@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1324: (2015-12-07 )
MAIKGITLKESMNRSVQAIMPLDEEKEVFNQKLVSYLTHLKDKEDESEEYQKNLLKVFLESVLPYNFINTSSRIDLAIYNGKDANSSLGILFECKSLFNKSEMMSTEKINSKAFQEIVYYYLQERLFNKNLEIKKCIITNGLSWFVIEAKEFEKHFFKNKKLVDLVTKFRNNQLSSNKTDFLYSEVIAPEIDKAFEKGIVIAHFDLSQALVKTSKSIEIKKNNLTQLYRFFTAENLLNKEIFTDSNKLNKNFYDELLYLMGLEETKSGTSKIISRLKPIKRQRYSFVENIINKLEMKDVSKEKQEDIAIQLTVVWTNRILFLKLLESQLVLFNKDESYRFLTYEKLPNFEEIYGLFFAVLAKKVSERNDRVQEKFGYVPYLNSSLFEETEIEISRDGIGIDRLPEGDIEIFSKTALKGVDKKRKKGNINFIEYLFEFLDSYDFSTSISHHEKSKNDLINASVLGLIFEKINGYRDGSFYTPGNITMYMSRKAIRTAAVDKVNELLGWNCETVEEIKFAIGHSVENARKVSQAIDDLKVCDPAVGSGHFLVSILNEIIALKSDLNILFDADGNYIGNLIQCYVINDELVIQDMSGNNFLYQTGNQQSEQIQKAIFNQKRHILENSLFAVDINPSSVNICRLRLWIELLKSSYYYQDTDTNQPVLTTLPNIDINIKVGDSLLHKFEFDYEFDMRKTDFKDYLSLVKDYKETNNKRVKAEIWEKIERLKHSFDDTASSPELKKLSRLISERNKAGAISLFEDENKNSKEVAELNKQLAKAEKELEYRLKNPLFAKGMEWRMEFPEILGEAGEFIGFDLVIGNPPYIFARNQSFTDEMKSYYSRTYQVSEYQANTYTIFMELAYQLLRKGGTFSYIIPNNFLTIQTNSRVRQFITEQTSDVVLINSLDKIFADASVDNCIIFFKKNAPNWIEVAELYHGEFNTVGRVAPDFFGEIPTFSISMVKYRQAIDIFWKVNHFPILGRPEISTVKSGIKAYETGKGNPKMTAQDKNNRIYHARERSDDSYRPYLDGENVSRYKLTWNGEYVKYGENLAAPRDKEIFEKPRILVRQIPSKSTYAVEAVYTDSDVINDLNSMVITDIQVNPFYLLGILNSRLISLWFFMKFDKFQRRLFPQFKVNELGDFPIPDATDSQQEDIAQVVEQLMEEMKKDSPDTEKVNQLNLEIDELVMDLFDLAEEEKQTVRDFEV
Atome Classification :
(20 SA)
--.........10........20........30........40...-.....50........60------------.........70........80........90........100.....---------------....110......-----------.120.......130-----.........140.......150.......160.......170.......180.......190.......200.......210.......--------220.......230....--...240-------------........250.......260.-------......270.......280.......290....-----...300.......310........320---------........------------------330....--...340.......350..---------.....360.......370.......380.......390.....-----....400.-...-...410------------......--..420....----...430.......440........450.......460.----......------470..------.....480...------------....490.......500....------...510.......520.......530.......---540.......550-.......560.........570.......580.......590.......600----.........610..---------------.....620..------......630-...-......640..-----......650....-.--...660-------.......-.670.........680..---------.....690.......700----..-......710-........720.-......730.--.-.....740.......750.......760....-...770.....---..---------780........790----..-----.....---------.800.---------....-..810-.......820.......-----830.-----......840-------------------...---.--.-...-.850....-...860..-------.-------....870.......880.-.....-.-..890........900.-......-910.-------------.......920---------....--.---....930-....--...--.940..---.----------.--.-..950----....-..---..960..-------.....970-------.-........-980.......----------990....----..-.1000......1010......1020-------...-------..-.1030....-------------------.--.1040-....-..-----------------------------------------1050...-----....1060.....-..-1070..--....----------------------------------------------------1080......1090-.--.....1100.......1110......-1120-.......------..1130......1140----.....-..---.1150......1160--.........1170---......1180........1190...-...1200-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MAIK
G
I
T
L
K
E
S
MNR
S
V
Q
A
IMPLD
E
E
K
E
V
F
N
Q
K
L
V
S
Y
L
T
HLKDKE-D
E
S
E
E
Y
Q
K
N
L
L
K
V
F
L
E
-------------SVLPYNFINTS
S
R
I
D
L
A
I
YNGKDANSS
L
G
I
L
F
E
C
K
S
L
F
N
K
--
S
E
MM
S
---------------
T
EKI
N
S
K
A
F
Q
E
I
V
-----------
Y
Y
Y
L
Q
E
R
L
FNKN-------L
E
I
K
K
C
I
ITNG
L
S
W
F
V
I
E
A
K
E
F
E
K
H
F
FKN
K
K
L
V
D
L
V
T
K
F
RNNQLSSNK
T
D
F
L
Y
S
E
VIA
P
E
I
D
K
A
F
EK
G
I
V
I
A
HF
D
L
S
Q
A
L
V
KTSK
S
I
E
I
--------KKN
N
L
T
Q
L
Y
R
F
F
T
A
E
N
L
--
L
N
K
E
I--------------FTDSNKL
N
K
N
F
Y
D
E
L
L
Y
L
MG
L
E
-------ETKS
G
T
S
K
I
I
S
R
L
K
P
I
K
R
Q
R
Y
S
F
V
E
N
I
I
N
K
L
E
M
-----
K
D
V
S
K
E
KQE
D
I
A
I
Q
-
L
T
V
V
WTN
R
I
L
F
----------
L
K
L
L
E
S
Q
L
------------------
V
L
FNKDE--
S
Y
R
F
L
T
Y
E
KLP
N
F
E
E
I
Y
G
---------
L
F
F
A
V
L
A
K
K
V
S
E
R
N
D
R
V
Q
E
K
FGYVPYL
N
S
S
LFEET
E
--
I
E
I
SR-----DGIGIDRL-PEG-
D
I
E
I
F
-------------
S
K
T
A
LK--GVDKKRKKG----NI
N
F
I
E
Y
L
F
E
F
L
D
SY-DFSTSISHHEKSKNDL
I
N
A
S
V
L
----
G
L
I
F
E
K
------INGYR------DG
S
F
YTPG
N
I
T
------------
M
Y
M
S
R
K
A
I
R
T
A
A
V
D
K
V
N
E
L
LG------WNC
E
T
V
E
E
I
K
F
A
IGHS
V
E
N
A
R
K
V
S
Q
A
I
D
D
L
KVC---DPAVGS
G
H
F
L
V
S
I
-
L
N
E
I
I
A
L
K--SD
L
N
I
L
F
DADG
N
Y
I
G
N
L
I
Q
C
Y
V
IND
E
L
V
I
Q
DMSGN
N
F
L
Y
Q------TGN
Q
Q
S
E
Q
I
Q
K
A
I
F
---------------
N
Q
K
R
H
I
L-EN------
S
L
F
A
V
DI---NPS-SV
N
I
C
R
L
R
-
L
W
-----
I
E
L
L
K
SS
Y
-
Y
YQD-T--DTNQ
P
--------
V
L
T
TLPN-
I
D
--
I
N
I
K
V
G
D
S
L
L
H
K
FE---------F
D
Y
E
FDMRKT
D
F
K
D
Y
L
S
-----
L
V
-
K
D
Y
K
E
TNN--KR
V
K
A
E
I
W
E
K
I
E
-
R
L
K
H
SFDDTA--S-
S
P
E
L
K
K
L
S
R
L
I
S
ERNKAG
A
I
S
L
FEDENK
N
S
K
E
-
V
A
E
L
N
K
Q
L
A
K
A
---
E
K
---------
E
L
-
E
Y
R
LKNP
L
F
A-----K
G
-----
M
E
W
R
M
---------
E
F
P
E
I
---------LGEA-GE
F
I
G
-
F
D
L
V
IGNP
P
Y
I
F
ARNQ
S
-----
F
T
D
E
-----
M
K
S
Y
Y
SR---------------------
T
Y
Q
---
V
--
S
-
E
YQ-A
N
T
Y
T
I
F
M
-
E
L
A
Y
Q
L
L
R-------K-------GG
T
F
S
Y
I
IPN
N
F
L
T
I
--Q-T
N
S
R
V
-
R
-
Q
F
I
T
-EQTS
D
V
V
L
I
N
S
L
-
D
K
I
F
AD-AS-V-------------D
N
C
I
I
F
F
K-----------KNAP--
N
---
W
I
E
V
A
E
--
L
YHG--EFN--TVGRV
A
---
P
----------
D
--
F
-FGEI-----P
T
F
S
-
I
S
---
M
V
K
Y
R
Q
A
-------
I
D
I
F
W
K---------V-N
H
F
PILGR-P
E
I
S
T
V
K
S
G
I
----------
K
A
YETGK----GN-P
K
M
T
AQDKNN
R
I
Y
H
A
RERSDDSYRP-------YLD-------GE-NV
S
R
Y
K
L
T
W-------------------N--GE
Y
V
K-YGEN-LA-----------------------------------------AP-R
D
K
E
-----
I
F
E
K
P
R
-
I
L
V
R
QI-PS-KS
T
Y
A
V
--
E
A
V
Y----------------------------------------------------T
D
S
D
V
I
N
D
L
N
S
M
V
I
-
T
--
D
I
QVNP-
F
Y
L
L
G
I
L
N
S
R
L
I
S
L
W
F
F
M
K
-
F
----
D
K
F
Q
R
R
L------FPQFKVNELGDFPI------PDATD-
S
Q
---
Q
E
D
I
A
Q
V
V
E
Q
L
M
-----
E
E
M
KKDSPD
T
E
K
V
---
N
Q
LNL
E
I
D
--
E
L
V
M
D
L
F
D
L
A
E
E
E
K
Q
-
T
V
RDFEV-------------------------------------
51
Fugue
71.08
18%
-22
- C3 -
5AMR
-
?
A:
[1-1746]
GM
D
Y
Q
E
Y
Q
Q
F
L
A
R
I
N
T
A
R
D
A
C
V
A
K
D
I
D
V
D
L
L
M
A
R
H
D
Y
F
G
R
E
L
C
K
S
L
-
N
I
E
Y
R
N
D
V
P
F
I
D
I
I
L
D
IRPEVDPLTIDAP
H
I
T
P
D
N
Y
L
Y
I
N
N
V
L
Y
I
I
D
Y
K
V
S
V
S
N
E
S
S
V
I
T
Y
D
K
Y
Y
E
L
T
R
D
I
S
D
R
L
S
I
P
I
E
I
V
I
I
R
I
DPVSR
D
L
H
I
N
S
D
R
F
K
E
L
Y
P
T
I
V
V
DINF
N
Q
F
F
D
L
K
Q
L
L
Y
E
K
F
G
DD
E
E
F
L
L
K
V
A
H
G
D
F
T
L
T
A
P
W
C
K
T
G
C
P
E
F
W
K
H
P
I
Y
K
E
F
K
M
S
M
P
V
P
E
R
R
L
F
E
E
S
V
K
F
N
A
Y
E
S
E
R
W
N
T
N
L
V
K
I
R
E
Y
----
T
K
K
D
Y
S
E
H
I
S
K
S
A
K
N
I
F
L
ASGFYKQP
N
K
N
E
I
S
E
G
W
T
L
M
V
E
R
V
Q
--
D
Q
R
E
I
S
KSLHDQKPSIH
F
I
W
G
A
H
N
P
G
N
S
N
N
A
T
F
K
L
I
L
L
S
K
S
L
Q
S
IKGI
S
T
Y
T
E
A
F
K
S
L
G
K
M
M
D
I
G
D
K
A
I
E
Y
E
E
F
C
M
S
L
K
S
K
A
R
S
S
W
K
Q
I
M
N
K
K
L
E
P
K
Q
I
N
N
A
L
V
L
W
E
Q
Q
F
M
I
NNDLID
K
S
E
K
L
K
L
F
K
N
F
C
GIGKKQFKNKMLEDS
K
P
K
I
L
D
F
D
D
A
--
N
M
Y
L
A
S
L
T
M
M
E
Q
S
K
K
I
L
S
KSNGLKPDN
F
I
L
N
E
F
G
S
R
I
K
D
A
N
K
E
T
Y
D
N
M
--
H
K
I
F
E
T
G
Y
W
Q
C
I
S
D
F
S
T
L
M
K
-----
N
I
L
S
V
S
Q
Y
N
R
H
N
-
T
F
R
I
A
M
C
ANNN
V
F
A
I
V
F
P
S
A
T
V
V
Y
--
S
I
I
V
L
H
K
E
E
ENIF
N
P
G
C
L
H
G
T
F
K
C
M
N
G
Y
I
S
I
S
R
A
I
R
L
D
K
E
R
C
Q
R
I
V
S
S
P
G
L
F
L
T
T
C
L
L
F
K
H
DNPTLV
M
S
D
I
M
------
N
F
S
I
Y
T
S
L
S
I
T
K
S
V
L
S
L
TEP
A
R
Y
M
I
M
N
S
L
A
I
S
S
N
V
K
D
Y
I
A
E
K
F
S
PYTKT
L
F
S
V
Y
M
T
R
L
I
K
N
A
C
F
D
A
Y
D
Q
R
Q
R
V
Q
L
R
D
I
D
Y
D
I
T
---
Q
K
G
I
K
D
N
R
E
L
T
S
I
W
F
P
G
S
V
T
L
K
--
E
Y
L
T
Q
I
Y
L
P
F
Y
F
N
A
K
G
L
H
E
K
H
H
V
M
V
D
L
A
K
T
I
L
E
I
E
C
E
Q
R
E
NIKEIW
S
T
N
C
T
K
Q
T
V
N
L
K
I
L
I
H
S
L
C
K
N
L
L
A
D
T
S
R
H
N
H
L
R
N
R
I
-
E
N
R
N
NFRR
S
I
T
T
I
S
T
FTS
S
K
S
-
C
L
K
I
G
D
F
R
-
K
E
-----
K
E
L
Q
S
V
K
Q
-
K
K
I
L
-
E
--
V
Q
S
R
K
MRLAN
Y
E
M
L
R
N
A
M
P
N
-
Y
T
D
Y
I
S
T
K
V
F
D
R
L
Y
E
L
L
D
K
KVLTDKP
V
I
E
Q
I
M
D
M
M
I
D
H
K
K
F
Y
F
T
F
F
NEI
F
V
-
G
E
Y
E
A
K
M
C
--
M
Y
A
V
E
R
I
A
K
--
E
-
R
C
K
L
N
P
D
E
M
I
--
S
-
E
P
G
D
G
K
L
K
V
L
E
Q
K
S
E
Q
E
I
R
F
L
V
E
T
T
R
Q
K
N
R
E
I
-
D
E
A
I
E
A
L
L
G
K
I
---
E
K
L
S
L
G
K
A
K
G
L
K
M
-
E
I
N
A
D
M
S
K
W
S
-----
A
Q
DVFYK
Y
F
W
L
I
A
L
DPILY
P
Q
E
K
E
R
I
---------
L
Y
F
M
-
C
N
Y
M
D
-
K
E
L
I
L
-
P
D
E
L
L
F
N
L
L
D
Q
-----
K
V
A
Y
-----
Q
N
D
I
I
A
T
M
T
N
QLNSN
T
V
L
I
K
RNWLQGNF
N
Y
T
---
S
--
S
-
Y
V
H
-
S
C
A
M
S
V
Y
K
-
E
I
L
K
E
A
I
T
-------
L
-------
L
D
--
G
S
I
L
V
N
S
L
V
H
S
--
D
-
D
N
Q
T
S
-
I
-
T
I
V
Q
-
D
K
M
E
N
D
K
I
I
D
F
A
-
M
K
E
F
E
R
-
A
C
-
L
T
F
G
C
Q
A
N
MKK
T
Y
V
T
N
C
I
K
E
F
V
S
L
F
N
L
YG
E
P
F
S
I
Y
G
R
--
F
---
L
L
T
S
V
G
DC
A
Y
I
G
--
P
Y
E
--
D
L
A
S
R
I
---
S
----------
S
--
A
-
Q
T
A
I
K
H
GCP
P
S
L
A
W
V
S
---
I
A
I
S
H
W
M
-------
T
S
L
T
Y
N
MLPGQSNDP
I
-
D
Y
F
P
A
E
N
R
-
K
D
I
P
I
E
L
N
G
V
L
D
A
P
L
S
M
I
S
T
V
G
L
E
S
G
N
----
L
Y
-
F
L
I
K
L
L
S
K
Y
T
P
V
M
Q
K
R
E
S
V
V
N
Q
I
A
E
-------
V
K
N
WKVEDLT
D
N
-
E
I
F
R
L
K
I
L
R
YLVLDSIL
T
P
R
K
FTGSLRK
L
--
Y
S
F
S
K
-
Y
Q
D
R
-
L
S
-----------------------------------------
S
P
-
G
G
M
V
E
L
F
T
Y
L
L
E
K
P
E
-
L
L
V
T
K
G
-
E
D
-
M
K
D
Y
M
E
--
S
V
I
F
R
Y
N
S
K
R
F
K
E
S
L
S
I
Q
N
P
A
Q
L
F
I
E
Q
I
L
F
S
HKPVID
F
S
G
I
R
D
K
Y
INILGKVT
F
T
E
A
Y
R
L
L
M
R
D
L
S
S
L
E
L
-
T
--
N
D
D
I
Q
V
-
I
Y
S
Y
I
I
L
N
D
P
M
M
I
T
I
A
N
T
H
-
I
L
S
I
Y
G
S
P
Q
R
R
M
G
M
S
C
S
T
M
P
E
F
R
N
H
H
S
P
A
L
V
L
R
A
Y
SNN
P
D
I
P
T
-
E
M
---
A
R
D
L
V
H
L
K
E
F
V
E
N
T
NL
E
E
K
M
K
V
R
I
A
M
N
E
A
E
K
GQ
R
D
I
V
F
E
L
K
--
E
M
T
R
F
Y
Q
V
C
Y
E
Y
V
K
S
-
T
E
H
K
I
K
V
F
I
L
PAKSYT
T
T
D
F
C
S
L
M
Q
G
N
L
IKDK
E
W
Y
T
V
H
Y
LKQIL
52
Fugue
63.63
18%
-19
- C2 -
4NUZ
1
?
A:
[1-892]
------------------
M
K
I
P
E
K
I
P
M
K
P
L
H
G
P
L
Y
G
G
Y
F
R
T
W
H
D
K
T
S
D
P
T
E
K
D
K
V
N
S
M
G
E
L
-------------------------
P
K
E
V
D
L
A
F
I
F
-------------------------
H
D
---------------
W
T
K
D
Y
S
L
F
W
K
E
L
A
-----------
T
K
H
V
-
P
K
L
N
K
Q
G
-------
T
R
V
I
R
T
I
P
-----
W
R
F
L
A
G
G
D
-------
N
S
G
I
A
E
D
T
S
K
Y
P
N
T
----------------
P
E
G
N
K
A
L
A
K
A
I
V
D
E
Y
---------------
V
--------
Y
K
Y
N
L
D
G
L
D
V
Q
V
E
H
D
S
I
P
K
V
D
K
K
E
--------------
D
T
A
G
V
E
R
S
I
Q
V
F
E
E
I
G
K
L
I
G
-----------
P
K
G
V
D
K
--------------------
S
R
L
F
I
-----
M
D
S
T
Y
M
A
D
K
N
P
L
I
E
-
R
G
A
P
Y
I
N
L
L
L
V
----------
Q
-------------------------
V
Y
G
S
Q
G
E
KG
G
W
E
P
V
S
N
R
P
E
K
T
M
E
E
R
W
Q
---------
G
Y
--------
S
K
Y
I
R
P
E
Q
Y
M
I
G
F
S
F
Y
E
E
N
A
Q
E
G
N
L
W
--
Y
D
I
N
S
RKDED
K
A
N
G
I
N
T
D
-
I
T
G
T
R
A
E
R
Y
-------------
A
R
W
Q
P
K
TG
G
V
-----
K
G
----
G
I
F
S
Y
A
-----
I
D
R
D
-
G
V
A
H
Q
P
K
K
Y
A
K
----------------------------
K
D
A
T
------
D
N
I
F
H
S
D
Y
S
V
S
------------
K
A
L
K
T
V
M
L
K
D
K
S
Y
D
L
I
D
E
K
D
F
------
P
D
K
A
L
R
E
A
V
M
A
Q
V
G
T
R
K
G
D
L
E
R
F
N
---
G
T
L
R
L
D
---
N
P
A
I
Q
S
----
L
E
G
-
L
N
K
F
K
K
L
---
A
Q
L
D
L
I
---------
G
L
S
R
I
T
K
L
D
R
S
V
L
P
A
N
M
K
P
G
K
D
T
L
E
------
T
V
L
E
T
Y
K
K
-----------------------------
D
N
------
K
E
E
P
A
T
I
---
P
P
V
-
S
L
K
V
S
G
L
T
-
G
L
-----
K
E
L
D
L
S
G
F
-
D
R
E
T
L
A
--
G
L
D
A
A
--------
T
L
T
S
L
E
K
-
V
D
--
I
S
---
G
N
K
L
-------------------
D
L
--------------------
A
P
G
T
E
N
--
R
Q
I
F
D
T
M
L
S
T
I
S
-
N
H
V
G
S
N
E
Q
T
V
--
K
-
F
D
K
Q
K
P
T
G
H
Y
P
D
T
Y
G
K
T
------------------
S
L
R
L
P
V
A
N
E
---
K
V
---------
D
L
-
Q
S
Q
L
---------------------------------
L
F
G
T
---------
V
T
N
Q
-
G
T
L
I
--------
N
S
E
A
D
Y
K
A
Y
Q
N
-----
H
K
I
A
-----
G
R
S
F
V
D
S
---------------------
N
Y
H
---
Y
--
N
-
N
F
K
-
V
S
----------
Y
E
--------------------
N
Y
T
V
K
V
T
D
S
T
L
G
---
T
-
T
T
D
K
T
-
L
-
A
T
D
K
-
E
E
T
Y
K
V
D
F
F
S
P
A
-
D
K
---
T
-
K
A
-
V
-------------
H
T
A
K
V
I
V
G
-----------
D
E
K
T
--
M
---
M
V
N
L
A
E
--
G
A
---------
T
V
I
G
G
S
---
A
----------
D
--
P
-
V
N
A
R
-----
K
V
F
D
-
G
Q
---
L
G
S
E
T
D
N
-------
I
S
L
G
W
D
---------
S
-
K
Q
S
I
I
F
K
L
-
K
E
-----------------------------------
D
G
L
I
K
H
W
R
F
F
N
D
S
A
R
N
P
E
T
T
N
K
-------
P
I
Q
-------
E
A
-
S
L
Q
I
F
-----------------------------------
N
-
I
K
-----------------------------------------
D
Y
-
N
L
D
N
-----
L
L
E
N
P
N
-----
K
F
-
D
D
-
E
K
Y
W
I
T
--
V
D
T
Y
----------------------------------------------------
S
A
Q
G
E
R
A
T
A
F
S
N
T
L
-
N
--
N
I
------------
T
S
K
Y
W
R
V
V
F
D
T
K
-
G
----
D
R
Y
S
S
P
V
------
V
P
E
L
Q
I
--
L
G
-
Y
P
L
------
P
N
A
D
T
I
M
K
---
T
V
T
T
A
K
E
L
S
Q
Q
K
-----
D
K
F
S
Q
K
M
L
D
E
L
K
I
---
K
E
M
A
L
E
T
S
L
N
S
K
I
F
D
V
T
A
I
N
A
N
A
G
V
-
L
K
D
C
I
E
K
-------------------------------------
48
Fugue
57.78
15%
-19
- C3 -
2ADM
1
MTTA_THEAQ
A:
[21-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
E
T
P
P
E
V
V
D
F
M
V
S
L
A
E
A
P
R
G
G
R
V
L
E
P
A
C
A
H
G
P
F
-
L
R
A
F
R
E
A
H
G
T
G
---
Y
R
---------
F
V
-
G
V
E
I
D
P
K
A
L
D
-----
L
P
-----
P
W
A
E
G
---------
I
L
A
D
F
---------
L
L
W
E
-
P
G
E
-
A
-
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
-----
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
--
K
T
S
V
Y
Y
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
G
L
S
---
L
W
D
T
Q
E
--
S
E
S
G
--
F
T
P
--
I
L
W
A
E
Y
---
P
----------
H
--
W
-
E
G
E
I
-----
I
R
F
E
-
T
E
---
E
T
R
K
L
E
I
-------
S
G
M
P
--------------------
L
-
G
D
L
F
H
I
R
F
A
A
----------
R
S
P
E
F
K
K
----
H
P
-
A
V
-------------
R
K
E
P
G
P
G
L
V
P
-------
V
L
T
-------
G
R
-
N
L
K
P
G
W
V
D
Y
-------------------
E
--
K
N
H
S
G
L
W
M
P
K
-
E
R
-----------------------------------------
A
K
-
E
L
R
D
-----
F
Y
A
T
P
H
-
L
V
V
A
H
T
-
K
G
----
T
R
V
--
V
A
A
W
----------------------------------------------------
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
-
S
T
L
V
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
-
Y
--------
R
D
F
------
V
P
H
L
T
L
R
M
L
E
R
L
P
V
------
R
R
E
Y
G
-
F
H
---
T
------------------------------------------------------------------------------------------------------
49
Fugue
56.13
16%
-18
- C3 -
3UFB
-
?
A:
[12-495]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
P
M
T
T
A
Q
Q
L
G
A
I
V
K
S
S
R
Q
I
M
R
K
D
K
G
L
N
G
D
L
D
R
L
P
M
-
L
T
W
I
M
F
L
K
F
L
D
D
L
E
Q
M
R
E
T
E
A
V
L
E
G
K
S
F
Q
-
P
A
I
E
A
P
Y
R
W
R
D
W
A
A
I
E
-
G
G
I
------
T
G
D
E
L
I
A
F
I
N
N
D
E
A
---------------
M
R
P
D
G
T
R
-
G
I
------
G
L
F
A
Y
L
R
---
S
L
Q
G
D
N
G
G
D
R
R
D
-
V
I
-----
A
T
V
F
K
G
M
Q
N
R
M
I
N
-
G
--
Y
L
L
R
D
--------
V
V
D
K
I
N
G
-
I
H
--
F
N
---
S
S
E
E
M
H
T
L
S
---------
R
L
Y
E
T
M
L
R
E
M
R
D
A
A
-----------
G
D
S
G
E
F
Y
T
--
P
R
P
V
V
R
F
M
--
V
E
-
V
M
D
P
Q
L
G
E
S
V
--
L
-
D
P
A
C
G
------
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
C
K
T
V
E
D
-
R
E
V
L
Q
E
S
S
I
F
G
G
E
A
K
S
---------
L
P
-
Y
L
L
V
Q
M
N
L
L
L
-----
H
G
-----
L
E
-------------
Y
P
R
I
DPENSLRFP
L
R
E
M
-
G
D
K
D
R
-
V
D
V
I
L
T
N
P
P
F
----
G
G
E
-----
E
E
K
G
-----
I
L
G
N
F
P
E
---------------------
D
M
Q
---
T
--
A
-
E
-----
T
A
M
L
F
L
-
Q
L
I
M
R
K
L
K
-------
R
PGHGSDN
G
G
R
A
A
V
V
V
P
N
G
T
L
F
S
--
D
G
I
S
A
R
I
-
K
-
E
E
L
L
-
K
N
F
N
L
H
T
I
V
R
L
P
-
E
G
V
F
A
P
-
Y
T
D
I
-------------
A
G
N
L
L
F
F
D
-----------
R
S
G
P
--
T
D
D
I
W
Y
Y
Q
I
T
--
V
P
E
G
RK
K
Y
T
--
K
T
K
P
M
E
---
S
----------
H
--
E
-
F
D
E
C
-----
L
N
W
W
--------
S
N
R
I
V
-------
N
Q
N
A
W
K
---------
E
-
S
A
S
E
I
I
K
Y
-----
S
E
S
G
Q
L
----------
I
D
V
N
L
D
R
----
K
N
-
P
N
S
L
E
V
L
E
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
55.69
20%
-68
- C3 -
3UFB
-
?
A:
[156-416]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
D
V
V
D
K
I
N
G
I
-
H
F
N
S
S
-----------
E
E
M
H
T
L
----
S
R
L
Y
E
T
------
M
L
R
E
M
R
D
AAGD
S
G
E
F
Y
T
P
R
P
V
V
------------
R
F
M
V
E
V
M
D
-
P
-------------------------------------------
Q
L
G
E
S
V
L
---
D
P
A
C
G
T
G
G
F
L
V
E
A
-
F
E
H
L
E
R
Q
C
--
K
T
V
------------------------------------------------------------------------
E
D
R
E
V
L
Q
-
E
S
------
S
I
F
G
G
E
A
---
K
S
L
-
P
Y
L
L
V
Q
M
N
-
L
L
-----
L
H
G
L
E
Y
------------------------------------
P
R
I
D
P
E
N
S
L
R
F
P
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
--------------
G
D
K
D
R
-
V
D
V
I
L
T
N
P
P
F
G
G
E
E
E
K
G
-----
I
--------
L
-----
G
---------------------
N
F
P
---
E
--
D
-
M
Q
T
-
A
E
T
A
M
L
F
L
-
Q
L
I
M
R
K
L
K
RPGHGSD
N
-------
G
G
R
A
A
V
V
V
P
N
G
T
L
F
S
--
D
G
I
S
A
R
I
-
K
-
E
E
L
L
-
K
N
F
N
L
H
T
I
V
R
L
P
-
E
G
V
F
A
P
Y
T
D
-
I
-------------
A
G
N
L
L
F
F
D
-----------
R
S
G
P
--
T
---
D
D
I
W
Y
Y
--
Q
I
T
V
--
P
E
G
--
R
K
K
Y
T
K
---
T
----------
K
--
P
-
M
E
S
H
-----
E
F
D
E
-
C
L
---
N
W
W
S
N
R
I
-------
V
N
Q
N
A
W
---------
K
-
E
S
A
S
E
I
I
K
-
Y
S
E
S
G
Q
L
I
D
V
----------
N
L
D
R
K
N
P
----
N
S
-
L
E
V
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
55.04
11%
-18
- C1 -
3S1S
26
?
A:
[6-875]
------------------------------
L
N
N
C
V
F
S
Y
L
P
S
Y
G
D
D
-------------------------------------------------------------------------------------------------
E
V
S
V
Y
H
P
I
C
-----------
E
A
A
L
N
Q
A
L
V
N
T
G
-------
L
D
S
T
-
Y
E
V
V
H
H
E
L
V
G
S
I
E
A
D
F
V
I
K
N
K
Q
T
K
K
Y
L
L
I
V
E
V
K
R
T
K
S
Q
V
S
S
T
R
Y
R
L
Q
A
Q
S
Y
V
R
E
A
N
I
K
V
E
Q
H
Y
Y
C
L
T
N
L
E
--------------------------
I
I
D
F
F
K
H
D
P
N
K
P
V
--
V
S
Q
Q
I
--------------
I
E
P
S
P
I
V
V
G
N
F
S
D
T
--
V
S
E
F
Y
N
-------
R
L
V
E
A
F
Q
N
I
I
D
I
S
V
N
D
A
G
T
Y
K
S
S
T
A
N
L
V
D
I
L
E
N
-----
R
K
D
N
S
T
S
W
H
Q
A
L
V
V
-
A
G
Y
E
Y
I
R
G
V
L
R
----------
G
Q
N
V
E
V
P
T
------------------
R
D
----------------------------------------
A
I
Y
F
K
S
R
P
G
R
L
L
E
E
G
R
K
I
-
D
F
N
V
L
F
--------------------------------------------------
S
E
P
E
--
P
N
T
N
D
N
D
I
W
----
N
V
N
L
L
S
S
L
N
D
L
G
R
R
I
-
L
T
G
------------
D
E
L
A
E
L
I
----
H
D
I
A
T
R
-------
G
R
G
H
------
E
G
V
V
P
T
D
I
E
L
G
------------
K
V
L
S
I
I
S
Q
H
I
L
G
--------------------------------------
R
P
L
T
E
D
E
V
I
S
---
D
P
A
A
G
S
G
N
L
L
A
T
V
-
S
A
G
F
-------------------------------------------------------------------------------------
N
N
V
M
P
R
------
Q
I
W
A
N
D
I
---
E
T
L
-
F
L
E
L
L
S
I
R
-
L
G
-----
L
L
F
P
Q
L
----------------------------
V
S
S
-
N
N
--
A
P
T
I
T
G
E
D
V
C
S
L
N
P
---------
E
D
F
A
N
-------------------------------------------------
V
S
V
V
--
V
M
N
P
P
Y
V
S
G
V
T
D
P
A
I
K
R
K
F
A
H
K
I
I
Q
L
T
G
N
R
P
Q
T
L
-
F
G
Q
I
G
V
E
A
L
F
L
---
E
L
---------
V
T
-
E
L
V
Q
D
G
T
V
I
S
A
I
M
P
K
Q
Y
-----
L
T
A
Q
G
---------
N
E
S
K
A
---------
F
R
E
F
L
V
G
N
F
G
-
L
E
H
I
F
L
Y
P
R
E
G
L
F
E
E
V
I
-----
K
-------------
D
T
---------------------
V
V
F
---
V
--
G
-
R
K
G
-
S
S
V
E
E
I
E
V
-
L
D
S
F
T
P
L
E
-------
Q
-------
V
D
L
H
N
L
K
R
A
L
S
N
S
S
N
--
E
-
Q
I
I
Q
P
M
G
M
E
L
R
K
-
E
K
R
E
E
L
E
N
R
V
T
V
-
G
W
R
H
I
T
-
S
N
-
G
-------------
R
V
A
E
E
W
I
T
-----------
N
N
L
E
--
S
---
H
C
I
R
L
V
--
A
S
D
Y
--
D
L
R
--
R
G
---------------------
R
-
V
G
N
K
-----
G
A
S
D
-
L
L
---
F
I
N
S
K
K
K
-------
L
W
D
L
L
D
---------
E
-
S
V
P
R
D
W
L
Y
-
P
A
L
R
K
V
N
E
-
I
----------
N
T
P
I
F
N
E
----
D
A
-
T
P
V
R
F
L
C
P
P
N
S
A
Y
Q
D
G
T
G
E
S
I
I
L
D
K
-------
I
L
D
-------
V
Y
-
V
D
F
Q
V
Y
K
S
K
-------------------
Q
--
K
K
F
E
K
-
S
K
E
E
-
L
K
-----------------------------------------
E
I
-
L
Y
K
E
-----
S
D
F
Y
S
S
-
E
H
T
V
F
I
-
P
R
-
A
L
R
R
S
A
--
R
A
F
I
----------------------------------------------------
N
E
Q
K
V
F
C
S
T
N
A
L
E
V
-
F
--
G
G
N
S
E
E
M
W
L
L
L
S
W
L
S
S
-
V
F
A
Q
L
Q
F
E
A
M
A
----
K
D
Q
E
G
E
R
------
K
----------
L
E
K
------
K
S
I
Q
N
-
L
Y
---
I
P
N
L
G
D
I
D
D
V
L
K
-----
Q
D
L
I
E
E
V
R
E
I
H
F
F
---
D
L
C
R
P
R
V
R
--
K
L
D
L
L
W
A
K
V
F
W
S
G
N
E
M
S
K
T
K
E
A
A
E
L
L
E
D
L
V
F
E
R
YPEGSQ---------------------
22
HHSearch
52.76
16%
-28
- C3 -
2IH2
5
MTTA_THEAQ
A:
[97-413]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
-----
K
Y
P
I
H
V
F
K
A
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
-
S
V
Y
Y
L
G
--
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
--
W
--
D
T
Q
E
--
S
E
S
--
G
F
T
P
I
------------------
L
-
W
A
E
Y
----------
P
H
---
W
E
G
E
I
I
R
FE-----
T
E
E
T
-
R
---------
K
-
L
E
I
S
G
M
P
L
-
G
D
L
F
H
I
R
F
A
A
----------
R
---
S
P
E
----
F
----
K
K
H
P
A
-------
V
R
K
E
P
G
P
G
L
V
P
-------
V
L
T
-------
G
R
-
N
L
K
P
G
W
V
D
Y
-------------------
E
--
K
N
H
S
G
-
L
W
M
P
K
E
R
-----------------------------------------
A
K
-
E
L
R
D
-----
F
Y
A
T
P
H
-
L
V
V
A
H
T
K
G
T
-
R
V
V
A
A
W
D-
E
R
A
Y
----------------------------------------------------
P
W
R
E
E
F
------
H
L
L
P
K
E
G
V
R
L
D
P
-
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
-
Y
----
R
----
D
F
------
V
P
H
L
T
L
R
M
L
E
R
L
P
V
------
R
R
E
Y
G
-
F
H
---
T
------------------------------------------------------------------------------------------------------
21
HHSearch
51.20
14%
-37
- C3 -
3S1S
12
?
A:
[398-853]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
-
V
S
V
V
V
M
N
P
P
Y
V
S
G
V
T
D
P
-----
A
I
K
-------
R
K
F
A
H
K
---------------------
I
I
Q
L
TG
N
RP
Q
T
L
F
G
Q
I
G
V
E
A
L
F
L
-
E
L
V
T
E
L
V
Q
-------
D
-------
G
T
V
I
S
A
I
M
P
K
Q
Y
L
T
A
QG
N
-
E
S
K
A
F
-
R
-
E
F
L
V
-
G
N
F
G
L
E
H
I
F
L
Y
P
R
E
G
L
F
E
E
-
V
I
-
K
-------------
D
T
V
V
F
V
G
R
-----------
K
G
S
S
--
V
---
E
E
-
I
E
V
--
L
D
S
F
T-
P
L
E
QV
D
L
H
N
L
K
R
A
L
S
N
SSNE
Q
I
I
Q
P
M
G
M
E
-
L
R
K
E
-----
K
R
E
E
-
L
E
N
R
V
T
V
G
W
R
H
I
TS
N
G
R
V
A
E
E
W
I
-
T
---------
N
N
L
E
S
H
C
I
R
L
V
A
S
D
Y
D
L
R
R
G
R
----------
V
-
G
N
K
G
A
S
D
L
L
F
I
N
S
K
K
K
L
W
-----
D
L
L
D
E
S
V
P
R
D
W
L
Y
P
-------
A
L
R
-------
K
V
N
E
I
N
T
P
I
F
N
E
-------------------
D
AT
P
V
R
F
L
-
C
P
P
N
-
S
A
YQDGT
G
E
S
I
I
L
D
K
I
L
D
V
Y
V
D
F
Q
V
Y
K
SKQKKFEKS
K
E
E
L
K
E
I
L
Y
-
K
E
S
D
-----
F
Y
S
S
E
H
T
V
F
I
P
R
A
-
L
R
R
S
A
R
A
F
I
N
E
Q
K
V
F
----------------------------------------------------
C
S
T
N
A
L
------
E
V
F
G
--
G
N
S
E
E
M
-
W
L
L
L
S
W
L
S
S
V
F
A
Q
L
Q
F
E
A
M
-
A
----
K
-
D
Q
-
E
G
------
E
R
K
L
E
K
K
S
I
Q
N
L
Y
I
------
P
N
L
G
D
-
I
D
D
V
L
K
Q
D
L
I
E
E
V
R
E
I
H
-----
F
F
D
L
--------
C
---
R
P
R
V
R
K
L
D
--
L
L
W
A
K
V
F
W
S
G
N
E
M
S
K
-
T
K
E
A
A
E
L
-------------------------------------
47
Fugue
50.45
10%
2
- C3 -
2AR0
7
T1MK_ECOLI
A:
[6-529]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
L
V
A
K
L
W
---------------
K
L
C
D
N
L
R
-
D
G
------
G
V
S
Y
Q
N
Y
---
V
N
E
-
L
A
S
L
L
F
L
K
M
C
K
E
T
GQE
A
E
Y
L
P
E
G
Y
-
R
W
D
D
-
L
K
S
R
I
G
Q
E
--------
Q
L
Q
F
Y
R
K
M
L
V
--
H
L
G
E
D
D
K
K
L
V
Q
A
V
F
---------
H
N
V
S
T
T
I
T
E
P
K
Q
I
T
A
L
V
-----
S
N
M
D
S
L
D
W
Q
Y
F
TP
R
P
L
I
K
T
I
I
H
L
L
K
P
Q
P
R
E
V
V
Q
D
P
A
AG
T
-
A
G
F
L
I
E
A
D
R
Y
V
K
S
Q
T
N
D
L
D
D
L
D
G
D
T
Q
D
F
Q
I
H
R
A
F
I
G
L
E
L
V
P
G
T
R
---
R
L
---------
A
L
M
N
C
L
L
H
D
I
E
G
N
-----
L
D
-----
H
G
G
A
I
---------
R
L
G
N
T
---------
L
G
S
D
-
G
E
N
L
P
K
A
H
I
V
A
T
N
P
P
F
G
---------------------
S
A
A
G
T
N
---------------------
I
T
R
---
T
--
F
-
V
H
P
-
T
S
N
K
Q
L
C
F
M
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
E
--
G
-
G
K
G
T
D
-
I
-
R
R
D
L
M
D
K
C
H
L
H
T
I
L
R
L
P
-
T
G
I
F
Y
A
-
Q
G
-
V
-------------
K
T
N
V
L
F
F
T
-----------
K
G
T
V
--
A
---
N
P
N
Q
D
K
--
N
C
T
D
--
D
V
W
--
V
Y
D
--
L
---
R
----------
T
--
N
M
P
S
F
G
-----
K
R
T
P
-
F
T
---
D
E
H
L
Q
P
F
-------
E
R
V
Y
G
E
---------
D
-
P
H
G
L
S
P
R
T
-
E
G
E
W
S
F
N
A
E
E
----------
T
E
V
A
D
S
E
----
E
N
-
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
A
K
S
DSLDISW
L
K
D
-------
K
D
-
P
E
P
D
V
L
A
A
E
-------------------
A
M
-
G
E
L
V
Q
-
A
L
S
E
-
L
D
-----------------------------------------
A
L
M
R
E
L
G
-----
A
S
D
E
A
D
-
L
Q
R
Q
L
L
-
E
E
-
A
F
G
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
48.80
27%
-40
- C3 -
2IBT
5
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.78
27%
-42
- C3 -
2IH5
4
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
--------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.27
27%
-39
- C3 -
2JG3
6
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
S
----------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.13
27%
-37
- C3 -
2NP6
3
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYPIH
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.08
27%
-36
- C3 -
2IH4
4
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYPIH
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.05
27%
-41
- C3 -
2IH2
5
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.71
27%
-39
- C3 -
2IBS
3
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
47.32
27%
-40
- C3 -
1G38
3
MTTA_THEAQ
A:
[71-192]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYPIH
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.17
27%
-37
- C3 -
2NP7
5
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
KYP
I
H
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.05
27%
-34
- C3 -
2ADM
1
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
--------
V
F
K
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
T
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
46.99
27%
-30
- C3 -
1AQJ
1
MTTA_THEAQ
A:
[91-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
L
W
E
P
-
G
E
--
A
-
F
D
L
I
L
G
N
P
P
Y
G
I
V
------------
A
-----
V
K
D
L
Y
K
K
---------------------
A
F
S
---
T
--
W
-
K
G
K
-
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
L
K
-------
P
-------
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
-
D
F
A
L
L
-
R
-
E
F
L
A
-
R
E
G
K
T
S
V
Y
Y
--
L
-
G
E
V
F
P
Q
-
K
K
-
V
-------------
S
A
V
V
I
R
F
Q
-----------
K
S
G
K
--
G
---
L
S
L
W
D
T
--
Q
E
S
E
--
S
G
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
-
H
W
E
G
-----
E
I
I
R
-
F
E
---
T
E
E
T
R
K
L
-------
E
I
S
G
M
P
---------
L
-
G
D
L
F
H
I
R
F
-
A
A
R
S
P
E
F
K
K
H
----------
P
A
V
R
K
E
P
----
G
P
-
G
L
V
P
V
L
T
G
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
-------
W
M
P
-------
K
E
-
R
A
K
E
L
R
D
F
Y
-------------------
A
--
T
P
H
L
V
-
V
A
H
T
-
K
G
-----------------------------------------
T
R
-
V
V
A
A
-----
W
D
E
R
A
Y
-
P
W
R
E
E
F
-
H
L
-
L
P
K
E
G
V
--
R
L
D
P
----------------------------------------------------
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
-
H
--
V
R
T
L
Y
R
-
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
-
Y
----
G
F
H
T
-----------------------------------------------------------------------------------------------------------------------------------------------