@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1276: (2015-12-06 )
MDLQLSKRLQKVANYVPKGARLLDVGSDHAYLPIFLLQMGYCDFAIAGEVVNGPYQSALKNVSEHGLTSKIDVRLANGLSAFEEADNIDTIAICGMGGRLIADILNNDIDKLQHVKTLVLQPNNREDDLRKWLAANDFEIVAEDILTENDKCYEILVVKHGHMNLTAKELRFGPLLLSNNTTVFKEKWQNELNKLTFALNSIPNSKMEERAILEDKIQDIKEVLDES
Atome Classification :
(20 SA)
-----------------.........10......-..20........30........40..-......50........60........70........80.-.-.-.....90.....-.-----.----.100.......110.......----------120..--.....130......--------.140.......150...-....160.--.......170.......180.......190...---....200.------..--..---.-..210-----.......220.....-----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------MD
L
Q
L
S
K
R
L
Q
K
V
A
N
YVP-KG
A
R
L
L
DVGSDH
A
Y
L
P
I
F
L
L
QMGYCD-
F
A
IAGEVVN
G
P
Y
Q
S
A
L
K
N
V
S
EHGLT
S
K
I
D
V
R
LANG
L
S
A
F
-
E
-E-ADNI
D
T
I
A
I
CGM-
G
-----
G
----
R
L
I
A
D
I
L
N
N
D
I
D
K
L
Q
H
V
K
T
L
V
----------LQPNN--
R
E
D
D
L
R
K
W
L
AAN
D
F
--------
E
I
V
A
E
D
ILTEND
K
C
Y
E
I
-
L
V
V
KHG-H--MNL
T
A
K
ELRF
G
P
L
L
LSNN
T
T
V
F
K
E
K
W
Q
N
E
L
N
K
L
---
T
F
A
L
N-SI------PN--
S
K
---
M
-
E
E
R
A
I
-----
L
E
D
K
I
Q
D
I
K
E
V
LDES-----------------------------------------------------------------
1
PsiBlast_PDB
96.57
61%
-106
- C2 -
3KR9
-
?
A:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
G
-
Q
I
------
P
E
--
K
N
---
L
-
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
19
PsiBlast_CBE
94.23
61%
-112
- C2 -
3KU1
1
?
B:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
20
HHSearch
94.16
60%
-102
- C2 -
3KR9
-
?
A:
[1-222]
--------------------
M
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
G
Q
I
P
------
E
K
--
N
L
------
E
E
R
Q
V
----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
15
PsiBlast_CBE
93.84
61%
-110
- C2 -
3KU1
1
?
H:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
17
PsiBlast_CBE
93.64
61%
-115
- C2 -
3KU1
1
?
D:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
18
PsiBlast_CBE
93.04
61%
-110
- C2 -
3KU1
1
?
C:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
16
PsiBlast_CBE
93.00
61%
-109
- C2 -
3KU1
1
?
G:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
2
PsiBlast_PDB
92.57
61%
-109
- C2 -
3KU1
1
?
A:
[2-222]
---------------------
I
S
K
R
L
E
L
V
A
S
F
V
S
-
Q
G
A
I
L
L
D
V
G
S
D
H
A
Y
L
P
I
E
L
V
E
R
G
Q
I
K
-
S
A
I
A
G
E
V
V
E
G
P
Y
Q
S
A
V
K
N
V
E
A
H
G
L
K
E
K
I
Q
V
R
L
A
N
G
L
A
A
F
-
E
-
E
-
T
D
Q
V
S
V
I
T
I
A
G
M
-
G
-----
G
----
R
L
I
A
R
I
L
E
E
G
L
G
K
L
A
N
V
E
R
L
I
----------
L
Q
P
N
N
--
R
E
D
D
L
R
I
W
L
Q
D
H
G
F
--------
Q
I
V
A
E
S
I
L
E
E
A
G
K
F
Y
E
I
-
L
V
V
E
A
G
-
Q
--
M
K
L
S
A
S
D
V
R
F
G
P
F
L
S
K
E
V
S
P
V
F
V
Q
K
W
Q
K
E
A
E
K
L
---
E
F
A
L
---------------------
E
E
R
Q
V
-----
L
V
D
K
I
Q
A
I
K
E
V
L
H
-------------------------------------------------------------------
22
HHSearch
71.17
47%
-44
- C2 -
3GNL
-
?
A:
[10-241]
-------------------
E
Q
L
S
K
R
L
E
K
V
A
S
Y
I
T
-
K
N
E
R
I
A
D
I
G
S
D
H
A
Y
L
P
C
F
A
V
K
N
Q
T
A
S
-
F
A
I
A
G
E
V
V
D
G
P
F
Q
S
A
Q
K
Q
V
R
S
S
G
L
T
E
Q
I
D
V
R
K
G
N
G
L
A
V
I
-
E
-
K
K
D
-
A
I
D
T
I
V
I
A
G
M
-
G
-----
G
----
T
L
I
R
T
I
L
E
E
G
A
A
K
L
A
G
V
T
K
L
I
----------
L
Q
P
N
I
--
A
A
W
Q
L
R
E
W
S
E
Q
N
N
W
--------
L
I
T
S
E
A
I
L
R
E
D
N
K
V
Y
E
I
-
M
V
L
A
P
S
E
K
P
-
V
T
W
T
K
Q
E
I
F
F
G
P
C
L
L
K
E
Q
S
A
I
F
K
S
K
W
R
H
E
A
N
T
W
---
Q
N
I
I
Q
T
I
S
N
-----
N
Q
PV
S
T
---
E
N
Q
A
K
I
R
E
----
L
E
H
K
I
A
L
V
E
D
V
L
K
E
G
-----------------------------------------------------------------
3
PsiBlast_PDB
69.41
46%
-42
- C2 -
3GNL
-
?
A:
[11-241]
--------------------
Q
L
S
K
R
L
E
K
V
A
S
Y
I
T
-
K
N
E
R
I
A
D
I
G
S
D
H
A
Y
L
P
C
F
A
V
K
N
Q
T
A
S
-
F
A
I
A
G
E
V
V
D
G
P
F
Q
S
A
Q
K
Q
V
R
S
S
G
L
T
E
Q
I
D
V
R
K
G
N
G
L
A
V
I
-
E
-
K
-
K
D
A
I
D
T
I
V
I
A
G
M
-
G
-----
G
----
T
L
I
R
T
I
L
E
E
G
A
A
K
L
A
G
V
T
K
L
I
----------
L
Q
P
N
I
--
A
A
W
Q
L
R
E
W
S
E
Q
N
N
W
--------
L
I
T
S
E
A
I
L
R
E
D
N
K
V
Y
E
I
-
M
V
L
A
P
S
-
E
K
P
V
T
W
T
K
Q
E
I
F
F
G
P
C
L
L
K
E
Q
S
A
I
F
K
S
K
W
R
H
E
A
N
T
W
---
Q
N
I
I
Q
-
T
I
------
S
N
--
N
Q
PVS
T
-
E
N
Q
A
K
I
R
E
--
L
E
H
K
I
A
L
V
E
D
V
L
K
E
G
-----------------------------------------------------------------
41
Fugue
67.40
43%
-36
- C2 -
3GNL
-
?
A:
[9-242]
------------------
E
E
Q
L
S
K
R
L
E
K
V
A
S
Y
I
T
-
K
N
E
R
I
A
D
I
G
S
D
H
A
Y
L
P
C
F
A
V
K
N
Q
T
A
S
-
F
A
I
A
G
E
V
V
D
G
P
F
Q
S
A
Q
K
Q
V
R
S
S
G
L
T
E
Q
I
D
V
R
K
G
N
G
L
A
V
I
-
E
-
K
-
K
D
A
-
I
D
T
I
V
I
A
G
M
G
-----
G
----
T
L
I
R
T
I
L
E
E
G
A
A
K
L
A
G
V
T
K
L
I
----------
L
Q
P
N
I
--
A
A
W
Q
L
R
E
W
S
E
Q
N
N
W
--------
L
I
T
S
E
A
I
L
R
E
D
N
K
V
Y
E
I
M
V
L
A
P
S
E
-
K
P
-
V
T
W
T
K
Q
E
I
F
F
G
P
C
L
L
K
E
Q
S
A
I
F
K
S
K
W
R
H
E
A
N
T
W
---
Q
N
I
I
Q
-
T
I
S
N
N
QPV
S
T
--
E
N
---
Q
-
A
K
I
R
E
-----
L
E
H
K
I
A
L
V
E
D
V
L
K
E
G
-----------------------------------------------------------------
9
PsiBlast_PDB
52.78
25%
-121
- C2 -
4C05
1
ANM6_MOUSE
A:
[78-186]
------------------------
R
L
G
I
L
K
N
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
L
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
R
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
V
A
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
M
E
S
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
D
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
A
R
------
A
G
--
L
E
---
Q
-
E
L
E
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
L
-----------------------------------------------------------------
14
PsiBlast_PDB
52.00
25%
-117
- C2 -
4Y30
4
ANM6_HUMAN
A:
[47-155]
------------------------
R
L
G
I
L
R
N
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
I
A
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
S
R
------
A
G
--
L
E
---
Q
-
E
L
Q
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
-----------------------------------------------------------------
10
PsiBlast_PDB
51.76
25%
-133
- C2 -
4HC4
1
ANM6_HUMAN
A:
[83-180]
-----------------------------------
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
I
V
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
S
R
------
A
G
--
L
E
---
Q
-
E
L
E
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
-----------------------------------------------------------------
12
PsiBlast_PDB
51.64
25%
-139
- C2 -
4QPP
2
ANM6_HUMAN
A:
[83-180]
-----------------------------------
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
I
V
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
S
R
------
A
G
--
L
E
---
Q
-
E
L
E
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
-----------------------------------------------------------------
11
PsiBlast_PDB
50.95
25%
-133
- C2 -
4QQK
6
ANM6_HUMAN
A:
[83-180]
-----------------------------------
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
I
V
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
S
R
------
A
G
--
L
E
---
Q
-
E
L
E
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
-----------------------------------------------------------------
42
Fugue
50.59
24%
-50
- C2 -
4QPP
3
ANM6_HUMAN
A:
[48-376]
YYEC
Y
S
D
V
S
V
H
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
G
I
L
R
N
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
-
A
R
-
R
V
Y
A
V
E
A
-
S
A
I
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
L
P
-
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
YGLLH
E
----
S
M
L
S
S
V
L
H
A
R
T
K
W
L
K
E
G
G
L
L
L
PA
S
A
E
L
F
I
V
P
I
S
D
Q
M
--
L
E
W
R
L
G
F
W
S
Q
V
K
Q
H
YGVDMSCL
E
G
F
A
T
R
C
L
M
G
H
S
---
E
I
-
V
V
Q
G
L
S
-
G
--
E
D
V
L
A
R
P
Q
R
F
A
Q
L
E
L
S
------
R
A
G
L
E
Q
E
L
E
A
G
V
G
G
R
F
R
C
S
-
C
Y
------
G
S
--
A
P
---
M
-
H
G
F
A
I
W
F
Q
V
T
F
P
G
G
E
S
E
K
P
L
V
L
S
T
S
PFHPATHWK
Q
A
L
L
Y
L
N
E
P
V
Q
V
E
QD
T
D
V
S
G
E
I
T
L
L
P
S
RDNPR
R
L
R
V
L
L
R
Y
K
V
G
DQ
E
E
K
T
K
D
F
A
M
ED
32
HHSearch
50.40
15%
-78
- C2 -
3E05
2
?
A:
[40-165]
-----------------------------------
D
D
L
V
M
W
D
I
G
A
G
S
A
S
V
S
I
E
A
S
N
L
M
P
N
G
-
R
I
F
A
L
E
R
N
P
Q
Y
L
G
F
I
R
D
N
L
K
K
F
V
A
R
-
N
V
T
L
V
E
A
F
A
P
E
G
L
-
D
D
L
-
P
-
D
P
D
R
V
F
I
G
G
S
-
G
-----
G
-----
M
L
E
E
I
I
D
A
V
D
R
R
L
K
S
E
G
V
I
V
----------
L
N
A
V
T
L
D
T
L
T
K
A
V
E
F
L
E
D
H
G
Y
--------
M
V
E
V
A
C
V
N
V
A
K
T
K
E
Y
K
M
-
F
E
S
H
N
P
-
V
--
Y
I
I
T
A
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.22
25%
-117
- C2 -
4Y2H
2
ANM6_HUMAN
A:
[48-156]
------------------------
R
L
G
I
L
R
N
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
S
I
F
C
A
Q
A
G
A
R
R
V
Y
A
V
E
A
S
A
I
---
W
Q
Q
A
R
E
V
V
R
F
N
G
L
E
D
R
V
H
V
-
L
P
G
P
V
E
T
V
-
E
-
L
-
P
E
Q
V
D
A
I
V
S
E
W
M
-
G
-----
Y
----
G
L
L
H
E
S
M
---
L
S
S
V
L
H
A
R
T
K
W
----------
L
K
E
G
G
--
L
L
L
P
A
S
A
E
L
F
I
A
P
I
--------
S
D
Q
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
-
H
Y
G
V
D
M
-
S
--
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
S
G
E
D
V
L
A
R
P
Q
R
F
---
A
Q
L
E
L
-
S
R
------
A
G
--
L
E
---
Q
-
E
L
E
A
G
-----
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
-----------------------------------------------------------------
31
HHSearch
49.50
17%
-66
- C2 -
3TM4
1
?
A:
[217-361]
-----------------------------------
D
G
G
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
G
-
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
Y
-
V
-
D
-
S
V
D
F
A
I
S
N
L
P
-
Y
-----
G
SM
I
P
D
L
Y
M
K
F
F
N
E
L
A
K
V
L
E
K
R
G
V
F
I
----------
T
T
E
-----
K
K
A
I
E
E
A
I
A
E
N
G
F
--------
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
-
Y
V
V
K
L
E
-
H
--
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------