@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1403: (2015-12-07 )
MKKKIILKSSVLGLVAGTSIMFSSAFADQVGVQVIGVNDFHGALDNTGTANMPDGKVTNAGTAAQLDAYIDDAQKDFKQTNPNGESIRVQAGDMVGASPANSGLLQDEPTVKTFNAMNVEYGTLGNHEFDEGLAEYNRIVTGKAPAPDSNINNITKSYPHEAAKQEIVVANVIDKVNKQIPYNWKPYAIKNIPVNNKSVNVGFIGIVTKDIPNLVLRKNYEQYEFLDEAETIVKYAKELQAKNVKAIVVLAHVPATSKDDIAEGEAAEMMKKVNQLFPENSVDIVFAGHNHQYTNGLVGKTRIVQALSQGKAYADVRGVLDTDTQDFIETPSAKVVAVAPGKKTGSADIQAIVDQANTIVKQVTEAKIGTAEVSGMITRSVDQDNVSPVGSLITEAQLAIARKSWPDIDFAMTNNGGIRADLLIKPDGTITWGAAQAVQPFGNILQVVEITGRDLYKALNEQYDQKQNFFLQIAGLRYTYTDNKEGGEETPFKVVKAYKSNGEEINPDAKYKLVINDFLFGGGDGFASFRNAKLLGAINPDTEVFMAYITDLEKAGKKVSVPNNKPKIYVTMKMVNETITQNDGTHSIIKKLYLDRQGNIVAQEIVSDTLNQTKSKSTKINPVTTIHKKQLHQFTAINPMRNYGKPSNSTTVKSKQLPKTNSEYGQSFLMSVFGVGLIGIALNTKKKHMK
Atome Classification :
(20 SA)
------------------------.........10........20........----30-------........40........50........60.--.......70........80........90........100.....-..110.......120.......130.......140.......150.......160.......170...--....180.......190.......200....----...210...-....220...---....230.......240........250--.......260.-------------------......270...----....280.----------------------.......----.290-------------..--..-------------------...300-----------------.....----....310-...------...---.-.320.....-..330....--...340------.........350.......360-------.........370.......380.......----390......-----.400..-----.....410.......420.......430.......440.-......450.......460-.....---.-----...---------470..-.....480.......490..-.....500-.......---..510.......520.......530.--..--....---540-.........550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------MK
K
K
I
I
L
KSS
V
L
G
L
VAG
T
S
I
M
FSSAFADQ----V
G
-------
V
Q
V
I
GVNDFHGALDNTGTANMPDGKVTNAG
T
--
A
A
Q
L
D
A
Y
I
D
D
A
Q
K
D
F
K
QTNPNG
E
S
I
R
V
QAGDMVGASPANSGLLQD-EPT
V
K
T
F
N
A
M
N
V
E
YGTLG
N
H
E
F
D
E
G
L
A
E
Y
N
R
IVTGKAPAPDS
N
I
N
N
I
T
K
SY
P
H
E
A
A
K
Q
E
I
V
V
A
N
V
I
D
K
--
V
N
KQIPYNWKP
Y
A
I
K
NIPVNNK
S
V
N
V
G
F
I
G
I
----VTKDI
P
N
L
V
-
L
RKN
Y
E
Q
Y
E
F
---
L
D
E
A
E
T
I
V
K
Y
A
K
E
L
QA-KN
V
K
A
I
V
V
L
A
H--VPATSKDDIAE-------------------G
E
A
A
E
M
M
K
K
V
N
Q
----LFPEN--S----------------------
V
D
I
V
F
AG----HNHQ-------------YT--NG-------------------LV
G
K
-------------------
T
R
I
V
Q
----
A
L
SQGK--
A
Y
A
------
D
V
R---G-VLDTD
T
Q
D
F
-IETPS
A
K
V
V
--
A
VAP--------GKKTG
S
A
D
I
Q
A
I
V
D
Q
A
N
T
I
V
---------
K
Q
V
T
E
AKIG
T
A
E
VS
G
M
I
T
RSVDQDNV
S
P
V
----
G
S
L
I
T
E
A
Q
L
-----
A
I
ARKS-----WPDI
D
F
A
MTNNG
G
I
R
A
D
L
L
IKPD
G
T
I
TW
G
A
A
Q
A
V
Q
P
F
G
N
-
I
L
Q
V
V
EIT
G
R
D
L
Y
K
A
L
N
---
E
Q
Y
D
Q
---
K
-----Q
N
F
---------
F
L
Q
I
A-G
L
R
Y
T
YTDNKEGGEET
P
F
K
V
-
V
K
A
Y
KS---NGEEINP---DA
K
Y
K
L
V
I
N
D
F
L
FGGGD
G
F
A
SFRN
A
K
--
L
L
--GAIN---P---
D
T
E
V
F
M
A
Y
I
T
D
L
E
KAG
K
K
VSVPNNK
P
K
I
Y
V
T
M
KMV
N
E
TITQND
G
T
H
S
I
I
K
K
L
Y
LDRQGN
I
V
A
Q
E
I
V
S
D
T
L
N
QTKSKSTKINP
V
T
T
I
H
K
K
Q
L
H
Q
FTAINP
M
R
NYGKPSNSTTVKSKQLPKT
N
S
E
Y
G
Q
S
F
L
M
S
V
F
G
V
G
L
I
G
I
A
LNTKKKHMK
26
HHSearch
96.90
25%
-59
- C1 -
2Z1A
4
?
A:
[28-534]
---------------------------------------------------------
F
T
-------
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
L
S
--
G
E
K
T
P
V
G
G
--
V
A
R
R
V
A
L
F
D
R
V
W
A
R
------
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
-
F
N
Q
Y
R
G
-
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
--------------------
G
A
R
F
K
V
V
S
A
N
V
D
A
S
--
R
E
P
R
L
K
G
L
F
A
P
Y
A
V
V
V
V
G
----
G
E
R
V
G
I
I
G
L
----
T
T
P
D
T
R
E
I
S
-
N
P
G
--
P
T
V
A
F
---
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
--
L
G
Y
G
E
D
L
---------------------------
K
L
A
R
R
L
----------
V
--
G
----------------------
V
Q
V
I
V
G
G
----
H
S
H
T
-------------
L
L
--
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
G
K
D
-------------------
V
L
V
V
Q
----
A
W
E
W
G
K
--
V
V
G
------
L
L
E
---
V
-
T
F
D
A
K
G
E
-
L
-
L
-
A
Y
K
G
E
A
L
--
L
M
T
P
--------
E
A
A
P
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
---------
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
R
R
E
S
N
L
----
G
N
L
I
T
D
G
M
L
-----
W
K
T
R
N
-------
A
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
---
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
---
N
G
V
S
Q
WEN
T
-----
A
G
R
---------
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
A
----
G
S
R
V
-
V
R
V
E
V
K
T
EK
G
Y
V
P
L
D
L
---
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
--
G
Y
RV
D
T
G
F
---
S
---
D
A
E
S
F
M
D
Y
L
K
E
L
----
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
---------------------------------------------------------------------------------------------------------------------
28
HHSearch
91.49
23%
-64
- C1 -
1HP1
7
USHA_ECOLI
A:
[3-499]
-------------------------------------------------
Q
D
K
T
----
Y
K
-------
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
---------
G
E
Y
G
--
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
--
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
-
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
--------------------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
-
R
-
L
F
K
P
W
A
L
F
K
R
Q
----
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
---
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
G
H
Y
D
N
G
E
H
G
S
NA-----------------
P
G
D
V
E
M
A
R
A
L
--------
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
-------------
P
V
--
C
M
AAENKKQVDYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------------
I
W
I
V
Q
----
A
H
E
W
G
K
--
Y
V
G
------
R
A
D
---
F
-
E
F
R
N
G
E
M
K
M
----
V
N
Y
Q
L
I
--
P
V
N
L
KKKRVLYT
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
---------
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
----
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
---
A
V
A
Q
M
KP-
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
---------
G
K
L
-
N
D
L
K
-
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
--
G
Y
V-
N
T
G
F
---
I
---
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.23
23%
-58
- C1 -
1USH
7
USHA_ECOLI
A:
[26-530]
---------------------------------------------------
Y
E
QD
K
T
Y
K
-------
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
--------
E
Y
G
E
Y
G
L
--
A
A
Q
-
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
--
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
--
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
--------------------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
27
HHSearch
91.09
24%
-45
- C1 -
3IVE
5
?
A:
[4-501]
----------------------------------------------------
A
----
K
D
-------
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
I
A
-
D
G
K
R
D
I
G
G
--
W
A
N
I
T
T
L
V
K
Q
E
K
A
K
------
N
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
-
S
S
L
T
K
G
-
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
--------------------
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
--
N
S
S
K
-
S
F
W
D
K
P
Y
T
I
I
E
K
D
----
G
V
K
I
G
V
I
G
L
----
H
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
---
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
H
--
E
G
V
P
A
R
Q
S
S
M
-D
V
R
R
A
L-------------
D
K
D
I
Q
T
A
S
Q
----------
V
K
--
G
----------------------
L
D
I
L
I
T
G
----
H
A
H
V
-------------
G
T
--
P
E
P
I
-----------------
K
V
G
N
-------------------
T
L
I
L
S
----
T
D
S
G
G
I
--
D
V
G
------
K
L
V
---
L
-
D
Y
K
E
K
P
H
N
F
-
T
V
-
K
N
F
E
L
K
--
T
I
Y
A
--------
D
E
W
K
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
K
L
---------
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
--
K
R
--
A
Y
G
E
S
A
S
L
----
G
N
L
A
A
D
A
L
L
-----
A
A
A
G
K
--------
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
---
P
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
---
H
G
A
S
L
---------
S
N
G
---------
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
----
G
Q
R
V
-
I
T
L
T
-
L
---
N
G
K
P
I
E
D
---
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
--
A
R
N
I
T
G
G
Y
---
Y
---
V
Y
H
A
V
V
D
Y
F
K
A
G
----
N
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
---------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.23
23%
-58
- C1 -
2USH
7
USHA_ECOLI
A:
[26-530]
---------------------------------------------------
Y
E
QD
K
T
Y
K
-------
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
--------
E
Y
G
E
Y
G
L
--
A
A
Q
-
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
--
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
--
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
------
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQV
D
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
----------------
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
------------------
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
--------------------------------------------------------------------------------------------------------------------------
46
Fugue
87.87
20%
-37
- C1 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
--------------------------------------------------
H
K
A
----
V
E
-------
L
S
I
L
H
I
N
D
H
H
S
Y
L
E
P
H
E
T
R
I
N
L
N
G
Q
Q
T
K
V
D
I
G
G
F
S
A
V
N
A
K
L
N
K
L
R
K
K
------
Y
K
N
P
L
V
L
H
A
G
D
A
I
T
G
T
L
Y
F
T
-
L
F
G
G
-
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
D
A
G
N
E
G
L
L
K
L
L
--------------------
E
P
L
K
I
P
V
L
S
A
N
V
I
P
D
--
K
S
S
I
L
Y
N
K
W
K
P
Y
D
I
F
T
V
----
D
G
E
K
I
A
I
I
G
L
----
D
T
V
N
K
T
V
N
S
-
S
S
P
G
-
K
D
V
K
F
---
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
Q
-
Q
G
I
N
K
I
I
L
L
S
H
--
A
G
S
E
K
N
I
E
I
A
Q
K
VNDID
V
I
V
T
G
DSHYLYGN
D
E
L
R
S
L
K
L
P
V
I
Y
----
E
Y
P
L
E
--
F
K
N
PNG
E
P
V
F
V
M
E
GWAYSA
V
V
G
D
L
G
V
K
F
S
P
EG
I
A
S
I
T
R
-------------
K
I
--
P
H
-------------------
V
L
M
S
-------------------
S
H
K
L
Q
----
V
K
N
S
E
G
--
K
W
A
------
E
L
T
---
G
-
D
E
R
K
K
A
L
D
T
-
L
K
S
M
--
K
S
I
--
S
L
D
D
--------
H
D
A
K
T
D
K
L
I
A
K
Y
K
S
E
K
D
R
L
A
---------
Q
E
I
V
G
V
I
T
G
S
A
M
P
G
G
S
A
N
R
I
P
N
K
A
G
S
N
P
E
----
G
S
I
A
T
R
F
I
A
-----
E
T
M
Y
N
E
-----
L
K
T
V
D
L
T
I
Q
N
A
G
G
V
R
A
D
I
---
L
P
G
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
-
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
---
D
A
M
Q
F
---
A
L
VDGS
T
G
A
---------
F
P
Y
G
A
-
G
I
R
Y
E
A
N
E
T
P
N
A
E
G
K
R
L
V
S
V
E
V
L
N
K
T
Q
---
Q
W
E
P
I
D
D
---
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
D
G
Y
K
T
F
G
K
L
F
--
N
D
--
P
K
Y
E
---
G
---
V
D
T
-------------------------------------------------------
Y
L
P
D
A
E
S
F
I
K
F
M
K
K
H
P
H
F
E
A
Y
T
S
S
N
V
K
F
N
A
S
T
------------------------------------------------------------
2
PsiBlast_PDB
86.66
23%
-39
- C1 -
4H1S
4
5NTD_HUMAN
A:
[4-511]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
---
S
K
C
V
N
A
S
R
--
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
E
P
N
--
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
--------------
E
G
L
I
E
P
L
L
K
E
-----
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
--
L
P
V
G
D
E
V
V
--
G
I
V
G
Y
----
T
S
K
E
T
P
--
F
-
L
S
N
P
G
T
N
L
V
F
---
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
-------------------
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
G
N
PP
S
----------------------
K
E
V
P
A
G
K
----
Y
P
F
I
-------------
V
T
--
S
D
-------------------
D
G
R
K
-------------------
V
P
V
V
Q
----
A
Y
A
F
G
K
--
Y
L
G
------
Y
L
K
---
I
-
E
F
D
-
E
R
G
N
V
-
I
S
S
H
G
N
P
I
L
LN
S
S
I
P
--------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
N
Y
-----------
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
----
M
----
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
T
D
E
M
F
-----
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
N
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
---
S
-----
T
G
E
---------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
-
V
L
C
T
K
C
---
R
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
--
L
R
H
-
D
S
G
D
---
Q
---
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.77
22%
-38
- C1 -
4H2B
5
5NTD_HUMAN
A:
[27-534]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
---
S
K
C
V
D
A
S
R
--
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
E
P
N
--
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
S
A
S
G
P
------------------
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
--
L
P
V
G
D
E
V
V
--
G
I
V
G
Y
----
T
S
K
E
T
P
--
F
-
L
S
N
P
G
T
N
L
V
F
---
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
-------------------
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
G
N
PP
S
----------------------
K
E
V
P
A
G
K
----
Y
P
F
I
-------------
V
T
--
S
D
-------------------
D
G
R
K
-------------------
V
P
V
V
Q
----
A
Y
A
F
G
K
--
Y
L
G
------
Y
L
K
---
I
-
E
F
D
-
E
R
G
N
V
-
I
S
S
H
G
N
P
I
L
LD
S
S
I
P
--------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
---------
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
----
M
----
G
N
L
I
C
D
A
M
I
-----
N
N
N
L
R
H
ADEMF
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
---
S
-----
T
G
E
---------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
-
V
L
C
T
S
C
---
R
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
--
L
R
H
-
D
S
G
D
---
Q
---
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
----------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
84.62
23%
-60
- C1 -
1OI8
4
USHA_ECOLI
A:
[43-505]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
C
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
--
T
W
E
D
--------
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.42
23%
-60
- C1 -
4WWL
14
USHA_ECOLI
A:
[43-505]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
--
T
W
E
D
--------
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
TGF
C
---
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.26
23%
-60
- C1 -
1OID
1
USHA_ECOLI
A:
[43-505]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
C
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
--
T
W
E
D
--------
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
--
E
G
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
----
C
--
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.20
23%
-58
- C1 -
1HP1
6
USHA_ECOLI
A:
[43-496]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
R
--
V
L
Y
T
--------
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
---------
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.87
23%
-57
- C1 -
1HPU
3
USHA_ECOLI
A:
[43-505]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
S
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
--
T
W
E
D
--------
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
PFQNKG
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
E
G
--
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
------
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.72
23%
-63
- C1 -
1OIE
1
USHA_ECOLI
A:
[43-505]
------------------------------------------------------------------------------------------------------------------
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
--------------------
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
--
S
T
G
E
R
L
F
--
K
P
W
A
L
----
F
K
R
Q
D
L
K
I
A
V
I
G
L
----
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
--
Q
T
E
K
P
D
I
I
I
A
A
--
T
H
M
G
H
Y
D
N
G
E
H
-------------------
G
C
N
A
P
G
D
V
E
M
A
R
----
A
L
P
A
G
--
S
----------------------
L
A
M
I
V
G
G
----
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
P
C
K
P
D
Q
Q
NG-------------
I
W
I
V
Q
----
A
H
E
W
G
K
Y
V
G
R
A
------
D
F
E
F
R
N
G
-
E
M
K
M
V
N
Y
Q
L
-
I
P
V
N
L
K
K
K
V
----------------
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
--
E
T
N
G
R
L
--
E
G
D
R
D
K
V
R
F
V
QT
N
M
G
R
L
I
L
A
A
Q
M
-----
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
-----
S
G
A
---------
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
-----------
L
N
D
L
K
I
---
K
G
E
P
V
D
P
---
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
----
C
--
G
Y
V
N
---
T
GFI
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.34
23%
-39
- C1 -
4H2F
4
5NTD_HUMAN
A:
[23-513]
----------------------------------------------------
P
----
W
E
-------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
---
S
K
C
V
D
A
S
R
--
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
E
P
N
--
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
--------------
E
G
L
I
E
P
L
L
K
E
-----
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
--
L
P
V
G
D
E
V
V
--
G
I
V
G
Y
----
T
S
K
E
T
P
--
F
-
L
S
N
P
G
T
N
L
V
F
---
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
-------------------
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
G
N
PP
S
----------------------
K
E
V
P
A
G
K
----
Y
P
F
I
-------------
V
T
--
S
D
-------------------
D
G
R
K
-------------------
V
P
V
V
Q
----
A
Y
A
F
G
K
--
Y
L
G
------
Y
L
K
---
I
-
E
F
D
-
E
R
G
N
V
-
I
S
S
H
G
N
P
I
L
LD
S
S
I
P
--------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
---------
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
----
M
----
G
N
L
I
C
D
A
M
I
-----
N
N
N
L
R
H
ADEMF
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
---
S
-----
T
G
E
---------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
-
V
L
C
T
A
C
---
A
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
--
L
R
--
H
D
S
G
---
D
---
Q
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
---------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.17
24%
-34
- C1 -
3IVD
4
?
A:
[7-463]
------------------------------------------------------------------
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
I
A
D
G
K
-
R
D
I
G
G
--
W
A
N
I
T
T
L
V
K
------
Q
E
K
A
K
N
K
A
T
W
F
F
D
A
G
D
Y
F
-
T
G
P
Y
I
S
S
L
T
K
G
-
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
--------------
D
N
T
L
L
Q
L
S
Q
------
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
--
N
S
S
K
S
F
W
D
-
K
P
Y
T
I
----
I
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
V
S
A
A
-
T
R
V
G
I
E
A
R
------
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
G
-
K
-
V
D
L
T
V
A
L
I
H
EG
V
P
A
R
Q
S
S
M
G
G
T
-------------------
D
V
R
R
A
L
D
K
D
I
Q
T
----
A
S
Q
V
K
--
G
----------------------
L
D
I
L
I
T
G
----
H
A
H
V
-------------
G
T
--
P
E
P
I
-----------------
K
V
G
N
-------------------
T
L
I
L
S
T
DSG
G
I
D
V
G
K
--
L
V
L
------
D
Y
K
---
E
-
K
P
H
N
F
T
V
K
N
-
F
E
L
K
T
I
Y
A
D
--
E
W
K
P
--------
D
Q
Q
T
-----
K
Q
V
I
D
G
W
N
K
K
L
---------
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
--
L
K
R
A
Y
G
E
S
---------
A
S
L
G
N
L
A
A
D
-----
A
L
L
A
A
A
-----
G
K
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
---
P
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
-
R
S
L
M
---
E
H
G
A
S
---
L
-----
S
N
G
---------
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
G
Q
R
------
V
I
T
L
T
L
---
N
G
K
P
I
E
D
---
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
--
A
R
--
N
I
T
G
---
G
---
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
-----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.75
23%
-36
- C1 -
4H2I
5
5NTD_HUMAN
A:
[4-491]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
---
S
K
C
V
D
A
S
R
--
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
E
P
N
--
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
--------------
E
G
L
I
E
P
L
L
K
E
-----
A
K
F
P
I
L
S
A
N
I
K
A
K
GP
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
--
L
P
V
G
D
E
V
V
--
G
I
V
G
Y
----
T
S
K
E
T
P
--
F
-
L
S
N
P
G
T
N
L
V
F
---
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
-------------------
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
G
N
PP
S
----------------------
K
E
V
P
A
G
K
----
Y
P
F
I
-------------
V
T
--
S
D
-------------------
D
G
R
K
-------------------
V
P
V
V
Q
----
A
Y
A
F
G
K
--
Y
L
G
------
Y
L
K
---
I
-
E
F
D
-
E
R
G
N
V
-
I
S
S
H
G
N
P
I
L
LD
S
S
I
P
--------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
---------
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
----
M
----
G
N
L
I
C
D
A
M
I
-----
N
N
N
L
R
H
ADEMF
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
---
S
-----
T
G
E
---------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
-
V
L
C
T
K
C
---
R
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
--
L
R
--
H
D
S
G
---
D
---
Q
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
---------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.72
23%
-40
- C1 -
4H2G
5
5NTD_HUMAN
A:
[23-513]
----------------------------------------------------
P
----
W
E
-------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
---
S
K
C
V
D
A
S
R
--
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
E
P
N
--
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
--------------
E
G
L
I
E
P
L
L
K
E
-----
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
--
L
P
V
G
D
E
V
V
--
G
I
V
G
Y
----
T
S
K
E
T
P
--
F
-
L
S
N
P
G
T
N
L
V
F
---
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
-------------------
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
G
N
PP
S
----------------------
K
E
V
P
A
G
K
----
Y
P
F
I
-------------
V
T
--
S
D
-------------------
D
G
R
K
-------------------
V
P
V
V
Q
----
A
Y
A
F
G
K
--
Y
L
G
------
Y
L
K
---
I
-
E
F
D
-
E
R
G
N
V
-
I
S
S
H
G
N
P
I
L
LD
S
S
I
P
--------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
---------
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
----
M
----
G
N
L
I
C
D
A
M
I
-----
N
N
N
L
R
H
ADEMF
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
---
S
-----
T
G
E
---------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
-
V
L
C
T
A
C
---
A
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
--
L
R
--
H
D
S
G
---
D
---
Q
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.68
26%
-61
- C1 -
2Z1A
4
?
A:
[112-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
G
N
H
E
F
D
L
G
------------
P
G
P
L
A
D
F
--------
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
--
R
E
P
R
L
K
G
L
F
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
----
I
G
L
----
T
T
P
D
T
R
E
I
---
S
N
P
G
P
T
V
A
F
---
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
----------
L
G
Y
-------------------
G
E
D
L
K
L
A
R
R
L
V
------------
G
----------------------
V
Q
V
I
V
G
G
----
H
S
H
T
-------------
L
L
--
G
S
-------------------
F
P
H
K
ELSPAGPY
P
T
V
V
K
N
PEG
K
D
V
L
V
V
Q
----
A
W
E
W
G
K
--
V
V
G
L
L
E
V
T
F
D
A
K
---
G
E
L
L
A
Y
K
G
E
A
L
-
L
M
T
P
E
A
-------
A
P
--------
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
---------
Q
Q
V
----
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
R
R
E
S
N
L
----
G
N
L
I
T
D
G
M
L
-----
W
K
T
R
N
A
-----
G
T
Q
I
--
A
L
Q
N
G
G
G
I
R
A
S
I
---
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
N
---
T
-----
A
G
R
---------
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
A
G
S
R
V
V
R
V
E
-
V
K
T
E
K
G
---
Y
-
V
P
L
D
L
---
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
GY
R
V
--
D
T
G
F
---
S
---
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
-------------------------------------------------------------------------------------------------------------------------
51
Fugue
81.07
18%
-43
- C1 -
2WDC
18
?
A:
[21-562]
YDLPPYGDATLLYFSDLHGQA
F
P
H
Y
F
M
E
P
P
N
L
I
A
P
K
P
L
M
G
R
P
G
Y
L
T
G
E
A
I
L
R
Y
----
Y
G
VERGT
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
G
P
I
----------
G
G
--
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
V
E
A
E
G
G
K
--
A
L
V
L
D
G
G
D
T
W
T
N
S
-
G
L
S
L
L
T
R
G
-
E
A
V
V
R
W
Q
N
L
V
G
V
D
-
H
M
V
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
L
G
L
--------------------
F
R
G
E
F
L
S
Y
N
I
V
D
D
--
L
F
G
D
P
L
F
--
P
A
Y
R
I
H
R
V
----
G
P
Y
A
L
A
V
V
G
A
----
S
Y
P
Y
V
K
V
S
H
-
P
E
S
F
T
E
G
L
S
F
---
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
--
N
G
M
Q
L
D
A
A
L
A
E
-------------------------------------
R
I
R
--
G
----------------------
I
D
L
I
L
S
G
----
H
T
H
D
-------------
L
T
P
R
P
W
-------------------
R
V
G
K
-------------------
T
W
I
V
A
----
G
S
A
A
G
K
------------
A
L
---
M
-
R
V
D
L
K
L
W
K
G
G
I
A
N
L
R
V
R
V
L
--
P
V
L
A
--------
E
H
L
P
K
A
E
D
V
E
A
F
L
K
A
Q
L
A
P
H
---------
Q
D
H
L
F
T
P
L
A
V
S
E
--
T
L
L
Y
K
R
------
D
T
L
----
Y
S
T
W
D
Q
L
V
G
-----
E
A
V
K
A
I
-----
Y
P
E
V
E
V
V
F
S
P
--
A
V
R
W
G
T
T
I
L
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
---
D
I
A
S
N
---
V
-----
F
T
S
DPFYQQG
G
D
V
S
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
P
T
G
E
R
------
V
R
E
V
E
V
---
G
G
R
P
L
D
P
---
N
R
R
Y
L
A
A
A
Y
-----
G
G
R
L
Q
R
V
G
E
A
K
P
------------------------------------------------------------------------
G
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
R
P
E
P
N
V
K
V
I
G
------------
R
N
Y
R
L
P
-----------------------------
E
V
T
G
-----------