@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1411: (2015-12-07 )
MRLNYLPSEFQKALPILKKIKKAGYEAYFVGGSVRDVLLDRPIHDVDIATSSYPEETKQIFKRTVDVGIEHGTVLVLEKGGEYEITTFRTEEVYVDYRRPSQVNFVRSLEEDLKRRDFTVNAFALNEDGEVIDLFHGLDDLDNHLLRAVGLASERFNEDALRIMRGLRFSASLNFDIETTTFEAMKKHASLLEKISVERSFIEFDKLLLAPYWRKGMLALIDSHAFNYLPCLKNRELQLSAFLSQLDKDFLFETSEQAWASLILSMEVEHTKTFLKKWKTSTHFQKDVEHIVDVYRIREQMGLTKEHLYRYGKTIIKQAEGIRKARGLMVDFEKIEQLDSELAIHDRHEIVVNGGTLIKKLGIKPGPQMGDIISQIELAIVLGQLINEEEAILHFVKQYLMD
Atome Classification :
(20 SA)
-----.........10---.-----.......20..----......30........40..---......50........60...-----.----....70-------.--......-.----80........90........100.......110.......120...----.-.-.---------.130.......140.......150.......160.......170.---..---....180.......--190.........200.......210.......220.......-230.....--------.----------.240-.........-----------------------250---------------------........----------.260.-----......270----------------.........280.......290....-.-.-.--300---.....----....310--.....---...-.320...-.--..-.-330-........340.-------......-350.......360.......370.......380.......390.......400--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MRLNYL
P
S
E
F
Q
---
K
-----
A
L
P
I
L
K
K
I
K
KA----GY
E
A
Y
F
VGG
S
V
R
D
V
L
LDRPI---HDVDIATSSY
P
E
E
T
K
Q
I
F
K
R
T
-----
V
----
D
VGIEH-------
G
--
T
V
L
V
L
E-K----GG
E
Y
E
I
T
T
F
R
T
E
E
V
Y
V
D
YRRP
S
Q
V
N
F
V
R
S
L
E
E
D
L
K
RRD
F
T
V
N
A
F
A
L----N-E-D---------G
E
V
I
D
L
F
H
G
L
D
D
L
D
N
H
L
L
R
A
VG
L
A
S
ERF
N
E
D
A
L
R
I
M
R
GLRF
S
A
S
L
---
N
F
---
D
I
ET
T
T
F
E
A
M
K
K
H
A
--
S
--
L
L
E
K
I
S
V
E
R
S
F
I
E
F
D
K
L
L
L
A
P
Y
W
RK
G
M
L
A
L
I
D
SHAFNYL-PCLKNRE
L
--------
Q
----------
L
S
---
A
F
L
S
QL
D
K
D
-----------------------
F
-----------------------LFE
T
S
E
Q
A
----------
W
A
S
L
I
-----
L
S
M
E
V
E
H
------------------
T
K
T
F
L
K
KWKTST
H
F
Q
K
D
V
E
H
I
V
D
V
Y
R
-
I
-
R
-
E
--
Q
-----MGL
T
K
----
E
H
L
Y
R
----
Y
G
K
T
I
---
I
K
Q
-
A
E
G
I
R
K
A
-R--G
L
-
M
-V
D
--
F
E
K
I
E
Q
L
D
S
E
LA-------IHDR
H
E
-
I
V
VN
G
G
T
L
I
K
KLGIKPGP
Q
M
G
D
I
I
S
Q
I
E
L
A
I
V
L
G
Q
L
IN
E
E
E
A
I
L
H
F
V
K
Q
Y
LMD--
30
HHSearch
98.80
40%
-81
- C4 -
1MIW
2
CCA_GEOSE
A:
[1-397]
----------
M
K
P
P
F
Q
---
E
-----
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
-----
I
----
D
V
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
---
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
--------
Q
----------
L
----
R
L
A
A
A
-
Y
R
W
-----------------------
P
-----------------------
W
L
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
E
------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
-
D
-
I
P
R
--
P
-----
E
A
W
T
N
----
E
Q
L
F
S
----
A
G
L
E
R
---
A
L
S
-
V
E
T
V
R
A
A
-
F
T
G
A
P
-
P
G
P
W
--
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
T
--
2
PsiBlast_PDB
97.92
40%
-84
- C4 -
1MIV
1
CCA_GEOSE
A:
[5-395]
--------------
F
Q
---
E
-----
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
-----
I
----
D
V
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
---
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
--------
Q
----------
L
R
-----
L
A
A
A
Y
R
W
-----------------------
P
-----------------------
W
L
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
E
------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
-
P
-
R
--
P
-----
E
A
W
T
N
----
E
Q
L
F
S
----
A
G
L
E
R
---
A
L
S
-
V
E
T
V
R
A
A
F
T
--
G
A
-
P
-
P
G
P
W
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
T
--
3
PsiBlast_PDB
97.07
40%
-82
- C4 -
1MIW
2
CCA_GEOSE
A:
[5-395]
--------------
F
Q
---
E
-----
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
-----
I
----
D
V
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
---
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
--------
Q
----------
L
R
-----
L
A
A
A
Y
R
W
-----------------------
P
-----------------------
W
L
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
E
------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
-
P
-
R
--
P
-----
E
A
W
T
N
----
E
Q
L
F
S
----
A
G
L
E
R
---
A
L
S
-
V
E
T
V
R
A
A
F
T
--
G
A
-
P
-
P
G
P
W
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
T
--
1
PsiBlast_PDB
96.94
41%
-85
- C4 -
1MIY
3
CCA_GEOSE
A:
[5-393]
--------------
F
Q
---
E
-----
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
-----
I
----
D
V
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
---
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
--------
Q
----------
L
R
-----
L
A
A
A
Y
R
W
-----------------------
P
-----------------------
W
L
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
E
------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
-
P
-
R
--
P
-----
E
A
W
T
N
----
E
Q
L
F
S
----
A
G
L
E
R
---
A
L
S
-
V
E
T
V
R
A
A
F
T
--
G
A
-
P
-
P
G
P
W
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
T
--
21
PsiBlast_CBE
95.94
41%
-84
- C4 -
1MIY
3
CCA_GEOSE
B:
[5-393]
--------------
F
Q
---
E
-----
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
-----
I
----
D
V
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
---
G
F
---
A
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
--------
Q
----------
L
R
-----
L
A
A
A
Y
R
W
-----------------------
P
-----------------------
W
L
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
E
------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
-
P
-
R
--
P
-----
E
A
W
T
N
----
E
Q
L
F
S
----
A
G
L
E
R
---
A
L
S
-
V
E
T
V
R
A
A
F
T
--
G
A
-
P
-
P
G
PW
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
T
--
57
Fugue
74.42
23%
-58
- C4 -
3AQL
2
?
A:
[1-411]
QVTVI
P
R
E
Q
H
A
I
S
R
K
D
ISE
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
-------------
G
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
------
P
--------
T
----------
I
T
---
R
Y
F
T
E
N
G
D
S
-----------------------
P
-----------------------
M
E
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
------------------
R
V
N
--
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
-
Q
-
E
-
S
--
G
-----
L
T
Y
H
D
----
A
F
A
L
A
----
M
N
D
V
L
---
D
E
A
-
C
R
S
L
A
I
P
-
K
--
R
L
-
T
-
T
L
--
T
R
D
I
W
Q
L
Q
L
R
M
S
-------
R
R
Q
G
K
-----
R
A
W
K
L
L
E
H
P
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
33
HHSearch
71.56
27%
-76
- C4 -
3AQL
2
?
A:
[15-352]
-----------
K
D
I
S
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
T
--------
E
NGDS
P
M
E
R
I
I
E
Q
---
V
L
K
N
T
-
D
T
R
I
H
N
--------------------
D
-----------------------
M
R
V
N
P
A
F
L
----------
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
GLT
Y
H
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
K
R
L
T
T
L
T
R
D
I
W
Q
L
Q
L
-
R
-
M
-
S
--
R
-----
R
Q
G
K
R
----
A
W
K
L
L
----
E
H
P
K
F
---
R
A
A
-
Y
D
L
L
A
L
R
-
A
--
E
V
-
E
-
R
N
--
A
E
L
Q
R
L
V
K
W
W
G
E
-------
F
Q
V
S
A
P
-
P
D
Q
K
G
M
L
------------------------------------------------
31
HHSearch
69.36
23%
-50
- C4 -
3H38
-
?
A:
[13-424]
-----------
E
R
V
D
P
---
K
-----
I
L
N
L
F
R
L
L
G
K
F
G
D
E
V
N
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
N
---
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
Y
A
K
R
F
-----
L
P
G
K
L
V
K
H
D
K
F
-------
M
--
T
A
S
L
F
L
K
G
----
G
L
R
I
D
I
A
T
A
R
L
E
Y
Y
E
S
P
A
K
L
P
D
-
V
E
-
M
S
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
----
K
-
L
-
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
V
L
H
T
--
L
S
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
---
D
F
---
R
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
--
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
F
P
K
T
Y
Y
T
P
S
--------
M
----------
D
E
K
M
E
N
L
F
R
N
I
P
W
V
-----------------------
E
-----------------------
E
N
F
G
E
V
D
R
----------
F
Y
A
V
L
-----
H
V
F
L
E
F
Y
D
D
E
S
--------------
W
K
E
V
R
D
R
Y
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
-
A
-
L
L
E
M
L
S
-----
E
R
V
P
A
----
S
F
V
Y
P
LVKG
V
S
N
E
T
---
I
C
H
-
F
L
A
Y
L
---
S
--
G
----
E
K
--
E
G
L
F
K
S
Y
L
L
K
----------
I
K
N
T
K
L
E
K
I
N
G
E
Y
L
I
R
K
-
G
I
T
S
G
K
I
I
G
E
V
L
E
K
I
L
M
K
K
L
D
G
D
T
R
D
E
E
E
I
-
L
E
E
V
L
A
S
L
----
32
HHSearch
68.57
23%
-63
* C4 *
3WFO
4
?
A:
[24-448]
-------------------------
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
-----
I
G
G
H
F
F
V
F
E
----------P
T
I
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
G
K
-------
D
-----
L
E
K
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
----
N
-
L
-
D
D
V
L
SIGA
K
Q
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
--
S
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
---
N
L
---
Q
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
--
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
I
P
E
I
G
R
L
R
E
VKDP
L
D
E
H
T
----------
L
K
---
T
L
E
Y
L
-
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLG
E
-----------------------
F
T
D
V
E
L
L
K
----------
W
G
A
L
F
-----
H
D
I
G
K
P
Q
TFVTFYE
H
D
K
V
G
A
Q
I
---
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
L
-
R
P
F
-
F
L
-
R
E
A
F
K
K
G
E
L
K
R
R
G
M
A
N
F
W
R
E
----
C
G
D
I
A
P
H
L
F
L
L
S
I
A
D
A
M
A
S
-
G
--
D
E
-
E
-
E
D
--
I
K
A
L
M
E
T
I
A
E
L
E
S
F
N
R
NEM
K
-------------------------------------------------------------
55
Fugue
66.81
25%
-53
- C4 -
1VFG
1
?
A:
[1-351]
---------------------------
M
V
G
Q
I
A
K
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
H
G
V
N
-
V
----
H
P
F
P
E
F
-------
G
--
T
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
V
E
P
A
-----------
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VNL
E
-
D
-
Y
---------
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
--
P
V
S
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
---
N
F
---
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
-
I
E
G
F
Q
W
N
E
--------
K
----------
V
L
---
Q
K
L
Y
A
L
R
K
V
-----------------------
V
-----------------------
D
W
H
A
L
E
F
S
EERIDY
G
W
L
Y
L
L
I
L
I
-----
S
N
L
D
Y
E
R
------------------
G
K
H
F
L
E
E
M
S
A
P
S
W
V
R
E
T
Y
K
F
M
K
F
K
L
G
-
S
-
L
-
K
--
E
-----
E
L
K
K
A
----
K
E
N
Y
E
----
V
Y
R
L
L
---
K
P
L
-
H
T
S
V
L
L
L
-
L
--
M
L
-
E
-
E
E
--
L
K
E
K
I
K
L
Y
L
E
K
L
-------
R
K
V
K
L
P
--------------------------------------------------------
56
Fugue
66.78
26%
-59
- C4 -
1OU5
-
TRNT1_HUMAN
A:
[-1-354]
------
K
M
K
L
Q
S
P
E
F
Q
---
S
LFTEG
L
K
S
L
T
E
L
F
V
K
E
----
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
G
I
R
M
I
N
----
N
R
G
E
K
H
-------
G
--
T
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
I
--------------
F
T
T
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
----
G
-
F
-
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
---
V
D
KPG
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
--
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
-
G
L
P
A
N
A
S
L
------------------------
E
E
F
D
K
V
S
K
N
-----------------------
V
-----------------------
D
G
F
S
P
K
P
V
----------
T
L
L
A
S
-----
L
F
K
V
Q
D
D
------------------
V
T
K
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
-
D
-
L
-
I
--
K
-----
A
T
D
S
S
----
D
P
L
K
P
----
Y
Q
D
F
I
---
I
D
S
-
R
E
P
D
A
T
T
-
R
--
V
C
E
L
-
L
K
--
Y
Q
G
E
H
C
L
L
K
E
M
Q
-------
Q
W
S
I
----------------------------------------------------------
4
PsiBlast_PDB
66.12
35%
-88
- C4 -
3AQM
1
?
A:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
7
PsiBlast_PDB
65.72
34%
-91
- C4 -
3AQN
2
?
A:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
6
PsiBlast_PDB
65.27
34%
-88
- C4 -
3AQL
2
?
A:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
24
PsiBlast_CBE
64.97
34%
-85
- C4 -
3AQL
2
?
B:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
23
PsiBlast_CBE
64.55
34%
-87
- C4 -
3AQN
1
?
B:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
22
PsiBlast_CBE
64.54
35%
-81
- C4 -
3AQM
1
?
B:
[19-248]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
------------
5
PsiBlast_PDB
64.19
34%
-82
- C4 -
3AQK
-
?
A:
[35-264]
---------------
E
---
N
-----
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
-----
R
----
L
V
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
--------------
N
I
F
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
---
G
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
--------
T
----------
E
N
---
G
D
S
P
M
E
R
I
I
-----------------------
E
-----------------------
Q
V
L
K
N
T
D
T
----------
R
I
H
N
D
-----
M
R
V
N
P
A
F
------------------
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
-
D
-
A
-
F
--
A
-----
L
A
M
N
D
----
V
L
D
E
A
----
C
R
S
L
A
---
I
P
K
-
R
L
T
T
L
T
R
-
D
--
I
W
-
Q
-
L
Q
--
L
R
M
S
R
R
Q
G
K
R
A
W
-------
K
L
L
E
H
P
-
K
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
N
E
L
D
--------
34
HHSearch
61.98
24%
-72
- C4 -
3WFP
1
?
A:
[6-290]
--------------
L
S
---
Y
-----
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
-----
I
GG
H
F
F
V
F
E
K
R
G
FLIK
R
P
T
--
I
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
G
K
------------
D
L
E
K
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
----
N
-
L
-
D
D
V
L
SIGAKQ
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
--
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
---
N
L
---
Q
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
--
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
I
P
E
I
G
R
L
R
E
VKDP
L
D
E
H
T
----------
L
K
---
T
L
E
Y
L
-
E
Q
V
-----------------------
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGE
F
T
D
V
E
L
L
K
----------
W
G
A
L
F
-----
H
D
I
G
K
P
Q
TFVTFYE
H
D
K
V
G
A
Q
I
---
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
L
-
R
-
P
-
F
--
F
-----
L
R
E
A
F
----
K
K
G
E
L
----
K
R
R
G
M
---
A
N
F
-
W
R
E
C
G
D
I
-
A
--
P
H
-
L
-
F
L
--
L
S
I
A
D
A
M
A
S
G
D
E
-------
E
E
D
I
K
A
-
L
M
E
T
I
A
E
L
E
S
F
N
R
N
E
M
K
E
E
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
--
25
PsiBlast_CBE
59.64
35%
-72
- C4 -
4X4W
9
TRNT1_HUMAN
B:
[28-222]
----------------------------------
K
E
----
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
G
I
R
M
I
N
-----------------
G
--
T
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
I
D
-
V
T
T
D
----
A
E
V
E
F
T
T
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
----
G
-
F
-
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
VDK
P
G
---
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
--
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
-
G
L
P
A
N
A
S
L
--------
E
----------
E
F
---
D
K
V
S
K
N
V
D
G
-----------------------
F
-----------------------
S
P
K
P
V
T
L
L
----------
A
S
L
F
K
-----
V
Q
D
D
V
T
K
------------------
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
D
L
I
-
K
-
A
-
T
--
D
-----
S
S
D
P
L
----
K
P
Y
Q
D
----
F
I
I
D
S
---
D
A
T
-
T
R
V
C
E
L
L
-
K
--
Y
Q
-
G
-
E
H
--
C
L
L
K
E
M
Q
Q
W
S
I
P
-------
P
F
P
V
S
G
-
H
D
I
R
K
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
----------