@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1284: (2015-12-06 )
MIETKEEQERVILVGVELQDTENFEMSMEELASLAKTAGANVVNHYYQKRDKYDSKSFIGSGKLEEIKAIVEADEIDTVVVNNRLTPRQNSNLEAELGVKVIDRMQLILDIFAMRARSHEGKLQVHLAQLKYMLPRLVGQGIMLSRQAGGIGSRGPGESQLELNRRSIRHQISDIERQLKIVEKNRETVRERRVDSTTFKIGLIGYTNAGKSTIMNVLTDDKQYEANELFATLDATTKQIYLQNQFQVTLTDTVGFIQDLPTELVAAFKSTLEESRHVDLLLHVIDASDPNHEEHEKVVMEILKDLDMIDIPRLAIYNKMDVTEQLNATTFPNVRIAAKKQGSRDLLRRLIVDEIRHIFDEFSIRVHQNQAYKLYDLNKIALLDTYTFEEEYENITGYISPKQKWKLEEFYD
Atome Classification :
(20 SA)
.........10...---.....20........30.....---...40.-.......50........60........70........80........90......---.-.100.......110--------------.......120.......130.......140-........150--.....-..160.......170.......180.....-..190..-.....200........210....-..-.220.......230.......240.......250....---...260-..-....--.270..-.....-.280......--.290---.--......300..-.....310.-..-----------....320.....----.--.--------------330.---------......340....-----...350.......360-----------.......-------------------.370--......------.-380.......390......-.400......--.410-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIET
K
E
EQE
R
V
I
L
V
---
G
V
E
LQDTE
N
F
E
M
S
M
E
E
L
A
S
L
A
K
---TA
G
A
N
V
-
V
N
H
Y
Y
Q
K
R
DKYDSKSFIGSG
K
L
E
E
I
K
A
I
V
E
ADEI
D
T
V
V
VNNRLTPRQNSNL
E
A
E
L
---
G
-
V
K
V
I
D
R
M
Q
L
I
L
D
I
F
--------------
A
M
R
ARSHEG
K
L
Q
V
H
L
A
Q
L
K
Y
M
L
P
R
L
VGQ-
G
-
I
M
L
S
RQAGGIG--SRGPG-
E
S
Q
L
E
L
N
R
R
S
I
R
H
Q
I
S
D
I
E
R
Q
L
K
I
V
E
K
N
R
E
-
T
V
R
E
RRV-DS
T
T
F
K
-
I
G
L
I
G
YTNA
G
K
S
T
I
M
N
-
V
L-TDDKQY
E
A
N
E
L
F
ATLDAT
T
K
Q
I
Y
L
Q
N
Q
F
Q
V
T
L
T
D
T
V
G
F
---
I
Q
DL
P
T
-
E
L
-
V
A
A
F
--
K
S
-
T
L
E
-ESRH
V
-
D
L
L
L
H
V
IDAS--DP
N
H
---
E
--
E
H
E
K
V
V
M
E
I
L
K
-DLDMIDI
P
R
-
L
A
-----------
I
Y
NKMD
V
T
E
QLN----A--T--------------TFP
N
---------
V
R
I
A
AKKQG
S
R
D
L
-----
L
R
R
L
I
V
D
E
I
R
H
I
F
D
E------------F
S
I
R
V
HQ-------------------NQ
A
Y
--
K
L
Y
D
L
N
------
K
-
I
A
L
L
D
TY
T
F
E
E
E
YENI
T
G
Y-ISPKQ
K
W
K
L
E
--
E
FYD-------------------------------
3
PsiBlast_PDB
95.41
31%
-90
- C2 -
3KXI
3
HFLX_SULSO
A:
[16-357]
-----------------------------------
A
I
A
L
---
V
E
G
A
N
Y
K
V
T
S
I
Y
K
L
P
K
S
P
N
V
K
F
Y
I
Q
Y
D
K
L
Q
Q
I
K
---
N
D
E
E
I
S
T
L
I
I
F
E
Q
L
K
P
R
H
F
I
N
I
R
R
E
L
K--
G
-
K
E
V
L
D
K
I
L
L
L
L
E
I
F
--------------
A
L
H
A
G
S
K
E
A
K
M
Q
I
E
L
A
R
L
K
Y
E
L
P
-
I
I
K
E
-
T
-------------------V
E
S
T
I
K
F
Y
K
R
R
I
N
K
L
M
K
E
L
E
S
I
K
I
F
K
E
K
S
I
E
-
S
N
K
R
N
N
I
-
P
S
-----
I
G
I
V
G
Y
T
N
S
G
K
T
S
L
F
N
-
S
L
-
T
G
L
T
------------
P
K
R
Y
A
I
P
I
N
N
R
-
K
I
M
L
V
D
T
V
G
F
---
I
R
G
I
P
P
-
Q
I
-
V
D
A
F
--
F
V
-
T
L
S
-
E
A
K
Y
S
-
D
A
L
I
L
V
I
D
S
T
--
F
S
E
N
---
L
L
I
E
T
L
Q
S
S
F
E
I
L
R
-
E
I
G
V
S
G
K
P
I
-
L
V
T
LNKIDKINGD
L
Y
K
K
L
D
L
V
E
K
L
S
K
E
L
Y
S
--
P
--------------
I
F
D
V
---------
I
P
I
S
A
L
K
R
T
N
L
E
L
-----
L
R
----
D
K
I
Y
Q
L
A
T
Q
------------
L
S
L
--------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.71
31%
-87
- C2 -
2QTF
8
HFLX_SULSO
A:
[16-356]
-----------------------------------
A
I
A
L
---
V
E
G
A
N
Y
K
V
T
S
I
Y
K
L
P
K
S
P
N
V
K
F
Y
I
Q
Y
D
K
L
Q
Q
I
K
---
N
D
E
E
I
S
T
L
I
I
F
E
Q
L
K
P
R
H
F
I
N
I
R
R
E
L
K
--
G
-
K
E
V
L
D
K
I
L
L
L
L
E
I
F
--------------
A
L
H
A
G
S
K
E
A
K
M
Q
I
E
L
A
R
L
K
Y
E
L
P
-
I
I
K
E
-
T
---------------------
S
T
I
K
F
Y
K
R
R
I
N
K
L
M
K
E
L
E
S
I
K
I
--------------
I
-
P
S
-----
I
G
I
V
G
Y
T
N
S
G
K
T
S
L
F
N
-
S
L
-
T
G
L
-----------
M
S
P
K
R
Y
A
I
P
I
N
N
R
-
K
I
M
L
V
D
T
V
G
F
---
I
R
G
I
P
P
-
Q
I
-
V
D
A
F
--
F
V
-
T
L
S
-
E
A
K
Y
S
-
D
A
L
I
L
V
I
D
S
T
--
F
S
E
N
---
L
L
I
E
T
L
Q
S
S
F
E
I
L
R
-
E
I
G
V
S
G
K
P
I
-
L
V
T
LNKIDKINGD
L
Y
K
K
L
D
L
V
E
K
L
S
K
E
L
Y
S
--
P
--------------
I
F
D
V
---------
I
P
I
S
A
L
K
R
T
N
L
E
L
-----
L
R
----
D
K
I
Y
Q
L
A
T
Q
------------
L
S
---------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.11
31%
-87
- C2 -
2QTH
9
HFLX_SULSO
A:
[16-356]
-----------------------------------
A
I
A
L
---
V
E
G
A
N
Y
K
V
T
S
I
Y
K
L
P
K
S
P
N
V
K
F
Y
I
Q
Y
D
K
L
Q
Q
I
K
---
N
D
E
E
I
S
T
L
I
I
F
E
Q
L
K
P
R
H
F
I
N
I
R
R
E
L
K--
G
-
K
E
V
L
D
K
I
L
L
L
L
E
I
F
--------------
A
L
H
A
G
S
K
E
A
K
M
Q
I
E
L
A
R
L
K
Y
E
L
P
-
I
I
K
E
-
T
---------------------
S
T
I
K
F
Y
K
R
R
I
N
K
L
M
K
E
L
E
S
I
K
I
--------------
I
-
P
S
-----
I
G
I
V
G
Y
T
N
S
G
K
T
S
L
F
N
-
S
L
-
T
G
L
-----------
M
S
P
K
R
Y
A
I
P
I
N
N
R
-
K
I
M
L
V
D
T
V
G
F
---
I
R
G
I
P
P
-
Q
I
-
V
D
A
F
--
F
V
-
T
L
S
-
E
A
K
Y
S
-
D
A
L
I
L
V
I
D
S
T
--
F
S
E
N
---
L
L
I
E
T
L
Q
S
S
F
E
I
L
R
-
E
I
G
V
S
G
K
P
I
-
L
V
T
LNKIDKINGD
L
Y
K
K
L
D
L
V
E
K
L
S
K
E
L
Y
S
--
P
--------------
I
F
D
V
---------
I
P
I
S
A
L
K
R
T
N
L
E
L
-----
L
R
----
D
K
I
Y
Q
L
A
T
Q
------------
L
S
---------------------------------------------------------------------------------------------------------------
41
HHSearch
91.42
30%
-93
- C2 -
2QTF
8
HFLX_SULSO
A:
[9-354]
--------------------------
S
K
E
F
E
E
E
A
I
A
L
V
E
---
G
A
N
Y
K
V
-
T
S
I
Y
K
L
P
-
K
S
P
N
V
K
F
Y
I
Q
Y
D
K
L
Q
Q
I
K
N
D
---
E
E
I
S
T
L
I
I
F
E
Q
L
K
P
R
H
F
I
N
I
R
R
E
L
---
K
G
K
E
V
L
D
K
I
L
L
L
L
E
I
F
--------------
A
L
H
A
G
S
K
E
A
K
M
Q
I
E
L
A
R
L
K
Y
E
L
P
I
I
K
E
T
---------------------------
S
T
I
K
F
Y
K
R
R
I
N
K
L
M
K
E
L
E
S
I
K
I
---------------
I
P
S
-
I
G
I
V
G
Y
T
N
S
G
K
T
S
L
F
N
-
S
L
T
G
-
L
-----------
M
S
P
K
R
Y
A
I
P
I
N
-
N
R
K
I
M
L
V
D
T
V
G
F
---
I
R
G
I
P
P
-
Q
I
-
V
D
A
F
--
F
V
-
T
L
S
-
E
A
K
Y
S
-
D
A
L
I
L
V
I
D
S
T
--
F
S
E
N
L
L
-
I
--
E
T
L
Q
S
S
F
E
I
L
R
-
E
I
G
V
S
G
K
P
I
-
L
V
-----------
T
L
N
K
I
D
K
I
N
G
D
L
----
Y
--
K
K
L
D
L
V
E
K
L
S
K
E
L
YS
P
I
F
D
V
--------
I
P
I
S
A
L
K
R
T
N
L
E
L
-----
L
R
D
K
I
Y
Q
L
A
T
Q
L
S
-------------------------------------------------------------------------------------------------------------------------------
31
Fugue
86.47
29%
-63
- C2 -
2QTH
9
HFLX_SULSO
A:
[1-355]
------------------
M
K
T
A
A
L
F
V
S
K
E
F
E
E
E
A
I
A
L
V
E
---
G
A
N
Y
K
V
-
T
S
I
Y
-
K
L
P
K
S
P
N
V
K
F
Y
I
Q
Y
D
K
L
Q
Q
I
K
---
N
D
E
E
I
S
T
L
I
I
F
E
Q
L
K
P
R
H
F
I
N
I
R
R
E
L
---
K
G
K
E
V
L
D
K
I
L
L
L
L
E
I
F
--------------
A
L
H
A
G
S
K
E
A
K
M
Q
I
E
L
A
R
L
K
Y
E
L
P
I
I
K
E
---------------------------
T
S
T
I
K
F
Y
K
R
R
I
N
K
L
M
K
E
L
E
S
I
K
I
I
P
---------------
S
-
I
G
I
V
G
Y
T
N
S
G
K
T
S
L
F
N
-
S
L
-
T
-----------
G
L
M
S
P
K
R
Y
A
I
P
I
N
N
-
R
K
I
M
L
V
D
T
V
G
F
---
I
R
G
I
P
P
-
Q
I
-
V
D
A
F
--
F
V
-
T
L
S
-
E
A
K
Y
S
-
D
A
L
I
L
V
I
D
S
T
FS
E
N
L
L
---
I
--
E
T
L
Q
S
S
F
E
I
L
R
-
E
I
G
V
S
G
K
P
I
-
L
V
-----------
T
L
N
K
I
D
K
I
N
G
D
L
----
Y
--
K
--------------
K
L
D
L
---------
V
E
K
L
S
K
E
L
Y
S
-------------------------------------------------------------------
P
I
F
D
V
I
------
P
-
I
S
A
L
K
R
T
N
L
E
L
L
R
D
K
I
Y
Q
L
-
A
T
Q
L
S
------------------------------------------
44
HHSearch
65.63
27%
-74
- C2 -
1XZP
3
MNME_THEMA
A:
[157-405]
---------------------------------------------------------------------------------------------------------------------
A
V
R
D
L
I
--------------
E
--
A
K
S
E
T
S
-
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
-
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
-
E
--
I
E
T
N
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
-
A
G
---
I
L
-
L
N
R
G
L
R
-
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
-
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
-
G
I
L
F
R
I
V
D
T
A
G
V
---
R
S
E
-
T
N
-
D
L
-
V
E
R
L
G
I
E
R
-
T
L
Q
-
E
I
E
K
A
-
D
I
V
L
F
V
L
D
A
S
--
S
P
L
D
---
E
--
E
D
R
----
K
I
L
E
-
R
I
K
--
N
K
R
Y
-
L
V
-----------
V
I
N
K
V
D
V
V
E
K
I
N
----
E
--
E
E
I
K
N
K
L
G-------
T
D
R
H
M
--------
V
K
I
S
A
L
K
G
E
G
L
E
K
-----
L
E
E
S
I
Y
R
E
T
Q
E
I
F
E
R
------------
G
S
D
S
L
I
T
-------------------
N
L
R
Q
--
K
Q
L
L
E
N
------
V
-
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
-
A
S
I
D
L
E
R
A
L
N
--
L
L
D
E
-------------------------------
38
Fugue
64.73
19%
-23
- C2 -
1UDX
3
OBG_THET8
A:
[1-416]
--------------------------
M
F
Q
D
V
L
V
I
T
V
A
A
G
---
R
G
G
D
G
A
-
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
-------
V
D
S
L
S
R
L
S
K
R
T
Y
K
A
E
D
---
G
-
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
--------------
D
L
V
I
E
V
P
R
G
-
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
-
G
-
Q
T
V
L
V
A
R
G
G
A
G
----
G
R
G
-
N
M
H
F
V
----------
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
-
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
A
-
A
M
-
T
R
A
H
P
K
I
A
P
Y
P
F
T
T
L
S
P
N
L
G
V
V
E
V
S
E
E
E
R
F
T
L
A
D
I
P
G
I
---
I
E
G
-
A
S
-
E
G
-
K
G
L
G
--
L
E
-
F
L
R
-
H
I
A
R
T
-
R
V
L
L
Y
V
L
D
A
A
--
D
E
P
L
---
K
--
T
L
E
T
L
R
K
E
V
G
A
Y
D
P
A
L
L
R
R
P
S
-
L
V
-----------
A
L
N
K
V
D
L
L
E
E
E
A
----
V
--
K
--------------
A
L
A
D
A
L
A
R
E
G
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
-----
L
K
E
A
L
H
A
L
V
R
S
T
P
P
P
------------
E
M
P
K
P
V
P
-------------------
Q
A
G
V
--
E
V
V
P
V
A
------
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
-
L
M
E
A
A
G
Y
L
Q
E
--
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
GVRAG
D
L
V
R
I
GG
L
E
F
E
YIPEV
7
PsiBlast_PDB
63.87
24%
-58
- C2 -
2E87
3
?
A:
[140-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
I
D
D
R
L
R
Y
L
N
K
A
R
E
-
V
L
K
D
L
P
V
V
D
L
E
I
P
T
-
V
V
I
A
G
H
P
N
V
G
K
S
T
L
L
K
-
A
L
-
T
T
A
K
P
E
I
A
S
Y
P
F
T
T
R
G
I
N
V
G
Q
-
F
E
D
G
Y
F
R
Y
Q
I
I
D
T
P
G
L
---
L
D
R
P
I
S
-
E
R
-
N
E
I
E
--
K
Q
-
A
I
L
-
A
L
R
Y
L
G
N
L
I
I
Y
I
F
D
P
S
--
E
H
C
G
FP
L
E
--
E
Q
I
H
L
F
E
E
V
H
G
-
E
F
K
--
D
L
P
F
-
L
V
-----------
V
I
N
K
I
D
V
A
D
E
E
N
----
I
--
K
--------------
R
L
E
K
F
V
K
E
K
G
L
N
P
I
K
I
S
A
L
K
G
T
G
I
D
L
-----
V
K
E
E
I
I
K
T
L
R
P
L
A
E
K
------------
V
A
R
E
K
I
E
-------------------
R
E
L
R
--
R
Y
R
S
Y
----------------------------------------------------------------------------
36
Fugue
62.42
17%
-34
- C2 -
1XZP
3
MNME_THEMA
A:
[27-482]
--
S
S
V
D
K
L
M
D
T
I
V
A
VAT
P
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
K
I
V
Q
K
H
L
R
T
R
S
K
I
-
V
P
R
K
A
I
H
G
W
I
H
E
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
-
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
GKMD
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
-
R
E
L
I
E
V
L
A
E
I
R
--
V
E
L
D
Y
-
P
D
E
I
E
T
N
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
-
A
G
I
L
L
N
R
-
G
---
L
R
-
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
-
R
L
-
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
I
L
F
R
I
V
D
T
A
G
V
---
R
S
E
T
N
D
-
L
V
E
R
L
G
I
--
E
R
-
T
L
Q
-
E
I
E
K
A
-
D
I
V
L
F
V
L
D
A
S
--
S
P
L
D
---
E
--
E
D
R
K
I
L
E
R
I
K
N
-
K
R
Y
L
V
V
I
N
K
-
V
D
-----------
V
V
E
K
I
N
E
E
E
I
K
N
----
K
L
G
T
--------------
D
R
H
M
---------
V
K
I
S
A
L
K
G
E
G
L
E
K
-----
L
E
E
S
I
Y
R
E
T
Q
E
I
F
E
R
G
S
DSLITN
L
R
Q
K
Q
L
L
E
N
V
K
-------------------
G
H
L
E
--
D
A
I
K
S
L
K
E
GMPV
D
-
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
-
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
GK-----------------------------
5
PsiBlast_PDB
62.23
29%
-91
- C2 -
1XZQ
-
?
A:
[244-411]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
-
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
-
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
-
I
L
F
R
I
V
D
T
A
G
V
RSE
T
N
D
L
V
E
-
R
L
---
G
I
--
E
R
-
T
L
Q
-
E
I
E
K
A
-
D
I
V
L
F
V
L
D
A
S
--
S
P
L
D
---
E
--
E
D
R
K
I
--------
L
E
R
I
K
N
K
R
Y
L
V
-----------
V
I
N
K
V
D
V
V
E
K
I
N
----
E
--
E
--------------
E
I
K
N
K
L
GTDRH
M
-
V
K
I
S
A
L
K
G
E
G
L
E
K
-----
L
E
E
S
I
Y
R
E
T
Q
E
I
F
E
R
------------
G
S
D
S
L
I
T
-------------------
N
L
R
Q
--
K
Q
L
L
E
N
------
V
-
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
-
A
S
I
D
L
E
R
A
L
N
--
L
L
D
E
-------------------------------
4
PsiBlast_PDB
61.88
29%
-98
- C2 -
1XZP
3
MNME_THEMA
A:
[244-411]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
-
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
-
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
-
I
L
F
R
I
V
D
T
A
G
V
RSE
T
N
D
L
V
E
-
R
L
---
G
I
--
E
R
-
T
L
Q
-
E
I
E
K
A
-
D
I
V
L
F
V
L
D
A
S
--
S
P
L
D
---
E
--
E
D
R
K
I
--------
L
E
R
I
K
N
K
R
Y
L
V
-----------
V
I
N
K
V
D
V
V
E
K
I
N
----
E
--
E
--------------
E
I
K
N
K
L
GTDRH
M
-
V
K
I
S
A
L
K
G
E
G
L
E
K
-----
L
E
E
S
I
Y
R
E
T
Q
E
I
F
E
R
------------
G
S
D
S
L
I
T
-------------------
N
L
R
Q
--
K
Q
L
L
E
N
------
V
-
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
-
A
S
I
D
L
E
R
A
L
N
--
L
L
D
E
-------------------------------
13
PsiBlast_PDB
61.67
24%
-50
- C2 -
4A9A
-
RBG1_YEAST
A:
[68-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
F
V
G
F
P
S
V
G
K
S
T
L
L
S
-
K
L
-
T
G
T
E
S
E
A
A
E
Y
E
F
T
T
L
-
V
T
V
P
G
V
I
R
Y
K
G
A
K
I
Q
M
L
D
L
P
G
I
---
I
-
D
G
-------
G
R
G
--
K
Q
-
V
I
A
-
V
A
R
T
C
-
N
L
L
F
I
I
L
D
V
N
--
K
P
L
H
-------
H
K
Q
I
---
I
E
K
-
E
L
E
G
V
G
I
-------------------------
R
L
N
----
K
--
T
--------------
P
-
P
D
---------
I
L
I
K
K
K
E
K
G
G
I
S
I
T
N
T
VP
L
T
H
L
G
N
D
E
I
R
A
V
M
S
E
------------
Y
R
I
N
S
A
E
I
A
F
RCDAT
V
D
D
L
I
D
V
L
E
AS
S
R
R
Y
M
P
A
I
Y
V
L
N
------
K
-
I
D
S
L
S
I
E
E
L
E
L
L
Y
R
I
P
N
A
V
P
I
S
S
G
Q
D
W
N
L
D
--
E
L
L
Q
-------------------------------
54
HHSearch
61.56
22%
-100
- C2 -
1MKY
3
DER_THEMA
A:
[2-166]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
-
K
L
V
K
--------------
D
P
V
Q
D
T
V
E
W
Y
-
G
K
T
F
K
L
V
D
T
C
G
V
---
F
D
N
P
Q
D
-
I
I
-
S
Q
K
M
--
K
E
V
T
L
N
-
M
I
R
E
A
-
D
L
V
L
F
V
V
D
G
K
--
R
G
I
T
---
K
--
E
D
E
-
S
L
A
D
F
L
R
-
K
S
---
T
V
D
T
-
I
L
-----------
V
A
N
K
A
E
N
L
R
E
F
E
----
R
--
E
V
K
P
E
L
Y
S
L------
G
F
G
E
P
--------
I
P
V
S
A
E
H
N
I
N
L
D
T
-----
M
L
E
T
I
I
K
K
L
E
E
K
G
L
D
------------
L
E
S
K
P
E
I
-------------------
T
D
A
I
--
K
V
A
I
V
G
------
R
-
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
-
V
S
P
I
P
V
D
D
E
V
--
F
I
D
G
-------------------------------
42
HHSearch
59.94
22%
-52
- C2 -
3GEH
4
MNME_NOSS1
A:
[122-385]
-----------------------------------------------------------------------------------
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
---
G
--------------------------------
A
R
S
P
Q
A
-
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
-
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
E
E
--
D
L
P
P
L
D
D
E
A
I
I
S
D
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
-
K
G
E
L
L
----
R
T
G
L
K
-
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
-
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
G
-
G
I
P
V
Q
V
L
D
----------------------------
Q
-
A
A
N
T
A
-
D
L
V
L
L
T
I
D
A
A
--
T
G
W
T
---
T
--
G
D
Q
E
----
I
Y
E
-
Q
V
--
K
H
R
P
L
-
I
L
-----------
V
M
N
K
I
D
L
V
E
K
Q
L
----
I
--
T
SLEYPE--------
N
I
T
Q
I
--------
V
H
T
A
A
A
Q
K
Q
G
I
D
S
-----
L
E
T
A
I
L
E
I
V
Q
T
G
K
V
Q
------------
A
A
D
M
D
L
A
-------------------
I
N
Q
R
--
Q
A
A
A
L
T
------
Q
-
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
-
F
W
T
I
D
L
R
G
A
I
--
Q
A
L
G
-------------------------------
45
HHSearch
59.79
21%
-81
* C2 *
3IEV
2
ERA_AQUAE
A:
[9-182]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
G
Y
-
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
-
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
I
---
Y
E
P
K
K
S
D
V
L
-
G
H
S
M
V
-
E
I
-
A
K
Q
-
S
L
E
E
A
-
D
V
I
L
F
M
I
D
A
T
--
E
G
W
R
---
P
--
R
D
E
E
I
Y
Q
N
F
I
K
-
P
---
L
N
K
P
V
-
I
V
-----------
V
I
N
K
I
D
K
I
G
P
A
K
----
N
V-
L
P
L
I
D
E
I
H
K
K
HP---
E
L
T
E
I
--------
V
P
I
S
A
L
K
G
A
N
L
D
E
-----
L
V
K
T
I
L
K
Y
L
P
E
G
E
P
L
------------
F
P
E
D
M
I
T
-------------------
D
L
P
L
--
R
L
L
A
A
E
------
I
-
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
-
K
I
N
E
I
K
P
G
D
A
--
N
P
N
M
-------------------------------
58
HHSearch
58.82
25%
-67
- C2 -
2E87
1
?
A:
[166-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
T
-
V
V
I
A
G
H
P
N
V
G
K
S
T
L
L
K
-
A
L
T
T
A
-
K
P
E
I
A
S
Y
P
F
T
T
R
G
I
N
V
G
Q
F
E
D
-
G
Y
F
R
Y
Q
I
I
D
T
P
G
L
---
L
D
R
P
I
S
-
E
R
-
N
E
I
E
--
K
Q
-
A
I
L
A
L
R
Y
L
G
-
N
L
I
I
Y
I
F
D
P
S
--
E
H
C
G
---
F
P
L
E
E
Q
I
H
L
F
E
E
V
H
-
G
E
F
-
K
D
L
P
F
-
L
V
-----------
V
I
N
K
I
D
V
A
D
E
E
N
----
I
--
K
R
L
E
K
F
V
K
E
------
K
G
L
N
P
--------
I
K
I
S
A
L
K
G
T
G
I
D
L
-----
V
K
E
E
I
I
K
T
L
R
P
L
A
E
K
------------
V
A
R
E
K
I
E
-------------------
R
E
L
R
--
R
Y
R
S
Y
----------------------------------------------------------------------------
43
HHSearch
58.34
20%
-79
- C2 -
3GEE
1
MNME_CHLTE
A:
[152-399]
--------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
E
S
A
-
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
-
L
R
E
Q
L
I
R
S
C
A
L
I
E
LE
L
D
F
S
E
-
E
D
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
-
H
G
R
---
I
-
V
S
E
G
V
S
-
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
-
T
L
L------------------
E
E
C
F
I
H
D
-
K
T
M
F
R
L
T
D
----------------------------
M
-
K
M
A
E
A
-
D
L
I
L
Y
L
L
D
L
G
--
T
E
R
L
---
D
--
D
E
L
T
E
I
R
E
L
K
A
-
A
H
--
P
A
A
K
F
-
L
T
-----------
V
A
N
K
L
D
R
A
A
N
A
D
----
A
--
L
I
R
A
I
A
D
G
-------
T
G
T
E
V
--------
I
G
I
S
A
L
N
G
D
G
I
D
T
-----
L
K
Q
H
M
G
D
L
V
K
N
L
D
K
L
------------
H
E
A
S
V
L
V
-------------------
T
S
L
R
--
H
Y
E
A
L
R
------
N
-
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
-
L
I
A
F
E
L
R
A
A
L
--
D
Y
V
G
-------------------------------
62
HHSearch
57.38
22%
-60
- C2 -
2WJG
1
FEOB_METJA
A:
[6-169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
Y
E
-
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
-
A
L
T
G
E
-
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
E
F
E
Y
N
-
G
E
K
F
K
V
V
D
L
P
G
V
---
Y
S
L
T
A
N
-
S
I
-
D
E
I
I
--
A
R
-
D
Y
I
-
I
N
E
K
P
-
D
L
V
V
N
I
V
D
A
T
--
A
L
E
R
---
N
--
L
---
Y
L
T
L
Q
L
M
-
E
M
---
G
A
N
L
-
L
L
-----------
A
L
N
K
M
D
L
A
K
S
L
G
----
I
--
E
ID
V
D
K
L
E
K
I
-----
L
G
V
K
V
--------
V
P
L
S
A
A
K
K
M
G
I
E
E
-----
L
K
K
A
I
S
I
A
V
K
D
K
--------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
56.94
20%
-60
- C2 -
2GJ8
5
MNME_ECOLI
A:
[4-164]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
-
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
-
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
-
G
M
P
L
H
I
I
D
T
A
G
L
---
R
E
A
S
D
E
-
V
E
-
R
I
G
I
--
E
R
-
A
W
Q
-
E
I
E
Q
A
-
D
R
V
L
F
M
V
D
G
T
--
T
T
D
A
---
V
--
D
P
A
E
I
W
P
E
F
I
A
-
R
L
P
-
A
K
L
P
I
-
T
V
-----------
V
R
N
K
A
D
I
T
G
E
T
L
----
G
--
M
S
E
V
-----------
N
G
H
A
L
--------
I
R
L
S
A
R
T
G
E
G
V
D
V
-----
L
R
N
H
L
K
Q
S
M
-----------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
56.84
20%
-70
- C2 -
1WF3
4
ERA_THET8
A:
[6-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
G
F
-
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
-
N
L
L
G
V
K
V
A
P
I
S
P
R
P
Q
T
T
R
K
R
L
R
G
I
L
T
E
-
G
R
R
Q
I
V
F
V
D
T
P
G
L
---
H
K
P
M
-
D
-
A
L
-
G
E
F
M
D
-
Q
E
-
V
Y
E
-
A
L
A
D
V
-
N
A
V
V
W
V
V
D
L
R
--
H
P
P
T
---
P
--
E
D
-
E
L
V
A
R
A
L
K
-
P
L
V
-
G
K
V
P
I
-
L
L
-----------
V
G
N
K
L
D
A
A
K
Y
P
E
----
E
--
A
M
K
A
Y
H
E
L
L
------
P
E
A
E
P
--------
R
M
L
S
A
L
D
E
R
Q
V
A
E
-----
L
K
A
D
L
L
A
L
M
P
E
G
P
F
F
------------
Y
P
E
D
Y
A
K
-------------------
S
D
Q
T
--
F
G
E
W
V
A
------
E
-
I
L
R
E
E
A
M
K
R
L
W
H
E
V
P
Y
A
V
A
-
T
K
V
E
E
V
A
E
R
E
--
N
G
V
L
-------------------------------