@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1386: (2015-12-07 )
MKIGIDKIGFATSQYVLEMTDLAIARQVDPEKFSKGLLLDSLSITPVTEDIVTLAASAANDILSDEDKETIDMVIVATESSIDQSKAASVYVHQLLEIQPFARSFEMKEACYSATAALDYAKLHVEKHPDSKVLVIASDIAKYGIKSTGESTQGAGSIAMLISQNPSILELKEDRLAQTRDIMDFWRPNYSDVPYVNGMFSTKQYLDMLKTTWKEYQKRFNTSLSDYAAFCFHIPFPKLALKGFNKILDNNLDEQKKAELQENFEHSITYSKKIGNCYTGSLYLGLLSLLENSQNLKAGDQIAFFSYGSGAVAEIFTGQLVDGYQNKLQSDRMDQLNKRQKITVTEYEKLFFEKTILDENGNANFNTYRTGTFSLDSICEHQRIYKKINN
Atome Classification :
(20 SA)
-.........10........20......-.-----------.30........40......-------------------------..50........60...--..--...70........80........90.......--.--100--....-...110.......120....--...--130-.-......140....---------.---..150.......160.......170--...----.....-.180....-.---...190.--...-....200.......210....------...220--..-----------.------......230.......240-.-----....------------------------------------..--------------------------------250------..---...------------------------...--------260-......----------...270---------.........280.......290..----...-....300-.........310.....---------..320....-----..-.330-....--....340.......350----.--........360.....--------..370.......-380........390-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MKIGIDKIGFA
T
S
Q
Y
V
L
E
M
T
D
L
A
I
ARQ-V-----------
D
P
E
K
FSKG
L
L
LDSLSITPV-------------------------
T
E
D
I
V
T
L
A
A
S
A
A
N
D
ILS--DE--DKE
T
I
D
M
V
I
V
ATESSI
D
Q
S
K
A
A
S
V
Y
V
H
Q
L
L
EI--
Q
--
P
F
A
--
R
S
F
E
-
M
K
E
A
C
Y
S
A
T
A
A
L
D
Y
A
K
L
H
V
E--KHP--D
S
K
-
V
-
L
V
I
A
S
D
I
A
K
YGIK---------S---TGESTQGA
G
S
I
A
M
L
ISQNP
S
I
L
E
----
L
K
E
----
D
R
L
A
Q
-
T
R
-
D
I
M
D
F
-W---RPNY-SD--VPY-VNGMF
S
T
K
Q
Y
L
D
M
L
K
T
T
W
K
E
Y
------
Q
K
R
F----NT-----------
S
------
L
S
D
Y
A
A
F
C
FHIP
F
P
K
L
A
L
K
-
G
-----
F
N
K
I
------------------------------------
L
D--------------------------------NN-------L
D
---
E
Q
K
------------------------
K
A
E
--------
L
---
Q
E
NF
E
H
----------S
I
T
Y
-----------SKKIGNCYT
G
S
L
Y
L
G
L
L
S
L
L
--EN----SQN-LKAG
D
---
Q
I
A
F
F
SYGS
G
A
V
A
E
I
F
T
---------
G
Q
L
V
D
G
Y
Q
N
-----
K
L
-
Q
S
-
D
-
R
M
D
Q
--
L
NKRQ
K
I
T
V
T
E
Y
E
K
L
------
F
--
F
E
K
T
ILDENGNAN
F
N
T
--------
Y
R
TGTF
S
L
D
S
I
C
-
E
-
H
Q
R
I
Y
K
K
INN---------
56
Fugue
95.29
51%
-92
- C3 -
1X9E
2
HMGCS_ENTFL
A:
[1-383]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
-----
L
L
A
K
------------------------------------
I
S
--------------------------------
D
Q
-------
T
----
E
A
E
------------------------
Q
E
R
--------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
Q
K
E
-
T
-
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
------------
L
K
Y
S
I
S
A
I
N
-
N
-
T
V
R
S
Y
R
N
------------
4
PsiBlast_PDB
92.20
49%
-97
- C3 -
1XPK
3
?
C:
[2-364]
--
T
I
G
I
D
K
I
N
F
Y
V
P
K
Y
Y
V
D
M
A
K
L
A
E
A
R
Q
-
V
-----------
D
P
N
K
F
L
I
G
I
G
Q
T
E
M
A
V
S
P
V
-------------------------
N
Q
D
I
V
S
M
G
A
N
A
A
K
D
I
I
T
--
D
E
--
D
K
K
K
I
G
M
V
I
V
A
T
E
S
A
V
D
A
A
K
A
A
A
V
Q
I
H
N
L
L
G
I
--
Q
--
P
F
A
--
R
C
F
E
-
M
K
E
A
C
Y
A
A
T
P
A
I
Q
L
A
K
D
Y
L
A
--
T
R
P
--
N
E
K
-
V
-
L
V
I
A
T
D
T
A
R
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
V
I
A
H
N
P
S
I
L
A
----
L
N
E
----
D
A
V
A
Y
-
T
E
-
D
V
Y
D
F
-
W
---
R
P
T
G
-
H
K
--
Y
P
L
-
V
D
G
A
L
S
K
D
A
Y
I
R
S
F
Q
Q
S
W
N
E
Y
------
A
K
R
Q
----
G
K
-----------
S
------
L
A
D
F
A
S
L
C
F
H
V
P
F
T
K
M
G
K
K
-
A
-----
L
E
S
I
------------------------------------
I
D
---------------------------------
N
-------
A
D
---
E
T
T
------------------------
Q
E
R
--------
L
---
R
S
G
Y
E
D
----------
A
V
D
Y
-----------
N
R
Y
V
G
N
I
Y
T
G
S
L
Y
L
S
L
I
S
L
L
--
E
N
-----
R
D
-
L
Q
A
G
E
---
T
I
G
L
F
S
Y
G
S
G
S
V
G
E
F
Y
S
---------
A
T
L
V
E
G
Y
K
D
-----
H
L
D
Q
A
-
A
-
H
K
A
L
--
L
N
N
R
T
E
V
S
V
D
A
Y
E
T
F
------
F
KR
F
D
D
V
E
F
D
E
E
Q
D
A
V
H
E
D
--------
R
H
I
F
Y
L
S
N
I
E
N
N
-
V
-
R
E
Y
H
R
P
E
------------
23
PsiBlast_CBE
92.11
55%
-96
- C3 -
3V4X
2
HMGCS_ENTFL
B:
[6-358]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
24
PsiBlast_CBE
91.18
54%
-97
- C3 -
1YSL
4
HMGCS_ENTFL
B:
[20-372]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
1
PsiBlast_PDB
91.05
55%
-94
- C3 -
3V4X
2
HMGCS_ENTFL
A:
[6-358]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
21
PsiBlast_CBE
90.72
55%
-94
* C3 *
3V4X
1
HMGCS_ENTFL
D:
[6-358]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
22
PsiBlast_CBE
90.17
55%
-93
- C3 -
3V4X
1
HMGCS_ENTFL
C:
[6-358]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
26
PsiBlast_CBE
90.11
54%
-95
- C3 -
2HDB
3
HMGCS_ENTFL
B:
[1-353]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
G
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
2
PsiBlast_PDB
89.87
54%
-94
- C3 -
1X9E
2
HMGCS_ENTFL
A:
[1-353]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
25
PsiBlast_CBE
89.79
54%
-93
- C3 -
1X9E
2
HMGCS_ENTFL
B:
[1-353]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
3
PsiBlast_PDB
89.45
54%
-94
- C3 -
2HDB
2
HMGCS_ENTFL
A:
[1-353]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
-
V
-----------
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
-------------------------
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
G
I
--
Q
--
P
F
A
--
R
S
F
E
-
I
K
E
G
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
A
--
L
H
P
--
D
K
K
-
V
-
L
V
V
A
A
D
I
A
K
Y
G
L
N
---------
S
---
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
I
L
A
----
L
K
E
----
D
N
V
M
L
-
T
Q
-
D
I
Y
D
F
-
W
---
R
P
T
G
-
H
P
--
Y
P
M
-
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
D
E
H
------
K
K
R
T
----
G
L
-----------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
----
L
A
K
I
------------------------------------
S
D
--------------------------------
Q
T
-------
E
A
---
E
Q
E
------------------------
R
----------
I
---
L
A
R
Y
E
E
----------
S
I
I
Y
-----------
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
--
E
N
----
A
T
T
-
L
T
A
G
N
---
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
---------
G
E
L
V
A
G
Y
Q
N
-----
H
L
-
Q
K
-
E
T
H
L
A
L
--
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
------
F
--
A
E
T
L
D
T
D
I
D
Q
T
L
E
D
E
L
--------
K
Y
S
I
S
A
I
N
N
T
V
R
-
S
-
Y
R
N
----------------
8
PsiBlast_PDB
68.46
27%
-69
- C3 -
2WYA
2
HMCS2_HUMAN
A:
[17-457]
-------------
A
Q
Y
V
-
D
Q
T
D
L
E
K
Y
N
N
-
V
-----------
E
A
G
K
Y
T
V
G
L
G
Q
T
R
M
G
F
C
S
V
-------------------------
Q
E
D
I
N
S
L
C
L
T
V
V
Q
R
L
M
E
R
I
Q
L
--
P
W
D
S
V
G
R
L
E
V
G
T
E
T
I
I
D
K
S
K
A
V
K
T
V
L
M
E
L
F
Q
D
--
S
--
G
N
T
D
I
E
G
I
D
-
T
T
N
A
C
Y
G
G
T
A
S
L
F
N
A
A
N
W
M
E
--
S
S
S
W-
D
G
R
Y
A
-
M
V
V
C
G
D
I
A
V
Y
-
P
S
---------
G
---
N
A
R
P
T
G
G
A
G
A
V
A
M
L
I
G
P
K
A
P
L
A
L
----
E
R
G
----
L
R
G
T
H
-
M
E
-
N
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
I
-
V
D
G
K
L
S
I
Q
C
Y
L
R
A
L
D
R
C
Y
T
S
Y
------
R
K
K
I
----
Q
N
Q
W
K
Q
A
GSD
R
P
F
T
------
L
D
D
L
Q
Y
M
I
F
H
T
P
F
C
K
M
V
Q
K
-
S
L
A
R
L
M
F
N
D
F
------------------------------------
L
S
--------------------------------
A
S
-------
S
D
---
T
Q
T
S
LYKGLEAFGGLKLEDTYTN
K
D
L
D
K
A
L
--------
L
K
A
S
Q
D
M
F
D
K
KTKA------
S
L
Y
L
-----------
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
L
A
S
L
L
S
H
H
S
----
A
Q
E
-
L
-
A
G
S
---
R
I
G
A
F
S
Y
G
S
G
L
A
A
S
F
F
S
F
R
V
S
QDAAP
G
S
P
L
D
K
L
V
S
-----
S
--
T
S
-
D
-
L
P
K
R
--
L
A
S
R
K
C
V
S
P
E
E
F
T
E
I
M
N
Q
R
E
Q
F
--
Y
H
K
V
N
F
S
P
P
G
D
T
--
N
S
--------
L
F
P
G
T
W
Y
L
E
R
V
D
-
E
Q
H
R
R
K
Y
A
R
R
P
V
---------
6
PsiBlast_PDB
68.08
29%
-92
- C3 -
2F9A
1
?
A:
[33-371]
--------------------------------------------
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
-------------------------
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
E
K
CG
N
--
T
D
V
--
E
G
V
D
-
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
E
--
S
N
S
W-
D
G
R
-
Y
G
L
V
I
C
T
D
S
A
V
Y
A
-
E
---------
G
---
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
I
V
F
----
E
S
K
----
L
R
G
S
H
-
M
A
-
H
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
V
-
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
------
C
N
K
F
----
E
K
L
EG
K
E
F
-----
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
-----
F
A
R
L
------------------------------------
L
Y
------------------------------------------------------------------------------------------------------------YDAKVQPTTL
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
--
H
N
----
K
H
S
-
D
L
A
G
K
---
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
---------
L
R
L
C
E
N
Q
S
P
-----
F
S
-
L
S
-
N
-
I
A
S
V
--
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
------
E
--
K
F
V
E
T
M
K
L
M
E
H
R
Y
G
A
K
--------
E
F
V
T
S
K
E
G
I
L
D
L
-
L
-
A
P
G
T
Y
Y
L
K
E
V
---------
5
PsiBlast_PDB
64.35
29%
-83
- C3 -
2F82
-
?
A:
[34-372]
--------------------------------------------
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
-------------------------
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
E
K
CG
N
--
T
D
V
--
E
G
V
D
-
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
E
--
S
N
S
W-
D
G
R
-
Y
G
L
V
I
C
T
D
S
A
V
Y
A
-
E
---------
G
---
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
I
V
F
----
E
S
K
----
L
R
G
S
H
-
M
A
-
H
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
V
-
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
------
C
N
K
F
----
E
K
L
EG
K
E
F
-----
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
-----
F
A
R
L
------------------------------------
L
Y
--------------------------------
N
D
F
L
R
NASS
I
D
---
E
A
A
------------------------
K
E
K
F
TPYSSLS
L
---
D
E
S
Y
Q
S
R
D
L
E
K
V
S
Q
Q
L
A
K
T
Y
Y
D
A
KVQPTTL
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
--
H
N
----
K
H
S
-
D
L
A
G
K
---
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
---------
L
R
L
C
E
N
Q
S
P
-----
F
S
-
L
S
-
N
-
I
A
S
V
--
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
------
E
--
K
F
V
E
T
M
K
L
M
E
H
R
Y
G
A
K
--------
E
F
V
T
S
K
E
G
I
L
D
L
-
L
-
A
P
G
T
Y
Y
L
K
E
V
---------
27
HHSearch
63.45
27%
-61
- C3 -
2F82
-
?
A:
[3-451]
-
K
N
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
-
A
-----------
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
-------------------------
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
E
K
Y
K
I
--
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
E
K
--
C
GN
T
D
V
--
E
G
V
D
-
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
E
--
S
N
S
WD
G
R
Y
-
G
-
L
V
I
C
T
D
S
A
V
Y
A
E
G
-------------
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
-
I
V
----
F
E
S
K---
L
R
G
S
H
-
M
A
-
H
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
V
-
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
C
N
K
F
E
K
L
E
G
K
----
E
F
-----------
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
S
F
-----
A
R
L
L
------------------------------------
Y
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
E
S
Y
Q
S
R
D
L
-------
E
K
V
S
Q
Q
L
A
------------------------
K
T
Y
--------
Y
---
D
A
K
V
Q
P
----------
T
T
L
V
-----------
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
--
H
N
----
K
-
H
S
D
L
A
G
K
---
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
---------
L
R
L
C
E
N
Q
S
P
FS
L
S
N
I
A
-
S
V
M
D
-
V
G
G
K
--
L
K
A
R
H
E
Y
A
P
E
K
F
V
E
T
------
M
--
K
L
M
E
H
R
Y
G
A
K
--
E
F
V
T
S
KEGILDL
L
A
P
G
T
Y
Y
L
K
E
V
D
S
L
-
Y
R
R
F
Y
G
K
K
-----------
59
Fugue
62.68
26%
-58
- C3 -
2F82
-
?
A:
[2-451]
A
K
N
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
-
A
-----------
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
-------------------------
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
E
K
--
C
GN
T
D
V
--
E
G
V
D
-
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
E
SN
S
W
D
--
G
R
Y
-
G
-
L
V
I
C
T
D
S
A
V
Y
-
A
E
---------
G
---
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
I
V
F
----
E
S
K
----
L
R
G
S
H
-
M
A
-
H
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
V
-
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
------
C
N
K
F
----
E
K
-----------
L
EG
K
E
F
S
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
-----
F
A
R
L
L
Y
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
E
S
Y
Q
S
R
D
L
E
--------------------------------
K
V
-------
S
Q
---
Q
L
A
------------------------
K
T
Y
--------
Y
---
D
A
K
V
Q
P
----------
T
T
L
V
-----------
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
--
H
N
----
K
H
S
-
D
L
A
G
K
---
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
---------
L
R
L
C
E
N
Q
S
P
-----
F
S
-
L
S
-
N
-
I
A
S
V
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
E
K
------
F
--
V
E
T
M
K
L
M
E
H
R
Y
G
A
K
E
F
--------
V
T
S
K
E
G
I
L
D
L
L
A
-
P
-
G
T
Y
Y
L
K
E
V
D
S
LY
R
R
F
Y
G
K
K
52
HHSearch
62.58
17%
-82
- C3 -
3WD8
1
?
A:
[28-401]
--
P
A
S
I
L
A
I
G
T
A
N
P
P
T
C
F
N
Q
S
D
Y
P
D
F
Y
F
R
V
T
DCEHK
T
E
L
K
D
K
F
K
R
I
C
D
R
S
A
V
K
K
R
Y
L
H
V
T
E
E
V
L
K
E
N
PSMRSYNAPS
L
D
A
R
Q
A
L
L
I
E
Q
V
P
K
L
G
K
E
A
A
A
K
A
I
K
E
W
G
Q
--
P
L
S
K
I
T
H
L
V
F
S
A
M
A
G
V
D
-
I
P
G
A
D
L
R
L
M
N
L
L
G
L
--
E
--
P
S
V
--
K
R
L
M
I
Y
S
Q
G
C
F
I
G
G
A
A
I
R
C
A
K
D
F
A
E
--
N
N
A
--
G
A
R
-
V
-
L
V
V
F
S
D
I
M
N
M
Y
F
H
EPQEAHL
D
I
L
---
V
G
Q
A
V
F
G
D
G
A
A
A
V
I
V
G
A
D
P
E
V
S
I
ERPL
F
H
V
V---
S
S
T
Q
M
S
V
P
-
D
T
N
K
F
-
I
---
R
A
H
V
-
K
E
--
M
G
---
M
E
L
Y
L
S
K
D
V
P
A
T
V
G
K
N
I
E
K
L
------
L
V
D
A
V
S
PF
G
I
-----------
S
------
D
W
N
S
L
F
Y
S
V
H
P
G
G
R
A
I
L
D
Q
-
V
-----
E
L
N
L
------------------------------------
G
L
--------------------------------
G
-------------------------------------------------------
K
E
K
L
R
A
----------
S
R
H
V
-----------
L
S
E
Y
G
N
M
G
G
S
S
V
Y
F
I
L
D
E
I
R
--
K
K
S
M
Q
E
A
-
K
-
P
T
T
G
D
GLE
W
G
V
L
F
A
I
G
P
G
L
T
V
E
T
V
I
---------
L
L
S
V
P
I
--------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.82
29%
-82
- C3 -
2FA0
1
?
A:
[33-371]
--------------------------------------------
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
-------------------------
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
E
K
CG
N
--
T
D
V
--
E
G
V
D
-
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
E
--
S
N
S
W-
D
G
R
-
Y
G
L
V
I
C
T
D
S
A
V
Y
A
-
E
---------
G
---
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
I
V
F
----
E
S
K
----
L
R
G
S
H
-
M
A
-
H
V
Y
D
F
-
Y
---
K
P
N
L
A
S
E
--
Y
P
V
-
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
------
C
N
K
F
----
E
K
L
EG
K
E
F
-----
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
-----
F
A
R
L
------------------------------------
L
Y
--------------------------------
N
D
F
L
R
NASS
I
D
---
E
A
A
------------------------
K
E
K
F
TPYSSLS
L
---
D
E
S
Y
Q
S
R
D
L
E
K
V
S
Q
Q
L
A
K
T
Y
Y
D
A
KVQPTTL
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
--
H
N
----
K
H
S
-
D
L
A
G
K
---
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
---------
L
R
L
C
E
N
Q
S
P
-----
F
S
-
L
S
-
N
-
I
A
S
V
--
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
------
E
--
K
F
V
E
T
M
K
L
M
E
H
R
Y
G
A
K
--------
E
F
V
T
S
K
E
G
I
L
D
L
-
L
-
A
P
G
T
Y
Y
L
K
E
V
---------
47
HHSearch
61.25
17%
-78
- C3 -
2EBD
-
FABH_AQUAE
A:
[1-309]
-
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
V
D
-
T
-----------
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
--------------------------
E
E
T
I
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
--
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
--
K
---
G
V
--
Y
A
F
D
-
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
--
S
G
K
--
A
K
N
-
V
-
L
V
I
G
A
E
K
L
S
E
A
V
D
WED------
R
---
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
----
I
L
-----
A
T
R
M
Y
-
A
E
G
S
L
E
E
L
-
L
---
H
A
D
N
-
C
G
--
Y
I
R
-
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
------
L
E
K
A
----
G
V
-----------
K
------
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
-
L
-----
A
E
K
L
------------------------------------
N
I
--------------------------------
P
-------------------------------------------------------
K
E
K
V
F
V
-------------
N
-----------
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
--
K
E
----
G
-
K
-
V
K
R
G
D
---
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
---------
L
R
Y
-----------------------------------------------------------------------------------------------------------
34
HHSearch
58.72
18%
-73
- C3 -
1UB7
4
?
A:
[2-321]
---
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
L
D
-
T
-----------
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
-------------------------
D
E
Y
T
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
--
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
--
K
----
A
--
F
A
Y
D
-
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
--
A
G
L
--
A
Q
K
-
V
-
L
A
V
G
A
E
A
L
S
K
I
I
D
---------
W
NDR
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
----
F
R
S
F
V
L
G
A
D
G
T
G
-
A
K
-
E
L
Y
H
A
C
V
APR
L
P
D
G
-
T
S
MK
N
R
L
Y
M
N
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
------
I
E
K
A
----
G
L
-----------
T
------
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
-
A
-----
R
E
R
L
------------------------------------
G
L
--------------------------------
P
-------------------------------------------------------
W
E
R
V
A
V
----------
N
--------------
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
----
G
-
R
-
I
R
E
G
D
---
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
---------
L
T
W
G
G
A
--------------------------------------------------------------------------------------------------------