@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1259: (2015-12-06 )
MSDIKIMALGGVRENGKNLYVVEVNDSIFVLDAGLKYPENEQLGVDVVIPNLDYLIENKKRVQGIFLTHGHADAIGALPYIIAEVKAPVFGSPLTIELAKLFVKNSTAVKKFNNFHVIDSETEIEFQDAVISFFKTTHSIPESMGIVIGTKEGNIVYTGDFKFDQAARKYYQTDLARLAEIGRDGVLALLSDSANATSNDQVASEYEVGDEIKSVIEDAEGRVIVAAVASNLIRIQQVFDAAAENGRRVVLTGFDIENIVRTAIRMKRIHIADENMIIKPKDMTRYEDNELLILETGRMGEPINGLQKMAIGRHRYVQIKDGDLVFIVTTPSIAKEAVVARVENLIYKAGGSVKLITQNLRVSGHANGRELQLLMNLLKPKYLFPIQGEYRDLSAHAGLAQEVGMSADDIYIVKRGDIMVLEKDGFFHSGFVPAGDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVVITVSKKEKKIISKARVNTRGFVYVKKSRDILRESAELVNTTVEDYLSKDTFDWGELKGKVRDEVSKFLFDQTKRRPAILPVVMEVR
Atome Classification :
(20 SA)
.........10........20........30........40-----.--------------------..-------.....50....------------..-----..60........70........80..-----.--.-----.--...90.......--.100...--------..---------.--------.------------110-----.........120....-.-..130.......140.......150.--..-......160.......170......---.180.......190.......200-------.--.--.----.....210......-.---220---........230.......240....--------..-------.250.......260.---..-.-...270------------..--------..-------...-------..---280--...--..--....290.......300.......310.......320.......330....-..-.-340....-----..-..----350--..-.--..-..---..-360........370.......--380.....--..390.......400-.-....---...410.......420.......430.......440.......450.......460.......470.......480.......490..--.--....500.......510.......520.......530--.........540.......550.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
D
I
K
I
M
A
L
GGVRENG
K
N
L
Y
V
V
EVND
S
I
F
V
L
DAGLKYPENE-----Q--------------------L
G
-------
V
D
V
V
IPN
L
D
Y
L
------------IE-----NK
K
R
V
Q
G
I
F
L
THGHA
D
A
I
G
A
L
P
Y
I
I
A
-----
E
--V-----K--APVFGS
P
L
T
I
E
L
--
A
K
L
F
VKN--------ST---------A--------V------------K-------KFN
N
F
H
V
IDSET
E
I
E
F
-
Q
-
D
A
V
I
S
F
F
K
T
T
HSIPESM
G
I
V
I
GT--K--EG-
N
I
V
Y
TGDF
K
F
D
Q
A
A
R
K
Y
Y
Q
T
D
L
A
R
L
---
A
E
IGR
D
G
V
L
A
L
LSDSANATSND
Q
--------
V
--
A
--
S
----
E
YE
V
G
D
E
I
K
S
V
I
ED-A---E-G---
R
V
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V
A
A
V
A
S
N
L
I
R
I
Q
Q
V
F
D
A
A
AENG--------
R
R
-------
V
V
L
TGF
D
I
E
N
I
V
R
T
A
---
I
R
-
M
-
K
R
I
H
--------------IA--------DE-------
N
M
I
-------IK---P----KDM--TR--YEDN
E
L
L
I
L
ETGRMGEPI
N
G
L
Q
K
M
AIGRH
R
Y
V
Q
IKDG
D
L
V
F
I
VTT
P
S
I
A
K
E
-
A
V
-
V
-
A
-
R
V
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N
L
-----
I
Y
-KA----G----G
S
-
V
--
K
L
-
I
T
---Q
N
-
L
-
R
V
SGHAN
G
R
E
L
Q
L
L
M
N
LLK--P
K
Y
L
FPIQ--GEYR
D
L
S
A
HA
G
L
A
-
Q
-
E
-VGMS---AD
D
I
Y
I
V
KRG
D
I
M
V
L
EKDGFFHSGFVPAG
D
V
M
IDGNAIGD
V
G
N
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RDRKVLSED
G
I
F
I
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T
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SKDTF
D
W
G
E
L
K
G
K
V
R
D
E
----
V
S
K
F
L
F
D
Q
TKRRP
A
I
L
P
V
V
M
EVR
1
PsiBlast_PDB
99.25
39%
-104
- C1 -
3ZQ4
4
RNJ1_BACSU
A:
[11-555]
-----
V
F
A
L
G
G
L
G
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K
N
T
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Q
F
Q
D
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F
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---
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---
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Y
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-------
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-----
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----
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----
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---
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M
H
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K
L
A
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D
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C
G
I
P
---
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N
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D
N
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L
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P
I
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M
E
V
-
21
PsiBlast_CBE
97.96
39%
-106
- C1 -
3ZQ4
4
RNJ1_BACSU
E:
[11-555]
-----
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
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V
L
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K
F
P
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-----
L
--------------------
L
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-------
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Y
T
Y
L
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K
-----
N
E
D
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G
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R
-----
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-----
N
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Y
G
G
K
L
A
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G
L
--
L
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---------
L
--------
L
------------
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T
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M
---
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-----
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---
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L
R
L
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K
F
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P
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--
G
E
Y
R
M
Q
K
M
H
V
K
L
A
-
T
-
D
-
C
G
I
P
---
E
E
N
C
F
I
M
D
N
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A
L
K
G
D
E
A
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----------
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L
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N
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V
-
22
PsiBlast_CBE
97.86
39%
-106
- C1 -
3ZQ4
4
RNJ1_BACSU
D:
[11-555]
-----
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
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L
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F
P
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Q
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M
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A
-
T
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C
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----------
D
L
I
N
D
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L
I
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N
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L
Q
K
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S
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I
K
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T
D
T
----
L
A
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F
L
Y
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K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
-
23
PsiBlast_CBE
96.93
39%
-105
- C1 -
3ZQ4
4
RNJ1_BACSU
C:
[11-555]
-----
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
D
E
-----
L
--------------------
L
G
-------
I
D
Y
V
I
P
D
Y
T
Y
L
------------
V
K
-----
N
E
D
K
I
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
R
-----
Q
--
V
-----
N
--
I
P
V
Y
G
G
K
L
A
I
G
L
--
L
R
N
K
L
E
E
--------
H
G
---------
L
--------
L
------------
R
-------
Q
-
T
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
-
N
I
V
H
T
G
D
F
K
F
D
F
T
P
V
G
E
-
P
A
N
L
T
K
M
---
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
E
F
--------
T
--
M
--
S
----
E
R
R
V
G
E
S
I
H
D
I
F
R
K
-
V
---
D
-
G
---
R
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
K
-------
V
A
V
F
G
R
S
M
E
S
A
I
E
I
G
---
Q
T
-
L
-
G
Y
I
N
---------------
C
--------
P
K
-------
N
T
F
-------
I
E
---
H
----
N
E
I
--
N
R
--
M
P
A
N
K
V
T
I
L
C
T
G
S
Q
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
S
S
P
I
P
G
N
T
-
I
S
-
V
-
S
-
R
T
I
N
Q
-----
L
Y
-
R
A
----
G
----
A
E
-
V
--
I
H
-
G
P
---
L
N
D
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
H
--
G
E
Y
R
M
Q
K
M
H
V
K
L
A
-
T
-
D
-
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
------------
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
----
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
-
78
HHSearch
89.82
34%
-98
* C1 *
3BK2
7
RNJ_THET2
A:
[14-561]
Q
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
-----
M
--------------------
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
-----
M
--
I
FGKES
P
--
V
P
I
Y
G
A
R
L
T
L
G
L
--
L
R
G
K
L
E
E
--------
F
G
---------
L
--------
R
------------
P
G------
A
F
-
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
-
T
I
V
H
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
--
S
----
E
M
E
I
A
K
E
L
D
R
V
I
G
R
-
A
---
P
-
G
---
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
R
I
A
---
L
E
-
L
-
G
Y
L
K
--------------
V
---------
K
--------
D
R
L
-------
Y
T
---
L
----
E
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
-
N
-
R
V
I
N
R
-----
L
Y
-
A
L
----
G
----
A
Y
-
V
--
L
Y
-
P
P
T--
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
--
G
E
V
R
H
Q
M
N
F
K
W
L
A
-
E
-
S
-
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
-----
V
V
E
V
V
S
R
G
F
V
K
A
G
----
E
--
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
-
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
----
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
-
5
PsiBlast_PDB
87.10
34%
-93
- C1 -
3BK2
7
RNJ_THET2
A:
[17-561]
---
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
-----
M
--------------------
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FGK
E
--
S
-----
P
--
V
P
I
Y
G
A
R
L
T
L
G
L
--
L
R
G
K
L
E
E
--------
F
G
---------
L
--------
R
------------
P
-------
G
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
-
T
I
V
H
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
--
S
----
E
M
E
I
A
K
E
L
D
R
V
I
G
R
-
A
---
P
-
G
---
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
R
I
A
---
L
E
-
L
-
G
Y
L
K
--------------
V
K
--------
D
R
-------
L
Y
T
-------
L
---------
E
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
-
N
-
R
V
I
N
R
-----
L
Y
-
A
L
----
G
----
A
Y
-
V
--
L
Y
P
P
T
---
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
--
G
E
V
R
H
Q
M
N
F
K
W
L
A
-
E
-
S
-
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
--
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
---
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
--
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
---
K
K
P
L
E
------
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
-
4
PsiBlast_PDB
86.98
34%
-91
- C1 -
3BK1
7
RNJ_THET2
A:
[17-561]
---
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
-----
M
--------------------
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FGK
E
--
S
-----
P
--
V
P
I
Y
G
A
R
L
T
L
G
L
--
L
R
G
K
L
E
E
--------
F
G
---------
L
--------
R
------------
P
-------
G
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
-
T
I
V
H
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
--
S
----
E
M
E
I
A
K
E
L
D
R
V
I
G
R
-
A
---
P
-
G
---
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
R
I
A
---
L
E
-
L
-
G
Y
L
K
--------------
V
K
--------
D
R
-------
L
Y
T
-------
L
---------
E
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
-
N
-
R
V
I
N
R
-----
L
Y
-
A
L
----
G
----
A
Y
-
V
--
L
Y
P
P
T
---
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
--
G
E
V
R
H
Q
M
N
F
K
W
L
A
-
E
-
S
-
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
--
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
---
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
--
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
---
K
K
P
L
E
------
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
-
2
PsiBlast_PDB
86.82
34%
-97
- C1 -
3T3N
2
RNJ_THET2
A:
[18-562]
---
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
-----
M
--------------------
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FGK
E
--
S
-----
P
--
V
P
I
Y
G
A
R
L
T
L
G
L
--
L
R
G
K
L
E
E
--------
F
G
---------
L
--------
R
------------
P
-------
G
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
-
T
I
V
H
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
--
S
----
E
M
E
I
A
K
E
L
D
R
V
I
G
R
-
A
---
P
-
G
---
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
R
I
A
---
L
E
-
L
-
G
Y
L
K
--------------
V
K
--------
D
R
-------
L
Y
T
-------
L
---------
E
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
-
N
-
R
V
I
N
R
-----
L
Y
-
A
L
----
G
----
A
Y
-
V
--
L
Y
P
P
T
---
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
--
G
E
V
R
H
Q
M
N
F
K
W
L
A
-
E
-
S
-
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
--
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
---
V
V
S
R
G
F
V
K
A
G
E
R
--
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
---
K
K
P
L
E
------
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
--
3
PsiBlast_PDB
86.77
34%
-96
- C1 -
3T3O
3
RNJ_THET2
A:
[18-562]
---
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
-----
M
--------------------
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FGK
E
--
S
-----
P
--
V
P
I
Y
G
A
R
L
T
L
G
L
--
L
R
G
K
L
E
E
--------
F
G
---------
L
--------
R
------------
P
-------
G
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
-
T
I
V
H
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
--
S
----
E
M
E
I
A
K
E
L
D
R
V
I
G
R
-
A
---
P
-
G
---
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
R
I
A
---
L
E
-
L
-
G
Y
L
K
--------------
V
K
--------
D
R
-------
L
Y
T
-------
L
---------
E
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
-
N
-
R
V
I
N
R
-----
L
Y
-
A
L
----
G
----
A
Y
-
V
--
L
Y
P
P
T
---
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
--
G
E
V
R
H
Q
M
N
F
K
W
L
A
-
E
-
S
-
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
--
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
---
V
V
S
R
G
F
V
K
A
G
E
R
--
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
---
K
K
P
L
E
------
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
--
25
PsiBlast_CBE
81.99
32%
-100
- C1 -
5A0T
4
?
B:
[19-452]
---
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
-----
Q
--------------------
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
R
-----
E
K-
P
-----
D
--
I
P
L
I
G
S
K
L
T
L
A
L
IE
A
K
L
---
Q
--------
E
H
---------
R
--------
I
------------
R
-------
P
Y
T
-
L
E
V
A
E
G
H
R
E
-
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
-
M
V
V
H
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
--
P
----
E
R
D
I
S
N
V
L
R
Q
V
F
A
N
-
A
---
R
-
K
---
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
G
I
A
---
R
D
-
L
-
G
Y
L
K
--------------
V
P
---------
P
-------
G
L
V
-------
V
D
---
V
----
K
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
Q
G
E
P
M
A
A
L
S
R
M
A
-
N
R
D
H
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
-
Y
-
R
V
I
N
G
-----
L
T
-
R
W
----
G
----
A
N
V
V
--
H
K
-
G
N
---
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
--
G
E
W
R
H
L
R
A
N
A
E
L
G
-
A
-
L
-
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
-------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.84
32%
-99
- C1 -
5A0V
3
?
A:
[19-455]
---
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
-----
Q
--------------------
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
R
-----
E
K-
P
-----
D
--
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
---
Q
--------
E
H
---------
R
--------
I
------------
R
-------
P
Y
T
-
L
E
V
A
E
G
H
R
E
-
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
-
M
V
V
H
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
--
P
----
E
R
D
I
S
N
V
L
R
Q
V
F
A
N
-
A
---
R
-
K
---
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
G
I
A
---
R
D
-
L
-
G
Y
L
K
--------------
V
P
---------
P
-------
G
L
V
-------
V
D
---
V
----
K
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
Q
G
E
P
M
A
A
L
S
R
M
A
-
N
R
D
H
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
-
Y
-
R
V
I
N
G
-----
L
T
-
R
W
----
G
----
A
N
V
V
--
H
K
-
G
N
---
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
--
G
E
W
R
H
L
R
A
N
A
E
L
G
-
A
-
L
-
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.50
32%
-101
- C1 -
5A0T
4
?
A:
[19-455]
---
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
-----
Q
--------------------
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
R
-----
E
K-
P
-----
D
--
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
---
Q
--------
E
H
---------
R
--------
I
------------
R
-------
P
Y
T
-
L
E
V
A
E
G
H
R
E
-
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
-
M
V
V
H
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
--
P
----
E
R
D
I
S
N
V
L
R
Q
V
F
A
N
-
A
---
R
-
K
---
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
G
I
A
---
R
D
-
L
-
G
Y
L
K
--------------
V
P
---------
P
-------
G
L
V
-------
V
D
---
V
----
K
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
Q
G
E
P
M
A
A
L
S
R
M
A
-
N
R
D
H
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
-
Y
-
R
V
I
N
G
-----
L
T
-
R
W
----
G
----
A
N
V
V
--
H
K
-
G
N
---
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
--
G
E
W
R
H
L
R
A
N
A
E
L
G
-
A
-
L
-
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
----------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.31
32%
-99
- C1 -
5A0V
4
?
B:
[19-452]
---
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
-----
Q
--------------------
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
R
-----
E
K-
P
-----
D
--
I
P
L
I
G
S
K
L
T
L
A
L
IE
A
K
L
---
Q
--------
E
H
---------
R
--------
I
------------
R
-------
P
Y
T
-
L
E
V
A
E
G
H
R
E
-
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
-
M
V
V
H
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
--
P
----
E
R
D
I
S
N
V
L
R
Q
V
F
A
N
-
A
---
R
-
K
---
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
G
I
A
---
R
D
-
L
-
G
Y
L
K
--------------
V
P
---------
P
-------
G
L
V
-------
V
D
---
V
----
K
T
L
--
D
D
--
L
P
D
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V
V
L
V
C
T
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G
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M
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A
L
S
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M
A
-
N
R
D
H
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I
R
I
V
N
G
D
T
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L
A
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S
L
I
P
G
N
E
-
N
A
-
V
-
Y
-
R
V
I
N
G
-----
L
T
-
R
W
----
G
----
A
N
V
V
--
H
K
-
G
N
---
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
--
G
E
W
R
H
L
R
A
N
A
E
L
G
-
A
-
L
-
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
-------------------------------------------------------------------------------------------------------------------------
82
HHSearch
60.55
17%
-76
- C1 -
2I7T
3
CPSF3_HUMAN
A:
[10-458]
-
D
Q
L
L
I
R
P
L
G
A
G
Q
E
V
G
R
S
C
I
I
L
E
F
K
G
R
K
I
M
L
D
C
G
I
H
P
G
L
E
----------------------------
G
-------
M
D
-
A
L
P
Y
I
D
L
--------------
I
-----
D
P
A
E
I
D
L
L
L
I
S
H
F
H
L
D
H
C
G
A
L
P
W
F
L
Q
-----
K
--
T
-----
S
FK
G
R
T
F
M
T
H
A
T
K
A
I
--
Y
R
W
L
L
S
D
--------
Y
V
---------
K
---------LYT
E
T
D
L
E
----
E
-------
S
M
D
K
I
E
T
I
N
F
H
E
V
K
E
V
-
A
-
G
I
K
F
W
C
Y
H
A
G
H
-
V
L
G
A
A
M
F
M
I
E
I
--
A
--
G
V
-
K
L
L
Y
T
G
D
F
S
R
Q
---------
M
---
A
---
A
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Y
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T
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--------
K
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E
E
--
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----
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A
R
F
C
N
T
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H
D
I
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N
R
-----
G
-
G
---
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L
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F
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--
L
G
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A
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E
L
L
L
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L
D
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Y
W
Q
N
H
PELHD
I
P
-------
I
Y
Y
A
----------------------------------------------------------
F
-------
K
H
I
S
N
L
----
K
S
M
DH
F
D
--
D
I
G
P
S
V
V
M
A
S
P
G
M
M
Q
S
G
L
S
---
R
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---
L
F
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S
W
C
T
D
K
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N
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A
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Y
C
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-
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-----
I
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----
G
----
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-
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---
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-
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-
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A
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Y
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Q
T
S
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F
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R
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K
--
P
P
H
V
I
L
V
H
--
G
E
Q
N
E
M
A
R
L
K
A
A
L
-
I
R
E
-
Y
E
D
N
DE
V
H
I
E
V
H
N
P
R
N
T
E
A
V
T
L
N
F
R
-----------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
60.44
21%
-73
- C1 -
3AF5
13
?
A:
[187-650]
-
R
W
I
R
I
T
G
L
G
G
F
R
E
V
G
R
S
A
L
L
V
Q
T
D
E
S
F
V
L
V
D
F
G
V
N
V
A
M
L
N
D
P
Y
K
A
F
--------------------
P
H
-------
F
D
--
A
P
E
F
Q
Y
V
-------------
L
-----
R
E
G
L
L
D
A
I
I
I
T
H
A
H
L
D
H
C
G
M
L
P
Y
L
F
R
-----
Y
NL
F
-----
D
--
G
P
I
Y
T
T
P
P
T
R
D
L
--
M
V
L
L
Q
K
D
--------
F
I
---------
E
I
Q
Q
S
N
GQ-
D
PL----------
Y
R
P
R
D
I
K
E
V
I
K
H
T
I
T
L
D
Y
G
E
V
R
D
I
-
S
P
D
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
I
V
H
L
H
I
--
G
NG
L
H
-
N
I
A
I
T
G
D
F
K
F
I
P
T
R
L
L
E
P
------
A
---
N
A
K
F
-
P
R
L
E
T
L
V
M
E
S
T
Y
G
G
A
N
D
I
--------
Q
--
M
--
P
----
R
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A
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R
L
I
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N
-
T
I
K
R
G
-
G
---
K
V
L
I
P
A
M
A
--
V
G
R
A
Q
E
V
M
M
V
L
E
E
Y
A
--------
R
I
GGIE
V
P
-
I
Y
L
D
G
M
I
W
E
A
-
T
A
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H
---
T
A
-
Y
P
E
Y
L
S
R
R
L
R
E
Q
I
FKEGYNP
F
---------
L
S
-------
E
I
F
-------
H
P
VAN
S
R
E
R
-
Q
D
I
--
I
D
--
S
N
E
P
A
I
I
I
A
S
S
G
M
L
V
G
------
G
P
S
V
E
Y
F
K
Q
L
A
P
D
P
K
N
S
I
I
F
V
S
Y
Q
A
E
G
T
L
-
G
R
Q
V
-
Q
-
S
G
I
R
E
-----
I
P
-
M
V
----
G
EEG
R
T
E
-
V
--
I
K
-
V
N
M
E
V
H
T
I
D
-
G
F
S
G
H
A
D
R
R
E
L
M
N
Y
V
A
K
V
R
PR
P
E
R
I
I
T
V
H
--
G
E
P
Q
K
C
L
D
L
A
T
S
I
H
R
-
K
-
F
G
I
S
------
T
R
A
P
N
N
L
D
T
I
R
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
56.24
16%
-75
- C1 -
2AZ4
2
?
A:
[5-428]
-
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
E
L
-----
D
L-------------------
P
D
DH
I
E
T
L
I
N
N
R
L
V
P
E
L
K
D
L
YDPRLG
Y
E
Y
H
G
A
E
D
-----
K
D
Y
Q
H
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
D
P
-----
A
-----------
V
P
L
Y
T
L
K
E
T
K
M
I
--
L
N
S
L
N
R
K
--------
G
D
---------
F
LIPSPFEE
K
N-----------
F
-------
T
R
-
E
M
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
I
S
V
E
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V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
-
F
I
T
Y
T
G
D
L
R
L
H
G
H
N
R
----
E
E
T
L
A
F
---
C
E
K
A
-
K
H
T
E
L
L
M
M
E
G
V
S
I
S
F
P
E
R
EPDPAQIA
V
--
V
--
S
----
E
E
D
L
V
Q
H
L
V
R
L
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L
E
-
N
---
P
N
R
---
Q
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
---
E
K
S
P
--------
R
T
-------
V
V
L
E
A
N
M
A
A
L
L
L
E
V
F
G
I
E
V
R
-
Y
-
Y
Y
A
E
-------------------------
S
-------
G
K
I
-------
P
E
---
L
----
N
P
A
--
L
E
--
I
P
Y
D
T
L
L
---
K
D
K
T
D
Y
L
----
W
Q
V
V
N
---
Q
F
D
N
L
Q
E
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S
L
Y
I
H
S
D
A
Q
P
L
G
D
F
-
D
P
Q
Y
-
R
-
V
F
L
D
L
-----
L
A
-
K
K
----
D
----
I
T
-
F
--
V
R
---------
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
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--
P
Q
V
L
V
P
I
H
--
T
L
K
P
E
K
L
E
N
P
Y
----------
G
----
E
R
I
-
L
P
E
R
G
E
Q
I
V
L
--------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
55.93
17%
-77
- C1 -
3IEK
22
RNSE_THET8
A:
[1-431]
---
M
R
I
V
P
F
G
A
A
R
E
V
T
G
S
A
H
L
L
L
A
G
G
R
R
V
L
L
D
C
G
M
F
Q
G
K
E
E
-----
A
--------------------
R
-----------
N
H
A
P
F
---------------
G
F
-----
D
P
K
E
V
D
A
V
L
L
T
H
A
H
L
D
H
V
G
R
L
P
K
L
F
R
-----
E
--
G
Y----
R
--
G
P
V
Y
A
T
R
A
T
V
L
L
--
M
E
I
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L
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D
--------
A
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---------
K
--------
V
MDEPFFG
P
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-------
A
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L
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L
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G
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-
A
L
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L
A
F
G
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A
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-
L
P
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A
F
V
V
A
Q
G
--
E
--
G
R
-
T
L
V
Y
S
G
D
L
G
N
R
E
K
D
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L
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---
D
-------
P
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L
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L
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L
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--------
P
--
Y
R
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T
----
V
R
E
F
L
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L
E
K
T
L
S
Q
-----
G
-
G
---
K
V
L
I
P
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F
A
--
V
E
R
A
Q
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I
L
Y
V
L
Y
T
H
G
HRL
P
R
---
A
P
-------
I
Y
L
D
S
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M
A
G
R
V
L
S
L
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---
P
R
-
L
V
R
Y
F
S
--------------
E
E
V
Q
A
H
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L
Q
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G
K
NPFRPAG
L
E
V
-------
V
E
---
H
T
E
A
S
K
A
L
--
N
R
--
A
P
G
P
M
V
V
L
A
G
S
G
M
L
-
A
G
G
R
I
L
H
-----
H
L
K
H
G
L
S
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N
A
L
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---
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G
G
F
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G
H
A
G
Q
D
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L
L
D
W
L
Q
--
G
--
E
P
R
V
V
L
V
H
--
G
E
E
E
K
L
L
A
L
G
K
L
L
-
A
-
L
-
R
G
Q
E
------
V
S
L
A
R
F
G
E
G
V
P
V
--------------------------------------------------------------------------------------------------------------------------------------------
100
Fugue
55.35
15%
-75
- C1 -
2AZ4
2
?
A:
[5-429]
-
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
E
L
-----
D
LPDDH
I
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L
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N
RLVPELKD
L
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-------
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L
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-----
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A
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H
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M
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Y
L
D
P
-----
A
--
V
---------
P
L
Y
T
L
K
E
T
K
M
I
--
L
N
S
L
N
R
K
GDFLIPSP
F
E
---------
E
--------
K
------------
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-------
F
T
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L
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K
N
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K
S
---
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R
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L
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L
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N
Q
F
D
N
L
Q
----------
E
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L
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A
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P
L
G
D
F
D
P
Q
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Y
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R
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V
F
L
D
L
-----
L
A
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K
K
----
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----
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T
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F
--
V
R
-
L
---------
A
C
S
G
H
A
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A
L
I
E
--
P
Q
V
L
V
P
I
H
--
T
L
K
P
E
K
L
E
N
------------
P
---
Y
G
E
R
I
L
P
E
R
G
E
Q
I
V
L
--------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
54.55
18%
-63
- C1 -
2YCB
7
?
A:
[178-636]
-
D
W
A
R
L
T
A
M
G
G
F
R
E
V
G
R
S
C
L
Y
L
Q
T
P
N
S
R
V
L
L
D
C
G
V
N
V
A
G
G
D
-----
D
------------------------------
K
N
S
Y
P
Y
L
N
V
P
------------
E
F
-----
T
L
D
S
L
D
A
V
I
I
T
H
A
H
L
D
H
S
G
F
L
P
Y
L
Y
H
-----
Y
--
G
Y----
D
--
G
P
V
Y
C
T
A
P
T
R
D
L
--
M
T
L
L
Q
L
D
--------
H
I
D
I
A
H
R
E
DEP
L
--------
P
------------
F
N
V
K
H
V
K
K
S
V
K
H
T
I
T
L
D
Y
G
E
V
T
D
I
A
P
-
D
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
M
A
H
L
H
I
GD
G
--
Q
H
-
N
M
V
Y
T
G
D
F
K
Y
E
Q
S
R
L
L
E
------
A
A
---
A
N
R
-
F
P
R
I
E
T
L
V
M
E
S
T
Y
G
G
H
E
D
V
--------
Q
--
P
--
S
R
N
R
A
E
K
E
L
V
K
T
I
Y
S
T
L
R
R
-----
G
-
G
---
K
I
L
I
P
V
F
A
--
V
G
R
A
Q
E
L
M
I
V
L
E
E
Y
I
--------
R
T
GIIDE
V
P
V
Y
I
D
G
M
I
W
E
A
-
N
A
I
H
---
T
A
R
P
-
E
Y
L
S
--------------
K
D
L
R
D
Q
I
FHM
G
H
-------
N
P
F
ISDI
F
H
K
V
N
G
--
M
----
D
E
R
--
R
E
I
V
E
G
E
P
S
I
I
L
S
T
S
G
M
L
T
-
G
G
N
S
L
-----
E
Y
F
K
W
L
C
E
D
P
D
N
S
L
V
F
V
G
Y
Q
A
E
G
S
L
-
G
R
-
R
I
Q
-
K
G
W
K
E
-----
I
P
-
L
K
D
EDD
K
M
R
V
-
Y
N
-
V
--
R
M
-
N
I
---
K
T
-
I
E
G
F
S
G
H
S
D
R
R
Q
L
M
E
Y
V
K
R
I
S
PK
P
E
K
I
L
L
C
H
--
G
D
N
Y
K
T
L
D
L
A
S
S
I
-
Y
-
R
T
Y
R
------
I
E
T
K
T
P
L
N
L
E
T
V
R
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
51.69
18%
-82
- C1 -
5AHR
2
A:
[1-343]
---------------------------------------
S
M
-----
T
--------------------
C
P
-------
F
Y
K
K
I
P
G
T
G
F
T
------------
V
D
AFQYG
V
V
E
G
C
T
A
Y
F
L
T
H
F
H
S
D
H
Y
A
G
L
S
---
K
-----
H
--
F
-----
T
--
F
P
V
Y
C
S
----
E
I
--
T
G
N
L
L
K
N
--------
K
L
---------
H
--------
V
------------
Q
-------
E
Q
Y
-
I
H
P
L
P
L
D
T
E
C
I
V
-
N
-
G
V
K
V
V
L
L
D
A
N
H
C
-
P
G
A
V
M
I
L
F
Y
L
--
P
--
N
G
T
V
I
L
H
T
G
D
F
R
A
D
P
S
M
E
R
------------
S
L
L
A
D
Q
K
V
H
M
L
Y
L
D
T
T
Y
C
S
P
E
Y
T
--------
F
--
P
--
S
----
Q
Q
E
V
I
R
F
A
I
N
T
A
F
E
-
A
---
V
-
T
L
NP
H
A
L
V
V
C
G
T
Y
S
I
G
K
E
K
V
F
L
A
I
A
D
V
L
G
--------
S
K
-------
V
G
M
S
-------
Q
E
K
Y
---
K
T
-
L
-
Q
C
L
N
--------------
I
P
--------
E
I
-------
N
S
L
-------
I
T
---
T
----
D
---------------
M
C
S
S
L
V
H
L
L
P
M
M
Q
I
N
F
K
G
L
Q
S
H
L
K
K
C
G
G
K
Y
N
Q
I
L
A
F
R
P
T
V
I
P
Q
T
-
K
G
-
N
-
I
-
S
I
Y
G
I
-----
P
Y
---------------------------------
S
E
H
S
S
Y
L
E
M
K
R
F
V
Q
W
L
K
--
P
Q
K
I
I
P
T
V
NV
G
T
W
K
S
R
S
T
M
E
K
Y
F
-
R
-
E
-
W
K
L
E
---
A
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------