@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1285: (2015-12-06 )
MRKIKLIAVVGPTAVGKTALGIELAKTFNGEIISGDSQQVYQKLDIGTAKASKEEQEQAYHHLIDVREVNENYSVYDFVKEAKVAIDTIISKGKIPIIVGGTGLYLQSLFEGYHLGGEVNQETLKAYREKLESLSDEDLFEKLTEQSIVIPQVNRRRAIRALELAKFGNDLQNSESPYDVLLIGLNDDRQVLYDRINRRVDLMIDNGLLDEAKWLYDNYPSVQASRGIGYKELFPYFSKQIPLEEAVDKLKQNTRRFAKRQLTWFRNRMNVEFIMVGEENYQQKIKRKVSDFLSSK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.-......130.......140....--------...150.----.-------.....160..----...-------..170..---..--------...180....-.-.-.190.......200.......210....---.-.-.---------220---.......----..230.......240........250.......260.......------270-------.......280--..--......290....-----------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
K
I
K
L
I
A
V
VGPTAVGK
T
A
L
G
I
E
L
A
K
TFNGEIISG
D
S
Q
Q
V
Y
Q
K
LDIGTAKA
S
K
E
E
Q
E
Q
A
Y
H
H
L
I
D
V
R
E
VNENY
S
V
Y
D
F
V
K
E
A
K
V
A
I
D
T
I
ISKGK
I
P
I
I
VG
G
T
G
L
Y
L
Q
S
L
F
E
G
YHLGGEV
N
Q
E
T
-
L
K
A
Y
R
E
K
L
E
SL
S
D
E
D
L
F
E
K
L
T
EQ--------SIVIPQV----N-------
R
R
R
A
I
R
A
L
E
L
----
A
K
F-------GNDLQNS---ES--------P
Y
D
V
L
L
I
GLN-D-
D
-
R
Q
V
L
Y
D
R
IN
R
R
V
D
L
M
IDNGLL
D
E
A
K
W
L
Y---D-N-Y---------P-----SVQASRG----I
G
Y
K
E
L
F
P
Y
F
S
KQI-
P
L
E
E
A
V
D
K
L
K
Q
N
T
R
R
F
A
K
R
Q
L
T
W
F
RNRM------
N
V
E
-------
F
I
M
VG
E
E
N
Y
---
Q
Q
--
K
I
K
R
K
V
S
D
F
LSSK-----------------------------------------------------------------------------------
1
PsiBlast_PDB
98.63
44%
-93
- C2 -
2QGN
1
MIAA_BACHD
A:
[2-308]
--
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
---------------------------------------------------------------------------------------
E
T
---
P
S
--------
P
Y
N
L
V
M
I
G
L
T
-
M
-
E
-
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
---
D
R
G
-
I
---------
R
-----
D
C
Q
S
V
Q
A
----
I
G
Y
K
E
M
Y
D
Y
L
D
G
N
V
-
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
A
------
N
V
T
-------
W
F
D
M
T
D
V
D
F
---
D
K
--
K
I
M
-
E
I
H
N
F
I
A
G
K
-----------------------------------------------------------------------------------
30
HHSearch
87.25
31%
-83
- C2 -
3CRM
-
MIAA_PSEAE
A:
[3-318]
-
S
L
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
-------------------------------------------------------------------------------------------------
L
--------
P
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
-
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
---
A
R
S
D
L
H--------
A
-----
G
L
P
S
I
R
A
----
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
-------
W
M
D
S
L
A
G
D
N
---
L
P
--
R
A
L
R
Y
L
K
T
V
S
I
L
A
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
86.61
33%
-72
- C2 -
3FOZ
-
MIAA_ECOLI
A:
[11-295]
----
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
D
P
E
V
-----
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
----
D
-------
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
-------
L
T
E
L
T
Q
T
---
S
G
D
A
L-----
P
Y
Q
V
H
Q
F
A
I
A
-
P
A
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
-
L
-
H
---------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
---
A
R
--
D
E
V
L
Q
V
V
-----------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.31
33%
-71
- C2 -
2ZXU
2
MIAA_ECOLI
A:
[11-295]
----
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
D
P
E
V
-----
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
----
D
-------
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
-------
L
T
E
L
T
Q
T
---
S
G
DAL-----
P
Y
Q
V
H
Q
F
A
I
A
-
P
A
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
-
L
-
H
---------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
---
A
R
--
D
E
V
L
Q
V
V
G
A
I
--------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.95
33%
-70
- C2 -
2ZM5
-
MIAA_ECOLI
A:
[11-295]
----
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
D
P
E
V
-----
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
VD
P
V
A
A
A
R
I
H
P
N
----
D
-------
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
-------
L
T
E
L
T
Q
T
---
S
G
DAL-----
P
Y
Q
V
H
Q
F
A
I
A
-
P
A
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
RG
D
-
L
-
H
---------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
---
A
R
--
D
E
V
L
Q
V
V
G
A
I
--------------------------------------------------------------------------------------
48
Fugue
85.78
31%
-77
- C2 -
3EPH
6
MOD5_YEAST
A:
[1-409]
--
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
Y
HPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
Y
K
T
GKK
P
S
E
T
F
N
E
Q
K
I
---
T
L
--------
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
S
QNKFTPEQ
C
-----
E
N
G
V
W
Q
V
----
I
G
F
K
E
F
L
P
W
L
T
V
---
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
I
KGD
I
Y
L
L
D
A
T
D
L
S
Q
W
---
D
T
--
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
NRPIKQERAPKALEELLSKGETTMKKLDDW
T
H
Y
T
CNVCRNADGK
N
V
V
A
I
G
E
K
Y
W
K
I
H
L
G
S
R
R
H
K
S
N
L
K
R
N
T
R
Q
A
D
F
E
K
W
K
I
21
PsiBlast_CBE
85.66
33%
-70
- C2 -
3FOZ
2
MIAA_ECOLI
B:
[11-295]
----
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
D
P
E
V
-----
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
----
D
-------
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
-------
L
T
E
L
T
Q
T
---
S
G
DAL-----
P
Y
Q
V
H
Q
F
A
I
A
-
P
A
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
-
L
-
H
---------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
---
A
R
--
D
E
V
L
Q
V
V
-----------------------------------------------------------------------------------------
26
PsiBlast_CBE
85.61
32%
-84
- C2 -
3EPH
4
MOD5_YEAST
B:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
YHPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
FNEQKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
22
PsiBlast_CBE
85.56
33%
-71
- C2 -
2ZXU
2
MIAA_ECOLI
B:
[11-295]
----
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
D
P
E
V
-----
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
LQEVD
P
V
A
A
A
R
I
H
P
N
----
D
-------
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
-------
L
T
E
L
T
Q
T
---
S
G
DAL-----
P
Y
Q
V
H
Q
F
A
I
A
-
P
A
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
-
L
-
H
---------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
---
A
R
--
D
E
V
L
Q
V
V
-----------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.24
32%
-83
- C2 -
3EPH
5
MOD5_YEAST
A:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
Y
HPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
F
N
E
QKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
29
HHSearch
84.33
32%
-66
- C2 -
3FOZ
-
MIAA_ECOLI
A:
[8-311]
-
S
L
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
--
P
L
P
S
A
D
P
-
E
V
R
A
R
I
E
Q
Q
A
A
E
-
Q
G
W
E
S
L
H
R
Q
L
--------
Q
E
V
D
P
V
A
----
A
A
R
I
HPND
P
Q
R
L
S
R
A
L
E
V
----
F
F
I
SGKT---
L
T
E
L
T
Q
T
S
G
D
A
L
--------
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
---
A
R
G
D
L
H--------
T
-----
D
L
P
S
I
R
C
----
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
-------
W
L
D
S
E
K
P
E
Q
A
--
R
D
--
E
V
L
Q
V
V
------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.32
32%
-84
- C2 -
3EPK
6
MOD5_YEAST
B:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
YHPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
FNEQKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
8
PsiBlast_PDB
84.10
32%
-82
- C2 -
3EPK
4
MOD5_YEAST
A:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
Y
HPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
F
N
E
QKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
83.67
31%
-78
- C2 -
3CRM
-
MIAA_PSEAE
A:
[8-301]
------
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
--------------------------------------------------------------------------------------------------L-------
P
Y
T
V
A
Q
L
A
I
A
-
P
-
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
RS
D
-
L
-
H
---------
A
-----
G
L
P
S
I
R
A
----
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
-------
W
M
D
S
L
A
G
D
N
---
L
P
--
R
A
L
R
Y
L
K
T
V
S
I
L
A
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
83.42
31%
-79
- C2 -
3CRR
4
MIAA_PSEAE
A:
[8-301]
------
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
--------------------------------------------------------------------------------------------------L-------
P
Y
T
V
A
Q
L
A
I
A
-
P
-
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
RS
D
-
L
-
H
---------
A
-----
G
L
P
S
I
R
A
----
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
-------
W
M
D
S
L
A
G
D
N
---
L
P
--
R
A
L
R
Y
L
K
T
V
S
I
L
A
-----------------------------------------------------------------------------------
25
PsiBlast_CBE
83.35
32%
-78
- C2 -
3EPJ
3
MOD5_YEAST
B:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
YHPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
FNEQKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
12
PsiBlast_PDB
82.28
31%
-79
- C2 -
3CRQ
2
MIAA_PSEAE
A:
[8-301]
------
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
--------------------------------------------------------------------------------------------------L-------
P
Y
T
V
A
Q
L
A
I
A
-
P
-
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
RS
D
-
L
-
H
---------
A
-----
G
L
P
S
I
R
A
----
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
-------
W
M
D
S
L
A
G
D
N
---
L
P
--
R
A
L
R
Y
L
K
T
V
S
I
L
A
-----------------------------------------------------------------------------------
31
HHSearch
82.24
32%
-73
- C2 -
3EPH
5
MOD5_YEAST
A:
[2-328]
---
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
--
D
T
K
S
S
E
R
K
L
T
R
K
Q
L
D
-
I
L
E
S
-
T
D
P
D
V
I
Y
N
T
L
--------
V
K
C
D
P
D
I
----
A
T
K
Y
HPND
Y
R
R
V
Q
R
M
L
E
I
----
Y
Y
K
T
GKK---
P
S
E
T
F
N
E
QKI
T
L
--------
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
Y
-
S
QNKFTPEQ-
C
-----
E
N
G
V
W
Q
V
----
I
G
F
K
E
F
L
P
W
L
T
---V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
KG
D
I
Y
-------
L
L
D
A
T
D
L
S
Q
WDT
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
N
R
-----------------------------------------------------------------------------------
7
PsiBlast_PDB
82.00
32%
-76
- C2 -
3EPJ
2
MOD5_YEAST
A:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
Y
HPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
F
N
E
QKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------
23
PsiBlast_CBE
79.13
32%
-73
- C2 -
3EPL
2
MOD5_YEAST
B:
[3-289]
----
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
-
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
--------
D
P
D
I
A
T
K
YHPN
D
-------
Y
R
R
V
Q
R
M
L
E
I
----
Y
-
Y
-------
K
T
G
K
K
P
S
---
E
T
FNEQKITL
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
-
Y
-
Y
---------
S
QNKFT
P
E
Q
C
E
N
G
VWQV
I
G
F
K
E
F
L
P
W
L
T
--
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
------
I
P
D
-------
I
K
G
D
I
Y
L
L
D
---
A
T
--
D
L
S
Q
W
D
T
N
A
S
Q
R
A
-----------------------------------------------------------------------------------