@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1187: (2015-12-06 )
MTIKIALLGFGTVAKGIPYLLKENQHKLLSLEGEDIVIDKVLVRDNESRQRFINQGFTYNFVTEINTILQDPQIDIVVELMGGIEPAKTYLSQALGFGKHIVTANKDLIALHGKELMDLADARGLALFYEGAVAGGIPILRTLSHSFASDKMTRLLGILNGTSNFMLTKMFEEGWSYEQALKKAQELGYAESDPTNDVEGIDTAYKATILSQFGFGMPIDFDDVNYKGISSIRSEDVEVAQEMGFAIKLVADLRETPTGISVDVSPTLISQEHPLAAVNHVMNAVFIESIGIGQSLFYGPGAGQNPTATSVLADIIDISRSIRSQIKIKPMNTYHCPCRLSMQSDIFNEYYLAISLRNAEDSDTLGRYFEQENIGLKNVIEKALDDKQQEIYVLTDEVSQEKITQFIEEFPESGVIQLINVFKVIGG
Atome Classification :
(20 SA)
--.....-...-.10........20........30-.--------------..-----------.....40....---------....--------50------.--..------..-...----60........70---------.........-----80..-..---.----...90...-.....-100....-.-..-110.....-...120...--....-..130.......140......-.-150.-......160.......-170---.---......180.......190.......200.......-210........220........230...---------------------....240.......250.-......260-----------------.........270...-...-.280.....------..290.-....-...300.....-..310.......320......-.330....----...340.......350.......360...----....370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
T
I
K
I
-
A
L
L
-G
F
G
T
V
A
KG
I
P
Y
L
L
KENQ
H
K
L
L
SL-E--------------GE-----------
D
I
V
I
D
K
V
L
VRD---------
N
E
S
R
--------
Q
R
------
F
--
I
N------QG-F
T
Y
----
N
F
V
T
E
I
N
T
I
LQ----------DPQ
I
D
I
V
V
E
-----
L
MGG-I
E
---
P
----
A
K
T
Y
L
S
Q
A
-LGFG
K
-
H
I
VTANK-
D
-
L
I
-
A
-L
H
G
K
E
L
-
M
D
L
A
--DAR--
G
L
A
L
-
F
YEGAVAG
G
I
P
I
L
R
T
L
S
H
S
F
A
-
S
-
D
K
M
T
-
R
L
L
G
I
LNGTSN
F
M
L
T
K
-
M
F
E
---E---GW
S
Y
E
Q
A
L
K
K
A
Q
ELGYAESDPTNDVE
G
I
D
T
A
Y
K
A
T
I
-
L
S
-QFGFGMPID-FDDVN
Y
K
G
I
S
S
I
R
S
E
---------------------
D
V
E
V
A
Q
EMG
F
A
I
K
L
V
A
D
L
-RETPT
G
I
-------------------
S
V
DVSPTLISQEH
P
L
-
A
A
V
-
N
H
V
M
N
A
V
F
I
------
E
SIG-I-GQSL-FYGPGAGQNP
T
-
A
T
S
V
L
A
D
I
I
D
I
S
R
S
I
R
S
Q
I
K
I-KPMNTYHC----P
C
R
L
S
M
Q
S
D
I
F
N
E
Y
Y
L
A
I
S
LRNAED
S
D
T
L
----
G
R
Y
F
E
Q
ENI
G
L
K
N
V
I
E
K
ALDDKQ
Q
E
I
Y
V
LTDEV
S
Q
E
K
I
T
Q
F
I
E
EFPES
G
V
I
Q
L
I
N
V
F
K
V
IGG
37
HHSearch
98.97
35%
-107
* C1 *
3MTJ
3
?
A:
[9-440]
--
K
P
I
H
V
-
G
L
L
-
G
L
G
T
V
G
G
G
T
L
T
V
L
R
R
N
A
E
E
I
T
R
R
-
A
--------------
G
R
-----------
E
I
R
V
V
R
A
A
V
R
N
---------
L
D
K
A
--------
E
A
------
L
--
A
G
----------
G
L
----
P
L
T
T
N
P
F
D
V
V
D
----------
D
P
E
I
D
I
V
V
E
-----
L
I
G
G
-
L
E
---
P
----
A
R
E
L
V
M
Q
A
-
I
A
N
G
K
-
H
V
V
T
A
N
K
-
H
-
L
V
-
A
-
K
Y
G
N
E
I
-
F
A
A
A
--
Q
A
K
--
G
V
M
V
-
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
T
-
A
-
N
R
I
E
-
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
-
M
R
D
---
K
---
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
-
L
S
-
A
I
A
F
G
I
P
M
Q
-
F
E
R
A
Y
T
E
G
I
S
Q
L
T
R
E
---------------------
D
V
R
Y
A
E
E
L
G
Y
R
I
K
L
L
G
I
A
-
R
R
A
E
N
G
I
-------------------
E
L
R
V
H
P
T
L
I
P
E
R
R
L
I
-
A
N
V
-
D
G
A
M
N
A
V
L
V
------
K
G
D
A
-
V
-
G
P
T
L
-
Y
Y
G
A
G
A
G
S
E
P
T
-
A
S
A
V
V
A
D
L
V
D
V
T
R
L
H
T
A
D
P
H
H
R
V
P
H
L
A
F
Q
P
DQLA
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
L
R
A
F
----
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
K
----
E
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
A
L
D
A
V
A
G
K
V
M
R
I
R
L
E
D
60
Fugue
95.06
35%
-102
- C1 -
4PG7
9
?
A:
[20-446]
H
M
K
K
L
N
I
-
A
L
L
-
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
-
L
--------------
N
K
-----------
D
I
V
I
K
H
I
L
V
R
D
K--------
S
K
K
R
--------
P
L
------
N
--
I
S
------
Q
----
Y
----
H
L
T
E
D
V
N
E
I
L
N
----------
D
D
S
L
D
I
I
V
E
-----
V
M
G
G
-
I
E
---
P
----
T
V
D
W
L
R
T
A
-
L
K
N
K
K
-
H
V
I
T
A
N
K
-
D
-
L
L
-
A
-
V
H
L
K
L
L
-
E
D
L
A
--
E
E
N
--
G
V
A
L
-
K
F
E
A
S
V
A
G
G
-------------
P
-
N
N
I
S
-
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
-
M
T
K
---
E
---
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
-
T
S
-
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
-
I
Y
E
N
G
K
V
-------------------
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
-
A
A
V
-
E
D
E
Y
N
A
I
Y
V
------
I
G
D
A
-
V
-
G
D
T
M
-
F
Y
G
K
G
A
G
S
L
A
T
-
G
S
A
V
V
S
D
L
L
N
V
A
L
F
F
E
S
T
L
P
-------
P
H
F
----
E
L
K
T
D
K
T
R
E
M
E
K
S
N
F
F
V
V
V
N
H
V
K
G
S
I
E
N
F
----
E
N
E
L
K
A
I
-
L
P
F
H
R
S
L
R
V
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
G
------
L
E
S
S
P
E
E
L
I
T
K
H
G
Y
E
V
D
K
V
Y
P
V
E
G
V
38
HHSearch
85.69
34%
-103
- C1 -
3DO5
3
?
A:
[2-325]
---
M
I
K
I
-
A
I
V
-
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
R
E
E
I
E
K
A
----------------
I
G
-----------
E
F
K
V
T
A
V
A
D
S
K
---------
S
S
I
S
--------
G
D
------
F
S
L
V
E
A
L
R
M
K
R
E
T
-
G
M
L
----
R
D
D
A
K
A
I
E
V
V
R
----------
S
A
D
Y
D
V
L
I
E
-----
A
S
V
T
R-----
E
----
G
V
N
Y
I
R
E
A
-
L
K
R
G
K
-
H
V
V
T
S
N
K
-
G
-
P
L
-
V
-
A
E
F
H
G
L
-
M
S
L
A
--
E
R
N
--
G
V
R
L
-
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
A
-
L
-
C
E
I
E
-
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
-
M
E
E
---
E
---
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
-
I
A
-
N
T
-
I
G
V
K
A
S
-
Y
E
D
V
E
V
T
G
I
T
Q
I
T
P
E
---------------------
A
F
Q
V
A
A
E
K
G
Y
T
I
R
L
I
A
E
V
-
S
R
----
E
-------------------
K
L
K
V
S
P
R
L
V
P
F
H
H
P
L
-
A
-
I
-
K
G
T
M
N
A
A
M
F
------
K
T
D
T
-
A
-
G
S
I
F
-
V
A
G
R
G
A
G
K
E
E
T
-
A
S
A
I
L
S
D
L
Y
E
I
Y
A
G
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.57
40%
-99
- C1 -
3MTJ
3
?
A:
[30-343]
-------------------------
R
R
N
A
E
E
I
T
R
R
-
A
--------------
G
R
-----------
E
I
R
V
V
R
A
A
V
R
----------
N
L
D
K
--------
A
E
------
A
--
L
A
------
G
G
-
L
P
------
L
T
T
N
P
F
D
V
V
D
----------
D
P
E
I
D
I
V
V
E
-----
L
I
G
G
-
L
E
---
P
----
A
R
E
L
V
M
Q
A
-
I
A
N
G
K
-
H
V
V
T
A
N
K
-
H
-
L
V
-
A
-
K
Y
G
N
E
I
-
F
A
A
A
--
Q
A
K
--
G
V
M
V
-
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
T
-
A
-
N
R
I
E
-
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
-
M
R
D
---
K
---
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
-
L
S
-
A
I
A
F
G
I
P
M
Q
-
F
E
R
A
Y
T
E
G
I
S
Q
L
T
R
E
---------------------
D
V
R
Y
A
E
E
L
G
Y
R
I
K
L
L
G
I
A
-
R
R
A
E
N
G
I
-------------------
E
L
R
V
H
P
T
L
I
P
E
R
R
L
I
-
A
N
V
-
D
G
A
M
N
A
V
L
V
------
K
G
D
A
-
V
-
G
P
T
L
-
Y
Y
G
A
G
A
G
S
E
P
T
-
A
S
A
V
V
A
D
L
V
D
V
T
R
-------
L
-
H
T
A
D
P
H
H
R
----
V
P
H
L
A
F
Q
P
D
Q
L
A
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
----
L
R
A
F
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
K
E
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
A
L
D
A
V
A
G
K
59
Fugue
83.21
33%
-88
- C1 -
2EJW
3
?
A:
[1-331]
-M
E
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
--------
R
A
------
I
--
P
Q
------
E
L
-
L
R
-----------
A
E
P
F
D
----------
L
L
E
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
E
G
--
L
--
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
-
E
---
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
-------------------------------------------------------------------------------
E
E
G
S
P
W
P
G
V
------------
42
HHSearch
82.53
34%
-96
- C1 -
2EJW
3
?
A:
[2-311]
--
E
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
-
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
--------
R
A
------
I
--
P
-----------
Q
-----
E
L
L
R
A
--
E
P
F
D
----------
L
L
E
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
E
G
----
L
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
E
T
L
R
--
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
E
----
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
E
----
E
G
S
P
W
P
G
V
---------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.29
35%
-104
- C1 -
3DO5
3
?
A:
[3-322]
----
I
K
I
-
A
I
V
-
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
R
E
E
I
E
K
A
-
I
--------------
G
E
FKVT
A
V
A
D
S
K
S
S
I
S
G
D
F
S
L
V
------------
E
A
L
--------
R
M
------
K
--
R
E
------
T
G
-
M
L
R
----
D
D
A
K
A
I
E
-
V
V
R
----------
S
A
D
Y
D
V
L
I
E
ASVTR----------
E
----
G
V
N
Y
I
R
E
A
-
L
K
R
G
K
-
H
V
V
T
S
N
K
-
G
P
L
V
-
A
E
F
H
G
--
L
-
M
S
L
A
--
E
R
N
--
G
V
R
L
-
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
A
-
L
-
C
E
I
E
-
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
-
M
E
E
---
E
---
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
-
I
A
-
N
T
-
I
G
V
K
A
S
-
Y
E
D
V
E
V
T
G
I
T
Q
I
T
P
E
---------------------
A
F
Q
V
A
A
E
K
G
Y
T
I
R
L
I
A
E
V
S
R
E
------------------------
K
L
K
V
S
P
R
L
V
P
F
H
H
P
L
--
A
I
-
K
G
T
M
N
A
A
M
F
------
K
T
D
T
-
A
-
G
S
I
F
-
V
A
G
R
G
A
G
K
E
E
T
-
A
S
A
I
L
S
D
L
Y
E
I
Y
A
G
-------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.04
36%
-108
- C1 -
2EJW
4
?
E:
[3-282]
---
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
-
S
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
-
K
--------
P
R
------
A
--
I
P
------
Q
E
-
L
-------
L
R
A
E
P
F
D
L
L
E
-------------
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
-
E
--
G
L
-
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
-
E
---
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
E
----
E
G
S
P
W
P
G
V
---------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.49
36%
-108
- C1 -
2EJW
3
?
B:
[3-282]
---
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
-
S
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
-
K
--------
P
R
------
A
--
I
P
------
Q
E
-
L
-------
L
R
A
E
P
F
D
L
L
E
-------------
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
-
E
--
G
L
-
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
-
E
---
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
E
----
E
G
S
P
W
P
G
V
---------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.21
36%
-107
- C1 -
2EJW
3
?
A:
[3-282]
---
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
-
S
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
-
K
--------
P
R
------
A
--
I
P
------
Q
E
-
L
-------
L
R
A
E
P
F
D
L
L
E
-------------
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
-
E
--
G
L
-
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
-
E
---
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
E
----
E
G
S
P
W
P
G
V
---------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.62
36%
-105
- C1 -
2EJW
3
?
F:
[3-282]
---
A
L
K
I
-
A
L
L
-
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
-
S
A
-
F
--------------
G
V
-----------
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
-
K
--------
P
R
------
A
--
I
P
------
Q
E
-
L
-------
L
R
A
E
P
F
D
L
L
E
-------------
A
D
L
V
V
E
-----
A
M
G
G
-
V
E
---
A
----
P
L
R
L
V
L
P
A
-
L
E
A
G
I
-
P
L
I
T
A
N
K
-
A
-
L
L
-
A
-
E
A
W
E
S
L
-
R
P
F
A
--
E
-
E
--
G
L
-
I
-
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
-
S
E
L
L
-
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
-
M
-
E
---
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
-
L
A
-
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
-
F
G
E
G
G
R
W
-------------------
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
-
A
R
A
-
R
G
--
N
A
L
W
V
------
R
A
R
P
-
L
-
G
E
A
F
-
V
T
G
P
G
A
G
G
G
A
T
-
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
-
P
R
A
R
P
P
L
E
----
E
G
S
P
W
P
G
V
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.56
28%
-92
- C1 -
4XB1
4
?
A:
[17-325]
--
M
K
V
N
I
-
S
I
F
-
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
-
K
S
R
I
F
G
V
-
E
L
N
V
I
S
I
T
D
RS
G
T
I
W
G
D
-----------
F
D
L
L
E
A
K
E
V
K
E
---------
S
T
G
K
--------
L
S
------
N
--
I
G
------
D
Y
-
E
V
Y
----
N
F
S
P
Q
--
E
L
V
E
----------
E
V
K
P
N
I
L
V
D
-----
V
S
S
W
-
D
E
---
A
----
H
E
M
Y
-
K
V
A
-
L
G
E
G
I
-
S
V
V
T
S
N
K
-
P
-
P
I
-
A
-
N
Y
Y
D
E
L
-
M
N
L
A
--
K
E
N
--
N
A
G
I
-
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
-
E
N
I
K
-
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
-
M
-
S
---
E
---
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
-
L
H
-
W
V
S
Y
G
E
P
P
E
-
E
E
E
--
R
L
G
I
R
E
V
R
D
------------------------------
A
R
N
V
R
L
V
A
Q
V
-
S
K
G
-----------------------
K
I
S
V
K
P
R
K
L
S
S
D
N
P
L
--
L
V
-
E
G
V
Q
N
A
A
V
I
------
R
T
N
N
-
L
-
G
E
V
I
-
L
K
G
P
G
G
G
G
R
V
T
-
A
S
G
V
F
T
D
I
I
K
A
T
L
K
F
P
N
L
R
--------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.10
28%
-94
- C1 -
4XB2
3
?
A:
[17-325]
--
M
K
V
N
I
-
S
I
F
-
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
-
K
S
R
I
F
G
V
-
E
L
N
V
I
S
I
T
D
RS
G
T
I
W
G
D
-----------
F
D
L
L
E
A
K
E
V
A
E
---------
S
T
G
K
--------
L
S
------
N
--
I
G
------
D
Y
-
E
V
Y
----
N
F
S
P
Q
--
E
L
V
E
----------
E
V
K
P
N
I
L
V
D
-----
V
S
S
W
-
D
E
---
A
----
H
E
M
Y
-
K
V
A
-
L
G
E
G
I
-
S
V
V
T
S
N
K
-
P
-
P
I
-
A
-
N
Y
Y
D
E
L
-
M
N
L
A
--
K
E
N
--
N
A
G
I
-
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
-
E
N
I
K
-
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
-
M
-
S
---
E
---
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
-
L
H
-
W
V
S
Y
G
E
P
P
E
-
E
E
E
--
R
L
G
I
R
E
V
R
D
------------------------------
A
R
N
V
R
L
V
A
Q
V
-
S
K
G
-----------------------
K
I
S
V
K
P
R
K
L
S
S
D
N
P
L
--
L
V
-
E
G
V
Q
N
A
A
V
I
------
R
T
N
N
-
L
-
G
E
V
I
-
L
K
G
P
G
G
G
G
R
V
T
-
A
S
G
V
F
T
D
I
I
K
A
T
L
K
F
P
N
L
R
--------------------------------------------------------------------------------------------------------------
41
HHSearch
74.10
22%
-91
- C1 -
3C8M
4
?
A:
[5-328]
--
K
T
I
N
L
-
S
I
F
-
G
L
G
N
V
G
L
N
L
L
R
I
I
R
S
F
N
E
E
--
N
R
-
L
--------------
G
L
-----------
K
F
N
V
V
F
V
A
D
S
L
---------
H
S
Y
Y
--------
N
E
RID
I
G
K
V
--
I
S
Y
K
----
E
K
-
G
S
L
DSLE
Y
E
S
I
S
A
S
E
A
L
A
-----------
R
D
F
D
I
V
V
D
-----
A
T
P
A
-
S
A
DG
K
K
----
E
L
A
F
Y
K
E
T
-
F
E
N
G
K
-
D
V
V
T
A
N
K
-
S
-
G
L
-
A
-
N
F
W
P
E
I
-
M
E
Y
A
--
R
S
N
--
N
R
R
I
-
R
Y
E
A
T
V
A
G
G
V
P
L
F
S
F
I
D
Y
S
V
L
-
P
-
S
R
I
K
-
K
F
R
G
I
V
S
L
T
I
N
Y
F
I
R
E
-
L
A
N
-------
K
R
E
F
D
D
V
L
S
E
A
T
K
L
G
I
V
E
K
N
Y
K
D
D
L
T
G
L
D
A
A
R
K
S
V
I
-
L
C
-
N
H
L
Y
G
S
S
Y
R
-
L
S
D
V
F
Y
E
G
I
L
-
Q
------------------------
D
R
----
S
F
G
K
N
E
R
L
V
T
E
T
-
G
I
V
N
G
K
P
-------------------
S
A
E
S
R
I
K
S
L
D
S
N
D
Y
L
-
L
T
L
-
G
K
G
S
L
G
Y
Q
L
------
Q
T
D
T
-
N
-
G
T
L
N
-
V
S
D
L
Y
D
G
P
Y
E
T
-
A
G
A
V
M
N
D
L
V
I
L
S
M
--------------------------------------------------------------------------------------------------------------------
40
HHSearch
73.69
24%
-93
- C1 -
3ING
8
?
A:
[3-323]
--
K
E
I
R
I
-
I
L
M
-
G
T
G
N
V
G
L
N
V
L
R
I
I
D
A
S
N
R
R
---
R
-----------------
F
-----------
S
I
K
V
V
G
V
S
D
S
R
---------
S
Y
A
S
G
RNLD
I
--
S
S
------
I
I
-
S
N
K
E
K
---
T
G
R
I
S
D
----
R
A
F
S
G
P
E
D
L
M
-----------
G
E
A
A
D
L
L
V
D
-----
C
T
P
A
-
S
----
R
DG
V
R
E
Y
S
L
Y
R
M
A
-
F
E
S
G
M
-
N
V
V
T
A
N
K
-
S
-
G
L
-
A
-
N
K
W
H
D
I
-
M
D
S
A
--
N
Q
N
--
S
K
Y
I
-
R
Y
E
A
T
V
A
G
G
V
P
L
F
S
V
L
D
Y
S
I
L
-
P
-
S
K
V
K
-
R
F
R
G
I
V
S
S
T
I
N
Y
V
I
R
N
-
M
A
N
-------
G
R
S
L
R
D
V
V
D
D
A
I
K
K
G
I
A
E
S
N
P
Q
D
D
L
N
G
L
D
A
A
R
K
S
V
I
-
L
V
-
N
H
I
F
G
T
E
Y
T
-
L
N
D
V
E
Y
S
G
V
D
E
R
S
------------------------------
Y
N
A
N
D
R
L
V
T
E
V
-
Y
V
D
D
R
R
P
-------------------
V
A
V
S
R
I
I
S
L
N
K
D
D
F
L
-
M
S
I
-
G
M
D
G
L
G
Y
Q
I
------
E
T
D
S
-
N
-
G
T
V
N
-
V
S
D
I
Y
D
G
P
Y
E
T
-
A
G
A
V
V
N
D
I
L
L
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
61
Fugue
68.92
22%
-82
- C1 -
3ING
8
?
A:
[3-323]
--
K
E
I
R
I
--
I
L
M
G
T
G
N
V
G
L
N
V
L
R
I
I
D
A
S
N
R
R
--------------------
R
F
-----------
S
I
K
V
V
G
V
S
D
S
R
---------
S
Y
A
S
--------
G
R
------
N
--
L
D
------
I
S
-
S
I
I
----
S
N
K
E
K
T
G
R
I
S
D
RAFSGPEDLM
G
E
A
A
D
L
L
V
D
-----
C
T
P
A
S
R
D
---
G
----
V
R
E
Y
S
L
Y
R
M
A
F
E
S
G
M
N
V
V
T
A
N
K
-
S
-
G
L
-
A
-
N
K
W
H
D
I
M
D
-
S
A
--
N
Q
N
--
S
K
Y
I
-
R
Y
E
A
T
V
A
G
G
V
P
L
F
S
V
L
D
Y
S
I
L
-
P
-
S
K
V
K
-
R
F
R
G
I
V
S
S
T
I
N
Y
V
I
R
N
M
A
-----
N
---
G
R
S
L
R
D
V
V
D
D
A
I
K
K
G
I
A
E
S
N
P
Q
D
D
L
N
G
L
D
A
A
R
K
S
V
I
-
L
V
-
N
H
I
F
G
T
E
Y
T
-
L
N
D
V
E
Y
S
G
V
D
E
R
------------------------------
S
Y
N
A
N
D
R
L
V
T
E
V
-
Y
V
D
D
R
R
P
-------------------
V
A
V
S
R
I
I
S
L
N
K
D
D
F
L
M
S
I
G
M
D
--
G
L
G
Y
Q
I
------
E
T
D
S
-
N
-
G
T
V
N
-
V
S
D
I
Y
D
G
P
Y
E
T
-
A
G
A
V
V
N
D
I
L
L
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
39
HHSearch
67.52
21%
-87
- C1 -
1EBF
2
DHOM_YEAST
A:
[3-357]
--
K
V
V
N
V
-
A
V
I
-
G
A
G
V
V
G
S
A
F
L
D
Q
L
L
A
M
K
S
T
I
-------------------
T
Y
-----------
N
L
V
L
L
A
E
A
E
R
S
---------
L
I
S
K
DFSPLNVG
S
D
------
W
--
K
A
A
-----
L
A
-
A
S
T
----
T
K
T
L
P
L
D
D
L
I
A
H
L
K
T
------
S
P
K
P
V
I
L
V
D
-----
N
T
S
S
--
A
---
Y
----
I
A
G
F
Y
T
K
F
-
V
E
N
G
I
-
S
I
A
T
P
N
K
-
K
-
A
F
-
S
-
S
D
L
A
T
W
-
K
A
L
F
SN
K
P
T
--
N
G
F
V
-
Y
H
E
A
T
V
G
A
G
L
P
I
I
S
F
L
R
E
I
I
Q
T
G
-
D
E
V
E
-
K
I
E
G
I
F
S
G
T
L
S
Y
I
F
N
E
-
F
S
T
SQA
N
---
D
V
K
F
S
D
V
V
K
V
A
K
K
L
G
Y
T
E
P
D
P
R
D
D
L
N
G
L
D
V
A
R
K
V
T
I
-
V
G
-
R
I
S
-
G
V
E
V
E
S
P
T
S
F
P
V
Q
S
L
I
P
K
P
L
E
SVKS
A
D
E
F
L
E
K
L
S
DYD
K
D
L
T
Q
L
K
K
E
A
A
T
E
N
K
V
L
R
F
I
G
K
V
-
D
V
A
--
T
K
-------------------
S
V
S
V
G
I
E
K
Y
D
Y
S
H
P
F
-
A
S
L
-
K
G
S
D
N
V
I
S
I
------
K
T
K
R
Y
T
-
N
P
V
V
-
I
Q
G
A
G
A
G
A
A
V
T
-
A
A
G
V
L
G
D
V
I
K
I
A
Q
R
L
------------------------------------------------------------------------------------------------------------------
62
Fugue
62.41
20%
-75
- C1 -
1EBF
2
DHOM_YEAST
A:
[1-358]
ST
K
V
V
N
V
-
A
V
I
-
G
A
G
V
V
G
S
A
F
L
D
Q
L
L
A
M
K
S
T
I
T
Y
N
-
L
--------------
V
L
-----------
L
A
E
A
E
R
S
L
I
S
K
DFSPLNVGS
D
W
K
A
--------
A
L
------
A
--
A
S
------
T
T
-
K
T
L
----
P
L
D
D
L
I
A
H
L
K
T
----------
S
P
K
P
V
I
L
V
D
-----
N
T
S
S
-
A
Y
---
I
----
A
G
-
F
Y
T
K
F
-
V
E
N
G
I
-
S
I
A
T
P
N
K
-
K
-
A
F
-
S
-
S
D
L
A
T
W
-
K
A
L
F
--
S
N
K
PT
N
G
F
V
-
Y
H
E
A
T
V
G
A
G
L
P
I
I
S
F
L
R
E
I
I
Q
-
T
G
D
E
V
E
-
K
I
E
G
I
F
S
G
T
L
S
Y
I
F
N
E
-
F
S
T
---
S
QAN
D
V
K
F
S
D
V
V
K
V
A
K
K
L
G
Y
T
E
P
D
P
R
D
D
L
N
G
L
D
V
A
R
K
V
T
I
-
V
G
-
R
I
S
G
V
E
V
E
S
-
P
T
S
F
P
V
Q
S
L
I
P
K
P
L
E
---------------------
S
V
K
S
A
D
E
F
L
E
K
L
S
D
Y
D
K
D
-
L
T
Q
L
K
K
E
A
A
T
E
N
K
V
L
R
F
I
G
K
V
D
VATK
S
V
S
V
G
I
E
K
Y
D
Y
S
H
P
F
-
A
S
L
-
K
G
S
D
N
V
I
S
I
------
K
T
K
R
-
Y
T
N
P
V
V
-
I
Q
G
A
G
A
G
A
A
V
T
-
A
A
G
V
L
G
D
V
I
K
I
A
Q
R
L
------------------------------------------------------------------------------------------------------------------
67
Fugue
57.76
16%
-56
- C1 -
2O4U
9
DHDH_MACFA
X:
[2-332]
---
A
L
R
W
-
G
I
V
-
S
V
G
L
I
S
S
D
F
T
A
V
L
Q
-------
T
L
-
P
--------------
R
S
-----------
E
H
Q
V
V
A
V
A
A
R
D
---------
L
S
R
A
--------
K
E
------
F
--
A
Q
------
K
H
-
D
I
P
----
K
A
Y
G
S
Y
E
E
L
A
K
----------
D
P
N
V
E
-
V
A
Y
-----
V
G
T
Q
-
H
P
---
Q
----
H
K
A
A
V
M
L
C
-
L
A
A
G
K
-
A
V
L
C
E
K
P
M
G
-
V
N
-
A
-
A
E
V
R
E
M
-
V
T
E
A
--
R
S
R
--
G
L
-
F
-
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
-
Q
-
G
T
L
G
-
D
L
R
V
A
R
A
E
F
G
K
N
L
----------------
T
H
V
P
R
A
V
D
W
A
Q
A
G
G
A
L
L
D
L
--------
G
I
Y
C
V
Q
F
-
I
S
-
M
V
F
G
G
Q
K
P
E
-------------------------------------------------
K
I
S
V
M
G
-
R
R
H
E
T
G
V
-------------------
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
-
G
S
F
-
T
C
S
I
T
A
----------------------------
Q
L
S
N
-
T
A
S
V
S
G
T
--------
K
G
M
A
Q
L
-
L
--
N
P
C
W
C
----
P
T
E
L
V
V
K
G
---
E
H
K
E
F
L
L
P
P
V
P
K
N
C
N
F
D
N
----
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
--
G
L
K
E
S
P
V
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
--
G
V
T
F
P
Q
D
-------
64
Fugue
52.25
18%
-61
- C1 -
3FD8
2
?
A:
[3-350]
---
L
T
V
K
M
G
F
I
-
G
F
G
K
S
A
N
R
Y
H
L
P
Y
---------
V
M
I
--------------
R
E
-----------
T
L
E
V
K
T
I
F
D
L
H
---------
V
N
E
K
--------
A
A
------
A
--
P
F
------
K
E
-
K
G
V
----
N
F
T
A
D
L
N
E
L
L
T
----------
D
P
E
I
E
L
I
T
------
I
C
T
P
-
A
H
---
T
----
H
Y
D
L
A
K
Q
A
-
I
L
A
G
K
-
S
V
I
V
E
K
P
-
F
-
C
D
T
L
-
E
H
A
E
E
L
-
F
A
L
G
--
Q
E
K
--
G
V
V
V
M
P
Y
Q
-------------
N
R
R
F
D
-
G
-
D
Y
L
A
M
K
---------
Q
V
V
E
Q
G
-
F
L
G
---
E
---
I
N
E
V
E
T
H
I
D
Y
Y
R
P
G
S
I
T
E
Q
G
P
K
E
N
--
G
S
F
Y
G
L
G
I
H
L
M
D
R
M
I
A
L
F
G
R
P
----
D
Q
V
T
Y
D
----
I
R
N
N
---------------------
E
V
S
E
A
V
D
N
Y
F
D
V
D
L
H
Y
------
G
S
K
L
-------------------
K
V
K
V
K
T
N
H
S
V
A
S
P
Y
P
-
R
F
I
-
V
H
G
S
N
G
S
F
I
K
Y
G
EDQ
Q
E
N
D
-
L
-
K
A
G
I
M
P
D
A
P
G
F
G
E
D
S
P
M
Y
Y
G
E
V
T
Y
R
N
G
N
G
D
W
I
K
K
Q
I
K
T
-
P
V
G
D
------------------
Y
G
R
Y
Y
D
A
V
Y
E
T
L
K
N
G
A
P
Q
------
L
V
T
K
E
Q
A
L
T
N
I
E
I
L
E
A
G
F
L
N
P
S
P
S
V
Y
H
L
K
E
-------------------------------