@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1262: (2015-12-06 )
MKNKGLIATLILLTILVVGELFYNKSEKHLNLSEKQVVKIGILQYVPHDALDAIEKGVEDGLAQEGYKGKKVKLTVLNAEADQSKIQAMSKQLVNHHNDILIGIATPSAQGLAASTKDTPIIMGAVSDPLGAKLVTNMKKPTTNVTGLSNVVPTKQTVQLIKDITPNVKRIGILYASSEDNSVSQVTEFTKYAQKAGLEVLKYSVPSTNEIKTSMSVMTKKVDAVFVPQDNTIASAFRTVIVAANQANIPVYSSVDTMVEQGSIASVAQSQYGLGLETAKQAIKVLRGKPVKDVPVKVIDTGKPSLNLKAAKHLGIKIPKKIMKQAEITVKVDD
Atome Classification :
(20 SA)
...-......10........20........30........40....-.---...50......-..60.......-.70.......-.80........90....--....--100.....----.------.-110....--...120.......130.......140.....-..150.......160....-.-.-----.170...-..-.-.-180........190.-...--...-----200..-.---.---....210....-..---.--220-----.....-....230...-.....240.....--...250....-..-----.-----260-.---.-.-......270.......280.......290..-.....300.......310.......320.......330..---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKN-K
G
L
I
A
T
L
I
L
L
T
I
L
V
V
G
E
L
FYNKSEKHLNL
S
E
K
Q
V
V
K
I
G
I
L
QY-V---P
H
D
A
L
D
A
I
E
K
G
-
V
E
D
G
L
A
QEGYK-G
K
K
V
K
L
T
V
L
N-AEA
D
Q
S
K
I
Q
A
M
S
K
Q
L
V
N
--HHN
D
--
I
L
I
G
IATP----S------A-QGLAAST--KDT
P
I
I
M
G
AVSDPL
G
A
K
L
V
T
NMKKPTTNVTG-LSNVVP
T
K
Q
T
V
Q
L
I
K
D
ITP-N-
V
-----
K
R
I
G
I
L
Y
-AS-S-E-D-N
S
V
S
Q
V
T
E
F
T
K
Y
A
-
Q
K
A--G
L
E
-----
V
-
L
K
Y-S---V---PS
T
N
E
I
K
T
S
M
S
-
V
M
---T--K-------KV
D
A
V
-
F
VPQD-
N
T
I
A
-
S
A
F
R
T
V
-
I
V
AANQ--ANI
P
V
Y
S
S
V
D
-
T
M
-----
V
-----E---Q---G-
S
-
I
A
S
V
A
Q
S
Q
YGL
G
L
E
T
A
K
Q
A
I
K
V
LRGKPVKDV-
P
V
K
V
I
DTGKPSL
N
L
K
A
A
K
HLGIK
I
P
K
K
I
MKQA
E
I
T
V
K
VDD---
21
HHSearch
98.50
54%
-78
- C1 -
3LFT
1
?
A:
[2-295]
-------------------------------------
N
A
K
I
G
V
L
Q
F
-
V
---
S
H
P
S
L
D
L
I
Y
K
G
-
I
Q
D
G
L
A
E
E
G
Y
K
-
D
D
Q
V
K
I
D
F
M
N
-
S
E
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
--
N
G
N
D
--
L
V
V
G
I
A
T
P
----
A
------
A
-
Q
G
L
A
S
A
T
--
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
-
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
P
-
N
-
V
-----
K
T
I
G
A
L
Y
-
S
S
-
S
-
E
-
D
-
N
S
K
T
Q
V
E
E
F
K
A
Y
A
-
E
K
A
--
G
L
T
-----
V
-
E
T
F
-
A
---
V
---
P
S
T
N
E
I
A
S
T
V
T
-
V
M
---
T
--
S
-------
K
V
D
A
I
-
W
V
P
I
D
-
N
T
I
A
-
S
G
F
P
T
V
-
V
S
S
N
Q
S
--
S
K
K
P
I
Y
P
S
A
T
-
A
M
-----
V
-----
E
---
V
---
G
-
G
-
L
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
K
P
A
D
T
-
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
L
G
I
T
I
P
E
S
V
L
K
E
A
G
Q
V
I
-------
1
PsiBlast_PDB
97.54
53%
-79
- C1 -
3LFT
1
?
A:
[4-291]
---------------------------------------
K
I
G
V
L
Q
F
-
V
---
S
H
P
S
L
D
L
I
Y
K
G
-
I
Q
D
G
L
A
E
E
G
Y
K
-
D
D
Q
V
K
I
D
F
M
N
-
S
E
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
--
N
G
N
D
--
L
V
V
G
I
A
T
P
----
A
------
A
-
Q
G
L
A
S
A
T
--
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
-
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
P
-
N
-
V
-----
K
T
I
G
A
L
Y
-
S
S
-
S
-
E
-
D
-
N
S
K
T
Q
V
E
E
F
K
A
Y
A
-
E
K
A
--
G
L
T
-----
V
-
E
T
F
-
A
---
V
---
P
S
T
N
E
I
A
S
T
V
T
-
V
M
---
T
--
S
-------
K
V
D
A
I
-
W
V
P
I
D
-
N
T
I
A
-
S
G
F
P
T
V
-
V
S
S
N
Q
S
--
S
K
K
P
I
Y
P
S
A
T
-
A
M
-----
V
-----
E
---
V
---
G
-
G
-
L
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
K
P
A
D
T
-
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
L
G
I
T
I
P
E
S
V
L
K
E
A
G
Q
V
I
-------
22
HHSearch
90.92
38%
-79
- C1 -
3LKV
6
?
A:
[7-301]
------------------------------------
K
T
A
K
V
A
V
S
Q
I
-
V
---
E
H
P
A
L
D
A
T
R
Q
G
-
L
L
D
G
L
K
A
K
G
Y
E
E
G
K
N
L
E
F
D
Y
K
T
-
A
Q
G
N
P
A
I
A
V
Q
I
A
R
Q
F
V
G
--
E
N
P
D
--
V
L
V
G
I
A
T
P
----
T
------
A
-
Q
A
L
V
S
A
T
--
K
T
I
P
I
V
F
T
A
V
T
D
P
V
G
A
K
L
V
K
Q
L
E
Q
P
G
K
N
V
T
G
-
L
S
D
L
S
P
V
E
Q
H
V
E
L
I
K
E
I
L
P
-
N
-
V
-----
K
S
I
G
V
V
Y
-
N
P
-
G
-
E
-
A
-
N
A
V
S
L
M
E
L
L
K
L
S
A
-
A
K
H
--
G
I
K
-----
L
-
V
E
A
-
T
---
A
---
L
K
S
A
D
V
Q
S
A
T
Q
-
A
I
---
A
--
E
-------
K
S
D
V
I
-
Y
A
L
I
D
-
N
T
V
A
-
S
A
I
E
G
M
-
I
V
A
A
N
Q
--
A
K
T
P
V
F
G
A
A
T
-
S
Y
-----
V
-----
E
---
R
---
G
-
A
-
I
A
S
L
G
F
D
Y
Y
Q
I
G
V
Q
T
A
D
Y
V
A
A
I
L
E
G
K
E
P
G
S
L
-
D
V
Q
V
A
K
G
S
D
L
V
I
N
K
T
A
A
E
Q
L
G
I
T
I
P
E
A
V
L
A
R
A
T
S
T
K
-------
2
PsiBlast_PDB
90.13
38%
-78
- C1 -
3LKV
6
?
A:
[10-301]
---------------------------------------
K
V
A
V
S
Q
I
-
V
---
E
H
P
A
L
D
A
T
R
Q
G
-
L
L
D
G
L
K
A
K
G
Y
E
E
G
K
N
L
E
F
D
Y
K
T
-
A
Q
G
N
P
A
I
A
V
Q
I
A
R
Q
F
V
G
--
E
N
P
D
--
V
L
V
G
I
A
T
P
----
T
------
A
-
Q
A
L
V
S
A
T
--
K
T
I
P
I
V
F
T
A
V
T
D
P
V
G
A
K
L
V
K
Q
L
E
Q
P
G
K
N
V
T
G
-
L
S
D
L
S
P
V
E
Q
H
V
E
L
I
K
E
I
L
P
-
N
-
V
-----
K
S
I
G
V
V
Y
-
N
P
-
G
-
E
-
A
-
N
A
V
S
L
M
E
L
L
K
L
S
A
-
A
K
H
--
G
I
K
-----
L
-
V
E
A
-
T
---
A
---
L
K
S
A
D
V
Q
S
A
T
Q
-
A
I
---
A
--
E
-------
K
S
D
V
I
-
Y
A
L
I
D
-
N
T
V
A
-
S
A
I
E
G
M
-
I
V
A
A
N
Q
--
A
K
T
P
V
F
G
A
A
T
-
S
Y
-----
V
-----
E
---
R
---
G
-
A
-
I
A
S
L
G
F
D
Y
Y
Q
I
G
V
Q
T
A
D
Y
V
A
A
I
L
E
G
K
E
P
G
S
L
-
D
V
Q
V
A
K
G
S
D
L
V
I
N
K
T
A
A
E
Q
L
G
I
T
I
P
E
A
V
L
A
R
A
T
S
T
K
-------
39
HHSearch
60.51
20%
-59
- C1 -
2DRI
1
RBSB_ECOLI
A:
[2-257]
--------------------------------------
D
T
I
A
L
V
V
S
-
T
L--
N
N
P
F
F
V
S
L
K
D
G
-
A
Q
K
E
A
D
K
L
G
Y
N
------
L
V
V
L
D
-
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
--
R
G
T
K
--
I
L
L
I
N
P
T
D
SD--
A
V
G
N
A
--
V
-
K
M
A
N
Q
----
A
N
I
P
V
I
T
L
D
R
Q
A
T
K
G
---------
E
V
V
S
H
I
A
-
S
D
N
V
L
G
G
K
I
A
G
D
Y
I
A
K
K
A
G
E
G
-
A
-----
K
V
I
E
L
Q
G
-
I
A
-
G
-
T
-
S
-
A
A
R
E
R
G
E
G
F
Q
Q
A
V
-
A
A
H
--
K
F
N
-----
V
-
L
A
S
-
Q
---
P
AD-
F
D
R
I
K
G
L
N
V
M
Q
-
N
L
L
T
A
H
--
P
-------
D
V
Q
A
V
-
F
A
Q
N
D
-
E
M
A
L
-
G
A
L
R
A
L
-
Q
T
A
G
K
---
S
D
V
M
V
V
G
F
D
G
-
T
P
-----
D
G
E
K
A
V
N
---
D
---
G
K
L
-
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
E
K
V
Q
A
K
-
Y
P
V
D
L
K
L
V
V
K
Q
--------------------------------
28
HHSearch
57.73
19%
-46
* C1 *
2IOY
1
?
A:
[2-275]
--------------------------------------
K
T
I
G
L
V
I
S
-
T
L--
N
N
P
F
F
V
T
L
K
N
G
-
A
E
E
K
A
K
E
L
G
Y
K
------
I
I
V
E
D
-
S
Q
N
D
S
S
K
E
L
S
N
V
E
D
L
I
Q
--
Q
K
V
D
--
V
L
L
I
N
P
V
D
SD--
A
V
V
T
A
--
I
-
K
E
A
N
S
----
K
N
I
P
V
I
T
I
D
R
S
A
N
G
G
---------
D
V
V
C
H
I
A
-
S
D
N
V
K
G
G
E
M
A
A
E
F
I
A
K
A
L
K
-
G
-
K
-----
G
N
V
V
E
L
E
-
G
I
P
G
-
A
-
S
-
A
A
R
D
R
G
K
G
F
D
E
A
I
-
A
K
Y
P-
D
I
K
-----
I
-
V
A
K
-
Q
---
A
AD-
F
D
R
S
K
G
L
S
V
M
E
-
N
I
L
Q
A
Q
--
P
-------
K
I
D
A
V
-
F
A
Q
N
D
-
E
M
A
L
-
G
A
I
K
A
I
-
E
A
A
N
R
---
Q
G
I
I
V
V
G
F
D
G
-
T
E
D
A
L
K
A
I
-----
K
---
E
---
G
K
M
-
A
A
T
I
A
Q
Q
P
A
L
M
G
S
L
G
V
E
M
A
D
K
Y
L
K
G
E
K
I
P
N
-----
F
I
P
A
E
L
K
L
I
T
K
E
N
V
Q
-------------------------
24
HHSearch
56.97
15%
-43
- C1 -
3EGC
-
?
A:
[66-333]
------------------------------------
R
S
N
V
V
G
L
I
V
S
-
D
I--
E
N
V
F
F
A
E
V
A
S
G
-
V
E
S
E
A
R
H
K
G
Y
S
------
V
L
L
A
N
-
T
A
E
D
I
V
R
E
R
E
A
V
G
Q
F
F
E
--
R
R
V
D
--
G
L
I
L
A
P
S
E
----
G
EH
D
Y
--
L
-
R
T
E
L
P
----
K
T
F
P
I
V
A
V
N
R
E
L
R
I
----------
P
G
C
G
A
V
L
-
S
E
N
V
R
G
A
R
T
A
V
E
Y
L
I
A
R
---
G
-
H
-----
T
R
I
G
A
I
V
-
G
S
-
A
G
L
-
M
-
T
S
R
E
R
L
K
G
F
R
A
A
M
-
S
A
A
--
G
L
P
-----
V
-
R
Q
E
-
W
IAA--------
N
G
R
D
G
A
I
-
K
V
L
T
G---
D
-------
R
P
T
A
L
-
L
T
S
S
H
-
R
I
T
E
-
G
A
M
Q
A
L
-
N
V
L
G
L
R
YG
P
D
V
E
I
V
S
F
D
N
-
L
P
-----
W
-----
M
A
F
L
D
---
P
-
P
-
L
P
V
V
E
Q
P
T
R
R
I
G
Q
E
A
M
R
M
L
I
H
M
I
E
G
T
G
N
A
T
-----
E
M
R
L
Q
T
R
F
V
T
H
-----------------------------
43
HHSearch
56.70
14%
-50
- C1 -
3H5O
2
?
A:
[63-313]
--------------------------------------
R
T
V
L
V
L
I
P
-
S
L--
A
N
T
V
F
L
E
T
L
T
G
-
I
E
T
V
L
D
A
A
G
Y
Q
------
M
L
I
G
N
-
S
H
Y
D
A
G
Q
E
L
Q
L
L
R
A
Y
L
Q
--
H
R
P
D
--
G
V
L
I
T
G
L
S
----
H
AEP
F
--
E
-
R
I
L
S
Q
----
H
A
L
P
V
V
Y
M
M
-
D
L
A
D
----------
D
G
R
C
C
V
G
-
F
S
Q
E
D
A
G
A
A
I
T
R
H
L
L
S
R
---
G
-
K
-----
R
R
I
G
F
L
G
-
A
Q
-
L
-
D
-
E
-
R
V
M
K
R
L
D
G
Y
R
A
A
L
-
D
A
A
--
D
C
R
DAGL
E
W
-
L
D
P
-
Q
---
P
---
S
S
M
Q
M
G
A
D
M
L
D
-
R
A
L
A
E
R
--
P
-------
D
C
D
A
L
-
F
C
C
N
D
-
D
L
A
I
-
G
A
L
A
R
S
-
Q
Q
L
G
I
A
VP
E
R
L
A
I
A
G
F
N
D
-
L
Q
-----
P
-----
A
AW-
C
T--
P
-
P
-
L
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
G
E
E
P
A
S
R
-
R
A
D
L
G
F
R
L
M
L
R
R
S
S
E
G
---------------------------
37
HHSearch
56.50
15%
-55
- C1 -
2O20
3
?
A:
[62-313]
------------------------------------
R
T
T
T
V
G
V
I
L
P
-
T
I--
T
S
T
Y
F
A
A
I
T
R
G
-
V
D
D
I
A
S
M
Y
K
Y
N
------
M
I
L
A
N
-
S
D
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
--
K
Q
V
D
--
G
I
V
Y
M
G
S
S
----
L
D
E
K
I
--
R
-
T
S
L
K
N
----
S
R
T
P
V
V
L
V
G
T
I
-
D
G
D
---------
K
E
I
P
S
V
N
-
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
---
G
-
N
-----
K
K
I
A
Y
I
M
-
G
S
L
K
-
D
-
V
-
E
N
T
E
R
M
V
G
Y
Q
E
A
L
-
L
E
A
--
N
I
E
-----
F
-
D
E
N
-
L
VF-
E
GN-
Y
S
Y
E
Q
G
K
A
L
A
E
-
R
L
L
--
E
--
R
-------
G
A
T
S
A
-
V
V
S
H
D
-
T
V
A
V
-
G
L
L
S
A
M
-
M
D
K
G
V
K
VP
E
D
F
E
I
I
S
G
A
N
-
S
P
-----
I
-----
T
---
Q
YTY
P
-
T
-
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
D
V
E
Q
N
-
Q
L
V
L
D
H
E
I
F
S
R
R
S
T
K
----------------------------
33
HHSearch
55.16
15%
-58
- C1 -
3CTP
2
?
A:
[60-305]
-------------------------------------
S
K
T
I
G
L
M
V
P
-
N
I--
S
N
P
F
F
N
Q
M
A
S
V
-
I
E
E
Y
A
K
N
K
G
Y
T
------
L
F
L
C
N
-
T
D
D
D
K
E
K
E
K
T
Y
L
E
V
L
Q
S
--
H
R
V
A
--
G
I
I
A
S
R
S
Q
----
C
------
E
-
D
E
Y
A
N
----
I
D
I
P
V
V
A
F
E
N
H
-
I
L
----------
D
N
I
I
T
I
S
-
S
D
N
Y
N
G
G
R
M
A
F
D
H
L
Y
E
K
---
G
-
C
-----
R
K
I
L
H
I
K
-
G
P
-
E
V
F
-
E
-
A
T
E
L
R
Y
K
G
F
L
D
G
A
-
R
A
K
--
D
L
E
-----
I
-
D
F
I
-
E
---
F
QHD
F
Q
V
K
M
L
E
E
D
I
N
-
S
M
KD-
I
--
V
-------
N
Y
D
G
I
-
F
V
F
N
D
-
I
A
A
A
-
T
V
M
R
A
L
-
K
K
R
G
V
S
IP
Q
E
V
Q
I
I
G
F
D
N
-
S
F
-----
I
-----
G
E
L
L
Y
---
P
-
S
-
L
T
T
I
N
Q
P
I
E
A
L
A
Y
T
I
I
E
L
L
I
K
I
I
N
G
E
G
V
L
I
E
-
D
Y
I
M
E
V
K
L
I
E
R
E
T
T
I
S
---------------------------
34
HHSearch
54.83
13%
-61
- C1 -
2FEP
2
CCPA_BACSU
A:
[16-269]
-------------------------------------
T
T
T
V
G
V
I
I
P
-
D
I--
S
S
I
F
Y
S
E
L
A
R
G
-
I
E
D
I
A
T
M
Y
K
Y
N
------
I
I
L
S
N
-
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
--
K
Q
V
D
--
G
I
V
F
M
G
G
N
----
I
T
D
E
H
--
V
-
A
E
F
K
R
----
S
P
V
P
I
V
L
A
A
S
V
-
E
E
Q
---------
E
E
T
P
S
V
A
-
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
---
G
-
H
-----
T
D
I
A
F
V
S
-
G
P
-
M
-
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
-
E
E
A
--
N
L
P
-----
F
-
N
E
Q
F
V
A
E
G
D
---
Y
T
Y
D
S
G
L
E
A
L
Q
-
H
L
M
S
L
D
--
K
-------
K
P
T
A
I
-
L
S
A
T
D
-
E
M
A
L
-
G
I
I
H
A
A
-
Q
D
Q
G
L
S
IP
E
D
L
D
I
I
G
F
D
N
-
T
R
-----
L
-----
S
LMV
R
---
P
-
Q
-
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
-
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
----------------------------
36
HHSearch
54.74
13%
-55
- C1 -
1TJY
1
LSRB_SALTY
A:
[2-263]
------------------------------------
S
A
E
R
I
A
F
I
P
K
-
L
V--
G
V
G
F
F
T
S
G
G
N
G
-
A
Q
E
A
G
K
A
L
G
I
D
------
V
T
Y
D
G
P
T
E
P
S
V
S
G
Q
V
Q
L
V
N
N
F
V
N
--
Q
G
Y
D
--
A
I
I
V
S
A
V
S
----
P
DGL
C
P
A
L
-
K
R
A
M
Q
----
R
G
V
K
I
L
T
W
D
S
D
T
K
P
E
---------
C
R
S
Y
Y
I
N
Q
G
T
P
K
Q
L
G
S
M
L
V
E
M
A
A
H
Q
V
D
-
K
E
K
-----
A
K
V
A
F
F
Y
-
S
S
P
T
-
V
-
T
-
D
Q
N
Q
W
V
K
E
A
K
A
K
I
-
S
Q
E
HP
G
W
E
-----
I
-
V
T
T
-
Q
---
F
GY-
N
D
A
T
K
S
L
Q
T
A
E
-
G
I
I
K
A
Y
--
P
-------
D
L
D
A
I
-
I
A
P
D
A
-
N
A
L
P
-
A
A
A
Q
A
A
-
E
N
L
K
R
N
---
N
L
A
I
V
G
F
S
T
-
P
N
VM
R
P
Y
V
-----
Q
---
R
---
G
-
T
V
K
E
F
G
L
W
D
V
V
Q
Q
G
K
I
S
V
Y
V
A
N
A
L
L
K
N
M
P
M
N
V
G
-
D
S
L
D
I
P
G
I
G
K
V
T
V
S
P
N
S
E
Q
G
Y
H
Y
E
A
K
G
N
G
I
V
L
L
P
E
R
V
I
F
N
---
26
HHSearch
54.28
12%
-57
- C1 -
3D02
4
?
A:
[4-265]
-------------------------------------
E
K
T
V
V
N
I
S
K
-
V
D--
G
M
P
W
F
N
R
M
G
E
G
-
V
V
Q
A
G
K
E
F
N
L
N
----
A
S
Q
-
V
G
P
-
S
S
T
D
A
P
Q
Q
V
K
I
I
E
D
L
I
A
--
R
K
V
D
--
A
I
T
I
V
P
N
D
----
A
NVL
E
P
V
F
-
K
K
A
R
D
----
A
G
I
V
V
L
T
N
E
S
P
G
Q
P
S
---------
A
N
W
D
V
E
I
-
I
D
N
E
K
F
A
A
E
Y
V
E
H
M
A
K
R
M
G
-
G
-
K
-----
G
G
Y
V
I
Y
V
-
G
S
L
T
-
V
-
P
-
Q
H
N
L
W
A
D
L
L
V
K
Y
Q
-
K
E
H
YP
D
M
H
-----
E
-
V
T
R
-
R
MPV
A
---
E
S
V
D
D
S
R
R
T
T
L
-
D
L
M
K
T
Y
--
P
-------
D
L
K
A
V
-
V
S
F
G
S
-
N
G
P
I
-
G
A
G
R
A
V
-
K
E
K
R
A
K
--
N
K
V
A
V
Y
G
M
M
I
-
P
S
QA
A
S
L
I
-----
K
---
S
---
G
D
I
-
T
E
G
I
T
Y
D
P
A
T
A
G
Y
A
L
A
A
V
A
S
T
L
L
N
G
K
T
I
E
P
G
-
F
E
L
K
E
L
G
K
A
E
V
D
S
D
K
H
I
I
R
F
H
K
V
L
L
V
N
K
D
N
I
D
S
L
Y
--------
27
HHSearch
53.04
13%
-43
- C1 -
1JX6
2
LUXP_VIBHA
A:
[38-338]
--------------------------------
K
P
T
Q
R
P
I
K
I
S
V
V
Y
P
-
G
QQ-
V
S
D
Y
W
V
R
N
I
A
S
-
F
E
K
R
L
Y
K
L
N
I
N
--
Y
Q
L
N
Q
V
F
T
R
-
P
N
A
D
I
K
Q
Q
S
L
S
L
M
E
A
L
K
--
S
K
S
D
--
Y
L
I
F
T
L
D
T
----
T
R-----
H
R
K
F
V
E
H
V
L
D
S
T
N
T
K
L
I
L
Q
N
I
T
T
P
V
R
E
-
W
---
D
K
H
Q
P
F
L
Y
V
G
-
F
D
H
A
E
G
S
R
E
L
A
T
E
F
G
K
F
F
P
-
K
-
H
-----
T
Y
Y
S
V
L
Y
-
F
S
-
E
-
G
-
Y
-
I
S
D
V
R
G
D
T
F
I
H
Q
V
-
N
R
D
N-
N
F
E
-----
L
-
Q
S
A
-
Y
---
Y
T
K-
A
T
K
Q
S
G
Y
D
A
A
K
-
A
S
L
A
K
H
--
P
-------
D
V
D
F
I
-
Y
A
C
S
T
-
D
V
A
L
-
G
A
V
D
A
L
-
A
E
L
G
R
---
E
D
I
M
I
N
G
W
G
G
-
G
S
A
E
L
D
A
I
-----
Q
---
K
---
G
D
L
-
D
I
T
V
M
R
M
N
D
D
T
G
I
A
M
A
E
A
I
K
W
D
L
E
D
K
P
V
P
T
-----
V
Y
S
G
D
F
E
I
V
T
K
A
D
S
P
E
R
I
E
A
L
K
K
R
A
F
R
Y
S
D
----------
45
HHSearch
52.92
15%
-46
- C1 -
3CS3
5
?
A:
[5-269]
----------------------------------
R
R
Q
T
N
I
I
G
V
Y
L
A
-
D
Y--
G
G
S
F
Y
G
E
L
L
E
G
-
I
K
K
G
L
A
L
F
D
Y
E
------
M
I
V
C
S
-
G
K
K
S
H
-------
L
F
I
P
E
--
K
M
V
D
--
G
A
I
I
L
D
W
T
FP
T
K
E
------
I
-
E
K
F
A
E
----
R
G
H
S
I
V
V
L
D
R
T
T
E
H
----------
R
N
I
R
Q
V
L
-
L
D
N
R
G
G
A
T
Q
A
I
E
Q
F
V
N
V
---
G
-
S
-----
K
K
V
L
L
L
S
-
G
P
-
E
K
G
-
Y
-
D
S
Q
E
R
L
A
V
S
T
R
E
L
-
T
R
F
--
G
I
P
-----
Y
-
E
I
I
-
Q
---
G
D--
F
T
E
P
S
G
Y
A
A
A
K
-
K
I
L
S
-
Q
PQ
T
-------
E
P
V
D
V
-
F
A
F
N
D
-
E
M
A
I
-
G
V
Y
K
Y
V
-
A
E
T
N
Y
Q
MG
K
D
I
R
I
I
G
F
D
N
-
S
E
-----
L
-----
G
A
F
V
Q
---
P
-
R
-
L
A
T
I
A
Y
S
K
H
R
W
G
M
V
A
A
E
K
I
I
H
L
M
R
G
E
A
A
E
S
E
------
H
I
Y
T
R
F
I
E
G
E
S
F
P
S
------------------------
38
HHSearch
52.27
12%
-47
- C1 -
3BRS
-
?
A:
[5-266]
-------------------------------------
Q
Y
Y
M
I
C
I
P
K
-
V
LDD
S
S
D
F
W
S
V
L
V
E
G
-
A
Q
M
A
A
K
E
Y
E
I
K
----
L
E
F
M
A
P
E
-
K
E
E
D
Y
L
V
Q
N
E
L
I
E
E
A
I
K
--
R
K
P
D
--
V
I
L
L
A
A
A
D
YE--
K
TYDA--
A
-
K
E
I
K
D
----
A
G
I
K
L
I
V
I
D
S
G
M
K
Q
D
---------
I
A
D
I
T
V
A
-
T
D
N
I
Q
A
G
I
R
I
G
A
V
T
K
N
L
V
R
-
K
-
S
-----
G
K
I
G
V
I
S
-
F
V
-
K
N
S
-
K
-
T
A
M
D
R
E
E
G
L
K
I
G
L
-
S
D
D
--
S
N
K
-----
I
-
E
A
I
-
Y
---
Y
CD-
S
N
Y
D
K
A
Y
D
G
T
V
-
E
L
L
T
K
Y
--
P
-------
D
I
S
V
M
-
V
G
L
N
Q
-
Y
S
A
T
-
G
A
A
R
A
I
-
K
D
M
S
L
E
--
A
K
V
K
L
V
C
I
D
S
-
S
M
-----
E
Q--------
E
---
G
I
F
-
E
A
M
V
V
Q
K
P
F
N
I
G
Y
L
G
V
E
K
A
L
K
L
L
K
K
E
Y
V
P
K
Q
-
L
D
S
G
C
A
L
I
T
K
D
--------------------------------
31
HHSearch
50.45
10%
-47
- C1 -
3BIL
-
?
A:
[67-335]
---------------------------------------
T
I
G
V
I
V
P
-
S
L--
I
N
H
Y
F
A
A
M
V
T
E
-
I
Q
S
T
A
S
K
A
G
L
A
------
T
I
I
T
N
-
S
N
E
D
A
T
T
M
S
G
S
L
E
F
L
T
S
--
H
G
V
D
--
G
I
I
C
V
P
N
E
----
E
C
A
N
Q
--
L
-
E
D
L
Q
K
----
Q
-
M
P
V
V
L
V
D
R
E
L
P
G
D
----------
T
I
P
T
A
T
-
S
N
P
Q
P
G
I
A
A
A
V
E
L
L
A
H
N
---
N
-
A
-----
L
P
I
G
Y
L
S
-
G
P
M
D
-
T
-
S
-
T
G
R
E
R
L
E
D
F
K
A
A
C
-
A
N
S
--
K
I
G
-----
E
-
Q
L
V
-
F
---
L
GG-
Y
E
Q
S
V
G
F
E
G
A
T
-
K
L
L
--
D
--
Q
-------
G
A
K
T
L
-
F
A
G
D
S
-
M
M
T
I
-
G
V
I
E
A
C
-
H
K
A
G
L
V
IG
K
D
V
S
V
I
G
F
D
T
-
H
P
-----
L
F
A
L
--
Q
---
P
---
H
-
P
-
L
T
V
I
D
Q
N
V
E
Q
L
A
Q
R
A
V
S
I
L
T
E
L
-------------
T
-
T
I
P
T
A
L
I
H
R
E
S
I
I
N
S
-----------------------
44
HHSearch
48.66
8%
-44
- C1 -
3H75
3
?
A:
[3-309]
-------------------------------------
L
T
S
V
V
F
L
N
P
-
G
NS-
T
E
T
F
W
V
S
Y
S
Q
F
-
M
Q
A
A
A
R
D
L
G
L
D
------
L
R
I
L
Y
-
A
E
R
D
P
Q
N
T
L
Q
Q
A
R
E
L
F
Q
GR
D
K
P
D
--
Y
L
M
L
V
N
E
Q
----
Y
V
A
P
Q
I
-
L
-
R
L
S
Q
G
----
S
G
I
K
L
F
I
V
N
S
P
L
T
L
D
Q
R
--------
W
I
G
S
M
V
-
G
D
D
E
E
A
G
Y
R
M
L
K
E
L
L
H
K
L
G
-
P
-
V
PAG
H
G
I
E
L
L
A
F
S
G
L
K
-
V
-
T
-
P
-
A
A
Q
L
R
E
R
G
L
R
R
A
L
-
A
E
H
--
P
Q
V
H----
L
-
R
Q
L
-
V
---
Y
GE-
W
N
R
E
R
A
Y
R
Q
A
Q
-
Q
L
L
K
R
Y
--
P
-------
K
T
Q
L
V
-
W
S
A
N
D
-
E
M
A
L
-
G
A
M
Q
A
A
-
R
E
L
G
R
K
PG
T
D
L
L
F
S
G
V
N
S
-
S
P
E
A
L
Q
A
L
-----
I
---
D
---
G
-
K
-
L
S
V
L
E
A
G
H
F
T
L
G
G
W
A
L
V
A
L
H
D
D
A
L
G
L
D
A
R
R
L
G
G
P
D
W
Q
L
S
L
F
Q
A
L
T
P
A
Q
A
R
Q
L
L
R
L
G
D
Q
V
G
T
R
V
D
F
R
G
L
S
A
Q
G
---
29
HHSearch
48.00
13%
-42
- C1 -
3GYB
1
?
A:
[4-272]
------------------------------------
R
T
Q
L
I
A
V
L
I
D
D
Y
---
S
N
P
W
F
I
D
L
I
Q
S
-
L
S
D
V
L
T
P
K
G
Y
R
------
L
S
V
I
D
-
S
L
T
S
Q
-
A
G
T
D
P
I
T
S
A
L
S
--
M
R
P
D
--
G
I
I
I
A
Q
D
I
-----------------------
L
P
P
F
V
I
A
G
T
R
I
T
Q
A
---------
S
T
H
D
S
V
A
-
N
D
D
F
R
G
A
E
I
A
T
K
H
L
I
D
L
---
G
-
H
-----
T
H
I
A
H
L
R
-
V
G
-
S
---
G
-
A
G
L
R
R
F
E
S
F
E
A
T
M
-
R
A
H
--
G
L
E
-----
P
-
L
S
N
-
D
---
Y
LGP
A
V
E
H
A
G
Y
T
E
T
L
-
A
L
L
K
E
H
--
P
-------
E
V
T
A
I
-
F
S
S
N
D
-
I
T
A
I
-
G
A
L
G
A
A
-
R
E
L
G
L
R
VP
E
D
L
S
I
I
G
Y
D
N
-
T
P
-----
L
-----
A
QT-
R
L--
I
-
N
-
L
T
T
I
D
D
N
S
I
G
V
G
Y
N
A
A
L
L
L
L
S
M
L
D
P
E
A
P
H
P
E
-
I
--
M
H
T
L
Q
P
S
L
I
E
R
G
T
C
A
P
R
-----------------------
49
Fugue
44.81
15%
-25
- C1 -
3BBL
4
?
A:
[3-283]
L
S
F
M
I
G
Y
S
W
T
-------------------------------
Q
T
E
P
G
-
Q
---
V
N
H
I
L
D
Q
F
L
S
S
M
V
R
E
-
A
G
A
V
N
Y
F
------
V
L
P
F
P
-
F
S
E
D
R
S
Q
I
D
I
Y
R
D
L
I
R
S
--
G
N
V
D
G
F
V
L
S
S
I
N
Y
N
----
D
------
P
-
R
V
Q
F
L
L
K
--
Q
K
F
P
F
V
A
F
G
R
S
N
P
----------
D
W
D
F
A
W
V
D
-
I
D
G
T
A
G
T
R
Q
A
V
E
Y
L
I
G
--
R
-
G
-
H
-----
R
R
I
A
I
L
A
-
W
P
-
E
-
D
-
S
-
R
V
G
N
D
R
L
Q
G
Y
L
E
A
M
Q
T
A
--
Q
L
P
-----
I
E
T
G
Y
-
I
---
L
---
R
G
E
G
T
F
E
V
G
R
A
M
T
L
---
H
--
L
L
D
LSPER
R
P
T
A
I
M
T
L
N
D
T
M
A
I
G
A
M
A
A
A
R
E
R
G
L
T
I
G
T
D
--
L
A
I
I
G
F
D
D
A
P
M
V
Q
-----
Y
-----
L
---
F
---
P
-
P
-
L
S
S
V
R
Q
P
I
A
E
A
G
R
K
C
I
E
L
L
V
A
I
V
E
G
R
E
P
E
---------------------------
Q
K
H
I
L
L
Q
P
S
L
I
I
R
A
S
E
GHH