@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1275: (2015-12-06 )
MKARELIDVYETYCPQELSMEGDISGLQIGSLDKEIKTVMVALDVRETTVAEAIERQVDLLIVKHAPIFRPLKDLVATPQNKIYIDLLKSDIAVYVSHTNIDIVPNGLNDWFCELLDIQYPDILSETSNGYGIGRIGDVRPQSFEFFAWKIKDVFGLDSVRLVSYDKSNPEIQRVAICGGSGQSFYKEAIAKGADVFVTGDIYYHTAQEMITNGLLAIDPGHHIEVLFVSKIATMIEQWKLEKGWDISVLESKAPTNPFYHM
Atome Classification :
(20 SA)
----.........10........20........30..-.......40........50........60........70.....-.-..80........90........100.......110.......------------------------------------------------------------------------------------------------120..------------------------------------------------------------------------------------..---------.------------------------------------------------------------------------------------------------..130.......-140-.......150.......160.......170.......180--..--.....190.......200....---...210.......220.......230........240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
K
A
R
E
L
I
D
V
Y
E
TYCPQELSMEGDISG
L
Q
IG-
S
L
-
D
K
E
I
K
T
V
M
V
A
L
DV
R
E
T
T
V
A
E
A
I
E
RQV
D
L
L
I
VKHA
P
I
F
R
P
L
K
D
L
V-A-TPQN
K
I
Y
I
D
L
LKS
D
I
A
V
Y
V
SHT
N
I
D
I
VPNG
L
N
D
W
F
C
E
L
LDIQ------------------------------------------------------------------------------------------------YP
D
I
L
------------------------------------------------------------------------------------SE---------T------------------------------------------------------------------------------------------------SNGYGIGRIGDV-RPQ-S
F
E
F
F
A
W
K
I
K
DVFGLD
S
V
R
L
V
S
YDKSNP
E
I
Q
R
V
A
I
CGGS
G
--
Q
S
--
F
Y
K
E
A
I
AKGA
D
V
F
V
TG
D
I
Y
Y
H
T
---
A
Q
E
M
I
TN
G
L
L
A
IDPGH
H
I
E
V
L
F
V
S
-
K
I
A
T
M
I
E
QWKLEKGW
D
I
S
V
LESKAPTNPFYHM
73
HHSearch
80.50
36%
-131
- C7 -
2GX8
6
?
A:
[29-397]
----
P
N
G
H
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
E
G
D
K
I
G
L
Q
I
G
-
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
L
K
A
I
H
T
D
-
K
A
Y
G
K
I
I
E
K
C
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
G
G
V
N
D
L
L
A
E
A
L
G
L
Q
------------------------------------------------------------------------------------------------
N
T
E
V
L
------------------------------------------------------------------------------------
A
P
---------
T
Y
A
E
E
M
K
K
V
V
V
F
V
P
VTH
A
E
E
V
R
K
A
L
G
D
A
GAGHIGNYSH
C
T
F
S
S
E
G
T
G
T
F
V
P
QQ
L
E
R
V
E
E
V
R
I
E
T
I
I
P
ASL
Q
R
K
V
I
K
A
M
V
T
A
HPYE
E
V
A
Y
D
V
Y
P
L
DNK
G
E
T
L
G
L
G
K
I
G
Y
L
-
Q
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
L
D
V
K
G
A
R
V
V
--
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
--
N
K
--
Y
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
---
A
H
D
A
M
M
L
G
L
N
I
V
D
P
G
H
N
-
V
E
K
V
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
92
Fugue
79.38
35%
-138
- C7 -
2GX8
6
?
A:
[28-397]
---I
P
N
G
H
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
E
G
D
K
I
G
L
Q
I
G
-
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
L
K
A
I
H
-
T
D
K
A
Y
G
K
I
I
E
K
C
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
G
G
V
N
D
L
L
A
E
A
L
G
L
Q
NTEVLAPT
Y
A
E
E
M
K
K
V
V
V
F
V
P
VTH
A
E
E
V
R
K
A
L
G
D
A
GAGHIGNYSH
C
T
F
S
S
E
G
T
G
T
F
V
P
QQ
L
E
R
V
E
E
V
R
I
E
T
I
I
P
ASL
Q
R
K
V
I
K
A
M
V
T
A
HPYE
E
V
A
Y
D
V
Y
P
L
------------------------------------------------------------------------------------
D
N
---------
K
------------------------------------------------------------------------------------------------
G
E
T
L
G
L
G
K
I
G
Y
L
Q
E
E
M
-
T
L
G
Q
F
A
E
H
V
K
Q
S
L
D
V
K
G
A
R
V
V
G
--
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
--
N
K
--
Y
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
---
A
H
D
A
M
M
L
G
L
N
I
V
D
P
G
H
N
V
E
K
V
M
K
Q
-
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
93
Fugue
77.63
33%
-133
- C7 -
3LNL
3
GCH1L_STAAM
B:
[1-370]
AMDP
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
S
W
D
N
V
G
L
L
I
G
-
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
V
T
S
L
K
-
A
-
N
G
Y
G
L
I
I
R
K
L
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
H
G
V
N
M
M
L
A
K
V
M
G
L
K
------------------------------------------------------------------------------------------------
N
I
S
I
I
N
N
Q
Q
D
V
Y
Y
K
V
Q
T
Y
I
P
KDN
V
G
P
F
K
D
K
L
S
E
N
GLAQEY
C
F
F
E
S
E
G
R
G
QED
V
D
E
V
K
I
E
F
M
I
D
AYQ
K
S
R
A
E
Q
L
I
K
Q
YHPYET
P
V
F
D
F
I
E
I
K
---------
Q
------------------------------------------------------------------------------------------------
T
S
L
Y
G
L
G
V
M
A
E
V
D
N
Q
M
-
T
L
E
D
F
A
A
D
I
K
S
K
L
N
I
P
S
V
R
F
V
G
--
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
--
I
G
--
Y
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
---
A
L
D
A
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
-
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
74
HHSearch
75.99
33%
-125
- C7 -
2NYD
2
GCH1L_STAAM
A:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
S
W
D
N
V
G
L
L
I
G
-
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
V
T
S
L
K
A
N
-
G
Y
-
G
L
I
I
R
K
L
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
Y
G
V
N
M
M
L
A
K
V
M
G
L
K
------------------------------------------------------------------------------------------------
N
I
S
I
I
------------------------------------------------------------------------------------
N
N
Q
Q
D
V
Y
Y
K
V
Q-E
F
M
I
D
AYQ
K
S
R
A
E
Q
L
I
K
QT
P
V
F
D
F
I
E
I
K
Q
-------------------------------------------------------------------
T
S
L
Y
G
L
G
V
M
A
E
V
-
D
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
L
N
I
P
S
V
R
F
V
--
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
--
I
G
--
Y
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
---
A
L
D
A
K
I
H
G
V
N
L
I
D
I
N
H
Y
-
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
35
PsiBlast_CBE
66.63
35%
-122
- C7 -
3WSH
3
?
C:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
6
PsiBlast_PDB
66.52
35%
-124
- C7 -
3WSH
3
?
A:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
K
I
L
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
32
PsiBlast_CBE
66.44
35%
-124
- C7 -
3WSH
3
?
F:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
34
PsiBlast_CBE
66.21
35%
-124
- C7 -
3WSH
3
?
D:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
37
PsiBlast_CBE
66.11
35%
-127
- C7 -
3WSG
3
?
F:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
36
PsiBlast_CBE
66.11
35%
-124
- C7 -
3WSH
3
?
B:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
28
PsiBlast_CBE
66.04
35%
-124
- C7 -
3WSH
1
?
J:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
42
PsiBlast_CBE
65.90
35%
-125
- C7 -
3WSF
3
?
F:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
33
PsiBlast_CBE
65.90
35%
-122
- C7 -
3WSH
2
?
E:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
55
PsiBlast_CBE
65.87
35%
-126
- C7 -
3WSD
4
?
C:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
27
PsiBlast_CBE
65.73
35%
-122
- C7 -
3WSH
10
?
K:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
50
PsiBlast_CBE
65.71
35%
-126
- C7 -
3WSE
4
?
C:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
K
I
L
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
5
PsiBlast_PDB
65.58
35%
-122
- C7 -
3WSG
3
?
A:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
K
I
L
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
52
PsiBlast_CBE
65.48
35%
-123
- C7 -
3WSD
3
?
F:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------
76
HHSearch
65.47
33%
-113
* C7 *
3WSF
3
?
A:
[9-243]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
-
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
---
G
V
I
Y
K
K
L
K
I
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------
D
N
G
L
G
R
V
G
I
F
-
K
-
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
--
S
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
--
L
S
Q
S
S
I
K
Y
V
-
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
---
K
I
L
A
E
E
L
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
-------------
21
PsiBlast_CBE
65.47
35%
-124
- C7 -
3WSI
3
?
F:
[9-230]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
E
G
D
N
I
G
L
Q
V
G
D
N
L
-
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
I
R
N
F
T
-
G
-
V
I
Y
K
K
L
K
I
-
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
N
G
L
N
D
A
L
A
E
L
Y
N
L
E
------------------------------------------------------------------------------------------------
N
P
K
P
L
------------------------------------------------------------------------------------
Y
D
---------
N
----------------------------------------------------------------------------------------------------
G
L
G
R
V
G
-
I
-
F
K
G
-
S
F
E
E
F
L
E
I
T
K
K
Y
I
H
K
N
P
I
V
V
K
S
--
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
LS
Q
S
--
S
I
K
-
Y
V
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
KIL
A
E
E
L
---
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
G
L
-
K
K
F
K
E
F
L
S
S
N
L
D
L
E
I
I
S
L
D
F
------------