
I
E
V
E
A
I
D
D
K
-
E
--
I
I
I
E
V
-
D
--------
D
----------
K
-----
N
-----
I
----
P
--
T
D
-
P
D
K
-------
N
V
A
G
I
-----
V
A
---
K
--------
K
M
I
D
D
F
N
I
G
K
G
V
K
I
T
---
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
--------
H
A
D
N
V
A
P
A
I
F
G
---
G
F
---
T
M
----
V
T
----
N
-
Y
-
E
P
L
E
V
-
L
---
H
-
I
P
I
D
-----
F
K
L
D
I
L
I
A
I
P
N
--
I
S
-
I
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
-------
L
--------------------------
K
--------
D
L
V
N
N
V
-
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
--
K
V
I
------
E
P
V
R
---
G
---
K
---
L
I
P
N
Y
----------
F
K
I
K
E
-
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
K
E
E
-
F
I
D
E
V
E
N
I
L
R
D
-
Y
----
Y
-
E
---
N
T
I
R
T
E
V
G
K
G
V
E
V
V
-------------------
30
HHSearch
64.68
15%
-77
- C2 -
1WUU
3
GALK1_HUMAN
A:
[37-397]
--
L
A
V
S
A
P
G
R
V
N
L
----
I
-----------
G
E
HTDYN
Q
G
L
---
V
-
L
P
---
M
A
L
E
----
L
----
M
T
V
L
V
G
S
P
R
K
D
G
-
L
--
V
S
L
L
T
T
S
EG------
A
DEPQ
R
L
Q
F
P
L
P
-----
T
AQ
R
S
-
L
E
PG-
T
--
P
R
-
W
A
N
Y
V
K
G
V
I
Q
Y
Y
P
A
A
P----
L
P
---
G
F
-----
S
A
V
V
V
S
S
V
P
L
G
G
G
L
S
S
S
A
S
L
E
V
A
T
Y
T
F
L
-----------------
Q
Q
L
C
P
D
S
G
T
I
A
A
R
A
Q
V
C
Q
Q
A
------
E
------
H
S
FAGMPCG
I
M
-
D
Q
F
I
S
L
M
G
---
Q
K
GHA
L
L
----
I
D
C
R
S
L
E
-
T
-
S
L
V
P
L
-
S
---
D
-
P
K
L
A
-----
V
----
L
I
T
N
S
N
--
V
R
-
H
--
A
S
-
S
E
Y
P
V
R
R
R
Q
---------------------
C
E
E
V
A
R
A
L
G
K
ESLREVQ
L
E
E
L
E
A
A
RDLVS
K
E
G
F
R
R
A
R
--------
H
V
V
G
E
I
-
R
-
R
T
A
Q
A
A
A
A
L
R
R
G
D
Y
R
A
F
G
R
L
M
V
E
S
----
H
------
R
S
L
R
---
D
DYE
V
---
S
C
P
E
L
----------
D
Q
L
V
E
A
A
L
A
V
P
G
V
Y
G
S
R
M
T
G
G
G
F
G
G
C
T
V
T
L
L
E
A
S
-
A
A
P
H
A
M
R
H
I
Q
E
H
Y
----
G
-
G
---
T
A
T
F
Y
L
S
Q
A
-
A
D
G
A
K
V
L
C
L
--------------
40
HHSearch
64.00
19%
-76
- C2 -
3QT5
-
?
A:
[5-326]
--
G
K
A
R
A
H
T
N
I
A
L
----
I
KYWGKADETYI
I
P
-----
M
N
N
---
S
-
L
S
---
V
T
L
D
----
R
F
---
Y
T
E
T
K
V
T
F
D
P
D
F
T
E
--
D
C
L
I
L
-
N
--------
G
----------
N
-----
E
-----
V
----
N
--
A
K
-
E
K
E
K
I
Q
N
Y
M
N
I
V
R
D
L
A
GN--
R
L
---
H
A
-----
R
I
E
S
E
N
Y
V
P
T
A
A
G
L
A
S
S
A
S
A
Y
A
A
L
A
A
A
C
-----------------
N
E
A
L
S
L
N
L
S
D
T
D
L
S
R
L
A
R
R
G
------
S
------
G
-----------
S
A
S
R
S
I
F
G
---
G
F
---
A
E
----
W
E
K
G
H
D
D
L
T
S
Y
A
H
G
I
-
N
SNG
W
E
K
D
L
S
M
I
---
F
----
V
V
I
N
N
Q
--
S
K
-
K
-
S
R
S
-
G
-
M
S
L
T
R
D
T
---------------------
S
R
-------
F
Y
-------------------------
Q
--------
Y
W
L
D
H
V
-
D
E
D
L
N
E
A
K
E
A
V
K
N
Q
D
F
Q
R
L
G
E
V
I
E
A
N
G
L
R
M
H
A
T
N
L
G
A
Q
P
P
F
---
T
---
Y
LV
Q
E
S
Y
D
A
----------
M
A
I
V
E
Q
C
R
K
A
-
N
L
P
C
Y
F
T
M
D
A
G
--
P
N
V
K
V
L
V
E
K
K
-
N
K
Q
A
V
M
E
Q
F
L
K
-
V
----
F
-
D
---
E
S
K
I
I
A
S
D
I
I
S
S
G
V
E
I
I
K
---------------
43
HHSearch
61.69
21%
-64
- C2 -
1KKH
2
MVK_METJA
A:
[6-315]
--
M
I
I
E
T
P
S
K
V
I
L
----
F
-----------
G
E
H
A
V
V
Y
G
Y
R
---
A
-
I
S
---
M
A
I
D
----
L
----
T
S
T
I
E
I
K
E
T
Q
E
D
-
E
--
I
I
L
N
L
N
D
LN
K
S
L
G
L
N
L
----------
N
-----
E
-----
I
KNIN
P
NN
F
G
-
D
F
K
Y
C
L
C
A
I
K
N
T
L
D
Y
L
NIEP
K
T
---
G
F
-----
K
I
N
I
S
S
K
I
P
I
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
-----------------
S
G
F
Y
N
K
E
L
K
D
D
E
I
A
K
L
G
Y
M
V
------
E
------
K
E
I
Q
GKAS-
I
T
D
-
T
S
T
I
T
Y
K
---
G
I
---
L
E
----
I
K
N
N
K
F
R
-
K
-
I
K
G
E
F
E
E
---
F
L
K
N
C
K
-----
F
----
L
I
V
Y
A
E
--
K
R
K
K
K
T
A
E
-
L
-
V
N
E
V
A
K
I
---------------------
E
N
-------
K
--------------------------
D
--------
E
I
F
K
E
I
-
D
---
K
V
I
D
E
A
L
K
I
K
N
K
E
D
F
G
K
L
M
-
T
K
--
N
-
H
------
E
L
L
K
---
K
---
L
NI-
S
T
P
K
L
----------
D
R
I
V
D
I
G
N
R
F
-
G
-
F
G
A
K
L
T
G
A
G
GG
G
C
V
I
I
L
V
N
E
E
-
K
E
K
E
L
L
K
E
L
N
K
-
E
----------
D
V
R
I
F
N
C
R
M
M
N
----------------------
31
HHSearch
60.05
18%
-77
- C2 -
2V8P
5
ISPE_AQUAE
A:
[5-270]
--
I
K
V
L
S
P
A
K
I
N
L
----
G
L
W
V
L-------
G
R
LPS--
G
Y
H
E
I
L
T
-
L
Y
---
Q
E
I
P
----
F
----
Y
D
E
I
Y
I
R
E
--
G
V
----
L
R
V
E
T
-
N
--------
I
----------------
G
-----
I
-------
P
Q
-
E
E
N
L
V
Y
K
G
L
R
E
F
E
R
I
T
GI--
E
I
---
N
Y
-----
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
-----------------
N
E
L
L
G
S
P
L
S
E
E
E
L
R
E
L
V
G
S
I
------
S
------
A
-----------
D
A
P
F
F
L
L
G
---
K
S
---
A
I
----
G
R
G
K
G
E
V
----
L
E
P
V
-
E
---
T
E
I
S
G
K
-----
I
----
T
L
V
I
P
Q
--
V
S
-
S
S
T
G
R
-
V
-
Y
S
S
L
R
E
E
---------------------
H
F
-------
V
---------------------------------------
T
P
-
E
-
Y
A
E
E
K
I
Q
R
I
I
S
G
E
V
E
E
I
E
N
V
L
-
G
D
--
I
-----------
A
---
R
---
E
---
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
-
G
-
F
K
P
F
V
S
G
S
G
--
S
T
V
Y
F
F
G
G
A
S
-
E
--
E
L
K
K
A
A
K
M
-
R
----------
G
W
K
V
V
E
L
E
L
------------------------